Harvard Catalyst Profiles

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David James Thornton, M.D., M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fillmore NR, Elbers DC, La J, Feldman TC, Sung FC, Hall RB, Nguyen V, Link N, Zwolinski R, Dipietro S, Miller SJ, Aleksanyan A, Goryachev SD, Corcoran P, Bergstrom SJ, Parenteau MA, Sprague RS, Thornton DJ, Driver JA, Strymish JM, Evans S, Colonna B, Brophy MT, Do NV. Corrigendum to: An Application to Support COVID-19 Occupational Health and Patient Tracking at a Veterans Affairs Medical Center. J Am Med Inform Assoc. 2021 03 01; 28(3):673. PMID: 33306790; PMCID: PMC7799026.
    Citations:    Fields:    
  2. Fillmore NR, Elbers DC, La J, Feldman TC, Sung FC, Hall RB, Nguyen V, Link N, Zwolinski R, Dipietro S, Miller SJ, Aleksanyan A, Goryachev SD, Corcoran P, Bergstrom SJ, Parenteau MA, Sprague RS, Thornton DJ, Driver JA, Strymish JM, Evans S, Colonna B, Brophy MT, Do NV. An application to support COVID-19 occupational health and patient tracking at a Veterans Affairs medical center. J Am Med Inform Assoc. 2020 11 01; 27(11):1716-1720. PMID: 33067628.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  3. Yakovchenko V, DeSotto K, Drainoni ML, Lukesh W, Miller DR, Park A, Shao Q, Thornton DJ, Gifford AL. Using Lean-Facilitation to Improve Quality of Hepatitis C Testing in Primary Care. J Gen Intern Med. 2021 02; 36(2):349-357. PMID: 32930938; PMCID: PMC7878607.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  4. Hakim A, Braun H, Thornton D, Strymish J. Successful treatment of methicillin-sensitive Staphylococcus aureus tricuspid-valve endocarditis with dalbavancin as an outpatient in a person who injects drugs: A case report. Int J Infect Dis. 2020 Feb; 91:202-205. PMID: 31841726.
    Citations: 6     Fields:    Translation:HumansCells
  5. Jenson D, Reilly KJ, Harkrider AW, Thornton D, Saltuklaroglu T. Trait related sensorimotor deficits in people who stutter: An EEG investigation of µ rhythm dynamics during spontaneous fluency. Neuroimage Clin. 2018; 19:690-702. PMID: 29872634.
    Citations: 3     Fields:    Translation:Humans
  6. Melo-Gonzalez F, Fenton TM, Forss C, Smedley C, Goenka A, MacDonald AS, Thornton DJ, Travis MA. Intestinal mucin activates human dendritic cells and IL-8 production in a glycan-specific manner. J Biol Chem. 2018 06 01; 293(22):8543-8553. PMID: 29581231; PMCID: PMC5986209.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  7. Shears RK, Bancroft AJ, Sharpe C, Grencis RK, Thornton DJ. Vaccination Against Whipworm: Identification of Potential Immunogenic Proteins in Trichuris muris Excretory/Secretory Material. Sci Rep. 2018 03 14; 8(1):4508. PMID: 29540816.
    Citations: 10     Fields:    Translation:AnimalsPHPublic Health
  8. Sharpe C, Thornton DJ, Grencis RK. A sticky end for gastrointestinal helminths; the role of the mucus barrier. Parasite Immunol. 2018 04; 40(4):e12517. PMID: 29355990.
    Citations: 23     Fields:    Translation:AnimalsCells
  9. Anderson MC, Chaze T, Coïc YM, Injarabian L, Jonsson F, Lombion N, Selimoglu-Buet D, Souphron J, Ridley C, Vonaesch P, Baron B, Arena ET, Tinevez JY, Nigro G, Nothelfer K, Solary E, Lapierre V, Lazure T, Matondo M, Thornton D, Sansonetti PJ, Baleux F, Marteyn BS. MUB40 Binds to Lactoferrin and Stands as a Specific Neutrophil Marker. Cell Chem Biol. 2018 04 19; 25(4):483-493.e9. PMID: 29478905.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Trillo-Muyo S, Nilsson HE, Recktenwald CV, Ermund A, Ridley C, Meiss LN, Bähr A, Klymiuk N, Wine JJ, Koeck PJB, Thornton DJ, Hebert H, Hansson GC. Granule-stored MUC5B mucins are packed by the non-covalent formation of N-terminal head-to-head tetramers. J Biol Chem. 2018 04 13; 293(15):5746-5754. PMID: 29440393.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  11. Carvalho SB, Moreira AS, Gomes J, Carrondo MJT, Thornton DJ, Alves PM, Costa J, Peixoto C. A detection and quantification label-free tool to speed up downstream processing of model mucins. PLoS One. 2018; 13(1):e0190974. PMID: 29315346.
    Citations: 4     Fields:    Translation:Cells
  12. Dubaissi E, Rousseau K, Hughes GW, Ridley C, Grencis RK, Roberts IS, Thornton DJ. Functional characterization of the mucus barrier on the Xenopus tropicalis skin surface. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):726-731. PMID: 29311327; PMCID: PMC5789918.
    Citations: 6     Fields:    Translation:AnimalsCells
  13. Ermund A, Meiss LN, Rodriguez-Pineiro AM, Bähr A, Nilsson HE, Trillo-Muyo S, Ridley C, Thornton DJ, Wine JJ, Hebert H, Klymiuk N, Hansson GC. The normal trachea is cleaned by MUC5B mucin bundles from the submucosal glands coated with the MUC5AC mucin. Biochem Biophys Res Commun. 2017 10 21; 492(3):331-337. PMID: 28859985; PMCID: PMC5596833.
