Contact, publication, and social network information about Harvard faculty and fellows. Harvard Catalyst Profiles
Last Name

Chuan Wu, Ph.D.

TitleInstructor in Neurology
InstitutionBrigham and Women's Hospital
AddressHarvard Medical School
333 Longwood Ave
Boston MA 02115
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 awards and honors
2015 - 2014 Harvard Chinese Life Sciences Research Award, Harvard Medical School
2014 - 2017K99 NIH Pathway to Independence Award
2014 - 2019National Multiple Sclerosis Society Career Transition Award, USA
2013 - Regeneron Prize for Outstanding Research, USA
2013 - 2012 Harvard Chinese Life Sciences Research Award, Harvard Medical School
2013 - The American Association of Immunologists (AAI) Trainee Abstract Award, USA
2013 - National Multiple Sclerosis Society Postdoctoral Fellowship Award, USA
2009 - Eckhart-Buddecke prize for Pro Scientia-Preises der Eckhart-Buddecke-Stiftung, Münster University
2009 - PhD student with outstanding performance (summa cum laude), Münster University, Germany
2004 - 2005Medical Faculty Stipend, Lund University, Sweden

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 selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Safa K, Ohori S, Borges TJ, Uehara M, Batal I, Shimizu T, Magee CN, Belizaire R, Abdi R, Wu C, Chandraker A, Riella LV. Salt Accelerates Allograft Rejection through Serum- and Glucocorticoid-Regulated Kinase-1-Dependent Inhibition of Regulatory T Cells. J Am Soc Nephrol. 2015 Oct; 26(10):2341-7.
    View in: PubMed
  2. Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schäfers M, Körner H, Opdenakker G, Hallmann R, Sorokin L. Focal MMP-2 and MMP-9 Activity at the Blood-Brain Barrier Promotes Chemokine-Induced Leukocyte Migration. Cell Rep. 2015 Feb 24; 10(7):1040-54.
    View in: PubMed
  3. Wu C, Chen Z, Kuchroo VK. Ezh2 lines up the chromatin in T regulatory cells. Immunity. 2015 Feb 17; 42(2):201-3.
    View in: PubMed
  4. Wu C, Chen Z, Kuchroo VK. DUBA-UBR5 axis: other than transactivation. Cell Res. 2015 Mar; 25(3):273-4.
    View in: PubMed
  5. Zhu C, Sakuishi K, Xiao S, Sun Z, Zaghouani S, Gu G, Wang C, Tan DJ, Wu C, Rangachari M, Pertel T, Jin HT, Ahmed R, Anderson AC, Kuchroo VK. An IL-27/NFIL3 signalling axis drives Tim-3 and IL-10 expression and T-cell dysfunction. Nat Commun. 2015; 6:6072.
    View in: PubMed
  6. Wu C, Thalhamer T, Franca RF, Xiao S, Wang C, Hotta C, Zhu C, Hirashima M, Anderson AC, Kuchroo VK. Galectin-9-CD44 interaction enhances stability and function of adaptive regulatory T cells. Immunity. 2014 Aug 21; 41(2):270-82.
    View in: PubMed
  7. Yeste A, Mascanfroni ID, Nadeau M, Burns EJ, Tukpah AM, Santiago A, Wu C, Patel B, Kumar D, Quintana FJ. IL-21 induces IL-22 production in CD4+ T cells. Nat Commun. 2014; 5:3753.
    View in: PubMed
  8. Xiao S, Yosef N, Yang J, Wang Y, Zhou L, Zhu C, Wu C, Baloglu E, Schmidt D, Ramesh R, Lobera M, Sundrud MS, Tsai PY, Xiang Z, Wang J, Xu Y, Lin X, Kretschmer K, Rahl PB, Young RA, Zhong Z, Hafler DA, Regev A, Ghosh S, Marson A, Kuchroo VK. Small-molecule ROR?t antagonists inhibit T helper 17 cell transcriptional network by divergent mechanisms. Immunity. 2014 Apr 17; 40(4):477-89.
    View in: PubMed
  9. Zhang X, Wu C, Song J, Götte M, Sorokin L. Syndecan-1, a cell surface proteoglycan, negatively regulates initial leukocyte recruitment to the brain across the choroid plexus in murine experimental autoimmune encephalomyelitis. J Immunol. 2013 Nov 1; 191(9):4551-61.
    View in: PubMed
