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Jan Patrick Oscar Schuemann, Ph.D.

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Mentoring
Available: 11/02/20, Expires: 09/30/21

This project is using a Monte Carlo simulation framework to implement and test secondary cancer models on whole body phantoms after radiation therapy. This project will evaluate the importance of the low dose exposure during radiation therapy for potential long term effects (i.e. cancer induction). For this, the phantoms will replace patient CT volumes to allow calculations in low dose areas across the whole body.

The student will use the TOPAS Monte Carlo system (developed in our lab). TOPAS is based on Geant4 and written in C++. Some coding will be required to implement the models and validating the current phantom placement code.

The project can be conducted remotely, on-site studies may be possible. The offices are at in the 125 Nashua St. office building of MGH. The student will meet at least weekly with the mentor to discuss status and problems, but the PI is generally available for Zoom meetings at any day when needed.

Requirements:

  • At least basic C++ knowledge
  • Some shell scripting and/or Python


Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Ramos-Méndez J, Domínguez-Kondo N, Schuemann J, McNamara A, Moreno-Barbosa E, Faddegon B. LET-Dependent Intertrack Yields in Proton Irradiation at Ultra-High Dose Rates Relevant for FLASH Therapy. Radiat Res. 2020 Oct 02; 194(4):351-362. PMID: 32857855.
    Citations:    Fields:    
  2. Stainforth R, Schuemann J, McNamara AL, Wilkins RC, Chauhan V. Challenges in the quantification approach to a radiation relevant adverse outcome pathway for lung cancer. Int J Radiat Biol. 2020 Sep 30; 1-17. PMID: 32909875.
    Citations:    Fields:    
  3. Zhang Q, Cascio E, Li C, Yang Q, Gerweck L, Huang P, Gottschalk B, Flanz J, Schuemann J. FLASH Investigations Using Protons: Design of Delivery System, Preclinical Setup and Confirmation of FLASH Effect with Protons in Animal Systems. Radiat Res. 2020 Sep 29. PMID: 32991708.
    Citations:    Fields:    
  4. Niemierko A, Schuemann J, Niyazi M, Giantsoudi D, Maquilan G, Shih HA, Paganetti H. Brain Necrosis in Adult Patients After Proton Therapy: Is There Evidence for Dependency on Linear Energy Transfer? Int J Radiat Oncol Biol Phys. 2020 Sep 07. PMID: 32911019.
    Citations:    Fields:    
  5. Zhu H, McNamara AL, McMahon SJ, Ramos-Mendez J, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. Cellular Response to Proton Irradiation: A Simulation Study with TOPAS-nBio. Radiat Res. 2020 Jul 08; 194(1):9-21. PMID: 32401689.
    Citations:    Fields:    
  6. Schuemann J, Bagley A, Berbeco R, Bromma K, Butterworth KT, Byrne H, Chithrani DB, Cho SH, Cook JR, Favaudon V, Gholami YH, Gargioni E, Hainfeld JF, Hespeels F, Heuskin AC, Ibeh UM, Kuncic Z, Kunjachan S, Lacombe S, Lucas S, Lux F, McMahon SJ, Nevozhay D, Ngwa W, Payne JD, Penninckx S, Porcel E, Prise KM, Rabus H, Ridwan SM, Rudek B, Sanche L, Singh B, Smilowitz HM, Sokolov KV, Sridhar S, Stanishevskiy Y, Sung W, Tillement O, Virani NA, Yantasee W, Krishnan S. Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions. Phys Med Biol. 2020 May 07. PMID: 32380492.
    Citations: 2     Fields:    
  7. Zhu H, McNamara AL, Ramos-Mendez J, McMahon SJ, Henthorn NT, Faddegon B, Held KD, Perl J, Li J, Paganetti H, Schuemann J. A parameter sensitivity study for simulating DNA damage after proton irradiation using TOPAS-nBio. Phys Med Biol. 2020 04 23; 65(8):085015. PMID: 32101803.
    Citations:    Fields:    Translation:Cells
  8. Faddegon B, Ramos-Méndez J, Schuemann J, McNamara A, Shin J, Perl J, Paganetti H. The TOPAS tool for particle simulation, a Monte Carlo simulation tool for physics, biology and clinical research. Phys Med. 2020 Apr; 72:114-121. PMID: 32247964.
    Citations:    Fields:    
  9. Wang CC, McNamara AL, Shin J, Schuemann J, Grassberger C, Taghian AG, Jimenez RB, MacDonald SM, Paganetti H. End-of-Range Radiobiological Effect on Rib Fractures in Patients Receiving Proton Therapy for Breast Cancer. Int J Radiat Oncol Biol Phys. 2020 Jul 01; 107(3):449-454. PMID: 32240774.
