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Last Name
Institution

profileDan L Longo, M.D.

TitleProfessor of Medicine
InstitutionBrigham and Women's Hospital
DepartmentMedicine
AddressHarvard Medical School
Countway Lib/BWH/NEJM
10 Shattuck St
Boston MA 02115
Phone617/487-6573
Fax617/739-9864
vCardDownload vCard (login for email)

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
Z01AG000109     (LONGO, DAN L)
NIH/NIA
Cell Biology Of Lymphoma
Role: Principal Investigator

Z01AG000110     (LONGO, DAN L.)
NIH/NIA
Role Of Cadherins In Tumor Progression
Role: Principal Investigator

Z01AG000114     (LONGO, DAN L.)
NIH/NIA
Tumor-induced Immunosuppression
Role: Principal Investigator

Z01AG000115     (LONGO, DAN L.)
NIH/NIA
Rapamycin-sensitive pathway of T cell Activation
Role: Principal Investigator

Z01AG000116     (LONGO, DAN L.)
NIH/NIA
Regulation Of Mutant P53
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Pasquini L, Rossi Espagnet MC, Esposito G, De Vito R, Messina R, Gaspari S, Longo D. Langerhans' Cell Histiocytosis Mimicking a Pott Puffy Tumor. J Pediatr Hematol Oncol. 2017 May 29. PMID: 28562520.
    View in: PubMed
  2. Longo DL. Imatinib Changed Everything. N Engl J Med. 2017 03 09; 376(10):982-983. PMID: 28273011.
    View in: PubMed
  3. Laubach JP, Paba Prada CE, Richardson PG, Longo DL. Daratumumab, Elotuzumab, and the Development of Therapeutic Monoclonal Antibodies in Multiple Myeloma. Clin Pharmacol Ther. 2017 Jan; 101(1):81-88. PMID: 27806428.
    View in: PubMed
  4. Spriggs DR, Longo DL. PARP Inhibitors in Ovarian Cancer Treatment. N Engl J Med. 2016 12 01; 375(22):2197-2198. PMID: 27959768.
    View in: PubMed
  5. Mitchell SJ, Madrigal-Matute J, Scheibye-Knudsen M, Fang E, Aon M, González-Reyes JA, Cortassa S, Kaushik S, Gonzalez-Freire M, Patel B, Wahl D, Ali A, Calvo-Rubio M, Burón MI, Guiterrez V, Ward TM, Palacios HH, Cai H, Frederick DW, Hine C, Broeskamp F, Habering L, Dawson J, Beasley TM, Wan J, Ikeno Y, Hubbard G, Becker KG, Zhang Y, Bohr VA, Longo DL, Navas P, Ferrucci L, Sinclair DA, Cohen P, Egan JM, Mitchell JR, Baur JA, Allison DB, Anson RM, Villalba JM, Madeo F, Cuervo AM, Pearson KJ, Ingram DK, Bernier M, de Cabo R. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice. Cell Metab. 2016 Jun 14; 23(6):1093-112. PMID: 27304509; PMCID: PMC4911707 [Available on 06/14/17].
  6. Longo DL, Drazen JM. More on Data Sharing. N Engl J Med. 2016 May 12; 374(19):1896-7. PMID: 27168443.
    View in: PubMed
  7. Hesdorffer CS, Longo DL. Drug-Induced Megaloblastic Anemia. N Engl J Med. 2016 Feb 18; 374(7):696-7. PMID: 26886541.
    View in: PubMed
  8. Longo DL, Drazen JM. Data Sharing. N Engl J Med. 2016 Jan 21; 374(3):276-7. PMID: 26789876.
    View in: PubMed
  9. Radford J, Longo DL. Second Cancers after Treatment for Hodgkin's Lymphoma--Continuing Cause for Concern. N Engl J Med. 2015 Dec 24; 373(26):2572-3. PMID: 26699173.
    View in: PubMed
  10. Sasaki CY, Chen G, Munk R, Eitan E, Martindale J, Longo DL, Ghosh P. p(7°S6K¹) in the TORC1 pathway is essential for the differentiation of Th17 Cells, but not Th1, Th2, or Treg cells in mice. Eur J Immunol. 2016 Jan; 46(1):212-22. PMID: 26514620.
    View in: PubMed
  11. Dasgupta A, Chen KH, Munk RB, Sasaki CY, Curtis J, Longo DL, Ghosh P. Mechanism of Activation-Induced Downregulation of Mitofusin 2 in Human Peripheral Blood T Cells. J Immunol. 2015 Dec 15; 195(12):5780-6. PMID: 26566676; PMCID: PMC4670797 [Available on 12/15/16].
  12. Shanker A, Pellom ST, Dudimah DF, Thounaojam MC, de Kluyver RL, Brooks AD, Yagita H, McVicar DW, Murphy WJ, Longo DL, Sayers TJ. Bortezomib Improves Adoptive T-cell Therapy by Sensitizing Cancer Cells to FasL Cytotoxicity. Cancer Res. 2015 Dec 15; 75(24):5260-72. PMID: 26494122.
    View in: PubMed
  13. Hesdorffer CS, Longo DL. Drug-Induced Megaloblastic Anemia. N Engl J Med. 2015 Oct 22; 373(17):1649-58. PMID: 26488695.
    View in: PubMed
  14. Greene MF, Longo DL. Cautious Optimism for Offspring of Women with Cancer during Pregnancy. N Engl J Med. 2015 Nov 05; 373(19):1875-6. PMID: 26415086.
    View in: PubMed
  15. Singh H, Longo DL, Chabner BA. Improving Prospects for Targeting RAS. J Clin Oncol. 2015 Nov 01; 33(31):3650-9. PMID: 26371146.
    View in: PubMed
  16. Raje N, Longo DL. Monoclonal Antibodies in Multiple Myeloma Come of Age. N Engl J Med. 2015 Sep 24; 373(13):1264-6. PMID: 26308594.
    View in: PubMed
  17. Longo DL. Combined-Modality Therapy for Early-Stage Diffuse Large B-Cell Lymphoma: Knowing When to Quit. J Clin Oncol. 2015 Nov 10; 33(32):3684-5. PMID: 26282641.
    View in: PubMed
  18. Jameson JL, Longo DL. Precision medicine--personalized, problematic, and promising. N Engl J Med. 2015 Jun 04; 372(23):2229-34. PMID: 26014593.
    View in: PubMed
  19. Longo DL, Armitage JO. Controversies in the treatment of early-stage Hodgkin's lymphoma. N Engl J Med. 2015 Apr 23; 372(17):1667-9. PMID: 25901431.
    View in: PubMed
  20. Lin Y, Damjanovic A, Metter EJ, Nguyen H, Truong T, Najarro K, Morris C, Longo DL, Zhan M, Ferrucci L, Hodes RJ, Weng NP. Age-associated telomere attrition of lymphocytes in vivo is co-ordinated with changes in telomerase activity, composition of lymphocyte subsets and health conditions. Clin Sci (Lond). 2015 Mar; 128(6):367-77. PMID: 25317735.
    View in: PubMed
  21. Sznol M, Longo DL. Release the hounds! Activating the T-cell response to cancer. N Engl J Med. 2015 Jan 22; 372(4):374-5. PMID: 25482238.
    View in: PubMed
  22. Longo DL. Cancer-drug discovery--let's get ready for the next period. N Engl J Med. 2014 Dec 04; 371(23):2227-8. PMID: 25470699.
    View in: PubMed
  23. Maggio M, Snyder PJ, De Vita F, Ceda GP, Milaneschi Y, Lauretani F, Luci M, Cattabiani C, Peachey H, Valenti G, Cappola AR, Longo DL, Ferrucci L. Effects of transdermal testosterone treatment on inflammatory markers in elderly males. Endocr Pract. 2014 Nov; 20(11):1170-7. PMID: 25100359; PMCID: PMC5012420.
  24. Danoch H, Kalechman Y, Albeck M, Longo DL, Sredni B. Sensitizing B- and T- cell Lymphoma Cells to Paclitaxel/Abraxane-Induced Death by AS101 via Inhibition of the VLA-4-IL10-Survivin Axis. Mol Cancer Res. 2015 Mar; 13(3):411-22. PMID: 25351768.
    View in: PubMed
  25. Evans MK, Longo DL. PALB2 mutations and breast-cancer risk. N Engl J Med. 2014 Aug 07; 371(6):566-8. PMID: 25099582; PMCID: PMC4669041.
  26. Sharov AA, Nishiyama A, Qian Y, Dudekula DB, Longo DL, Schlessinger D, Ko MS. Chromatin properties of regulatory DNA probed by manipulation of transcription factors. J Comput Biol. 2014 Aug; 21(8):569-77. PMID: 24918633; PMCID: PMC4115781.
  27. Gainor JF, Longo DL, Chabner BA. Pharmacodynamic biomarkers: falling short of the mark? Clin Cancer Res. 2014 May 15; 20(10):2587-94. PMID: 24831281.
    View in: PubMed
  28. Layani-Bazar A, Skornick I, Berrebi A, Pauker MH, Noy E, Silberman A, Albeck M, Longo DL, Kalechman Y, Sredni B. Redox modulation of adjacent thiols in VLA-4 by AS101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state. Cancer Res. 2014 Jun 01; 74(11):3092-103. PMID: 24699624.
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  29. Tuchman SA, Shapiro GR, Ershler WB, Badros A, Cohen HJ, Dispenzieri A, Flores IQ, Kanapuru B, Jurivich D, Longo DL, Nourbakhsh A, Palumbo A, Walston J, Yates JW. Multiple myeloma in the very old: an IASIA conference report. J Natl Cancer Inst. 2014 Apr 03; 106(5). PMID: 24700806; PMCID: PMC4580557.
  30. Jimenez-Gomez Y, Mattison JA, Pearson KJ, Martin-Montalvo A, Palacios HH, Sossong AM, Ward TM, Younts CM, Lewis K, Allard JS, Longo DL, Belman JP, Malagon MM, Navas P, Sanghvi M, Moaddel R, Tilmont EM, Herbert RL, Morrell CH, Egan JM, Baur JA, Ferrucci L, Bogan JS, Bernier M, de Cabo R. Resveratrol improves adipose insulin signaling and reduces the inflammatory response in adipose tissue of rhesus monkeys on high-fat, high-sugar diet. Cell Metab. 2013 Oct 01; 18(4):533-45. PMID: 24093677; PMCID: PMC3832130.
  31. Bouchlaka MN, Sckisel GD, Chen M, Mirsoian A, Zamora AE, Maverakis E, Wilkins DE, Alderson KL, Hsiao HH, Weiss JM, Monjazeb AM, Hesdorffer C, Ferrucci L, Longo DL, Blazar BR, Wiltrout RH, Redelman D, Taub DD, Murphy WJ. Aging predisposes to acute inflammatory induced pathology after tumor immunotherapy. J Exp Med. 2013 Oct 21; 210(11):2223-37. PMID: 24081947; PMCID: PMC3804937.
