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Douglas Kwon, M.D.,Ph.D.

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Biography
2009
Young Investigator Award
2011
Career Award for Medical Scientists
2011
Maxwell Finland Research Award
2012
Faculty of 1000
2014
Young Mentor Award
2015
MIT Sloan GE Ventures Finalist
2016
HBS New Ventures Award
2016
Medicine Innovation Award
2017
Swartz Transformative Scholar Award
2017
NIAID Top Women’s Health Science
2017
Wellman Foundation Award
2017
MedTech Innovator National Winner
2018
Nominee Trailblazer Prize for Clinician-Scientists

Overview
Our research focuses on the investigation of immune responses against HIV at mucosal surfaces. The vast majority of HIV is transmitted following exposure to virus at a mucosal site. Mucosal tissues, particularly gut associated lymphoid tissue (GALT), also represents the main compartment of viral replication and the largest reservoir of latently infected cells. Despite this, HIV pathogenesis has primarily been studied in the most accessible compartment- the peripheral blood. However, only 2-3% of all lymphocytes reside in the blood- a small minority relative to the 70-90% of the body’s T and B cells that reside within mucosal tissues. One of the bottlenecks to obtaining a deeper understanding of immune responses against HIV at mucosal sites is the inherently small amount of material that can be obtained from mucosal sampling. We are therefore utilizing new cutting-edge technologies to simultaneously capture multiple measures of HIV-specific immune responses using small numbers of cells. Using these methodologies we have begun to map mucosal immune responses in the GALT and female reproductive tract at a level of resolution that has not been previously possible with existing technologies. We have also characterized how the microbiome at these mucosal surfaces impacts HIV acquisition and disease progression.
See more details at: kwonlab.org

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK120485 (KWON, DOUGLAS) Sep 14, 2018 - Aug 31, 2023
    NIH/NIDDK
    Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
    Role: Principal Investigator
  2. R01HL138646 (KWON, DOUGLAS) Sep 1, 2017 - May 31, 2021
    NIH/NHLBI
    The enteric microbiome in HIV-associated chronic immune activation and cardiovascular disease
    Role: Principal Investigator
  3. (KWON, DOUGLAS) Sep 1, 2016 - Aug 31, 2018
    Bill and Melinda Gates Foundation
    Role: Project Principal Investigator
  4. R01DA042685 (LIN, NINA) Aug 15, 2016 - Jun 30, 2021
    NIH/NIDA
    Impact of smoking and its cessation on systemic and airway immune activation
    Role: Consortium Principal Investigator
  5. (WALKER, BRUCE) Aug 1, 2016 - Jul 31, 2019
    NIH
    Harvard University Center for AIDS Research
    Role: Co-director, Developmental Core

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Corleis B, Bucsan AN, Deruaz M, Vrbanac VD, Lisanti-Park AC, Gates SJ, Linder AH, Paer JM, Olson GS, Bowman BA, Schiff AE, Medoff BD, Tager AM, Luster AD, Khader SA, Kaushal D, Kwon DS. HIV-1 and SIV Infection Are Associated with Early Loss of Lung Interstitial CD4+ T Cells and Dissemination of Pulmonary Tuberculosis. Cell Rep. 2019 Feb 05; 26(6):1409-1418.e5. PMID: 30726727.
    Citations:    
  2. Metsky HC, Siddle KJ, Gladden-Young A, Qu J, Yang DK, Brehio P, Goldfarb A, Piantadosi A, Wohl S, Carter A, Lin AE, Barnes KG, Tully DC, Corleis B, Hennigan S, Barbosa-Lima G, Vieira YR, Paul LM, Tan AL, Garcia KF, Parham LA, Odia I, Eromon P, Folarin OA, Goba A, Simon-Lorière E, Hensley L, Balmaseda A, Harris E, Kwon DS, Allen TM, Runstadler JA, Smole S, Bozza FA, Souza TML, Isern S, Michael SF, Lorenzana I, Gehrke L, Bosch I, Ebel G, Grant DS, Happi CT, Park DJ, Gnirke A, Sabeti PC, Matranga CB. Capturing sequence diversity in metagenomes with comprehensive and scalable probe design. Nat Biotechnol. 2019 02; 37(2):160-168. PMID: 30718881.
