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Bakhos A. Tannous, Ph.D.

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Biography
University of Windsor, Windsor, CanadaPh.D.06/2002Clinical Chemistry
Massachusetts General Hospital and Harvard Medical School, Boston, MAPost-doctoral Fellowship2005Molecular Imaging, Experimental Therapeutics
Massachusetts General Hospital and Harvard Medical School, Boston, MAFellowship2007Clinical Chemistry
1997
Overall Best Presentation Award
1997
Undergraduate Travel Award
1998
Conference Travel Award
1998
Young Investigator Award
2004
Young Investigator Award
2005
Research Award
2005
Young Investigator Award
2006
Alexis Bross Chair of Research
2006
Young Investigator Award
2007
Howard Temin Pathway to Independence Award in cancer research
2010
Outstanding Young Investigator Award
2012
Partners in Excellence Award Leadership and Innovation
2014
Partners in Excellence Award Continuous Research Operations Improvement Team Leadership and Innovati
2017
Innovation Discovery Award

Overview
Glioblastomas (GBMs) comprise >50% of all primary brain tumors and are the most malignant type, with a median survival of 14 months and 90% of patients dying within 5 years. Effective treatment is hindered by our limited understanding of disease progression as well as complications such as resistance to existing drugs. The goal of the Tannous lab is therefore to understand the mechanisms underlying GBM progression and therapeutic resistance and to develop novel diagnostics and therapeutics. Specifically, the group is developing ways to better target GBM stem cells, the subpopulation of GBM cells that is largely responsible for tumor resistance and recurrence; it is studying the signals that tumor cells can send to their surrounding to promote tumor expansion; and it is developing blood-based tests and biomarkers to detect brain tumors and monitor disease progression. The resulting technologies and therapies can also be extended to other cancer types, and the Tannous lab is exploring such applications in collaboration with other groups.

Mentoring
Available: 06/26/17, Expires: 06/19/21

Gliomas account for about 60% of all primary CNS tumors. Glioblastoma (GBM) or grade IV gliomas which comprise 50.9% of all gliomas are the most malignant form. Glioblastoma tumors are highly heterogeneous and there is a complex interaction among different types of tumor cells and stromal cells within the tumor. Recently it has been shown that the majority of tumor cells do not have the capacity to recapitulate a phenocopy of the original tumor and that only a small subpopulation of cells in the tumor, called cancer stem cells, have that ability upon xenotransplantation in nude mice. These cancer stem cells appear to be more resistant to conventional therapy, like chemotherapy and radiation, as compared to the non-cancer stem cells. Following current therapy for high-grade glioma tumors, most patients die within a year from a new secondary tumor foci forming within one centimeter of the resected area. These foci are enriched for cancer stem cells, and it is likely that they are responsible for tumor recurrence.

Our proposal focuses on (1) understanding the role of glioma stem cells in tumor/metastasis formation and therapeutic resistance, (2) developing novel therapeutic strategies to eradicate these cells. These hypothesis will be tested in both adult and pediatric high-grade glioma models.

Students would help the post-doctoral fellow in performing in culture as well as in vivo work related to this project.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS113816 (TANNOUS, BAKHOS A) Aug 1, 2020 - Jul 31, 2022
    NIH/NINDS
    Novel diffuse intrinsic pontine glioma therapy
    Role: Principal Investigator
  2. R21NS111922 (TANNOUS, BAKHOS A) Dec 1, 2019 - Nov 30, 2021
    NIH/NINDS
    Radiation-induced targeted extracellular vesicles -based gene delivery for glioma therapy
    Role: Principal Investigator
  3. R01NS095647 (TANNOUS, BAKHOS A.) Apr 1, 2016 - Jan 31, 2019
    NIH/NINDS
    Screening for adjuvant gliobalstoma therapeutics
    Role: Principal Investigator
  4. R21NS095384 (TANNOUS, BAKHOS A) Sep 30, 2015 - Aug 31, 2017
    NIH/NINDS
    Blood-based assays for the detection of glioblastoma RNA biomarkers
    Role: Principal Investigator
  5. R21CA176359 (TANNOUS, BAKHOS A.) Jul 1, 2013 - Jun 30, 2015
    NIH/NCI
    Detection of NSCLC-derived mutant RNA in platelets
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wang J, Tannous BA, Poznansky MC, Chen H. CXCR4 antagonist AMD3100 (plerixafor): From an impurity to a therapeutic agent. Pharmacol Res. 2020 Jun 13; 159:105010. PMID: 32544428.
    Citations:    
  2. Narayan RS, Molenaar P, Teng J, Cornelissen FMG, Roelofs I, Menezes R, Dik R, Lagerweij T, Broersma Y, Petersen N, Marin Soto JA, Brands E, van Kuiken P, Lecca MC, Lenos KJ, In 't Veld SGJG, van Wieringen W, Lang FF, Sulman E, Verhaak R, Baumert BG, Stalpers LJA, Vermeulen L, Watts C, Bailey D, Slotman BJ, Versteeg R, Noske D, Sminia P, Tannous BA, Wurdinger T, Koster J, Westerman BA. A cancer drug atlas enables synergistic targeting of independent drug vulnerabilities. Nat Commun. 2020 06 10; 11(1):2935. PMID: 32523045.
    Citations:    
  3. Schweiger MW, Li M, Giovanazzi A, Fleming RL, Tabet EI, Nakano I, Würdinger T, Chiocca EA, Tian T, Tannous BA. Extracellular Vesicles Induce Mesenchymal Transition and Therapeutic Resistance in Glioblastomas through NF-?B/STAT3 Signaling. Adv Biosyst. 2020 Jun 09; e1900312. PMID: 32519463.
    Citations:    
  4. Badr CE, da Hora CC, Kirov AB, Tabet E, Amante R, Maksoud S, Nibbs AE, Fitzsimons E, Boukhali M, Chen JW, Chiu NHL, Nakano I, Haas W, Mazitschek R, Tannous BA. Obtusaquinone: A Cysteine-Modifying Compound That Targets Keap1 for Degradation. ACS Chem Biol. 2020 06 19; 15(6):1445-1454. PMID: 32338864.
    Citations:    
  5. Kompa AR, Greening DW, Kong AM, McMillan PJ, Fang H, Saxena R, Wong RCB, Lees JG, Sivakumaran P, Newcomb AE, Tannous BA, Kos C, Mariana L, Loudovaris T, Hausenloy DJ, Lim SY. Sustained subcutaneous delivery of secretome of human cardiac stem cells promotes cardiac repair following myocardial infarction. Cardiovasc Res. 2020 04 06. PMID: 32251516.
    Citations:    
  6. Yamashita D, Minata M, Ibrahim AN, Yamaguchi S, Coviello V, Bernstock JD, Harada S, Cerione RA, Tannous BA, La Motta C, Nakano I. Identification of ALDH1A3 as a Viable Therapeutic Target in Breast Cancer Metastasis-Initiating Cells. Mol Cancer Ther. 2020 05; 19(5):1134-1147. PMID: 32127468.