  32. Chen KH, Dasgupta A, Ding J, Indig FE, Ghosh P, Longo DL. Role of mitofusin 2 (Mfn2) in controlling cellular proliferation. FASEB J. 2014 Jan; 28(1):382-94. PMID: 24081906; PMCID: PMC3868832.
  33. Longo DL. Reply to P. Borchmann et al. J Clin Oncol. 2013 Aug 20; 31(24):3046. PMID: 23943827.
    View in: PubMed
  34. Longo DL. Personalized cancer care is not new. Oncologist. 2013 Jun; 18(6):644-5. PMID: 23814158; PMCID: PMC4063384.
  35. Sutin AR, Zonderman AB, Uda M, Deiana B, Taub DD, Longo DL, Ferrucci L, Schlessinger D, Cucca F, Terracciano A. Personality traits and leptin. Psychosom Med. 2013 Jun; 75(5):505-9. PMID: 23697464; PMCID: PMC4511923.
  36. Longo DL. An interview with Dan L. Longo, Section Editor of the Malignant hematological diseases section. BMC Hematol. 2013 Apr 10; 13(1):2. PMID: 24499682; PMCID: PMC3816620.
  37. Smith TJ, Longo DL. Talking with patients about dying. N Engl J Med. 2013 Jan 31; 368(5):481. PMID: 23373069.
    View in: PubMed
  38. Gamaldo AA, Ferrucci L, Rifkind J, Longo DL, Zonderman AB. Relationship between mean corpuscular volume and cognitive performance in older adults. J Am Geriatr Soc. 2013 Jan; 61(1):84-9. PMID: 23301873; PMCID: PMC3555566.
  39. Nishiyama A, Sharov AA, Piao Y, Amano M, Amano T, Hoang HG, Binder BY, Tapnio R, Bassey U, Malinou JN, Correa-Cerro LS, Yu H, Xin L, Meyers E, Zalzman M, Nakatake Y, Stagg C, Sharova L, Qian Y, Dudekula D, Sheer S, Cadet JS, Hirata T, Yang HT, Goldberg I, Evans MK, Longo DL, Schlessinger D, Ko MS. Systematic repression of transcription factors reveals limited patterns of gene expression changes in ES cells. Sci Rep. 2013; 3:1390. PMID: 23462645; PMCID: PMC3589720.
  40. Longo DL. Covert operations: cancer's many subversive tactics in overcoming host defenses. Trans Am Clin Climatol Assoc. 2013; 124:163-73. PMID: 23874020; PMCID: PMC3715908.
  41. Longo DL. Treatment of advanced Hodgkin lymphoma: the more things change, the more they stay the same. J Clin Oncol. 2013 Feb 20; 31(6):660-2. PMID: 23182992.
    View in: PubMed
  42. Smith TJ, Longo DL. Talking with patients about dying. N Engl J Med. 2012 Oct 25; 367(17):1651-2. PMID: 23094729.
    View in: PubMed
  43. Mattison JA, Roth GS, Beasley TM, Tilmont EM, Handy AM, Herbert RL, Longo DL, Allison DB, Young JE, Bryant M, Barnard D, Ward WF, Qi W, Ingram DK, de Cabo R. Impact of caloric restriction on health and survival in rhesus monkeys from the NIA study. Nature. 2012 Sep 13; 489(7415):318-21. PMID: 22932268; PMCID: PMC3832985.
  44. Stewart SE, Yu D, Scharf JM, Neale BM, Fagerness JA, Mathews CA, Arnold PD, Evans PD, Gamazon ER, Davis LK, Osiecki L, McGrath L, Haddad S, Crane J, Hezel D, Illman C, Mayerfeld C, Konkashbaev A, Liu C, Pluzhnikov A, Tikhomirov A, Edlund CK, Rauch SL, Moessner R, Falkai P, Maier W, Ruhrmann S, Grabe HJ, Lennertz L, Wagner M, Bellodi L, Cavallini MC, Richter MA, Cook EH, Kennedy JL, Rosenberg D, Stein DJ, Hemmings SM, Lochner C, Azzam A, Chavira DA, Fournier E, Garrido H, Sheppard B, Umaña P, Murphy DL, Wendland JR, Veenstra-VanderWeele J, Denys D, Blom R, Deforce D, Van Nieuwerburgh F, Westenberg HG, Walitza S, Egberts K, Renner T, Miguel EC, Cappi C, Hounie AG, Conceição do Rosário M, Sampaio AS, Vallada H, Nicolini H, Lanzagorta N, Camarena B, Delorme R, Leboyer M, Pato CN, Pato MT, Voyiaziakis E, Heutink P, Cath DC, Posthuma D, Smit JH, Samuels J, Bienvenu OJ, Cullen B, Fyer AJ, Grados MA, Greenberg BD, McCracken JT, Riddle MA, Wang Y, Coric V, Leckman JF, Bloch M, Pittenger C, Eapen V, Black DW, Ophoff RA, Strengman E, Cusi D, Turiel M, Frau F, Macciardi F, Gibbs JR, Cookson MR, Singleton A, Hardy J, Crenshaw AT, Parkin MA, Mirel DB, Conti DV, Purcell S, Nestadt G, Hanna GL, Jenike MA, Knowles JA, Cox N, Pauls DL. Genome-wide association study of obsessive-compulsive disorder. Mol Psychiatry. 2013 Jul; 18(7):788-98. PMID: 22889921; PMCID: PMC4218751.
  45. Chen G, Ghosh P, O'Farrell T, Munk R, Rezanka LJ, Sasaki CY, Longo DL. Transforming growth factor ß1 (TGF-ß1) suppresses growth of B-cell lymphoma cells by p14(ARF)-dependent regulation of mutant p53. J Biol Chem. 2012 Jun 29; 287(27):23184-95. PMID: 22621932; PMCID: PMC3391099.
  46. Gottesman RF, Sojkova J, Beason-Held LL, An Y, Longo DL, Ferrucci L, Resnick SM. Patterns of regional cerebral blood flow associated with low hemoglobin in the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci. 2012 Sep; 67(9):963-9. PMID: 22552368; PMCID: PMC3436086.
  47. Longo DL. Tumor heterogeneity and personalized medicine. N Engl J Med. 2012 Mar 08; 366(10):956-7. PMID: 22397658.
    View in: PubMed
  48. Naitza S, Porcu E, Steri M, Taub DD, Mulas A, Xiao X, Strait J, Dei M, Lai S, Busonero F, Maschio A, Usala G, Zoledziewska M, Sidore C, Zara I, Pitzalis M, Loi A, Virdis F, Piras R, Deidda F, Whalen MB, Crisponi L, Concas A, Podda C, Uzzau S, Scheet P, Longo DL, Lakatta E, Abecasis GR, Cao A, Schlessinger D, Uda M, Sanna S, Cucca F. A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation. PLoS Genet. 2012 Jan; 8(1):e1002480. PMID: 22291609; PMCID: PMC3266885.
  49. Biragyn A, Longo DL. Neoplastic "Black Ops": cancer's subversive tactics in overcoming host defenses. Semin Cancer Biol. 2012 Feb; 22(1):50-9. PMID: 22257681; PMCID: PMC3288709.
  50. Jacobson CA, Longo DL. Follicular lymphoma: to treat or not to treat is no longer the question. J Natl Cancer Inst. 2012 Jan 04; 104(1):3-5. PMID: 22190632.
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  51. Hesdorffer CS, Malchinkhuu E, Biragyn A, Mabrouk OS, Kennedy RT, Madara K, Taub DD, Longo DL, Schwartz JB, Ferrucci L, Goetzl EJ. Distinctive immunoregulatory effects of adenosine on T cells of older humans. FASEB J. 2012 Mar; 26(3):1301-10. PMID: 22121051; PMCID: PMC3289505.
  52. Correa-Cerro LS, Piao Y, Sharov AA, Nishiyama A, Cadet JS, Yu H, Sharova LV, Xin L, Hoang HG, Thomas M, Qian Y, Dudekula DB, Meyers E, Binder BY, Mowrer G, Bassey U, Longo DL, Schlessinger D, Ko MS. Generation of mouse ES cell lines engineered for the forced induction of transcription factors. Sci Rep. 2011; 1:167. PMID: 22355682; PMCID: PMC3240988.
  53. Munk R, Ghosh P, Ghosh MC, Saito T, Xu M, Carter A, Indig F, Taub DD, Longo DL. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS One. 2011; 6(9):e24667. PMID: 21931802; PMCID: PMC3171460.
  54. Long JM, Lee GD, Kelley-Bell B, Spangler EL, Perez EJ, Longo DL, de Cabo R, Zou S, Rapp PR. Preserved learning and memory following 5-fluorouracil and cyclophosphamide treatment in rats. Pharmacol Biochem Behav. 2011 Nov; 100(1):205-11. PMID: 21875615; PMCID: PMC3183356.
  55. Urba WJ, Longo DL. Redirecting T cells. N Engl J Med. 2011 Aug 25; 365(8):754-7. PMID: 21830939.
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  56. Okada Y, Hirota T, Kamatani Y, Takahashi A, Ohmiya H, Kumasaka N, Higasa K, Yamaguchi-Kabata Y, Hosono N, Nalls MA, Chen MH, van Rooij FJ, Smith AV, Tanaka T, Couper DJ, Zakai NA, Ferrucci L, Longo DL, Hernandez DG, Witteman JC, Harris TB, O'Donnell CJ, Ganesh SK, Matsuda K, Tsunoda T, Tanaka T, Kubo M, Nakamura Y, Tamari M, Yamamoto K, Kamatani N. Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. PLoS Genet. 2011 Jun; 7(6):e1002067. PMID: 21738478; PMCID: PMC3128095.
  57. Nalls MA, Couper DJ, Tanaka T, van Rooij FJ, Chen MH, Smith AV, Toniolo D, Zakai NA, Yang Q, Greinacher A, Wood AR, Garcia M, Gasparini P, Liu Y, Lumley T, Folsom AR, Reiner AP, Gieger C, Lagou V, Felix JF, Völzke H, Gouskova NA, Biffi A, Döring A, Völker U, Chong S, Wiggins KL, Rendon A, Dehghan A, Moore M, Taylor K, Wilson JG, Lettre G, Hofman A, Bis JC, Pirastu N, Fox CS, Meisinger C, Sambrook J, Arepalli S, Nauck M, Prokisch H, Stephens J, Glazer NL, Cupples LA, Okada Y, Takahashi A, Kamatani Y, Matsuda K, Tsunoda T, Tanaka T, Kubo M, Nakamura Y, Yamamoto K, Kamatani N, Stumvoll M, Tönjes A, Prokopenko I, Illig T, Patel KV, Garner SF, Kuhnel B, Mangino M, Oostra BA, Thein SL, Coresh J, Wichmann HE, Menzel S, Lin J, Pistis G, Uitterlinden AG, Spector TD, Teumer A, Eiriksdottir G, Gudnason V, Bandinelli S, Frayling TM, Chakravarti A, van Duijn CM, Melzer D, Ouwehand WH, Levy D, Boerwinkle E, Singleton AB, Hernandez DG, Longo DL, Soranzo N, Witteman JC, Psaty BM, Ferrucci L, Harris TB, O'Donnell CJ, Ganesh SK. Multiple loci are associated with white blood cell phenotypes. PLoS Genet. 2011 Jun; 7(6):e1002113. PMID: 21738480; PMCID: PMC3128114.
