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Satish K Singh, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Dubey SR, Chakraborty S, Roy SK, Mukherjee S, Singh SK, Chaudhuri BB. diffGrad: An Optimization Method for Convolutional Neural Networks. IEEE Trans Neural Netw Learn Syst. 2020 11; 31(11):4500-4511. PMID: 31880565.
    Citations: 7     Fields:    
  2. Authelin JR, Rodrigues MA, Tchessalov S, Singh SK, McCoy T, Wang S, Shalaev E. Freezing of Biologicals Revisited: Scale, Stability, Excipients, and Degradation Stresses. J Pharm Sci. 2020 01; 109(1):44-61. PMID: 31705870.
    Citations: 8     Fields:    Translation:HumansCells
  3. Langer C, Mahler HC, Koulov A, Marti N, Grigore C, Matter A, Chalus P, Singh S, Lemazurier T, Joerg S, Mathaes R. Method to Predict Glass Vial Fogging in Lyophilized Drug Products. J Pharm Sci. 2020 01; 109(1):323-330. PMID: 31473212.
    Citations: 1     Fields:    
  4. Chattopadhyay A, Singh AP, Singh SK, Barman A, Patra A, Mondal BP, Banerjee K. Spatial variability of arsenic in Indo-Gangetic basin of Varanasi and its cancer risk assessment. Chemosphere. 2020 Jan; 238:124623. PMID: 31545212.
    Citations: 1     Fields:    Translation:HumansPHPublic Health
  5. Matter A, Koulov A, Singh S, Mahler HC, Reinisch H, Langer C, Zucol B, Mathaes R. Variance Between Different Light Obscuration and Flow Imaging Microscopy Instruments and the Impact of Instrument Calibration. J Pharm Sci. 2019 07; 108(7):2397-2405. PMID: 30844365.
    Citations:    Fields:    
  6. Tomar DS, Singh SK, Li L, Broulidakis MP, Kumar S. In Silico Prediction of Diffusion Interaction Parameter (kD), a Key Indicator of Antibody Solution Behaviors. Pharm Res. 2018 Aug 20; 35(10):193. PMID: 30128780.
    Citations: 8     Fields:    Translation:Cells
  7. Singh SK, Mahler HC, Hartman C, Stark CA. Are Injection Site Reactions in Monoclonal Antibody Therapies Caused by Polysorbate Excipient Degradants? J Pharm Sci. 2018 11; 107(11):2735-2741. PMID: 30055223.
    Citations: 7     Fields:    Translation:HumansCells
  8. Peláez SS, Mahler HC, Matter A, Koulov A, Singh SK, Germershaus O, Mathaes R. Container Closure Integrity Testing of Prefilled Syringes. J Pharm Sci. 2018 08; 107(8):2091-2097. PMID: 29626532.
    Citations: 1     Fields:    Translation:Humans
  9. Agarwal G, Singh SK. An Intriguing Family with Type 2 Diabetes Mellitus and Complete Heart Block. Indian J Endocrinol Metab. 2017 Sep-Oct; 21(5):784-786. PMID: 28989893.
  10. Agarwal G, Singh SK. Arrhythmias in Type 2 Diabetes Mellitus. Indian J Endocrinol Metab. 2017 Sep-Oct; 21(5):715-718. PMID: 28989880.
    Citations: 7     
  11. Khan SR, Singh SK, Rastogi N. Heavy metal accumulation and ecosystem engineering by two common mine site-nesting ant species: implications for pollution-level assessment and bioremediation of coal mine soil. Environ Monit Assess. 2017 Apr; 189(4):195. PMID: 28357721.
    Citations:    Fields:    Translation:AnimalsPHPublic Health
  12. Kumar S, Plotnikov NV, Rouse JC, Singh SK. Biopharmaceutical Informatics: supporting biologic drug development via molecular modelling and informatics. J Pharm Pharmacol. 2018 May; 70(5):595-608. PMID: 28155992.
