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Caroline M Mitchell, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AI158836 (MITCHELL, CAROLINE M) Sep 20, 2021 - Aug 31, 2026
    NIH
    Vaginal microbiota transplant to promote Lactobacillus-dominant cervicovaginal communities
    Role: Principal Investigator
  2. R21AI156038 (MITCHELL, CAROLINE M) Mar 19, 2021 - Feb 28, 2023
    NIH
    Effect of B-cell depletion on vaginal microbiota and mucosal immunity
    Role: Principal Investigator
  3. R21AI113439 (MITCHELL, CAROLINE M) Jul 15, 2015 - Jun 30, 2018
    NIH
    Novel mechanisms of pathogenesis in idiopathic vaginitis
    Role: Principal Investigator
  4. K08AI087969 (MITCHELL, CAROLINE M) Apr 1, 2010 - May 31, 2015
    NIH
    Female Genital Innate Immune Response to Vaginal Microbiota
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Mitchell CM, Anyalechi GE, Cohen CR, Haggerty CL, Manhart LE, Hillier SL. Etiology and Diagnosis of Pelvic Inflammatory Disease: Looking Beyond Gonorrhea and Chlamydia. J Infect Dis. 2021 Aug 16; 224(Supplement_2):S29-S35. PMID: 34396407.
    Citations:    Fields:    
  2. Yockey L, Dowst S, Zonozi R, Huizenga N, Murphy P, Laliberte K, Rosenthal J, Niles JL, Mitchell CM. Inflammatory vaginitis in women on long-term rituximab treatment for autoimmune disorders. BMC Womens Health. 2021 08 05; 21(1):285. PMID: 34353326.
    Citations:    Fields:    Translation:Humans
  3. Vagios S, Mitchell CM. Mutual Preservation: A Review of Interactions Between Cervicovaginal Mucus and Microbiota. Front Cell Infect Microbiol. 2021; 11:676114. PMID: 34327149.
    Citations:    Fields:    Translation:HumansCells
  4. Mitchell CM, Srinivasan S, Ma N, Reed SD, Wu MC, Hoffman NG, Valint DJ, Proll S, Fiedler TL, Agnew KJ, Guthrie KA, Fredricks DN. Bacterial Communities Associated With Abnormal Nugent Score in Postmenopausal Versus Premenopausal Women. J Infect Dis. 2021 Jun 15; 223(12):2048-2052. PMID: 33107562.
    Citations:    Fields:    
  5. Lensen S, Bell RJ, Carpenter JS, Christmas M, Davis SR, Giblin K, Goldstein SR, Hillard T, Hunter MS, Iliodromiti S, Jaisamrarn U, Khandelwal S, Kiesel L, Kim BV, Lumsden MA, Maki PM, Mitchell CM, Nappi RE, Niederberger C, Panay N, Roberts H, Shifren J, Simon JA, Stute P, Vincent A, Wolfman W, Hickey M. A core outcome set for genitourinary symptoms associated with menopause: the COMMA (Core Outcomes in Menopause) global initiative. Menopause. 2021 05 10; 28(8):859-866. PMID: 33973541.
    Citations: 1     Fields:    Translation:Humans
  6. Mitchell CM, Ma N, Mitchell AJ, Wu MC, Valint DJ, Proll S, Reed SD, Guthrie KA, Lacroix AZ, Larson JC, Pepin R, Raftery D, Fredricks DN, Srinivasan S. Association between postmenopausal vulvovaginal discomfort, vaginal microbiota, and mucosal inflammation. Am J Obstet Gynecol. 2021 08; 225(2):159.e1-159.e15. PMID: 33675793.
    Citations:    Fields:    Translation:HumansCells
  7. Hudson PL, Ling W, Wu MC, Hayward MR, Mitchell AJ, Larson J, Guthrie KA, Reed SD, Kwon DS, Mitchell CM. Comparison of the vaginal microbiota in postmenopausal Black and White women. J Infect Dis. 2020 Dec 23. PMID: 33367735.
    Citations:    Fields:    
  8. Mitchell CM, Mazzoni C, Hogstrom L, Bryant A, Bergerat A, Cher A, Pochan S, Herman P, Carrigan M, Sharp K, Huttenhower C, Lander ES, Vlamakis H, Xavier RJ, Yassour M. Delivery Mode Affects Stability of Early Infant Gut Microbiota. Cell Rep Med. 2020 Dec 22; 1(9):100156. PMID: 33377127.