    Citations:    
  7. Fan S, Tian T, Lv X, Lei X, Yang Z, Liu M, Liang F, Li S, Lin X, Lin Z, Xie S, Li B, Chen W, Pan G, Lin X, Ou Z, Zhang Y, Peng Y, Xiao L, Zhang L, Sun S, Zhang H, Lin S, Li Q, Zeng B, Kontos F, Ruan Y, Ferrone S, Lin D, Tannous BA, Li J. lncRNA CISAL Inhibits BRCA1 Transcription by Forming a Tertiary Structure at Its Promoter. iScience. 2020 Feb 21; 23(2):100835. PMID: 32000125.
    Citations:    
  8. Zaborowski MP, Cheah PS, Zhang X, Bushko I, Lee K, Sammarco A, Zappulli V, Maas SLN, Allen RM, Rumde P, György B, Aufiero M, Schweiger MW, Lai CP, Weissleder R, Lee H, Vickers KC, Tannous BA, Breakefield XO. Membrane-bound Gaussia luciferase as a tool to track shedding of membrane proteins from the surface of extracellular vesicles. Sci Rep. 2019 11 22; 9(1):17387. PMID: 31758005.
    Citations:    
  9. Tannous BA, Badr CE. An allosteric inhibitor of SHP2 effectively targets PDGFRa-driven glioblastoma. Neuro Oncol. 2019 11 04; 21(11):1348-1349. PMID: 31616943.
    Citations:    
  10. da Hora CC, Schweiger MW, Wurdinger T, Tannous BA. Patient-Derived Glioma Models: From Patients to Dish to Animals. Cells. 2019 09 30; 8(10). PMID: 31574953.
    Citations:    
  11. Prabhakar S, Cheah PS, Zhang X, Zinter M, Gianatasio M, Hudry E, Bronson RT, Kwiatkowski DJ, Stemmer-Rachamimov A, Maguire CA, Sena-Esteves M, Tannous BA, Breakefield XO. Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1. Mol Ther Methods Clin Dev. 2019 Dec 13; 15:18-26. PMID: 31534984.
    Citations:    
  12. Chen W, Wang P, Lu Y, Jin T, Lei X, Liu M, Zhuang P, Liao J, Lin Z, Li B, Peng Y, Pan G, Lv X, Zhang H, Ou Z, Xie S, Lin X, Sun S, Ferrone S, Tannous BA, Ruan Y, Li J, Fan S. Decreased expression of mitochondrial miR-5787 contributes to chemoresistance by reprogramming glucose metabolism and inhibiting MT-CO3 translation. Theranostics. 2019; 9(20):5739-5754. PMID: 31534516.
    Citations:    
  13. Carvalho LA, Tannous BA. Olfactory ensheathing cells travel their natural nasal pathway to deliver therapeutics to brain tumors. Oncotarget. 2019 Jul 08; 10(43):4351-4353. PMID: 31320988.
    Citations:    
  14. da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE. Erratum: Author Correction: Sustained NF-?B-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition. Cell Death Discov. 2019; 5:103. PMID: 31240130.
    Citations:    
  15. Zaborowski MP, Lee K, Na YJ, Sammarco A, Zhang X, Iwanicki M, Cheah PS, Lin HY, Zinter M, Chou CY, Fulci G, Tannous BA, Lai CP, Birrer MJ, Weissleder R, Lee H, Breakefield XO. Methods for Systematic Identification of Membrane Proteins for Specific Capture of Cancer-Derived Extracellular Vesicles. Cell Rep. 2019 04 02; 27(1):255-268.e6. PMID: 30943406.
    Citations:    
  16. Erel-Akbaba G, Carvalho LA, Tian T, Zinter M, Akbaba H, Obeid PJ, Chiocca EA, Weissleder R, Kantarci AG, Tannous BA. Radiation-Induced Targeted Nanoparticle-Based Gene Delivery for Brain Tumor Therapy. ACS Nano. 2019 04 23; 13(4):4028-4040. PMID: 30916923.
    Citations:    
  17. Tannous BA, Badr CE. A TNF-NF-?B-STAT3 loop triggers resistance of glioma-stem-like cells to Smac mimetics while sensitizing to EZH2 inhibitors. Cell Death Dis. 2019 03 19; 10(4):268. PMID: 30890700.
    Citations:    
  18. Tian T, Lv X, Pan G, Lu Y, Chen W, He W, Lei X, Zhang H, Liu M, Sun S, Ou Z, Lin X, Cai L, He L, Tu Z, Wang X, Tannous BA, Ferrone S, Li J, Fan S. Long Noncoding RNA MPRL Promotes Mitochondrial Fission and Cisplatin Chemosensitivity via Disruption of Pre-miRNA Processing. Clin Cancer Res. 2019 06 15; 25(12):3673-3688. PMID: 30885939.
    Citations:    
  19. da Hora CC, Pinkham K, Carvalho L, Zinter M, Tabet E, Nakano I, Tannous BA, Badr CE. Sustained NF-?B-STAT3 signaling promotes resistance to Smac mimetics in Glioma stem-like cells but creates a vulnerability to EZH2 inhibition. Cell Death Discov. 2019; 5:72. PMID: 30854231.
    Citations:    
  20. Carvalho LA, Teng J, Fleming RL, Tabet EI, Zinter M, de Melo Reis RA, Tannous BA. Olfactory Ensheathing Cells: A Trojan Horse for Glioma Gene Therapy. J Natl Cancer Inst. 2019 03 01; 111(3):283-291. PMID: 30257000.
    Citations:    Fields:    
  21. Minata M, Audia A, Shi J, Lu S, Bernstock J, Pavlyukov MS, Das A, Kim SH, Shin YJ, Lee Y, Koo H, Snigdha K, Waghmare I, Guo X, Mohyeldin A, Gallego-Perez D, Wang J, Chen D, Cheng P, Mukheef F, Contreras M, Reyes JF, Vaillant B, Sulman EP, Cheng SY, Markert JM, Tannous BA, Lu X, Kango-Singh M, Lee LJ, Nam DH, Nakano I, Bhat KP. Phenotypic Plasticity of Invasive Edge Glioma Stem-like Cells in Response to Ionizing Radiation. Cell Rep. 2019 02 12; 26(7):1893-1905.e7. PMID: 30759398.
    Citations:    
  22. Fan S, Tian T, Chen W, Lv X, Lei X, Zhang H, Sun S, Cai L, Pan G, He L, Ou Z, Lin X, Wang X, Perez MF, Tu Z, Ferrone S, Tannous BA, Li J. Mitochondrial miRNA Determines Chemoresistance by Reprogramming Metabolism and Regulating Mitochondrial Transcription. Cancer Res. 2019 03 15; 79(6):1069-1084. PMID: 30659020.
    Citations:    Fields:    
  23. Teng J, Hejazi S, Hiddingh L, Carvalho L, de Gooijer MC, Wakimoto H, Barazas M, Tannous M, Chi AS, Noske DP, Wesseling P, Wurdinger T, Batchelor TT, Tannous BA. Recycling drug screen repurposes hydroxyurea as a sensitizer of glioblastomas to temozolomide targeting de novo DNA synthesis, irrespective of molecular subtype. Neuro Oncol. 2018 04 09; 20(5):642-654. PMID: 29099956.
