Harvard Catalyst Profiles

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Emanuela Gussoni, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR069582 (GUSSONI, EMANUELA) Jun 12, 2017 - Feb 28, 2023
    Tetraspanin CD82 in muscle satellite cells quiescence and differentiation
    Role: Principal Investigator
  2. R01AR060317 (GUSSONI, EMANUELA) Jul 15, 2011 - Jun 30, 2017
    Role: Principal Investigator
  3. R01NS047727 (GUSSONI, EMANUELA) Dec 1, 2003 - Apr 30, 2015
    SP cells and downstream progenitors in human and mouse muscle
    Role: Principal Investigator
  4. P01NS040828 (KUNKEL, LOUIS M) Dec 1, 2000 - Mar 31, 2012
    Gene expression in normal &diseased muscle development
    Role: Co-Principal Investigator
  5. P50NS040828 (KUNKEL, LOUIS M) Dec 1, 2000 - Mar 31, 2012
    Pathogenesis and Treatment of Muscular Dystrophy
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wright A, Hall A, Daly T, Fontelonga T, Potter S, Schafer C, Lindsley A, Hung C, Bodamer O, Gussoni E. Lysine methyltransferase 2D regulates muscle fiber size and muscle cell differentiation. FASEB J. 2021 11; 35(11):e21955. PMID: 34613626.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Hall A, Fontelonga T, Wright A, Bugda Gwilt K, Widrick J, Pasut A, Villa F, Miranti CK, Gibbs D, Jiang E, Meng H, Lawlor MW, Gussoni E. Tetraspanin CD82 is necessary for muscle stem cell activation and supports dystrophic muscle function. Skelet Muscle. 2020 11 27; 10(1):34. PMID: 33243288.
    Citations: 1     Fields:    Translation:AnimalsCells
  3. Al Tanoury Z, Rao J, Tassy O, Gobert B, Gapon S, Garnier JM, Wagner E, Hick A, Hall A, Gussoni E, Pourquié O. Differentiation of the human PAX7-positive myogenic precursors/satellite cell lineage in vitro. Development. 2020 06 26; 147(12). PMID: 32541004.
    Citations: 9     Fields:    Translation:HumansCells
  4. Pakula A, Spinazzola JM, Gussoni E. Purification of Myogenic Progenitors from Human Muscle Using Fluorescence-Activated Cell Sorting (FACS). Methods Mol Biol. 2019; 1889:1-15. PMID: 30367405.
    Citations: 4     Fields:    Translation:HumansCells
  5. Parks RJ, Gussoni E. Building immune tolerance through DNA vaccination. Proc Natl Acad Sci U S A. 2018 09 25; 115(39):9652-9654. PMID: 30190431.
    Citations: 1     Fields:    Translation:PHPublic Health
  6. Hung CY, Volkmar B, Baker JD, Bauer JW, Gussoni E, Hainzl S, Klausegger A, Lorenzo J, Mihalek I, Rittinger O, Tekin M, Dallman JE, Bodamer OA. A defect in the inner kinetochore protein CENPT causes a new syndrome of severe growth failure. PLoS One. 2017; 12(12):e0189324. PMID: 29228025.
    Citations: 3     Fields:    Translation:HumansAnimals
  7. Spinazzola JM, Gussoni E. Isolation of Primary Human Skeletal Muscle Cells. Bio Protoc. 2017 Nov 05; 7(21). PMID: 29152538.
    Citations: 8     
  8. Spinazzola JM, Gussoni E. Exosomal Small Talk Carries Strong Messages from Muscle Stem Cells. Cell Stem Cell. 2017 01 05; 20(1):1-3. PMID: 28061348.
