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David Dowling, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 75N93019C00044 (David Dowling) Apr 30, 2022 - Apr 30, 2024
    NIH/NIAID
    Advancement of TLR7/8 Adjuvant Development
    Role Description: This contract supplement supports the development of novel TLR7/8 agonist adjuvants for use in influenza and coronavirus vaccines.
  2. TDF2019 (David Dowling) Jul 30, 2021 - Sep 30, 2023
    Boston Children’s Hospital Technology Development Fund
    Adjuvant optimization via structure-activity relationship studies
    Role Description: This award advances the clinical development of patented adjuvants developed within the Dowling Laboratory.
  3. 75N93020C00038 (David Dowling) Oct 1, 2020 - Sep 30, 2025
    NIH/NIAID
    Development of Vaccines for the Treatment of Opioid Use Disorder
    Role Description: This contract is to develop an effective adjuvanted anti-fentanyl vaccine via the induction of anti-fentanyl antibodies that will block the movement of fentanyl from the bloodstream to the brain where it can suppress respiration and cause death. The production of vaccine formulation pilot lots will be completed under good laboratory practice (GLP) to support Investigational New Drug application (IND)-enabling activities in preparation for chemistry, manufacturing, and control (CMC) process-development and current Good Manufacturing Practice (cGMP) production grade formulation scaled up, to support animal and early-stage Phase I/II safety and immunogenicity human clinical trials in adults and/or youths with opioid use disorder (OUD).
    Role: Principal Investigator
  4. 75N93019C00044 (David Dowling) Apr 30, 2020 - Sep 30, 2022
    NIH/NIAID
    Vaccine Adjuvant Discovery Program - SARS-CoV-2 Vaccine Development
    Role Description: This contract focuses on development of novel adjuvanted SARS-CoV-2 vaccines tailored for use in older humans.
  5. 75N93019C00044 (David Dowling) Oct 1, 2019 - Sep 30, 2024
    NIH/NIAID
    Vaccine Adjuvant Discovery Program
    Role Description: This contract is to discover novel adjuvants for influenza and coronavirus vaccines by screening ~100,000 small molecules for activity towards human leukocytes, including newborn and elderly leukocytes, define mechanisms of action, and develop formulated analogs for in vivo murine and ferret studies.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Weitzman ER, Kossowsky J, Blakemore LM, Cox R, Dowling DJ, Levy O, Needles EW, Levy S. Acceptability of a Fentanyl Vaccine to Prevent Opioid Overdose and Need for Personalized Decision-Making. Clin Infect Dis. 2022 Aug 15; 75(Supplement_1):S98-S109. PMID: 35579508; PMCID: PMC9376272.
    Citations:    Fields:    
  2. Dowling DJ, Levy O. A Precision Adjuvant Approach to Enhance Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Vaccines Optimized for Immunologically Distinct Vulnerable Populations. Clin Infect Dis. 2022 Aug 15; 75(Supplement_1):S30-S36. PMID: 35512145; PMCID: PMC9129145.
    Citations:    Fields:    
  3. Nanishi E, Angelidou A, Rotman C, Dowling DJ, Levy O, Ozonoff A. Precision Vaccine Adjuvants for Older Adults: A Scoping Review. Clin Infect Dis. 2022 Aug 15; 75(Supplement_1):S72-S80. PMID: 35439286; PMCID: PMC9376277.
    Citations:    Fields:    
  4. Barman S, Soni D, Brook B, Nanishi E, Dowling DJ. Precision Vaccine Development: Cues From Natural Immunity. Front Immunol. 2021; 12:662218. PMID: 35222350; PMCID: PMC8866702.
    Citations:    Fields:    Translation:HumansCells
  5. Borriello F, Poli V, Shrock E, Spreafico R, Liu X, Pishesha N, Carpenet C, Chou J, Di Gioia M, McGrath ME, Dillen CA, Barrett NA, Lacanfora L, Franco ME, Marongiu L, Iwakura Y, Pucci F, Kruppa MD, Ma Z, Lowman DW, Ensley HE, Nanishi E, Saito Y, O'Meara TR, Seo HS, Dhe-Paganon S, Dowling DJ, Frieman M, Elledge SJ, Levy O, Irvine DJ, Ploegh HL, Williams DL, Zanoni I. An adjuvant strategy enabled by modulation of the physical properties of microbial ligands expands antigen immunogenicity. Cell. 2022 02 17; 185(4):614-629.e21. PMID: 35148840; PMCID: PMC8857056.
    Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
  6. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305. PMID: 34783582.
    Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  7. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. PMID: 34031655; PMCID: PMC8142652.