    Citations:    
  3. Piantadosi A, Freije CA, Gosmann C, Ye S, Park D, Schaffner SF, Tully DC, Allen TM, Dong KL, Sabeti PC, Kwon DS. Metagenomic Sequencing of HIV-1 in the Blood and Female Genital Tract Reveals Little Quasispecies Diversity during Acute Infection. J Virol. 2019 Jan 15; 93(2). PMID: 30381486.
    Citations:    Fields:    
  4. Olson GS, Moore SW, Richter JM, Garber JJ, Bowman BA, Rawlings CA, Flagg M, Corleis B, Kwon DS. Increased frequency of systemic pro-inflammatory Vd1+ ?d T cells in HIV elite controllers correlates with gut viral load. Sci Rep. 2018 Nov 07; 8(1):16471. PMID: 30405182.
    Citations:    Fields:    
  5. Ndung'u T, Dong KL, Kwon DS, Walker BD. A FRESH approach: Combining basic science and social good. Sci Immunol. 2018 Sep 14; 3(27). PMID: 30217812.
    Citations:    Fields:    
  6. North CM, Muyanja D, Kakuhikire B, Tsai AC, Tracy RP, Hunt PW, Kwon DS, Christiani DC, Okello S, Siedner MJ. Brief Report: Systemic Inflammation, Immune Activation, and Impaired Lung Function Among People Living With HIV in Rural Uganda. J Acquir Immune Defic Syndr. 2018 Aug 15; 78(5):543-548. PMID: 29683991.
    Citations:    Fields:    
  7. Siedner MJ, Zanni M, Tracy RP, Kwon DS, Tsai AC, Kakuhire B, Hunt PW, Okello S. Increased Systemic Inflammation and Gut Permeability Among Women With Treated HIV Infection in Rural Uganda. J Infect Dis. 2018 Aug 14; 218(6):922-926. PMID: 29718342.
    Citations:    Fields:    
  8. Lu LL, Kwon DS, Barczak AK. Introduction: Physician-Scientists in the Evolving Landscape of Biomedical Research. J Infect Dis. 2018 Aug 14; 218(suppl_1):S1-S2. PMID: 30124978.
    Citations:    Fields:    
  9. Anahtar MN, Gootenberg DB, Mitchell CM, Kwon DS. Cervicovaginal Microbiota and Reproductive Health: The Virtue of Simplicity. Cell Host Microbe. 2018 02 14; 23(2):159-168. PMID: 29447695.
    Citations: 1     Fields:    Translation:HumansCells
  10. Farcasanu M, Kwon DS. The Influence of Cervicovaginal Microbiota on Mucosal Immunity and Prophylaxis in the Battle against HIV. Curr HIV/AIDS Rep. 2018 02; 15(1):30-38. PMID: 29516267.
    Citations:    Fields:    
  11. Dong KL, Moodley A, Kwon DS, Ghebremichael MS, Dong M, Ismail N, Ndhlovu ZM, Mabuka JM, Muema DM, Pretorius K, Lin N, Walker BD, Ndung'u T. Detection and treatment of Fiebig stage I HIV-1 infection in young at-risk women in South Africa: a prospective cohort study. Lancet HIV. 2018 01; 5(1):e35-e44. PMID: 28978417.
    Citations:    Fields:    Translation:HumansCells
  12. Shen S, Lim G, You Z, Ding W, Huang P, Ran C, Doheny J, Caravan P, Tate S, Hu K, Kim H, McCabe M, Huang B, Xie Z, Kwon D, Chen L, Mao J. Gut microbiota is critical for the induction of chemotherapy-induced pain. Nat Neurosci. 2017 Sep; 20(9):1213-1216. PMID: 28714953.
    Citations: 4     Fields:    Translation:AnimalsCells
  13. Körner C, Simoneau CR, Schommers P, Granoff M, Ziegler M, Hölzemer A, Lunemann S, Chukwukelu J, Corleis B, Naranbhai V, Kwon DS, Scully EP, Jost S, Kirchhoff F, Carrington M, Altfeld M. HIV-1-Mediated Downmodulation of HLA-C Impacts Target Cell Recognition and Antiviral Activity of NK Cells. Cell Host Microbe. 2017 Jul 12; 22(1):111-119.e4. PMID: 28704647.