    Citations: 4     Fields:    Translation:HumansCells
  9. Alexander MS, Rozkalne A, Colletta A, Spinazzola JM, Johnson S, Rahimov F, Meng H, Lawlor MW, Estrella E, Kunkel LM, Gussoni E. CD82 Is a Marker for Prospective Isolation of Human Muscle Satellite Cells and Is Linked to Muscular Dystrophies. Cell Stem Cell. 2016 12 01; 19(6):800-807. PMID: 27641304.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  10. Chal J, Oginuma M, Al Tanoury Z, Gobert B, Sumara O, Hick A, Bousson F, Zidouni Y, Mursch C, Moncuquet P, Tassy O, Vincent S, Miyanari A, Bera A, Garnier JM, Guevara G, Hestin M, Kennedy L, Hayashi S, Drayton B, Cherrier T, Gayraud-Morel B, Gussoni E, Relaix F, Tajbakhsh S, Pourquié O. Differentiation of pluripotent stem cells to muscle fiber to model Duchenne muscular dystrophy. Nat Biotechnol. 2015 Sep; 33(9):962-9. PMID: 26237517.
    Citations: 153     Fields:    Translation:AnimalsCells
  11. Robin JD, Wright WE, Zou Y, Cossette SC, Lawlor MW, Gussoni E. Isolation and immortalization of patient-derived cell lines from muscle biopsy for disease modeling. J Vis Exp. 2015 Jan 18; (95):52307. PMID: 25651101.
    Citations: 5     Fields:    Translation:HumansCells
  12. Meng H, Janssen PM, Grange RW, Yang L, Beggs AH, Swanson LC, Cossette SA, Frase A, Childers MK, Granzier H, Gussoni E, Lawlor MW. Tissue triage and freezing for models of skeletal muscle disease. J Vis Exp. 2014 Jul 15; (89). PMID: 25078247.
    Citations: 25     Fields:    Translation:AnimalsCells
  13. Di Costanzo S, Balasubramanian A, Pond HL, Rozkalne A, Pantaleoni C, Saredi S, Gupta VA, Sunu CM, Yu TW, Kang PB, Salih MA, Mora M, Gussoni E, Walsh CA, Manzini MC. POMK mutations disrupt muscle development leading to a spectrum of neuromuscular presentations. Hum Mol Genet. 2014 Nov 01; 23(21):5781-92. PMID: 24925318.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  14. Huang P, Schulz TJ, Beauvais A, Tseng YH, Gussoni E. Intramuscular adipogenesis is inhibited by myo-endothelial progenitors with functioning Bmpr1a signalling. Nat Commun. 2014 Jun 05; 5:4063. PMID: 24898859.
    Citations: 18     Fields:    Translation:AnimalsCells
  15. Balasubramanian A, Kawahara G, Gupta VA, Rozkalne A, Beauvais A, Kunkel LM, Gussoni E. Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation. FASEB J. 2014 Jul; 28(7):2955-69. PMID: 24687993.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  16. Rozkalne A, Adkin C, Meng J, Lapan A, Morgan JE, Gussoni E. Mouse regenerating myofibers detected as false-positive donor myofibers with anti-human spectrin. Hum Gene Ther. 2014 Jan; 25(1):73-81. PMID: 24152287.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  17. Wu MP, Doyle JR, Barry B, Beauvais A, Rozkalne A, Piao X, Lawlor MW, Kopin AS, Walsh CA, Gussoni E. G-protein coupled receptor 56 promotes myoblast fusion through serum response factor- and nuclear factor of activated T-cell-mediated signalling but is not essential for muscle development in vivo. FEBS J. 2013 Dec; 280(23):6097-113. PMID: 24102982.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  18. Schulz TJ, Huang P, Huang TL, Xue R, McDougall LE, Townsend KL, Cypess AM, Mishina Y, Gussoni E, Tseng YH. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature. 2013 Mar 21; 495(7441):379-83. PMID: 23485971.
    Citations: 193     Fields:    Translation:AnimalsCells
  19. Lawlor MW, Alexander MS, Viola MG, Meng H, Joubert R, Gupta V, Motohashi N, Manfready RA, Hsu CP, Huang P, Buj-Bello A, Kunkel LM, Beggs AH, Gussoni E. Myotubularin-deficient myoblasts display increased apoptosis, delayed proliferation, and poor cell engraftment. Am J Pathol. 2012 Sep; 181(3):961-8. PMID: 22841819.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  20. Lapan AD, Rozkalne A, Gussoni E. Human fetal skeletal muscle contains a myogenic side population that expresses the melanoma cell-adhesion molecule. Hum Mol Genet. 2012 Aug 15; 21(16):3668-80. PMID: 22634225.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  21. Liadaki K, Casar JC, Wessen M, Luth ES, Jun S, Gussoni E, Kunkel LM. ß4 integrin marks interstitial myogenic progenitor cells in adult murine skeletal muscle. J Histochem Cytochem. 2012 Jan; 60(1):31-44. PMID: 22205679.