  58. Najjar SS, Rao SV, Melloni C, Raman SV, Povsic TJ, Melton L, Barsness GW, Prather K, Heitner JF, Kilaru R, Gruberg L, Hasselblad V, Greenbaum AB, Patel M, Kim RJ, Talan M, Ferrucci L, Longo DL, Lakatta EG, Harrington RA. Intravenous erythropoietin in patients with ST-segment elevation myocardial infarction: REVEAL: a randomized controlled trial. JAMA. 2011 May 11; 305(18):1863-72. PMID: 21558517; PMCID: PMC3486644.
  59. Munk RB, Sugiyama K, Ghosh P, Sasaki CY, Rezanka L, Banerjee K, Takahashi H, Sen R, Longo DL. Antigen-independent IFN-? production by human naïve CD4 T cells activated by IL-12 plus IL-18. PLoS One. 2011 May 10; 6(5):e18553. PMID: 21572994; PMCID: PMC3091853.
  60. Longo D, Paonessa A, Specchio N, Delfino LN, Claps D, Fusco L, Randisi F, Genovese E, Vigevano F, Fariello G. Parry-Romberg syndrome and Rasmussen encephalitis: possible association. Clinical and neuroimaging features. J Neuroimaging. 2011 Apr; 21(2):188-93. PMID: 19555404.
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  61. Dixit VD, Yang H, Sayeed KS, Stote KS, Rumpler WV, Baer DJ, Longo DL, Mattson MP, Taub DD. Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production. J Inflamm (Lond). 2011 Mar 07; 8:6. PMID: 21385360; PMCID: PMC3058015.
  62. Hernandez DG, Nalls MA, Gibbs JR, Arepalli S, van der Brug M, Chong S, Moore M, Longo DL, Cookson MR, Traynor BJ, Singleton AB. Distinct DNA methylation changes highly correlated with chronological age in the human brain. Hum Mol Genet. 2011 Mar 15; 20(6):1164-72. PMID: 21216877; PMCID: PMC3043665.
  63. Pichler I, Minelli C, Sanna S, Tanaka T, Schwienbacher C, Naitza S, Porcu E, Pattaro C, Busonero F, Zanon A, Maschio A, Melville SA, Grazia Piras M, Longo DL, Guralnik J, Hernandez D, Bandinelli S, Aigner E, Murphy AT, Wroblewski V, Marroni F, Theurl I, Gnewuch C, Schadt E, Mitterer M, Schlessinger D, Ferrucci L, Witcher DR, Hicks AA, Weiss G, Uda M, Pramstaller PP. Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels. Hum Mol Genet. 2011 Mar 15; 20(6):1232-40. PMID: 21208937; PMCID: PMC3043660.
  64. Huang MC, Greig NH, Luo W, Tweedie D, Schwartz JB, Longo DL, Ferrucci L, Ershler WB, Goetzl EJ. Preferential enhancement of older human T cell cytokine generation, chemotaxis, proliferation and survival by lenalidomide. Clin Immunol. 2011 Feb; 138(2):201-11. PMID: 21130040; PMCID: PMC4642720.
  65. Chen G, Ghosh P, Longo DL. Distinctive mechanism for sustained TGF-ß signaling and growth inhibition: MEK1 activation-dependent stabilization of type II TGF-ß receptors. Mol Cancer Res. 2011 Jan; 9(1):78-89. PMID: 21131601; PMCID: PMC3076720.
  66. Brant LJ, Ferrucci L, Sheng SL, Concin H, Zonderman AB, Kelleher CC, Longo DL, Ulmer H, Strasak AM. Gender differences in the accuracy of time-dependent blood pressure indices for predicting coronary heart disease: A random-effects modeling approach. Gend Med. 2010 Dec; 7(6):616-27. PMID: 21195361; PMCID: PMC3023955.
  67. Reiter DA, Roque RA, Lin PC, Irrechukwu O, Doty S, Longo DL, Pleshko N, Spencer RG. Mapping proteoglycan-bound water in cartilage: Improved specificity of matrix assessment using multiexponential transverse relaxation analysis. Magn Reson Med. 2011 Feb; 65(2):377-84. PMID: 21264931; PMCID: PMC3350808.
  68. Melloni C, Rao SV, Povsic TJ, Melton L, Kim RJ, Kilaru R, Patel MR, Talan M, Ferrucci L, Longo DL, Lakatta EG, Najjar SS, Harrington RA. Design and rationale of the Reduction of Infarct Expansion and Ventricular Remodeling with Erythropoietin after Large Myocardial Infarction (REVEAL) trial. Am Heart J. 2010 Nov; 160(5):795-803.e2. PMID: 21095264; PMCID: PMC3018783.
  69. Alley DE, Metter EJ, Griswold ME, Harris TB, Simonsick EM, Longo DL, Ferrucci L. Changes in weight at the end of life: characterizing weight loss by time to death in a cohort study of older men. Am J Epidemiol. 2010 Sep 01; 172(5):558-65. PMID: 20682520; PMCID: PMC3025636.
  70. Longo DL. New therapies for castration-resistant prostate cancer. N Engl J Med. 2010 Jul 29; 363(5):479-81. PMID: 20818868.
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  71. Taub DD, Murphy WJ, Longo DL. Rejuvenation of the aging thymus: growth hormone-mediated and ghrelin-mediated signaling pathways. Curr Opin Pharmacol. 2010 Aug; 10(4):408-24. PMID: 20595009; PMCID: PMC2914845.
  72. Gibbs JR, van der Brug MP, Hernandez DG, Traynor BJ, Nalls MA, Lai SL, Arepalli S, Dillman A, Rafferty IP, Troncoso J, Johnson R, Zielke HR, Ferrucci L, Longo DL, Cookson MR, Singleton AB. Abundant quantitative trait loci exist for DNA methylation and gene expression in human brain. PLoS Genet. 2010 May 13; 6(5):e1000952. PMID: 20485568; PMCID: PMC2869317.
  73. Goetzl EJ, Huang MC, Kon J, Patel K, Schwartz JB, Fast K, Ferrucci L, Madara K, Taub DD, Longo DL. Gender specificity of altered human immune cytokine profiles in aging. FASEB J. 2010 Sep; 24(9):3580-9. PMID: 20453111; PMCID: PMC2923363.
  74. Tita-Nwa F, Bos A, Adjei A, Ershler WB, Longo DL, Ferrucci L. Correlates of D-dimer in older persons. Aging Clin Exp Res. 2010 Feb; 22(1):20-3. PMID: 20305364; PMCID: PMC2863304.
  75. Ferrucci L, Semba RD, Guralnik JM, Ershler WB, Bandinelli S, Patel KV, Sun K, Woodman RC, Andrews NC, Cotter RJ, Ganz T, Nemeth E, Longo DL. Proinflammatory state, hepcidin, and anemia in older persons. Blood. 2010 May 06; 115(18):3810-6. PMID: 20081092; PMCID: PMC2865871.
  76. Saito T, Sasaki CY, Rezanka LJ, Ghosh P, Longo DL. p52-Independent nuclear translocation of RelB promotes LPS-induced attachment. Biochem Biophys Res Commun. 2010 Jan 01; 391(1):235-41. PMID: 19903458; PMCID: PMC2812576.
  77. Patel KV, Semba RD, Ferrucci L, Newman AB, Fried LP, Wallace RB, Bandinelli S, Phillips CS, Yu B, Connelly S, Shlipak MG, Chaves PH, Launer LJ, Ershler WB, Harris TB, Longo DL, Guralnik JM. Red cell distribution width and mortality in older adults: a meta-analysis. J Gerontol A Biol Sci Med Sci. 2010 Mar; 65(3):258-65. PMID: 19880817; PMCID: PMC2822283.
  78. Tanaka T, Roy CN, Yao W, Matteini A, Semba RD, Arking D, Walston JD, Fried LP, Singleton A, Guralnik J, Abecasis GR, Bandinelli S, Longo DL, Ferrucci L. A genome-wide association analysis of serum iron concentrations. Blood. 2010 Jan 07; 115(1):94-6. PMID: 19880490; PMCID: PMC2803694.
  79. Nishiyama A, Xin L, Sharov AA, Thomas M, Mowrer G, Meyers E, Piao Y, Mehta S, Yee S, Nakatake Y, Stagg C, Sharova L, Correa-Cerro LS, Bassey U, Hoang H, Kim E, Tapnio R, Qian Y, Dudekula D, Zalzman M, Li M, Falco G, Yang HT, Lee SL, Monti M, Stanghellini I, Islam MN, Nagaraja R, Goldberg I, Wang W, Longo DL, Schlessinger D, Ko MS. Uncovering early response of gene regulatory networks in ESCs by systematic induction of transcription factors. Cell Stem Cell. 2009 Oct 02; 5(4):420-33. PMID: 19796622; PMCID: PMC2770715.
  80. Pierorazio PM, Ferrucci L, Kettermann A, Longo DL, Metter EJ, Carter HB. Serum testosterone is associated with aggressive prostate cancer in older men: results from the Baltimore Longitudinal Study of Aging. BJU Int. 2010 Mar; 105(6):824-9. PMID: 19751256; PMCID: PMC2848292.
  81. Longo DL. Late effects from radiation therapy: the hits just keep on coming. J Natl Cancer Inst. 2009 Jul 01; 101(13):904-5. PMID: 19535779.
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  82. Patel KV, Ferrucci L, Ershler WB, Longo DL, Guralnik JM. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch Intern Med. 2009 Mar 09; 169(5):515-23. PMID: 19273783; PMCID: PMC2765040.
  83. Patel KV, Longo DL, Ershler WB, Yu B, Semba RD, Ferrucci L, Guralnik JM. Haemoglobin concentration and the risk of death in older adults: differences by race/ethnicity in the NHANES III follow-up. Br J Haematol. 2009 May; 145(4):514-23. PMID: 19344387; PMCID: PMC2747286.
