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David Dowling, Ph.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. 75N93019C00044 (David Dowling) Apr 30, 2022 - Apr 30, 2024
    NIH/NIAID
    Advancement of TLR7/8 Adjuvant Development
    Role Description: This contract supplement supports the development of novel TLR7/8 agonist adjuvants for use in influenza and coronavirus vaccines.
  2. TDF2019 (David Dowling) Jul 30, 2021 - Sep 30, 2023
    Boston Children’s Hospital Technology Development Fund
    Adjuvant optimization via structure-activity relationship studies
    Role Description: This award advances the clinical development of patented adjuvants developed within the Dowling Laboratory.
  3. 75N93020C00038 (David Dowling) Oct 1, 2020 - Sep 30, 2025
    NIH/NIAID
    Development of Vaccines for the Treatment of Opioid Use Disorder
    Role Description: This contract is to develop an effective adjuvanted anti-fentanyl vaccine via the induction of anti-fentanyl antibodies that will block the movement of fentanyl from the bloodstream to the brain where it can suppress respiration and cause death. The production of vaccine formulation pilot lots will be completed under good laboratory practice (GLP) to support Investigational New Drug application (IND)-enabling activities in preparation for chemistry, manufacturing, and control (CMC) process-development and current Good Manufacturing Practice (cGMP) production grade formulation scaled up, to support animal and early-stage Phase I/II safety and immunogenicity human clinical trials in adults and/or youths with opioid use disorder (OUD).
    Role: Principal Investigator
  4. 75N93019C00044 (David Dowling) Apr 30, 2020 - Sep 30, 2022
    NIH/NIAID
    Vaccine Adjuvant Discovery Program - SARS-CoV-2 Vaccine Development
    Role Description: This contract focuses on development of novel adjuvanted SARS-CoV-2 vaccines tailored for use in older humans.
  5. 75N93019C00044 (David Dowling) Oct 1, 2019 - Sep 30, 2024
    NIH/NIAID
    Vaccine Adjuvant Discovery Program
    Role Description: This contract is to discover novel adjuvants for influenza and coronavirus vaccines by screening ~100,000 small molecules for activity towards human leukocytes, including newborn and elderly leukocytes, define mechanisms of action, and develop formulated analogs for in vivo murine and ferret studies.
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.