    Citations: 13     Fields:    Translation:AnimalsCells
  22. Lapan AD, Gussoni E. Isolation and characterization of human fetal myoblasts. Methods Mol Biol. 2012; 798:3-19. PMID: 22130828.
    Citations: 14     Fields:    Translation:HumansCells
  23. Wu MP, Gussoni E. Carbamylated erythropoietin does not alleviate signs of dystrophy in mdx mice. Muscle Nerve. 2011 Jan; 43(1):88-93. PMID: 21171099.
    Citations: 3     Fields:    Translation:AnimalsCells
  24. Kang PB, Lidov HG, White AJ, Mitchell M, Balasubramanian A, Estrella E, Bennett RR, Darras BT, Shapiro FD, Bambach BJ, Kurtzberg J, Gussoni E, Kunkel LM. Inefficient dystrophin expression after cord blood transplantation in Duchenne muscular dystrophy. Muscle Nerve. 2010 Jun; 41(6):746-50. PMID: 20513101.
    Citations: 7     Fields:    Translation:HumansCells
  25. Sohn RL, Huang P, Kawahara G, Mitchell M, Guyon J, Kalluri R, Kunkel LM, Gussoni E. A role for nephrin, a renal protein, in vertebrate skeletal muscle cell fusion. Proc Natl Acad Sci U S A. 2009 Jun 09; 106(23):9274-9. PMID: 19470472.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  26. Luth ES, Jun SJ, Wessen MK, Liadaki K, Gussoni E, Kunkel LM. Bone marrow side population cells are enriched for progenitors capable of myogenic differentiation. J Cell Sci. 2008 May 01; 121(Pt 9):1426-34. PMID: 18397996.
    Citations: 12     Fields:    Translation:AnimalsCells
  27. Kirillova I, Gussoni E, Goldhamer DJ, Yablonka-Reuveni Z. Myogenic reprogramming of retina-derived cells following their spontaneous fusion with myotubes. Dev Biol. 2007 Nov 15; 311(2):449-63. PMID: 17919536.
    Citations: 17     Fields:    Translation:AnimalsCells
  28. Bruno Peault, Michael Rudnicki, Yvan Torrente, Giulio Cossu, Jacques Tremblay, Terry Partridge, Emanuela Gussoni, Louis M Kunkel and Johnny Huard. Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Molecular Therapy. 2007; 15(5):867-77.
  29. Péault B, Rudnicki M, Torrente Y, Cossu G, Tremblay JP, Partridge T, Gussoni E, Kunkel LM, Huard J. Stem and progenitor cells in skeletal muscle development, maintenance, and therapy. Mol Ther. 2007 May; 15(5):867-77. PMID: 17387336.
    Citations: 223     Fields:    Translation:HumansAnimalsCells
  30. Yoon S, Molloy MJ, Wu MP, Cowan DB, Gussoni E. C6ORF32 is upregulated during muscle cell differentiation and induces the formation of cellular filopodia. Dev Biol. 2007 Jan 01; 301(1):70-81. PMID: 17150207.
    Citations: 22     Fields:    Translation:HumansCells
  31. Frank NY, Kho AT, Schatton T, Murphy GF, Molloy MJ, Zhan Q, Ramoni MF, Frank MH, Kohane IS, Gussoni E. Regulation of myogenic progenitor proliferation in human fetal skeletal muscle by BMP4 and its antagonist Gremlin. J Cell Biol. 2006 Oct 09; 175(1):99-110. PMID: 17015616.
