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profileRamesh Neelamegam, Ph.D.

TitleInstructor in Radiology
InstitutionMassachusetts General Hospital
DepartmentRadiology
AddressMassachusetts General Hospital
Rm 2301
149 13th Street
Charlestown MA 02129
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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Collier TL, Yokell DL, Livni E, Rice PA, Celen S, Serdons K, Neelamegam R, Bormans G, Harris D, Walji A, Hostetler ED, Bennacef I, Vasdev N. cGMP production of the radiopharmaceutical [18 F]MK-6240 for PET imaging of human neurofibrillary tangles. J Labelled Comp Radiopharm. 2017 May 15; 60(5):263-269. PMID: 28185305.
    View in: PubMed
  2. Neelamegam R, Yokell DL, Rice PA, Furumoto S, Kudo Y, Okamura N, El Fakhri G. A report of the automated radiosynthesis of the tau positron emission tomography radiopharmaceutical, [18 F]-THK-5351. J Labelled Comp Radiopharm. 2017 Feb; 60(2):140-146. PMID: 27859483.
    View in: PubMed
  3. Strebl MG, Wang C, Schroeder FA, Placzek MS, Wey HY, Van de Bittner GC, Neelamegam R, Hooker JM. Development of a Fluorinated Class-I HDAC Radiotracer Reveals Key Chemical Determinants of Brain Penetrance. ACS Chem Neurosci. 2016 05 18; 7(5):528-33. PMID: 26675505.
    View in: PubMed
  4. Schroeder FA, Wang C, Van de Bittner GC, Neelamegam R, Takakura WR, Karunakaran A, Wey HY, Reis SA, Gale J, Zhang YL, Holson EB, Haggarty SJ, Hooker JM. PET imaging demonstrates histone deacetylase target engagement and clarifies brain penetrance of known and novel small molecule inhibitors in rat. ACS Chem Neurosci. 2014 Oct 15; 5(10):1055-62. PMID: 25188794; PMCID: PMC4198064.
  5. Ren H, Wey HY, Strebl M, Neelamegam R, Ritter T, Hooker JM. Synthesis and imaging validation of [¹8F]MDL100907 enabled by Ni-mediated fluorination. ACS Chem Neurosci. 2014 Jul 16; 5(7):611-5. PMID: 24845956; PMCID: PMC4102961.
  6. Huang X, Liu W, Ren H, Neelamegam R, Hooker JM, Groves JT. Late stage benzylic C-H fluorination with [¹8F]fluoride for PET imaging. J Am Chem Soc. 2014 May 14; 136(19):6842-5. PMID: 24766544.
    View in: PubMed
  7. Neelamegam R, Hellenbrand T, Schroeder FA, Wang C, Hooker JM. Imaging evaluation of 5HT2C agonists, [(11)C]WAY-163909 and [(11)C]vabicaserin, formed by Pictet-Spengler cyclization. J Med Chem. 2014 Feb 27; 57(4):1488-94. PMID: 24491146; PMCID: PMC3983360.
  8. Wang C, Eessalu TE, Barth VN, Mitch CH, Wagner FF, Hong Y, Neelamegam R, Schroeder FA, Holson EB, Haggarty SJ, Hooker JM. Design, synthesis, and evaluation of hydroxamic acid-based molecular probes for in vivo imaging of histone deacetylase (HDAC) in brain. Am J Nucl Med Mol Imaging. 2013; 4(1):29-38. PMID: 24380043; PMCID: PMC3867727.
  9. Wang C, Moseley CK, Carlin SM, Wilson CM, Neelamegam R, Hooker JM. Radiosynthesis and evaluation of [11C]EMPA as a potential PET tracer for orexin 2 receptors. Bioorg Med Chem Lett. 2013 Jun 01; 23(11):3389-92. PMID: 23601709; PMCID: PMC3664928.
  10. Granda ML, Carlin SM, Moseley CK, Neelamegam R, Mandeville JB, Hooker JM. Synthesis and evaluation of methylated arylazepine compounds for PET imaging of 5-HT(2c) receptors. ACS Chem Neurosci. 2013 Feb 20; 4(2):261-5. PMID: 23421677; PMCID: PMC3751540.
  11. Moseley CK, Carlin SM, Neelamegam R, Hooker JM. An efficient and practical radiosynthesis of [11C]temozolomide. Org Lett. 2012 Dec 07; 14(23):5872-5. PMID: 23151019; PMCID: PMC3979304.
  12. Neelamegam R, Ricq EL, Malvaez M, Patnaik D, Norton S, Carlin SM, Hill IT, Wood MA, Haggarty SJ, Hooker JM. Brain-penetrant LSD1 inhibitors can block memory consolidation. ACS Chem Neurosci. 2012 Feb 15; 3(2):120-128. PMID: 22754608.
    View in: PubMed
  13. Edwardraja S, Neelamegam R, Ramadoss V, Venkatesan S, Lee SG. Redesigning of anti-c-Met single chain Fv antibody for the cytoplasmic folding and its structural analysis. Biotechnol Bioeng. 2010 Jun 15; 106(3):367-75. PMID: 20178123.
    View in: PubMed
  14. Kim YJ, Neelamegam R, Heo MA, Edwardraja S, Paik HJ, Lee SG. Improving the productivity of single-chain Fv antibody against c-Met by rearranging the order of its variable domains. J Microbiol Biotechnol. 2008 Jun; 18(6):1186-90. PMID: 18600066.
    View in: PubMed
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