Harvard Catalyst Profiles

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Sean Megason, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HD096755 (MEGASON, SEAN G) Aug 20, 2018 - Apr 30, 2023
    NIH/NICHD
    Mapping the signaling landscape of vertebrate development at single cell resolution
    Role: Principal Investigator
  2. R01DC015478 (MEGASON, SEAN G) Feb 9, 2017 - Jan 31, 2022
    NIH/NIDCD
    The mechanism of inner ear pressure homeostasis by the endolymphatic sac
    Role: Principal Investigator
  3. R01GM107733 (MEGASON, SEAN G) Apr 13, 2015 - Jan 31, 2019
    NIH/NIGMS
    Dynamic regulatory mechanisms of robust pattern formation in the neural tube
    Role: Principal Investigator
  4. R21DC012097 (MEGASON, SEAN G) Jan 10, 2012 - Dec 31, 2014
    NIH/NIDCD
    Streamlined cloning of auditory and vestibular mutants by whole genome sequencing
    Role: Principal Investigator
  5. R01DC010791 (MEGASON, SEAN G) Feb 15, 2010 - Jan 31, 2015
    NIH/NIDCD
    In toto imaging and genomics to decode ear hair cell formation and regeneration
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Megason Laboratory - Instruments (7), Protocols (29) and Software (6)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. O'Brown ZK, Boulias K, Wang J, Wang SY, O'Brown NM, Hao Z, Shibuya H, Fady PE, Shi Y, He C, Megason SG, Liu T, Greer EL. Sources of artifact in measurements of 6mA and 4mC abundance in eukaryotic genomic DNA. BMC Genomics. 2019 Jun 03; 20(1):445. PMID: 31159718.
    Citations:    
  2. Ishimatsu K, Cha A, Collins ZM, Megason SG. Surgical Size Reduction of Zebrafish for the Study of Embryonic Pattern Scaling. J Vis Exp. 2019 May 03; (147). PMID: 31107459.
    Citations:    
  3. Gao R, Asano SM, Upadhyayula S, Pisarev I, Milkie DE, Liu TL, Singh V, Graves A, Huynh GH, Zhao Y, Bogovic J, Colonell J, Ott CM, Zugates C, Tappan S, Rodriguez A, Mosaliganti KR, Sheu SH, Pasolli HA, Pang S, Xu CS, Megason SG, Hess H, Lippincott-Schwartz J, Hantman A, Rubin GM, Kirchhausen T, Saalfeld S, Aso Y, Boyden ES, Betzig E. Cortical column and whole-brain imaging with molecular contrast and nanoscale resolution. Science. 2019 01 18; 363(6424). PMID: 30655415.
    Citations:    Fields:    
  4. Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. Elife. 2018 06 19; 7. PMID: 29916365.
    Citations:    Fields:    
  5. Ishimatsu K, Hiscock TW, Collins ZM, Sari DWK, Lischer K, Richmond DL, Bessho Y, Matsui T, Megason SG. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Development. 2018 06 11; 145(11). PMID: 29769221.
    Citations:    Fields:    Translation:Animals
  6. Hiscock TW, Miesfeld JB, Mosaliganti KR, Link BA, Megason SG. Feedback between tissue packing and neurogenesis in the zebrafish neural tube. Development. 2018 May 04; 145(9). PMID: 29678815.
    Citations:    Fields:    Translation:AnimalsCells
  7. Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science. 2018 06 01; 360(6392). PMID: 29700227.
    Citations: 7     Fields:    Translation:AnimalsCells
  8. Wagner DE, Weinreb C, Collins ZM, Briggs JA, Megason SG, Klein AM. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science. 2018 06 01; 360(6392):981-987. PMID: 29700229.
    Citations: 8     Fields:    Translation:Animals
  9. Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. 2018 04 20; 360(6386). PMID: 29674564.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  10. Megason SG. Dynamic Encoding in the Notch Pathway. Dev Cell. 2018 02 26; 44(4):411-412. PMID: 29486192.
    Citations:    Fields:    Translation:HumansCells
  11. Green AA, Mosaliganti KR, Swinburne IA, Obholzer ND, Megason SG. Recovery of shape and size in a developing organ pair. Dev Dyn. 2017 06; 246(6):451-465. PMID: 28295855.
    Citations:    Fields:    Translation:Animals
  12. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435. PMID: 27535432.
