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Pritha Sen, M.D.

Title
Institution
Department
Address
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Biography
education and training
Harvard University2001AB, Biology and Women's Studies
Harvard Medical School2008MD
Massachusetts General Hospital2011Internal Medicine Residency
Massachusetts General Hospital and Brigham and Women's Hospital2012Infectious Diseases Fellowship
Massachusetts General Hospital2013Chief Resident in Medicine
Massachusetts General Hospital2014Transplant and Immunocompromised Host Infectious Diseases Fellowship

Research
research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
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  1. K08HL157725 (SEN, PRITHA) Apr 1, 2021 - Mar 31, 2026
    NIH/NHLBI
    High dimensional single-cell mapping to define immune signatures of cytomegalovirus-associated rejection in cardiac transplantation
    Role: Principal Investigator

Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Blum SM, Zlotoff DA, Smith NP, Kernin IJ, Ramesh S, Zubiri L, Caplin J, Samanta N, Martin S, Wang M, Tirard A, Song Y, Xu KH, Barth J, Sen P, Slowikowski K, Tantivit J, Manakongtreecheep K, Arnold BY, Nasrallah M, Pinto CJ, McLoughlin D, Jackson M, Chan P, Lawless A, Michaud WA, Sharova T, Nieman LT, Gainor JF, Wu CJ, Juric D, Mino-Kenudson M, Oliveira G, Sullivan RJ, Boland GM, Stone JR, Thomas MF, Neilan TG, Reynolds KL, Villani AC. Immune responses in checkpoint myocarditis across heart, blood and tumour. Nature. 2024 Dec; 636(8041):215-223. PMID: 39506125.
    Citations:
    Fields: SciScienceTranslation:HumansCells
  2. Oh DS, Kim E, Normand R, Lu G, Shook LL, Lyall A, Jasset O, Demidkin S, Gilbert E, Kim J, Akinwunmi B, Tantivit J, Tirard A, Arnold BY, Slowikowski K, MGH COVID-19 Collection & Processing Team, Goldberg MB, Filbin MR, Hacohen N, Nguyen LH, Chan AT, Yu XG, Li JZ, Yonker L, Fasano A, Perlis RH, Pasternak O, Gray KJ, Choi GB, Drew DA, Sen P, Villani AC, Edlow AG, Huh JR. SARS-CoV-2 infection elucidates features of pregnancy-specific immunity. Cell Rep. 2024 Nov 26; 43(11):114933. PMID: 39504241; PMCID: PMC11724703.
    Citations:
    Fields: CelCell BiologyMolMolecular BiologyTranslation:HumansCells
  3. Harding AT, Crossen AJ, Reedy JL, Basham KJ, Hepworth OW, Zhang Y, Shah VS, Harding HB, Surve MV, Simaku P, Kwaku GN, Jensen KN, Otto Y, Ward RA, Thompson GR, Klein BS, Rajagopal J, Sen P, Haber AL, Vyas JM. Single-cell analysis of human airway epithelium identifies cell type-specific responses to Aspergillus and Coccidioides. bioRxiv. 2024 Sep 13. PMID: 39314271; PMCID: PMC11418999.
    Citations: 1
  4. Thomas MF, Slowikowski K, Manakongtreecheep K, Sen P, Samanta N, Tantivit J, Nasrallah M, Zubiri L, Smith NP, Tirard A, Ramesh S, Arnold BY, Nieman LT, Chen JH, Eisenhaure T, Pelka K, Song Y, Xu KH, Jorgji V, Pinto CJ, Sharova T, Glasser R, Chan P, Sullivan RJ, Khalili H, Juric D, Boland GM, Dougan M, Hacohen N, Li B, Reynolds KL, Villani AC. Single-cell transcriptomic analyses reveal distinct immune cell contributions to epithelial barrier dysfunction in checkpoint inhibitor colitis. Nat Med. 2024 May; 30(5):1349-1362. PMID: 38724705; PMCID: PMC11673812.
    Citations: 4
    Fields: MedMedicine (General)MolMolecular Biology
  5. Burwick RM, Yawetz S, Stephenson KE, Collier AY, Sen P, Blackburn BG, Kojic EM, Hirshberg A, Suarez JF, Sobieszczyk ME, Marks KM, Mazur S, Big C, Manuel O, Morlin G, Rose SJ, Naqvi M, Goldfarb IT, DeZure A, Telep L, Tan SK, Zhao Y, Hahambis T, Hindman J, Chokkalingam AP, Carter C, Das M, Osinusi AO, Brainard DM, Varughese TA, Kovalenko O, Sims MD, Desai S, Swamy G, Sheffield JS, Zash R, Short WR. Compassionate Use of Remdesivir in Pregnant Women With Severe Coronavirus Disease 2019. Clin Infect Dis. 2021 12 06; 73(11):e3996-e4004. PMID: 33031500; PMCID: PMC7797739.