    Citations: 48     Fields:    Translation:Animals
  14. Welsh KG, Rousseau K, Fisher G, Bonser LR, Bradding P, Brightling CE, Thornton DJ, Gaillard EA. MUC5AC and a Glycosylated Variant of MUC5B Alter Mucin Composition in Children With Acute Asthma. Chest. 2017 10; 152(4):771-779. PMID: 28716644; PMCID: PMC5624091.
    Citations: 28     Fields:    Translation:Humans
  15. Thornton D, Harkrider AW, Jenson D, Saltuklaroglu T. Sensorimotor activity measured via oscillations of EEG mu rhythms in speech and non-speech discrimination tasks with and without segmentation demands. Brain Lang. 2018 12; 187:62-73. PMID: 28431691.
    Citations: 5     Fields:    Translation:Humans
  16. Hasnain SZ, Dawson PA, Lourie R, Hutson P, Tong H, Grencis RK, McGuckin MA, Thornton DJ. Immune-driven alterations in mucin sulphation is an important mediator of Trichuris muris helminth expulsion. PLoS Pathog. 2017 02; 13(2):e1006218. PMID: 28192541; PMCID: PMC5325613.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  17. Stukus DR, Kempe E, Leber A, Thornton D, Scherzer R. Use of Food Allergy Panels by Pediatric Care Providers Compared With Allergists. Pediatrics. 2016 12; 138(6). PMID: 27940693.
    Citations: 1     Fields:    Translation:Humans
  18. Cowley AC, Thornton DJ, Denning DW, Horsley A. Aspergillosis and the role of mucins in cystic fibrosis. Pediatr Pulmonol. 2017 04; 52(4):548-555. PMID: 27870227; PMCID: PMC5396363.
    Citations: 14     Fields:    Translation:HumansAnimals
  19. Davies HS, Singh P, Deckert-Gaudig T, Deckert V, Rousseau K, Ridley CE, Dowd SE, Doig AJ, Pudney PD, Thornton DJ, Blanch EW. Secondary Structure and Glycosylation of Mucus Glycoproteins by Raman Spectroscopies. Anal Chem. 2016 12 06; 88(23):11609-11615. PMID: 27791356.
    Citations: 14     Fields:    Translation:HumansCells
  20. Dickey BF, Fahy JV, Kesimer M, Boucher RC, Evans CM, Thornton D. Measuring Airway Mucin 2 in Patients with Severe Chronic Obstructive Pulmonary Disease with Bacterial Colonization. Ann Am Thorac Soc. 2016 11; 13(11):2103-2104. PMID: 27831803.
    Citations: 4     Fields:    Translation:Humans
  21. Ridley C, Kirkham S, Williamson SJ, Davis CW, Woodman P, Thornton DJ. Biosynthesis of the polymeric gel-forming mucin MUC5B. Am J Physiol Lung Cell Mol Physiol. 2016 05 15; 310(10):L993-L1002. PMID: 26993521; PMCID: PMC4896102.
    Citations: 10     Fields:    Translation:HumansCells
  22. Sorokin V, Alkhoury R, Al-Rawabdeh S, Houston RH, Thornton D, Kerlin B, O'Brien S, Baker P, Boesel C, Uddin M, Yin H, Kahwash S. Reference Range of Platelet Delta Granules in the Pediatric Age Group: An Ultrastructural Study of Platelet Whole Mount Preparations from Healthy Volunteers. Pediatr Dev Pathol. 2016 Nov/Dec; 19(6):498-501. PMID: 26670096.
    Citations: 5     Fields:    Translation:HumansCells
  23. Wang H, Kim JJ, Denou E, Gallagher A, Thornton DJ, Shajib MS, Xia L, Schertzer JD, Grencis RK, Philpott DJ, Khan WI. New Role of Nod Proteins in Regulation of Intestinal Goblet Cell Response in the Context of Innate Host Defense in an Enteric Parasite Infection. Infect Immun. 2016 01; 84(1):275-85. PMID: 26527214.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  24. Peffers MJ, Thornton DJ, Clegg PD. Characterization of neopeptides in equine articular cartilage degradation. J Orthop Res. 2016 Jan; 34(1):106-20. PMID: 26124002; PMCID: PMC4737130.
    Citations: 11     Fields:    Translation:HumansAnimals
  25. Georgiades P, di Cola E, Heenan RK, Pudney PD, Thornton DJ, Waigh TA. A combined small-angle X-ray and neutron scattering study of the structure of purified soluble gastrointestinal mucins. Biopolymers. 2014 Dec; 101(12):1154-64. PMID: 25041765.
    Citations: 8     Fields:    Translation:AnimalsCells
  26. Davies HS, Pudney PD, Georgiades P, Waigh TA, Hodson NW, Ridley CE, Blanch EW, Thornton DJ. Reorganisation of the salivary mucin network by dietary components: insights from green tea polyphenols. PLoS One. 2014; 9(9):e108372. PMID: 25264771.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  27. Georgiades P, Pudney PD, Rogers S, Thornton DJ, Waigh TA. Tea derived galloylated polyphenols cross-link purified gastrointestinal mucins. PLoS One. 2014; 9(8):e105302. PMID: 25162539.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Hansen AL, Dahl L, Olson G, Thornton D, Graff IE, Frøyland L, Thayer JF, Pallesen S. Fish consumption, sleep, daily functioning, and heart rate variability. J Clin Sleep Med. 2014 May 15; 10(5):567-75. PMID: 24812543.
    Citations: 32     Fields:    Translation:HumansAnimals
  29. Ridley C, Kouvatsos N, Raynal BD, Howard M, Collins RF, Desseyn JL, Jowitt TA, Baldock C, Davis CW, Hardingham TE, Thornton DJ. Assembly of the respiratory mucin MUC5B: a new model for a gel-forming mucin. J Biol Chem. 2014 Jun 06; 289(23):16409-20. PMID: 24778189; PMCID: PMC4047408.
