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Last Name

profileKarin Jensen, Ph.D.

TitleAssistant Professor of Psychology in the Department of Psychiatry
InstitutionMassachusetts General Hospital
Address120 Second Ave
Suite 101
Charlestown MA 02129
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Neuroimaging of pain and placebo analgesia

A major part of my research has focused on the role of the brain in chronic pain. In a series of studies, I used functional neuroimaging to elucidate the neural correlates to patients’ impaired ability to modulate pain, the high comorbidity with negative affect and the response to different types of treatment.

As an extension of the results from my studies of chronic pain, my postdoctoral work has focused on placebo analgesia. In particular I am interested in the neurobiology of the doctor-patient relationship - one of the main contributors to placebo effects.

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jensen KB, Kirsch I, Pontén M, Rosén A, Yang K, Gollub RL, des Portes V, Kaptchuk TJ, Curie A. Certainty of genuine treatment increases drug responses among intellectually disabled patients. Neurology. 2017 Apr 19. PMID: 28424273.
    View in: PubMed
  2. Kosek E, Rosen A, Carville S, Choy E, Gracely RH, Marcus H, Petzke F, Ingvar M, Jensen KB. Lower placebo responses after long-term exposure to fibromyalgia pain. J Pain. 2017 Mar 06. PMID: 28279705.
    View in: PubMed
  3. Berna C, Kirsch I, Zion SR, Lee YC, Jensen KB, Sadler P, Kaptchuk TJ, Edwards RR. Side effects can enhance treatment response through expectancy effects: an experimental analgesic randomized controlled trial. Pain. 2017 Feb 04. PMID: 28178072.
    View in: PubMed
  4. Kosek E, Martinsen S, Gerdle B, Mannerkorpi K, Löfgren M, Bileviciute-Ljungar I, Fransson P, Schalling M, Ingvar M, Ernberg M, Jensen KB. The translocator protein gene is associated with symptom severity and cerebral pain processing in fibromyalgia. Brain Behav Immun. 2016 Nov; 58:218-227. PMID: 27448744.
    View in: PubMed
  5. Jensen KB, Regenbogen C, Ohse MC, Frasnelli J, Freiherr J, Lundström JN. Brain activations during pain: a neuroimaging meta-analysis of patients with pain and healthy controls. Pain. 2016 Jun; 157(6):1279-86. PMID: 26871535.
    View in: PubMed
  6. Curie A, Yang K, Kirsch I, Gollub RL, des Portes V, Kaptchuk TJ, Jensen KB. Placebo Responses in Genetically Determined Intellectual Disability: A Meta-Analysis. PLoS One. 2015; 10(7):e0133316. PMID: 26226597; PMCID: PMC4520690.
  7. Jensen KB, Kaptchuk TJ, Chen X, Kirsch I, Ingvar M, Gollub RL, Kong J. A Neural Mechanism for Nonconscious Activation of Conditioned Placebo and Nocebo Responses. Cereb Cortex. 2015 Oct; 25(10):3903-10. PMID: 25452576; PMCID: PMC4585522.
  8. Jensen KB, Petzke F, Carville S, Choy E, Fransson P, Gracely RH, Vitton O, Marcus H, Williams SC, Ingvar M, Kosek E. Segregating the cerebral mechanisms of antidepressants and placebo in fibromyalgia. J Pain. 2014 Dec; 15(12):1328-37. PMID: 25283470.
    View in: PubMed
  9. Hsieh C, Kong J, Kirsch I, Edwards RR, Jensen KB, Kaptchuk TJ, Gollub RL. Well-loved music robustly relieves pain: a randomized, controlled trial. PLoS One. 2014; 9(9):e107390. PMID: 25211164; PMCID: PMC4161415.
  10. Jensen KB, Srinivasan P, Spaeth R, Tan Y, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Vitton O, Gracely R, Ingvar M, Kong J. Overlapping structural and functional brain changes in patients with long-term exposure to fibromyalgia pain. Arthritis Rheum. 2013 Dec; 65(12):3293-303. PMID: 23982850; PMCID: PMC3984030.
  11. Kong J, Spaeth RB, Wey HY, Cheetham A, Cook AH, Jensen K, Tan Y, Liu H, Wang D, Loggia ML, Napadow V, Smoller JW, Wasan AD, Gollub RL. S1 is associated with chronic low back pain: a functional and structural MRI study. Mol Pain. 2013 Aug 21; 9:43. PMID: 23965184; PMCID: PMC3765748.
  12. Jensen KB, Petrovic P, Kerr CE, Kirsch I, Raicek J, Cheetham A, Spaeth R, Cook A, Gollub RL, Kong J, Kaptchuk TJ. Sharing pain and relief: neural correlates of physicians during treatment of patients. Mol Psychiatry. 2014 Mar; 19(3):392-8. PMID: 23358155; PMCID: PMC3981541.