    Citations: 10     Fields:    Translation:Humans
  13. Tomar DS, Li L, Broulidakis MP, Luksha NG, Burns CT, Singh SK, Kumar S. In-silico prediction of concentration-dependent viscosity curves for monoclonal antibody solutions. MAbs. 2017 04; 9(3):476-489. PMID: 28125318.
    Citations: 19     Fields:    Translation:HumansAnimals
  14. Plotnikov NV, Singh SK, Rouse JC, Kumar S. Quantifying the Risks of Asparagine Deamidation and Aspartate Isomerization in Biopharmaceuticals by Computing Reaction Free-Energy Surfaces. J Phys Chem B. 2017 02 02; 121(4):719-730. PMID: 28051868.
    Citations: 4     Fields:    Translation:Cells
  15. Weiss WF, Gabrielson JP, Al-Azzam W, Chen G, Davis DL, Das TK, Hayes DB, Houde D, Singh SK. Technical Decision Making With Higher Order Structure Data: Perspectives on Higher Order Structure Characterization From the Biopharmaceutical Industry. J Pharm Sci. 2016 12; 105(12):3465-3470. PMID: 27743675.
    Citations: 9     Fields:    Translation:HumansAnimals
  16. Dubey SR, Singh SK, Singh RK. Multichannel Decoded Local Binary Patterns for Content-Based Image Retrieval. IEEE Trans Image Process. 2016 09; 25(9):4018-32. PMID: 27295674.
    Citations: 5     Fields:    
  17. Kumar S, Thangakani AM, Nagarajan R, Singh SK, Velmurugan D, Gromiha MM. Autoimmune Responses to Soluble Aggregates of Amyloidogenic Proteins Involved in Neurodegenerative Diseases: Overlapping Aggregation Prone and Autoimmunogenic regions. Sci Rep. 2016 Feb 29; 6:22258. PMID: 26924748.
    Citations: 1     Fields:    Translation:HumansCells
  18. Guo J, Kumar S, Chipley M, Marcq O, Gupta D, Jin Z, Tomar DS, Swabowski C, Smith J, Starkey JA, Singh SK. Characterization and Higher-Order Structure Assessment of an Interchain Cysteine-Based ADC: Impact of Drug Loading and Distribution on the Mechanism of Aggregation. Bioconjug Chem. 2016 Mar 16; 27(3):604-15. PMID: 26829368.
    Citations: 13     Fields:    Translation:Cells
  19. Tomar DS, Kumar S, Singh SK, Goswami S, Li L. Molecular basis of high viscosity in concentrated antibody solutions: Strategies for high concentration drug product development. MAbs. 2016; 8(2):216-28. PMID: 26736022.
    Citations: 39     Fields:    Translation:HumansAnimals
  20. Dubey SR, Singh SK, Singh RK. Local Wavelet Pattern: A New Feature Descriptor for Image Retrieval in Medical CT Databases. IEEE Trans Image Process. 2015 Dec; 24(12):5892-903. PMID: 26513789.
    Citations: 6     Fields:    Translation:Humans
  21. Singh SK, Luisi DL, Pak RH. Antibody-Drug Conjugates: Design, Formulation and Physicochemical Stability. Pharm Res. 2015 Nov; 32(11):3541-71. PMID: 25986175.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  22. Singh R, Allam BK, Singh N, Kumari K, Singh SK, Singh KN. A Direct Metal-Free Decarboxylative Sulfono Functionalization (DSF) of Cinnamic Acids to a,ß-Unsaturated Phenyl Sulfones. Org Lett. 2015 Jun 05; 17(11):2656-9. PMID: 25954832.
    Citations: 6     Fields:    
  23. Narhi LO, Corvari V, Ripple DC, Afonina N, Cecchini I, Defelippis MR, Garidel P, Herre A, Koulov AV, Lubiniecki T, Mahler HC, Mangiagalli P, Nesta D, Perez-Ramirez B, Polozova A, Rossi M, Schmidt R, Simler R, Singh S, Spitznagel TM, Weiskopf A, Wuchner K. Subvisible (2-100 µm) Particle Analysis During Biotherapeutic Drug Product Development: Part 1, Considerations and Strategy. J Pharm Sci. 2015 Jun; 104(6):1899-1908. PMID: 25832583.
