Harvard Catalyst Profiles

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Isaac Chiu, Ph.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK127257 (CHIU, ISAAC MING-CHENG) Jan 1, 2021 - Nov 30, 2024
    Nociceptor neuron regulation of gastrointestinal barrier protection and host defense
    Role: Principal Investigator
  2. R21AT010774 (QUAVE, CASSANDRA LEAH) Sep 15, 2019 - Aug 31, 2021
    Mechanistic studies on analgesic effects of terpene enriched extracts from hops
    Role: Co-Principal Investigator
  3. R01AI130019 (CHIU, ISAAC MING-CHENG) Sep 25, 2017 - Aug 31, 2022
    Pain and Neuro-immune Signaling in S. pyogenes pathogenesis
    Role: Principal Investigator
  4. DP2AT009499 (CHIU, ISAAC MING-CHENG) Sep 30, 2016 - Jun 30, 2021
    Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota
    Role: Principal Investigator
  5. K22AI114810 (CHIU, ISAAC MING-CHENG) Apr 15, 2015 - Mar 31, 2017
    The role of nociceptor neurons in bacterial host defense and inflammation
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Staurengo-Ferrari L, Deng L, Chiu IM. Interactions between nociceptor sensory neurons and microbial pathogens in pain. Pain. 2022 11 01; 163(Suppl 1):S57-S68. PMID: 36252233; PMCID: PMC9586460.
    Citations:    Fields:    Translation:HumansCells
  2. Yang D, Jacobson A, Meerschaert KA, Sifakis JJ, Wu M, Chen X, Yang T, Zhou Y, Anekal PV, Rucker RA, Sharma D, Sontheimer-Phelps A, Wu GS, Deng L, Anderson MD, Choi S, Neel D, Lee N, Kasper DL, Jabri B, Huh JR, Johansson M, Thiagarajah JR, Riesenfeld SJ, Chiu IM. Nociceptor neurons direct goblet cells via a CGRP-RAMP1 axis to drive mucus production and gut barrier protection. Cell. 2022 Oct 27; 185(22):4190-4205.e25. PMID: 36243004; PMCID: PMC9617795.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  3. Chiu IM, Liblau R. Editorial overview: Special section neuroimmunology: Neuroimmune interactions in health and disease. Curr Opin Immunol. 2022 08; 77:102232. PMID: 35792467.
    Citations:    Fields:    
  4. Chen X, Ravindra Kumar S, Adams CD, Yang D, Wang T, Wolfe DA, Arokiaraj CM, Ngo V, Campos LJ, Griffiths JA, Ichiki T, Mazmanian SK, Osborne PB, Keast JR, Miller CT, Fox AS, Chiu IM, Gradinaru V. Engineered AAVs for non-invasive gene delivery to rodent and non-human primate nervous systems. Neuron. 2022 07 20; 110(14):2242-2257.e6. PMID: 35643078; PMCID: PMC9308721.
    Citations: 4     Fields:    Translation:AnimalsCells
  5. Neel DV, Basu H, Gunner G, Chiu IM. Catching a killer: Mechanisms of programmed cell death and immune activation in Amyotrophic Lateral Sclerosis. Immunol Rev. 2022 10; 311(1):130-150. PMID: 35524757; PMCID: PMC9489610.
    Citations:    Fields:    
  6. Deng L, Chiu IM. A neuropeptide regulates immunity across species. Neuron. 2022 04 20; 110(8):1275-1277. PMID: 35447095.
    Citations:    Fields:    Translation:Cells
  7. Klein Wolterink RGJ, Wu GS, Chiu IM, Veiga-Fernandes H. Neuroimmune Interactions in Peripheral Organs. Annu Rev Neurosci. 2022 07 08; 45:339-360. PMID: 35363534; PMCID: PMC9436268.
    Citations: 2     Fields:    
  8. Udit S, Blake K, Chiu IM. Somatosensory and autonomic neuronal regulation of the immune response. Nat Rev Neurosci. 2022 03; 23(3):157-171. PMID: 34997214; PMCID: PMC9539447.
    Citations: 1     Fields:    Translation:HumansAnimals
  9. Wallrapp A, Yang D, Chiu IM. Enteric glial cells mediate gut immunity and repair. Trends Neurosci. 2022 04; 45(4):251-253. PMID: 34973845.