    Citations:    Fields:    
  10. Li WB, Belchior A, Beuve M, Chen YZ, Di Maria S, Friedland W, Gervais B, Heide B, Hocine N, Ipatov A, Klapproth AP, Li CY, Li JL, Multhoff G, Poignant F, Qiu R, Rabus H, Rudek B, Schuemann J, Stangl S, Testa E, Villagrasa C, Xie WZ, Zhang YB. Intercomparison of dose enhancement ratio and secondary electron spectra for gold nanoparticles irradiated by X-rays calculated using multiple Monte Carlo simulation codes. Phys Med. 2020 Jan; 69:147-163. PMID: 31918367.
    Citations: 1     Fields:    
  11. Bannister AH, Bromma K, Sung W, Monica M, Cicon L, Howard P, Chow RL, Schuemann J, Chithrani DB. Modulation of nanoparticle uptake, intracellular distribution, and retention with docetaxel to enhance radiotherapy. Br J Radiol. 2020 Feb 01; 93(1106):20190742. PMID: 31778316.
    Citations: 4     Fields:    Translation:HumansCells
  12. Marteinsdottir M, Schuemann J, Paganetti H. Impact of uncertainties in range and RBE on small field proton therapy. Phys Med Biol. 2019 10 10; 64(20):205005. PMID: 31519016.
    Citations:    Fields:    Translation:Humans
  13. Rudek B, McNamara A, Ramos-Méndez J, Byrne H, Kuncic Z, Schuemann J. Radio-enhancement by gold nanoparticles and their impact on water radiolysis for x-ray, proton and carbon-ion beams. Phys Med Biol. 2019 08 28; 64(17):175005. PMID: 31295730.
    Citations: 1     Fields:    
  14. Abhyankar YS, Dev S, Sarun OS, Saxena A, Joshi R, Darbari H, Sajish C, Sonavane UB, Gavane V, Deshpande A, Dixit T, Harsh R, Badwe R, Rath GK, Laskar S, Faddegon B, Perl J, Paganetti H, Schuemann J, Srivastava A, Obcemea C, Nath AK, Sharma A, Buchsbaum J. Monte Carlo Processing on a Chip (MCoaC)-preliminary experiments toward the realization of optimal-hardware for TOPAS/Geant4 to drive discovery. Phys Med. 2019 Aug; 64:166-173. PMID: 31515016.
    Citations:    Fields:    
  15. Zhu H, Chen Y, Sung W, McNamara AL, Tran LT, Burigo LN, Rosenfeld AB, Li J, Faddegon B, Schuemann J, Paganetti H. The microdosimetric extension in TOPAS: development and comparison with published data. Phys Med Biol. 2019 07 11; 64(14):145004. PMID: 31117056.
    Citations:    Fields:    Translation:Humans
  16. Rieck K, Bromma K, Sung W, Bannister A, Schuemann J, Chithrani DB. Modulation of gold nanoparticle mediated radiation dose enhancement through synchronization of breast tumor cell population. Br J Radiol. 2019 Aug; 92(1100):20190283. PMID: 31219711.
    Citations: 2     Fields:    Translation:HumansCells
  17. Newpower M, Schuemann J, Mohan R, Paganetti H, Titt U. Comparing 2 Monte Carlo Systems in Use for Proton Therapy Research. Int J Part Ther. 2019; 6(1):18-27. PMID: 31773045.
    Citations:    
  18. Schuemann J, McNamara AL, Ramos-Méndez J, Perl J, Held KD, Paganetti H, Incerti S, Faddegon B. TOPAS-nBio: An Extension to the TOPAS Simulation Toolkit for Cellular and Sub-cellular Radiobiology. Radiat Res. 2019 02; 191(2):125-138. PMID: 30609382.
    Citations: 8     Fields:    Translation:HumansCells
  19. Schuemann J, McNamara AL, Warmenhoven JW, Henthorn NT, Kirkby KJ, Merchant MJ, Ingram S, Paganetti H, Held KD, Ramos-Mendez J, Faddegon B, Perl J, Goodhead DT, Plante I, Rabus H, Nettelbeck H, Friedland W, Kundrát P, Ottolenghi A, Baiocco G, Barbieri S, Dingfelder M, Incerti S, Villagrasa C, Bueno M, Bernal MA, Guatelli S, Sakata D, Brown JMC, Francis Z, Kyriakou I, Lampe N, Ballarini F, Carante MP, Davídková M, Štepán V, Jia X, Cucinotta FA, Schulte R, Stewart RD, Carlson DJ, Galer S, Kuncic Z, Lacombe S, Milligan J, Cho SH, Sawakuchi G, Inaniwa T, Sato T, Li W, Solov'yov AV, Surdutovich E, Durante M, Prise KM, McMahon SJ. A New Standard DNA Damage (SDD) Data Format. Radiat Res. 2019 01; 191(1):76-92. PMID: 30407901.
