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Sean Megason, PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DC015478 (MEGASON, SEAN G) Feb 9, 2017 - Jan 31, 2022
    NIH/NIDCD
    The mechanism of inner ear pressure homeostasis by the endolymphatic sac
    Role: Principal Investigator
  2. R01GM107733 (MEGASON, SEAN G) Apr 13, 2015 - Jan 31, 2019
    NIH/NIGMS
    Dynamic regulatory mechanisms of robust pattern formation in the neural tube
    Role: Principal Investigator
  3. R21DC012097 (MEGASON, SEAN G) Jan 10, 2012 - Dec 31, 2014
    NIH/NIDCD
    Streamlined cloning of auditory and vestibular mutants by whole genome sequencing
    Role: Principal Investigator
  4. R01DC010791 (MEGASON, SEAN G) Feb 15, 2010 - Jan 31, 2015
    NIH/NIDCD
    In toto imaging and genomics to decode ear hair cell formation and regeneration
    Role: Principal Investigator
This researcher has shared information about their research resources in the eagle-i Network. To update or add resource records, contact eagle-i@hms.harvard.edu.
Megason Laboratory - Instruments (7), Protocols (29) and Software (6)

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Swinburne IA, Mosaliganti KR, Upadhyayula S, Liu TL, Hildebrand DGC, Tsai TY, Chen A, Al-Obeidi E, Fass AK, Malhotra S, Engert F, Lichtman JW, Kirchhausen T, Betzig E, Megason SG. Lamellar projections in the endolymphatic sac act as a relief valve to regulate inner ear pressure. Elife. 2018 06 19; 7. PMID: 29916365.
    View in: PubMed
  2. Ishimatsu K, Hiscock TW, Collins ZM, Sari DWK, Lischer K, Richmond DL, Bessho Y, Matsui T, Megason SG. Size-reduced embryos reveal a gradient scaling-based mechanism for zebrafish somite formation. Development. 2018 06 11; 145(11). PMID: 29769221.
    View in: PubMed
  3. Hiscock TW, Miesfeld JB, Mosaliganti KR, Link BA, Megason SG. Feedback between tissue packing and neurogenesis in the zebrafish neural tube. Development. 2018 May 04; 145(9). PMID: 29678815.
    View in: PubMed
  4. Briggs JA, Weinreb C, Wagner DE, Megason S, Peshkin L, Kirschner MW, Klein AM. The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution. Science. 2018 06 01; 360(6392). PMID: 29700227.
    View in: PubMed
  5. Wagner DE, Weinreb C, Collins ZM, Briggs JA, Megason SG, Klein AM. Single-cell mapping of gene expression landscapes and lineage in the zebrafish embryo. Science. 2018 06 01; 360(6392):981-987. PMID: 29700229.
    View in: PubMed
  6. Liu TL, Upadhyayula S, Milkie DE, Singh V, Wang K, Swinburne IA, Mosaliganti KR, Collins ZM, Hiscock TW, Shea J, Kohrman AQ, Medwig TN, Dambournet D, Forster R, Cunniff B, Ruan Y, Yashiro H, Scholpp S, Meyerowitz EM, Hockemeyer D, Drubin DG, Martin BL, Matus DQ, Koyama M, Megason SG, Kirchhausen T, Betzig E. Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms. Science. 2018 04 20; 360(6386). PMID: 29674564.
    View in: PubMed
  7. Megason SG. Dynamic Encoding in the Notch Pathway. Dev Cell. 2018 02 26; 44(4):411-412. PMID: 29486192.
    View in: PubMed
  8. Green AA, Mosaliganti KR, Swinburne IA, Obholzer ND, Megason SG. Recovery of shape and size in a developing organ pair. Dev Dyn. 2017 06; 246(6):451-465. PMID: 28295855.
    View in: PubMed
  9. Aguet F, Upadhyayula S, Gaudin R, Chou YY, Cocucci E, He K, Chen BC, Mosaliganti K, Pasham M, Skillern W, Legant WR, Liu TL, Findlay G, Marino E, Danuser G, Megason S, Betzig E, Kirchhausen T. Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy. Mol Biol Cell. 2016 11 07; 27(22):3418-3435. PMID: 27535432.
    View in: PubMed
  10. Nissim S, Weeks O, Talbot JC, Hedgepeth JW, Wucherpfennig J, Schatzman-Bone S, Swinburne I, Cortes M, Alexa K, Megason S, North TE, Amacher SL, Goessling W. Iterative use of nuclear receptor Nr5a2 regulates multiple stages of liver and pancreas development. Dev Biol. 2016 10 01; 418(1):108-123. PMID: 27474396.