  10. Zhu B, Buttrick T, Bassil R, Zhu C, Olah M, Wu C, Xiao S, Orent W, Elyaman W, Khoury SJ. IL-4 and retinoic acid synergistically induce regulatory dendritic cells expressing Aldh1a2. J Immunol. 2013 Sep 15; 191(6):3139-51.
    View in: PubMed
  11. Song J, Lokmic Z, Lämmermann T, Rolf J, Wu C, Zhang X, Hallmann R, Hannocks MJ, Horn N, Ruegg MA, Sonnenberg A, Georges-Labouesse E, Winkler TH, Kearney JF, Cardell S, Sorokin L. Extracellular matrix of secondary lymphoid organs impacts on B-cell fate and survival. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):E2915-24.
    View in: PubMed
  12. Wu C, Pot C, Apetoh L, Thalhamer T, Zhu B, Murugaiyan G, Xiao S, Lee Y, Rangachari M, Yosef N, Kuchroo VK. Metallothioneins negatively regulate IL-27-induced type 1 regulatory T-cell differentiation. Proc Natl Acad Sci U S A. 2013 May 7; 110(19):7802-7.
    View in: PubMed
  13. Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo VK. Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature. 2013 Apr 25; 496(7446):513-7.
    View in: PubMed
  14. Yosef N, Shalek AK, Gaublomme JT, Jin H, Lee Y, Awasthi A, Wu C, Karwacz K, Xiao S, Jorgolli M, Gennert D, Satija R, Shakya A, Lu DY, Trombetta JJ, Pillai MR, Ratcliffe PJ, Coleman ML, Bix M, Tantin D, Park H, Kuchroo VK, Regev A. Dynamic regulatory network controlling TH17 cell differentiation. Nature. 2013 Apr 25; 496(7446):461-8.
    View in: PubMed
  15. Song J, Wu C, Zhang X, Sorokin LM. In vivo processing of CXCL5 (LIX) by matrix metalloproteinase (MMP)-2 and MMP-9 promotes early neutrophil recruitment in IL-1ß-induced peritonitis. J Immunol. 2013 Jan 1; 190(1):401-10.
    View in: PubMed
  16. Lee Y, Awasthi A, Yosef N, Quintana FJ, Xiao S, Peters A, Wu C, Kleinewietfeld M, Kunder S, Hafler DA, Sobel RA, Regev A, Kuchroo VK. Induction and molecular signature of pathogenic TH17 cells. Nat Immunol. 2012 Oct; 13(10):991-9.
    View in: PubMed
  17. Xiao S, Brooks CR, Zhu C, Wu C, Sweere JM, Petecka S, Yeste A, Quintana FJ, Ichimura T, Sobel RA, Bonventre JV, Kuchroo VK. Defect in regulatory B-cell function and development of systemic autoimmunity in T-cell Ig mucin 1 (Tim-1) mucin domain-mutant mice. Proc Natl Acad Sci U S A. 2012 Jul 24; 109(30):12105-10.
    View in: PubMed
  18. Zhu B, Kennedy JK, Wang Y, Sandoval-Garcia C, Cao L, Xiao S, Wu C, Elyaman W, Khoury SJ. Plasticity of Ly-6C(hi) myeloid cells in T cell regulation. J Immunol. 2011 Sep 1; 187(5):2418-32.
    View in: PubMed
  19. Korpos E, Wu C, Song J, Hallmann R, Sorokin L. Role of the extracellular matrix in lymphocyte migration. Cell Tissue Res. 2010 Jan; 339(1):47-57.
    View in: PubMed
  20. Wu C, Rauch U, Korpos E, Song J, Loser K, Crocker PR, Sorokin LM. Sialoadhesin-positive macrophages bind regulatory T cells, negatively controlling their expansion and autoimmune disease progression. J Immunol. 2009 May 15; 182(10):6508-16.
    View in: PubMed
  21. Wu C, Ivars F, Anderson P, Hallmann R, Vestweber D, Nilsson P, Robenek H, Tryggvason K, Song J, Korpos E, Loser K, Beissert S, Georges-Labouesse E, Sorokin LM. Endothelial basement membrane laminin alpha5 selectively inhibits T lymphocyte extravasation into the brain. Nat Med. 2009 May; 15(5):519-27.
    View in: PubMed
  22. Korpos E, Wu C, Sorokin L. Multiple roles of the extracellular matrix in inflammation. Curr Pharm Des. 2009; 15(12):1349-57.
    View in: PubMed
  23. Zhang YX, Li J, Guo XK, Wu C, Bi B, Ren SX, Wu CF, Zhao GP. Characterization of a novel toxin-antitoxin module, VapBC, encoded by Leptospira interrogans chromosome. Cell Res. 2004 Jun; 14(3):208-16.
    View in: PubMed
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