    Citations: 1     
  8. Sanchez-Schmitz G, Morrocchi E, Cooney M, Soni D, Khatun R, Palma P, Dowling DJ, Levy O. Neonatal monocytes demonstrate impaired homeostatic extravasation into a microphysiological human vascular model. Sci Rep. 2020 10 20; 10(1):17836. PMID: 33082466.
    Citations: 4     Fields:    Translation:HumansCells
  9. Soni D, Van Haren SD, Idoko OT, Evans JT, Diray-Arce J, Dowling DJ, Levy O. Towards Precision Vaccines: Lessons From the Second International Precision Vaccines Conference. Front Immunol. 2020; 11:590373. PMID: 33178222.
    Citations: 4     Fields:    Translation:HumansAnimals
  10. Soni D, Bobbala S, Li S, Scott EA, Dowling DJ. The sixth revolution in pediatric vaccinology: immunoengineering and delivery systems. Pediatr Res. 2021 05; 89(6):1364-1372. PMID: 32927471; PMCID: PMC7511675.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  11. Angelidou A, Diray-Arce J, Conti MG, Smolen KK, van Haren SD, Dowling DJ, Husson RN, Levy O. BCG as a Case Study for Precision Vaccine Development: Lessons From Vaccine Heterogeneity, Trained Immunity, and Immune Ontogeny. Front Microbiol. 2020; 11:332. PMID: 32218774; PMCID: PMC7078104.
    Citations: 23     
  12. Sharma P, Levy O, Dowling DJ. The TLR5 Agonist Flagellin Shapes Phenotypical and Functional Activation of Lung Mucosal Antigen Presenting Cells in Neonatal Mice. Front Immunol. 2020; 11:171. PMID: 32132997.
    Citations: 8     Fields:    Translation:AnimalsCellsPHPublic Health
  13. Nanishi E, Dowling DJ, Levy O. Toward precision adjuvants: optimizing science and safety. Curr Opin Pediatr. 2020 02; 32(1):125-138. PMID: 31904601.
    Citations: 20     Fields:    Translation:Humans
  14. Speer EM, Diago-Navarro E, Ozog LS, Dowling DJ, Hou W, Raheel M, Fries BC, Levy O. Pentoxifylline Alone or in Combination with Gentamicin or Vancomycin Inhibits Live Microbe-Induced Proinflammatory Cytokine Production in Human Cord Blood and Cord Blood Monocytes In Vitro. Antimicrob Agents Chemother. 2018 12; 62(12). PMID: 30275087.
    Citations: 4     Fields:    Translation:HumansCells
  15. Queenan AM, Dowling DJ, Cheng WK, Faé K, Fernandez J, Flynn PJ, Joshi S, Brightman SE, Ramirez J, Serroyen J, Wiertsema S, Fortanier A, van den Dobbelsteen G, Levy O, Poolman J. Increasing FIM2/3 antigen-content improves efficacy of Bordetella pertussis vaccines in mice in vivo without altering vaccine-induced human reactogenicity biomarkers in vitro. Vaccine. 2019 01 03; 37(1):80-89. PMID: 30478007.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  16. Dowling DJ. Recent Advances in the Discovery and Delivery of TLR7/8 Agonists as Vaccine Adjuvants. Immunohorizons. 2018 07 02; 2(6):185-197. PMID: 31022686.
    Citations: 48     Fields:    Translation:HumansPHPublic Health
  17. Speer EM, Dowling DJ, Xu J, Ozog LS, Mathew JA, Chander A, Yin D, Levy O. Pentoxifylline, dexamethasone and azithromycin demonstrate distinct age-dependent and synergistic inhibition of TLR- and inflammasome-mediated cytokine production in human newborn and adult blood in vitro. PLoS One. 2018; 13(5):e0196352. PMID: 29715306.
    Citations: 7     Fields:    Translation:HumansCells
  18. Scheid A, Borriello F, Pietrasanta C, Christou H, Diray-Arce J, Pettengill MA, Joshi S, Li N, Bergelson I, Kollmann T, Dowling DJ, Levy O. Adjuvant Effect of Bacille Calmette-Guérin on Hepatitis B Vaccine Immunogenicity in the Preterm and Term Newborn. Front Immunol. 2018; 9:29. PMID: 29416539.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  19. Borriello F, Pietrasanta C, Lai JCY, Walsh LM, Sharma P, O'Driscoll DN, Ramirez J, Brightman S, Pugni L, Mosca F, Burkhart DJ, Dowling DJ, Levy O. Identification and Characterization of Stimulator of Interferon Genes As a Robust Adjuvant Target for Early Life Immunization. Front Immunol. 2017; 8:1772. PMID: 29312305.
