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profileKoichi Yuki, M.D.

TitleAssociate Professor of Anaesthesia
InstitutionBoston Children's Hospital
DepartmentAnaesthesia
AddressChildrens Hospital
Div of Cardiac Anesthesia
300 Longwood Ave
Boston MA 02115
Phone617/355-6225
Fax617/730-0799
vCardDownload vCard (login for email)

Collapse Research 
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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01GM118277     (YUKI, KOICHI)Apr 1, 2016 - Mar 31, 2021
NIH/NIGMS
The impact of anesthetic selection on sepsis outcome and its mechanism
Role: Principal Investigator

K08GM101345     (YUKI, KOICHI)Apr 1, 2012 - Mar 31, 2017
NIH/NIGMS
Immunomodulatory mechanism of volatile anesthetics
Role: Principal Investigator

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Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Koutsogiannaki S, Schaefers MM, Okuno T, Ohba M, Yokomizo T, Priebe GP, DiNardo JA, Sulpicio SG, Yuki K. From the Cover: Prolonged Exposure to Volatile Anesthetic Isoflurane Worsens the Outcome of Polymicrobial Abdominal Sepsis. Toxicol Sci. 2017 Apr 01; 156(2):402-411. PMID: 28003439.
    View in: PubMed
  2. Ferradal SL, Yuki K, Vyas R, Ha CG, Yi F, Stopp C, Wypij D, Cheng HH, Newburger JW, Kaza AK, Franceschini MA, Kussman BD, Grant PE. Non-invasive Assessment of Cerebral Blood Flow and Oxygen Metabolism in Neonates during Hypothermic Cardiopulmonary Bypass: Feasibility and Clinical Implications. Sci Rep. 2017 Mar 09; 7:44117. PMID: 28276534.
    View in: PubMed
  3. Chamberlain M, Koutsogiannaki S, Schaefers M, Babazada H, Liu R, Yuki K. The Differential Effects of Anesthetics on Bacterial Behaviors. PLoS One. 2017; 12(1):e0170089. PMID: 28099463.
    View in: PubMed
  4. Okuno T, Koutsogiannaki S, Ohba M, Chamberlain M, Bu W, Lin FY, Eckenhoff RG, Yokomizo T, Yuki K. Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production. FASEB J. 2017 Apr; 31(4):1584-1594. PMID: 28069825.
    View in: PubMed
  5. Yuki K, Matsunami E, Tazawa K, Wang W, DiNardo JA, Koutsogiannaki S. Pediatric Perioperative Stress Responses and Anesthesia. Transl Perioper Pain Med. 2017; 2(1):1-12. PMID: 28217718.
    View in: PubMed
  6. Tazawa K, Koutsogiannaki S, Chamberlain M, Yuki K. The effect of different anesthetics on tumor cytotoxicity by natural killer cells. Toxicol Lett. 2017 Jan 15; 266:23-31. PMID: 27940100.
    View in: PubMed
  7. Williams MR, Atkinson DB, Bezzerides VJ, Yuki K, Franklin K, Casta A, Alexander ME. Pausing With the Gauze: Inhibition of Temporary Pacemakers by Radiofrequency Scan During Cardiac Surgery. Anesth Analg. 2016 Nov; 123(5):1143-1148. PMID: 27644061.
    View in: PubMed
  8. Liu JR, Yuki K, Baek C, Han XH, Soriano SG. Dexmedetomidine-Induced Neuroapoptosis Is Dependent on Its Cumulative Dose. Anesth Analg. 2016 Oct; 123(4):1008-17. PMID: 27529322.
    View in: PubMed
  9. Yuki K, Eckenhoff RG. Mechanisms of the Immunological Effects of Volatile Anesthetics: A Review. Anesth Analg. 2016 Aug; 123(2):326-35. PMID: 27308954.
    View in: PubMed
  10. Lee J, Faraoni D, Lee S, Brown M, Odegard K, Randolph A, DiNardo JA, Yuki K. Incidence and risk factors for postoperative vomiting following atrial septal defect repair in children. Paediatr Anaesth. 2016 Jun; 26(6):644-8. PMID: 27091811.
