Harvard Catalyst Profiles

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Ayellet Vered Segre, Ph.D.

Title
Institution
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Biography
education and training
Hebrew University of Jerusalem, IsraelB.Sc.1998Life Sciences
Weizmann Institute of Science, IsraelM.Sc.2001Cancer Research
Harvard University, Cambridge, MAPh.D.2007Genetics and Genomics
Massachusetts General Hospital (MGH) and Broad Institute of Harvard and MIT, Cambridge, MAPostdoctoral training2013Genomics of Complex Diseases

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. Genetic Analysis, Jaeb Center for Health Research (Segre, Ayellet V.) Sep 1, 2020 - Aug 31, 2022
    NIH/NEI
    DRCR Retina Network Study of Pharmacogenetics of Treatment Response and Diabetic Retinopathy Severity
    Role Description: The goal of this project is to perform pharmacogenetic analyses for treatment response to anti-Vascular Endothelial Growth Factor injections in diabetic retinopathy and macular edema.
    Role: Principal Investigator
  2. R01 EY031424-01 (Segrè, Ayellet V.) Jun 1, 2020 - May 31, 2025
    NIH/NEI
    Uncovering Novel Biological Processes and Pathogenic Mechanisms for Glaucoma
    Role Description: The goal of this project is to generate transcriptome, genetic regulation of gene expression (e/sQTLs), and open chromatin maps in glaucoma-relevant human ocular tissues, and combine this functional genomics resource with genome-wide association studies and pathway information to gain new insights into the causal mechanisms of glaucoma. We will build a web-based platform for sharing, browsing, and exploring our ocular expression and regulation data in relation to genetic associations with glaucoma and other eye diseases.
    Role: Principal Investigator
  3. CZI Seed Networks Grant for Human Cell Atlas (J. Sanes, A.V. Segrè, T. Blancalani, G. Hageman, D. Juric, T. van Zyl) Jul 1, 2019 - Jun 30, 2022
    Chan Zuckerberg Initiative (CZI)
    Cell Atlas of the Human Eye from Birth to Old Age
    Role Description: The goal of the project is to use single cell and single nucleus RNA-sequencing and computational analyses to generate a comprehensive reference atlas of the various cell types in the human eye in different age groups, and a map of the transcriptome and genetic regulation of gene expression in the different ocular cell types.
    Role: Co-Principal Investigator

Bibliographic
selected publications
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© 2023 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.