    Citations: 5     
  9. Mitchell CM. How do we measure success in the treatment of genitourinary syndrome of menopause? Menopause. 2020 08; 27(8):844-845. PMID: 32744829.
    Citations: 1     Fields:    Translation:Humans
  10. Mitchell CM, Reed SD, Diem S, Ensrud KE, LaCroix AZ, Newton KM, Guthrie KA. To the Editor. Menopause. 2020 07; 27(7):836-837. PMID: 32604325.
    Citations:    Fields:    
  11. Reed SD, LaCroix AZ, Anderson GL, Ensrud KE, Caan B, Carpenter JS, Cohen L, Diem SJ, Freeman EW, Joffe H, Larson JC, McCurry SM, Mitchell CM, Newton KM, Sternfeld B, Guthrie KA. Lights on MsFLASH: a review of contributions. Menopause. 2020 04; 27(4):473-484. PMID: 31977667.
    Citations: 1     Fields:    Translation:Humans
  12. Mitchell CM, Watson L, Mitchell AJ, Hyrien O, Bergerat A, Valint DJ, Pascale A, Hoffman N, Srinivasan S, Fredricks DN. Vaginal Microbiota and Mucosal Immune Markers in Women With Vulvovaginal Discomfort. Sex Transm Dis. 2020 04; 47(4):269-274. PMID: 32044865.
    Citations: 2     Fields:    Translation:HumansCells
  13. Hunter MM, Guthrie KA, Larson JC, Reed SD, Mitchell CM, Diem SJ, LaCroix AZ, Huang AJ. Convergent-Divergent Validity and Correlates of the Day-to-Day Impact of Vaginal Aging Domain Scales in the MsFLASH Vaginal Health Trial. J Sex Med. 2020 01; 17(1):117-125. PMID: 31812686.
    Citations:    Fields:    Translation:Humans
  14. O'Brien KF, Bradley SE, Mitchell CM, Cardis MA, Mauskar MM, Pasieka HB. Vulvovaginal manifestations in Stevens-Johnson syndrome and toxic epidermal necrolysis: Prevention and treatment. J Am Acad Dermatol. 2021 Aug; 85(2):523-528. PMID: 31437544.
    Citations:    Fields:    Translation:Humans
  15. Mitchell CM, Guthrie KA, Larson J, Diem S, LaCroix AZ, Caan B, Shifren JL, Woods NF, Heiman JR, Lindau ST, Reed SD. Sexual frequency and pain in a randomized clinical trial of vaginal estradiol tablets, moisturizer, and placebo in postmenopausal women. Menopause. 2019 08; 26(8):816-822. PMID: 30994576.
    Citations:    Fields:    Translation:Humans
  16. Ona S, James K, Ananthakrishnan AN, Long MD, Martin C, Chen W, Mitchell CM. Association Between Vulvovaginal Discomfort and Activity of Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol. 2020 03; 18(3):604-611.e1. PMID: 31108226.
    Citations: 1     Fields:    Translation:Humans
  17. Watson LJ, James KE, Hatoum Moeller IJ, Mitchell CM. Vulvovaginal Discomfort Is Common in Both Premenopausal and Postmenopausal Women. J Low Genit Tract Dis. 2019 Apr; 23(2):164-169. PMID: 30741753.
    Citations:    Fields:    Translation:Humans
  18. Mitchell CM, Waetjen LE. Genitourinary Changes with Aging. Obstet Gynecol Clin North Am. 2018 Dec; 45(4):737-750. PMID: 30401554.
    Citations: 6     Fields:    Translation:Humans
  19. Diem SJ, Guthrie KA, Mitchell CM, Reed SD, Larson JC, Ensrud KE, LaCroix AZ. Effects of vaginal estradiol tablets and moisturizer on menopause-specific quality of life and mood in healthy postmenopausal women with vaginal symptoms: a randomized clinical trial. Menopause. 2018 10; 25(10):1086-1093. PMID: 29738424.
    Citations: 4     Fields:    Translation:Humans
  20. Mitchell CM, Reed SD, Guthrie KA. Time to advocate for better science, and better treatments for women. Menopause. 2018 10; 25(10):1065-1068. PMID: 30085982.