    Citations:    Fields:    Translation:HumansAnimalsCells
  24. Castellanos-Rizaldos E, Grimm DG, Tadigotla V, Hurley J, Healy J, Neal PL, Sher M, Venkatesan R, Karlovich C, Raponi M, Krug A, Noerholm M, Tannous J, Tannous BA, Raez LE, Skog JK. Exosome-Based Detection of EGFR T790M in Plasma from Non-Small Cell Lung Cancer Patients. Clin Cancer Res. 2018 06 15; 24(12):2944-2950. PMID: 29535126.
    Citations: 2     Fields:    
  25. Berenguer J, Lagerweij T, Zhao XW, Dusoswa S, van der Stoop P, Westerman B, de Gooijer MC, Zoetemelk M, Zomer A, Crommentuijn MHW, Wedekind LE, López-López À, Giovanazzi A, Bruch-Oms M, van der Meulen-Muileman IH, Reijmers RM, van Kuppevelt TH, García-Vallejo JJ, van Kooyk Y, Tannous BA, Wesseling P, Koppers-Lalic D, Vandertop WP, Noske DP, van Beusechem VW, van Rheenen J, Pegtel DM, van Tellingen O, Wurdinger T. Glycosylated extracellular vesicles released by glioblastoma cells are decorated by CCL18 allowing for cellular uptake via chemokine receptor CCR8. J Extracell Vesicles. 2018; 7(1):1446660. PMID: 29696074.
    Citations:    
  26. Landeira BS, Santana TTDS, Araújo JAM, Tabet EI, Tannous BA, Schroeder T, Costa MR. Activity-Independent Effects of CREB on Neuronal Survival and Differentiation during Mouse Cerebral Cortex Development. Cereb Cortex. 2018 02 01; 28(2):538-548. PMID: 27999124.
    Citations: 4     Fields:    
  27. Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano. 2017 11 28; 11(11):11041-11046. PMID: 29053921.
    Citations: 2     Fields:    Translation:HumansCells
  28. Tian T, Zhang HX, He CP, Fan S, Zhu YL, Qi C, Huang NP, Xiao ZD, Lu ZH, Tannous BA, Gao J. Surface functionalized exosomes as targeted drug delivery vehicles for cerebral ischemia therapy. Biomaterials. 2018 Jan; 150:137-149. PMID: 29040874.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  29. Best MG, Sol N, In 't Veld SGJG, Vancura A, Muller M, Niemeijer AN, Fejes AV, Tjon Kon Fat LA, Huis In 't Veld AE, Leurs C, Le Large TY, Meijer LL, Kooi IE, Rustenburg F, Schellen P, Verschueren H, Post E, Wedekind LE, Bracht J, Esenkbrink M, Wils L, Favaro F, Schoonhoven JD, Tannous J, Meijers-Heijboer H, Kazemier G, Giovannetti E, Reijneveld JC, Idema S, Killestein J, Heger M, de Jager SC, Urbanus RT, Hoefer IE, Pasterkamp G, Mannhalter C, Gomez-Arroyo J, Bogaard HJ, Noske DP, Vandertop WP, van den Broek D, Ylstra B, Nilsson RJA, Wesseling P, Karachaliou N, Rosell R, Lee-Lewandrowski E, Lewandrowski KB, Tannous BA, de Langen AJ, Smit EF, van den Heuvel MM, Wurdinger T. Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets. Cancer Cell. 2017 08 14; 32(2):238-252.e9. PMID: 28810146.
    Citations: 16     Fields:    Translation:HumansCells
  30. Lagerweij T, Dusoswa SA, Negrean A, Hendrikx EML, de Vries HE, Kole J, Garcia-Vallejo JJ, Mansvelder HD, Vandertop WP, Noske DP, Tannous BA, Musters RJP, van Kooyk Y, Wesseling P, Zhao XW, Wurdinger T. Optical clearing and fluorescence deep-tissue imaging for 3D quantitative analysis of the brain tumor microenvironment. Angiogenesis. 2017 Nov; 20(4):533-546. PMID: 28699046.
    Citations: 2     Fields:    Translation:Animals
  31. Teng J, da Hora CC, Kantar RS, Nakano I, Wakimoto H, Batchelor TT, Chiocca EA, Badr CE, Tannous BA. Dissecting inherent intratumor heterogeneity in patient-derived glioblastoma culture models. Neuro Oncol. 2017 06 01; 19(6):820-832. PMID: 28062830.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  32. Lashgari G, Kantar RS, Tannous BA. Secreted Reporters for Monitoring Multiple Promoter Function. Methods Mol Biol. 2017; 1651:33-47. PMID: 28801898.
    Citations:    Fields:    Translation:HumansAnimalsCells
  33. Mandelblat-Cerf Y, Kim A, Burgess CR, Subramanian S, Tannous BA, Lowell BB, Andermann ML. Bidirectional Anticipation of Future Osmotic Challenges by Vasopressin Neurons. Neuron. 2017 Jan 04; 93(1):57-65. PMID: 27989461.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Tannous BA, Chiocca EA, Jacobs AH, Corey DP, Breakefield XO. Tannous et al. Respond. Mol Ther. 2009 Aug; 17(8):1311-1312. PMID: 28160907.
    Citations:    Fields:    
  35. Wong HA, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. Mol Ther. 2015 Jul; 23(7):1234-1247. PMID: 28142001.
    Citations:    
  36. Li A, Wu Y, Linnoila J, Pulli B, Wang C, Zeller M, Ali M, Lewandrowski GK, Li J, Tricot B, Keliher E, Wojtkiewicz GR, Fulci G, Feng X, Tannous BA, Yao Z, Chen JW. Surface biotinylation of cytotoxic T lymphocytes for in vivo tracking of tumor immunotherapy in murine models. Cancer Immunol Immunother. 2016 12; 65(12):1545-1554. PMID: 27722909.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  37. Garfield AS, Shah BP, Burgess CR, Li MM, Li C, Steger JS, Madara JC, Campbell JN, Kroeger D, Scammell TE, Tannous BA, Myers MG, Andermann ML, Krashes MJ, Lowell BB. Dynamic GABAergic afferent modulation of AgRP neurons. Nat Neurosci. 2016 12; 19(12):1628-1635. PMID: 27643429.
    Citations: 21     Fields:    Translation:AnimalsCells
  38. Crommentuijn MH, Kantar R, Noske DP, Vandertop WP, Badr CE, Würdinger T, Maguire CA, Tannous BA. Systemically administered AAV9-sTRAIL combats invasive glioblastoma in a patient-derived orthotopic xenograft model. Mol Ther Oncolytics. 2016; 3:16017. PMID: 27382645.
    Citations: 3     
  39. Lagerweij T, Hiddingh L, Biesmans D, Crommentuijn MH, Cloos J, Li XN, Kogiso M, Tannous BA, Vandertop WP, Noske DP, Kaspers GJ, Würdinger T, Hulleman E. A chemical screen for medulloblastoma identifies quercetin as a putative radiosensitizer. Oncotarget. 2016 Jun 14; 7(24):35776-35788. PMID: 26967057.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  40. Kantar RS, Lashgari G, Tabet EI, Lewandrowski GK, Carvalho LA, Tannous BA. Imaging Tumor Vascularity and Response to Anti-Angiogenic Therapy Using Gaussia Luciferase. Sci Rep. 2016 05 20; 6:26353. PMID: 27198044.