    View in: PubMed
  11. Faraoni D, Zurakowski D, Vo D, Goobie SM, Yuki K, Brown ML, DiNardo JA. Post-Operative Outcomes in Children With and Without Congenital Heart Disease Undergoing Noncardiac Surgery. J Am Coll Cardiol. 2016 Feb 23; 67(7):793-801. PMID: 26892415.
    View in: PubMed
  12. Greenwald E, Yuki K. A translational consideration of intercellular adhesion molecule-1 biology in the perioperative setting. Transl Perioper Pain Med. 2016; 1(2):17-23. PMID: 27182533.
    View in: PubMed
  13. Liu JR, Han X, Soriano SG, Yuki K. Leukocyte function-associated antigen-1 deficiency impairs responses to polymicrobial sepsis. World J Clin Cases. 2015 Sep 16; 3(9):793-806. PMID: 26380827; PMCID: PMC4568529.
  14. Whiting D, Yuki K, DiNardo JA. Cardiopulmonary bypass in the pediatric population. Best Pract Res Clin Anaesthesiol. 2015 Jun; 29(2):241-56. PMID: 26060033.
    View in: PubMed
  15. Jung S, Yuki K. Differential effects of volatile anesthetics on leukocyte integrin macrophage-1 antigen. J Immunotoxicol. 2016; 13(2):148-56. PMID: 25746395; PMCID: PMC4701639.
  16. Yuki K, Murakami N. Sepsis pathophysiology and anesthetic consideration. Cardiovasc Hematol Disord Drug Targets. 2015; 15(1):57-69. PMID: 25567335; PMCID: PMC4704087.
  17. Liu JR, Han X, Soriano SG, Yuki K. The role of macrophage 1 antigen in polymicrobial sepsis. Shock. 2014 Dec; 42(6):532-9. PMID: 25075642.
    View in: PubMed
  18. Yuki K, DiNardo JA. Comparison of actual oxygen delivery kinetics to those predicted by mathematical modeling following stage 1 palliation just prior to superior cavopulmonary anastomosis. Paediatr Anaesth. 2015 Feb; 25(2):174-9. PMID: 25164862.
    View in: PubMed
  19. Bu W, Pereira LM, Eckenhoff RG, Yuki K. Stereoselectivity of isoflurane in adhesion molecule leukocyte function-associated antigen-1. PLoS One. 2014; 9(5):e96649. PMID: 24801074; PMCID: PMC4011845.
  20. Kollmann CS, Bai X, Tsai CH, Yang H, Lind KE, Skinner SR, Zhu Z, Israel DI, Cuozzo JW, Morgan BA, Yuki K, Xie C, Springer TA, Shimaoka M, Evindar G. Application of encoded library technology (ELT) to a protein-protein interaction target: discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists. Bioorg Med Chem. 2014 Apr 01; 22(7):2353-65. PMID: 24593905.
    View in: PubMed
  21. Sen M, Yuki K, Springer TA. An internal ligand-bound, metastable state of a leukocyte integrin, aXß2. J Cell Biol. 2013 Nov 25; 203(4):629-42. PMID: 24385486; PMCID: PMC3840939.
  22. Yuki K, Bu W, Xi J, Shimaoka M, Eckenhoff R. Propofol shares the binding site with isoflurane and sevoflurane on leukocyte function-associated antigen-1. Anesth Analg. 2013 Oct; 117(4):803-11. PMID: 23960033; PMCID: PMC3844542.
  23. Yuki K, Bu W, Shimaoka M, Eckenhoff R. Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin aIIbß3. PLoS One. 2013; 8(4):e60415. PMID: 23573252; PMCID: PMC3616120.
  24. Bertolizio G, Yuki K, Odegard K, Collard V, Dinardo J. Cardiac arrest and neuromuscular blockade reversal agents in the transplanted heart. J Cardiothorac Vasc Anesth. 2013 Dec; 27(6):1374-8. PMID: 23164506.