    Citations:    Fields:    Translation:HumansCells
  10. Clark LE, Clark SA, Lin C, Liu J, Coscia A, Nabel KG, Yang P, Neel DV, Lee H, Brusic V, Stryapunina I, Plante KS, Ahmed AA, Catteruccia F, Young-Pearse TL, Chiu IM, Llopis PM, Weaver SC, Abraham J. VLDLR and ApoER2 are receptors for multiple alphaviruses. Nature. 2022 02; 602(7897):475-480. PMID: 34929721; PMCID: PMC8808280.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  11. Yang NJ, Isensee J, Neel DV, Quadros AU, Zhang HB, Lauzadis J, Liu SM, Shiers S, Belu A, Palan S, Marlin S, Maignel J, Kennedy-Curran A, Tong VS, Moayeri M, Röderer P, Nitzsche A, Lu M, Pentelute BL, Brüstle O, Tripathi V, Foster KA, Price TJ, Collier RJ, Leppla SH, Puopolo M, Bean BP, Cunha TM, Hucho T, Chiu IM. Anthrax toxins regulate pain signaling and can deliver molecular cargoes into ANTXR2+ DRG sensory neurons. Nat Neurosci. 2022 02; 25(2):168-179. PMID: 34931070; PMCID: PMC9388775.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Yang NJ, Neel DV, Deng L, Heyang M, Kennedy-Curran A, Tong VS, Park JM, Chiu IM. Nociceptive Sensory Neurons Mediate Inflammation Induced by Bacillus Anthracis Edema Toxin. Front Immunol. 2021; 12:642373. PMID: 34413846; PMCID: PMC8369925.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Lin T, Quellier D, Lamb J, Voisin T, Baral P, Bock F, Schönberg A, Mirchev R, Pier G, Chiu I, Gadjeva M. Pseudomonas aeruginosa-induced nociceptor activation increases susceptibility to infection. PLoS Pathog. 2021 05; 17(5):e1009557. PMID: 33956874.
    Citations: 6     Fields:    Translation:AnimalsCells
  14. Deng L, Chiu IM. Microbes and pain. PLoS Pathog. 2021 04; 17(4):e1009398. PMID: 33793668.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  15. Voisin T, Perner C, Messou MA, Shiers S, Ualiyeva S, Kanaoka Y, Price TJ, Sokol CL, Bankova LG, Austen KF, Chiu IM. The CysLT2R receptor mediates leukotriene C4-driven acute and chronic itch. Proc Natl Acad Sci U S A. 2021 03 30; 118(13). PMID: 33753496.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  16. Yan Y, Ramanan D, Rozenberg M, McGovern K, Rastelli D, Vijaykumar B, Yaghi O, Voisin T, Mosaheb M, Chiu I, Itzkovitz S, Rao M, Mathis D, Benoist C. Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut. Immunity. 2021 03 09; 54(3):499-513.e5. PMID: 33691135; PMCID: PMC8133394.
    Citations: 18     Fields:    Translation:AnimalsCells
  17. Jacobson A, Yang D, Vella M, Chiu IM. The intestinal neuro-immune axis: crosstalk between neurons, immune cells, and microbes. Mucosal Immunol. 2021 05; 14(3):555-565. PMID: 33542493; PMCID: PMC8075967.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  18. Sanmarco LM, Wheeler MA, Gutiérrez-Vázquez C, Polonio CM, Linnerbauer M, Pinho-Ribeiro FA, Li Z, Giovannoni F, Batterman KV, Scalisi G, Zandee SEJ, Heck ES, Alsuwailm M, Rosene DL, Becher B, Chiu IM, Prat A, Quintana FJ. Gut-licensed IFN?+ NK cells drive LAMP1+TRAIL+ anti-inflammatory astrocytes. Nature. 2021 02; 590(7846):473-479. PMID: 33408417; PMCID: PMC8039910.
    Citations: 50     Fields:    Translation:HumansAnimalsCells
  19. Lagomarsino VN, Kostic AD, Chiu IM. Mechanisms of microbial-neuronal interactions in pain and nociception. Neurobiol Pain. 2021 Jan-Jul; 9:100056. PMID: 33392418.
