Harvard Catalyst Profiles

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Ayellet Vered Segre, Ph.D.

Title
Institution
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Biography
education and training
Hebrew University of Jerusalem, IsraelB.Sc.1998Life Sciences
Weizmann Institute of Science, IsraelM.Sc.2001Cancer Research
Harvard University, Cambridge, MAPh.D.2007Genetics and Genomics
Massachusetts General Hospital (MGH) and Broad Institute of Harvard and MIT, Cambridge, MAPostdoctoral training2013Genomics of Complex Diseases
awards and honors
2024 - 2025
Research to Prevent Blindness, Career Advancement Award

Overview

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. RPB Career advancement award (Segrè, Ayellet V.) Jan 1, 2024 - Dec 31, 2025
    Research to Prevent Blindness / The Glaucoma Foundation
    Integrating cell type-specific genetic regulation in the outflow pathway, retina and optic nerve head with genetic associations to uncover causal mechanisms for glaucoma
    Role Description: The goals of this grant are to identify allele-specific expression at cell type resolution in glaucoma-relevant eye tissues, through analysis of single-nucleus RNA-sequencing data of the aqueous humor outflow pathways, retina and optic nerve head, and whole genome sequencing of the donors’ DNA, to perform single cell epigenomic and transcriptomic profiling of optic nerve head samples to identify transcriptionally active genomic regions in optic nerve head cell types, and to integrate these results with primary open angle glaucoma and intraocular pressure genetic associations to identify regulatory mechanisms, genes and cell types that contribute to glaucoma.
    Role: Principal Investigator
  2. 1U01HL166060-01 (Segre, Ayellet V., Gupta, Rajat)) Jul 1, 2022
    NIH/NHGRI
    Identifying the organotypic and disease-specific vascular cell populations by integrating single cell data with polygenic risk
    Role Description: The goals of this grant are to perform single cell RNA-sequencing (scRNA-seq) of diseased vascular tissues (Gupta) and to generate and apply novel computational and statistical methods that integrate scRNA-seq data from diseased and healthy tissues from the Human Biomolecular Atlas Program (HuBMAP) with genome-wide association study data of polygenic diseases to identify disease-relevant cell populations and cell type-specific gene programs (Segrè), with a focus on vascular diseases and cell types.
    Role: Co-Principal Investigator
  3. Genetic Analysis, Jaeb Center for Health Research (Segre, Ayellet V.) Sep 1, 2020 - Feb 29, 2024
    NIH/NEI
    DRCR Retina Network Study of Pharmacogenetics of Treatment Response and Diabetic Retinopathy Severity
    Role Description: The goal of this project is to perform pharmacogenetic analyses for treatment response to anti-Vascular Endothelial Growth Factor injections in diabetic retinopathy and macular edema.
    Role: Principal Investigator
  4. R01 EY031424-01 (Segrè, Ayellet V.) Jun 1, 2020 - May 31, 2025
    NIH/NEI
    Uncovering Novel Biological Processes and Pathogenic Mechanisms for Glaucoma
    Role Description: The goal of this project is to generate transcriptome, genetic regulation of gene expression (e/sQTLs), and open chromatin maps in glaucoma-relevant human ocular tissues, and combine this functional genomics resource with genome-wide association studies and pathway information to gain new insights into the causal mechanisms of glaucoma. We will build a web-based platform for sharing, browsing, and exploring our ocular expression and regulation data in relation to genetic associations with glaucoma and other eye diseases.
    Role: Principal Investigator
  5. CZI Seed Networks Grant for Human Cell Atlas (J. Sanes, A.V. Segrè, T. Blancalani, G. Hageman, D. Juric, T. van Zyl) Jul 1, 2019 - Jun 30, 2023
    Chan Zuckerberg Initiative (CZI)
    Cell Atlas of the Human Eye from Birth to Old Age
    Role Description: The goal of the project is to use single cell and single nucleus RNA-sequencing and computational analyses to generate a comprehensive reference atlas of the various cell types in the human eye in different age groups, and a map of the transcriptome and genetic regulation of gene expression in the different ocular cell types.
    Role: Co-Principal Investigator

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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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© 2024 President and Fellows of Harvard College
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.