    Citations: 8     Fields:    Translation:Cells
  20. Schuemann J, Bassler N, Inaniwa T. Computational models and tools. Med Phys. 2018 Nov; 45(11):e1073-e1085. PMID: 30421814.
    Citations:    Fields:    Translation:HumansCells
  21. McNamara AL, Ramos-Méndez J, Perl J, Held K, Dominguez N, Moreno E, Henthorn NT, Kirkby KJ, Meylan S, Villagrasa C, Incerti S, Faddegon B, Paganetti H, Schuemann J. Geometrical structures for radiation biology research as implemented in the TOPAS-nBio toolkit. Phys Med Biol. 2018 09 06; 63(17):175018. PMID: 30088810.
    Citations: 3     Fields:    Translation:Humans
  22. Sung W, Jeong Y, Kim H, Jeong H, Grassberger C, Jung S, Ahn GO, Kim IH, Schuemann J, Lee K, Ye SJ. Computational Modeling and Clonogenic Assay for Radioenhancement of Gold Nanoparticles Using 3D Live Cell Images. Radiat Res. 2018 11; 190(5):558-564. PMID: 30142031.
    Citations: 1     Fields:    Translation:HumansCells
  23. Sung W, Schuemann J. Energy optimization in gold nanoparticle enhanced radiation therapy. Phys Med Biol. 2018 06 25; 63(13):135001. PMID: 29873303.
    Citations:    Fields:    Translation:Humans
  24. Yang C, Bromma K, Sung W, Schuemann J, Chithrani D. Determining the Radiation Enhancement Effects of Gold Nanoparticles in Cells in a Combined Treatment with Cisplatin and Radiation at Therapeutic Megavoltage Energies. Cancers (Basel). 2018 May 22; 10(5). PMID: 29786642.
    Citations: 5     
  25. Ramos-Méndez J, Perl J, Schuemann J, McNamara A, Paganetti H, Faddegon B. Monte Carlo simulation of chemistry following radiolysis with TOPAS-nBio. Phys Med Biol. 2018 05 17; 63(10):105014. PMID: 29697057.
    Citations: 5     Fields:    Translation:HumansCells
  26. Meyer J, Stewart RD, Smith D, Eagle J, Lee E, Cao N, Ford E, Hashemian R, Schuemann J, Saini J, Marsh S, Emery R, Dorman E, Schwartz J, Sandison G. Biological and dosimetric characterisation of spatially fractionated proton minibeams. Phys Med Biol. 2017 Nov 21; 62(24):9260-9281. PMID: 29053105.
    Citations: 3     Fields:    
  27. Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu HM, Paganetti H. Time-resolved diode dosimetry calibration through Monte Carlo modeling for in vivo passive scattered proton therapy range verification. J Appl Clin Med Phys. 2017 Nov; 18(6):200-205. PMID: 29082601.
    Citations: 1     Fields:    Translation:Humans
  28. McMahon SJ, McNamara AL, Schuemann J, Paganetti H, Prise KM. A general mechanistic model enables predictions of the biological effectiveness of different qualities of radiation. Sci Rep. 2017 09 07; 7(1):10790. PMID: 28883414.
    Citations: 7     Fields:    Translation:HumansCells
  29. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Correction: Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 08 10; 9(31):11338. PMID: 28758663.
    Citations:    Fields:    
  30. Ramos-Méndez J, Schuemann J, Incerti S, Paganetti H, Schulte R, Faddegon B. Flagged uniform particle splitting for variance reduction in proton and carbon ion track-structure simulations. Phys Med Biol. 2017 Jul 06; 62(15):5908-5925. PMID: 28594336.
    Citations: 2     Fields:    Translation:Humans
  31. Sung W, Ye SJ, McNamara AL, McMahon SJ, Hainfeld J, Shin J, Smilowitz HM, Paganetti H, Schuemann J. Dependence of gold nanoparticle radiosensitization on cell geometry. Nanoscale. 2017 May 11; 9(18):5843-5853. PMID: 28429022.
    Citations: 12     Fields:    
  32. Underwood TS, Sung W, McFadden CH, McMahon SJ, Hall DC, McNamara AL, Paganetti H, Sawakuchi GO, Schuemann J. Comparing stochastic proton interactions simulated using TOPAS-nBio to experimental data from fluorescent nuclear track detectors. Phys Med Biol. 2017 04 21; 62(8):3237-3249. PMID: 28350546.
    Citations: 1     Fields:    Translation:Cells
  33. McNamara A, Geng C, Turner R, Mendez JR, Perl J, Held K, Faddegon B, Paganetti H, Schuemann J. Validation of the radiobiology toolkit TOPAS-nBio in simple DNA geometries. Phys Med. 2017 Jan; 33:207-215. PMID: 28017738.