    View in: PubMed
  11. Lee SG, Huang M, Obholzer ND, Sun S, Li W, Petrillo M, Dai P, Zhou Y, Cotanche DA, Megason SG, Li H, Chen ZY. Myc and Fgf Are Required for Zebrafish Neuromast Hair Cell Regeneration. PLoS One. 2016; 11(6):e0157768. PMID: 27351484; PMCID: PMC4924856.
  12. Hiscock TW, Megason SG. Orientation of Turing-like Patterns by Morphogen Gradients and Tissue Anisotropies. Cell Syst. 2015 Dec 23; 1(6):408-416. PMID: 26771020.
    View in: PubMed
  13. Swinburne IA, Mosaliganti KR, Green AA, Megason SG. Improved Long-Term Imaging of Embryos with Genetically Encoded a-Bungarotoxin. PLoS One. 2015; 10(8):e0134005. PMID: 26244658; PMCID: PMC4526548.
  14. Xiong F, Megason SG. Abstracting the principles of development using imaging and modeling. Integr Biol (Camb). 2015 Jun; 7(6):633-42. PMID: 25946995; PMCID: PMC4461478.
  15. Xiong F, Obholzer ND, Noche RR, Megason SG. Multibow: digital spectral barcodes for cell tracing. PLoS One. 2015; 10(5):e0127822. PMID: 26010570; PMCID: PMC4444339.
  16. Stooke-Vaughan GA, Obholzer ND, Baxendale S, Megason SG, Whitfield TT. Otolith tethering in the zebrafish otic vesicle requires Otogelin and a-Tectorin. Development. 2015 Mar 15; 142(6):1137-45. PMID: 25758224; PMCID: PMC4360185.
  17. Hiscock TW, Megason SG. Mathematically guided approaches to distinguish models of periodic patterning. Development. 2015 Feb 01; 142(3):409-19. PMID: 25605777; PMCID: PMC4302999.
  18. Xiong F, Ma W, Hiscock TW, Mosaliganti KR, Tentner AR, Brakke KA, Rannou N, Gelas A, Souhait L, Swinburne IA, Obholzer ND, Megason SG. Interplay of cell shape and division orientation promotes robust morphogenesis of developing epithelia. Cell. 2014 Oct 09; 159(2):415-27. PMID: 25303534; PMCID: PMC4273647.
  19. Mosaliganti KR, Gelas A, Megason SG. An efficient, scalable, and adaptable framework for solving generic systems of level-set PDEs. Front Neuroinform. 2013; 7:35. PMID: 24501592; PMCID: PMC3872740.
  20. Xiong F, Tentner AR, Huang P, Gelas A, Mosaliganti KR, Souhait L, Rannou N, Swinburne IA, Obholzer ND, Cowgill PD, Schier AF, Megason SG. Specified neural progenitors sort to form sharp domains after noisy Shh signaling. Cell. 2013 Apr 25; 153(3):550-61. PMID: 23622240; PMCID: PMC3674856.
  21. Miller AC, Obholzer ND, Shah AN, Megason SG, Moens CB. RNA-seq-based mapping and candidate identification of mutations from forward genetic screens. Genome Res. 2013 Apr; 23(4):679-86. PMID: 23299976; PMCID: PMC3613584.
  22. Mosaliganti KR, Noche RR, Xiong F, Swinburne IA, Megason SG. ACME: automated cell morphology extractor for comprehensive reconstruction of cell membranes. PLoS Comput Biol. 2012; 8(12):e1002780. PMID: 23236265; PMCID: PMC3516542.
  23. Obholzer N, Swinburne IA, Schwab E, Nechiporuk AV, Nicolson T, Megason SG. Rapid positional cloning of zebrafish mutations by linkage and homozygosity mapping using whole-genome sequencing. Development. 2012 Nov; 139(22):4280-90. PMID: 23052906; PMCID: PMC3478692.
  24. Shaheen R, Faqeih E, Shamseldin HE, Noche RR, Sunker A, Alshammari MJ, Al-Sheddi T, Adly N, Al-Dosari MS, Megason SG, Al-Husain M, Al-Mohanna F, Alkuraya FS. POC1A truncation mutation causes a ciliopathy in humans characterized by primordial dwarfism. Am J Hum Genet. 2012 Aug 10; 91(2):330-6. PMID: 22840364; PMCID: PMC3415549.
  25. Huang P, Xiong F, Megason SG, Schier AF. Attenuation of Notch and Hedgehog signaling is required for fate specification in the spinal cord. PLoS Genet. 2012; 8(6):e1002762. PMID: 22685423; PMCID: PMC3369957.