    Citations: 7     
  20. Perner C, Flayer CH, Zhu X, Aderhold PA, Dewan ZNA, Voisin T, Camire RB, Chow OA, Chiu IM, Sokol CL. Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens. Immunity. 2020 11 17; 53(5):1063-1077.e7. PMID: 33098765.
    Citations: 38     Fields:    Translation:AnimalsCells
  21. Wu M, Chen Y, Xia H, Wang C, Tan CY, Cai X, Liu Y, Ji F, Xiong P, Liu R, Guan Y, Duan Y, Kuang D, Xu S, Cai H, Xia Q, Yang D, Wang MW, Chiu IM, Cheng C, Ahern PP, Liu L, Wang G, Surana NK, Xia T, Kasper DL. Transcriptional and proteomic insights into the host response in fatal COVID-19 cases. Proc Natl Acad Sci U S A. 2020 11 10; 117(45):28336-28343. PMID: 33082228; PMCID: PMC7668053.
    Citations: 51     Fields:    Translation:HumansCells
  22. Chiu I, Rolls A. Editorial overview: Brain, gut and immune system interactions. Curr Opin Neurobiol. 2020 06; 62:iii-v. PMID: 32507295.
    Citations: 1     Fields:    
  23. Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 03 17; 52(3):464-474. PMID: 32187517.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  24. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408. PMID: 32102913; PMCID: PMC7071852.
    Citations: 13     Fields:    Translation:AnimalsCells
  25. Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. PMID: 31969699; PMCID: PMC7184936.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  26. Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22. PMID: 31813624.
    Citations: 84     Fields:    Translation:AnimalsCells
  27. Pinho-Ribeiro FA, Chiu IM. Nociceptor nerves set the stage for skin immunity. Cell Res. 2019 11; 29(11):877-878. PMID: 31619764; PMCID: PMC6889511.
    Citations: 2     Fields:    Translation:Cells
  28. Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6. PMID: 31604686.
    Citations: 64     Fields:    Translation:AnimalsCells
  29. Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nat Rev Immunol. 2019 07; 19(7):433-447. PMID: 30874629; PMCID: PMC6700742.
    Citations: 94     Fields:    Translation:HumansAnimalsCells
  30. Blake KJ, Jiang XR, Chiu IM. Neuronal Regulation of Immunity in the Skin and Lungs. Trends Neurosci. 2019 08; 42(8):537-551. PMID: 31213389; PMCID: PMC6661013.
    Citations: 23     Fields:    Translation:HumansAnimals
  31. Voisin T, Chiu IM. Mast Cells Get on Your Nerves in Itch. Immunity. 2019 05 21; 50(5):1117-1119. PMID: 31117004.
    Citations: 2     Fields:    Translation:HumansCells
  32. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995; PMCID: PMC6531322.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  33. Voisin T, Chiu IM. Molecular link between itch and atopic dermatitis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12851-12853. PMID: 30538205; PMCID: PMC6304981.
    Citations: 3     Fields:    Translation:HumansCells
  34. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626. PMID: 30013196.
    Citations: 2     Fields:    
  35. Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 05 17; 173(5):1083-1097.e22. PMID: 29754819.
    Citations: 112     Fields:    Translation:HumansAnimalsCells
  36. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426. PMID: 29505031; PMCID: PMC6263165.
    Citations: 116     Fields:    Translation:AnimalsCells
  37. Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37. PMID: 29295977.
    Citations: 46     Fields:    Translation:AnimalsCells
  38. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 11 30; 551(7682):658. PMID: 29143821.
    Citations: 2     Fields:    
  39. Chavan SS, Ma P, Chiu IM. Neuro-immune interactions in inflammation and host defense: Implications for transplantation. Am J Transplant. 2018 03; 18(3):556-563. PMID: 28941325; PMCID: PMC5820210.
    Citations: 15     Fields:    Translation:HumansAnimals
  40. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356. PMID: 28902842; PMCID: PMC5746044.
    Citations: 232     Fields:    Translation:AnimalsCells
  41. Voisin T, Bouvier A, Chiu IM. Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol. 2017 06 01; 29(6):247-261. PMID: 28814067; PMCID: PMC5890890.
    Citations: 37     Fields:    Translation:HumansAnimals
  42. Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 03 09; 168(6):1135-1148.e12. PMID: 28262351.