    Citations: 14     Fields:    Translation:Cells
  34. Geng C, Daartz J, Lam-Tin-Cheung K, Bussiere M, Shih HA, Paganetti H, Schuemann J. Limitations of analytical dose calculations for small field proton radiosurgery. Phys Med Biol. 2017 01 07; 62(1):246-257. PMID: 27991438.
    Citations:    Fields:    Translation:Humans
  35. Qin N, Botas P, Giantsoudi D, Schuemann J, Tian Z, Jiang SB, Paganetti H, Jia X. Recent developments and comprehensive evaluations of a GPU-based Monte Carlo package for proton therapy. Phys Med Biol. 2016 10 21; 61(20):7347-7362. PMID: 27694712.
    Citations: 4     Fields:    
  36. McMahon SJ, Schuemann J, Paganetti H, Prise KM. Mechanistic Modelling of DNA Repair and Cellular Survival Following Radiation-Induced DNA Damage. Sci Rep. 2016 09 14; 6:33290. PMID: 27624453.
    Citations: 10     Fields:    Translation:HumansCells
  37. McNamara AL, Kam WW, Scales N, McMahon SJ, Bennett JW, Byrne HL, Schuemann J, Paganetti H, Banati R, Kuncic Z. Dose enhancement effects to the nucleus and mitochondria from gold nanoparticles in the cytosol. Phys Med Biol. 2016 08 21; 61(16):5993-6010. PMID: 27435339.
    Citations: 9     Fields:    Translation:HumansCells
  38. Oesten H, Loeck S, Helmbrecht S, Tillner F, Wohlfahrt P, Schuemann J, Luehr A. SU-F-T-682: In-Vivo Simulation of the Relative Biological Effectiveness in Proton Therapy Using a Monte Carlo Method. Med Phys. 2016 Jun; 43(6):3621. PMID: 28048410.
    Citations:    
  39. McNamara A, Perl J, Piersimoni P, Ramos-Mendez J, Faddegon B, Held K, Paganetti H, Schuemann J. WE-H-BRA-04: Biological Geometries for the Monte Carlo Simulation Toolkit TOPASNBio. Med Phys. 2016 Jun; 43(6):3843. PMID: 28048349.
    Citations:    
  40. Schuemann J. WE-DE-202-01: Connecting Nanoscale Physics to Initial DNA Damage Through Track Structure Simulations. Med Phys. 2016 Jun; 43(6):3815. PMID: 28047687.
    Citations:    
  41. Abolfath R, Bronk L, Helo Y, Schuemann J, Titt U, Grosshans D, Mohan R. WE-H-BRA-01: BEST IN PHYSICS (THERAPY): Nano-Dosimetric Kinetic Model for Variable Relative Biological Effectiveness of Proton and Ion Beams. Med Phys. 2016 Jun; 43(6):3842. PMID: 28047579.
    Citations:    
  42. Schuemann J. WE-DE-202-00: Connecting Radiation Physics with Computational Biology. Med Phys. 2016 Jun; 43(6):3815. PMID: 28048338.
    Citations:    
  43. Marteinsdottir M, Schuemann J, Paganetti H. WE-AB-207B-06: Dose and Biological Uncertainties in Sarcoma. Med Phys. 2016 Jun; 43(6):3805. PMID: 28047901.
    Citations:    
  44. McMahon S, McNamara A, Schuemann J, Prise K, Paganetti H. WE-H-BRA-07: Mechanistic Modelling of the Relative Biological Effectiveness of Heavy Charged Particles. Med Phys. 2016 Jun; 43(6):3844. PMID: 28046397.
    Citations:    
  45. Hall D, Perl J, Schuemann J, Faddegon B, Paganetti H. SU-F-T-139: Meeting the Challenges of Quality Control in the TOPAS Monte Carlo Simulation Toolkit for Proton Therapy. Med Phys. 2016 Jun; 43(6):3493-3494. PMID: 28047391.
    Citations:    
  46. Underwood T, McFadden C, Trenholm D, Verburg J, Paganetti H, Sawakuchi G, Schuemann J. TH-CD-201-07: Experimentally Investigating Proton Energy Deposition On the Microscopic Scale Using Fluorescence Nuclear Track Detectors. Med Phys. 2016 Jun; 43(6):3870-3871. PMID: 28046465.
    Citations:    
  47. Geng C, Daartz J, Cheung K, Bussiere M, Shih H, Paganetti H, Schuemann J. SU-F-T-157: Physics Considerations Regarding Dosimetric Accuracy of Analytical Dose Calculations for Small Field Proton Therapy: A Monte Carlo Study. Med Phys. 2016 Jun; 43(6):3498. PMID: 28047361.
    Citations:    
  48. Stewart R, Streitmatter S, Traneus E, Moskvin V, Schuemann J. MO-FG-CAMPUS-TeP3-02: Benchmarks of a Proton Relative Biological Effectiveness (RBE) Model for DNA Double Strand Break (DSB) Induction in the FLUKA, MCNP, TOPAS, and RayStation™ Treatment Planning System. Med Phys. 2016 Jun; 43(6):3727-3728. PMID: 28048712.
