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Isaac Chiu, Ph.D.

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Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AT010774 (QUAVE, CASSANDRA LEAH) Sep 15, 2019 - Aug 31, 2021
    NIH/NCCIH
    Mechanistic studies on analgesic effects of terpene enriched extracts from hops
    Role: Co-Principal Investigator
  2. R01AI130019 (CHIU, ISAAC MING-CHENG) Sep 25, 2017 - Aug 31, 2022
    NIH/NIAID
    Pain and Neuro-immune Signaling in S. pyogenes pathogenesis
    Role: Principal Investigator
  3. DP2AT009499 (CHIU, ISAAC MING-CHENG) Sep 30, 2016 - Sep 29, 2021
    NIH/NCCIH
    Sensory Neuron-Bacteria Interactions in Modulating Pain and the Host Microbiota
    Role: Principal Investigator
  4. K22AI114810 (CHIU, ISAAC MING-CHENG) Apr 15, 2015 - Mar 31, 2017
    NIH/NIAID
    The role of nociceptor neurons in bacterial host defense and inflammation
    Role: Principal Investigator
  5. F32NS076297 (CHIU, ISAAC MING-CHENG) Aug 1, 2011 - Jul 31, 2013
    NIH/NINDS
    The Role of Direct Pathogen Detection by Sensory Neurons in Combating Bacterial I
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Chiu I, Rolls A. Editorial overview: Brain, gut and immune system interactions. Curr Opin Neurobiol. 2020 06; 62:iii-v. PMID: 32507295.
    Citations:    
  2. Chu C, Artis D, Chiu IM. Neuro-immune Interactions in the Tissues. Immunity. 2020 03 17; 52(3):464-474. PMID: 32187517.
    Citations:    
  3. Wang K, Yaghi OK, Spallanzani RG, Chen X, Zemmour D, Lai N, Chiu IM, Benoist C, Mathis D. Neuronal, stromal, and T-regulatory cell crosstalk in murine skeletal muscle. Proc Natl Acad Sci U S A. 2020 03 10; 117(10):5402-5408. PMID: 32102913.
    Citations:    
  4. Zhang B, Ma S, Rachmin I, He M, Baral P, Choi S, Gonçalves WA, Shwartz Y, Fast EM, Su Y, Zon LI, Regev A, Buenrostro JD, Cunha TM, Chiu IM, Fisher DE, Hsu YC. Hyperactivation of sympathetic nerves drives depletion of melanocyte stem cells. Nature. 2020 01; 577(7792):676-681. PMID: 31969699.
    Citations:    
  5. Lai NY, Musser MA, Pinho-Ribeiro FA, Baral P, Jacobson A, Ma P, Potts DE, Chen Z, Paik D, Soualhi S, Yan Y, Misra A, Goldstein K, Lagomarsino VN, Nordstrom A, Sivanathan KN, Wallrapp A, Kuchroo VK, Nowarski R, Starnbach MN, Shi H, Surana NK, An D, Wu C, Huh JR, Rao M, Chiu IM. Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. Cell. 2020 01 09; 180(1):33-49.e22. PMID: 31813624.
    Citations:    
  6. Pinho-Ribeiro FA, Chiu IM. Nociceptor nerves set the stage for skin immunity. Cell Res. 2019 11; 29(11):877-878. PMID: 31619764.
    Citations:    
  7. Wallrapp A, Burkett PR, Riesenfeld SJ, Kim SJ, Christian E, Abdulnour RE, Thakore PI, Schnell A, Lambden C, Herbst RH, Khan P, Tsujikawa K, Xavier RJ, Chiu IM, Levy BD, Regev A, Kuchroo VK. Calcitonin Gene-Related Peptide Negatively Regulates Alarmin-Driven Type 2 Innate Lymphoid Cell Responses. Immunity. 2019 10 15; 51(4):709-723.e6. PMID: 31604686.
    Citations:    
  8. Baral P, Udit S, Chiu IM. Pain and immunity: implications for host defence. Nat Rev Immunol. 2019 07; 19(7):433-447. PMID: 30874629.
    Citations:    
  9. Blake KJ, Jiang XR, Chiu IM. Neuronal Regulation of Immunity in the Skin and Lungs. Trends Neurosci. 2019 08; 42(8):537-551. PMID: 31213389.