    Citations:    Fields:    Translation:HumansAnimalsCells
  41. Teplyuk NM, Uhlmann EJ, Gabriely G, Volfovsky N, Wang Y, Teng J, Karmali P, Marcusson E, Peter M, Mohan A, Kraytsberg Y, Cialic R, Chiocca EA, Godlewski J, Tannous B, Krichevsky AM. Therapeutic potential of targeting microRNA-10b in established intracranial glioblastoma: first steps toward the clinic. EMBO Mol Med. 2016 Mar 01; 8(3):268-87. PMID: 26881967.
    Citations: 12     Fields:    Translation:HumansAnimals
  42. Best MG, Sol N, Tannous BA, Wesseling P, Wurdinger T. Re: a Word of Caution on New and Revolutionary Diagnostic Tests. Cancer Cell. 2016 Feb 08; 29(2):143-4. PMID: 26859454.
    Citations:    Fields:    Translation:HumansCells
  43. Nilsson RJ, Karachaliou N, Berenguer J, Gimenez-Capitan A, Schellen P, Teixido C, Tannous J, Kuiper JL, Drees E, Grabowska M, van Keulen M, Heideman DA, Thunnissen E, Dingemans AM, Viteri S, Tannous BA, Drozdowskyj A, Rosell R, Smit EF, Wurdinger T. Rearranged EML4-ALK fusion transcripts sequester in circulating blood platelets and enable blood-based crizotinib response monitoring in non-small-cell lung cancer. Oncotarget. 2016 Jan 05; 7(1):1066-75. PMID: 26544515.
    Citations: 24     Fields:    Translation:HumansCells
  44. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Ait-Si-Ali S, Akematsu T, Akporiaye ET, Al-Rubeai M, Albaiceta GM, Albanese C, Albani D, Albert ML, Aldudo J, Algül H, Alirezaei M, Alloza I, Almasan A, Almonte-Beceril M, Alnemri ES, Alonso C, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Andrieu-Abadie N, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Baghdiguian S, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Bailly Y, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bánhegyi G, Bao H, Barbeau B, Barrachina MD, Barreiro E, Bartel B, Bartolomé A, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Batoko H, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beaulieu JF, Beck GR, Becker C, Beckham JD, Bédard PA, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Bénard G, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernard A, Bernard M, Bernassola F, Bertolotti A, Bess AS, Besteiro S, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bianchi MW, Biard-Piechaczyk M, Billes V, Bincoletto C, Bingol B, Bird SW, Bitoun M, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Böckler S, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Boman A, Bonaldo P, Bordi M, Bosch J, Botana LM, Botti J, Bou G, Bouché M, Bouchecareilh M, Boucher MJ, Boulton ME, Bouret SG, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady N, Braga VM, Brancolini C, Braus GH, Bravo-San Pedro JM, Brennan LA, Bresnick EH, Brest P, Bridges D, Bringer MA, Brini M, Brito GC, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Bruhat A, Brum PC, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burelle Y, Burke RE, Burmeister M, Bütikofer P, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Camougrand N, Campanella M, Campbell GR, Campbell M, Campello S, Candau R, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carlsson SR, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carrier A, Carroll B, Casas C, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Ceña V, Cenci S, Cerella C, Cervia D, Cetrullo S, Chaachouay H, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chevet E, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chowdhury K, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652.
    Citations: 867     Fields:    Translation:HumansAnimals
  45. Crommentuijn MH, Maguire CA, Niers JM, Vandertop WP, Badr CE, Würdinger T, Tannous BA. Intracranial AAV-sTRAIL combined with lanatoside C prolongs survival in an orthotopic xenograft mouse model of invasive glioblastoma. Mol Oncol. 2016 Apr; 10(4):625-34. PMID: 26708508.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  46. Kuijten MM, Hannah Degeling M, Chen JW, Wojtkiewicz G, Waterman P, Weissleder R, Azzi J, Nicolay K, Tannous BA. Multimodal targeted high relaxivity thermosensitive liposome for in vivo imaging. Sci Rep. 2015 Nov 27; 5:17220. PMID: 26610702.
    Citations:    Fields:    Translation:HumansAnimalsCells
  47. Kil KE, Poutiainen P, Zhang Z, Zhu A, Kuruppu D, Prabhakar S, Choi JK, Tannous BA, Brownell AL. Synthesis and evaluation of N-(methylthiophenyl)picolinamide derivatives as PET radioligands for metabotropic glutamate receptor subtype 4. Bioorg Med Chem Lett. 2016 Jan 01; 26(1):133-9. PMID: 26602273.
    Citations:    Fields:    Translation:AnimalsCells
  48. Jaykumar AB, Caceres PS, Sablaban I, Tannous BA, Ortiz PA. Real-time monitoring of NKCC2 endocytosis by total internal reflection fluorescence (TIRF) microscopy. Am J Physiol Renal Physiol. 2016 Jan 15; 310(2):F183-91. PMID: 26538436.
    Citations: 3     Fields:    Translation:AnimalsCells
  49. Best MG, Sol N, Kooi I, Tannous J, Westerman BA, Rustenburg F, Schellen P, Verschueren H, Post E, Koster J, Ylstra B, Ameziane N, Dorsman J, Smit EF, Verheul HM, Noske DP, Reijneveld JC, Nilsson RJA, Tannous BA, Wesseling P, Wurdinger T. RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics. Cancer Cell. 2015 Nov 09; 28(5):666-676. PMID: 26525104.
    Citations: 70     Fields:    Translation:HumansCells
  50. Poutiainen P, Kil KE, Zhang Z, Kuruppu D, Tannous B, Brownell AL. Co-operative binding assay for the characterization of mGlu4 allosteric modulators. Neuropharmacology. 2015 Oct; 97:142-8. PMID: 26025660.
    Citations: 1     Fields:    Translation:AnimalsCells
  51. Balaj L, Atai NA, Chen W, Mu D, Tannous BA, Breakefield XO, Skog J, Maguire CA. Heparin affinity purification of extracellular vesicles. Sci Rep. 2015 May 19; 5:10266. PMID: 25988257.
    Citations: 25     Fields:    Translation:HumansCells
  52. Lai CP, Kim EY, Badr CE, Weissleder R, Mempel TR, Tannous BA, Breakefield XO. Visualization and tracking of tumour extracellular vesicle delivery and RNA translation using multiplexed reporters. Nat Commun. 2015 May 13; 6:7029. PMID: 25967391.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  53. Garfield AS, Li C, Madara JC, Shah BP, Webber E, Steger JS, Campbell JN, Gavrilova O, Lee CE, Olson DP, Elmquist JK, Tannous BA, Krashes MJ, Lowell BB. A neural basis for melanocortin-4 receptor-regulated appetite. Nat Neurosci. 2015 Jun; 18(6):863-71. PMID: 25915476.