    Citations:    
  49. Geng C, Moteabbed M, Xie Y, Schuemann J, Yock T, Paganetti H. Assessing the radiation-induced second cancer risk in proton therapy for pediatric brain tumors: the impact of employing a patient-specific aperture in pencil beam scanning. Phys Med Biol. 2016 Jan 07; 61(1):12-22. PMID: 26605679.
    Citations: 3     Fields:    Translation:Humans
  50. Verburg JM, Grassberger C, Dowdell S, Schuemann J, Seco J, Paganetti H. Automated Monte Carlo Simulation of Proton Therapy Treatment Plans. Technol Cancer Res Treat. 2016 12; 15(6):NP35-NP46. PMID: 26596915.
    Citations: 6     Fields:    Translation:Humans
  51. McNamara AL, Schuemann J, Paganetti H. A phenomenological relative biological effectiveness (RBE) model for proton therapy based on all published in vitro cell survival data. Phys Med Biol. 2015 Nov 07; 60(21):8399-416. PMID: 26459756.
    Citations: 34     Fields:    Translation:HumansCells
  52. Lin Y, Paganetti H, McMahon SJ, Schuemann J. Gold nanoparticle induced vasculature damage in radiotherapy: Comparing protons, megavoltage photons, and kilovoltage photons. Med Phys. 2015 Oct; 42(10):5890-902. PMID: 26429263.
    Citations: 9     Fields:    Translation:Humans
  53. Schuemann J, Berbeco R, Chithrani DB, Cho SH, Kumar R, McMahon SJ, Sridhar S, Krishnan S. Roadmap to Clinical Use of Gold Nanoparticles for Radiation Sensitization. Int J Radiat Oncol Biol Phys. 2016 Jan 01; 94(1):189-205. PMID: 26700713.
    Citations: 38     Fields:    Translation:HumansAnimals
  54. Polster L, Schuemann J, Rinaldi I, Burigo L, McNamara AL, Stewart RD, Attili A, Carlson DJ, Sato T, Ramos Méndez J, Faddegon B, Perl J, Paganetti H. Extension of TOPAS for the simulation of proton radiation effects considering molecular and cellular endpoints. Phys Med Biol. 2015 Jul 07; 60(13):5053-70. PMID: 26061666.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  55. Qin N, Giantsoudi D, Tian Z, Schuemann J, Pompos A, Paganetti H, Jiang S, Jia X. SU-E-T-673: Recent Developments and Comprehensive Validations of a GPU-Based Proton Monte Carlo Simulation Package, GPMC. Med Phys. 2015 Jun; 42(6):3491. PMID: 26128337.
    Citations:    
  56. Geng C, Schuemann J, Moteabbed M, Paganetti H. SU-E-T-567: Neutron Dose Equivalent Evaluation for Pencil Beam Scanning Proton Therapy with Apertures. Med Phys. 2015 Jun; 42(6):3466. PMID: 26128233.
    Citations:    
  57. Lin Y, Held K, McMahon S, Paganetti H, Schuemann J. SU-E-T-518: Investigation of Gold Nanoparticle Radiosensitization for Carbon Ion Therapy. Med Phys. 2015 Jun; 42(6):3454. PMID: 26128182.
    Citations:    
  58. Toltz A, Hoesl M, Schuemann J, Seuntjens J, Lu H, Paganetti H. SU-E-T-524: In-Vivo Diode Dosimetry Proton Therapy Range Verification Validation Study for Pediatric CSI. Med Phys. 2015 Jun; 42(6):3455. PMID: 26128185.
    Citations:    
  59. Schuemann J, Giantsoudi D, Grassberger C, Paganetti H. SU-E-T-135: Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Med Phys. 2015 Jun; 42(6):3362. PMID: 26127799.
    Citations:    
  60. Ramos-Mendez J, Perl J, Schuemann J, Shin J, Paganetti H, Faddegon B. SU-E-T-466: Implementation of An Extension Module for Dose Response Models in the TOPAS Monte Carlo Toolkit. Med Phys. 2015 Jun; 42(6):3441. PMID: 26128130.
    Citations:    
  61. Hong X, Gao H, Schuemann J, Paganetti H. SU-E-T-769: T-Test Based Prior Error Estimate and Stopping Criterion for Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2015 Jun; 42(6):3514. PMID: 26128432.
    Citations:    
  62. McNamara A, Schuemann J, Paganetti H. SU-F-BRD-13: A Phenomenological Relative Biological Effectiveness (RBE) Model for Proton Therapy Based On All Published in Vitro Cell Survival Data. Med Phys. 2015 Jun; 42(6):3528. PMID: 26128491.