    Citations: 6     Fields:    Translation:HumansAnimals
  24. Nichols P, Li L, Kumar S, Buck PM, Singh SK, Goswami S, Balthazor B, Conley TR, Sek D, Allen MJ. Rational design of viscosity reducing mutants of a monoclonal antibody: hydrophobic versus electrostatic inter-molecular interactions. MAbs. 2015; 7(1):212-30. PMID: 25559441.
    Citations: 35     Fields:    Translation:Humans
  25. Dubey SR, Singh SK, Singh RK. Rotation and illumination invariant interleaved intensity order-based local descriptor. IEEE Trans Image Process. 2014 Dec; 23(12):5323-33. PMID: 25248185.
    Citations:    Fields:    
  26. Buck PM, Chaudhri A, Kumar S, Singh SK. Highly viscous antibody solutions are a consequence of network formation caused by domain-domain electrostatic complementarities: insights from coarse-grained simulations. Mol Pharm. 2015 Jan 05; 12(1):127-39. PMID: 25383990.
    Citations: 22     Fields:    Translation:HumansCells
  27. Kumar B, Verma VK, Singh SK, Kumar S, Sharma CS, Akolkar AB. Polychlorinated Biphenyls in Residential Soils and their Health Risk and Hazard in an Industrial City in India. J Public Health Res. 2014 Jul 02; 3(2):252. PMID: 25343135.
    Citations: 3     
  28. Li L, Kumar S, Buck PM, Burns C, Lavoie J, Singh SK, Warne NW, Nichols P, Luksha N, Boardman D. Concentration dependent viscosity of monoclonal antibody solutions: explaining experimental behavior in terms of molecular properties. Pharm Res. 2014 Nov; 31(11):3161-78. PMID: 24906598.
    Citations: 37     Fields:    Translation:Cells
  29. Guo J, Kumar S, Prashad A, Starkey J, Singh SK. Assessment of physical stability of an antibody drug conjugate by higher order structure analysis: impact of thiol- maleimide chemistry. Pharm Res. 2014 Jul; 31(7):1710-23. PMID: 24464270.
    Citations: 17     Fields:    Translation:Cells
  30. Kumar S, Zhou S, Singh SK. Metal ion leachates and the physico-chemical stability of biotherapeutic drug products. Curr Pharm Des. 2014; 20(8):1173-81. PMID: 23713770.
    Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
  31. Buck PM, Kumar S, Singh SK. Consequences of glycan truncation on Fc structural integrity. MAbs. 2013 Nov-Dec; 5(6):904-16. PMID: 24492344.
    Citations: 11     Fields:    Translation:HumansCells
  32. Buck PM, Kumar S, Singh SK. On the role of aggregation prone regions in protein evolution, stability, and enzymatic catalysis: insights from diverse analyses. PLoS Comput Biol. 2013; 9(10):e1003291. PMID: 24146608.
    Citations: 16     Fields:    Translation:Cells
  33. Rosa M, Lopes C, Melo EP, Singh SK, Geraldes V, Rodrigues MA. Measuring and modeling hemoglobin aggregation below the freezing temperature. J Phys Chem B. 2013 Aug 01; 117(30):8939-46. PMID: 23808610.
    Citations: 4     Fields:    Translation:AnimalsCells
  34. Miller MA, Rodrigues MA, Glass MA, Singh SK, Johnston KP, Maynard JA. Frozen-state storage stability of a monoclonal antibody: aggregation is impacted by freezing rate and solute distribution. J Pharm Sci. 2013 Apr; 102(4):1194-208. PMID: 23400717.
    Citations: 17     Fields:    Translation:Cells
  35. Tewary K, Singh VK, Singh SK, Tiwary P, Garg A, Joshi KK. Epidemiology of diabetes mellitus in young population in rural districts of northern Bihar. J Indian Med Assoc. 2013 Feb; 111(2):103-6. PMID: 24003567.