  84. Seam P, Janik JE, Longo DL, Devita VT. Role of chemotherapy in Hodgkin's lymphoma. Cancer J. 2009 Mar-Apr; 15(2):150-4. PMID: 19390311; PMCID: PMC2847426.
  85. Dissanayake SK, Olkhanud PB, O'Connell MP, Carter A, French AD, Camilli TC, Emeche CD, Hewitt KJ, Rosenthal DT, Leotlela PD, Wade MS, Yang SW, Brant L, Nickoloff BJ, Messina JL, Biragyn A, Hoek KS, Taub DD, Longo DL, Sondak VK, Hewitt SM, Weeraratna AT. Wnt5A regulates expression of tumor-associated antigens in melanoma via changes in signal transducers and activators of transcription 3 phosphorylation. Cancer Res. 2008 Dec 15; 68(24):10205-14. PMID: 19074888; PMCID: PMC2605679.
  86. Taub DD, Ershler WB, Janowski M, Artz A, Key ML, McKelvey J, Muller D, Moss B, Ferrucci L, Duffey PL, Longo DL. Immunity from smallpox vaccine persists for decades: a longitudinal study. Am J Med. 2008 Dec; 121(12):1058-64. PMID: 19028201; PMCID: PMC2610468.
  87. Fedorova OV, Simbirtsev AS, Kolodkin NI, Kotov AY, Agalakova NI, Kashkin VA, Tapilskaya NI, Bzhelyansky A, Reznik VA, Frolova EV, Nikitina ER, Budny GV, Longo DL, Lakatta EG, Bagrov AY. Monoclonal antibody to an endogenous bufadienolide, marinobufagenin, reverses preeclampsia-induced Na/K-ATPase inhibition and lowers blood pressure in NaCl-sensitive hypertension. J Hypertens. 2008 Dec; 26(12):2414-25. PMID: 19008721; PMCID: PMC2583455.
  88. Semba RD, Patel KV, Sun K, Guralnik JM, Ershler WB, Longo DL, Ferrucci L. Association between serum carboxymethyl-lysine, a dominant advanced glycation end product, and anemia in adults: the Baltimore longitudinal study of aging. J Am Geriatr Soc. 2008 Nov; 56(11):2145-7. PMID: 19016950; PMCID: PMC2603132.
  89. Ruggiero C, Metter EJ, Melenovsky V, Cherubini A, Najjar SS, Ble A, Senin U, Longo DL, Ferrucci L. High basal metabolic rate is a risk factor for mortality: the Baltimore Longitudinal Study of Aging. J Gerontol A Biol Sci Med Sci. 2008 Jul; 63(7):698-706. PMID: 18693224; PMCID: PMC4984846.
  90. Sharov AA, Falco G, Piao Y, Poosala S, Becker KG, Zonderman AB, Longo DL, Schlessinger D, Ko MSh. Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary. BMC Biol. 2008 Jun 03; 6:24. PMID: 18522719; PMCID: PMC2426674.
  91. Ershler WB, Ferrucci L, Longo DL. Hutchinson-Gilford progeria syndrome. N Engl J Med. 2008 May 29; 358(22):2409-10; author reply 2410-1. PMID: 18509130; PMCID: PMC4589223.
  92. Anderson DE, Fedorova OV, Morrell CH, Longo DL, Kashkin VA, Metzler JD, Bagrov AY, Lakatta EG. Endogenous sodium pump inhibitors and age-associated increases in salt sensitivity of blood pressure in normotensives. Am J Physiol Regul Integr Comp Physiol. 2008 Apr; 294(4):R1248-54. PMID: 18287222; PMCID: PMC2430746.
  93. Pearson KJ, Lewis KN, Price NL, Chang JW, Perez E, Cascajo MV, Tamashiro KL, Poosala S, Csiszar A, Ungvari Z, Kensler TW, Yamamoto M, Egan JM, Longo DL, Ingram DK, Navas P, de Cabo R. Nrf2 mediates cancer protection but not prolongevity induced by caloric restriction. Proc Natl Acad Sci U S A. 2008 Feb 19; 105(7):2325-30. PMID: 18287083; PMCID: PMC2268135.
  94. Kaneda A, Wang CJ, Cheong R, Timp W, Onyango P, Wen B, Iacobuzio-Donahue CA, Ohlsson R, Andraos R, Pearson MA, Sharov AA, Longo DL, Ko MS, Levchenko A, Feinberg AP. Enhanced sensitivity to IGF-II signaling links loss of imprinting of IGF2 to increased cell proliferation and tumor risk. Proc Natl Acad Sci U S A. 2007 Dec 26; 104(52):20926-31. PMID: 18087038; PMCID: PMC2409243.
  95. Sasaki CY, Slemenda CF, Ghosh P, Barberi TJ, Longo DL. Traf1 induction and protection from tumor necrosis factor by nuclear factor-kappaB p65 is independent of serine 536 phosphorylation. Cancer Res. 2007 Dec 01; 67(23):11218-25. PMID: 18056447; PMCID: PMC2408918.
  96. Carlson O, Martin B, Stote KS, Golden E, Maudsley S, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Rumpler WV, Baer DJ, Egan J, Mattson MP. Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women. Metabolism. 2007 Dec; 56(12):1729-34. PMID: 17998028; PMCID: PMC2121099.
  97. Heltemes-Harris LM, Gearhart PJ, Ghosh P, Longo DL. Activation-induced deaminase-mediated class switch recombination is blocked by anti-IgM signaling in a phosphatidylinositol 3-kinase-dependent fashion. Mol Immunol. 2008 Mar; 45(6):1799-806. PMID: 17983655; PMCID: PMC2274886.
  98. Hayun M, Okun E, Hayun R, Gafter U, Albeck M, Longo DL, Sredni B. Synergistic effect of AS101 and Bryostatin-1 on myeloid leukemia cell differentiation in vitro and in an animal model. Leukemia. 2007 Jul; 21(7):1504-13. PMID: 17508000.
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  99. Lustig A, Weeraratna AT, Wood WW, Teichberg D, Bertak D, Carter A, Poosala S, Firman J, Becker KG, Zonderman AB, Longo DL, Taub DD. Transcriptome analysis of age-, gender- and diet-associated changes in murine thymus. Cell Immunol. 2007 Jan; 245(1):42-61. PMID: 17499630; PMCID: PMC2271048.
  100. Stote KS, Baer DJ, Spears K, Paul DR, Harris GK, Rumpler WV, Strycula P, Najjar SS, Ferrucci L, Ingram DK, Longo DL, Mattson MP. A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults. Am J Clin Nutr. 2007 Apr; 85(4):981-8. PMID: 17413096; PMCID: PMC2645638.
  101. Chen G, Ghosh P, Osawa H, Sasaki CY, Rezanka L, Yang J, O'Farrell TJ, Longo DL. Resistance to TGF-beta 1 correlates with aberrant expression of TGF-beta receptor II in human B-cell lymphoma cell lines. Blood. 2007 Jun 15; 109(12):5301-7. PMID: 17339425; PMCID: PMC1890833.
  102. Ferrucci L, Guralnik JM, Bandinelli S, Semba RD, Lauretani F, Corsi A, Ruggiero C, Ershler WB, Longo DL. Unexplained anaemia in older persons is characterised by low erythropoietin and low levels of pro-inflammatory markers. Br J Haematol. 2007 Mar; 136(6):849-55. PMID: 17341272; PMCID: PMC2669300.
  103. Xu X, Zhan M, Duan W, Prabhu V, Brenneman R, Wood W, Firman J, Li H, Zhang P, Ibe C, Zonderman AB, Longo DL, Poosala S, Becker KG, Mattson MP. Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender. Genome Biol. 2007; 8(11):R234. PMID: 17988385; PMCID: PMC2258177.
  104. Zou S, Sinclair J, Wilson MA, Carey JR, Liedo P, Oropeza A, Kalra A, de Cabo R, Ingram DK, Longo DL, Wolkow CA. Comparative approaches to facilitate the discovery of prolongevity interventions: effects of tocopherols on lifespan of three invertebrate species. Mech Ageing Dev. 2007 Feb; 128(2):222-6. PMID: 17169403; PMCID: PMC1820625.
  105. Longo DL. Idiotype vaccination in follicular lymphoma: knocking on the doorway to cure. J Natl Cancer Inst. 2006 Sep 20; 98(18):1263-5. PMID: 16985240.
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  106. Ferrucci L, Maggio M, Bandinelli S, Basaria S, Lauretani F, Ble A, Valenti G, Ershler WB, Guralnik JM, Longo DL. Low testosterone levels and the risk of anemia in older men and women. Arch Intern Med. 2006 Jul 10; 166(13):1380-8. PMID: 16832003; PMCID: PMC2645631.
  107. Ershler WB, Longo DL. A report card for geriatric oncology: borderline pass, improvement needed. J Gerontol A Biol Sci Med Sci. 2006 Jul; 61(7):688. PMID: 16870629.
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  108. Maggio M, Guralnik JM, Longo DL, Ferrucci L. Interleukin-6 in aging and chronic disease: a magnificent pathway. J Gerontol A Biol Sci Med Sci. 2006 Jun; 61(6):575-84. PMID: 16799139; PMCID: PMC2645627.
  109. McHutchison JG, Manns MP, Longo DL. Definition and management of anemia in patients infected with hepatitis C virus. Liver Int. 2006 May; 26(4):389-98. PMID: 16629641.
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  110. Rezanka LJ, Kenny JJ, Longo DL. Dual isotype expressing B cells [kappa(+)/lambda(+)] arise during the ontogeny of B cells in the bone marrow of normal nontransgenic mice. Cell Immunol. 2005 Nov; 238(1):38-48. PMID: 16458869.
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  111. Lee GD, Longo DL, Wang Y, Rifkind JM, Abdul-Raman L, Mamczarz JA, Duffy KB, Spangler EL, Taub DD, Mattson MP, Ingram DK. Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy. Clin Cancer Res. 2006 Jan 01; 12(1):198-205. PMID: 16397043.
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  112. Ferrucci L, Guralnik JM, Woodman RC, Bandinelli S, Lauretani F, Corsi AM, Chaves PH, Ershler WB, Longo DL. Proinflammatory state and circulating erythropoietin in persons with and without anemia. Am J Med. 2005 Nov; 118(11):1288. PMID: 16271918.
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  113. Rezanka LJ, Kenny JJ, Longo DL. 2 BCR or NOT 2 BCR - receptor dilution: a unique mechanism for preventing the development of holes in the protective B cell repertoire. Immunobiology. 2005; 210(10):769-74. PMID: 16325496.
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  114. Longo DL. Radiation therapy in Hodgkin disease: why risk a Pyrrhic victory? J Natl Cancer Inst. 2005 Oct 05; 97(19):1394-5. PMID: 16204683.