  13. Mohan R, Jensen KB, Petkova VI, Dey A, Barnsley N, Ingvar M, McAuley JH, Moseley GL, Ehrsson HH. No pain relief with the rubber hand illusion. PLoS One. 2012; 7(12):e52400. PMID: 23285026; PMCID: PMC3527497.
  14. Kong J, Jensen K, Loiotile R, Cheetham A, Wey HY, Tan Y, Rosen B, Smoller JW, Kaptchuk TJ, Gollub RL. Functional connectivity of the frontoparietal network predicts cognitive modulation of pain. Pain. 2013 Mar; 154(3):459-67. PMID: 23352757; PMCID: PMC3725961.
  15. Hall KT, Lembo AJ, Kirsch I, Ziogas DC, Douaiher J, Jensen KB, Conboy LA, Kelley JM, Kokkotou E, Kaptchuk TJ. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS One. 2012; 7(10):e48135. PMID: 23110189; PMCID: PMC3479140.
  16. Wicksell RK, Kemani M, Jensen K, Kosek E, Kadetoff D, Sorjonen K, Ingvar M, Olsson GL. Acceptance and commitment therapy for fibromyalgia: a randomized controlled trial. Eur J Pain. 2013 Apr; 17(4):599-611. PMID: 23090719.
    View in: PubMed
  17. Jensen KB, Kaptchuk TJ, Kirsch I, Raicek J, Lindstrom KM, Berna C, Gollub RL, Ingvar M, Kong J. Nonconscious activation of placebo and nocebo pain responses. Proc Natl Acad Sci U S A. 2012 Sep 25; 109(39):15959-64. PMID: 23019380; PMCID: PMC3465419.
  18. Jensen KB, Kosek E, Wicksell R, Kemani M, Olsson G, Merle JV, Kadetoff D, Ingvar M. Cognitive Behavioral Therapy increases pain-evoked activation of the prefrontal cortex in patients with fibromyalgia. Pain. 2012 Jul; 153(7):1495-503. PMID: 22617632.
    View in: PubMed
  19. Jensen KB, Loitoile R, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Mainguy Y, Vitton O, Gracely RH, Gollub R, Ingvar M, Kong J. Patients with fibromyalgia display less functional connectivity in the brain's pain inhibitory network. Mol Pain. 2012 Apr 26; 8:32. PMID: 22537768; PMCID: PMC3404927.
  20. Jensen KB, Berna C, Loggia ML, Wasan AD, Edwards RR, Gollub RL. The use of functional neuroimaging to evaluate psychological and other non-pharmacological treatments for clinical pain. Neurosci Lett. 2012 Jun 29; 520(2):156-64. PMID: 22445888; PMCID: PMC3810294.
  21. Linnman C, Beucke JC, Jensen KB, Gollub RL, Kong J. Sex similarities and differences in pain-related periaqueductal gray connectivity. Pain. 2012 Feb; 153(2):444-54. PMID: 22154332; PMCID: PMC3558685.
  22. Loggia ML, Jensen K, Gollub RL, Wasan AD, Edwards RR, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS One. 2011; 6(11):e27764. PMID: 22132136; PMCID: PMC3221673.
  23. Zyloney CE, Jensen K, Polich G, Loiotile RE, Cheetham A, LaViolette PS, Tu P, Kaptchuk TJ, Gollub RL, Kong J. Imaging the functional connectivity of the Periaqueductal Gray during genuine and sham electroacupuncture treatment. Mol Pain. 2010 Nov 16; 6:80. PMID: 21080967; PMCID: PMC2993660.
  24. Jensen KB, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Mainguy Y, Gracely R, Ingvar M, Kosek E. Anxiety and depressive symptoms in fibromyalgia are related to poor perception of health but not to pain sensitivity or cerebral processing of pain. Arthritis Rheum. 2010 Nov; 62(11):3488-95. PMID: 20617526.
    View in: PubMed
  25. Jensen KB. Brain mechanisms in pain regulation. 2009.
  26. Kosek E, Jensen KB, Lonsdorf TB, Schalling M, Ingvar M. Genetic variation in the serotonin transporter gene (5-HTTLPR, rs25531) influences the analgesic response to the short acting opioid Remifentanil in humans. Mol Pain. 2009 Jul 01; 5:37. PMID: 19570226; PMCID: PMC2717925.
  27. Jensen KB, Lonsdorf TB, Schalling M, Kosek E, Ingvar M. Increased sensitivity to thermal pain following a single opiate dose is influenced by the COMT val(158)met polymorphism. PLoS One. 2009 Jun 23; 4(6):e6016. PMID: 19547755; PMCID: PMC2695541.
  28. Jensen KB, Kosek E, Petzke F, Carville S, Fransson P, Marcus H, Williams SC, Choy E, Giesecke T, Mainguy Y, Gracely R, Ingvar M. Evidence of dysfunctional pain inhibition in Fibromyalgia reflected in rACC during provoked pain. Pain. 2009 Jul; 144(1-2):95-100. PMID: 19410366.
    View in: PubMed
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