    Citations: 16     Fields:    
  20. Dowling DJ, Scott EA, Scheid A, Bergelson I, Joshi S, Pietrasanta C, Brightman S, Sanchez-Schmitz G, Van Haren SD, Ninkovic J, Kats D, Guiducci C, de Titta A, Bonner DK, Hirosue S, Swartz MA, Hubbell JA, Levy O. Toll-like receptor 8 agonist nanoparticles mimic immunomodulating effects of the live BCG vaccine and enhance neonatal innate and adaptive immune responses. J Allergy Clin Immunol. 2017 Nov; 140(5):1339-1350. PMID: 28343701; PMCID: PMC5667586.
    Citations: 52     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  21. Dowling DJ, van Haren SD, Scheid A, Bergelson I, Kim D, Mancuso CJ, Foppen W, Ozonoff A, Fresh L, Theriot TB, Lackner AA, Fichorova RN, Smirnov D, Vasilakos JP, Beaurline JM, Tomai MA, Midkiff CC, Alvarez X, Blanchard JL, Gilbert MH, Aye PP, Levy O. TLR7/8 adjuvant overcomes newborn hyporesponsiveness to pneumococcal conjugate vaccine at birth. JCI Insight. 2017 03 23; 2(6):e91020. PMID: 28352660.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  22. Speer EM, Dowling DJ, Ozog LS, Xu J, Yang J, Kennady G, Levy O. Pentoxifylline inhibits TLR- and inflammasome-mediated in vitro inflammatory cytokine production in human blood with greater efficacy and potency in newborns. Pediatr Res. 2017 May; 81(5):806-816. PMID: 28072760.
    Citations: 16     Fields:    Translation:Humans
  23. Dowling DJ, Sanders H, Cheng WK, Joshi S, Brightman S, Bergelson I, Pietrasanta C, van Haren SD, van Amsterdam S, Fernandez J, van den Dobbelsteen GP, Levy O. A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity. Front Immunol. 2016; 7:562. PMID: 28008331.
    Citations: 11     Fields:    
  24. van Haren SD, Dowling DJ, Foppen W, Christensen D, Andersen P, Reed SG, Hershberg RM, Baden LR, Levy O. Age-Specific Adjuvant Synergy: Dual TLR7/8 and Mincle Activation of Human Newborn Dendritic Cells Enables Th1 Polarization. J Immunol. 2016 12 01; 197(11):4413-4424. PMID: 27793997; PMCID: PMC7386828.
    Citations: 32     Fields:    Translation:HumansCells
  25. Dowling DJ. Early life immune ontogeny - understanding how we build and sustain immunity to infection. Perspect Public Health. 2016 Jul; 136(4):205-7. PMID: 27354502.
    Citations: 3     Fields:    
  26. Pettengill MA, van Haren SD, Li N, Dowling DJ, Bergelson I, Jans J, Ferwerda G, Levy O. Distinct TLR-mediated cytokine production and immunoglobulin secretion in human newborn naïve B cells. Innate Immun. 2016 08; 22(6):433-43. PMID: 27252169.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  27. van Haren SD, Ganapathi L, Bergelson I, Dowling DJ, Banks M, Samuels RC, Reed SG, Marshall JD, Levy O. In vitro cytokine induction by TLR-activating vaccine adjuvants in human blood varies by age and adjuvant. Cytokine. 2016 07; 83:99-109. PMID: 27081760.
    Citations: 21     Fields:    Translation:HumansCellsCTClinical Trials
  28. Oh DY, Dowling DJ, Ahmed S, Choi H, Brightman S, Bergelson I, Berger ST, Sauld JF, Pettengill M, Kho AT, Pollack HJ, Steen H, Levy O. Adjuvant-induced Human Monocyte Secretome Profiles Reveal Adjuvant- and Age-specific Protein Signatures. Mol Cell Proteomics. 2016 06; 15(6):1877-94. PMID: 26933193.
    Citations: 11     Fields:    Translation:HumansCells
  29. Dowling DJ, Levy O. Pediatric Vaccine Adjuvants: Components of the Modern Vaccinologist's Toolbox. Pediatr Infect Dis J. 2015 Dec; 34(12):1395-8. PMID: 26353029; PMCID: PMC4931280.
    Citations: 19     Fields:    Translation:Humans
  30. Ganapathi L, Van Haren S, Dowling DJ, Bergelson I, Shukla NM, Malladi SS, Balakrishna R, Tanji H, Ohto U, Shimizu T, David SA, Levy O. The Imidazoquinoline Toll-Like Receptor-7/8 Agonist Hybrid-2 Potently Induces Cytokine Production by Human Newborn and Adult Leukocytes. PLoS One. 2015; 10(8):e0134640. PMID: 26274907.