    Citations:    
  10. Voisin T, Chiu IM. Mast Cells Get on Your Nerves in Itch. Immunity. 2019 05 21; 50(5):1117-1119. PMID: 31117004.
    Citations:    
  11. Leyva-Castillo JM, Galand C, Kam C, Burton O, Gurish M, Musser MA, Goldsmith JD, Hait E, Nurko S, Brombacher F, Dong C, Finkelman FD, Lee RT, Ziegler S, Chiu I, Austen KF, Geha RS. Mechanical Skin Injury Promotes Food Anaphylaxis by Driving Intestinal Mast Cell Expansion. Immunity. 2019 05 21; 50(5):1262-1275.e4. PMID: 31027995.
    Citations:    
  12. Voisin T, Chiu IM. Molecular link between itch and atopic dermatitis. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):12851-12853. PMID: 30538205.
    Citations:    Fields:    Translation:HumansCells
  13. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Author Correction: Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 Oct; 24(10):1625-1626. PMID: 30013196.
    Citations:    Fields:    
  14. Pinho-Ribeiro FA, Baddal B, Haarsma R, O'Seaghdha M, Yang NJ, Blake KJ, Portley M, Verri WA, Dale JB, Wessels MR, Chiu IM. Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 05 17; 173(5):1083-1097.e22. PMID: 29754819.
    Citations: 2     Fields:    
  15. Baral P, Umans BD, Li L, Wallrapp A, Bist M, Kirschbaum T, Wei Y, Zhou Y, Kuchroo VK, Burkett PR, Yipp BG, Liberles SD, Chiu IM. Nociceptor sensory neurons suppress neutrophil and ?d T cell responses in bacterial lung infections and lethal pneumonia. Nat Med. 2018 05; 24(4):417-426. PMID: 29505031.
    Citations: 3     Fields:    
  16. Blake KJ, Baral P, Voisin T, Lubkin A, Pinho-Ribeiro FA, Adams KL, Roberson DP, Ma YC, Otto M, Woolf CJ, Torres VJ, Chiu IM. Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314. Nat Commun. 2018 01 02; 9(1):37. PMID: 29295977.
    Citations:    Fields:    Translation:AnimalsCells
  17. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 11 30; 551(7682):658. PMID: 29143821.
    Citations:    Fields:    
  18. Chavan SS, Ma P, Chiu IM. Neuro-immune interactions in inflammation and host defense: Implications for transplantation. Am J Transplant. 2018 03; 18(3):556-563. PMID: 28941325.
    Citations: 1     Fields:    
  19. Wallrapp A, Riesenfeld SJ, Burkett PR, Abdulnour RE, Nyman J, Dionne D, Hofree M, Cuoco MS, Rodman C, Farouq D, Haas BJ, Tickle TL, Trombetta JJ, Baral P, Klose CSN, Mahlakõiv T, Artis D, Rozenblatt-Rosen O, Chiu IM, Levy BD, Kowalczyk MS, Regev A, Kuchroo VK. The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation. Nature. 2017 09 21; 549(7672):351-356. PMID: 28902842.
    Citations: 16     Fields:    Translation:AnimalsCells
  20. Voisin T, Bouvier A, Chiu IM. Neuro-immune interactions in allergic diseases: novel targets for therapeutics. Int Immunol. 2017 06 01; 29(6):247-261. PMID: 28814067.
    Citations: 2     Fields:    Translation:HumansAnimals
  21. Yissachar N, Zhou Y, Ung L, Lai NY, Mohan JF, Ehrlicher A, Weitz DA, Kasper DL, Chiu IM, Mathis D, Benoist C. An Intestinal Organ Culture System Uncovers a Role for the Nervous System in Microbe-Immune Crosstalk. Cell. 2017 03 09; 168(6):1135-1148.e12. PMID: 28262351.
    Citations: 17     Fields:    Translation:AnimalsCells
  22. Lai NY, Mills K, Chiu IM. Sensory neuron regulation of gastrointestinal inflammation and bacterial host defence. J Intern Med. 2017 07; 282(1):5-23. PMID: 28155242.
    Citations: 7     Fields:    Translation:HumansCells
  23. Chiu IM. Infection, Pain, and Itch. Neurosci Bull. 2018 Feb; 34(1):109-119. PMID: 28144843.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Yang NJ, Chiu IM. Bacterial Signaling to the Nervous System through Toxins and Metabolites. J Mol Biol. 2017 03 10; 429(5):587-605. PMID: 28065740.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  25. Pinho-Ribeiro FA, Verri WA, Chiu IM. Nociceptor Sensory Neuron-Immune Interactions in Pain and Inflammation. Trends Immunol. 2017 Jan; 38(1):5-19. PMID: 27793571.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  26. Baral P, Mills K, Pinho-Ribeiro FA, Chiu IM. Pain and Itch: Beneficial or Harmful to Antimicrobial Defense? Cell Host Microbe. 2016 Jun 08; 19(6):755-9. PMID: 27281567.