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  115. Gulmann C, Espina V, Petricoin E, Longo DL, Santi M, Knutsen T, Raffeld M, Jaffe ES, Liotta LA, Feldman AL. Proteomic analysis of apoptotic pathways reveals prognostic factors in follicular lymphoma. Clin Cancer Res. 2005 Aug 15; 11(16):5847-55. PMID: 16115925.
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  116. Ershler WB, Sheng S, McKelvey J, Artz AS, Denduluri N, Tecson J, Taub DD, Brant LJ, Ferrucci L, Longo DL. Serum erythropoietin and aging: a longitudinal analysis. J Am Geriatr Soc. 2005 Aug; 53(8):1360-5. PMID: 16078962.
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  117. Taub DD, Longo DL. Insights into thymic aging and regeneration. Immunol Rev. 2005 Jun; 205:72-93. PMID: 15882346.
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  118. Sakatani T, Kaneda A, Iacobuzio-Donahue CA, Carter MG, de Boom Witzel S, Okano H, Ko MS, Ohlsson R, Longo DL, Feinberg AP. Loss of imprinting of Igf2 alters intestinal maturation and tumorigenesis in mice. Science. 2005 Mar 25; 307(5717):1976-8. PMID: 15731405.
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  119. Ferrucci L, Corsi A, Lauretani F, Bandinelli S, Bartali B, Taub DD, Guralnik JM, Longo DL. The origins of age-related proinflammatory state. Blood. 2005 Mar 15; 105(6):2294-9. PMID: 15572589.
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  120. O'Farrell TJ, Ghosh P, Dobashi N, Sasaki CY, Longo DL. Comparison of the effect of mutant and wild-type p53 on global gene expression. Cancer Res. 2004 Nov 15; 64(22):8199-207. PMID: 15548685.
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  121. Kusaba H, Ghosh P, Derin R, Buchholz M, Sasaki C, Madara K, Longo DL. Interleukin-12-induced interferon-gamma production by human peripheral blood T cells is regulated by mammalian target of rapamycin (mTOR). J Biol Chem. 2005 Jan 14; 280(2):1037-43. PMID: 15522880.
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  122. Westin EH, Longo DL. Lymphoma and myeloma in older patients. Semin Oncol. 2004 Apr; 31(2):198-205. PMID: 15112150.
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  123. Takahashi K, Reynolds M, Ogawa N, Longo DL, Burdick J. Augmentation of T-cell apoptosis by immunosuppressive agents. Clin Transplant. 2004; 18 Suppl 12:72-5. PMID: 15217412.
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  124. Sharov AA, Piao Y, Matoba R, Dudekula DB, Qian Y, VanBuren V, Falco G, Martin PR, Stagg CA, Bassey UC, Wang Y, Carter MG, Hamatani T, Aiba K, Akutsu H, Sharova L, Tanaka TS, Kimber WL, Yoshikawa T, Jaradat SA, Pantano S, Nagaraja R, Boheler KR, Taub D, Hodes RJ, Longo DL, Schlessinger D, Keller J, Klotz E, Kelsoe G, Umezawa A, Vescovi AL, Rossant J, Kunath T, Hogan BL, Curci A, D'Urso M, Kelso J, Hide W, Ko MS. Transcriptome analysis of mouse stem cells and early embryos. PLoS Biol. 2003 Dec; 1(3):E74. PMID: 14691545; PMCID: PMC300684.
  125. Yano S, Ghosh P, Kusaba H, Buchholz M, Longo DL. Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol. 2003 Sep 01; 171(5):2510-6. PMID: 12928400.
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  126. Longo DL. Radiation therapy in the treatment of Hodgkin's disease--do you see what I see? J Natl Cancer Inst. 2003 Jul 02; 95(13):928-9. PMID: 12837820.
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  127. Ferrucci L, Guralnik JM, Cavazzini C, Bandinelli S, Lauretani F, Bartali B, Repetto L, Longo DL. The frailty syndrome: a critical issue in geriatric oncology. Crit Rev Oncol Hematol. 2003 May; 46(2):127-37. PMID: 12711358.
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  128. Shack S, Wang XT, Kokkonen GC, Gorospe M, Longo DL, Holbrook NJ. Caveolin-induced activation of the phosphatidylinositol 3-kinase/Akt pathway increases arsenite cytotoxicity. Mol Cell Biol. 2003 Apr; 23(7):2407-14. PMID: 12640124; PMCID: PMC150728.
  129. Artz AS, Ershler WB, Longo DL. Pneumococcal vaccination and revaccination of older adults. Clin Microbiol Rev. 2003 Apr; 16(2):308-18. PMID: 12692100; PMCID: PMC153142.
  130. Rosenwald A, Wright G, Chan WC, Connors JM, Campo E, Fisher RI, Gascoyne RD, Muller-Hermelink HK, Smeland EB, Giltnane JM, Hurt EM, Zhao H, Averett L, Yang L, Wilson WH, Jaffe ES, Simon R, Klausner RD, Powell J, Duffey PL, Longo DL, Greiner TC, Weisenburger DD, Sanger WG, Dave BJ, Lynch JC, Vose J, Armitage JO, Montserrat E, López-Guillermo A, Grogan TM, Miller TP, LeBlanc M, Ott G, Kvaloy S, Delabie J, Holte H, Krajci P, Stokke T, Staudt LM. The use of molecular profiling to predict survival after chemotherapy for diffuse large-B-cell lymphoma. N Engl J Med. 2002 Jun 20; 346(25):1937-47. PMID: 12075054.
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  131. Ghosh P, Buchholz MA, Yano S, Taub D, Longo DL. Effect of rapamycin on the cyclosporin A-resistant CD28-mediated costimulatory pathway. Blood. 2002 Jun 15; 99(12):4517-24. PMID: 12036883.
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  132. Wilson WH, Grossbard ML, Pittaluga S, Cole D, Pearson D, Drbohlav N, Steinberg SM, Little RF, Janik J, Gutierrez M, Raffeld M, Staudt L, Cheson BD, Longo DL, Harris N, Jaffe ES, Chabner BA, Wittes R, Balis F. Dose-adjusted EPOCH chemotherapy for untreated large B-cell lymphomas: a pharmacodynamic approach with high efficacy. Blood. 2002 Apr 15; 99(8):2685-93. PMID: 11929754.
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  133. Mi QS, Rezanka LJ, Lustig A, Zhou L, Longo DL, Kenny JJ. The M603 idiotype is lost in the response to phosphocholine in terminal deoxynucleotidyl transferase-deficient mice. Eur J Immunol. 2002 Apr; 32(4):1139-46. PMID: 11932921.
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  134. Hu L, Rezanka LJ, Mi QS, Lustig A, Taub DD, Longo DL, Kenny JJ. T15-idiotype-negative B cells dominate the phosphocholine binding cells in the preimmune repertoire of T15i knockin mice. J Immunol. 2002 Feb 01; 168(3):1273-80. PMID: 11801665.
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  135. Luo Y, Long JM, Lu C, Chan SL, Spangler EL, Mascarucci P, Raz A, Longo DL, Mattson MP, Ingram DK, Weng NP. A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78. J Neurochem. 2002 Jan; 80(2):354-61. PMID: 11902125.
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  136. Luo Y, Long JM, Spangler EL, Longo DL, Ingram DK, Weng NP. Identification of maze learning-associated genes in rat hippocampus by cDNA microarray. J Mol Neurosci. 2001 Dec; 17(3):397-404. PMID: 11859936.
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  137. Janik JE, Miller LL, Korn EL, Stevens D, Curti BD, Smith JW, Sznol M, Conlon KC, Sharfman W, Urba WJ, Gause BL, Longo DL. A prospective randomized phase II trial of GM-CSF priming to prevent topotecan-induced neutropenia in chemotherapy-naive patients with malignant melanoma or renal cell carcinoma. Blood. 2001 Apr 01; 97(7):1942-6. PMID: 11264156.
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  138. Sasaki CY, Lin H, Morin PJ, Longo DL. Truncation of the extracellular region abrogrates cell contact but retains the growth-suppressive activity of E-cadherin. Cancer Res. 2000 Dec 15; 60(24):7057-65. PMID: 11156412.
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  139. Kenny JJ, Derby EG, Yoder JA, Hill SA, Fischer RT, Tucker PW, Claflin JL, Longo DL. Positive and negative selection of antigen-specific B cells in transgenic mice expressing variant forms of the V(H)1 (T15) heavy chain. Int Immunol. 2000 Jun; 12(6):873-85. PMID: 10837415.
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  140. Mi QS, Zhou L, Schulze DH, Fischer RT, Lustig A, Rezanka LJ, Donovan DM, Longo DL, Kenny JJ. Highly reduced protection against Streptococcus pneumoniae after deletion of a single heavy chain gene in mouse. Proc Natl Acad Sci U S A. 2000 May 23; 97(11):6031-6. PMID: 10811914; PMCID: PMC18553.
  141. Kalechman Y, Longo DL, Catane R, Shani A, Albeck M, Sredni B. Synergistic anti-tumoral effect of paclitaxel (Taxol)+AS101 in a murine model of B16 melanoma: association with ras-dependent signal-transduction pathways. Int J Cancer. 2000 Apr 15; 86(2):281-8. PMID: 10738258.
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  142. Kenny JJ, Rezanka LJ, Lustig A, Fischer RT, Yoder J, Marshall S, Longo DL. Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors. J Immunol. 2000 Apr 15; 164(8):4111-9. PMID: 10754305.
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  143. Kenny JJ, Lustig A, Longo DL. Positive selection of low affinity autoreactive B cells. Curr Top Microbiol Immunol. 2000; 252:39-45. PMID: 11125491.
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  144. Bendandi M, Gocke CD, Kobrin CB, Benko FA, Sternas LA, Pennington R, Watson TM, Reynolds CW, Gause BL, Duffey PL, Jaffe ES, Creekmore SP, Longo DL, Kwak LW. Complete molecular remissions induced by patient-specific vaccination plus granulocyte-monocyte colony-stimulating factor against lymphoma. Nat Med. 1999 Oct; 5(10):1171-7. PMID: 10502821.
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  145. Bendandi M, Longo DL. Biologic therapy for lymphoma. Curr Opin Oncol. 1999 Sep; 11(5):343-50. PMID: 10505770.
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  146. Srivastava RK, Sollott SJ, Khan L, Hansford R, Lakatta EG, Longo DL. Bcl-2 and Bcl-X(L) block thapsigargin-induced nitric oxide generation, c-Jun NH(2)-terminal kinase activity, and apoptosis. Mol Cell Biol. 1999 Aug; 19(8):5659-74. PMID: 10409755; PMCID: PMC84418.
  147. Srivastava RK, Sasaki CY, Hardwick JM, Longo DL. Bcl-2-mediated drug resistance: inhibition of apoptosis by blocking nuclear factor of activated T lymphocytes (NFAT)-induced Fas ligand transcription. J Exp Med. 1999 Jul 19; 190(2):253-65. PMID: 10432288; PMCID: PMC2195578.
