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James Daniel Akula, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01EY028953 (AKULA, JAMES DANIEL) Sep 30, 2019 - Jun 30, 2022
    Noninvasive Protection Against Retinopathy of Prematurity
    Role: Principal Investigator
  2. RC1EY020308 (AKULA, JAMES DANIEL) Sep 30, 2009 - Sep 29, 2012
    Downregulation of Rod Metabolism in Retinopathy of Prematurity
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Fonseca MI, Nouck-A-Nwal A, Ambrosio L, Altschwager P, Hansen RM, Fulton AB, Akula JD. The relation of the multifocal electroretinographic response to macular layer volume. Doc Ophthalmol. 2022 08; 145(1):1-10. PMID: 35536490.
    Citations:    Fields:    Translation:Humans
  2. Wiecek E, Akula JD, Vanderveen DK, Mantagos IS, Wu C, Curran AL, De Bruyn H, Peterson B, Fulton AB. Longitudinal Change of Refractive Error in Retinopathy of Prematurity Treated With Intravitreal Bevacizumab or Laser Photocoagulation. Am J Ophthalmol. 2022 08; 240:252-259. PMID: 35367438; PMCID: PMC9308642.
    Citations:    Fields:    Translation:Humans
  3. Fu Z, Yan W, Chen CT, Nilsson AK, Bull E, Allen W, Yang J, Ko M, SanGiovanni JP, Akula JD, Talukdar S, Hellström A, Smith LEH. Omega-3/Omega-6 Long-Chain Fatty Acid Imbalance in Phase I Retinopathy of Prematurity. Nutrients. 2022 Mar 23; 14(7). PMID: 35405946; PMCID: PMC9002570.
    Citations:    Fields:    Translation:HumansAnimals
  4. Fu Z, Qiu C, Cagnone G, Tomita Y, Huang S, Cakir B, Kotoda Y, Allen W, Bull E, Akula JD, Joyal JS, Hellström A, Talukdar S, Smith LEH. Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration. iScience. 2021 Apr 23; 24(4):102376. PMID: 33937726.
    Citations: 4     
  5. Ambrosio L, Williams JS, Gutierrez A, Swanson EA, Munro RJ, Ferguson RD, Fulton AB, Akula JD. Carbonic anhydrase inhibition in X-linked retinoschisis: An eye on the photoreceptors. Exp Eye Res. 2021 01; 202:108344. PMID: 33186570.
    Citations: 2     Fields:    Translation:HumansCells
  6. Akula JD, Arellano IA, Swanson EA, Favazza TL, Bowe TS, Munro RJ, Ferguson RD, Hansen RM, Moskowitz A, Fulton AB. The Fovea in Retinopathy of Prematurity. Invest Ophthalmol Vis Sci. 2020 09 01; 61(11):28. PMID: 32936301.
    Citations: 4     Fields:    Translation:Humans
  7. Akula JD, Ambrosio L, Howard FI, Hansen RM, Fulton AB. Extracting the ON and OFF contributions to the full-field photopic flash electroretinogram using summed growth curves. Exp Eye Res. 2019 12; 189:107827. PMID: 31600486.
    Citations:    Fields:    Translation:HumansCells
  8. Chi ZL, Adini A, Birsner AE, Bazinet L, Akula JD, D'Amato RJ. PR1P ameliorates neurodegeneration through activation of VEGF signaling pathway and remodeling of the extracellular environment. Neuropharmacology. 2019 04; 148:96-106. PMID: 30594697.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  9. Fu Z, Wang Z, Liu CH, Gong Y, Cakir B, Liegl R, Sun Y, Meng SS, Burnim SB, Arellano I, Moran E, Duran R, Poblete A, Cho SS, Talukdar S, Akula JD, Hellström A, Smith LEH. Fibroblast Growth Factor 21 Protects Photoreceptor Function in Type 1 Diabetic Mice. Diabetes. 2018 05; 67(5):974-985. PMID: 29487115; PMCID: PMC5909994.
    Citations: 27     Fields:    Translation:AnimalsCells
  10. Fu Z, Löfqvist CA, Liegl R, Wang Z, Sun Y, Gong Y, Liu CH, Meng SS, Burnim SB, Arellano I, Chouinard MT, Duran R, Poblete A, Cho SS, Akula JD, Kinter M, Ley D, Pupp IH, Talukdar S, Hellström A, Smith LE. Photoreceptor glucose metabolism determines normal retinal vascular growth. EMBO Mol Med. 2018 01; 10(1):76-90. PMID: 29180355.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  11. Sun Y, Lin Z, Liu CH, Gong Y, Liegl R, Fredrick TW, Meng SS, Burnim SB, Wang Z, Akula JD, Pu WT, Chen J, Smith LEH. Inflammatory signals from photoreceptor modulate pathological retinal angiogenesis via c-Fos. J Exp Med. 2017 06 05; 214(6):1753-1767. PMID: 28465464; PMCID: PMC5461000.