    Citations: 1     Fields:    Translation:Humans
  21. Mitchell CM, Reed SD, Guthrie KA. Good Clinical Practice in Diagnosis of Vulvovaginal Symptoms-Reply. JAMA Intern Med. 2018 08 01; 178(8):1136-1137. PMID: 30083740.
    Citations:    Fields:    Translation:Humans
  22. Zhao N, Zhan X, Guthrie KA, Mitchell CM, Larson J. Generalized Hotelling's test for paired compositional data with application to human microbiome studies. Genet Epidemiol. 2018 07; 42(5):459-469. PMID: 29737047.
    Citations: 6     Fields:    Translation:Humans
  23. Mitchell CM, Srinivasan S, Plantinga A, Wu MC, Reed SD, Guthrie KA, LaCroix AZ, Fiedler T, Munch M, Liu C, Hoffman NG, Blair IA, Newton K, Freeman EW, Joffe H, Cohen L, Fredricks DN. Associations between improvement in genitourinary symptoms of menopause and changes in the vaginal ecosystem. Menopause. 2018 05; 25(5):500-507. PMID: 29206774.
    Citations: 7     Fields:    Translation:HumansCells
  24. Mitchell CM, Reed SD, Diem S, Larson JC, Newton KM, Ensrud KE, LaCroix AZ, Caan B, Guthrie KA. Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial. JAMA Intern Med. 2018 05 01; 178(5):681-690. PMID: 29554173.
    Citations: 16     Fields:    Translation:Humans
  25. Anahtar MN, Gootenberg DB, Mitchell CM, Kwon DS. Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity. . 2018 02 14; 23(2):159-168. PMID: 29447695.
    Citations: 34     Translation:HumansCells
  26. Mitchell CM. Seeing the light: the need for randomized trials of vaginal laser in postmenopausal women. Menopause. 2018 01; 25(1):7-8. PMID: 29112601.
    Citations:    Fields:    Translation:Humans
  27. Mitchell CM, Srinivasan S, Zhan X, Wu MC, Reed SD, Guthrie KA, LaCroix AZ, Fiedler T, Munch M, Liu C, Hoffman NG, Blair IA, Newton K, Freeman EW, Joffe H, Cohen L, Fredricks DN. Vaginal microbiota and genitourinary menopausal symptoms: a cross-sectional analysis. Menopause. 2017 Oct; 24(10):1160-1166. PMID: 28640154.
    Citations: 14     Fields:    Translation:HumansCells
  28. Murphy K, Mitchell CM. The Interplay of Host Immunity, Environment and the Risk of Bacterial Vaginosis and Associated Reproductive Health Outcomes. J Infect Dis. 2016 Aug 15; 214 Suppl 1:S29-35. PMID: 27056955.
    Citations: 19     Fields:    Translation:HumansCells
  29. Gordon D, Gardella C, Eschenbach D, Mitchell CM. High Prevalence of Sexual Dysfunction in a Vulvovaginal Specialty Clinic. J Low Genit Tract Dis. 2016 Jan; 20(1):80-4. PMID: 25259664.
    Citations: 1     Fields:    Translation:Humans
  30. Mitchell CM, Haick A, Nkwopara E, Garcia R, Rendi M, Agnew K, Fredricks DN, Eschenbach D. Colonization of the upper genital tract by vaginal bacterial species in nonpregnant women. Am J Obstet Gynecol. 2015 May; 212(5):611.e1-9. PMID: 25524398.
    Citations: 53     Fields:    Translation:HumansCells
  31. Mitchell CM. Positive endometrial cultures: pathologic or incidental? Menopause. 2014 Aug; 21(8):785. PMID: 24937031.
    Citations:    Fields:    Translation:Humans
  32. Reed SD, Mitchell CM, Joffe H, Cohen L, Shifren JL, Newton KM, Freeman EW, Larson JC, Manson JE, LaCroix AZ, Guthrie KA. Sexual function in women on estradiol or venlafaxine for hot flushes: a randomized controlled trial. Obstet Gynecol. 2014 Aug; 124(2 Pt 1):233-241. PMID: 25004335.