  148. Srivastava RK, Srivastava AR, Cho-Chung YS, Longo DL. Synergistic effects of retinoic acid and 8-chloro-adenosine 3',5'-cyclic monophosphate on the regulation of retinoic acid receptor beta and apoptosis: involvement of mitochondria. Clin Cancer Res. 1999 Jul; 5(7):1892-904. PMID: 10430097.
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  149. Srivastava RK, Mi QS, Hardwick JM, Longo DL. Deletion of the loop region of Bcl-2 completely blocks paclitaxel-induced apoptosis. Proc Natl Acad Sci U S A. 1999 Mar 30; 96(7):3775-80. PMID: 10097113; PMCID: PMC22370.
  150. Srivastava RK, Srivastava AR, Cho-Chung YS, Longo DL. Synergistic effects of retinoic acid and 8-Cl-cAMP on apoptosis require caspase-3 activation in human ovarian cancer cells. Oncogene. 1999 Mar 04; 18(9):1755-63. PMID: 10208436.
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  151. Murphy WJ, Welniak LA, Taub DD, Wiltrout RH, Taylor PA, Vallera DA, Kopf M, Young H, Longo DL, Blazar BR. Differential effects of the absence of interferon-gamma and IL-4 in acute graft-versus-host disease after allogeneic bone marrow transplantation in mice. J Clin Invest. 1998 Nov 01; 102(9):1742-8. PMID: 9802888; PMCID: PMC509122.
  152. Longo DL. Interferon toxicity worse in retrospect; impact on Q-TWiST? Quality-Adjusted Time Without Symptoms or Toxicity. J Clin Oncol. 1998 Nov; 16(11):3716; author reply 3718. PMID: 9817297.
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  153. Curti BD, Ochoa AC, Powers GC, Kopp WC, Alvord WG, Janik JE, Gause BL, Dunn B, Kopreski MS, Fenton R, Zea A, Dansky-Ullmann C, Strobl S, Harvey L, Nelson E, Sznol M, Longo DL. Phase I trial of anti-CD3-stimulated CD4+ T cells, infusional interleukin-2, and cyclophosphamide in patients with advanced cancer. J Clin Oncol. 1998 Aug; 16(8):2752-60. PMID: 9704728.
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  154. Longo DL. Solving the puzzle of follicular lymphoma. Cancer J Sci Am. 1998 Jul; 4 Suppl 2:S1-4. PMID: 9672768.
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  155. Srivastava RK, Srivastava AR, Korsmeyer SJ, Nesterova M, Cho-Chung YS, Longo DL. Involvement of microtubules in the regulation of Bcl2 phosphorylation and apoptosis through cyclic AMP-dependent protein kinase. Mol Cell Biol. 1998 Jun; 18(6):3509-17. PMID: 9584191; PMCID: PMC108932.
  156. Little R, Wittes RE, Longo DL, Wilson WH. Vinblastine for recurrent Hodgkin's disease following autologous bone marrow transplant. J Clin Oncol. 1998 Feb; 16(2):584-8. PMID: 9469345.
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  157. Longo DL, Glatstein E, Duffey PL, Young RC, Ihde DC, Bastian AW, Wilson WH, Wittes RE, Jaffe ES, Hubbard SM, DeVita VT. Alternating MOPP and ABVD chemotherapy plus mantle-field radiation therapy in patients with massive mediastinal Hodgkin's disease. J Clin Oncol. 1997 Nov; 15(11):3338-46. PMID: 9363863.
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  158. Ershler WB, Longo DL. Aging and cancer: issues of basic and clinical science. J Natl Cancer Inst. 1997 Oct 15; 89(20):1489-97. PMID: 9337345.
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  159. Funakoshi S, Hirano A, Beckwith M, Asai O, Jorgensen G, Tian Z, Hornick JL, Hu P, Khawli LA, Epstein AL, Longo DL, Murphy WJ. Antitumor effects of nonconjugated murine Lym-2 and human-mouse chimeric CLL-1 monoclonal antibodies against various human lymphoma cell lines in vitro and in vivo. Blood. 1997 Oct 15; 90(8):3160-6. PMID: 9376598.
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  160. Ershler WB, Longo DL. The biology of aging: the current research agenda. Cancer. 1997 Oct 01; 80(7):1284-93. PMID: 9317181.
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  161. Correa MR, Ochoa AC, Ghosh P, Mizoguchi H, Harvey L, Longo DL. Sequential development of structural and functional alterations in T cells from tumor-bearing mice. J Immunol. 1997 Jun 01; 158(11):5292-6. PMID: 9164948.
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  162. Longo DL. You say tomato and I say tomahto: getting a handle on pronouncing apoptosis. J Natl Cancer Inst. 1997 May 07; 89(9):657. PMID: 9150191.
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  163. Uchiumi T, Longo DL, Ferris DK. Cell cycle regulation of the human polo-like kinase (PLK) promoter. J Biol Chem. 1997 Apr 04; 272(14):9166-74. PMID: 9083047.
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  164. Fenton RG, Longo DL. Danger versus tolerance: paradigms for future studies of tumor-specific cytotoxic T lymphocytes. J Natl Cancer Inst. 1997 Feb 19; 89(4):272-5. PMID: 9048827.
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  165. Taub DD, Key ML, Longo DL, Murphy WJ. Chemokine-induced human lymphocyte infiltration and engraftment in huPBL-SCID mice. Methods Enzymol. 1997; 287:265-91. PMID: 9330328.
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  166. Longo DL. Immunotherapy for non-Hodgkin's lymphoma. Curr Opin Oncol. 1996 Sep; 8(5):353-9. PMID: 8914801.
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  167. Gause BL, Longo DL. Treatment of relapsed Hodgkin's disease. Baillieres Clin Haematol. 1996 Sep; 9(3):559-72. PMID: 8922246.
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  168. Gause BL, Sznol M, Kopp WC, Janik JE, Smith JW, Steis RG, Urba WJ, Sharfman W, Fenton RG, Creekmore SP, Holmlund J, Conlon KC, VanderMolen LA, Longo DL. Phase I study of subcutaneously administered interleukin-2 in combination with interferon alfa-2a in patients with advanced cancer. J Clin Oncol. 1996 Aug; 14(8):2234-41. PMID: 8708712.
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  169. Rybak SM, Pearson JW, Fogler WE, Volker K, Spence SE, Newton DL, Mikulski SM, Ardelt W, Riggs CW, Kung HF, Longo DL. Enhancement of vincristine cytotoxicity in drug-resistant cells by simultaneous treatment with onconase, an antitumor ribonuclease. J Natl Cancer Inst. 1996 Jun 05; 88(11):747-53. PMID: 8637029.
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  170. Levitsky HI, Montgomery J, Ahmadzadeh M, Staveley-O'Carroll K, Guarnieri F, Longo DL, Kwak LW. Immunization with granulocyte-macrophage colony-stimulating factor-transduced, but not B7-1-transduced, lymphoma cells primes idiotype-specific T cells and generates potent systemic antitumor immunity. J Immunol. 1996 May 15; 156(10):3858-65. PMID: 8621924.
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  171. Weiler SR, Mou S, DeBerry CS, Keller JR, Ruscetti FW, Ferris DK, Longo DL, Linnekin D. JAK2 is associated with the c-kit proto-oncogene product and is phosphorylated in response to stem cell factor. Blood. 1996 May 01; 87(9):3688-93. PMID: 8611693.
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  172. Funakoshi S, Longo DL, Murphy WJ. Differential in vitro and in vivo antitumor effects mediated by anti-CD40 and anti-CD20 monoclonal antibodies against human B-cell lymphomas. J Immunother Emphasis Tumor Immunol. 1996 Mar; 19(2):93-101. PMID: 8732692.
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  173. Kopp WC, Urba WJ, Rager HC, Alvord WG, Oppenheim JJ, Smith JW, Longo DL. Induction of interleukin 1 receptor antagonist after interleukin 1 therapy in patients with cancer. Clin Cancer Res. 1996 Mar; 2(3):501-6. PMID: 9816196.
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  174. Chertov O, Michiel DF, Xu L, Wang JM, Tani K, Murphy WJ, Longo DL, Taub DD, Oppenheim JJ. Identification of defensin-1, defensin-2, and CAP37/azurocidin as T-cell chemoattractant proteins released from interleukin-8-stimulated neutrophils. J Biol Chem. 1996 Feb 09; 271(6):2935-40. PMID: 8621683.
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  175. Janik JE, Miller LL, Longo DL, Powers GC, Urba WJ, Kopp WC, Gause BL, Curti BD, Fenton RG, Oppenheim JJ, Conlon KC, Holmlund JT, Sznol M, Sharfman WH, Steis RG, Creekmore SP, Alvord WG, Beauchamp AE, Smith JW. Phase II trial of interleukin 1 alpha and indomethacin in treatment of metastatic melanoma. J Natl Cancer Inst. 1996 Jan 03; 88(1):44-9. PMID: 8847725.
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  176. Pinedo HM, Longo DL, Chabner BA. Cancer chemotherapy and biological response modifiers annual 16. Introduction. Cancer Chemother Biol Response Modif. 1996; 16:xvii-xviii. PMID: 8639378.
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  177. Longo DL. The case against the routine use of radiation therapy in advanced-stage Hodgkin's disease. Cancer Invest. 1996; 14(4):353-60. PMID: 8689431.
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  178. Zea AH, Curti BD, Longo DL, Alvord WG, Strobl SL, Mizoguchi H, Creekmore SP, O'Shea JJ, Powers GC, Urba WJ, et al. Alterations in T cell receptor and signal transduction molecules in melanoma patients. Clin Cancer Res. 1995 Nov; 1(11):1327-35. PMID: 9815928.
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  179. Ghosh P, Komschlies KL, Cippitelli M, Longo DL, Subleski J, Ye J, Sica A, Young HA, Wiltrout RH, Ochoa AC. Gradual loss of T-helper 1 populations in spleen of mice during progressive tumor growth. J Natl Cancer Inst. 1995 Oct 04; 87(19):1478-83. PMID: 7674335.
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  180. Hornung RL, Longo DL, Bowersox OC, Kwak LW. Tumor antigen-specific immunization of bone marrow transplantation donors as adoptive therapy against established tumor. J Natl Cancer Inst. 1995 Sep 06; 87(17):1289-96. PMID: 7544833.
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  181. Fenton RG, Longo DL. Genetic instability and tumor cell variation: implications for immunotherapy. J Natl Cancer Inst. 1995 Feb 15; 87(4):241-3. PMID: 7707413.