    Citations:    Fields:    Translation:Humans
  36. Buck PM, Kumar S, Singh SK. Insights into the potential aggregation liabilities of the b12 Fab fragment via elevated temperature molecular dynamics. Protein Eng Des Sel. 2013 Mar; 26(3):195-205. PMID: 23188804.
    Citations: 9     Fields:    Translation:HumansCells
  37. Wang X, Kumar S, Buck PM, Singh SK. Impact of deglycosylation and thermal stress on conformational stability of a full length murine IgG2a monoclonal antibody: observations from molecular dynamics simulations. Proteins. 2013 Mar; 81(3):443-60. PMID: 23065923.
    Citations: 16     Fields:    Translation:AnimalsCells
  38. Barbosa MD, Kumar S, Loughrey H, Singh SK. Biosimilars and biobetters as tools for understanding and mitigating the immunogenicity of biotherapeutics. Drug Discov Today. 2012 Dec; 17(23-24):1282-8. PMID: 22796124.
    Citations: 7     Fields:    Translation:Humans
  39. Singh SK, Cousens LP, Alvarez D, Mahajan PB. Determinants of immunogenic response to protein therapeutics. Biologicals. 2012 Sep; 40(5):364-8. PMID: 22770604.
    Citations: 6     Fields:    Translation:HumansAnimalsPHPublic Health
  40. Li N, Osborne B, Singh SK, Wang W. Metal-leachate-induced conjugate protein instability. J Pharm Sci. 2012 Aug; 101(8):2733-43. PMID: 22644953.
    Citations:    Fields:    Translation:Cells
  41. Kumar S, Mitchell MA, Rup B, Singh SK. Relationship between potential aggregation-prone regions and HLA-DR-binding T-cell immune epitopes: implications for rational design of novel and follow-on therapeutic antibodies. J Pharm Sci. 2012 Aug; 101(8):2686-701. PMID: 22619033.
    Citations: 9     Fields:    Translation:HumansCells
  42. Wang W, Singh SK, Li N, Toler MR, King KR, Nema S. Immunogenicity of protein aggregates--concerns and realities. Int J Pharm. 2012 Jul 15; 431(1-2):1-11. PMID: 22546296.
    Citations: 47     Fields:    Translation:HumansAnimalsCells
  43. Zhou S, Evans B, Schöneich C, Singh SK. Biotherapeutic formulation factors affecting metal leachables from stainless steel studied by design of experiments. AAPS PharmSciTech. 2012 Mar; 13(1):284-94. PMID: 22246735.
    Citations: 4     Fields:    Translation:PHPublic Health
  44. Buck PM, Kumar S, Wang X, Agrawal NJ, Trout BL, Singh SK. Computational methods to predict therapeutic protein aggregation. Methods Mol Biol. 2012; 899:425-51. PMID: 22735968.
    Citations: 23     Fields:    Translation:HumansCells
  45. Singh SK, Toler MR. Monitoring of subvisible particles in therapeutic proteins. Methods Mol Biol. 2012; 899:379-401. PMID: 22735966.
    Citations: 2     Fields:    Translation:HumansPHPublic Health
  46. Booker RD, Koh CA, Sloan ED, Sum AK, Shalaev E, Singh SK. Xenon hydrate dissociation measurements with model protein systems. J Phys Chem B. 2011 Sep 01; 115(34):10270-6. PMID: 21790193.
    Citations:    Fields:    Translation:Animals
  47. Zhang A, Singh SK, Shirts MR, Kumar S, Fernandez EJ. Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange. Pharm Res. 2012 Jan; 29(1):236-50. PMID: 21805212.
    Citations: 41     Fields:    Translation:HumansCells
  48. Agrawal NJ, Kumar S, Wang X, Helk B, Singh SK, Trout BL. Aggregation in protein-based biotherapeutics: computational studies and tools to identify aggregation-prone regions. J Pharm Sci. 2011 Dec; 100(12):5081-95. PMID: 21789769.
    Citations: 45     Fields:    Translation:HumansCells
  49. Huang M, Horwitz TS, Zweiben C, Singh SK. Impact of extractables/leachables from filters on stability of protein formulations. J Pharm Sci. 2011 Nov; 100(11):4617-30. PMID: 21695696.