  26. Xu C, Fan ZP, Müller P, Fogley R, DiBiase A, Trompouki E, Unternaehrer J, Xiong F, Torregroza I, Evans T, Megason SG, Daley GQ, Schier AF, Young RA, Zon LI. Nanog-like regulates endoderm formation through the Mxtx2-Nodal pathway. Dev Cell. 2012 Mar 13; 22(3):625-38. PMID: 22421047; PMCID: PMC3319042.
  27. Trinh le A, Hochgreb T, Graham M, Wu D, Ruf-Zamojski F, Jayasena CS, Saxena A, Hawk R, Gonzalez-Serricchio A, Dixson A, Chow E, Gonzales C, Leung HY, Solomon I, Bronner-Fraser M, Megason SG, Fraser SE. A versatile gene trap to visualize and interrogate the function of the vertebrate proteome. Genes Dev. 2011 Nov 01; 25(21):2306-20. PMID: 22056673; PMCID: PMC3219234.
  28. Megason SG, Srinivas S, Dickinson ME, Hadjantonakis AK. Microscopy to mechanism across the scales of development. Curr Opin Genet Dev. 2011 Oct; 21(5):519-22. PMID: 21996420; PMCID: PMC3289100.
  29. Agapakis CM, Niederholtmeyer H, Noche RR, Lieberman TD, Megason SG, Way JC, Silver PA. Towards a synthetic chloroplast. PLoS One. 2011 Apr 20; 6(4):e18877. PMID: 21533097.
    View in: PubMed
  30. Wühr M, Obholzer ND, Megason SG, Detrich HW, Mitchison TJ. Live imaging of the cytoskeleton in early cleavage-stage zebrafish embryos. Methods Cell Biol. 2011; 101:1-18. PMID: 21550437.
    View in: PubMed
  31. Mosaliganti K, Janoos F, Gelas A, Noche R, Obholzer N, Machiraju R, Megason SG. ANISOTROPIC PLATE DIFFUSION FILTERING FOR DETECTION OF CELL MEMBRANES IN 3D MICROSCOPY IMAGES. Proc IEEE Int Symp Biomed Imaging. 2010; 588-591. PMID: 21766060.
    View in: PubMed
  32. Gelas A, Mosaliganti K, Gouaillard A, Souhait L, Noche R, Obholzer N, Megason SG. VARIATIONAL LEVEL-SET WITH GAUSSIAN SHAPE MODEL FOR CELL SEGMENTATION. Proc Int Conf Image Proc. 2009; 1089-1092. PMID: 21738904.
    View in: PubMed
  33. Mosaliganti K, Gelas A, Gouaillard A, Megason SG. TISSUE LEVEL SEGMENTATION AND TRACKING OF BIOLOGICAL STRUCTURES IN MICROSCOPIC IMAGES BASED ON DENSITY MAPS. Proc IEEE Int Symp Biomed Imaging. 2009; 1354-1357. PMID: 21766061.
    View in: PubMed
  34. Gouaillard A, Mosaliganti K, Gelas A, Souhait L, Obholzer N, Megason S. Streaming level set algorithm for 3D segmentation of confocal microscopy images. Conf Proc IEEE Eng Med Biol Soc. 2009; 2009:3621-4. PMID: 19964083; PMCID: PMC3136103.
  35. Mosaliganti K, Gelas A, Gouaillard A, Noche R, Obholzer N, Megason S. Detection of spatially correlated objects in 3D images using appearance models and coupled active contours. Med Image Comput Comput Assist Interv. 2009; 12(Pt 2):641-8. PMID: 20426166; PMCID: PMC3115640.
  36. Megason SG. In toto imaging of embryogenesis with confocal time-lapse microscopy. Methods Mol Biol. 2009; 546:317-32. PMID: 19378112; PMCID: PMC2826616.
  37. Megason SG, Fraser SE. Imaging in systems biology. Cell. 2007 Sep 07; 130(5):784-95. PMID: 17803903.
    View in: PubMed
  38. Megason S, Amsterdam A, Hopkins N, Lin S. Uses of GFP in transgenic vertebrates. Methods Biochem Anal. 2006; 47:285-303. PMID: 16335718.
    View in: PubMed
  39. Megason SG, Fraser SE. Digitizing life at the level of the cell: high-performance laser-scanning microscopy and image analysis for in toto imaging of development. Mech Dev. 2003 Nov; 120(11):1407-20. PMID: 14623446.
    View in: PubMed
  40. Megason SG, McMahon AP. A mitogen gradient of dorsal midline Wnts organizes growth in the CNS. Development. 2002 May; 129(9):2087-98. PMID: 11959819.
    View in: PubMed
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.