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  182. Sela S, Husain SR, Pearson JW, Longo DL, Rahman A. Reversal of multidrug resistance in human colon cancer cells expressing the human MDR1 gene by liposomes in combination with monoclonal antibody or verapamil. J Natl Cancer Inst. 1995 Jan 18; 87(2):123-8. PMID: 7707383.
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  183. Fogler WE, Pearson JW, Volker K, Ariyoshi K, Watabe H, Riggs CW, Wiltrout RH, Longo DL. Enhancement by recombinant human interferon alfa of the reversal of multidrug resistance by MRK-16 monoclonal antibody. J Natl Cancer Inst. 1995 Jan 18; 87(2):94-104. PMID: 7707396.
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  184. Holmund JT, Kopp WC, Wiltrout RH, Longo DL, Urba WJ, Janik JE, Sznol M, Conlon KC, Fenton RG, Hornung R, et al. A phase I clinical trial of flavone-8-acetic acid in combination with interleukin 2. J Natl Cancer Inst. 1995 Jan 18; 87(2):134-6. PMID: 7707385.
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  185. Longo DL, Duffey PL, Jaffe ES, Raffeld M, Hubbard SM, Fisher RI, Wittes RE, DeVita VT, Young RC. Diffuse small noncleaved-cell, non-Burkitt's lymphoma in adults: a high-grade lymphoma responsive to ProMACE-based combination chemotherapy. J Clin Oncol. 1994 Oct; 12(10):2153-9. PMID: 7523607.
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  186. Kwak LW, DeVita VT, Longo DL. Lymphomas. Cancer Chemother Biol Response Modif. 1994; 15:413-70. PMID: 7779591.
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  187. Horowitz ME, Kinsella TJ, Wexler LH, Belasco J, Triche T, Tsokos M, Steinberg SM, McClure L, Longo DL, Steis RG, et al. Total-body irradiation and autologous bone marrow transplant in the treatment of high-risk Ewing's sarcoma and rhabdomyosarcoma. J Clin Oncol. 1993 Oct; 11(10):1911-8. PMID: 8410118.
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  188. Murphy WJ, Reynolds CW, Tiberghien P, Longo DL. Natural killer cells and bone marrow transplantation. J Natl Cancer Inst. 1993 Sep 15; 85(18):1475-82. PMID: 8360930.
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  189. Longo DL, DeVita VT, Young RC. CHOP versus intensive regimens in non-Hodgkin's lymphoma. N Engl J Med. 1993 Aug 19; 329(8):580-1; author reply 581-2. PMID: 7687747.
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  190. Fenton RG, Taub DD, Kwak LW, Smith MR, Longo DL. Cytotoxic T-cell response and in vivo protection against tumor cells harboring activated ras proto-oncogenes. J Natl Cancer Inst. 1993 Aug 18; 85(16):1294-302. PMID: 8340941.
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  191. Phillips GL, Longo DL. Indications for high-dose therapy with hematopoietic support in patients with Hodgkin's disease. Leukemia. 1993 Jul; 7(7):1087-90. PMID: 8321031.
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  192. Pearson JW, Fogler WE, Volker K, Riggs CW, Gruys E, Groves ES, Wiltrout RH, Longo DL. Restoration of interferon alpha potentiation of a recombinant ricin A chain immunotoxin following cytoreduction of xenografts of advanced ovarian tumors. J Natl Cancer Inst. 1993 Jun 02; 85(11):907-12. PMID: 8492319.
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  193. Curti BD, Longo DL, Ochoa AC, Conlon KC, Smith JW, Alvord WG, Creekmore SP, Fenton RG, Gause BL, Holmlund J, et al. Treatment of cancer patients with ex vivo anti-CD3-activated killer cells and interleukin-2. J Clin Oncol. 1993 Apr; 11(4):652-60. PMID: 8257476.
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  194. Smith JW, Longo DL, Alvord WG, Janik JE, Sharfman WH, Gause BL, Curti BD, Creekmore SP, Holmlund JT, Fenton RG, et al. The effects of treatment with interleukin-1 alpha on platelet recovery after high-dose carboplatin. N Engl J Med. 1993 Mar 18; 328(11):756-61. PMID: 8437596.
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  195. Beckwith M, Urba WJ, Longo DL. Growth inhibition of human lymphoma cell lines by the marine products, dolastatins 10 and 15. J Natl Cancer Inst. 1993 Mar 17; 85(6):483-8. PMID: 8445676.
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  196. Longo DL. What's the deal with follicular lymphomas? J Clin Oncol. 1993 Feb; 11(2):202-8. PMID: 8426195.
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  197. Janik J, Kopp WC, Smith JW, Longo DL, Alvord WG, Sharfman WH, Fenton RG, Sznol M, Steis RG, Creekmore SP, et al. Dose-related immunologic effects of levamisole in patients with cancer. J Clin Oncol. 1993 Jan; 11(1):125-35. PMID: 8418223.
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  198. Sotos GA, Liebmann JE, Kohler DR, Longo DL. Reactivation of thermal burn by methotrexate. J Natl Cancer Inst. 1992 Dec 16; 84(24):1936-8. PMID: 1460675.
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  199. Urba WJ, Wilson WH, Duffey PL, Wittes R, Chabner BA, Longo DL. Recent National Cancer Institute lymphoma trials of etoposide-containing combination chemotherapy. Semin Oncol. 1992 Dec; 19(6 Suppl 13):26-32. PMID: 1283467.
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  200. Wilson WH, Jain V, Bryant G, Cowan KH, Carter C, Cottler-Fox M, Goldspiel B, Steinberg SM, Longo DL, Wittes RE. Phase I and II study of high-dose ifosfamide, carboplatin, and etoposide with autologous bone marrow rescue in lymphomas and solid tumors. J Clin Oncol. 1992 Nov; 10(11):1712-22. PMID: 1403054.
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  201. Murphy WJ, Longo DL. Hematopoietic growth-promoting effects of natural killer cells in mice in response to in vivo administration of human interleukin-2. J Natl Cancer Inst. 1992 Aug 05; 84(15):1195-200. PMID: 1635088.
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  202. Longo DL, Duffey PL, Hubbard SM, Young RC, DeVita VT. Radiation therapy is better than chemotherapy in early-stage Hodgkin's disease? Not so fast. J Clin Oncol. 1992 Aug; 10(8):1367-9. PMID: 1634930.
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  203. Ochoa JB, Curti B, Peitzman AB, Simmons RL, Billiar TR, Hoffman R, Rault R, Longo DL, Urba WJ, Ochoa AC. Increased circulating nitrogen oxides after human tumor immunotherapy: correlation with toxic hemodynamic changes. J Natl Cancer Inst. 1992 Jun 03; 84(11):864-7. PMID: 1375656.
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  204. Urba WJ, Longo DL. Hodgkin's disease. N Engl J Med. 1992 Mar 05; 326(10):678-87. PMID: 1736106.
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  205. Longo DL, Duffey PL, Young RC, Hubbard SM, Ihde DC, Glatstein E, Phares JC, Jaffe ES, Urba WJ, DeVita VT. Conventional-dose salvage combination chemotherapy in patients relapsing with Hodgkin's disease after combination chemotherapy: the low probability for cure. J Clin Oncol. 1992 Feb; 10(2):210-8. PMID: 1732422.
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  206. Longo DL. Effect of dietary fat on human breast cancer growth and lung metastasis in nude mice. J Natl Cancer Inst. 1992 Jan 15; 84(2):127. PMID: 1735878.
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  207. Pai LH, Bookman MA, Ozols RF, Young RC, Smith JW, Longo DL, Gould B, Frankel A, McClay EF, Howell S, et al. Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer. J Clin Oncol. 1991 Dec; 9(12):2095-103. PMID: 1960550.
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  208. Jacobsen SE, Ruscetti FW, Longo DL, Keller JR. Antineoplastic dolastatins: potent inhibitors of hematopoietic progenitor cells. J Natl Cancer Inst. 1991 Nov 20; 83(22):1672-7. PMID: 1749020.
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  209. Steis RG, Urba WJ, Kopp WC, Alvord WG, Smith JW, Longo DL. Kinetics of recovery of CD4+ T cells in peripheral blood of deoxycoformycin-treated patients. J Natl Cancer Inst. 1991 Nov 20; 83(22):1678-9. PMID: 1684207.
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  210. Longo DL, Duffey PL, DeVita VT, Wesley MN, Hubbard SM, Young RC. The calculation of actual or received dose intensity: a comparison of published methods. J Clin Oncol. 1991 Nov; 9(11):2042-51. PMID: 1941063.
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  211. Urba WJ, Kopp WC, Clark JW, Smith JW, Steis RG, Huber C, Coggin D, Longo DL. The in vivo immunomodulatory effects of recombinant interferon gamma plus recombinant tumor necrosis factor-alfa. J Clin Oncol. 1991 Oct; 9(10):1831-9. PMID: 1919633.
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  212. Longo DL, Duffey PL, DeVita VT, Wiernik PH, Hubbard SM, Phares JC, Bastian AW, Jaffe ES, Young RC. Treatment of advanced-stage Hodgkin's disease: alternating noncrossresistant MOPP/CABS is not superior to MOPP. J Clin Oncol. 1991 Aug; 9(8):1409-20. PMID: 1712836.
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  213. Longo DL, Glatstein E, Duffey PL, Young RC, Hubbard SM, Urba WJ, Wesley MN, Raubitschek A, Jaffe ES, Wiernik PH, et al. Radiation therapy versus combination chemotherapy in the treatment of early-stage Hodgkin's disease: seven-year results of a prospective randomized trial. J Clin Oncol. 1991 Jun; 9(6):906-17. PMID: 2033427.
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  214. Longo DL, Russo A, Duffey PL, Hubbard SM, Glatstein E, Hill JB, Jaffe ES, Young RC, DeVita VT. Treatment of advanced-stage massive mediastinal Hodgkin's disease: the case for combined modality treatment. J Clin Oncol. 1991 Feb; 9(2):227-35. PMID: 1988570.
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  215. Longo DL, DeVita VT, Duffey PL, Wesley MN, Ihde DC, Hubbard SM, Gilliom M, Jaffe ES, Cossman J, Fisher RI, et al. Superiority of ProMACE-CytaBOM over ProMACE-MOPP in the treatment of advanced diffuse aggressive lymphoma: results of a prospective randomized trial. J Clin Oncol. 1991 Jan; 9(1):25-38. PMID: 1702144.
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  216. Longo DL. Chemotherapy for advanced aggressive lymphoma: more is better ...isn't it? J Clin Oncol. 1990 Jun; 8(6):952-5. PMID: 2189956.
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  217. Bookman MA, Lardelli P, Jaffe ES, Duffey PL, Longo DL. Lymphocytic lymphoma of intermediate differentiation: morphologic, immunophenotypic, and prognostic factors. J Natl Cancer Inst. 1990 May 02; 82(9):742-8. PMID: 2182891.
