John M Asara, Ph.D.
|Title||Associate Professor of Medicine|
|Institution||Beth Israel Deaconess Medical Center|
|Address||Center for Life Science|
BIDMC - Rm 409
3 Blackfan Circle
Boston MA 02115
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|Brandeis University, Waltham, MA||BA||05/1995||Chemistry|
|Michigan State University, East Lansing, MI||Ph.D.||12/1999||Analytical Chemistry|
|Harvard University, Cambridge, MA||PostDoc||04/2002||Proteomics|
|2007||10 out of 100 Top Scientific Discoveries|
|2009||Young Investigator Award|
|2010||Faculty of 1000, Biology, Signal Transduction|
|2010||Outstanding Poster Award|
|2012||Shared Instrumentation Grant Award|
|2014||Capital Equipment Award|
|2015||Academic Partnership Award|
Research activities in the Asara lab focusses on the development of merging tri-omics (proteomics, metabolomics and lipidomics) data. We apply these methods for a personalized medicine approach by analyzing cancer cells and tumor samples in order help make appropriate therapeutic decisions with "smart" drugs. This is accomplished by understanding how cancer cells are signaling for growth and proliferation and how signaling talks to metabolic processes in order to develop mass spec quantitative assays. We are developing hypothesis directed proteomics and gloabl metabolomics and lipidomics strategies to understand the fundamental drivers of disease in cancers such as multiple myeloma, lung cancer and prostate cancer by performing protein-protein interaction studies, immunoprecipitation (IP)-tandem mass spectrometry (MS/MS), quantitative phosphoproteomics, metabolic and lipidomic profiling as well as metabolic flux analyses. Taken together, this information is vital in selecting the appropriate use of newly developed drugs. In addition to our internal research, we are involved in many collaborative projects that are coordinated through our state-of-the-art high resolution mass spectrometry technologies and services through our mass spectrometry facility.
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S10OD010612 (ASARA, JOHN M)May 1, 2012 - Apr 30, 2013NIH
High Resolution Mass Spectrometry System
Role: Principal Investigator
P01CA120964 (KWIATKOWSKI, DAVID J.)Apr 1, 2006 - Jul 31, 2017NIH/NCI
Molecular Pathogenesis of the Hamartoma Syndromes
Role: Co-Principal Investigator
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