    Citations: 65
    Fields: ComCommunicable DiseasesTranslation:HumansCells
  6. Normandin E, Holroyd KB, Collens SI, Shaw BM, Siddle KJ, Adams G, Rudy M, Solomon IH, Anahtar MN, Lemieux JE, Trombetta BA, Kivisakk P, Arnold SE, Rapalino O, Piantadosi AL, Sen P, Rosenberg ES, Branda J, Sabeti PC, Mukerji SS. Intrathecal inflammatory responses in the absence of SARS-CoV-2 nucleic acid in the CSF of COVID-19 hospitalized patients. J Neurol Sci. 2021 Nov 15; 430:120023. PMID: 34678659; PMCID: PMC8489278.
    Citations: 16
    Fields: NeuNeurologyTranslation:HumansCells
  7. Ward RA, Aghaeepour N, Bhattacharyya RP, Clish CB, Gaudillière B, Hacohen N, Mansour MK, Mudd PA, Pasupneti S, Presti RM, Rhee EP, Sen P, Spec A, Tam JM, Villani AC, Woolley AE, Hsu JL, Vyas JM. Harnessing the Potential of Multiomics Studies for Precision Medicine in Infectious Disease. Open Forum Infect Dis. 2021 Nov; 8(11):ofab483. PMID: 34805429; PMCID: PMC8598922.
    Citations: 9
  8. Mohareb AM, Rosenberg JM, Bhattacharyya RP, Kotton CN, Chu JT, Jilg N, Hysell KM, Albin JS, Sen P, Bloom SM, Schiff AE, Zachary KC, Letourneau AR, Kim AY, Hurtado RM. Preventing Infectious Complications of Immunomodulation in COVID-19 in Foreign-Born Patients. J Immigr Minor Health. 2021 Dec; 23(6):1343-1347. PMID: 34159495; PMCID: PMC8218971.
    Citations: 2
    Fields: PubPublic HealthSocSocial SciencesTranslation:HumansCellsPHPublic Health
  9. Meyerowitz EA, Sen P, Schoenfeld SR, Neilan TG, Frigault MJ, Stone JH, Kim AY, Mansour MK. Immunomodulation as Treatment for Severe Coronavirus Disease 2019: A Systematic Review of Current Modalities and Future Directions. Clin Infect Dis. 2021 06 15; 72(12):e1130-e1143. PMID: 33216852; PMCID: PMC7717185.
    Citations: 28
    Fields: ComCommunicable DiseasesTranslation:HumansCells
  10. Delorey TM, Ziegler CGK, Heimberg G, Normand R, Yang Y, Segerstolpe Å, Abbondanza D, Fleming SJ, Subramanian A, Montoro DT, Jagadeesh KA, Dey KK, Sen P, Slyper M, Pita-Juárez YH, Phillips D, Biermann J, Bloom-Ackermann Z, Barkas N, Ganna A, Gomez J, Melms JC, Katsyv I, Normandin E, Naderi P, Popov YV, Raju SS, Niezen S, Tsai LT, Siddle KJ, Sud M, Tran VM, Vellarikkal SK, Wang Y, Amir-Zilberstein L, Atri DS, Beechem J, Brook OR, Chen J, Divakar P, Dorceus P, Engreitz JM, Essene A, Fitzgerald DM, Fropf R, Gazal S, Gould J, Grzyb J, Harvey T, Hecht J, Hether T, Jané-Valbuena J, Leney-Greene M, Ma H, McCabe C, McLoughlin DE, Miller EM, Muus C, Niemi M, Padera R, Pan L, Pant D, Pe'er C, Pfiffner-Borges J, Pinto CJ, Plaisted J, Reeves J, Ross M, Rudy M, Rueckert EH, Siciliano M, Sturm A, Todres E, Waghray A, Warren S, Zhang S, Zollinger DR, Cosimi L, Gupta RM, Hacohen N, Hibshoosh H, Hide W, Price AL, Rajagopal J, Tata PR, Riedel S, Szabo G, Tickle TL, Ellinor PT, Hung D, Sabeti PC, Novak R, Rogers R, Ingber DE, Jiang ZG, Juric D, Babadi M, Farhi SL, Izar B, Stone JR, Vlachos IS, Solomon IH, Ashenberg O, Porter CBM, Li B, Shalek AK, Villani AC, Rozenblatt-Rosen O, Regev A. COVID-19 tissue atlases reveal SARS-CoV-2 pathology and cellular targets. Nature. 2021 07; 595(7865):107-113. PMID: 33915569; PMCID: PMC8919505.
    Citations: 369
    Fields: SciScienceTranslation:HumansCells
  11. Conklin J, Frosch MP, Mukerji SS, Rapalino O, Maher MD, Schaefer PW, Lev MH, Gonzalez RG, Das S, Champion SN, Magdamo C, Sen P, Harrold GK, Alabsi H, Normandin E, Shaw B, Lemieux JE, Sabeti PC, Branda JA, Brown EN, Westover MB, Huang SY, Edlow BL. Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19. J Neurol Sci. 2021 02 15; 421:117308. PMID: 33497950; PMCID: PMC7832284.