    Citations: 48     Fields:    
  30. Georgiades P, Pudney PD, Thornton DJ, Waigh TA. Particle tracking microrheology of purified gastrointestinal mucins. Biopolymers. 2014 Apr; 101(4):366-77. PMID: 23955640.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  31. Ehre C, Ridley C, Thornton DJ. Cystic fibrosis: an inherited disease affecting mucin-producing organs. Int J Biochem Cell Biol. 2014 Jul; 52:136-45. PMID: 24685676.
    Citations: 33     Fields:    Translation:HumansAnimals
  32. Dubaissi E, Rousseau K, Lea R, Soto X, Nardeosingh S, Schweickert A, Amaya E, Thornton DJ, Papalopulu N. A secretory cell type develops alongside multiciliated cells, ionocytes and goblet cells, and provides a protective, anti-infective function in the frog embryonic mucociliary epidermis. Development. 2014 Apr; 141(7):1514-25. PMID: 24598166.
    Citations: 27     Fields:    Translation:AnimalsCells
  33. Horsley A, Rousseau K, Ridley C, Flight W, Jones A, Waigh TA, Thornton DJ. Reassessment of the importance of mucins in determining sputum properties in cystic fibrosis. J Cyst Fibros. 2014 May; 13(3):260-6. PMID: 24332705; PMCID: PMC3994278.
    Citations: 10     Fields:    Translation:HumansCells
  34. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696.
    Citations: 296     Fields:    Translation:AnimalsCells
  35. Thornton D, Stappers B, Bailes M, Barsdell B, Bates S, Bhat ND, Burgay M, Burke-Spolaor S, Champion DJ, Coster P, D'Amico N, Jameson A, Johnston S, Keith M, Kramer M, Levin L, Milia S, Ng C, Possenti A, van Straten W. A population of fast radio bursts at cosmological distances. Science. 2013 Jul 05; 341(6141):53-6. PMID: 23828936.
    Citations: 15     Fields:    
  36. Bell PA, Wagener R, Zaucke F, Koch M, Selley J, Warwood S, Knight D, Boot-Handford RP, Thornton DJ, Briggs MD. Analysis of the cartilage proteome from three different mouse models of genetic skeletal diseases reveals common and discrete disease signatures. Biol Open. 2013 Aug 15; 2(8):802-11. PMID: 23951406.
    Citations: 7     Fields:    
  37. Maischberger E, Cummins CA, Fitzpatrick E, Gallagher ME, Worrall S, Rousseau K, Thornton DJ, Meijer WG, Miranda-Casoluengo R, Duggan VE, Carrington SD, Irwin JA, Reid CJ. The expression of mucin genes and the presence of mucin gene products in the equine endometrium. Res Vet Sci. 2013 Aug; 95(1):169-75. PMID: 23583093.
    Citations:    Fields:    Translation:Animals
  38. Harrop CA, Gore RB, Evans CM, Thornton DJ, Herrick SE. TGF-ß2 decreases baseline and IL-13-stimulated mucin production by primary human bronchial epithelial cells. Exp Lung Res. 2013 Feb; 39(1):39-47. PMID: 23249391.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  39. Hasnain SZ, Gallagher AL, Grencis RK, Thornton DJ. A new role for mucins in immunity: insights from gastrointestinal nematode infection. Int J Biochem Cell Biol. 2013 Feb; 45(2):364-74. PMID: 23107603.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  40. Hasnain SZ, McGuckin MA, Grencis RK, Thornton DJ. Serine protease(s) secreted by the nematode Trichuris muris degrade the mucus barrier. PLoS Negl Trop Dis. 2012; 6(10):e1856. PMID: 23071854.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  41. Robinson CV, Elkins MR, Bialkowski KM, Thornton DJ, Kertesz MA. Desulfurization of mucin by Pseudomonas aeruginosa: influence of sulfate in the lungs of cystic fibrosis patients. J Med Microbiol. 2012 Dec; 61(Pt 12):1644-1653. PMID: 22918866.
    Citations: 15     Fields:    Translation:HumansCells
  42. Farnell E, Rousseau K, Thornton DJ, Bowyer P, Herrick SE. Expression and secretion of Aspergillus fumigatus proteases are regulated in response to different protein substrates. Fungal Biol. 2012 Sep; 116(9):1003-12. PMID: 22954343.
    Citations: 21     Fields:    Translation:HumansAnimals
  43. Bell PA, Piróg KA, Fresquet M, Thornton DJ, Boot-Handford RP, Briggs MD. Loss of matrilin 1 does not exacerbate the skeletal phenotype in a mouse model of multiple epiphyseal dysplasia caused by a Matn3 V194D mutation. Arthritis Rheum. 2012 May; 64(5):1529-39. PMID: 22083516; PMCID: PMC3374853.
    Citations: 6     Fields:    Translation:AnimalsCells
  44. Barbier D, Garcia-Verdugo I, Pothlichet J, Khazen R, Descamps D, Rousseau K, Thornton D, Si-Tahar M, Touqui L, Chignard M, Sallenave JM. Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway. Am J Respir Cell Mol Biol. 2012 Aug; 47(2):149-57. PMID: 22383584.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  45. Harrop CA, Thornton DJ, McGuckin MA. Detecting, visualising, and quantifying mucins. Methods Mol Biol. 2012; 842:49-66. PMID: 22259129.
    Citations: 10     Fields:    Translation:HumansCells
  46. Davies JR, Wickström C, Thornton DJ. Gel-forming and cell-associated mucins: preparation for structural and functional studies. Methods Mol Biol. 2012; 842:27-47. PMID: 22259128.
    Citations: 12     Fields:    Translation:HumansCells
  47. Linares LA, Thornton DJ, Strymish J, Baker E, Gupta K. Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria. Infect Control Hosp Epidemiol. 2011 Jul; 32(7):644-8. PMID: 21666393.
