Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Emiri T Mandeville, Ph.D., M.D.

Title
Institution
Department
Address

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Shin P, Pian Q, Ishikawa H, Hamanaka G, Mandeville ET, Shuzhen G, Buyin F, Alfadhel M, Allu SR, Sencan-Egilmez I, Li B, Ran C, Vinogradov SA, Ayata C, Lo EH, Arai K, Devor A, Sakadžic S. Aerobic exercise reverses aging-induced depth-dependent decline in cerebral microcirculation. bioRxiv. 2023 Feb 13. PMID: 36824939; PMCID: PMC9949059.
    Citations:    
  2. Li W, Mandeville ET, Durán-Laforet V, Fukuda N, Yu Z, Zheng Y, Held A, Park JH, Nakano T, Tanaka M, Shi J, Esposito E, Niu W, Xing C, Hayakawa K, Lizasoain I, van Leyen K, Ji X, Wainger BJ, Moro MA, Lo EH. Endothelial cells regulate astrocyte to neural progenitor cell trans-differentiation in a mouse model of stroke. Nat Commun. 2022 12 19; 13(1):7812. PMID: 36535938; PMCID: PMC9763251.
    Citations:    Fields:    Translation:AnimalsCells
  3. Esposito E, Zhang F, Park JH, Mandeville ET, Li W, Cuartero MI, Lizasoaín I, Moro MA, Lo EH. Diurnal Differences in Immune Response in Brain, Blood and Spleen After Focal Cerebral Ischemia in Mice. Stroke. 2022 12; 53(12):e507-e511. PMID: 36321457.
    Citations: 3     Fields:    Translation:Animals
  4. Mandeville ET, Li W, Quinto-Alemany D, Zhang F, Esposito E, Nakano T, Mandeville JB, Lee J, Park JH, Arai K, Waeber C, Lizasoain I, Moro MÁ, Lo EH. Fingolimod Does Not Reduce Infarction After Focal Cerebral Ischemia in Mice During Active or Inactive Circadian Phases. Stroke. 2022 12; 53(12):3741-3750. PMID: 36252110.
    Citations:    Fields:    Translation:Animals
  5. Takase H, Hamanaka G, Ohtomo R, Ishikawa H, Chung KK, Mandeville ET, Lok J, Fornage M, Herrup K, Tse KH, Lo EH, Arai K. Transcriptome Profiling of Mouse Corpus Callosum After Cerebral Hypoperfusion. Front Cell Dev Biol. 2021; 9:685261. PMID: 34222254; PMCID: PMC8248229.
    Citations: 1     
  6. Lo EH, Albers GW, Dichgans M, Donnan G, Esposito E, Foster R, Howells DW, Huang YG, Ji X, Klerman EB, Lee S, Li W, Liebeskind DS, Lizasoain I, Mandeville ET, Moro MA, Ning M, Ray D, Sakadžic S, Saver JL, Scheer FAJL, Selim M, Tiedt S, Zhang F, Buchan AM. Circadian Biology and Stroke. Stroke. 2021 06; 52(6):2180-2190. PMID: 33940951.
    Citations: 2     Fields:    Translation:HumansAnimals
  7. Shindo A, Takase H, Hamanaka G, Chung KK, Mandeville ET, Egawa N, Maki T, Borlongan M, Takahashi R, Lok J, Tomimoto H, Lo EH, Arai K. Biphasic roles of pentraxin 3 in cerebrovascular function after white matter stroke. CNS Neurosci Ther. 2021 01; 27(1):60-70. PMID: 33314664; PMCID: PMC7804900.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Seo JH, Maki T, Miyamoto N, Choi YK, Chung KK, Hamanaka G, Park JH, Mandeville ET, Takase H, Hayakawa K, Lok J, Gelman IH, Kim KW, Lo EH, Arai K. AKAP12 Supports Blood-Brain Barrier Integrity against Ischemic Stroke. Int J Mol Sci. 2020 Nov 28; 21(23). PMID: 33260683; PMCID: PMC7730430.