    Citations: 63     Fields:    Translation:AnimalsCells
  54. Wong HA, Fatimy RE, Onodera C, Wei Z, Yi M, Mohan A, Gowrisankaran S, Karmali P, Marcusson E, Wakimoto H, Stephens R, Uhlmann EJ, Song JS, Tannous B, Krichevsky AM. The Cancer Genome Atlas Analysis Predicts MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma. Mol Ther. 2015 Jul; 23(7):1234-1247. PMID: 25903473.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  55. van der Mijn JC, Sol N, Mellema W, Jimenez CR, Piersma SR, Dekker H, Schutte LM, Smit EF, Broxterman HJ, Skog J, Tannous BA, Wurdinger T, Verheul HM. Analysis of AKT and ERK1/2 protein kinases in extracellular vesicles isolated from blood of patients with cancer. J Extracell Vesicles. 2014; 3:25657. PMID: 25491250.
    Citations: 2     
  56. Teng J, Hejazi S, Badr CE, Tannous BA. Systemic anticancer neural stem cells in combination with a cardiac glycoside for glioblastoma therapy. Stem Cells. 2014 Aug; 32(8):2021-32. PMID: 24801379.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  57. O'Reilly M, Federoff HJ, Fong Y, Kohn DB, Patterson AP, Ahmed N, Asokan A, Boye SE, Crystal RG, De Oliveira S, Gargiulo L, Harper SQ, Ikeda Y, Jambou R, Montgomery M, Prograis L, Rosenthal E, Sterman DH, Vandenberghe LH, Zoloth L, Abedi M, Adair J, Adusumilli PS, Goins WF, Gray J, Monahan P, Popplewell L, Sena-Esteves M, Tannous B, Weber T, Wierda W, Gopal-Srivastava R, McDonald CL, Rosenblum D, Corrigan-Curay J. Gene therapy: charting a future course--summary of a National Institutes of Health Workshop, April 12, 2013. Hum Gene Ther. 2014 Jun; 25(6):488-97. PMID: 24773122.
    Citations: 5     Fields:    Translation:HumansAnimals
  58. Senol O, Schaaij-Visser TB, Erkan EP, Dorfer C, Lewandrowski G, Pham TV, Piersma SR, Peerdeman SM, Ströbel T, Tannous B, Saydam N, Slavc I, Knosp E, Jimenez CR, Saydam O. miR-200a-mediated suppression of non-muscle heavy chain IIb inhibits meningioma cell migration and tumor growth in vivo. Oncogene. 2015 Apr 02; 34(14):1790-8. PMID: 24858044.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  59. van Berge L, Hamilton EM, Linnankivi T, Uziel G, Steenweg ME, Isohanni P, Wolf NI, Krägeloh-Mann I, Brautaset NJ, Andrews PI, de Jong BA, al Ghamdi M, van Wieringen WN, Tannous BA, Hulleman E, Würdinger T, van Berkel CG, Polder E, Abbink TE, Struys EA, Scheper GC, van der Knaap MS. Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation: clinical and genetic characterization and target for therapy. Brain. 2014 Apr; 137(Pt 4):1019-29. PMID: 24566671.
    Citations: 10     Fields:    Translation:HumansCells
  60. Elman JS, Murray RC, Murray RM, Wang F, Shen K, Gao S, Conway KE, Yarmush ML, Tannous BA, Weissleder R, Parekkadan B. Pharmacokinetics of natural and engineered secreted factors delivered by mesenchymal stromal cells. PLoS One. 2014; 9(2):e89882. PMID: 24587097.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  61. Hiddingh L, Tannous BA, Teng J, Tops B, Jeuken J, Hulleman E, Boots-Sprenger SH, Vandertop WP, Noske DP, Kaspers GJ, Wesseling P, Wurdinger T. EFEMP1 induces ?-secretase/Notch-mediated temozolomide resistance in glioblastoma. Oncotarget. 2014 Jan 30; 5(2):363-74. PMID: 24495907.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  62. Lai CP, Mardini O, Ericsson M, Prabhakar S, Maguire C, Chen JW, Tannous BA, Breakefield XO. Dynamic biodistribution of extracellular vesicles in vivo using a multimodal imaging reporter. ACS Nano. 2014 Jan 28; 8(1):483-494. PMID: 24383518.
    Citations: 68     Fields:    Translation:HumansAnimalsCells
  63. Lewandrowski GK, Magee CN, Mounayar M, Tannous BA, Azzi J. Simultaneous in vivo monitoring of regulatory and effector T lymphocytes using secreted Gaussia luciferase, Firefly luciferase, and secreted alkaline phosphatase. Methods Mol Biol. 2014; 1098:211-27. PMID: 24166380.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  64. Degeling MH, Bovenberg MS, Tannous M, Tannous BA. Gaussia luciferase-based mycoplasma detection assay in mammalian cell culture. Methods Mol Biol. 2014; 1098:47-55. PMID: 24166367.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  65. Lai CP, Tannous BA, Breakefield XO. Noninvasive in vivo monitoring of extracellular vesicles. Methods Mol Biol. 2014; 1098:249-58. PMID: 24166382.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  66. Erkan EP, Ströbel T, Lewandrowski G, Tannous B, Madlener S, Czech T, Saydam N, Saydam O. Depletion of minichromosome maintenance protein 7 inhibits glioblastoma multiforme tumor growth in vivo. Oncogene. 2014 Sep 25; 33(39):4778-85. PMID: 24166506.
    Citations: 9     Fields:    Translation:AnimalsCells
  67. Bovenberg MS, Degeling MH, Hejazi S, Amante RJ, van Keulen M, Jeuken JW, Akbaripanahi S, Vleggeert-Lankamp CL, Tannous M, Wesseling P, Wurdinger T, Tannous BA. Multiplex blood reporters for simultaneous monitoring of cellular processes. Anal Chem. 2013 Nov 05; 85(21):10205-10. PMID: 24131224.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  68. Tannous BA, Kerami M, Van der Stoop PM, Kwiatkowski N, Wang J, Zhou W, Kessler AF, Lewandrowski G, Hiddingh L, Sol N, Lagerweij T, Wedekind L, Niers JM, Barazas M, Nilsson RJ, Geerts D, De Witt Hamer PC, Hagemann C, Vandertop WP, Van Tellingen O, Noske DP, Gray NS, Würdinger T. Effects of the selective MPS1 inhibitor MPS1-IN-3 on glioblastoma sensitivity to antimitotic drugs. J Natl Cancer Inst. 2013 Sep 04; 105(17):1322-31. PMID: 23940287.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  69. Maguire CA, Crommentuijn MH, Mu D, Hudry E, Serrano-Pozo A, Hyman BT, Tannous BA. Mouse gender influences brain transduction by intravascularly administered AAV9. Mol Ther. 2013 Aug; 21(8):1470-1. PMID: 23903572.
    Citations: 11     Fields:    Translation:AnimalsCells
  70. Maguire CA, Bovenberg MS, Crommentuijn MH, Niers JM, Kerami M, Teng J, Sena-Esteves M, Badr CE, Tannous BA. Triple bioluminescence imaging for in vivo monitoring of cellular processes. Mol Ther Nucleic Acids. 2013 Jun 18; 2:e99. PMID: 23778500.