    View in: PubMed
  25. Carbo C, Yuki K, Demers M, Wagner DD, Shimaoka M. Isoflurane inhibits neutrophil recruitment in the cutaneous Arthus reaction model. J Anesth. 2013 Apr; 27(2):261-8. PMID: 23096126; PMCID: PMC3568683.
  26. Yuki K, Bu W, Xi J, Sen M, Shimaoka M, Eckenhoff RG. Isoflurane binds and stabilizes a closed conformation of the leukocyte function-associated antigen-1. FASEB J. 2012 Nov; 26(11):4408-17. PMID: 22815384; PMCID: PMC3475260.
  27. Yuki K, Emani S, DiNardo JA. A mathematical model of transitional circulation toward biventricular repair in hypoplastic left heart syndrome. Anesth Analg. 2012 Sep; 115(3):618-26. PMID: 22729965.
    View in: PubMed
  28. Yuki K, Sharma R, DiNardo J. Ventricular-assist device therapy in children. Best Pract Res Clin Anaesthesiol. 2012 Jun; 26(2):247-64. PMID: 22910093.
    View in: PubMed
  29. Ishigaki D, Okuyama H, Yuki K, Sato Y, Ogawa N, Hirono O, Kubota I. Serial evaluation of left ventricular contraction and relaxation in Takotsubo cardiomyopathy by 2D speckle tracking echocardiography. J Med Ultrason (2001). 2012 Oct; 39(4):265-9. PMID: 27279115.
    View in: PubMed
  30. Collard V, Segura LG, Daaboul DG, Yuki K. Retrograde intubation during laryngeal cleft repair on cardiopulmonary bypass. J Anesth. 2012 Apr; 26(2):273-4. PMID: 22302106.
    View in: PubMed
  31. Yuki K, Chilson K, DiNardo JA. Improvement of PaO2 during one-lung ventilation with partial left-heart bypass in pediatric patients is caused by increased blood flow to the dependent lung. J Cardiothorac Vasc Anesth. 2013 Jun; 27(3):542-5. PMID: 22285126.
    View in: PubMed
  32. Yuki K. Cell-free ligand-binding assays for integrin LFA-1. Methods Mol Biol. 2012; 757:73-8. PMID: 21909907.
    View in: PubMed
  33. Koeberle A, Shindou H, Harayama T, Yuki K, Shimizu T. Polyunsaturated fatty acids are incorporated into maturating male mouse germ cells by lysophosphatidic acid acyltransferase 3. FASEB J. 2012 Jan; 26(1):169-80. PMID: 21968070.
    View in: PubMed
  34. Wesley MC, Yuki K, Daaboul DG, Dinardo JA. Blood utilization in neonates and infants undergoing cardiac surgery requiring cardiopulmonary bypass. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):382-92. PMID: 23803991.
    View in: PubMed
  35. Daaboul DG, Yuki K, Wesley MC, Dinardo JA. Anesthetic and cardiopulmonary bypass considerations for cardiac surgery in unique pediatric patient populations: sickle cell disease and cold agglutinin disease. World J Pediatr Congenit Heart Surg. 2011 Jul 01; 2(3):364-70. PMID: 23803987.
    View in: PubMed
  36. Yuki K, Daaboul DG. Postoperative maladaptive behavioral changes in children. Middle East J Anaesthesiol. 2011 Jun; 21(2):183-9. PMID: 22435270.
    View in: PubMed
  37. Yuki K, Soriano SG, Shimaoka M. Sedative drug modulates T-cell and lymphocyte function-associated antigen-1 function. Anesth Analg. 2011 Apr; 112(4):830-8. PMID: 21385989; PMCID: PMC3073815.
  38. Yuki K, Casta A, Uezono S. Anesthetic management of noncardiac surgery for patients with single ventricle physiology. J Anesth. 2011 Apr; 25(2):247-56. PMID: 21197552.