    Citations: 6     Fields:    Translation:HumansCells
  27. Chiu IM, Pinho-Ribeiro FA, Woolf CJ. Pain and infection: pathogen detection by nociceptors. Pain. 2016 06; 157(6):1192-3. PMID: 27183444.
    Citations:    Fields:    Translation:HumansAnimalsCells
  28. Ghasemlou N, Chiu IM, Julien JP, Woolf CJ. CD11b+Ly6G- myeloid cells mediate mechanical inflammatory pain hypersensitivity. Proc Natl Acad Sci U S A. 2015 Dec 08; 112(49):E6808-17. PMID: 26598697.
    Citations: 22     Fields:    Translation:AnimalsCells
  29. Talbot S, Abdulnour RE, Burkett PR, Lee S, Cronin SJ, Pascal MA, Laedermann C, Foster SL, Tran JV, Lai N, Chiu IM, Ghasemlou N, DiBiase M, Roberson D, Von Hehn C, Agac B, Haworth O, Seki H, Penninger JM, Kuchroo VK, Bean BP, Levy BD, Woolf CJ. Silencing Nociceptor Neurons Reduces Allergic Airway Inflammation. Neuron. 2015 Jul 15; 87(2):341-54. PMID: 26119026.
    Citations: 30     Fields:    Translation:AnimalsCells
  30. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman G, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf C. Correction: Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2015 Feb 06; 4:e06720. PMID: 25658835.
    Citations: 1     Fields:    
  31. Chiu IM, Barrett LB, Williams EK, Strochlic DE, Lee S, Weyer AD, Lou S, Bryman GS, Roberson DP, Ghasemlou N, Piccoli C, Ahat E, Wang V, Cobos EJ, Stucky CL, Ma Q, Liberles SD, Woolf CJ. Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity. Elife. 2014 Dec 19; 3. PMID: 25525749.
    Citations: 38     Fields:    Translation:AnimalsCells
  32. Wainger BJ, Buttermore ED, Oliveira JT, Mellin C, Lee S, Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L, Huebner EA, Bilgin C, Tsujimoto N, Brenneis C, Kapur K, Rubin LL, Eggan K, Woolf CJ. Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts. Nat Neurosci. 2015 Jan; 18(1):17-24. PMID: 25420066.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  33. Zhao F, Heesters BA, Chiu I, Gao Y, Shi J, Zhou N, Carroll MC, Xu B. L-Rhamnose-containing supramolecular nanofibrils as potential immunosuppressive materials. Org Biomol Chem. 2014 Sep 21; 12(35):6816-9. PMID: 25078446.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  34. Chiu IM, Heesters BA, Ghasemlou N, Von Hehn CA, Zhao F, Tran J, Wainger B, Strominger A, Muralidharan S, Horswill AR, Bubeck Wardenburg J, Hwang SW, Carroll MC, Woolf CJ. Bacteria activate sensory neurons that modulate pain and inflammation. Nature. 2013 Sep 05; 501(7465):52-7. PMID: 23965627.
    Citations: 110     Fields:    Translation:AnimalsCells
  35. Chiu IM, Morimoto ET, Goodarzi H, Liao JT, O'Keeffe S, Phatnani HP, Muratet M, Carroll MC, Levy S, Tavazoie S, Myers RM, Maniatis T. A neurodegeneration-specific gene-expression signature of acutely isolated microglia from an amyotrophic lateral sclerosis mouse model. Cell Rep. 2013 Jul 25; 4(2):385-401. PMID: 23850290.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  36. Chiu IM, von Hehn CA, Woolf CJ. Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology. Nat Neurosci. 2012 Jul 26; 15(8):1063-7. PMID: 22837035.