    Citations: 3     Fields:    Translation:HumansCells
  14. Dugast AS, Arnold K, Lofano G, Moore S, Hoffner M, Simek M, Poignard P, Seaman M, Suscovich TJ, Pereyra F, Walker BD, Lauffenburger D, Kwon DS, Keele BF, Alter G. Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV. Clin Infect Dis. 2017 04 15; 64(8):1098-1104. PMID: 28158448.
    Citations: 8     Fields:    Translation:HumansCells
  15. Corleis B, Lisanti AC, Körner C, Schiff AE, Rosenberg ES, Allen TM, Altfeld M, Kwon DS. Early type I Interferon response induces upregulation of human ß-defensin 1 during acute HIV-1 infection. PLoS One. 2017; 12(3):e0173161. PMID: 28253319.
    Citations: 2     Fields:    Translation:HumansCells
  16. Drew DA, Chin SM, Gilpin KK, Parziale M, Pond E, Schuck MM, Stewart K, Flagg M, Rawlings CA, Backman V, Carolan PJ, Chung DC, Colizzo FP, Freedman M, Gala M, Garber JJ, Huttenhower C, Kedrin D, Khalili H, Kwon DS, Markowitz SD, Milne GL, Nishioka NS, Richter JM, Roy HK, Staller K, Wang M, Chan AT. ASPirin Intervention for the REDuction of colorectal cancer risk (ASPIRED): a study protocol for a randomized controlled trial. Trials. 2017 02 01; 18(1):50. PMID: 28143522.
    Citations: 7     Fields:    Translation:Humans
  17. Gootenberg DB, Paer JM, Luevano JM, Kwon DS. HIV-associated changes in the enteric microbial community: potential role in loss of homeostasis and development of systemic inflammation. Curr Opin Infect Dis. 2017 02; 30(1):31-43. PMID: 27922852.
    Citations: 7     Fields:    Translation:HumansCells
  18. Gosmann C, Anahtar MN, Handley SA, Farcasanu M, Abu-Ali G, Bowman BA, Padavattan N, Desai C, Droit L, Moodley A, Dong M, Chen Y, Ismail N, Ndung'u T, Ghebremichael MS, Wesemann DR, Mitchell C, Dong KL, Huttenhower C, Walker BD, Virgin HW, Kwon DS. Lactobacillus-Deficient Cervicovaginal Bacterial Communities Are Associated with Increased HIV Acquisition in Young South African Women. Immunity. 2017 01 17; 46(1):29-37. PMID: 28087240.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  19. Kleinsteuber K, Corleis B, Rashidi N, Nchinda N, Lisanti A, Cho JL, Medoff BD, Kwon D, Walker BD. Standardization and quality control for high-dimensional mass cytometry studies of human samples. Cytometry A. 2016 10; 89(10):903-913. PMID: 27575385.
    Citations: 6     Fields:    Translation:HumansCells
  20. Anahtar MN, Bowman BA, Kwon DS. Efficient Nucleic Acid Extraction and 16S rRNA Gene Sequencing for Bacterial Community Characterization. J Vis Exp. 2016 04 14; (110). PMID: 27168460.
    Citations: 3     Fields:    Translation:HumansCells
  21. Monaco CL, Gootenberg DB, Zhao G, Handley SA, Ghebremichael MS, Lim ES, Lankowski A, Baldridge MT, Wilen CB, Flagg M, Norman JM, Keller BC, Luévano JM, Wang D, Boum Y, Martin JN, Hunt PW, Bangsberg DR, Siedner MJ, Kwon DS, Virgin HW. Altered Virome and Bacterial Microbiome in Human Immunodeficiency Virus-Associated Acquired Immunodeficiency Syndrome. Cell Host Microbe. 2016 Mar 09; 19(3):311-22. PMID: 26962942.
    Citations: 47     Fields:    Translation:HumansCells
  22. Gandhi RT, Kwon DS, Macklin EA, Shopis JR, McLean AP, McBrine N, Flynn T, Peter L, Sbrolla A, Kaufmann DE, Porichis F, Walker BD, Bhardwaj N, Barouch DH, Kavanagh DG. Immunization of HIV-1-Infected Persons With Autologous Dendritic Cells Transfected With mRNA Encoding HIV-1 Gag and Nef: Results of a Randomized, Placebo-Controlled Clinical Trial. J Acquir Immune Defic Syndr. 2016 Mar 01; 71(3):246-53. PMID: 26379068; PMCID: PMC4752409.