    View in: PubMed
  39. Yuki K, Astrof NS, Bracken C, Soriano SG, Shimaoka M. Sevoflurane binds and allosterically blocks integrin lymphocyte function-associated antigen-1. Anesthesiology. 2010 Sep; 113(3):600-9. PMID: 20693879.
    View in: PubMed
  40. Okuyama H, Hirono O, Ishigaki D, Yuki K, Kubota I. Percutaneous transvenous stent implantation to external iliac vein stenosis in a patient with retroperitoneal fibrosis. Intern Med. 2010; 49(10):913-8. PMID: 20467176.
    View in: PubMed
  41. Yuki K, Sakuramoto C, Matsumoto C, Hoshino M, Niimi Y. The effect of left heart bypass on pulmonary blood flow and arterial oxygenation during one-lung ventilation in patients undergoing descending thoracic aortic surgery. J Clin Anesth. 2009 Dec; 21(8):562-6. PMID: 20122587.
    View in: PubMed
  42. Yuki K, Casta A. Management of difficult airway in pediatric patients with right ventricular outflow tract obstruction. J Anesth. 2009; 23(2):281-3. PMID: 19444572.
    View in: PubMed
  43. Yuki K, Shindou H, Hishikawa D, Shimizu T. Characterization of mouse lysophosphatidic acid acyltransferase 3: an enzyme with dual functions in the testis. J Lipid Res. 2009 May; 50(5):860-9. PMID: 19114731; PMCID: PMC2666172.
  44. Shindou H, Hishikawa D, Harayama T, Yuki K, Shimizu T. Recent progress on acyl CoA: lysophospholipid acyltransferase research. J Lipid Res. 2009 Apr; 50 Suppl:S46-51. PMID: 18931347; PMCID: PMC2674719.
  45. Yuki K, Astrof NS, Bracken C, Yoo R, Silkworth W, Soriano SG, Shimaoka M. The volatile anesthetic isoflurane perturbs conformational activation of integrin LFA-1 by binding to the allosteric regulatory cavity. FASEB J. 2008 Dec; 22(12):4109-16. PMID: 18708587; PMCID: PMC2614612.
  46. Yuki K, Chilson K, Odegard KC, DiNardo JA. Trendelenburg position, simulated Valsalva maneuver, and liver compression do not alter the size of the right internal jugular vein in patients with a bidirectional Glenn shunt. Anesth Analg. 2007 Aug; 105(2):365-8. PMID: 17646491.
    View in: PubMed
  47. Yuki K, Shamberger RC, McGowan FX, Seefelder C. The perioperative management of a patient with Fontan physiology for pheochromocytoma resection. J Cardiothorac Vasc Anesth. 2008 Oct; 22(5):748-50. PMID: 18922437.
    View in: PubMed
  48. Casta A, Brown DW, Yuki K. Induction of supraventricular tachycardia during transesophageal echocardiography: an unusual complication. J Cardiothorac Vasc Anesth. 2008 Aug; 22(4):592-3. PMID: 18662640.
    View in: PubMed
  49. Kakinuma Y, Miyauchi T, Suzuki T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Enhancement of glycolysis in cardiomyocytes elevates endothelin-1 expression through the transcriptional factor hypoxia-inducible factor-1 alpha. Clin Sci (Lond). 2002 Aug; 103 Suppl 48:210S-214S. PMID: 12193088.
    View in: PubMed
  50. Yuki K, Suzuki T, Katoh S, Kakinuma Y, Miyauchi T, Mitsui Y. Endothelin-1 stimulates cardiomyocyte injury during mitochondrial dysfunction in culture. Eur J Pharmacol. 2001 Nov 16; 431(2):163-70. PMID: 11728422.
    View in: PubMed
  51. Fujiwara S, Takeishi Y, Hirono O, Fukui A, Okuyama M, Yamaguchi S, Ito M, Kaneko K, Shishido T, Miyamoto T, Yuki K, Miyashita T, Takahashi K, Minamihaba O, Tomoike H, Yamauchi S, Fatema K. Reverse redistribution of 99m Tc-sestamibi after direct percutaneous transluminal coronary angioplasty in acute myocardial infarction: relationship with wall motion and functional response to dobutamine stimulation. Nucl Med Commun. 2001 Nov; 22(11):1223-30. PMID: 11606888.