    Citations: 18     Fields:    Translation:Humans
  48. Rousseau K, Cardwell JM, Humphrey E, Newton R, Knight D, Clegg P, Thornton DJ. Muc5b is the major polymeric mucin in mucus from thoroughbred horses with and without airway mucus accumulation. PLoS One. 2011; 6(5):e19678. PMID: 21602926.
    Citations: 1     Fields:    Translation:AnimalsCells
  49. Hasnain SZ, Evans CM, Roy M, Gallagher AL, Kindrachuk KN, Barron L, Dickey BF, Wilson MS, Wynn TA, Grencis RK, Thornton DJ. Muc5ac: a critical component mediating the rejection of enteric nematodes. J Exp Med. 2011 May 09; 208(5):893-900. PMID: 21502330; PMCID: PMC3092342.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  50. Hasnain SZ, Thornton DJ, Grencis RK. Changes in the mucosal barrier during acute and chronic Trichuris muris infection. Parasite Immunol. 2011 Jan; 33(1):45-55. PMID: 21155842.
    Citations: 41     Fields:    Translation:AnimalsCells
  51. Nundlall S, Rajpar MH, Bell PA, Clowes C, Zeeff LA, Gardner B, Thornton DJ, Boot-Handford RP, Briggs MD. An unfolded protein response is the initial cellular response to the expression of mutant matrilin-3 in a mouse model of multiple epiphyseal dysplasia. Cell Stress Chaperones. 2010 Nov; 15(6):835-49. PMID: 20428984; PMCID: PMC3024081.
    Citations: 37     Fields:    Translation:AnimalsCells
  52. Hasnain SZ, Wang H, Ghia JE, Haq N, Deng Y, Velcich A, Grencis RK, Thornton DJ, Khan WI. Mucin gene deficiency in mice impairs host resistance to an enteric parasitic infection. Gastroenterology. 2010 May; 138(5):1763-71. PMID: 20138044; PMCID: PMC3466424.
    Citations: 86     Fields:    Translation:AnimalsCells
  53. Rajpar MH, McDermott B, Kung L, Eardley R, Knowles L, Heeran M, Thornton DJ, Wilson R, Bateman JF, Poulsom R, Arvan P, Kadler KE, Briggs MD, Boot-Handford RP. Targeted induction of endoplasmic reticulum stress induces cartilage pathology. PLoS Genet. 2009 Oct; 5(10):e1000691. PMID: 19834559.
    Citations: 68     Fields:    Translation:AnimalsCells
  54. Viollet L, Gailey S, Thornton DJ, Friedman NR, Flanigan KM, Mahan JD, Mendell JR. Utility of cystatin C to monitor renal function in Duchenne muscular dystrophy. Muscle Nerve. 2009 Sep; 40(3):438-42. PMID: 19623638.
    Citations: 25     Fields:    Translation:Humans
  55. Kesimer M, Kiliç N, Mehrotra R, Thornton DJ, Sheehan JK. Identification of salivary mucin MUC7 binding proteins from Streptococcus gordonii. BMC Microbiol. 2009 Aug 11; 9:163. PMID: 19671172.
    Citations: 23     Fields:    Translation:HumansCells
  56. Quinn RP, Mahoney SJ, Wilkinson BM, Thornton DJ, Stirling CJ. A novel role for Gtb1p in glucose trimming of N-linked glycans. Glycobiology. 2009 Dec; 19(12):1408-16. PMID: 19542522.
    Citations: 10     Fields:    Translation:AnimalsCells
  57. Innes AL, Carrington SD, Thornton DJ, Kirkham S, Rousseau K, Dougherty RH, Raymond WW, Caughey GH, Muller SJ, Fahy JV. Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute asthma. Am J Respir Crit Care Med. 2009 Aug 01; 180(3):203-10. PMID: 19423716; PMCID: PMC2724713.
    Citations: 37     Fields:    Translation:Humans
  58. Elwood RW, Doren DM, Thornton D. Diagnostic and risk profiles of men detained under Wisconsin's sexually violent person law. Int J Offender Ther Comp Criminol. 2010 Apr; 54(2):187-96. PMID: 19056858.
    Citations: 2     Fields:    Translation:Humans
  59. Kesimer M, Kirkham S, Pickles RJ, Henderson AG, Alexis NE, Demaria G, Knight D, Thornton DJ, Sheehan JK. Tracheobronchial air-liquid interface cell culture: a model for innate mucosal defense of the upper airways? Am J Physiol Lung Cell Mol Physiol. 2009 Jan; 296(1):L92-L100. PMID: 18931053; PMCID: PMC2636953.
    Citations: 90     Fields:    Translation:HumansCells
  60. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ. MUC5B is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008 Nov 15; 178(10):1033-9. PMID: 18776153; PMCID: PMC2643221.
    Citations: 64     Fields:    Translation:Humans
  61. Rousseau K, Kirkham S, Johnson L, Fitzpatrick B, Howard M, Adams EJ, Rogers DF, Knight D, Clegg P, Thornton DJ. Proteomic analysis of polymeric salivary mucins: no evidence for MUC19 in human saliva. Biochem J. 2008 Aug 01; 413(3):545-52. PMID: 18426393.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  62. Fine HA, Puduvalli VK, Chamberlain MC, Carpentier AF, Cher L, Mason WP, van den Bent MJ, Hong S, Thornton D, Wick W. Enzastaurin (ENZ) versus lomustine (CCNU) in the treatment of recurrent, intracranial glioblastoma multiforme (GBM): A phase III study. J Clin Oncol. 2008 May 20; 26(15_suppl):2005. PMID: 27948440.
  63. Heazlewood CK, Cook MC, Eri R, Price GR, Tauro SB, Taupin D, Thornton DJ, Png CW, Crockford TL, Cornall RJ, Adams R, Kato M, Nelms KA, Hong NA, Florin TH, Goodnow CC, McGuckin MA. Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitis. PLoS Med. 2008 Mar 04; 5(3):e54. PMID: 18318598.