    Citations:    
  63. McNamara A, McMahon S, Lin Y, Paganetti H, Kuncic Z, Schuemann J. TU-F-CAMPUS-T-04: Using Gold Nanoparticles to Target Mitochondria in Radiation Therapy. Med Phys. 2015 Jun; 42(6):3644. PMID: 26129118.
    Citations:    
  64. Lin Y, McMahon SJ, Paganetti H, Schuemann J. Biological modeling of gold nanoparticle enhanced radiotherapy for proton therapy. Phys Med Biol. 2015 May 21; 60(10):4149-68. PMID: 25953956.
    Citations: 18     Fields:    
  65. Schuemann J, Giantsoudi D, Grassberger C, Moteabbed M, Min CH, Paganetti H. Assessing the Clinical Impact of Approximations in Analytical Dose Calculations for Proton Therapy. Int J Radiat Oncol Biol Phys. 2015 Aug 01; 92(5):1157-1164. PMID: 26025779.
    Citations: 13     Fields:    Translation:Humans
  66. Giantsoudi D, Schuemann J, Jia X, Dowdell S, Jiang S, Paganetti H. Validation of a GPU-based Monte Carlo code (gPMC) for proton radiation therapy: clinical cases study. Phys Med Biol. 2015 Mar 21; 60(6):2257-69. PMID: 25715661.
    Citations: 11     Fields:    Translation:HumansPHPublic Health
  67. Lin Y, McMahon SJ, Scarpelli M, Paganetti H, Schuemann J. Comparing gold nano-particle enhanced radiotherapy with protons, megavoltage photons and kilovoltage photons: a Monte Carlo simulation. Phys Med Biol. 2014 Dec 21; 59(24):7675-89. PMID: 25415297.
    Citations: 22     Fields:    Translation:Humans
  68. Moteabbed M, Schuemann J, Paganetti H. Dosimetric feasibility of real-time MRI-guided proton therapy. Med Phys. 2014 Nov; 41(11):111713. PMID: 25370627.
    Citations: 9     Fields:    Translation:Humans
  69. Abe K, Hayato Y, Iida T, Iyogi K, Kameda J, Koshio Y, Kozuma Y, Marti L, Miura M, Moriyama S, Nakahata M, Nakayama S, Obayashi Y, Sekiya H, Shiozawa M, Suzuki Y, Takeda A, Takenaga Y, Ueno K, Ueshima K, Yamada S, Yokozawa T, Ishihara C, Kaji H, Kajita T, Kaneyuki K, Lee KP, McLachlan T, Okumura K, Shimizu Y, Tanimoto N, Labarga L, Kearns E, Litos M, Raaf JL, Stone JL, Sulak LR, Goldhaber M, Bays K, Kropp WR, Mine S, Regis C, Renshaw A, Smy MB, Sobel HW, Ganezer KS, Hill J, Keig WE, Jang JS, Kim JY, Lim IT, Albert JB, Scholberg K, Walter CW, Wendell R, Wongjirad TM, Ishizuka T, Tasaka S, Learned JG, Matsuno S, Smith SN, Hasegawa T, Ishida T, Ishii T, Kobayashi T, Nakadaira T, Nakamura K, Nishikawa K, Oyama Y, Sakashita K, Sekiguchi T, Tsukamoto T, Suzuki AT, Takeuchi Y, Ikeda M, Minamino A, Nakaya T, Fukuda Y, Itow Y, Mitsuka G, Tanaka T, Jung CK, Lopez GD, Taylor I, Yanagisawa C, Ishino H, Kibayashi A, Mino S, Mori T, Sakuda M, Toyota H, Kuno Y, Yoshida M, Kim SB, Yang BS, Okazawa H, Choi Y, Nishijima K, Koshiba M, Yokoyama M, Totsuka Y, Martens K, Schuemann J, Vagins MR, Chen S, Heng Y, Yang Z, Zhang H, Kielczewska D, Mijakowski P, Connolly K, Dziomba M, Thrane E, Wilkes RJ. Search for nucleon decay via n??[over ¯]p0 and p??[over ¯]p+ in Super-Kamiokande. Phys Rev Lett. 2014 Sep 19; 113(12):121802. PMID: 25279622.
    Citations:    Fields:    
  70. Schuemann J, Dowdell S, Grassberger C, Min CH, Paganetti H. Site-specific range uncertainties caused by dose calculation algorithms for proton therapy. Phys Med Biol. 2014 Aug 07; 59(15):4007-31. PMID: 24990623.
    Citations: 25     Fields:    Translation:Humans
  71. Sterpin E, Sorriaux J, Schuemann J, Souris K, Lee J, Vynckier S, Jia X, Jiang S, Paganetti H. SU-E-T-180: Fano Cavity Test of Proton Transport in Monte Carlo Codes Running On GPU and Xeon Phi. Med Phys. 2014 Jun; 41(6):264. PMID: 28036964.