    Citations: 20     
  71. Bovenberg MS, Degeling MH, Tannous BA. Cell-based immunotherapy against gliomas: from bench to bedside. Mol Ther. 2013 Jul; 21(7):1297-305. PMID: 23648695.
    Citations: 5     Fields:    Translation:Humans
  72. Bovenberg MS, Degeling MH, Tannous BA. Advances in stem cell therapy against gliomas. Trends Mol Med. 2013 May; 19(5):281-91. PMID: 23537753.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  73. Badr CE, Van Hoppe S, Dumbuya H, Tjon-Kon-Fat LA, Tannous BA. Targeting cancer cells with the natural compound obtusaquinone. J Natl Cancer Inst. 2013 May 01; 105(9):643-53. PMID: 23479453.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  74. Degeling MH, Bovenberg MS, Lewandrowski GK, de Gooijer MC, Vleggeert-Lankamp CL, Tannous M, Maguire CA, Tannous BA. Directed molecular evolution reveals Gaussia luciferase variants with enhanced light output stability. Anal Chem. 2013 Mar 05; 85(5):3006-12. PMID: 23425213.
    Citations: 8     Fields:    Translation:Cells
  75. van Rijn S, Nilsson J, Noske DP, Vandertop WP, Tannous BA, Würdinger T. Functional multiplex reporter assay using tagged Gaussia luciferase. Sci Rep. 2013; 3:1046. PMID: 23308339.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  76. Pike LS, Tannous BA, Deliolanis NC, Hsich G, Morse D, Tung CH, Sena-Esteves M, Breakefield XO. Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis. Gene Ther. 2012 Nov; 19(11):1121. PMID: 23135206.
    Citations:    
  77. Kodack DP, Chung E, Yamashita H, Incio J, Duyverman AM, Song Y, Farrar CT, Huang Y, Ager E, Kamoun W, Goel S, Snuderl M, Lussiez A, Hiddingh L, Mahmood S, Tannous BA, Eichler AF, Fukumura D, Engelman JA, Jain RK. Combined targeting of HER2 and VEGFR2 for effective treatment of HER2-amplified breast cancer brain metastases. Proc Natl Acad Sci U S A. 2012 Nov 06; 109(45):E3119-27. PMID: 23071298.
    Citations: 39     Fields:    Translation:HumansAnimalsCells
  78. Degeling MH, Maguire CA, Bovenberg MS, Tannous BA. Sensitive assay for mycoplasma detection in mammalian cell culture. Anal Chem. 2012 May 01; 84(9):4227-32. PMID: 22506739.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  79. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bánhegyi G, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Béchet DM, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Besteiro S, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bost F, Bourquin JP, Boya P, Boyer-Guittaut M, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cahová M, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Colombo MI, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Crespo JL, Cronjé MJ, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dengjel J, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Díaz-Araya G, Díaz-Laviada I, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Dreux M, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Farré JC, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Fésüs L, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fuentes JM, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, Garcia-Manero G, Garcia-Marcos M, Garmyn M, Gartel AL, Gatti E, Gautel M, Gawriluk TR, Gegg ME, Geng J, Germain M, Gestwicki JE, Gewirtz DA, Ghavami S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490.
    Citations: 1363     Fields:    Translation:HumansAnimals
  80. Morse D, Tannous BA. A water-soluble coelenterazine for sensitive in vivo imaging of coelenterate luciferases. Mol Ther. 2012 Apr; 20(4):692-3. PMID: 22472977.
    Citations: 9     Fields:    Translation:Animals
  81. Niers JM, Chen JW, Lewandrowski G, Kerami M, Garanger E, Wojtkiewicz G, Waterman P, Keliher E, Weissleder R, Tannous BA. Single reporter for targeted multimodal in vivo imaging. J Am Chem Soc. 2012 Mar 21; 134(11):5149-56. PMID: 22397453.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  82. Maguire CA, Balaj L, Sivaraman S, Crommentuijn MH, Ericsson M, Mincheva-Nilsson L, Baranov V, Gianni D, Tannous BA, Sena-Esteves M, Breakefield XO, Skog J. Microvesicle-associated AAV vector as a novel gene delivery system. Mol Ther. 2012 May; 20(5):960-71. PMID: 22314290.
    Citations: 53     Fields:    Translation:HumansCells
  83. Maguire CA, van der Mijn JC, Degeling MH, Morse D, Tannous BA. Codon-optimized Luciola italica luciferase variants for mammalian gene expression in culture and in vivo. Mol Imaging. 2012 Feb; 11(1):13-21. PMID: 22418023.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  84. Bovenberg MS, Degeling MH, Tannous BA. Enhanced Gaussia luciferase blood assay for monitoring of in vivo biological processes. Anal Chem. 2012 Jan 17; 84(2):1189-92. PMID: 22148161.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  85. Pike LS, Tannous BA, Deliolanis NC, Hsich G, Morse D, Tung CH, Sena-Esteves M, Breakefield XO. Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis. Gene Ther. 2011 Dec; 18(12):1173-8. PMID: 21900963.
    Citations: 2     Fields:    Translation:AnimalsCells
  86. Tannous BA, Teng J. Secreted blood reporters: insights and applications. Biotechnol Adv. 2011 Nov-Dec; 29(6):997-1003. PMID: 21920429.
    Citations: 13     Fields:    Translation:HumansAnimals
  87. Badr CE, Tannous BA. Bioluminescence imaging: progress and applications. Trends Biotechnol. 2011 Dec; 29(12):624-33. PMID: 21788092.
    Citations: 52     Fields:    Translation:Humans
  88. Badr CE, Wurdinger T, Nilsson J, Niers JM, Whalen M, Degterev A, Tannous BA. Lanatoside C sensitizes glioblastoma cells to tumor necrosis factor-related apoptosis-inducing ligand and induces an alternative cell death pathway. Neuro Oncol. 2011 Nov; 13(11):1213-24. PMID: 21757445.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  89. Nery FC, Armata IA, Farley JE, Cho JA, Yaqub U, Chen P, da Hora CC, Wang Q, Tagaya M, Klein C, Tannous B, Caldwell KA, Caldwell GA, Lencer WI, Ye Y, Breakefield XO. TorsinA participates in endoplasmic reticulum-associated degradation. Nat Commun. 2011 Jul 12; 2:393. PMID: 21750546.
    Citations: 43     Fields:    Translation:HumansAnimalsCells
  90. Gabriely G, Yi M, Narayan RS, Niers JM, Wurdinger T, Imitola J, Ligon KL, Kesari S, Esau C, Stephens RM, Tannous BA, Krichevsky AM. Human glioma growth is controlled by microRNA-10b. Cancer Res. 2011 May 15; 71(10):3563-72. PMID: 21471404.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  91. Deliolanis NC, Wurdinger T, Pike L, Tannous BA, Breakefield XO, Weissleder R, Ntziachristos V. In vivo tomographic imaging of red-shifted fluorescent proteins. Biomed Opt Express. 2011 Mar 16; 2(4):887-900. PMID: 21483611.