    Citations: 10     Fields:    Translation:AnimalsCells
  13. Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016 10 01; 418(1):108-123. PMID: 27474396.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Lee SG, Huang M, Obholzer ND, Sun S, Li W, Petrillo M, Dai P, Zhou Y, Cotanche DA, Megason SG, Li H, Chen ZY. Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration. PLoS One. 2016; 11(6):e0157768. PMID: 27351484.
    Citations:    Fields:    Translation:AnimalsCells
  15. Hiscock TW, Megason SG. Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies. Cell Syst. 2015 Dec 23; 1(6):408-416. PMID: 26771020.
    Citations:    Fields:    
  16. Swinburne IA, Mosaliganti KR, Green AA, Megason SG. Improved Long-Term Imaging of Embryos with Genetically Encoded a-Bungarotoxin. PLoS One. 2015; 10(8):e0134005. PMID: 26244658.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Xiong F, Megason SG. Abstracting the principles of development using imaging and modeling. Integr Biol (Camb). 2015 Jun; 7(6):633-42. PMID: 25946995.
    Citations:    Fields:    Translation:Animals
  18. Xiong F, Obholzer ND, Noche RR, Megason SG. Multibow: digital spectral barcodes for cell tracing. PLoS One. 2015; 10(5):e0127822. PMID: 26010570.
    Citations: 1     Fields:    Translation:AnimalsCells
  19. Stooke-Vaughan GA, Obholzer ND, Baxendale S, Megason SG, Whitfield TT. Otolith tethering in the zebrafish otic vesicle requires Otogelin and a-Tectorin. Development. 2015 Mar 15; 142(6):1137-45. PMID: 25758224.
    Citations: 6     Fields:    Translation:HumansAnimals
  20. Hiscock TW, Megason SG. Mathematically guided approaches to distinguish models of periodic patterning. Development. 2015 Feb 01; 142(3):409-19. PMID: 25605777.
    Citations: 13     Fields:    Translation:AnimalsCells
  21. Xiong F, Ma W, Hiscock TW, Mosaliganti KR, Tentner AR, Brakke KA, Rannou N, Gelas A, Souhait L, Swinburne IA, Obholzer ND, Megason SG. Interplay of cell shape and division orientation promotes robust morphogenesis of developing epithelia. Cell. 2014 Oct 09; 159(2):415-27. PMID: 25303534.
    Citations: 19     Fields:    Translation:AnimalsCells
  22. Mosaliganti KR, Gelas A, Megason SG. An efficient, scalable, and adaptable framework for solving generic systems of level-set PDEs. Front Neuroinform. 2013; 7:35. PMID: 24501592.
    Citations: 2     
  23. Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, Rannou N, Swinburne IA, Obholzer ND, Cowgill PD, Schier AF, Megason SG. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell. 2013 Apr 25; 153(3):550-61. PMID: 23622240.
    Citations: 40     Fields:    Translation:AnimalsCells
  24. Miller AC, Obholzer ND, Shah AN, Megason SG, Moens CB. RNA-seq-based mapping and candidate identification of mutations from forward genetic screens. Genome Res. 2013 Apr; 23(4):679-86. PMID: 23299976.
    Citations: 30     Fields:    Translation:AnimalsCells
  25. Mosaliganti KR, Noche RR, Xiong F, Swinburne IA, Megason SG. ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes. PLoS Comput Biol. 2012; 8(12):e1002780. PMID: 23236265.
    Citations: 27     Fields:    Translation:AnimalsCells
  26. Obholzer N, Swinburne IA, Schwab E, Nechiporuk AV, Nicolson T, Megason SG. Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Development. 2012 Nov; 139(22):4280-90. PMID: 23052906.
    Citations: 30     Fields:    Translation:AnimalsCells
  27. Shaheen R, Faqeih E, Shamseldin HE, Noche RR, Sunker A, Alshammari MJ, Al-Sheddi T, Adly N, Al-Dosari MS, Megason SG, Al-Husain M, Al-Mohanna F, Alkuraya FS. POC1A truncation mutation causes a ciliopathy in humans characterized by primordial dwarfism. Am J Hum Genet. 2012 Aug 10; 91(2):330-6. PMID: 22840364.
    Citations: 27     Fields:    Translation:HumansCells
  28. Huang P, Xiong F, Megason SG, Schier AF. Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet. 2012; 8(6):e1002762. PMID: 22685423.