    Citations: 3     Fields:    Translation:HumansCellsPHPublic Health
  23. Riou C, Strickland N, Soares AP, Corleis B, Kwon DS, Wherry EJ, Wilkinson RJ, Burgers WA. HIV Skews the Lineage-Defining Transcriptional Profile of Mycobacterium tuberculosis-Specific CD4+ T Cells. J Immunol. 2016 Apr 01; 196(7):3006-18. PMID: 26927799.
    Citations: 6     Fields:    Translation:HumansCells
  24. Siedner MJ, Kim JH, Nakku RS, Hemphill L, Triant VA, Haberer JE, Martin JN, Boum Y, Kwon DS, Tsai AC, Hunt PW, Okello S, Bangsberg DR. HIV infection and arterial stiffness among older-adults taking antiretroviral therapy in rural Uganda. AIDS. 2016 Feb 20; 30(4):667-70. PMID: 26636926; PMCID: PMC4733585.
    Citations: 5     Fields:    Translation:Humans
  25. Sips M, Krykbaeva M, Diefenbach TJ, Ghebremichael M, Bowman BA, Dugast AS, Boesch AW, Streeck H, Kwon DS, Ackerman ME, Suscovich TJ, Brouckaert P, Schacker TW, Alter G. Fc receptor-mediated phagocytosis in tissues as a potent mechanism for preventive and therapeutic HIV vaccine strategies. Mucosal Immunol. 2016 11; 9(6):1584-1595. PMID: 26883728.
    Citations: 22     Fields:    Translation:HumansCells
  26. Byrne EH, Anahtar MN, Cohen KE, Moodley A, Padavattan N, Ismail N, Bowman BA, Olson GS, Mabhula A, Leslie A, Ndung'u T, Walker BD, Ghebremichael MS, Dong KL, Kwon DS. Association between injectable progestin-only contraceptives and HIV acquisition and HIV target cell frequency in the female genital tract in South African women: a prospective cohort study. Lancet Infect Dis. 2016 Apr; 16(4):441-8. PMID: 26723758.
    Citations: 16     Fields:    Translation:HumansCells
  27. Siedner MJ, Kim JH, Nakku RS, Bibangambah P, Hemphill L, Triant VA, Haberer JE, Martin JN, Mocello AR, Boum Y, Kwon DS, Tracy RP, Burdo T, Huang Y, Cao H, Okello S, Bangsberg DR, Hunt PW. Persistent Immune Activation and Carotid Atherosclerosis in HIV-Infected Ugandans Receiving Antiretroviral Therapy. J Infect Dis. 2016 Feb 01; 213(3):370-8. PMID: 26347573; PMCID: PMC4704672.
    Citations: 20     Fields:    Translation:Humans
  28. Adoro S, Cubillos-Ruiz JR, Chen X, Deruaz M, Vrbanac VD, Song M, Park S, Murooka TT, Dudek TE, Luster AD, Tager AM, Streeck H, Bowman B, Walker BD, Kwon DS, Lazarevic V, Glimcher LH. IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection. Nat Commun. 2015 Jun 25; 6:7562. PMID: 26108174; PMCID: PMC4481879.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  29. Anahtar MN, Byrne EH, Doherty KE, Bowman BA, Yamamoto HS, Soumillon M, Padavattan N, Ismail N, Moodley A, Sabatini ME, Ghebremichael MS, Nusbaum C, Huttenhower C, Virgin HW, Ndung'u T, Dong KL, Walker BD, Fichorova RN, Kwon DS. Cervicovaginal bacteria are a major modulator of host inflammatory responses in the female genital tract. Immunity. 2015 May 19; 42(5):965-76. PMID: 25992865; PMCID: PMC4461369.
    Citations: 65     Fields:    Translation:HumansCells
  30. Corleis B, Lisanti A, Korner C, Amero MA, Rosenberg ES, Allen TM, Altfeld M, Kwon DS. Protective Role of TLR3 Induced Human Beta Defensins during Acute HIV-1 Infection. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A124-5. PMID: 25357346.
    Citations:    
  31. Sips M, Krykbaeva M, Bowman B, Diefenbach T, Kwon D, Brouckaert P, Alter G. Targeting Mucosal Fc-Fc Receptor Interactions as Vaccine Strategy against Mucosal HIV-transmission. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A63. PMID: 25357904.