    Citations: 316     Fields:    Translation:HumansAnimalsCells
  64. Thornton DJ, Rousseau K, McGuckin MA. Structure and function of the polymeric mucins in airways mucus. Annu Rev Physiol. 2008; 70:459-86. PMID: 17850213.
    Citations: 312     Fields:    Translation:HumansAnimalsCells
  65. Fresquet M, Jowitt TA, Ylöstalo J, Coffey P, Meadows RS, Ala-Kokko L, Thornton DJ, Briggs MD. Structural and functional characterization of recombinant matrilin-3 A-domain and implications for human genetic bone diseases. J Biol Chem. 2007 Nov 30; 282(48):34634-43. PMID: 17881354.
    Citations: 20     Fields:    Translation:HumansCells
  66. Piróg-Garcia KA, Meadows RS, Knowles L, Heinegård D, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Reduced cell proliferation and increased apoptosis are significant pathological mechanisms in a murine model of mild pseudoachondroplasia resulting from a mutation in the C-terminal domain of COMP. Hum Mol Genet. 2007 Sep 01; 16(17):2072-88. PMID: 17588960; PMCID: PMC2674228.
    Citations: 50     Fields:    Translation:AnimalsCells
  67. Davies JR, Kirkham S, Svitacheva N, Thornton DJ, Carlstedt I. MUC16 is produced in tracheal surface epithelium and submucosal glands and is present in secretions from normal human airway and cultured bronchial epithelial cells. Int J Biochem Cell Biol. 2007; 39(10):1943-54. PMID: 17604678.
    Citations: 42     Fields:    Translation:HumansCells
  68. Leighton MP, Nundlall S, Starborg T, Meadows RS, Suleman F, Knowles L, Wagener R, Thornton DJ, Kadler KE, Boot-Handford RP, Briggs MD. Decreased chondrocyte proliferation and dysregulated apoptosis in the cartilage growth plate are key features of a murine model of epiphyseal dysplasia caused by a matn3 mutation. Hum Mol Genet. 2007 Jul 15; 16(14):1728-41. PMID: 17517694; PMCID: PMC2674230.
    Citations: 40     Fields:    Translation:AnimalsCells
  69. Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ. The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module. Matrix Biol. 2007 Jul; 26(6):485-93. PMID: 17490871; PMCID: PMC3345337.
    Citations: 2     Fields:    Translation:HumansCells
  70. Plumb DA, Dhir V, Mironov A, Ferrara L, Poulsom R, Kadler KE, Thornton DJ, Briggs MD, Boot-Handford RP. Collagen XXVII is developmentally regulated and forms thin fibrillar structures distinct from those of classical vertebrate fibrillar collagens. J Biol Chem. 2007 Apr 27; 282(17):12791-5. PMID: 17331945; PMCID: PMC2688011.
    Citations: 29     Fields:    
  71. Rousseau K, Kirkham S, McKane S, Newton R, Clegg P, Thornton DJ. Muc5b and Muc5ac are the major oligomeric mucins in equine airway mucus. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1396-404. PMID: 17293373.
    Citations: 14     Fields:    Translation:AnimalsCells
  72. Belluoccio D, Wilson R, Thornton DJ, Wallis TP, Gorman JJ, Bateman JF. Proteomic analysis of mouse growth plate cartilage. Proteomics. 2006 Dec; 6(24):6549-53. PMID: 17163436.
    Citations: 16     Fields:    Translation:Animals
  73. Solages A, Vita JA, Thornton DJ, Murray J, Heeren T, Craven DE, Horsburgh CR. Endothelial function in HIV-infected persons. Clin Infect Dis. 2006 May 01; 42(9):1325-32. PMID: 16586393; PMCID: PMC2737346.
    Citations: 90     Fields:    Translation:Humans
  74. Ballance S, Howard M, White KN, McCrohan CR, Thornton DJ, Sheehan JK. Partial characterisation of high-molecular weight glycoconjugates in the trail mucus of the freshwater pond snail Lymnaea stagnalis. Comp Biochem Physiol B Biochem Mol Biol. 2004 Apr; 137(4):475-86. PMID: 15081999.
    Citations: 2     Fields:    Translation:Animals
  75. Sheehan JK, Kirkham S, Howard M, Woodman P, Kutay S, Brazeau C, Buckley J, Thornton DJ. Identification of molecular intermediates in the assembly pathway of the MUC5AC mucin. J Biol Chem. 2004 Apr 09; 279(15):15698-705. PMID: 14749330.
    Citations: 46     Fields:    Translation:HumansCells
  76. Fleming CA, Christiansen D, Nunes D, Heeren T, Thornton D, Horsburgh CR, Koziel MJ, Graham C, Craven DE. Health-related quality of life of patients with HIV disease: impact of hepatitis C coinfection. Clin Infect Dis. 2004 Feb 15; 38(4):572-8. PMID: 14765352.
    Citations: 25     Fields:    Translation:Humans
  77. Middleton AM, Chadwick MV, Nicholson AG, Wilson R, Thornton DJ, Kirkham S, Sheehan JK. Interaction between mycobacteria and mucus on a human respiratory tissue organ culture model with an air interface. Exp Lung Res. 2004 Jan-Feb; 30(1):17-29. PMID: 14967601.
    Citations: 5     Fields:    Translation:HumansCells
  78. Thornton DJ, Sheehan JK. From mucins to mucus: toward a more coherent understanding of this essential barrier. Proc Am Thorac Soc. 2004; 1(1):54-61. PMID: 16113413.
    Citations: 95     Fields:    Translation:HumansAnimals
  79. Gray T, Coakley R, Hirsh A, Thornton D, Kirkham S, Koo JS, Burch L, Boucher R, Nettesheim P. Regulation of MUC5AC mucin secretion and airway surface liquid metabolism by IL-1beta in human bronchial epithelia. Am J Physiol Lung Cell Mol Physiol. 2004 Feb; 286(2):L320-30. PMID: 14527933.