    Citations:    
  72. Sorriaux J, Paganetti H, Testa M, Giantsoudi D, Schuemann J, Bertrand D, Orban de Xivry J, Lee J, Palmans H, Vynckier S, Sterpin E. SU-E-T-464: On the Equivalence of the Quality Correction Factor for Pencil Beam Scanning Proton Therapy. Med Phys. 2014 Jun; 41(6):333. PMID: 28036486.
    Citations:    
  73. Lin Y, Paganetti H, Schuemann J. WE-G-BRE-04: Gold Nanoparticle Induced Vasculature Damage for Proton Therapy: Monte Carlo Simulation. Med Phys. 2014 Jun; 41(6):517. PMID: 28037669.
    Citations:    
  74. Schuemann J, Dowdell S, Grassberger C, Paganetti H. TH-A-19A-06: Site-Specific Comparison of Analytical and Monte Carlo Based Dose Calculations. Med Phys. 2014 Jun; 41(6):534. PMID: 28037127.
    Citations:    
  75. Schuemann J, Giantsoudi D, Rinaldi I, Perl J, Faddegon B, Paganetti H. TH-A-19A-02: Expanding TOPAS Towards Biological Modeling. Med Phys. 2014 Jun; 41(6):533. PMID: 28037074.
    Citations:    
  76. Dowdell S, Greilich S, Zimmerman F, Evans C, Paganetti H, Schuemann J. WE-D-BRF-01: FEATURED PRESENTATION - Investigating Particle Track Structures Using Fluorescent Nuclear Track Detectors and Monte Carlo Simulations. Med Phys. 2014 Jun; 41(6):495. PMID: 28037271.
    Citations:    
  77. Giantsoudi D, Schuemann J, Dowdell S, Jia X, Jiang S, Paganetti H. TH-A-19A-11: Validation of GPU-Based Monte Carlo Code (gPMC) Versus Fully Implemented Monte Carlo Code (TOPAS) for Proton Radiation Therapy: Clinical Cases Study. Med Phys. 2014 Jun; 41(6):535. PMID: 28038006.
    Citations:    
  78. Lin Y, Paganetti H, Schuemann J. WE-G-BRE-02: Biological Modeling of Gold Nanoparticle Radiosensitization for Proton Therapy. Med Phys. 2014 Jun; 41(6):517. PMID: 28036686.
    Citations:    
  79. Bueno M, Paganetti H, Duch MA, Schuemann J. An algorithm to assess the need for clinical Monte Carlo dose calculation for small proton therapy fields based on quantification of tissue heterogeneity. Med Phys. 2013 Aug; 40(8):081704. PMID: 23927301.
    Citations: 8     Fields:    Translation:Humans
  80. Schuemann J, Testa M, Bueno M, Min C, Moteabbed M, Giantsoudi D, Paganetti H. SU-E-T-451: Patient and Site-Specific Assessment of the Value of Routine Monte Carlo Dose Calculation in Proton Therapy. Med Phys. 2013 Jun; 40(6Part17):309. PMID: 28517710.
    Citations:    
  81. Jia X, Schuemann J, Paganetti H, Jiang S. WE-F-105-03: Development of GPMC V2.0, a GPU-Based Monte Carlo Dose Calculation Package for Proton Radiotherapy. Med Phys. 2013 Jun; 40(6Part30):498. PMID: 28519186.
    Citations:    
  82. Ramos-Mendez J, Perl J, Schuemann J, Shin J, Faddegon B, Paganetti H. WE-C-108-07: Optimal Parameters for Variance Reduction in Monte Carlo Simulations for Proton Therapy. Med Phys. 2013 Jun; 40(6Part28):475. PMID: 28519918.
    Citations:    
  83. Testa M, Min C, Schuemann J, Verburg J, Lu H, Paganetti H. WE-G-500-04: A Novel Technique for In-Vivo and Real-Time Range Verification Based On the Characteristic Prompt Gamma Time-Structure of Passively Modulated Proton Beams. Med Phys. 2013 Jun; 40(6Part30):503. PMID: 28519183.
    Citations:    
  84. Perl J, Shin J, Schuemann J, Paganetti H, Faddegon B. TU-A-108-01: Four-Dimensional Monte Carlo Using the TOPAS TOol for PArticle Simulation. Med Phys. 2013 Jun; 40(6Part25):419. PMID: 28518854.
    Citations:    
  85. Schuemann J, Dowdell S, Barbone G, Paganetti H. SU-E-T-404: Quantification of Proton Dose Enhancement Resulting From Gold Nanoparticles. Med Phys. 2013 Jun; 40(6Part17):297. PMID: 28517700.