    Citations: 4     Fields:    Translation:Animals
  9. Esposito E, Li W, Mandeville ET, Park JH, Sencan I, Guo S, Shi J, Lan J, Lee J, Hayakawa K, Sakadžic S, Ji X, Lo EH. Author Correction: Potential circadian effects on translational failure for neuroprotection. Nature. 2020 Jul; 583(7814):E14. PMID: 32533095.
    Citations:    Fields:    
  10. Deng W, Mandeville E, Terasaki Y, Li W, Holder J, Chuang AT, Ning M, Arai K, Lo EH, Xing C. Transcriptomic characterization of microglia activation in a rat model of ischemic stroke. J Cereb Blood Flow Metab. 2020 12; 40(1_suppl):S34-S48. PMID: 33208001.
    Citations: 16     Fields:    Translation:AnimalsCells
  11. Esposito E, Ahn BJ, Shi J, Nakamura Y, Park JH, Mandeville ET, Yu Z, Chan SJ, Desai R, Hayakawa A, Ji X, Lo EH, Hayakawa K. Brain-to-cervical lymph node signaling after stroke. Nat Commun. 2019 11 22; 10(1):5306. PMID: 31757960; PMCID: PMC6876639.
    Citations: 23     Fields:    Translation:AnimalsCells
  12. Lim TC, Mandeville E, Weng D, Wang LS, Kurisawa M, Leite-Morris K, Selim MH, Lo EH, Spector M. Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage. Transl Stroke Res. 2020 06; 11(3):412-417. PMID: 31432328.
    Citations: 9     Fields:    Translation:Animals
  13. Hayakawa K, Chan SJ, Mandeville ET, Park JH, Bruzzese M, Montaner J, Arai K, Rosell A, Lo EH. Protective Effects of Endothelial Progenitor Cell-Derived Extracellular Mitochondria in Brain Endothelium. Stem Cells. 2018 09; 36(9):1404-1410. PMID: 29781122; PMCID: PMC6407639.
    Citations: 46     Fields:    Translation:HumansCells
  14. Cooley CZ, Mandeville JB, Mason EE, Mandeville ET, Wald LL. Rodent Cerebral Blood Volume (CBV) changes during hypercapnia observed using Magnetic Particle Imaging (MPI) detection. Neuroimage. 2018 09; 178:713-720. PMID: 29738908.
    Citations: 10     Fields:    Translation:Animals
  15. Lu D, Jiang Y, Ji Y, Zhou IY, Mandeville E, Lo EH, Wang X, Sun PZ. JOURNAL CLUB: Evaluation of Diffusion Kurtosis Imaging of Stroke Lesion With Hemodynamic and Metabolic MRI in a Rodent Model of Acute Stroke. AJR Am J Roentgenol. 2018 Apr; 210(4):720-727. PMID: 29470156; PMCID: PMC6814247.
    Citations: 7     Fields:    Translation:Animals
  16. Maki T, Choi YK, Miyamoto N, Shindo A, Liang AC, Ahn BJ, Mandeville ET, Kaji S, Itoh K, Seo JH, Gelman IH, Lok J, Takahashi R, Kim KW, Lo EH, Arai K. A-Kinase Anchor Protein 12 Is Required for Oligodendrocyte Differentiation in Adult White Matter. Stem Cells. 2018 05; 36(5):751-760. PMID: 29314444.
    Citations: 17     Fields:    Translation:AnimalsCells
  17. Yang S, Gu C, Mandeville ET, Dong Y, Esposito E, Zhang Y, Yang G, Shen Y, Fu X, Lo EH, Xie Z. Anesthesia and Surgery Impair Blood-Brain Barrier and Cognitive Function in Mice. Front Immunol. 2017; 8:902. PMID: 28848542.