    Citations: 44     Fields:    Translation:HumansCells
  80. Allen S, Lu H, Thornton D, Tokatlidis K. Juxtaposition of the two distal CX3C motifs via intrachain disulfide bonding is essential for the folding of Tim10. J Biol Chem. 2003 Oct 03; 278(40):38505-13. PMID: 12882976.
    Citations: 17     Fields:    Translation:Cells
  81. Raynal BD, Hardingham TE, Sheehan JK, Thornton DJ. Calcium-dependent protein interactions in MUC5B provide reversible cross-links in salivary mucus. J Biol Chem. 2003 Aug 01; 278(31):28703-10. PMID: 12756239.
    Citations: 48     Fields:    Translation:HumansCells
  82. van Deursen FJ, Thornton DJ, Matthews KR. A reproducible protocol for analysis of the proteome of Trypanosoma brucei by 2-dimensional gel electrophoresis. Mol Biochem Parasitol. 2003 Apr 25; 128(1):107-10. PMID: 12706805.
    Citations: 2     Fields:    Translation:AnimalsCells
  83. Fleming CA, Craven DE, Thornton D, Tumilty S, Nunes D. Hepatitis C virus and human immunodeficiency virus coinfection in an urban population: low eligibility for interferon treatment. Clin Infect Dis. 2003 Jan 01; 36(1):97-100. PMID: 12491208.
    Citations: 37     Fields:    Translation:Humans
  84. Craven DE, De Rosa FG, Thornton D. Nosocomial pneumonia: emerging concepts in diagnosis, management, and prophylaxis. Curr Opin Crit Care. 2002 Oct; 8(5):421-9. PMID: 12357110.
    Citations: 3     Fields:    Translation:Humans
  85. Vial S, Lu H, Allen S, Savory P, Thornton D, Sheehan J, Tokatlidis K. Assembly of Tim9 and Tim10 into a functional chaperone. J Biol Chem. 2002 Sep 27; 277(39):36100-8. PMID: 12138093.
    Citations: 23     Fields:    Translation:Cells
  86. Raynal BD, Hardingham TE, Thornton DJ, Sheehan JK. Concentrated solutions of salivary MUC5B mucin do not replicate the gel-forming properties of saliva. Biochem J. 2002 Mar 01; 362(Pt 2):289-96. PMID: 11853536; PMCID: PMC1222388.
    Citations: 17     Fields:    Translation:HumansCells
  87. Kirkham S, Sheehan JK, Knight D, Richardson PS, Thornton DJ. Heterogeneity of airways mucus: variations in the amounts and glycoforms of the major oligomeric mucins MUC5AC and MUC5B. Biochem J. 2002 Feb 01; 361(Pt 3):537-46. PMID: 11802783; PMCID: PMC1222336.
    Citations: 125     Fields:    Translation:Humans
  88. Thornton DJ, Davies JR, Kirkham S, Gautrey A, Khan N, Richardson PS, Sheehan JK. Identification of a nonmucin glycoprotein (gp-340) from a purified respiratory mucin preparation: evidence for an association involving the MUC5B mucin. Glycobiology. 2001 Nov; 11(11):969-77. PMID: 11744631.
    Citations: 22     Fields:    Translation:HumansCells
  89. Tselepis C, Kwan AP, Thornton D, Sheehan J. The biochemical characterization of aggrecan from normal and tibial-dyschondroplastic chicken growth-plate cartilage. Biochem J. 2000 Oct 15; 351 Pt 2:517-25. PMID: 11023839; PMCID: PMC1221389.
    Citations: 1     Fields:    Translation:Animals
  90. Thornton DJ, Gray T, Nettesheim P, Howard M, Koo JS, Sheehan JK. Characterization of mucins from cultured normal human tracheobronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2000 Jun; 278(6):L1118-28. PMID: 10835316.
    Citations: 41     Fields:    Translation:HumansCells
  91. Sheehan JK, Brazeau C, Kutay S, Pigeon H, Kirkham S, Howard M, Thornton DJ. Physical characterization of the MUC5AC mucin: a highly oligomeric glycoprotein whether isolated from cell culture or in vivo from respiratory mucous secretions. Biochem J. 2000 Apr 01; 347 Pt 1:37-44. PMID: 10727399; PMCID: PMC1220928.
    Citations: 34     Fields:    Translation:HumansCells
  92. Reardon AJ, Le Goff M, Briggs MD, McLeod D, Sheehan JK, Thornton DJ, Bishop PN. Identification in vitreous and molecular cloning of opticin, a novel member of the family of leucine-rich repeat proteins of the extracellular matrix. J Biol Chem. 2000 Jan 21; 275(3):2123-9. PMID: 10636917.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  93. McGuckin MA, Thornton DJ. Detection and quantitation of mucins using chemical, lectin, and antibody methods. Methods Mol Biol. 2000; 125:45-55. PMID: 10820748.
    Citations: 7     Fields:    Translation:HumansAnimals
  94. Sheehan JK, Thornton DJ. Heterogeneity and size distribution of gel-forming mucins. Methods Mol Biol. 2000; 125:87-96. PMID: 10820752.
    Citations: 7     Fields:    Translation:Humans
  95. Thornton DJ, Khan N, Sheehan JK. Separation and identification of mucins and their glycoforms. Methods Mol Biol. 2000; 125:77-85. PMID: 10820751.
    Citations: 11     Fields:    Translation:Humans
  96. Aksoy N, Thornton DJ, Corfield A, Paraskeva C, Sheehan JK. A study of the intracellular and secreted forms of the MUC2 mucin from the PC/AA intestinal cell line. Glycobiology. 1999 Jul; 9(7):739-46. PMID: 10362844.
    Citations: 11     Fields:    Translation:HumansCells
  97. Thornton DJ, Khan N, Mehrotra R, Howard M, Veerman E, Packer NH, Sheehan JK. Salivary mucin MG1 is comprised almost entirely of different glycosylated forms of the MUC5B gene product. Glycobiology. 1999 Mar; 9(3):293-302. PMID: 10024667.