    Citations:    
  32. Byrne EH, Anahtar M, Doherty K, Olson G, Bowman B, Padavattan N, Ndhlovu Z, Ghebremichael M, Walker B, Ndung'u T, Dong K, Kwon DS. Injectable Contraceptive Use Correlates with Increased HIV Target Cells at the Cervix in Young South African Women. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A54-5. PMID: 25357881.
    Citations:    
  33. Doherty KE, Anahtar M, Ghebremichael M, Thogabekale C, Padavattan N, Dong K, Walker BD, Ndung'u T, Kwon DS. Effects of Intra-vaginal Drying Agents on Mucosal Immune Activation and Risk for HIV Acquisition in South African Women. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A230-1. PMID: 25357647.
    Citations:    
  34. Ogunniyi AO, Thomas BA, Politano TJ, Varadarajan N, Landais E, Poignard P, Walker BD, Kwon DS, Love JC. Profiling human antibody responses by integrated single-cell analysis. Vaccine. 2014 May 19; 32(24):2866-73. PMID: 24602776; PMCID: PMC4164152.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  35. Angin M, Klarenbeek PL, King M, Sharma SM, Moodley ES, Rezai A, Piechocka-Trocha A, Toth I, Chan AT, Goulder PJ, Ndung'u T, Kwon DS, Addo MM. Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. PLoS One. 2014; 9(2):e86920. PMID: 24498287; PMCID: PMC3911933.
    Citations: 4     Fields:    Translation:HumansCells
  36. Ladinsky MS, Kieffer C, Olson G, Deruaz M, Vrbanac V, Tager AM, Kwon DS, Bjorkman PJ. Electron tomography of HIV-1 infection in gut-associated lymphoid tissue. PLoS Pathog. 2014 Jan; 10(1):e1003899. PMID: 24497830; PMCID: PMC3907528.
    Citations: 11     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  37. Porichis F, Hart MG, Zupkosky J, Barblu L, Kwon DS, McMullen A, Brennan T, Ahmed R, Freeman GJ, Kavanagh DG, Kaufmann DE. Differential impact of PD-1 and/or interleukin-10 blockade on HIV-1-specific CD4 T cell and antigen-presenting cell functions. J Virol. 2014 Mar; 88(5):2508-18. PMID: 24352453; PMCID: PMC3958087.
    Citations: 23     Fields:    Translation:HumansCells
  38. Vaidya SA, Streeck H, Beckwith N, Ghebremichael M, Pereyra F, Kwon DS, Addo MM, Rychert J, Routy JP, Jessen H, Kelleher AD, Hecht F, Sekaly RP, Carrington M, Walker BD, Allen TM, Rosenberg ES, Altfeld M. Temporal effect of HLA-B*57 on viral control during primary HIV-1 infection. Retrovirology. 2013 Nov 18; 10:139. PMID: 24245727; PMCID: PMC3874665.
    Citations: 4     Fields:    Translation:HumansCells
  39. Adalsteinsson VA, Tahirova N, Tallapragada N, Yao X, Campion L, Angelini A, Douce TB, Huang C, Bowman B, Williamson CA, Kwon DS, Wittrup KD, Love JC. Single cells from human primary colorectal tumors exhibit polyfunctional heterogeneity in secretions of ELR+ CXC chemokines. Integr Biol (Camb). 2013 Oct; 5(10):1272-81. PMID: 23995780; PMCID: PMC4034677.
    Citations: 4     Fields:    Translation:HumansCells
  40. Kwon DS, Angin M, Hongo T, Law KM, Johnson J, Porichis F, Hart MG, Pavlik DF, Tighe DP, Kavanagh DG, Streeck H, Addo MM, Kaufmann DE. CD4+ CD25+ regulatory T cells impair HIV-1-specific CD4 T cell responses by upregulating interleukin-10 production in monocytes. J Virol. 2012 Jun; 86(12):6586-94. PMID: 22496237; PMCID: PMC3393541.
    Citations: 16     Fields:    Translation:HumansCells
  41. Angin M, Kwon DS, Streeck H, Wen F, King M, Rezai A, Law K, Hongo TC, Pyo A, Piechocka-Trocha A, Toth I, Pereyra F, Ghebremichael M, Rodig SJ, Milner DA, Richter JM, Altfeld M, Kaufmann DE, Walker BD, Addo MM. Preserved function of regulatory T cells in chronic HIV-1 infection despite decreased numbers in blood and tissue. J Infect Dis. 2012 May 15; 205(10):1495-500. PMID: 22427677; PMCID: PMC3415814.