    Citations: 59     Fields:    
  18. Zhou IY, Guo Y, Igarashi T, Wang Y, Mandeville E, Chan ST, Wen L, Vangel M, Lo EH, Ji X, Sun PZ. Fast diffusion kurtosis imaging (DKI) with Inherent COrrelation-based Normalization (ICON) enhances automatic segmentation of heterogeneous diffusion MRI lesion in acute stroke. NMR Biomed. 2016 12; 29(12):1670-1677. PMID: 27696558.
    Citations: 6     Fields:    Translation:Animals
  19. Choi YK, Maki T, Mandeville ET, Koh SH, Hayakawa K, Arai K, Kim YM, Whalen MJ, Xing C, Wang X, Kim KW, Lo EH. Dual effects of carbon monoxide on pericytes and neurogenesis in traumatic brain injury. Nat Med. 2016 11; 22(11):1335-1341. PMID: 27668935.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  20. Mandeville ET, Ayata C, Zheng Y, Mandeville JB. Translational MR Neuroimaging of Stroke and Recovery. Transl Stroke Res. 2017 02; 8(1):22-32. PMID: 27578048; PMCID: PMC5243530.
    Citations: 21     Fields:    Translation:HumansAnimals
  21. Fujiwara N, Som AT, Pham LD, Lee BJ, Mandeville ET, Lo EH, Arai K. A free radical scavenger edaravone suppresses systemic inflammatory responses in a rat transient focal ischemia model. Neurosci Lett. 2016 10 28; 633:7-13. PMID: 27589890; PMCID: PMC5324974.
    Citations: 17     Fields:    Translation:AnimalsCells
  22. Guo Y, Zhou IY, Chan ST, Wang Y, Mandeville ET, Igarashi T, Lo EH, Ji X, Sun PZ. pH-sensitive MRI demarcates graded tissue acidification during acute stroke - pH specificity enhancement with magnetization transfer and relaxation-normalized amide proton transfer (APT) MRI. Neuroimage. 2016 Nov 01; 141:242-249. PMID: 27444569.
    Citations: 32     Fields:    Translation:Animals
  23. Shindo A, Maki T, Mandeville ET, Liang AC, Egawa N, Itoh K, Itoh N, Borlongan M, Holder JC, Chuang TT, McNeish JD, Tomimoto H, Lok J, Lo EH, Arai K. Astrocyte-Derived Pentraxin 3 Supports Blood-Brain Barrier Integrity Under Acute Phase of Stroke. Stroke. 2016 Apr; 47(4):1094-100. PMID: 26965847.
    Citations: 51     Fields:    Translation:AnimalsCells
  24. Liang AC, Mandeville ET, Maki T, Shindo A, Som AT, Egawa N, Itoh K, Chuang TT, McNeish JD, Holder JC, Lok J, Lo EH, Arai K. Effects of Aging on Neural Stem/Progenitor Cells and Oligodendrocyte Precursor Cells After Focal Cerebral Ischemia in Spontaneously Hypertensive Rats. Cell Transplant. 2016; 25(4):705-14. PMID: 26811151.
    Citations: 9     Fields:    Translation:AnimalsCells
  25. Lin H, Fang H, Wang J, Meng Q, Dai X, Wu S, Luo J, Pu D, Chen L, Minick D, Arai K, Mandeville ET, Lo E, Holder JC, Chuang TT, Zhao J. Discovery of a novel 2,3,11,11a-tetrahydro-1H-pyrazino[1,2-b]isoquinoline-1,4(6H)-dione series promoting neurogenesis of human neural progenitor cells. Bioorg Med Chem Lett. 2015 Sep 01; 25(17):3748-53. PMID: 26142946.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  26. Gagnon L, Sakadžic S, Lesage F, Mandeville ET, Fang Q, Yaseen MA, Boas DA. Multimodal reconstruction of microvascular-flow distributions using combined two-photon microscopy and Doppler optical coherence tomography. Neurophotonics. 2015 Jan; 2(1):015008. PMID: 26157987; PMCID: PMC4478873.