    Citations:    
  86. Abe K, Hayato Y, Iida T, Iyogi K, Kameda J, Koshio Y, Kozuma Y, Marti L, Miura M, Moriyama S, Nakahata M, Nakayama S, Obayashi Y, Sekiya H, Shiozawa M, Suzuki Y, Takeda A, Takenaga Y, Ueno K, Ueshima K, Yamada S, Yokozawa T, Ishihara C, Kaji H, Kajita T, Kaneyuki K, Lee KP, McLachlan T, Okumura K, Shimizu Y, Tanimoto N, Labarga L, Kearns E, Litos M, Raaf JL, Stone JL, Sulak LR, Goldhaber M, Bays K, Kropp WR, Mine S, Regis C, Renshaw A, Smy MB, Sobel HW, Ganezer KS, Hill J, Keig WE, Jang JS, Kim JY, Lim IT, Albert JB, Scholberg K, Walter CW, Wendell R, Wongjirad TM, Ishizuka T, Tasaka S, Learned JG, Matsuno S, Smith SN, Hasegawa T, Ishida T, Ishii T, Kobayashi T, Nakadaira T, Nakamura K, Nishikawa K, Oyama Y, Sakashita K, Sekiguchi T, Tsukamoto T, Suzuki AT, Takeuchi Y, Ikeda M, Minamino A, Nakaya T, Fukuda Y, Itow Y, Mitsuka G, Tanaka T, Jung CK, Lopez GD, Taylor I, Yanagisawa C, Ishino H, Kibayashi A, Mino S, Mori T, Sakuda M, Toyota H, Kuno Y, Yoshida M, Kim SB, Yang BS, Okazawa H, Choi Y, Nishijima K, Koshiba M, Yokoyama M, Totsuka Y, Martens K, Schuemann J, Vagins MR, Chen S, Heng Y, Yang Z, Zhang H, Kielczewska D, Mijakowski P, Connolly K, Dziomba M, Thrane E, Wilkes RJ. Evidence for the appearance of atmospheric tau neutrinos in super-Kamiokande. Phys Rev Lett. 2013 May 03; 110(18):181802. PMID: 23683190.
    Citations:    Fields:    
  87. Butterworth KT, McGarry CK, Clasie B, Carabe-Fernandez A, Schuemann J, Depauw N, Tang S, McMahon SJ, Schettino G, O'Sullivan JM, Lu HM, Kooy H, Paganetti H, Hounsell AR, Held KD, Prise KM. Relative biological effectiveness (RBE) and out-of-field cell survival responses to passive scattering and pencil beam scanning proton beam deliveries. Phys Med Biol. 2012 Oct 21; 57(20):6671-80. PMID: 23022765.
    Citations: 2     Fields:    Translation:HumansCells
  88. Moteabbed M, Schuemann J, Paganetti H. SU-E-T-470: Comparison of Proton Treatment Planning and Monte Carlo Calculation Using TOPAS for Liver Cancer. Med Phys. 2012 Jun; 39(6Part17):3813. PMID: 28517462.
    Citations:    Fields:    
  89. Schuemann J, Shin J, Perl J, Grassberger C, Verburg J, Faddegon B, Paganetti H. SU-E-T-500: Pencil-Beam versus Monte Carlo Based Dose Calculation for Proton Therapy Patients with Complex Geometries. Clinical Use of the TOPAS Monte Carlo System. Med Phys. 2012 Jun; 39(6Part18):3820. PMID: 28518479.
    Citations: 3     Fields:    
  90. Perl J, Shin J, Schuemann J, Faddegon B, Paganetti H. SU-E-T-473: Performance Assessment of the TOPAS Tool for Particle Simulation for Proton Therapy Applications. Med Phys. 2012 Jun; 39(6Part17):3814. PMID: 28517451.
    Citations:    Fields:    
  91. Bueno M, Schuemann J, Duch M, Paganetti H. MO-F-BRB-03: A Method to Assess the Need for Clinical Monte Carlo Dose Calculations for Small Proton Therapy Fields. Med Phys. 2012 Jun; 39(6Part21):3874. PMID: 28518244.
    Citations:    Fields:    
  92. Schuemann J. SU-E-T-475: Nano-Dosimetric Track Structure Scoring including Biological Modeling with TOPAS-NBio. Med Phys. 2012 Jun; 39(6Part17):3814. PMID: 28517483.
    Citations: 1     Fields:    
  93. Schümann J, Paganetti H, Shin J, Faddegon B, Perl J. Efficient voxel navigation for proton therapy dose calculation in TOPAS and Geant4. Phys Med Biol. 2012 Jun 07; 57(11):3281-93. PMID: 22572154.
    Citations: 16     Fields:    Translation:Humans
  94. Carabe A, Moteabbed M, Depauw N, Schuemann J, Paganetti H. Range uncertainty in proton therapy due to variable biological effectiveness. Phys Med Biol. 2012 Mar 07; 57(5):1159-72. PMID: 22330133.
    Citations: 23     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.