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  218. Steis RG, VanderMolen LA, Longo DL, Clark JW, Smith JW, Kopp WC, Ruscetti FW, Creekmore SP, Elwood LJ, Hursey J, et al. Recombinant human granulocyte-macrophage colony-stimulating factor in patients with advanced malignancy: a phase Ib trial. J Natl Cancer Inst. 1990 Apr 18; 82(8):697-703. PMID: 2138680.
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  219. Martin A, Nerenstone S, Urba WJ, Longo DL, Lawrence JB, Clark JW, Hawkins MJ, Creekmore SP, Smith JW, Steis RG. Treatment of hairy cell leukemia with alternating cycles of pentostatin and recombinant leukocyte A interferon: results of a phase II study. J Clin Oncol. 1990 Apr; 8(4):721-30. PMID: 2313337.
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  220. Beckwith M, Longo DL, O'Connell CD, Moratz CM, Urba WJ. Phorbol ester-induced, cell-cycle-specific, growth inhibition of human B-lymphoma cell lines. J Natl Cancer Inst. 1990 Mar 21; 82(6):501-9. PMID: 2313723.
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  221. Bridges SH, Longo DL. T cell tumor cure by T cell receptor-mediated activation requires the development of CD8-dependent host immunity. J Immunol. 1990 Mar 01; 144(5):2010-7. PMID: 2155271.
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  222. Kohn EC, Steis RG, Sausville EA, Veach SR, Stocker JL, Phelps R, Franco S, Longo DL, Bunn PA, Ihde DC. Phase II trial of intermittent high-dose recombinant interferon alfa-2a in mycosis fungoides and the Sézary syndrome. J Clin Oncol. 1990 Jan; 8(1):155-60. PMID: 2295906.
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  223. Longo DL. Combined modality therapy for localized aggressive lymphoma: enough or too much? J Clin Oncol. 1989 Sep; 7(9):1179-81. PMID: 2769325.
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  224. Longo DL, Glatstein E, Duffey PL, Ihde DC, Hubbard SM, Fisher RI, Jaffe ES, Gilliom M, Young RC, DeVita VT. Treatment of localized aggressive lymphomas with combination chemotherapy followed by involved-field radiation therapy. J Clin Oncol. 1989 Sep; 7(9):1295-302. PMID: 2788716.
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  225. Hartmann LC, Urba WJ, Steis RG, Smith JW, Vander Molen LA, Creekmore SP, Sznol M, Casciano MA, Engler N, Longo DL. Use of prophylactic antibiotics for prevention of intravascular catheter-related infections in interleukin-2-treated patients. J Natl Cancer Inst. 1989 Aug 02; 81(15):1190-3. PMID: 2787409.
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  226. Hartmann LC, Urba WJ, Steis RG, Smith JW, VanderMolen L, Creekmore SP, Longo DL. Hypothyroidism after interleukin-2 therapy. J Clin Oncol. 1989 May; 7(5):686-7. PMID: 2785167.
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  227. Surbone A, Longo DL, DeVita VT, Ihde DC, Duffey PL, Jaffe ES, Solomon D, Hubbard SM, Young RC. Residual abdominal masses in aggressive non-Hodgkin's lymphoma after combination chemotherapy: significance and management. J Clin Oncol. 1988 Dec; 6(12):1832-7. PMID: 3199167.
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  228. Whang-Peng J, Lee EC, Minna JD, Abeloff MD, Bradley EC, Young RC, Longo DL. Deletion of 3(p14p23) in secondary erythroleukemia arising in long-term survivors of small cell lung cancer. J Natl Cancer Inst. 1988 Oct 05; 80(15):1253-5. PMID: 2843653.
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  229. VanderMolen LA, Swain S, Longo DL. Lactic acidosis in lymphoma: prompt resolution of acidosis with therapy directed at the lymphoma. J Natl Cancer Inst. 1988 Sep 07; 80(13):1077-8. PMID: 3411621.
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  230. Ortaldo JR, Longo DL. Human natural lymphocyte effector cells: definition, analysis of activity, and clinical effectiveness. J Natl Cancer Inst. 1988 Sep 07; 80(13):999-1010. PMID: 3045334.
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  231. Steis RG, Smith JW, Urba WJ, Clark JW, Itri LM, Evans LM, Schoenberger C, Longo DL. Resistance to recombinant interferon alfa-2a in hairy-cell leukemia associated with neutralizing anti-interferon antibodies. N Engl J Med. 1988 Jun 02; 318(22):1409-13. PMID: 3367950.
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  232. Urba WJ, Longo DL, Lombardo FA, Weiss RB. Enhancement of natural killer activity in human peripheral blood by flavone acetic acid. J Natl Cancer Inst. 1988 Jun 01; 80(7):521-5. PMID: 2452890.
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  233. Miser JS, Kinsella TJ, Triche TJ, Tsokos M, Forquer R, Wesley R, Horvath K, Belasco J, Longo DL, Steis R, et al. Preliminary results of treatment of Ewing's sarcoma of bone in children and young adults: six months of intensive combined modality therapy without maintenance. J Clin Oncol. 1988 Mar; 6(3):484-90. PMID: 3280743.
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  234. Maluish AE, Urba WJ, Longo DL, Overton WR, Coggin D, Crisp ER, Williams R, Sherwin SA, Gordon K, Steis RG. The determination of an immunologically active dose of interferon-gamma in patients with melanoma. J Clin Oncol. 1988 Mar; 6(3):434-45. PMID: 3127550.
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  235. Miser JS, Kinsella TJ, Triche TJ, Steis R, Tsokos M, Wesley R, Horvath K, Belasco J, Longo DL, Glatstein E, et al. Treatment of peripheral neuroepithelioma in children and young adults. J Clin Oncol. 1987 Nov; 5(11):1752-8. PMID: 3316513.
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  236. Blayney DW, Longo DL, Young RC, Greene MH, Hubbard SM, Postal MG, Duffey PL, DeVita VT. Decreasing risk of leukemia with prolonged follow-up after chemotherapy and radiotherapy for Hodgkin's disease. N Engl J Med. 1987 Mar 19; 316(12):710-4. PMID: 3821809.
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  237. Longo DL, Young RC, Duffey PL, Hubbard SM, DeVita VT. MOPP after two decades. J Clin Oncol. 1987 Feb; 5(2):320-1. PMID: 3806177.
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  238. DeVita VT, Longo DL, Hubbard SM, Young RC, Chabner BA. The lymphomas: biologic implications of therapy and therapeutic implications of the new biology. Monogr Pathol. 1987; (29):249-67. PMID: 3295522.
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  239. Longo DL, Hathorn J. Current therapy for diffuse large-cell lymphoma. Prog Hematol. 1987; 15:115-36. PMID: 3332388.
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  240. Longo DL, Young RC, Wesley M, Hubbard SM, Duffey PL, Jaffe ES, DeVita VT. Twenty years of MOPP therapy for Hodgkin's disease. J Clin Oncol. 1986 Sep; 4(9):1295-306. PMID: 3528400.
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  241. Dmitrovsky E, Martin SE, Krudy AG, Chu EW, Jaffe ES, Longo DL, Young RC. Lymph node aspiration in the management of Hodgkin's disease. J Clin Oncol. 1986 Mar; 4(3):306-10. PMID: 3950673.
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  242. Kant JA, Hubbard SM, Longo DL, Simon RM, DeVita VT, Jaffe ES. The pathologic and clinical heterogeneity of lymphocyte-depleted Hodgkin's disease. J Clin Oncol. 1986 Mar; 4(3):284-94. PMID: 3754003.
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  243. Browne MJ, Hubbard SM, Longo DL, Fisher R, Wesley R, Ihde DC, Young RC, Pizzo PA. Excess prevalence of Pneumocystis carinii pneumonia in patients treated for lymphoma with combination chemotherapy. Ann Intern Med. 1986 Mar; 104(3):338-44. PMID: 3511821.
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  244. Raffeld M, Neckers L, Longo DL, Cossman J. Spontaneous alteration of idiotype in a monoclonal B-cell lymphoma. Escape from detection by anti-idiotype. N Engl J Med. 1985 Jun 27; 312(26):1653-8. PMID: 3923351.
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  245. Geffen DB, Fisher RI, Longo DL, Young RC, DeVita VT. Renal involvement in diffuse aggressive lymphomas: results of treatment with combination chemotherapy. J Clin Oncol. 1985 May; 3(5):646-53. PMID: 3998781.
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  246. Foon KA, Sherwin SA, Abrams PG, Longo DL, Fer MF, Stevenson HC, Ochs JJ, Bottino GC, Schoenberger CS, Zeffren J, et al. Treatment of advanced non-Hodgkin's lymphoma with recombinant leukocyte A interferon. N Engl J Med. 1984 Nov 01; 311(18):1148-52. PMID: 6482933.
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  247. Lane HC, Masur H, Longo DL, Klein HG, Rook AH, Quinnan GV, Steis RG, Macher A, Whalen G, Edgar LC, et al. Partial immune reconstitution in a patient with the acquired immunodeficiency syndrome. N Engl J Med. 1984 Oct 25; 311(17):1099-103. PMID: 6384784.
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  248. Averbuch SD, Austin HA, Sherwin SA, Antonovych T, Bunn PA, Longo DL. Acute interstitial nephritis with the nephrotic syndrome following recombinant leukocyte a interferon therapy for mycosis fungoides. N Engl J Med. 1984 Jan 05; 310(1):32-5. PMID: 6689738.
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  249. Macher AM, Reichert CM, Straus SE, Longo DL, Parrillo J, Lane HC, Fauci AS, Rook AH, Manischewitz JF, Quinnan GV. Death in the AIDS patient: role of cytomegalovirus. N Engl J Med. 1983 Dec 08; 309(23):1454. PMID: 6314141.
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  250. Fisher RI, DeVita VT, Hubbard SM, Longo DL, Wesley R, Chabner BA, Young RC. Diffuse aggressive lymphomas: increased survival after alternating flexible sequences of proMACE and MOPP chemotherapy. Ann Intern Med. 1983 Mar; 98(3):304-9. PMID: 6600902.
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  251. Longo DL. More on lithium and leukemia. N Engl J Med. 1980 Jul 31; 303(5):283. PMID: 7383116.
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  252. Kirkland TN, Sieckmann DG, Longo DL, Mosier DE. Cellular requirements for antigen presentation in the induction of a thymus-independent antibody response in vitro. J Immunol. 1980 Apr; 124(4):1721-6. PMID: 6965958.
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  253. Brereton HD, Young RC, Longo DL, Kirkland LR, Berard CW, Jaffe ES, DeVita VT, Johnson RE. A comparison between combination chemotherapy and total body irradiation plus combination chemotherapy in non-Hodgkin's lymphoma. Cancer. 1979 Jun; 43(6):2227-31. PMID: 378350.
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