    Citations: 13     
  27. Gagnon L, Sakadžic S, Lesage F, Musacchia JJ, Lefebvre J, Fang Q, Yücel MA, Evans KC, Mandeville ET, Cohen-Adad J, Polimeni JR, Yaseen MA, Lo EH, Greve DN, Buxton RB, Dale AM, Devor A, Boas DA. Quantifying the microvascular origin of BOLD-fMRI from first principles with two-photon microscopy and an oxygen-sensitive nanoprobe. J Neurosci. 2015 Feb 25; 35(8):3663-75. PMID: 25716864; PMCID: PMC4339366.
    Citations: 90     Fields:    Translation:HumansAnimals
  28. Sakadžic S, Mandeville ET, Gagnon L, Musacchia JJ, Yaseen MA, Yucel MA, Lefebvre J, Lesage F, Dale AM, Eikermann-Haerter K, Ayata C, Srinivasan VJ, Lo EH, Devor A, Boas DA. Large arteriolar component of oxygen delivery implies a safe margin of oxygen supply to cerebral tissue. Nat Commun. 2014 Dec 08; 5:5734. PMID: 25483924.
    Citations: 86     Fields:    Translation:AnimalsCells
  29. Sun PZ, Wang Y, Mandeville E, Chan ST, Lo EH, Ji X. Validation of fast diffusion kurtosis MRI for imaging acute ischemia in a rodent model of stroke. NMR Biomed. 2014 Nov; 27(11):1413-8. PMID: 25208309.
    Citations: 21     Fields:    Translation:Animals
  30. Xing C, Wang X, Cheng C, Montaner J, Mandeville E, Leung W, van Leyen K, Lok J, Wang X, Lo EH. Neuronal production of lipocalin-2 as a help-me signal for glial activation. Stroke. 2014 Jul; 45(7):2085-92. PMID: 24916903.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  31. Wang X, Fan X, Yu Z, Liao Z, Zhao J, Mandeville E, Guo S, Lo EH, Wang X. Effects of tissue plasminogen activator and annexin A2 combination therapy on long-term neurological outcomes of rat focal embolic stroke. Stroke. 2014 Feb; 45(2):619-22. PMID: 24368559.
    Citations: 12     Fields:    Translation:Animals
  32. Esposito E, Mandeville ET, Lo EH. Lower doses of isoflurane treatment has no beneficial effects in a rat model of intracerebral hemorrhage. BMC Neurosci. 2013 Oct 20; 14:129. PMID: 24138708.
    Citations: 5     Fields:    Translation:Animals
  33. Miyamoto N, Maki T, Pham LD, Hayakawa K, Seo JH, Mandeville ET, Mandeville JB, Kim KW, Lo EH, Arai K. Oxidative stress interferes with white matter renewal after prolonged cerebral hypoperfusion in mice. Stroke. 2013 Dec; 44(12):3516-21. PMID: 24072001.
    Citations: 66     Fields:    Translation:AnimalsCells
  34. Li Q, Atochin D, Kashiwagi S, Earle J, Wang A, Mandeville E, Hayakawa K, d'Uscio LV, Lo EH, Katusic Z, Sessa W, Huang PL. Deficient eNOS phosphorylation is a mechanism for diabetic vascular dysfunction contributing to increased stroke size. Stroke. 2013 Nov; 44(11):3183-8. PMID: 23988642.
    Citations: 25     Fields:    Translation:AnimalsCells
  35. Esposito E, Mandeville ET, Hayakawa K, Singhal AB, Lo EH. Effects of normobaric oxygen on the progression of focal cerebral ischemia in rats. Exp Neurol. 2013 Nov; 249:33-8. PMID: 23958492.
    Citations: 17     Fields:    Translation:Animals
  36. Srinivasan VJ, Mandeville ET, Can A, Blasi F, Climov M, Daneshmand A, Lee JH, Yu E, Radhakrishnan H, Lo EH, Sakadžic S, Eikermann-Haerter K, Ayata C. Multiparametric, longitudinal optical coherence tomography imaging reveals acute injury and chronic recovery in experimental ischemic stroke. PLoS One. 2013; 8(8):e71478. PMID: 23940761.