    Citations: 8     
  92. Niers JM, Kerami M, Pike L, Lewandrowski G, Tannous BA. Multimodal in vivo imaging and blood monitoring of intrinsic and extrinsic apoptosis. Mol Ther. 2011 Jun; 19(6):1090-6. PMID: 21343914.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  93. Smits M, Mir SE, Nilsson RJ, van der Stoop PM, Niers JM, Marquez VE, Cloos J, Breakefield XO, Krichevsky AM, Noske DP, Tannous BA, Würdinger T. Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2. PLoS One. 2011 Jan 28; 6(1):e16282. PMID: 21297974.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  94. Niers JM, Chen JW, Weissleder R, Tannous BA. Enhanced in vivo imaging of metabolically biotinylated cell surface reporters. Anal Chem. 2011 Feb 01; 83(3):994-9. PMID: 21214190.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  95. Sharma R, Tsuchiya M, Tannous BA, Bartlett JD. Measurement of fluoride-induced endoplasmic reticulum stress using Gaussia luciferase. Methods Enzymol. 2011; 491:111-25. PMID: 21329797.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  96. Badr CE, Wurdinger T, Tannous BA. Functional drug screening assay reveals potential glioma therapeutics. Assay Drug Dev Technol. 2011 Jun; 9(3):281-9. PMID: 21184646.
    Citations: 14     Fields:    Translation:HumansCells
  97. Badr CE, Niers JM, Morse D, Koelen JA, Vandertop P, Noske D, Wurdinger T, Zalloua PA, Tannous BA. Suicidal gene therapy in an NF-?B-controlled tumor environment as monitored by a secreted blood reporter. Gene Ther. 2011 May; 18(5):445-51. PMID: 21150937.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  98. Smits M, Nilsson J, Mir SE, van der Stoop PM, Hulleman E, Niers JM, de Witt Hamer PC, Marquez VE, Cloos J, Krichevsky AM, Noske DP, Tannous BA, Würdinger T. miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis. Oncotarget. 2010 Dec; 1(8):710-20. PMID: 21321380.
    Citations: 91     Fields:    Translation:HumansAnimalsCells
  99. Mir SE, De Witt Hamer PC, Krawczyk PM, Balaj L, Claes A, Niers JM, Van Tilborg AA, Zwinderman AH, Geerts D, Kaspers GJ, Peter Vandertop W, Cloos J, Tannous BA, Wesseling P, Aten JA, Noske DP, Van Noorden CJ, Würdinger T. In silico analysis of kinase expression identifies WEE1 as a gatekeeper against mitotic catastrophe in glioblastoma. Cancer Cell. 2010 Sep 14; 18(3):244-57. PMID: 20832752.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  100. Sharma R, Tsuchiya M, Skobe Z, Tannous BA, Bartlett JD. The acid test of fluoride: how pH modulates toxicity. PLoS One. 2010 May 28; 5(5):e10895. PMID: 20531944.
    Citations: 14     Fields:    Translation:AnimalsCells
  101. Chung E, Yamashita H, Au P, Tannous BA, Fukumura D, Jain RK. Secreted Gaussia luciferase as a biomarker for monitoring tumor progression and treatment response of systemic metastases. PLoS One. 2009 Dec 15; 4(12):e8316. PMID: 20016816.
    Citations: 34     Fields:    Translation:AnimalsCells
  102. Prabhakar S, Brenner GJ, Sung B, Messerli SM, Mao J, Sena-Esteves M, Stemmer-Rachamimov A, Tannous B, Breakefield XO. Imaging and therapy of experimental schwannomas using HSV amplicon vector-encoding apoptotic protein under Schwann cell promoter. Cancer Gene Ther. 2010 Apr; 17(4):266-74. PMID: 19834516.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  103. Badr CE, Niers JM, Tjon-Kon-Fat LA, Noske DP, Wurdinger T, Tannous BA. Real-time monitoring of nuclear factor kappaB activity in cultured cells and in animal models. Mol Imaging. 2009 Sep-Oct; 8(5):278-90. PMID: 19796605.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  104. Saydam O, Shen Y, Würdinger T, Senol O, Boke E, James MF, Tannous BA, Stemmer-Rachamimov AO, Yi M, Stephens RM, Fraefel C, Gusella JF, Krichevsky AM, Breakefield XO. Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathway. Mol Cell Biol. 2009 Nov; 29(21):5923-40. PMID: 19703993.
    Citations: 95     Fields:    Translation:HumansCells
  105. Maguire CA, Deliolanis NC, Pike L, Niers JM, Tjon-Kon-Fat LA, Sena-Esteves M, Tannous BA. Gaussia luciferase variant for high-throughput functional screening applications. Anal Chem. 2009 Aug 15; 81(16):7102-6. PMID: 19601604.
    Citations: 26     Fields:    Translation:AnimalsCells
  106. van Vuurden DG, Yazdani M, Bosma I, Broekhuizen AJ, Postma TJ, Heimans JJ, van der Valk P, Aronica E, Tannous BA, Würdinger T, Kaspers GJ, Cloos J. Attenuated AMPA receptor expression allows glioblastoma cell survival in glutamate-rich environment. PLoS One. 2009 Jun 18; 4(6):e5953. PMID: 19536293.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  107. Deliolanis NC, Dunham J, Wurdinger T, Figueiredo JL, Tannous BA, Bakhos T, Ntziachristos V. In-vivo imaging of murine tumors using complete-angle projection fluorescence molecular tomography. J Biomed Opt. 2009 May-Jun; 14(3):030509. PMID: 19566290.
    Citations: 14     Fields:    Translation:Animals
  108. Würdinger T, Tannous BA. Glioma angiogenesis: Towards novel RNA therapeutics. Cell Adh Migr. 2009 Apr-Jun; 3(2):230-5. PMID: 19262177.
    Citations: 11     Fields:    Translation:Humans
  109. Tannous BA, Christensen AP, Pike L, Wurdinger T, Perry KF, Saydam O, Jacobs AH, García-Añoveros J, Weissleder R, Sena-Esteves M, Corey DP, Breakefield XO. Mutant sodium channel for tumor therapy. Mol Ther. 2009 May; 17(5):810-9. PMID: 19259066.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  110. Tannous BA. Gaussia luciferase reporter assay for monitoring biological processes in culture and in vivo. Nat Protoc. 2009; 4(4):582-91. PMID: 19373229.
    Citations: 90     Fields:    Translation:HumansAnimalsCells
  111. Würdinger T, Tannous BA, Saydam O, Skog J, Grau S, Soutschek J, Weissleder R, Breakefield XO, Krichevsky AM. miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells. Cancer Cell. 2008 Nov 04; 14(5):382-93. PMID: 18977327.
    Citations: 142     Fields:    Translation:HumansAnimalsCells
  112. Tannous B, Lee-Lewandrowski E, Sharples C, Brugge W, Bigatello L, Thompson T, Benzer T, Lewandrowski K. Comparison of conventional guaiac to four immunochemical methods for fecal occult blood testing: implications for clinical practice in hospital and outpatient settings. Clin Chim Acta. 2009 Feb; 400(1-2):120-2. PMID: 19000907.