    Citations: 20     Fields:    Translation:AnimalsCells
  29. Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell. 2012 Mar 13; 22(3):625-38. PMID: 22421047.
    Citations: 21     Fields:    Translation:AnimalsCells
  30. Trinh le A, Hochgreb T, Graham M, Wu D, Ruf-Zamojski F, Jayasena CS, Saxena A, Hawk R, Gonzalez-Serricchio A, Dixson A, Chow E, Gonzales C, Leung HY, Solomon I, Bronner-Fraser M, Megason SG, Fraser SE. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev. 2011 Nov 01; 25(21):2306-20. PMID: 22056673.
    Citations: 44     Fields:    Translation:Animals
  31. Megason SG, Srinivas S, Dickinson ME, Hadjantonakis AK. Microscopy to mechanism across the scales of development. Curr Opin Genet Dev. 2011 Oct; 21(5):519-22. PMID: 21996420.
    Citations: 3     Fields:    
  32. Agapakis CM, Niederholtmeyer H, Noche RR, Lieberman TD, Megason SG, Way JC, Silver PA. Towards a synthetic chloroplast. PLoS One. 2011 Apr 20; 6(4):e18877. PMID: 21533097.
    Citations: 13     Fields:    Translation:AnimalsCells
  33. Wühr M, Obholzer ND, Megason SG, Detrich HW, Mitchison TJ. Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos. Methods Cell Biol. 2011; 101:1-18. PMID: 21550437.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  34. Mosaliganti K, Janoos F, Gelas A, Noche R, Obholzer N, Machiraju R, Megason SG. ANISOTROPIC PLATE DIFFUSION FILTERING FOR DETECTION OF CELL MEMBRANES IN 3D MICROSCOPY IMAGES. Proc IEEE Int Symp Biomed Imaging. 2010; 588-591. PMID: 21766060.
    Citations: 2     
  35. Gelas A, Mosaliganti K, Gouaillard A, Souhait L, Noche R, Obholzer N, Megason SG. VARIATIONAL LEVEL-SET WITH GAUSSIAN SHAPE MODEL FOR CELL SEGMENTATION. Proc Int Conf Image Proc. 2009; 1089-1092. PMID: 21738904.
    Citations: 2     
  36. Mosaliganti K, Gelas A, Gouaillard A, Megason SG. TISSUE LEVEL SEGMENTATION AND TRACKING OF BIOLOGICAL STRUCTURES IN MICROSCOPIC IMAGES BASED ON DENSITY MAPS. Proc IEEE Int Symp Biomed Imaging. 2009; 1354-1357. PMID: 21766061.
    Citations:    
  37. Gouaillard A, Mosaliganti K, Gelas A, Souhait L, Obholzer N, Megason S. Streaming level set algorithm for 3D segmentation of confocal microscopy images. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:3621-4. PMID: 19964083.
    Citations:    Fields:    Translation:HumansCells
  38. Mosaliganti K, Gelas A, Gouaillard A, Noche R, Obholzer N, Megason S. Detection of spatially correlated objects in 3D images using appearance models and coupled active contours. Med Image Comput Comput Assist Interv. 2009; 12(Pt 2):641-8. PMID: 20426166.
    Citations: 2     Fields:    Translation:HumansCells
  39. Megason SG. In toto imaging of embryogenesis with confocal time-lapse microscopy. Methods Mol Biol. 2009; 546:317-32. PMID: 19378112.
    Citations: 34     Fields:    Translation:Animals
  40. Megason SG, Fraser SE. Imaging in systems biology. Cell. 2007 Sep 07; 130(5):784-95. PMID: 17803903.
    Citations: 86     Fields:    Translation:AnimalsCells
  41. Megason S, Amsterdam A, Hopkins N, Lin S. Uses of GFP in transgenic vertebrates. Methods Biochem Anal. 2006; 47:285-303. PMID: 16335718.
    Citations: 2     Fields:    Translation:Animals
  42. Megason SG, Fraser SE. Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development. Mech Dev. 2003 Nov; 120(11):1407-20. PMID: 14623446.
    Citations: 51     Fields:    Translation:Animals
  43. Megason SG, McMahon AP. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 2002 May; 129(9):2087-98. PMID: 11959819.
    Citations: 211     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.