    Citations: 31     Fields:    Translation:AnimalsCells
  12. Hansen RM, Moskowitz A, Akula JD, Fulton AB. The neural retina in retinopathy of prematurity. Prog Retin Eye Res. 2017 01; 56:32-57. PMID: 27671171; PMCID: PMC5237602.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  13. Wang Z, Liu CH, Sun Y, Gong Y, Favazza TL, Morss PC, Saba NJ, Fredrick TW, He X, Akula JD, Chen J. Pharmacologic Activation of Wnt Signaling by Lithium Normalizes Retinal Vasculature in a Murine Model of Familial Exudative Vitreoretinopathy. Am J Pathol. 2016 10; 186(10):2588-600. PMID: 27524797; PMCID: PMC5222984.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  14. Tanimoto N, Akula JD, Fulton AB, Weber BH, Seeliger MW. Differentiation of murine models of "negative ERG" by single and repetitive light stimuli. Doc Ophthalmol. 2016 Apr; 132(2):101-9. PMID: 26996188.
    Citations: 6     Fields:    Translation:AnimalsCells
  15. Ramamirtham R, Akula JD, Soni G, Swanson MJ, Bush JN, Moskowitz A, Swanson EA, Favazza TL, Tavormina JL, Mujat M, Ferguson RD, Hansen RM, Fulton AB. Extrafoveal Cone Packing in Eyes With a History of Retinopathy of Prematurity. Invest Ophthalmol Vis Sci. 2016 Feb; 57(2):467-75. PMID: 26868749; PMCID: PMC4758295.
    Citations: 5     Fields:    Translation:HumansCells
  16. Akula JD. Vigabatrin retinal toxicity in children with infantile spasms: An observational cohort study. Neurology. 2015 Aug 18; 85(7):655-6. PMID: 26283761.
    Citations: 1     Fields:    Translation:Humans
  17. Munro RJ, Fulton AB, Chui TY, Moskowitz A, Ramamirtham R, Hansen RM, Prabhu SP, Akula JD. Eye growth in term- and preterm-born eyes modeled from magnetic resonance images. Invest Ophthalmol Vis Sci. 2015 May; 56(5):3121-31. PMID: 26024095; PMCID: PMC5963310.
    Citations: 8     Fields:    Translation:Humans
  18. Akula JD, Noonan ER, Di Nardo A, Favazza TL, Zhang N, Sahin M, Hansen RM, Fulton AB. Vigabatrin can enhance electroretinographic responses in pigmented and albino rats. Doc Ophthalmol. 2015 Aug; 131(1):1-11. PMID: 25761928.
    Citations: 2     Fields:    Translation:AnimalsCells
  19. Zhang N, Favazza TL, Baglieri AM, Benador IY, Noonan ER, Fulton AB, Hansen RM, Iuvone PM, Akula JD. The rat with oxygen-induced retinopathy is myopic with low retinal dopamine. Invest Ophthalmol Vis Sci. 2013 Dec 19; 54(13):8275-84. PMID: 24168993.
    Citations: 14     Fields:    Translation:AnimalsCells
  20. Griffith RM, Li H, Zhang N, Favazza TL, Fulton AB, Hansen RM, Akula JD. Next-generation sequencing analysis of gene regulation in the rat model of retinopathy of prematurity. Doc Ophthalmol. 2013 Aug; 127(1):13-31. PMID: 23775346.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  21. Favazza TL, Tanimoto N, Munro RJ, Beck SC, Garcia Garrido M, Seide C, Sothilingam V, Hansen RM, Fulton AB, Seeliger MW, Akula JD. Alterations of the tunica vasculosa lentis in the rat model of retinopathy of prematurity. Doc Ophthalmol. 2013 Aug; 127(1):3-11. PMID: 23748796.
    Citations: 6     Fields:    Translation:HumansAnimals
  22. Hammer DX, Ferguson RD, Mujat M, Patel A, Plumb E, Iftimia N, Chui TY, Akula JD, Fulton AB. Multimodal adaptive optics retinal imager: design and performance. J Opt Soc Am A Opt Image Sci Vis. 2012 Dec 01; 29(12):2598-607. PMID: 23455909.
    Citations: 28     Fields:    Translation:HumansAnimals
  23. Park J, Zhang Y, Vykhodtseva N, Akula JD, McDannold NJ. Targeted and reversible blood-retinal barrier disruption via focused ultrasound and microbubbles. PLoS One. 2012; 7(8):e42754. PMID: 22912733.
    Citations: 16     Fields:    Translation:Animals
  24. Sapieha P, Chen J, Stahl A, Seaward MR, Favazza TL, Juan AM, Hatton CJ, Joyal JS, Krah NM, Dennison RJ, Tang J, Kern TS, Akula JD, Smith LE. Omega-3 polyunsaturated fatty acids preserve retinal function in type 2 diabetic mice. Nutr Diabetes. 2012 Jul 23; 2:e36. PMID: 23448719.
    Citations: 28     Fields:    
  25. Chui TY, Bissig D, Berkowitz BA, Akula JD. Refractive Development in the "ROP Rat". J Ophthalmol. 2012; 2012:956705. PMID: 22482037.