    Citations: 44     Fields:    Translation:HumansCells
  98. Sheehan JK, Howard M, Richardson PS, Longwill T, Thornton DJ. Physical characterization of a low-charge glycoform of the MUC5B mucin comprising the gel-phase of an asthmatic respiratory mucous plug. Biochem J. 1999 Mar 01; 338 ( Pt 2):507-13. PMID: 10024529; PMCID: PMC1220079.
    Citations: 29     Fields:    Translation:Humans
  99. Devine PL, Quin RJ, Shield PW, Liew YW, Sheehan JK, Thornton DJ. Monoclonal antibody recognizing a core epitope on mucin. Dis Markers. 1998 Oct; 14(2):99-112. PMID: 9868597; PMCID: PMC3850846.
    Citations:    Fields:    Translation:AnimalsCells
  100. Mehrotra R, Thornton DJ, Sheehan JK. Isolation and physical characterization of the MUC7 (MG2) mucin from saliva: evidence for self-association. Biochem J. 1998 Sep 01; 334 ( Pt 2):415-22. PMID: 9716500; PMCID: PMC1219704.
    Citations: 17     Fields:    Translation:HumansCells
  101. Hanna AN, Waldman WJ, Lott JA, Koesters SC, Hughes AM, Thornton DJ. Increased alkaline phosphatase isoforms in autoimmune diseases. Clin Chem. 1997 Aug; 43(8 Pt 1):1357-64. PMID: 9267314.
    Citations: 2     Fields:    Translation:HumansCells
  102. Thornton DJ, Howard M, Khan N, Sheehan JK. Identification of two glycoforms of the MUC5B mucin in human respiratory mucus. Evidence for a cysteine-rich sequence repeated within the molecule. J Biol Chem. 1997 Apr 04; 272(14):9561-6. PMID: 9083100.
    Citations: 50     Fields:    Translation:HumansCells
  103. Thornton DJ, Carlstedt I, Howard M, Devine PL, Price MR, Sheehan JK. Respiratory mucins: identification of core proteins and glycoforms. Biochem J. 1996 Jun 15; 316 ( Pt 3):967-75. PMID: 8670177; PMCID: PMC1217443.
    Citations: 55     Fields:    Translation:HumansAnimalsCells
  104. Sheehan JK, Thornton DJ, Howard M, Carlstedt I, Corfield AP, Paraskeva C. Biosynthesis of the MUC2 mucin: evidence for a slow assembly of fully glycosylated units. Biochem J. 1996 May 01; 315 ( Pt 3):1055-60. PMID: 8645144; PMCID: PMC1217261.
    Citations: 7     Fields:    Translation:HumansCells
  105. Thornton DJ, Carlstedt I, Sheehan JK. Identification of glycoproteins on nitrocellulose membranes and gels. Mol Biotechnol. 1996 Apr; 5(2):171-6. PMID: 8734429.
    Citations: 16     Fields:    
  106. Sheehan JK, Richardson PS, Fung DC, Howard M, Thornton DJ. Analysis of respiratory mucus glycoproteins in asthma: a detailed study from a patient who died in status asthmaticus. Am J Respir Cell Mol Biol. 1995 Dec; 13(6):748-56. PMID: 7576713.
    Citations: 32     Fields:    Translation:Humans
  107. Sheehan JK, Hanski C, Corfield AP, Paraskeva C, Thornton DJ. Mucin biosynthesis and macromolecular assembly. Biochem Soc Trans. 1995 Nov; 23(4):819-21. PMID: 8654845.
    Citations: 3     Fields:    Translation:HumansCells
  108. Thornton DJ, Howard M, Devine PL, Sheehan JK. Methods for separation and deglycosylation of mucin subunits. Anal Biochem. 1995 May 01; 227(1):162-7. PMID: 7668377.
    Citations: 23     Fields:    Translation:Humans
  109. Thornton DJ, Devine PL, Hanski C, Howard M, Sheehan JK. Identification of two major populations of mucins in respiratory secretions. Am J Respir Crit Care Med. 1994 Sep; 150(3):823-32. PMID: 8087358.
    Citations: 17     Fields:    Translation:Humans
  110. Thornton DJ, Carlstedt I, Sheehan JK. Identification of glycoproteins on nitrocellulose membranes and gels. Methods Mol Biol. 1994; 32:119-28. PMID: 7524938.
    Citations: 11     Fields:    
  111. Lucas JM, Bryans M, Lo K, Wilkie NM, Freshney M, Thornton D, Lang JC. The FGF-4 promoter is required for transformation and is active in both embryonal and somatic cells. Oncol Res. 1994; 6(3):139-49. PMID: 7994085.
    Citations:    Fields:    Translation:HumansAnimalsCells
  112. Hamoudi AC, Singley CT, Teitelbaum DH, Thornton DJ, Broner CW. Intravascular calcium deposits in a critically ill patient. Light- and electron-microscopic findings. Arch Pathol Lab Med. 1993 Dec; 117(12):1257-60. PMID: 8250700.
    Citations:    Fields:    Translation:Humans
  113. Sheehan JK, Thornton DJ, Somerville M, Carlstedt I. Mucin structure. The structure and heterogeneity of respiratory mucus glycoproteins. Am Rev Respir Dis. 1991 Sep; 144(3 Pt 2):S4-9. PMID: 1892325.
    Citations: 20     Fields:    Translation:Humans
  114. Thornton DJ, Sheehan JK, Lindgren H, Carlstedt I. Mucus glycoproteins from cystic fibrotic sputum. Macromolecular properties and structural 'architecture'. Biochem J. 1991 Jun 15; 276 ( Pt 3):667-75. PMID: 2064605; PMCID: PMC1151057.