    Citations: 1     Fields:    Translation:Cells
  50. Wang X, Kumar S, Singh SK. Disulfide scrambling in IgG2 monoclonal antibodies: insights from molecular dynamics simulations. Pharm Res. 2011 Dec; 28(12):3128-44. PMID: 21671135.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  51. Kumar S, Singh SK, Wang X, Rup B, Gill D. Coupling of aggregation and immunogenicity in biotherapeutics: T- and B-cell immune epitopes may contain aggregation-prone regions. Pharm Res. 2011 May; 28(5):949-61. PMID: 21437790.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  52. Zhou S, Schöneich C, Singh SK. Biologics formulation factors affecting metal leachables from stainless steel. AAPS PharmSciTech. 2011 Mar; 12(1):411-21. PMID: 21360314.
    Citations: 5     Fields:    Translation:HumansPHPublic Health
  53. Rodrigues MA, Miller MA, Glass MA, Singh SK, Johnston KP. Effect of freezing rate and dendritic ice formation on concentration profiles of proteins frozen in cylindrical vessels. J Pharm Sci. 2011 Apr; 100(4):1316-29. PMID: 24081467.
    Citations: 6     Fields:    Translation:AnimalsCells
  54. Zhou S, Zhang B, Sturm E, Teagarden DL, Schöneich C, Kolhe P, Lewis LM, Muralidhara BK, Singh SK. Comparative evaluation of disodium edetate and diethylenetriaminepentaacetic acid as iron chelators to prevent metal-catalyzed destabilization of a therapeutic monoclonal antibody. J Pharm Sci. 2010 Oct; 99(10):4239-50. PMID: 20737631.
    Citations: 9     Fields:    Translation:Cells
  55. Barnard JG, Singh S, Randolph TW, Carpenter JF. Subvisible particle counting provides a sensitive method of detecting and quantifying aggregation of monoclonal antibody caused by freeze-thawing: insights into the roles of particles in the protein aggregation pathway. J Pharm Sci. 2011 Feb; 100(2):492-503. PMID: 20803602.
    Citations: 31     Fields:    Translation:Cells
  56. Singh SK. Impact of product-related factors on immunogenicity of biotherapeutics. J Pharm Sci. 2011 Feb; 100(2):354-87. PMID: 20740683.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  57. Singh SK, Afonina N, Awwad M, Bechtold-Peters K, Blue JT, Chou D, Cromwell M, Krause HJ, Mahler HC, Meyer BK, Narhi L, Nesta DP, Spitznagel T. An industry perspective on the monitoring of subvisible particles as a quality attribute for protein therapeutics. J Pharm Sci. 2010 Aug; 99(8):3302-21. PMID: 20310025.
    Citations: 51     Fields:    Translation:HumansAnimals
  58. Kolhe P, Amend E, Singh SK. Impact of freezing on pH of buffered solutions and consequences for monoclonal antibody aggregation. Biotechnol Prog. 2010 May-Jun; 26(3):727-33. PMID: 20039442.
    Citations: 29     Fields:    Translation:Cells
  59. Wang X, Singh SK, Kumar S. Potential aggregation-prone regions in complementarity-determining regions of antibodies and their contribution towards antigen recognition: a computational analysis. Pharm Res. 2010 Aug; 27(8):1512-29. PMID: 20422267.
    Citations: 25     Fields:    Translation:HumansCells
  60. Wang X, Das TK, Singh SK, Kumar S. Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies. MAbs. 2009 May-Jun; 1(3):254-67. PMID: 20065649.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  61. Wang W, Singh S, Zeng DL, King K, Nema S. Antibody structure, instability, and formulation. J Pharm Sci. 2007 Jan; 96(1):1-26. PMID: 16998873.
    Citations: 185     Fields:    Translation:Cells
  62. Goyal PK, Singh SK, Sharma MK, Rupert E. Giant left anterior descending artery aneurysm. Ann Card Anaesth. 2006 Jul; 9(2):155. PMID: 17699899.
    Citations:    Fields:    
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.