    Citations: 15     
  26. Blom JJ, Giove TJ, Favazza TL, Akula JD, Eldred WD. Inhibition of the adrenomedullin/nitric oxide signaling pathway in early diabetic retinopathy. J Ocul Biol Dis Infor. 2011 Jun; 4(1-2):70-82. PMID: 23316263.
    Citations: 2     
  27. Akula JD, Esdaille TM, Caffé AR, Naarendorp F. The scotopic electroretinogram of the sugar glider related to histological features of its retina. J Comp Physiol A Neuroethol Sens Neural Behav Physiol. 2011 Nov; 197(11):1043-54. PMID: 21744008.
    Citations:    Fields:    Translation:Animals
  28. Stahl A, Chen J, Sapieha P, Seaward MR, Krah NM, Dennison RJ, Favazza T, Bucher F, Löfqvist C, Ong H, Hellström A, Chemtob S, Akula JD, Smith LE. Postnatal weight gain modifies severity and functional outcome of oxygen-induced proliferative retinopathy. Am J Pathol. 2010 Dec; 177(6):2715-23. PMID: 21056995; PMCID: PMC2993262.
    Citations: 41     Fields:    Translation:HumansAnimals
  29. Benny O, Nakai K, Yoshimura T, Bazinet L, Akula JD, Nakao S, Hafezi-Moghadam A, Panigrahy D, Pakneshan P, D'Amato RJ. Broad spectrum antiangiogenic treatment for ocular neovascular diseases. PLoS One. 2010 Sep 01; 5(9). PMID: 20824139.
    Citations: 10     Fields:    Translation:HumansAnimals
  30. Akula JD, Hansen RM, Tzekov R, Favazza TL, Vyhovsky TC, Benador IY, Mocko JA, McGee D, Kubota R, Fulton AB. Visual cycle modulation in neurovascular retinopathy. Exp Eye Res. 2010 Aug; 91(2):153-61. PMID: 20430026.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  31. Akula JD, Favazza TL, Mocko JA, Benador IY, Asturias AL, Kleinman MS, Hansen RM, Fulton AB. The anatomy of the rat eye with oxygen-induced retinopathy. Doc Ophthalmol. 2010 Feb; 120(1):41-50. PMID: 19820974.
    Citations: 17     Fields:    Translation:HumansAnimals
  32. Fulton AB, Hansen RM, Moskowitz A, Akula JD. The neurovascular retina in retinopathy of prematurity. Prog Retin Eye Res. 2009 Nov; 28(6):452-82. PMID: 19563909.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  33. Akula JD, Mocko JA, Benador IY, Hansen RM, Favazza TL, Vyhovsky TC, Fulton AB. The neurovascular relation in oxygen-induced retinopathy. Mol Vis. 2008; 14:2499-508. PMID: 19112532.
    Citations: 32     Fields:    Translation:AnimalsCells
  34. Moskowitz A, Hansen RM, Akula JD, Eklund SE, Fulton AB. Rod and rod-driven function in achromatopsia and blue cone monochromatism. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):950-8. PMID: 18824728; PMCID: PMC2631615.
    Citations: 13     Fields:    Translation:HumansCells
  35. Fulton AB, Akula JD, Mocko JA, Hansen RM, Benador IY, Beck SC, Fahl E, Seeliger MW, Moskowitz A, Harris ME. Retinal degenerative and hypoxic ischemic disease. Doc Ophthalmol. 2009 Feb; 118(1):55-61. PMID: 18483822.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  36. Akula JD, Mocko JA, Moskowitz A, Hansen RM, Fulton AB. The oscillatory potentials of the dark-adapted electroretinogram in retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5788-97. PMID: 18055833.
    Citations: 41     Fields:    Translation:HumansAnimals
  37. Akula JD, Hansen RM, Martinez-Perez ME, Fulton AB. Rod photoreceptor function predicts blood vessel abnormality in retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2007 Sep; 48(9):4351-9. PMID: 17724227.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  38. Hansen RM, Eklund SE, Benador IY, Mocko JA, Akula JD, Liu Y, Martinez-Perez ME, Fulton AB. Retinal degeneration in children: dark adapted visual threshold and arteriolar diameter. Vision Res. 2008 Feb; 48(3):325-31. PMID: 17765282; PMCID: PMC2476928.
    Citations: 8     Fields:    Translation:Humans
  39. Liu K, Akula JD, Hansen RM, Moskowitz A, Kleinman MS, Fulton AB. Development of the electroretinographic oscillatory potentials in normal and ROP rats. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5447-52. PMID: 17122135.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  40. Liu K, Akula JD, Falk C, Hansen RM, Fulton AB. The retinal vasculature and function of the neural retina in a rat model of retinopathy of prematurity. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2639-47. PMID: 16723481.
    Citations: 48     Fields:    Translation:HumansAnimals
  41. Akula JD, Lyubarsky AL, Naarendorp F. The sensitivity and spectral identity of the cones driving the b-wave of the rat electroretinogram. Vis Neurosci. 2003 Mar-Apr; 20(2):109-17. PMID: 12916733.
    Citations: 9     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.