    Citations: 54
    Fields: NeuNeurologyTranslation:HumansCTClinical Trials
  12. Bogorodskaya M, Lyass A, Mahoney TF, Borowsky LH, Sen P, Swirski FK, Srinivasa S, Longenecker CT, Massaro JM, D'Agostino RB, Triant VA. Utilization of absolute monocyte counts to predict cardiovascular events in people living with HIV. HIV Med. 2021 04; 22(4):314-320. PMID: 33295150; PMCID: PMC7954843.
    Citations: 3
    Fields: AcqAcquired Immunodeficiency SyndTranslation:HumansCells
  13. Stone JH, Frigault MJ, Serling-Boyd NJ, Fernandes AD, Harvey L, Foulkes AS, Horick NK, Healy BC, Shah R, Bensaci AM, Woolley AE, Nikiforow S, Lin N, Sagar M, Schrager H, Huckins DS, Axelrod M, Pincus MD, Fleisher J, Sacks CA, Dougan M, North CM, Halvorsen YD, Thurber TK, Dagher Z, Scherer A, Wallwork RS, Kim AY, Schoenfeld S, Sen P, Neilan TG, Perugino CA, Unizony SH, Collier DS, Matza MA, Yinh JM, Bowman KA, Meyerowitz E, Zafar A, Drobni ZD, Bolster MB, Kohler M, D'Silva KM, Dau J, Lockwood MM, Cubbison C, Weber BN, Mansour MK, BACC Bay Tocilizumab Trial Investigators. Efficacy of Tocilizumab in Patients Hospitalized with Covid-19. N Engl J Med. 2020 12 10; 383(24):2333-2344. PMID: 33085857; PMCID: PMC7646626.
    Citations: 775
    Fields: MedMedicine (General)Translation:Humans
  14. Sen P, Wilkie AR, Ji F, Yang Y, Taylor IJ, Velazquez-Palafox M, Vanni EAH, Pesola JM, Fernandez R, Chen H, Morsett LM, Abels ER, Piper M, Lane RJ, Hickman SE, Means TK, Rosenberg ES, Sadreyev RI, Li B, Coen DM, Fishman JA, El Khoury J. Linking indirect effects of cytomegalovirus in transplantation to modulation of monocyte innate immune function. Sci Adv. 2020 04; 6(17):eaax9856. PMID: 32494628; PMCID: PMC7176434.
    Citations: 11
    Fields: SciScience
  15. Maas SLN, Abels ER, Van De Haar LL, Zhang X, Morsett L, Sil S, Guedes J, Sen P, Prabhakar S, Hickman SE, Lai CP, Ting DT, Breakefield XO, Broekman MLD, El Khoury J. Glioblastoma hijacks microglial gene expression to support tumor growth. J Neuroinflammation. 2020 Apr 16; 17(1):120. PMID: 32299465.
    Citations: 55
    Fields: NeuNeurologyTranslation:AnimalsCells
  16. Hickman S, Izzy S, Sen P, Morsett L, El Khoury J. Microglia in neurodegeneration. Nat Neurosci. 2018 10; 21(10):1359-1369. PMID: 30258234.
    Citations: 704
    Fields: NeuNeurologyTranslation:HumansAnimalsCells
  17. Hulot SL, Seaman MS, Sen P, Autissier PA, Manuel ER, Letvin NL. Diverse cross-reactive potential and Vbeta gene usage of an epitope-specific cytotoxic T-lymphocyte population in monkeys immunized with diverse human immunodeficiency virus type 1 Env immunogens. J Virol. 2009 Oct; 83(19):9803-12. PMID: 19640988.
    Citations:
    Fields: VirVirologyTranslation:AnimalsCells
  18. Sen P, Charini WA, Subbramanian RA, Manuel ER, Kuroda MJ, Autissier PA, Letvin NL. Clonal focusing of epitope-specific CD8+ T lymphocytes in rhesus monkeys following vaccination and simian-human immunodeficiency virus challenge. J Virol. 2008 Jan; 82(2):805-16. PMID: 17977967.
    Citations: 4
    Fields: VirVirologyTranslation:AnimalsCells
  19. Hasegawa A, Moriya C, Liu H, Charini WA, Vinet HC, Subbramanian RA, Sen P, Letvin NL, Kuroda MJ. Analysis of TCRalphabeta combinations used by simian immunodeficiency virus-specific CD8+ T cells in rhesus monkeys: implications for CTL immunodominance. J Immunol. 2007 Mar 15; 178(6):3409-17. PMID: 17339435.
    Citations: 8
    Fields: AllAllergy and ImmunologyTranslation:AnimalsCells
  20. Manuel ER, Charini WA, Sen P, Peyerl FW, Kuroda MJ, Schmitz JE, Autissier P, Sheeter DA, Torbett BE, Letvin NL. Contribution of T-cell receptor repertoire breadth to the dominance of epitope-specific CD8+ T-lymphocyte responses. J Virol. 2006 Dec; 80(24):12032-40. PMID: 17035327; PMCID: PMC1676269.
    Citations: 14
    Fields: VirVirologyTranslation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.