    Citations: 40     Fields:    Translation:Animals
  37. Foerch C, Rosidi NL, Schlunk F, Lauer A, Cianchetti FA, Mandeville E, Arai K, Yigitkanli K, Fan X, Wang X, van Leyen K, Steinmetz H, Schaffer CB, Lo EH. Intravenous tPA therapy does not worsen acute intracerebral hemorrhage in mice. PLoS One. 2013; 8(2):e54203. PMID: 23408937.
    Citations: 7     Fields:    Translation:Animals
  38. Esipova TV, Ye X, Collins JE, Sakadžic S, Mandeville ET, Murray CB, Vinogradov SA. Dendritic upconverting nanoparticles enable in vivo multiphoton microscopy with low-power continuous wave sources. Proc Natl Acad Sci U S A. 2012 Dec 18; 109(51):20826-31. PMID: 23213211.
    Citations: 15     Fields:    Translation:AnimalsCells
  39. Yigitkanli K, Pekcec A, Karatas H, Pallast S, Mandeville E, Joshi N, Smirnova N, Gazaryan I, Ratan RR, Witztum JL, Montaner J, Holman TR, Lo EH, van Leyen K. Inhibition of 12/15-lipoxygenase as therapeutic strategy to treat stroke. Ann Neurol. 2013 Jan; 73(1):129-35. PMID: 23192915.
    Citations: 59     Fields:    Translation:HumansAnimals
  40. Goergen CJ, Radhakrishnan H, Sakadžic S, Mandeville ET, Lo EH, Sosnovik DE, Srinivasan VJ. Optical coherence tractography using intrinsic contrast. Opt Lett. 2012 Sep 15; 37(18):3882-4. PMID: 23041891.
    Citations: 25     Fields:    Translation:AnimalsCells
  41. Srinivasan VJ, Radhakrishnan H, Lo EH, Mandeville ET, Jiang JY, Barry S, Cable AE. OCT methods for capillary velocimetry. Biomed Opt Express. 2012 Mar 01; 3(3):612-29. PMID: 22435106.
    Citations: 63     
  42. Cheung JS, Wang E, Zhang X, Mandeville E, Lo EH, Sorensen AG, Sun PZ. Fast radio-frequency enforced steady state (FRESS) spin echo MRI for quantitative T2 mapping: minimizing the apparent repetition time (TR) dependence for fast T2 measurement. NMR Biomed. 2012 Feb; 25(2):189-94. PMID: 21755552.
    Citations: 9     Fields:    Translation:Animals
  43. Sakadžic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Wu W, Devor A, Lo EH, Vinogradov SA, Boas DA. Cerebral blood oxygenation measurement based on oxygen-dependent quenching of phosphorescence. J Vis Exp. 2011 May 04; (51). PMID: 21587157.
    Citations: 12     Fields:    Translation:Animals
  44. Fujiwara N, Mandeville ET, Geng X, Luo Y, Arai K, Wang X, Ji X, Singhal AB, Lo EH. Effect of normobaric oxygen therapy in a rat model of intracerebral hemorrhage. Stroke. 2011 May; 42(5):1469-72. PMID: 21415401.
    Citations: 6     Fields:    Translation:Animals
  45. Sakadzic S, Roussakis E, Yaseen MA, Mandeville ET, Srinivasan VJ, Arai K, Ruvinskaya S, Devor A, Lo EH, Vinogradov SA, Boas DA. Two-photon high-resolution measurement of partial pressure of oxygen in cerebral vasculature and tissue. Nat Methods. 2010 Sep; 7(9):755-9. PMID: 20693997.
    Citations: 156     Fields:    Translation:Animals
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact contactcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Mandeville's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (211)
Explore
_
Co-Authors (35)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.