    Citations: 26     Fields:    Translation:HumansCells
  42. Varadarajan N, Kwon DS, Law KM, Ogunniyi AO, Anahtar MN, Richter JM, Walker BD, Love JC. Rapid, efficient functional characterization and recovery of HIV-specific human CD8+ T cells using microengraving. Proc Natl Acad Sci U S A. 2012 Mar 06; 109(10):3885-90. PMID: 22355106; PMCID: PMC3309713.
    Citations: 41     Fields:    Translation:HumansCells
  43. Porichis F, Kwon DS, Zupkosky J, Tighe DP, McMullen A, Brockman MA, Pavlik DF, Rodriguez-Garcia M, Pereyra F, Freeman GJ, Kavanagh DG, Kaufmann DE. Responsiveness of HIV-specific CD4 T cells to PD-1 blockade. Blood. 2011 Jul 28; 118(4):965-74. PMID: 21652684; PMCID: PMC3148173.
    Citations: 62     Fields:    Translation:HumansCells
  44. Streeck H, Kwon DS, Pyo A, Flanders M, Chevalier MF, Law K, Jülg B, Trocha K, Jolin JS, Anahtar MN, Lian J, Toth I, Brumme Z, Chang JJ, Caron T, Rodig SJ, Milner DA, Piechoka-Trocha A, Kaufmann DE, Walker BD, Altfeld M. Epithelial adhesion molecules can inhibit HIV-1-specific CD8? T-cell functions. Blood. 2011 May 12; 117(19):5112-22. PMID: 21403126; PMCID: PMC3109536.
    Citations: 9     Fields:    Translation:HumansCells
  45. Pereyra F, Jia X, McLaren PJ, Telenti A, de Bakker PI, Walker BD, Ripke S, Brumme CJ, Pulit SL, Carrington M, Kadie CM, Carlson JM, Heckerman D, Graham RR, Plenge RM, Deeks SG, Gianniny L, Crawford G, Sullivan J, Gonzalez E, Davies L, Camargo A, Moore JM, Beattie N, Gupta S, Crenshaw A, Burtt NP, Guiducci C, Gupta N, Gao X, Qi Y, Yuki Y, Piechocka-Trocha A, Cutrell E, Rosenberg R, Moss KL, Lemay P, O'Leary J, Schaefer T, Verma P, Toth I, Block B, Baker B, Rothchild A, Lian J, Proudfoot J, Alvino DM, Vine S, Addo MM, Allen TM, Altfeld M, Henn MR, Le Gall S, Streeck H, Haas DW, Kuritzkes DR, Robbins GK, Shafer RW, Gulick RM, Shikuma CM, Haubrich R, Riddler S, Sax PE, Daar ES, Ribaudo HJ, Agan B, Agarwal S, Ahern RL, Allen BL, Altidor S, Altschuler EL, Ambardar S, Anastos K, Anderson B, Anderson V, Andrady U, Antoniskis D, Bangsberg D, Barbaro D, Barrie W, Bartczak J, Barton S, Basden P, Basgoz N, Bazner S, Bellos NC, Benson AM, Berger J, Bernard NF, Bernard AM, Birch C, Bodner SJ, Bolan RK, Boudreaux ET, Bradley M, Braun JF, Brndjar JE, Brown SJ, Brown K, Brown ST, Burack J, Bush LM, Cafaro V, Campbell O, Campbell J, Carlson RH, Carmichael JK, Casey KK, Cavacuiti C, Celestin G, Chambers ST, Chez N, Chirch LM, Cimoch PJ, Cohen D, Cohn LE, Conway B, Cooper DA, Cornelson B, Cox DT, Cristofano MV, Cuchural G, Czartoski JL, Dahman JM, Daly JS, Davis BT, Davis K, Davod SM, DeJesus E, Dietz CA, Dunham E, Dunn ME, Ellerin TB, Eron JJ, Fangman JJ, Farel CE, Ferlazzo H, Fidler S, Fleenor-Ford A, Frankel R, Freedberg KA, French NK, Fuchs JD, Fuller JD, Gaberman