    Citations: 5     Fields:    Translation:Humans
  33. Mitchell CM, Reed SD. Vagina dialogues. Menopause. 2014 May; 21(5):437-8. PMID: 24594865.
    Citations:    Fields:    Translation:Humans
  34. Zomorodian LM, Massawe E, Makundi JP, Mitchell CM, Eschenbach DA. Obstetric care preferences and desire for maternity waiting homes among labor and delivery patients in arusha, Tanzania. Obstet Gynecol. 2014 May; 123 Suppl 1:179S-80S. PMID: 24770098.
    Citations:    
  35. Mitchell CM, McLemore L, Westerberg K, Astronomo R, Smythe K, Gardella C, Mack M, Magaret A, Patton D, Agnew K, McElrath MJ, Hladik F, Eschenbach D. Long-term effect of depot medroxyprogesterone acetate on vaginal microbiota, epithelial thickness and HIV target cells. J Infect Dis. 2014 Aug 15; 210(4):651-5. PMID: 24652495.
    Citations: 40     Fields:    Translation:HumansCells
  36. Van Etten ML, Houliston GJ, Mitchell CM, Heenan PB, Robertson AW, Tate JA. Sophora microphylla (Fabaceae) microsatellite markers and their utility across the genus. Appl Plant Sci. 2014 Mar; 2(3). PMID: 25202609.
    Citations: 3     
  37. Mitchell CM, Fredricks DN, Winer RL, Koutsky L. Effect of sexual debut on vaginal microbiota in a cohort of young women. Obstet Gynecol. 2012 Dec; 120(6):1306-13. PMID: 23168754.
    Citations: 10     Fields:    Translation:HumansCells
  38. Moreni SL, Mitchell CM, Garcia RL, Eckert LO. Loop Electrosurgical Excisional Procedure (LEEP) Done for Discrepancy: Does the Time from HGSIL Affect Pathologic Grade of CIN in LEEP Specimen? Obstet Gynecol Int. 2010; 2010:743097. PMID: 20671925.
    Citations:    
  39. Debiec KE, Paul KJ, Mitchell CM, Hitti JE. Inadequate prenatal care and risk of preterm delivery among adolescents: a retrospective study over 10 years. Am J Obstet Gynecol. 2010 Aug; 203(2):122.e1-6. PMID: 20471628.
    Citations: 31     Fields:    Translation:Humans
  40. Srinivasan S, Liu C, Mitchell CM, Fiedler TL, Thomas KK, Agnew KJ, Marrazzo JM, Fredricks DN. Temporal variability of human vaginal bacteria and relationship with bacterial vaginosis. PLoS One. 2010 Apr 15; 5(4):e10197. PMID: 20419168.
    Citations: 170     Fields:    Translation:HumansCells
  41. Mitchell CM, Hitti JE, Agnew KJ, Fredricks DN. Comparison of oral and vaginal metronidazole for treatment of bacterial vaginosis in pregnancy: impact on fastidious bacteria. BMC Infect Dis. 2009 Jun 10; 9:89. PMID: 19515236.
    Citations: 16     Fields:    Translation:HumansCells
  42. Fredricks DN, Fiedler TL, Thomas KK, Mitchell CM, Marrazzo JM. Changes in vaginal bacterial concentrations with intravaginal metronidazole therapy for bacterial vaginosis as assessed by quantitative PCR. J Clin Microbiol. 2009 Mar; 47(3):721-6. PMID: 19144794.
    Citations: 81     Fields:    Translation:HumansCells
  43. Mitchell CM, Balkus J, Agnew KJ, Cohn S, Luque A, Lawler R, Coombs RW, Hitti JE. Bacterial vaginosis, not HIV, is primarily responsible for increased vaginal concentrations of proinflammatory cytokines. AIDS Res Hum Retroviruses. 2008 May; 24(5):667-71. PMID: 18462081.
    Citations: 31     Fields:    Translation:HumansCells
  44. Reed SD, Laya MB, Melville J, Ismail SY, Mitchell CM, Ackerman DR. Prevalence of vitamin D insufficiency and clinical associations among veiled East African women in Washington State. J Womens Health (Larchmt). 2007 Mar; 16(2):206-13. PMID: 17388737.
    Citations: 6     Fields:    Translation:Humans
  45. Paul ME, Mitchell CM, Rogers AJ, Fox MC, Lackie EG. Early surgical abortion: efficacy and safety. Am J Obstet Gynecol. 2002 Aug; 187(2):407-11. PMID: 12193934.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.