    Citations: 83     Fields:    Translation:HumansCells
  37. Haas MS, Alicot EM, Schuerpf F, Chiu I, Li J, Moore FD, Carroll MC. Blockade of self-reactive IgM significantly reduces injury in a murine model of acute myocardial infarction. Cardiovasc Res. 2010 Sep 01; 87(4):618-27. PMID: 20462867.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  38. Kim SS, Ye C, Kumar P, Chiu I, Subramanya S, Wu H, Shankar P, Manjunath N. Targeted delivery of siRNA to macrophages for anti-inflammatory treatment. Mol Ther. 2010 May; 18(5):993-1001. PMID: 20216529.
    Citations: 44     Fields:    Translation:AnimalsCells
  39. Chiu IM, Phatnani H, Kuligowski M, Tapia JC, Carrasco MA, Zhang M, Maniatis T, Carroll MC. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice. Proc Natl Acad Sci U S A. 2009 Dec 08; 106(49):20960-5. PMID: 19933335.
    Citations: 49     Fields:    Translation:AnimalsCells
  40. Chiu IM, Chen A, Zheng Y, Kosaras B, Tsiftsoglou SA, Vartanian TK, Brown RH, Carroll MC. T lymphocytes potentiate endogenous neuroprotective inflammation in a mouse model of ALS. Proc Natl Acad Sci U S A. 2008 Nov 18; 105(46):17913-8. PMID: 18997009.
    Citations: 123     Fields:    Translation:HumansAnimalsCells
  41. Zhang H, Qin G, Liang G, Li J, Chiu I, Barrington RA, Liu D. Suppression of complement regulatory protein C1 inhibitor in vascular endothelial activation by inhibiting vascular cell adhesion molecule-1 action. Biochem Biophys Res Commun. 2007 Jul 13; 358(4):1120-7. PMID: 17521609.
    Citations: 2     Fields:    Translation:HumansCells
  42. Ma Y, Li J, Chiu I, Wang Y, Sloane JA, Lü J, Kosaras B, Sidman RL, Volpe JJ, Vartanian T. Toll-like receptor 8 functions as a negative regulator of neurite outgrowth and inducer of neuronal apoptosis. J Cell Biol. 2006 Oct 23; 175(2):209-15. PMID: 17060494.
    Citations: 89     Fields:    Translation:AnimalsCells
  43. Fu J, Lin G, Wu Z, Ceng B, Wu Y, Liang G, Qin G, Li J, Chiu I, Liu D. Anti-apoptotic role for C1 inhibitor in ischemia/reperfusion-induced myocardial cell injury. Biochem Biophys Res Commun. 2006 Oct 20; 349(2):504-12. PMID: 16942749.
    Citations: 14     Fields:    Translation:AnimalsCells
  44. Zhang M, Alicot EM, Chiu I, Li J, Verna N, Vorup-Jensen T, Kessler B, Shimaoka M, Chan R, Friend D, Mahmood U, Weissleder R, Moore FD, Carroll MC. Identification of the target self-antigens in reperfusion injury. J Exp Med. 2006 Jan 23; 203(1):141-52. PMID: 16390934.
    Citations: 88     Fields:    Translation:Animals
  45. Zhang M, Austen WG, Chiu I, Alicot EM, Hung R, Ma M, Verna N, Xu M, Hechtman HB, Moore FD, Carroll MC. Identification of a specific self-reactive IgM antibody that initiates intestinal ischemia/reperfusion injury. Proc Natl Acad Sci U S A. 2004 Mar 16; 101(11):3886-91. PMID: 14999103.
    Citations: 88     Fields:    Translation:AnimalsCells
  46. Deng LW, Chiu I, Strominger JL. MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression. Proc Natl Acad Sci U S A. 2004 Jan 20; 101(3):757-62. PMID: 14718661.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  47. Davis DM, Chiu I, Fassett M, Cohen GB, Mandelboim O, Strominger JL. The human natural killer cell immune synapse. Proc Natl Acad Sci U S A. 1999 Dec 21; 96(26):15062-7. PMID: 10611338.
    Citations: 108     Fields:    Translation:HumansCells
  48. Chiu I, Davis DM, Strominger JL. Trafficking of spontaneously endocytosed MHC proteins. Proc Natl Acad Sci U S A. 1999 Nov 23; 96(24):13944-9. PMID: 10570178.
    Citations: 12     Fields:    Translation:HumansCells
  49. Davis DM, Reyburn HT, Pazmany L, Chiu I, Mandelboim O, Strominger JL. Impaired spontaneous endocytosis of HLA-G. Eur J Immunol. 1997 Oct; 27(10):2714-9. PMID: 9368631.
    Citations: 15     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.