Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Yin-Ching Iris Chen, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21NS108223 (CHEN, YIN-CHING IRIS) Jan 15, 2020 - Dec 31, 2021
    Altered dopaminergic function after repetitive closed head injury in adolescent mice
    Role: Principal Investigator
  2. R21AT004455 (CHEN, YIN-CHING IRIS) Mar 1, 2009 - Feb 28, 2012
    Restoring Dopamine Homeostasis by Acupuncture: A Neurocircuit Model
    Role: Principal Investigator
  3. P01AT002048 (ROSEN, BRUCE R) Sep 26, 2003 - May 31, 2011
    Neuroimaging Acupuncture Effects on Human Brain Activity
    Role: Co-Principal Investigator
  4. Z01DK029028 (CHEN, YIN-CHING IRIS)
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ren J, Chen YI, Mackey AM, Liu PK. Imaging rhodopsin degeneration in vivo in a new model of ocular ischemia in living mice. FASEB J. 2016 Feb; 30(2):612-23. PMID: 26443823; PMCID: PMC4714550.
    Citations: 1     Fields:    Translation:AnimalsCells
  2. Choi JK, Mandeville JB, Chen YI, Kim YR, Jenkins BG. High resolution spatial mapping of nicotine action using pharmacologic magnetic resonance imaging. Synapse. 2006 Aug; 60(2):152-7. PMID: 16715493.
    Citations: 11     Fields:    Translation:Animals
  3. Choi JK, Chen YI, Hamel E, Jenkins BG. Brain hemodynamic changes mediated by dopamine receptors: Role of the cerebral microvasculature in dopamine-mediated neurovascular coupling. Neuroimage. 2006 Apr 15; 30(3):700-12. PMID: 16459104.
    Citations: 96     Fields:    Translation:Animals
  4. Chen YC, Choi JK, Andersen SL, Rosen BR, Jenkins BG. Mapping dopamine D2/D3 receptor function using pharmacological magnetic resonance imaging. Psychopharmacology (Berl). 2005 Aug; 180(4):705-15. PMID: 15536545.
    Citations: 43     Fields:    Translation:Animals
  5. Chen YI, Choi JK, Jenkins BG. Mapping interactions between dopamine and adenosine A2a receptors using pharmacologic MRI. Synapse. 2005 Feb; 55(2):80-8. PMID: 15529335.
    Citations: 5     Fields:    Translation:Animals
  6. Mandeville JB, Jenkins BG, Chen YC, Choi JK, Kim YR, Belen D, Liu C, Kosofsky BE, Marota JJ. Exogenous contrast agent improves sensitivity of gradient-echo functional magnetic resonance imaging at 9.4 T. Magn Reson Med. 2004 Dec; 52(6):1272-81. PMID: 15562489.
    Citations: 41     Fields:    Translation:Animals
  7. Jenkins BG, Sanchez-Pernaute R, Brownell AL, Chen YC, Isacson O. Mapping dopamine function in primates using pharmacologic magnetic resonance imaging. J Neurosci. 2004 Oct 27; 24(43):9553-60. PMID: 15509742; PMCID: PMC2629666.
    Citations: 41     Fields:    Translation:Animals
  8. Brownell AL, Chen YI, Yu M, Wang X, Dedeoglu A, Cicchetti F, Jenkins BG, Beal MF. 3-Nitropropionic acid-induced neurotoxicity--assessed by ultra high resolution positron emission tomography with comparison to magnetic resonance spectroscopy. J Neurochem. 2004 Jun; 89(5):1206-14. PMID: 15147513.
    Citations: 7     Fields:    Translation:Animals
  9. Brownell AL, Canales K, Chen YI, Jenkins BG, Owen C, Livni E, Yu M, Cicchetti F, Sanchez-Pernaute R, Isacson O. Mapping of brain function after MPTP-induced neurotoxicity in a primate Parkinson's disease model. Neuroimage. 2003 Oct; 20(2):1064-75. PMID: 14568476.
    Citations: 22     Fields:    Translation:Animals
  10. Yu M, Någren K, Chen YI, Livni E, Elmaleh D, Kozikowski A, Wang X, Jokivarsi K, Brownell AL. Radiolabeling and biodistribution of methyl 2-(methoxycarbonyl)-2-(methylamino) bicyclo[2.1.1] -hexane -5-carboxylate, a potential neuroprotective drug. Life Sci. 2003 Aug 08; 73(12):1577-85. PMID: 12865097.
    Citations: 2     Fields:    Translation:Animals
  11. Rosas HD, Koroshetz WJ, Chen YI, Skeuse C, Vangel M, Cudkowicz ME, Caplan K, Marek K, Seidman LJ, Makris N, Jenkins BG, Goldstein JM. Evidence for more widespread cerebral pathology in early HD: an MRI-based morphometric analysis. Neurology. 2003 May 27; 60(10):1615-20. PMID: 12771251.
    Citations: 159     Fields:    Translation:Humans
  12. Cicchetti F, Brownell AL, Williams K, Chen YI, Livni E, Isacson O. Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci. 2002 Mar; 15(6):991-8. PMID: 11918659.
    Citations: 128     Fields:    Translation:AnimalsCells
  13. Bjorklund LM, Sánchez-Pernaute R, Chung S, Andersson T, Chen IY, McNaught KS, Brownell AL, Jenkins BG, Wahlestedt C, Kim KS, Isacson O. Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model. Proc Natl Acad Sci U S A. 2002 Feb 19; 99(4):2344-9. PMID: 11782534; PMCID: PMC122367.