    Citations: 19     Fields:    Translation:Humans
  115. Thornton DJ, Sheehan JK, Carlstedt I. Heterogeneity of mucus glycoproteins from cystic fibrotic sputum. Are there different families of mucins? Biochem J. 1991 Jun 15; 276 ( Pt 3):677-82. PMID: 2064606; PMCID: PMC1151058.
    Citations: 11     Fields:    Translation:Humans
  116. Sheehan JK, Boot-Handford RP, Chantler E, Carlstedt I, Thornton DJ. Evidence for shared epitopes within the 'naked' protein domains of human mucus glycoproteins. A study performed by using polyclonal antibodies and electron microscopy. Biochem J. 1991 Feb 15; 274 ( Pt 1):293-6. PMID: 1705799; PMCID: PMC1149952.
    Citations: 11     Fields:    Translation:Humans
  117. Cromer BA, Tarnowski KJ, Stein AM, Harton P, Thornton DJ. The school breakfast program and cognition in adolescents. J Dev Behav Pediatr. 1990 Dec; 11(6):295-300. PMID: 2289961.
    Citations: 5     Fields:    Translation:Humans
  118. Nelson JW, Tredgett MW, Sheehan JK, Thornton DJ, Notman D, Govan JR. Mucinophilic and chemotactic properties of Pseudomonas aeruginosa in relation to pulmonary colonization in cystic fibrosis. Infect Immun. 1990 Jun; 58(6):1489-95. PMID: 2111280.
    Citations: 21     Fields:    Translation:HumansCells
  119. Sheehan JK, Thornton DJ, Carlstedt I. Histochemical methods used in biochemical approaches to mucus glycoproteins. Acta Histochem Suppl. 1990; 40:133-5. PMID: 2091040.
    Citations: 1     Fields:    Translation:Humans
  120. Thornton DJ, Davies JR, Kraayenbrink M, Richardson PS, Sheehan JK, Carlstedt I. Mucus glycoproteins from 'normal' human tracheobronchial secretion. Biochem J. 1990 Jan 01; 265(1):179-86. PMID: 2302164; PMCID: PMC1136628.
    Citations: 45     Fields:    Translation:Humans
  121. Stump DC, Califf RM, Topol EJ, Sigmon K, Thornton D, Masek R, Anderson L, Collen D. Pharmacodynamics of thrombolysis with recombinant tissue-type plasminogen activator. Correlation with characteristics of and clinical outcomes in patients with acute myocardial infarction. The TAMI Study Group. Circulation. 1989 Nov; 80(5):1222-30. PMID: 2509104.
    Citations: 9     Fields:    Translation:Humans
  122. Thornton DJ, Holmes DF, Sheehan JK, Carlstedt I. Quantitation of mucus glycoproteins blotted onto nitrocellulose membranes. Anal Biochem. 1989 Oct; 182(1):160-4. PMID: 2604041.
    Citations: 43     Fields:    
  123. Thornton DJ, Morris HG, Cockin GH, Huckerby TN, Nieduszynski IA, Carlstedt I, Hardingham TE, Ratcliffe A. Structural and immunological studies of keratan sulphates from mature bovine articular cartilage. Biochem J. 1989 May 15; 260(1):277-82. PMID: 2528344; PMCID: PMC1138657.
    Citations: 10     Fields:    Translation:Animals
  124. Long JF, Steinmeyer CL, Thornton DJ, Nagode LA. Serum calcitriol and parathyroid hormone levels following prolonged infusion of calcitriol in vitamin D replete and depleted rabbits. Res Commun Chem Pathol Pharmacol. 1989 May; 64(2):273-86. PMID: 2740619.
    Citations:    Fields:    Translation:Animals
  125. Cromer BA, Steinberg K, Gardner L, Thornton D, Shannon B. Psychosocial determinants of compliance in adolescents with iron deficiency. Am J Dis Child. 1989 Jan; 143(1):55-8. PMID: 2910045.
    Citations: 3     Fields:    Translation:Humans
  126. Thornton DJ, Morris HG, Cockin GH, Huckerby TN, Nieduszynski IA. Structural studies of two populations of keratan sulphate chains from mature bovine articular cartilage. Glycoconj J. 1989; 6(2):209-18. PMID: 2535485.
    Citations: 7     Fields:    Translation:Animals
  127. Shenep JL, Kalwinsky DK, Hutson PR, George SL, Dodge RK, Blankenship KR, Thornton D. Efficacy of oral sucralfate suspension in prevention and treatment of chemotherapy-induced mucositis. J Pediatr. 1988 Oct; 113(4):758-63. PMID: 3050005.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  128. Garabedian HD, Gold HK, Leinbach RC, Yasuda T, Johns JA, Thornton D, Collen D. Laboratory monitoring of hemostasis during thrombolytic therapy with recombinant human tissue-type plasminogen activator. Thromb Res. 1988 Apr 01; 50(1):121-33. PMID: 3135634.
    Citations: 4     Fields:    Translation:Humans
  129. Thornton DJ, Sheehan JK, Nieduszynski IA. A study of the interaction between cartilage proteoglycan and link protein. Biochem J. 1987 Dec 15; 248(3):943-51. PMID: 3435493; PMCID: PMC1148641.
    Citations: 3     Fields:    Translation:AnimalsCells
  130. Bassett ME, Thornton DJ, Sheehan JK, Nieduszynski IA. An enzyme-linked immunosorbent assay (ELISA) of denatured cartilage link protein. Biochim Biophys Acta. 1987 Sep 11; 925(3):347-55. PMID: 3620506.
    Citations: 2     Fields:    Translation:AnimalsCells
  131. Thornton DJ, Nieduszynski IA, Oates K, Sheehan JK. Electron-microscopic and electrophoretic studies of bovine femoral-head cartilage proteoglycan fractions. Biochem J. 1986 Nov 15; 240(1):41-8. PMID: 3827853; PMCID: PMC1147373.
    Citations: 7     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.