    View in: PubMed
  52. Kumagai Y, Hayashi T, Miyauchi T, Endo A, Iguchi A, Kiriya-Sakai M, Sakai S, Yuki K, Kikushima M, Shimojo N. Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. Am J Physiol Regul Integr Comp Physiol. 2001 Jul; 281(1):R25-30. PMID: 11404275.
    View in: PubMed
  53. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Novel molecular mechanism of increased myocardial endothelin-1 expression in the failing heart involving the transcriptional factor hypoxia-inducible factor-1alpha induced for impaired myocardial energy metabolism. Circulation. 2001 May 15; 103(19):2387-94. PMID: 11352889.
    View in: PubMed
  54. Murakoshi N, Miyauchi T, Kakinuma Y, Yuki K, Goto K, Yamaguchi I. Impairment of cardiac energy metabolism in vivo causes hemodynamic abnormality and increases cardiac expression of preproendothelin-1 mRNA. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S128-31. PMID: 11078357.
    View in: PubMed
  55. Yuki K, Miyauchi T, Kakinuma Y, Murakoshi N, Suzuki T, Hayashi J, Goto K, Yamaguchi I. Mitochondrial dysfunction increases expression of endothelin-1 and induces apoptosis through caspase-3 activation in rat cardiomyocytes in vitro. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S205-8. PMID: 11078378.
    View in: PubMed
  56. Kakinuma Y, Miyauchi T, Yuki K, Murakoshi N, Goto K, Yamaguchi I. Mitochondrial dysfunction of cardiomyocytes causing impairment of cellular energy metabolism induces apoptosis, and concomitant increase in cardiac endothelin-1 expression. J Cardiovasc Pharmacol. 2000 Nov; 36(5 Suppl 1):S201-4. PMID: 11078377.
    View in: PubMed
  57. Iemitsu M, Miyauchi T, Maeda S, Yuki K, Kobayashi T, Kumagai Y, Shimojo N, Yamaguchi I, Matsuda M. Intense exercise causes decrease in expression of both endothelial NO synthase and tissue NOx level in hearts. Am J Physiol Regul Integr Comp Physiol. 2000 Sep; 279(3):R951-9. PMID: 10956253.
    View in: PubMed
  58. Pi J, Kumagai Y, Sun G, Yamauchi H, Yoshida T, Iso H, Endo A, Yu L, Yuki K, Miyauchi T, Shimojo N. Decreased serum concentrations of nitric oxide metabolites among Chinese in an endemic area of chronic arsenic poisoning in inner Mongolia. Free Radic Biol Med. 2000 Apr 01; 28(7):1137-42. PMID: 10832076.
    View in: PubMed
  59. Nagai S, Abe S, Sato T, Hozawa K, Yuki K, Hanashima K, Tomoike H. Ultrasonic assessment of vascular complications in coronary angiography and angioplasty after transradial approach. Am J Cardiol. 1999 Jan 15; 83(2):180-6. PMID: 10073818.
    View in: PubMed
  60. Kakinuma Y, Miyauchi T, Kobayashi T, Yuki K, Maeda S, Sakai S, Goto K, Yamaguchi I. Myocardial expression of endothelin-2 is altered reciprocally to that of endothelin-1 during ischemia of cardiomyocytes in vitro and during heart failure in vivo. Life Sci. 1999; 65(16):1671-83. PMID: 10573185.
    View in: PubMed
  61. Naito H, Miyoshi A, Nakatsuka M, Yuki K, Yamada H, Kobayashi Y, Tanimoto Y. [A case of unruptured aneurysm of the sinus of Valsalva producing a right ventricular outflow obstruction]. Kokyu To Junkan. 1985 Apr; 33(4):581-5. PMID: 4012087.
    View in: PubMed
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