    Citations: 282     Fields:    Translation:AnimalsCells
  14. Chen YC, Mandeville JB, Nguyen TV, Talele A, Cavagna F, Jenkins BG. Improved mapping of pharmacologically induced neuronal activation using the IRON technique with superparamagnetic blood pool agents. J Magn Reson Imaging. 2001 Nov; 14(5):517-24. PMID: 11747003.
    Citations: 33     Fields:    Translation:Animals
  15. Rosas HD, Goodman J, Chen YI, Jenkins BG, Kennedy DN, Makris N, Patti M, Seidman LJ, Beal MF, Koroshetz WJ. Striatal volume loss in HD as measured by MRI and the influence of CAG repeat. Neurology. 2001 Sep 25; 57(6):1025-8. PMID: 11571328.
    Citations: 57     Fields:    Translation:HumansCells
  16. Scholz VH, Flaherty AW, Kraft E, Keltner JR, Kwong KK, Chen YI, Rosen BR, Jenkins BG. Laterality, somatotopy and reproducibility of the basal ganglia and motor cortex during motor tasks. Brain Res. 2000 Oct 06; 879(1-2):204-15. PMID: 11011024.
    Citations: 28     Fields:    Translation:Humans
  17. Nguyen TV, Brownell AL, Iris Chen YC, Livni E, Coyle JT, Rosen BR, Cavagna F, Jenkins BG. Detection of the effects of dopamine receptor supersensitivity using pharmacological MRI and correlations with PET. Synapse. 2000 Apr; 36(1):57-65. PMID: 10700026.
    Citations: 24     Fields:    Translation:Animals
  18. Chen YI, Brownell AL, Galpern W, Isacson O, Bogdanov M, Beal MF, Livni E, Rosen BR, Jenkins BG. Detection of dopaminergic cell loss and neural transplantation using pharmacological MRI, PET and behavioral assessment. Neuroreport. 1999 Sep 29; 10(14):2881-6. PMID: 10549790.
    Citations: 23     Fields:    Translation:AnimalsCells
  19. Wu MT, Hsieh JC, Xiong J, Yang CF, Pan HB, Chen YC, Tsai G, Rosen BR, Kwong KK. Central nervous pathway for acupuncture stimulation: localization of processing with functional MR imaging of the brain--preliminary experience. Radiology. 1999 Jul; 212(1):133-41. PMID: 10405732.
    Citations: 98     Fields:    Translation:HumansCTClinical Trials
  20. Rosas HD, Koroshetz WJ, Jenkins BG, Chen YI, Hayden DL, Beal MF, Cudkowicz ME. Riluzole therapy in Huntington's disease (HD). Mov Disord. 1999 Mar; 14(2):326-30. PMID: 10091628.
    Citations: 17     Fields:    Translation:HumansCTClinical Trials
  21. Jenkins BG, Chen YI, Kuestermann E, Makris NM, Nguyen TV, Kraft E, Brownell AL, Rosas HD, Kennedy DN, Rosen BR, Koroshetz WJ, Beal MF. An integrated strategy for evaluation of metabolic and oxidative defects in neurodegenerative illness using magnetic resonance techniques. Ann N Y Acad Sci. 1999; 893:214-42. PMID: 10672240.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  22. Jenkins BG, Rosas HD, Chen YC, Makabe T, Myers R, MacDonald M, Rosen BR, Beal MF, Koroshetz WJ. 1H NMR spectroscopy studies of Huntington's disease: correlations with CAG repeat numbers. Neurology. 1998 May; 50(5):1357-65. PMID: 9595987.
    Citations: 55     Fields:    Translation:HumansCells
  23. Keltner JR, Wald LL, Ledden PJ, Chen YC, Matthews RT, Küestermann EH, Baker JR, Rosen BR, Jenkins BG. A localized double-quantum filter for the in vivo detection of brain glucose. Magn Reson Med. 1998 Apr; 39(4):651-6. PMID: 9543429.
    Citations: 4     Fields:    Translation:AnimalsCells
  24. Chen YC, Galpern WR, Brownell AL, Matthews RT, Bogdanov M, Isacson O, Keltner JR, Beal MF, Rosen BR, Jenkins BG. Detection of dopaminergic neurotransmitter activity using pharmacologic MRI: correlation with PET, microdialysis, and behavioral data. Magn Reson Med. 1997 Sep; 38(3):389-98. PMID: 9339439.
    Citations: 73     Fields:    Translation:Animals
  25. Matthews RT, Ferrante RJ, Jenkins BG, Browne SE, Goetz K, Berger S, Chen IY, Beal MF. Iodoacetate produces striatal excitotoxic lesions. J Neurochem. 1997 Jul; 69(1):285-9. PMID: 9202321.
    Citations: 7     Fields:    Translation:Animals
  26. Schulz JB, Panahian N, Chen YI, Beal MF, Moskowitz MA, Rosen BR, Jenkins BG. Facilitation of postischemic reperfusion with alpha-PBN: assessment using NMR and Doppler flow techniques. Am J Physiol. 1997 Apr; 272(4 Pt 2):H1986-95. PMID: 9139987.
    Citations: 7     Fields:    Translation:Animals
  27. Jenkins BG, Brouillet E, Chen YC, Storey E, Schulz JB, Kirschner P, Beal MF, Rosen BR. Non-invasive neurochemical analysis of focal excitotoxic lesions in models of neurodegenerative illness using spectroscopic imaging. J Cereb Blood Flow Metab. 1996 May; 16(3):450-61. PMID: 8621749.
    Citations: 13     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.