    Citations: 33     Fields:    Translation:HumansCells
  32. Cerletti M, Molloy MJ, Tomczak KK, Yoon S, Ramoni MF, Kho AT, Beggs AH, Gussoni E. Melanoma cell adhesion molecule is a novel marker for human fetal myogenic cells and affects myoblast fusion. J Cell Sci. 2006 Aug 01; 119(Pt 15):3117-27. PMID: 16835268.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  33. Muskiewicz KR, Frank NY, Flint AF, Gussoni E. Myogenic potential of muscle side and main population cells after intravenous injection into sub-lethally irradiated mdx mice. J Histochem Cytochem. 2005 Jul; 53(7):861-73. PMID: 15995145.
    Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
  34. Pavlath GK, Gussoni E. Human myoblasts and muscle-derived SP cells. Methods Mol Med. 2005; 107:97-110. PMID: 15492366.
    Citations: 14     Fields:    Translation:HumansCells
  35. Montanaro F, Liadaki K, Schienda J, Flint A, Gussoni E, Kunkel LM. Demystifying SP cell purification: viability, yield, and phenotype are defined by isolation parameters. Exp Cell Res. 2004 Aug 01; 298(1):144-54. PMID: 15242769.
    Citations: 57     Fields:    Translation:AnimalsCells
  36. Rivier F, Alkan O, Flint AF, Muskiewicz K, Allen PD, Leboulch P, Gussoni E. Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations. J Cell Sci. 2004 Apr 15; 117(Pt 10):1979-88. PMID: 15054107.
    Citations: 14     Fields:    Translation:AnimalsCells
  37. Sohn RL, Gussoni E. Stem cell therapy for muscular dystrophy. Expert Opin Biol Ther. 2004 Jan; 4(1):1-9. PMID: 14680464.
    Citations: 8     Fields:    Translation:HumansAnimals
  38. Sebastiani P, Gussoni E, Kohane I and Ramoni M. Statistical challenges in functional genomics. Statistical Science. 2003; 18:33-70.
  39. Gussoni E, Bennett RR, Muskiewicz KR, Meyerrose T, Nolta JA, Gilgoff I, Stein J, Chan YM, Lidov HG, Bönnemann CG, Von Moers A, Morris GE, Den Dunnen JT, Chamberlain JS, Kunkel LM, Weinberg K. Long-term persistence of donor nuclei in a Duchenne muscular dystrophy patient receiving bone marrow transplantation. J Clin Invest. 2002 Sep; 110(6):807-14. PMID: 12235112.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  40. O'Brien K, Muskiewicz K, Gussoni E. Recent advances in and therapeutic potential of muscle-derived stem cells. J Cell Biochem Suppl. 2002; 38:80-7. PMID: 12046854.
    Citations:    Fields:    Translation:HumansAnimalsCells
  41. Rivier F, Gussoni E. Muscular dystrophies and stem cells: a therapeutic challenge. Cytotherapy. 2002; 4(6):513-9. PMID: 12568986.
    Citations:    Fields:    Translation:HumansAnimals
  42. Gussoni E, Panzara MA, Steinman L. Evaluating human T cell receptor gene expression by PCR. Curr Protoc Immunol. 2001 May; Chapter 10:Unit 10.26. PMID: 18432691.
    Citations:    Fields:    Translation:HumansCells
  43. Panzara MA, Gussoni E, Begovich AB, Murray RS, Zang YQ, Appel SH, Steinman L, Zhang J. T cell receptor BV gene rearrangements in the spinal cords and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. Neurobiol Dis. 1999 Oct; 6(5):392-405. PMID: 10527806.
    Citations: 5     Fields:    Translation:HumansCells
  44. Gussoni E, Soneoka Y, Strickland CD, Buzney EA, Khan MK, Flint AF, Kunkel LM, Mulligan RC. Dystrophin expression in the mdx mouse restored by stem cell transplantation. Nature. 1999 Sep 23; 401(6751):390-4. PMID: 10517639.
    Citations: 385     Fields:    Translation:AnimalsCells
  45. Gussoni E, Blau HM, Kunkel LM. The fate of individual myoblasts after transplantation into muscles of DMD patients. Nat Med. 1997 Sep; 3(9):970-7. PMID: 9288722.