J, Gallant JE, Gandhi RT, Garcia E, Garmon D, Gathe JC, Gaultier CR, Gebre W, Gilman FD, Gilson I, Goepfert PA, Gottlieb MS, Goulston C, Groger RK, Gurley TD, Haber S, Hardwicke R, Hardy WD, Harrigan PR, Hawkins TN, Heath S, Hecht FM, Henry WK, Hladek M, Hoffman RP, Horton JM, Hsu RK, Huhn GD, Hunt P, Hupert MJ, Illeman ML, Jaeger H, Jellinger RM, John M, Johnson JA, Johnson KL, Johnson H, Johnson K, Joly J, Jordan WC, Kauffman CA, Khanlou H, Killian RK, Kim AY, Kim DD, Kinder CA, Kirchner JT, Kogelman L, Kojic EM, Korthuis PT, Kurisu W, Kwon DS, LaMar M, Lampiris H, Lanzafame M, Lederman MM, Lee DM, Lee JM, Lee MJ, Lee ET, Lemoine J, Levy JA, Llibre JM, Liguori MA, Little SJ, Liu AY, Lopez AJ, Loutfy MR, Loy D, Mohammed DY, Man A, Mansour MK, Marconi VC, Markowitz M, Marques R, Martin JN, Martin HL, Mayer KH, McElrath MJ, McGhee TA, McGovern BH, McGowan K, McIntyre D, Mcleod GX, Menezes P, Mesa G, Metroka CE, Meyer-Olson D, Miller AO, Montgomery K, Mounzer KC, Nagami EH, Nagin I, Nahass RG, Nelson MO, Nielsen C, Norene DL, O'Connor DH, Ojikutu BO, Okulicz J, Oladehin OO, Oldfield EC, Olender SA, Ostrowski M, Owen WF, Pae E, Parsonnet J, Pavlatos AM, Perlmutter AM, Pierce MN, Pincus JM, Pisani L, Price LJ, Proia L, Prokesch RC, Pujet HC, Ramgopal M, Rathod A, Rausch M, Ravishankar J, Rhame FS, Richards CS, Richman DD, Rodes B, Rodriguez M, Rose RC, Rosenberg ES, Rosenthal D, Ross PE, Rubin DS, Rumbaugh E, Saenz L, Salvaggio MR, Sanchez WC, Sanjana VM, Santiago S, Schmidt W, Schuitemaker H, Sestak PM, Shalit P, Shay W, Shirvani VN, Silebi VI, Sizemore JM, Skolnik PR, Sokol-Anderson M, Sosman JM, Stabile P, Stapleton JT, Starrett S, Stein F, Stellbrink HJ, Sterman FL, Stone VE, Stone DR, Tambussi G, Taplitz RA, Tedaldi EM, Telenti A, Theisen W, Torres R, Tosiello L, Tremblay C, Tribble MA, Trinh PD, Tsao A, Ueda P, Vaccaro A, Valadas E, Vanig TJ, Vecino I, Vega VM, Veikley W, Wade BH, Walworth C, Wanidworanun C, Ward DJ, Warner DA, Weber RD, Webster D, Weis S, Wheeler DA, White DJ, Wilkins E, Winston A, Wlodaver CG, van't Wout A, Wright DP, Yang OO, Yurdin DL, Zabukovic BW, Zachary KC, Zeeman B, Zhao M. The major genetic determinants of HIV-1 control affect HLA class I peptide presentation. Science. 2010 Dec 10; 330(6010):1551-7. PMID: 21051598.
    Citations: 466     Fields:    Translation:HumansCells
  46. Chevalier MF, Jülg B, Pyo A, Flanders M, Ranasinghe S, Soghoian DZ, Kwon DS, Rychert J, Lian J, Muller MI, Cutler S, McAndrew E, Jessen H, Pereyra F, Rosenberg ES, Altfeld M, Walker BD, Streeck H. HIV-1-specific interleukin-21+ CD4+ T cell responses contribute to durable viral control through the modulation of HIV-specific CD8+ T cell function. J Virol. 2011 Jan; 85(2):733-41. PMID: 21047960; PMCID: PMC3020027.