    Citations: 21     Fields:    Translation:HumansCells
  31. Palmer CD, Ninkovic J, Prokopowicz ZM, Mancuso CJ, Marin A, Andrianov AK, Dowling DJ, Levy O. The effect of stable macromolecular complexes of ionic polyphosphazene on HIV Gag antigen and on activation of human dendritic cells and presentation to T-cells. Biomaterials. 2014 Oct; 35(31):8876-8886. PMID: 25023392.
    Citations: 18     Fields:    Translation:HumansCells
  32. Dowling DJ, Levy O. Ontogeny of early life immunity. Trends Immunol. 2014 Jul; 35(7):299-310. PMID: 24880460.
    Citations: 144     Fields:    Translation:Humans
  33. Vukman KV, Adams PN, Dowling D, Metz M, Maurer M, O'Neill SM. The effects of Fasciola hepatica tegumental antigens on mast cell function. Int J Parasitol. 2013 Jun; 43(7):531-9. PMID: 23535069.
    Citations: 6     Fields:    Translation:AnimalsCells
  34. Dowling DJ, Tan Z, Prokopowicz ZM, Palmer CD, Matthews MA, Dietsch GN, Hershberg RM, Levy O. The ultra-potent and selective TLR8 agonist VTX-294 activates human newborn and adult leukocytes. PLoS One. 2013; 8(3):e58164. PMID: 23483986.
    Citations: 38     Fields:    Translation:HumansCells
  35. Noone C, Parkinson M, Dowling DJ, Aldridge A, Kirwan P, Molloy SF, Asaolu SO, Holland C, O'Neill SM. Plasma cytokines, chemokines and cellular immune responses in pre-school Nigerian children infected with Plasmodium falciparum. Malar J. 2013 Jan 07; 12:5. PMID: 23294670.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  36. Morphew RM, Hamilton CM, Wright HA, Dowling DJ, O'Neill SM, Brophy PM. Identification of the major proteins of an immune modulating fraction from adult Fasciola hepatica released by Nonidet P40. Vet Parasitol. 2013 Jan 31; 191(3-4):379-85. PMID: 23021260; PMCID: PMC4096658.
    Citations: 7     Fields:    Translation:AnimalsCells
  37. LaCourse EJ, Perally S, Morphew RM, Moxon JV, Prescott M, Dowling DJ, O'Neill SM, Kipar A, Hetzel U, Hoey E, Zafra R, Buffoni L, Pérez Arévalo J, Brophy PM. The Sigma class glutathione transferase from the liver fluke Fasciola hepatica. PLoS Negl Trop Dis. 2012; 6(5):e1666. PMID: 22666515.
    Citations: 25     Fields:    Translation:AnimalsPHPublic Health
  38. Philbin VJ, Dowling DJ, Gallington LC, Cortés G, Tan Z, Suter EE, Chi KW, Shuckett A, Stoler-Barak L, Tomai M, Miller RL, Mansfield K, Levy O. Imidazoquinoline Toll-like receptor 8 agonists activate human newborn monocytes and dendritic cells through adenosine-refractory and caspase-1-dependent pathways. J Allergy Clin Immunol. 2012 Jul; 130(1):195-204.e9. PMID: 22521247; PMCID: PMC3387351.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  39. Dowling DJ, Noone CM, Adams PN, Vukman KV, Molloy SF, Forde J, Asaolu S, O'Neill SM. Ascaris lumbricoides pseudocoelomic body fluid induces a partially activated dendritic cell phenotype with Th2 promoting ability in vivo. Int J Parasitol. 2011 Feb; 41(2):255-61. PMID: 20974144.
    Citations: 7     Fields:    Translation:AnimalsCells
  40. Dowling DJ, Hamilton CM, Donnelly S, La Course J, Brophy PM, Dalton J, O'Neill SM. Major secretory antigens of the helminth Fasciola hepatica activate a suppressive dendritic cell phenotype that attenuates Th17 cells but fails to activate Th2 immune responses. Infect Immun. 2010 Feb; 78(2):793-801. PMID: 19917714.
    Citations: 57     Fields:    Translation:AnimalsCells
  41. Hamilton CM, Dowling DJ, Loscher CE, Morphew RM, Brophy PM, O'Neill SM. The Fasciola hepatica tegumental antigen suppresses dendritic cell maturation and function. Infect Immun. 2009 Jun; 77(6):2488-98. PMID: 19332532.
    Citations: 56     Fields:    Translation:AnimalsCells
  42. Dowling D, Hamilton CM, O'Neill SM. A comparative analysis of cytokine responses, cell surface marker expression and MAPKs in DCs matured with LPS compared with a panel of TLR ligands. Cytokine. 2008 Mar; 41(3):254-62. PMID: 18221884.
    Citations: 25     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.