    Citations: 5     Fields:    Translation:Humans
  113. Deliolanis NC, Kasmieh R, Wurdinger T, Tannous BA, Shah K, Ntziachristos V. Performance of the red-shifted fluorescent proteins in deep-tissue molecular imaging applications. J Biomed Opt. 2008 Jul-Aug; 13(4):044008. PMID: 19021336.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  114. Lewandrowski K, Flood J, Finn C, Tannous B, Farris AB, Benzer TI, Lee-Lewandrowski E. Implementation of point-of-care rapid urine testing for drugs of abuse in the emergency department of an academic medical center: impact on test utilization and ED length of stay. Am J Clin Pathol. 2008 May; 129(5):796-801. PMID: 18426741.
    Citations: 2     Fields:    Translation:Humans
  115. Hewett JW, Nery FC, Niland B, Ge P, Tan P, Hadwiger P, Tannous BA, Sah DW, Breakefield XO. siRNA knock-down of mutant torsinA restores processing through secretory pathway in DYT1 dystonia cells. Hum Mol Genet. 2008 May 15; 17(10):1436-45. PMID: 18258738.
    Citations: 34     Fields:    Translation:HumansCells
  116. Wurdinger T, Badr C, Pike L, de Kleine R, Weissleder R, Breakefield XO, Tannous BA. A secreted luciferase for ex vivo monitoring of in vivo processes. Nat Methods. 2008 Feb; 5(2):171-3. PMID: 18204457.
    Citations: 118     Fields:    Translation:HumansAnimalsCells
  117. Lee-Lewandrowski E, Januzzi JL, Green SM, Tannous B, Wu AH, Smith A, Wong A, Murakami MM, Kaczmarek J, Apple FS, Miller WL, Hartman K, Jaffe AS. Multi-center validation of the Response Biomedical Corporation RAMP NT-proBNP assay with comparison to the Roche Diagnostics GmbH Elecsys proBNP assay. Clin Chim Acta. 2007 Nov-Dec; 386(1-2):20-4. PMID: 17854790.
    Citations: 2     Fields:    Translation:Humans
  118. Badr CE, Hewett JW, Breakefield XO, Tannous BA. A highly sensitive assay for monitoring the secretory pathway and ER stress. PLoS One. 2007 Jun 27; 2(6):e571. PMID: 17593970.
    Citations: 57     Fields:    Translation:HumansAnimalsCells
  119. Hewett JW, Tannous B, Niland BP, Nery FC, Zeng J, Li Y, Breakefield XO. Mutant torsinA interferes with protein processing through the secretory pathway in DYT1 dystonia cells. Proc Natl Acad Sci U S A. 2007 Apr 24; 104(17):7271-6. PMID: 17428918.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  120. Niland B, Hewett J, Tannous BA and Breakefield XO. metabolic biotinylation of TorsinA reveals intracellular fate (in preparation). 2006.
  121. Wurdinger T, Weissleder R, Breakefield XO and Tannous BA. Gaussia luciferase for monitoring of tumor volume in vivo by blood sampling (in preparation). 2006.
  122. Badr C, Zallou P, Breakefield XO and Tannous BA. Novel ionizing-radiation inducible system for tumor gene therapy (in preparation). 2006.
  123. Christian B, Hewett J, Breakefield XO and Tannous BA. Gaussia luciferase for monitoring of secretory pathway and ER stress (in preparation). 2006.
  124. Tannous BA. Metabolic biotinylation is cell dependent and not efficient in mammalian cells (in preparation). 2006.
  125. Hewett J, Tannous BA, Niland B and Breakefield XO. Mutant torsinA interfers with protein processing through the secretory pathway in DYT1 dystonia cells (submitted to PNAS). 2006.
  126. Tannous BA, Hewett J, Breakefield XO. A versatile, highly sensitive assay for monitoring of protein secretion, promoter activity and cell viability. 2006.
  127. Tannous BA, Grimm J, Perry KF, Chen JW, Weissleder R, Breakefield XO. Metabolic biotinylation of cell surface receptors for in vivo imaging. Nat Methods. 2006 May; 3(5):391-6. PMID: 16628210.
    Citations: 40     Fields:    Translation:HumansCells
  128. Badr C, Zalloua P, Breakefield XO, Tannous BA . Imaging of radiation-inducible promoters using a naturally secreted luciferase from the marine copepod Gaussia princeps. Mol Therapy. 2006; 13(S1):S369.
  129. Tannous BA, Perry KF, Sena-Esteves M, Christensen A, Garcia-Anoveros J, Jacobs A, Corey D, Weissleder R, Breakefield XO . Tumor therapy via vector-regulated expression of mutant sodium channel. Mol Therapy. 2006; 13(S1):S370.
  130. Tannous BA, Grimm J, Perry K, Weissleder R, Breakefield XO . Metabolic biotinylation of cell surface receptors for imaging. Mol. Therapy. 2006; 13(S1):S386.
  131. Tannous BA, Badr C, Weissleder R, Breakefield XO, Zalloua P . Ionizing radiation-inducible system for imaging of gene expression. Mol Imaging. 2006; 5:384.
  132. Tannous BA, Perry K, Sena-Esteves M, Garcia-Anoveros J, Jacobs A, Corey D, Weissleder R, Breakefield XO . Mutant Sodium Channel for Tumor Therapy. Mol Imaging. 2006; 5:341.
  133. Tannous BA, Grimm J, Perry KF, Weissleder R, Breakefield XO. Metabolic biotinylation of mammalian cell receptors for imaging. Nat Protocols. 2006; 10.1038:132.
  134. Wurdinger T, Badr C, Weissleder R, Breakefield XO, Tannous BA. Novel construct for imaging of NF-êB activation using bioluminescence. Mol Imaging. 2006; 5:384.
  135. Tannous BA, Kim DE, Fernandez JL, Weissleder R, Breakefield XO. Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo. Mol Ther. 2005 Mar; 11(3):435-43. PMID: 15727940.
    Citations: 220     Fields:    Translation:HumansAnimals
  136. Emmanouilidou E, Tannous B, Ioannou PC, Christopoulos TK. Duplex RT-PCR and chemiluminometric hybridization assay for combined screening of the mRNAs of prostate-specific antigen and prostate-specific membrane antigen in peripheral blood. Anal Chim Acta. 2005; 531(2):193-198.
  137. Breakefield XO, Tannous BA, Shah K, Grimm J, Tang Y, Tung C, Weissleder R. Imaging fate and action of gene and stem cell-based therapies in the central nervous system. Mol Imaging. 2005; 4:217.
  138. Tannous BA, Verhaegen M, Christopoulos TK, Kourakli A. Combined flash- and glow-type chemiluminescent reactions for high-throughput genotyping of biallelic polymorphisms. Anal Biochem. 2003 Sep 15; 320(2):266-72. PMID: 12927833.
    Citations:    Fields:    
  139. Tannous BA, Laios E, Christopoulos TK. T7 RNA polymerase as a self-replicating label for antigen quantification. Nucleic Acids Res. 2002 Dec 15; 30(24):e140. PMID: 12490731.
    Citations:    Fields:    Translation:Cells
  140. Tannous BA, Chiu NHL, Christopoulos TK. Heterobifunctional linker between antibodies and reporter genes for immunoassay development. Analytica Chimica Acta. 2002; 459(2):169-176.
  141. Tannous BA. Novel methods for antigens and nucleic acids analysis. 2002.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.