    Citations: 79     Fields:    Translation:AnimalsCells
  43. Lai NY, Mills K, Chiu IM. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. J Intern Med. 2017 07; 282(1):5-23. PMID: 28155242; PMCID: PMC5474171.
    Citations: 39     Fields:    Translation:HumansCells
  44. Chiu IM. Infection, Pain, and Itch. Neurosci Bull. 2018 Feb; 34(1):109-119. PMID: 28144843.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  45. Yang NJ, Chiu IM. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol. 2017 03 10; 429(5):587-605. PMID: 28065740; PMCID: PMC5325782.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  46. Pinho-Ribeiro FA, Verri WA, Chiu IM. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends Immunol. 2017 Jan; 38(1):5-19. PMID: 27793571; PMCID: PMC5205568.
    Citations: 227     Fields:    Translation:HumansAnimalsCells
  47. Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? Cell Host Microbe. 2016 Jun 08; 19(6):755-9. PMID: 27281567.
    Citations: 16     Fields:    Translation:HumansCells
  48. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-1193. PMID: 27183444; PMCID: PMC4874496.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17. PMID: 26598697; PMCID: PMC4679057.
    Citations: 64     Fields:    Translation:AnimalsCells
  50. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026; PMCID: PMC4506220.
    Citations: 147     Fields:    Translation:AnimalsCells
  51. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 06; 4:e06720. PMID: 25658835.
    Citations: 4     Fields:    
  52. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3. PMID: 25525749.
    Citations: 103     Fields:    Translation:AnimalsCells
  53. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066; PMCID: PMC4429606.
    Citations: 88     Fields:    Translation:HumansAnimalsCells
  54. Zhao F, Heesters BA, Chiu I, Gao Y, Shi J, Zhou N, Carroll MC, Xu B. L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials. Org Biomol Chem. 2014 Sep 21; 12(35):6816-9. PMID: 25078446.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  55. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7. PMID: 23965627.
    Citations: 312     Fields:    Translation:AnimalsCells
  56. Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013 Jul 25; 4(2):385-401. PMID: 23850290.
    Citations: 303     Fields:    Translation:HumansAnimalsCells
  57. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7. PMID: 22837035.
    Citations: 205     Fields:    Translation:HumansCells
  58. Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res. 2010 Sep 01; 87(4):618-27. PMID: 20462867.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  59. Kim SS, Ye C, Kumar P, Chiu I, Subramanya S, Wu H, Shankar P, Manjunath N. Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Mol Ther. 2010 May; 18(5):993-1001. PMID: 20216529; PMCID: PMC2890121.
    Citations: 60     Fields:    Translation:AnimalsCells
  60. Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20960-5. PMID: 19933335.
    Citations: 89     Fields:    Translation:AnimalsCells
  61. Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8. PMID: 18997009; PMCID: PMC2581614.
    Citations: 166     Fields:    Translation:HumansAnimalsCells
  62. Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, Liu D. Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action. Biochem Biophys Res Commun. 2007 Jul 13; 358(4):1120-7. PMID: 17521609.
    Citations: 3     Fields:    Translation:HumansCells
  63. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15. PMID: 17060494; PMCID: PMC2064562.
    Citations: 120     Fields:    Translation:AnimalsCells
  64. Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12. PMID: 16942749.
    Citations: 17     Fields:    Translation:AnimalsCells
  65. Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23; 203(1):141-52. PMID: 16390934; PMCID: PMC2118091.
    Citations: 98     Fields:    Translation:Animals
  66. Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3886-91. PMID: 14999103; PMCID: PMC374339.
    Citations: 103     Fields:    Translation:AnimalsCells
  67. Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62. PMID: 14718661; PMCID: PMC321754.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  68. Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL. The human natural killer cell immune synapse. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):15062-7. PMID: 10611338; PMCID: PMC24773.
    Citations: 150     Fields:    Translation:HumansCells
  69. Chiu I, Davis DM, Strominger JL. Trafficking of spontaneously endocytosed MHC proteins. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13944-9. PMID: 10570178; PMCID: PMC24170.
    Citations: 13     Fields:    Translation:HumansCells
  70. Davis DM, Reyburn HT, Pazmany L, Chiu I, Mandelboim O, Strominger JL. Impaired spontaneous endocytosis of HLA-G. Eur J Immunol. 1997 Oct; 27(10):2714-9. PMID: 9368631.
    Citations: 16     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.