    Citations: 87     Fields:    Translation:HumansCellsCTClinical Trials
  46. Miller RG, Sharma KR, Pavlath GK, Gussoni E, Mynhier M, Lanctot AM, Greco CM, Steinman L, Blau HM. Myoblast implantation in Duchenne muscular dystrophy: the San Francisco study. Muscle Nerve. 1997 Apr; 20(4):469-78. PMID: 9121505.
    Citations: 57     Fields:    Translation:HumansCellsCTClinical Trials
  47. Gussoni E, Panzara MA, Steinman L. Evaluating T-cell receptor gene expression by PCR. Current Protocols in Immunology. 1997; 10.26.1-10.26.14.
  48. Gussoni E, Wang Y, Fraefel C, Miller RG, Blau HM, Geller AI, Kunkel LM. A method to codetect introduced genes and their products in gene therapy protocols. Nat Biotechnol. 1996 Aug; 14(8):1012-6. PMID: 9631042.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  49. Ahn AH, Freener CA, Gussoni E, Yoshida M, Ozawa E, Kunkel LM. The three human syntrophin genes are expressed in diverse tissues, have distinct chromosomal locations, and each bind to dystrophin and its relatives. J Biol Chem. 1996 Feb 02; 271(5):2724-30. PMID: 8576247.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  50. Noguchi S, McNally EM, Ben Othmane K, Hagiwara Y, Mizuno Y, Yoshida M, Yamamoto H, Bönnemann CG, Gussoni E, Denton PH, Kyriakides T, Middleton L, Hentati F, Ben Hamida M, Nonaka I, Vance JM, Kunkel LM, Ozawa E. Mutations in the dystrophin-associated protein gamma-sarcoglycan in chromosome 13 muscular dystrophy. Science. 1995 Nov 03; 270(5237):819-22. PMID: 7481775.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  51. Bönnemann CG, Modi R, Noguchi S, Mizuno Y, Yoshida M, Gussoni E, McNally EM, Duggan DJ, Angelini C, Hoffman EP. Beta-sarcoglycan (A3b) mutations cause autosomal recessive muscular dystrophy with loss of the sarcoglycan complex. Nat Genet. 1995 Nov; 11(3):266-73. PMID: 7581449.
    Citations: 106     Fields:    Translation:HumansAnimalsCells
  52. Gussoni E, Pavlath GK, Miller RG, Panzara MA, Powell M, Blau HM, Steinman L. Specific T cell receptor gene rearrangements at the site of muscle degeneration in Duchenne muscular dystrophy. J Immunol. 1994 Nov 15; 153(10):4798-805. PMID: 7963545.
    Citations: 30     Fields:    Translation:HumansCells
  53. Mora M, Morandi L, Piccinelli A, Gussoni E, Gebbia M, Blasevich F, Dworzak F, Cornelio F. Dystrophin abnormalities in Duchenne and Becker dystrophy carriers: correlation with cytoskeletal proteins and myosins. J Neurol. 1993 Sep; 240(8):455-61. PMID: 8263549.
    Citations:    Fields:    Translation:Humans
  54. Panzara MA, Gussoni E, Steinman L, Oksenberg JR. Analysis of the T cell repertoire using the PCR and specific oligonucleotide primers. Biotechniques. 1992 May; 12(5):728-35. PMID: 1515141.
    Citations: 14     Fields:    Translation:HumansCells
  55. Gussoni E, Pavlath GK, Lanctot AM, Sharma KR, Miller RG, Steinman L, Blau HM. Normal dystrophin transcripts detected in Duchenne muscular dystrophy patients after myoblast transplantation. Nature. 1992 Apr 02; 356(6368):435-8. PMID: 1557125.
    Citations: 86     Fields:    Translation:HumansCells
  56. Morandi L, Mora M, Gussoni E, Tedeschi S, Cornelio F. Dystrophin analysis in Duchenne and Becker muscular dystrophy carriers: correlation with intracellular calcium and albumin. Ann Neurol. 1990 Nov; 28(5):674-9. PMID: 1979724.
    Citations: 10     Fields:    Translation:Humans
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.