    Citations: 84     Fields:    Translation:HumansCells
  47. Quigley M, Pereyra F, Nilsson B, Porichis F, Fonseca C, Eichbaum Q, Julg B, Jesneck JL, Brosnahan K, Imam S, Russell K, Toth I, Piechocka-Trocha A, Dolfi D, Angelosanto J, Crawford A, Shin H, Kwon DS, Zupkosky J, Francisco L, Freeman GJ, Wherry EJ, Kaufmann DE, Walker BD, Ebert B, Haining WN. Transcriptional analysis of HIV-specific CD8+ T cells shows that PD-1 inhibits T cell function by upregulating BATF. Nat Med. 2010 Oct; 16(10):1147-51. PMID: 20890291; PMCID: PMC3326577.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  48. Kwon DS, Kaufmann DE. Protective and detrimental roles of IL-10 in HIV pathogenesis. Eur Cytokine Netw. 2010 Sep; 21(3):208-14. PMID: 20732847.
    Citations: 9     Fields:    Translation:HumansCells
  49. Streeck H, Jolin JS, Qi Y, Yassine-Diab B, Johnson RC, Kwon DS, Addo MM, Brumme C, Routy JP, Little S, Jessen HK, Kelleher AD, Hecht FM, Sekaly RP, Rosenberg ES, Walker BD, Carrington M, Altfeld M. Human immunodeficiency virus type 1-specific CD8+ T-cell responses during primary infection are major determinants of the viral set point and loss of CD4+ T cells. J Virol. 2009 Aug; 83(15):7641-8. PMID: 19458000.
    Citations: 94     Fields:    Translation:HumansCells
  50. Brockman MA, Kwon DS, Tighe DP, Pavlik DF, Rosato PC, Sela J, Porichis F, Le Gall S, Waring MT, Moss K, Jessen H, Pereyra F, Kavanagh DG, Walker BD, Kaufmann DE. IL-10 is up-regulated in multiple cell types during viremic HIV infection and reversibly inhibits virus-specific T cells. Blood. 2009 Jul 09; 114(2):346-56. PMID: 19365081; PMCID: PMC2714209.
    Citations: 102     Fields:    Translation:HumansCells
  51. Kwon DS, Mylonakis E. Posaconazole: a new broad-spectrum antifungal agent. Expert Opin Pharmacother. 2007 Jun; 8(8):1167-78. PMID: 17516880.
    Citations: 11     Fields:    Translation:HumansAnimals
  52. Kwon DS, Gregorio G, Bitton N, Hendrickson WA, Littman DR. DC-SIGN-mediated internalization of HIV is required for trans-enhancement of T cell infection. Immunity. 2002 Jan; 16(1):135-44. PMID: 11825572.
    Citations: 177     Fields:    Translation:HumansCells
  53. Geijtenbeek TB, Kwon DS, Torensma R, van Vliet SJ, van Duijnhoven GC, Middel J, Cornelissen IL, Nottet HS, KewalRamani VN, Littman DR, Figdor CG, van Kooyk Y. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell. 2000 Mar 03; 100(5):587-97. PMID: 10721995.
    Citations: 682     Fields:    Translation:HumansCells
  54. Zhang YJ, Dragic T, Cao Y, Kostrikis L, Kwon DS, Littman DR, KewalRamani VN, Moore JP. Use of coreceptors other than CCR5 by non-syncytium-inducing adult and pediatric isolates of human immunodeficiency virus type 1 is rare in vitro. J Virol. 1998 Nov; 72(11):9337-44. PMID: 9765485; PMCID: PMC110357.
    Citations: 45     Fields:    Translation:HumansCells
  55. Hill CM, Kwon D, Jones M, Davis CB, Marmon S, Daugherty BL, DeMartino JA, Springer MS, Unutmaz D, Littman DR. The amino terminus of human CCR5 is required for its function as a receptor for diverse human and simian immunodeficiency virus envelope glycoproteins. Virology. 1998 Sep 01; 248(2):357-71. PMID: 9721244.
    Citations: 26     Fields:    Translation:HumansCells
  56. Kleckner N, Chalmers RM, Kwon D, Sakai J, Bolland S. Tn10 and IS10 transposition and chromosome rearrangements: mechanism and regulation in vivo and in vitro. Curr Top Microbiol Immunol. 1996; 204:49-82. PMID: 8556869.
    Citations: 30     Fields:    Translation:Cells
  57. Kwon D, Chalmers RM, Kleckner N. Structural domains of IS10 transposase and reconstitution of transposition activity from proteolytic fragments lacking an interdomain linker. Proc Natl Acad Sci U S A. 1995 Aug 29; 92(18):8234-8. PMID: 7667274; PMCID: PMC41131.
    Citations: 4     Fields:    Translation:Cells
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.