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Douglas Kwon, M.D.,Ph.D.

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Biography
2009
International Congress of Mucosal Immunology Young Investigator Award
2011
Burrough Wellcome Fund Career Award for Medical Scientists
2011
Maxwell Finland Research Award
2012
Faculty of 1000
2014
Harvard Medical School Young Mentor Award
2015
MIT Sloan GE Ventures Finalist
2016
Harvard Business School New Ventures Award
2016
Medicine Innovation Award
2017
Swartz Transformative Scholar Award
2017
NIAID Top Women’s Health Science
2017
Wellman Foundation Award
2017
MedTech Innovator National Winner
2018
Nominee Trailblazer Prize for Clinician-Scientists, Foundation for the National Institutes of Health
2019
American Society of Clinical Investigation Inductee

Overview
Our research focuses on the investigation of immune responses against HIV at mucosal surfaces. The vast majority of HIV is transmitted following exposure to virus at a mucosal site. Mucosal tissues, particularly gut associated lymphoid tissue (GALT), also represents the main compartment of viral replication and the largest reservoir of latently infected cells. Despite this, HIV pathogenesis has primarily been studied in the most accessible compartment- the peripheral blood. However, only 2-3% of all lymphocytes reside in the blood- a small minority relative to the 70-90% of the body’s T and B cells that reside within mucosal tissues. One of the bottlenecks to obtaining a deeper understanding of immune responses against HIV at mucosal sites is the inherently small amount of material that can be obtained from mucosal sampling. We are therefore utilizing new cutting-edge technologies to simultaneously capture multiple measures of HIV-specific immune responses using small numbers of cells. Using these methodologies we have begun to map mucosal immune responses in the GALT and female reproductive tract at a level of resolution that has not been previously possible with existing technologies. We have also characterized how the microbiome at these mucosal surfaces impacts HIV acquisition and disease progression.
See more details at: kwonlab.org

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK133919 (KWON, DOUGLAS) Aug 1, 2022 - Jun 30, 2027
    NIH
    Immunometabolic regulation of CD8+ T cell mediated intestinal epithelial cell death in people with HIV (PWH)
    Role: Principal Investigator
  2. R01DK126545 (KWON, DOUGLAS) Jul 1, 2020 - Jun 30, 2025
    NIH
    Mechanisms of HIV-associated epithelialintestinal stem cell (ISC) dysfunction
    Role: Principal Investigator
  3. R01HD098978 (COHEN, CRAIG R) Jun 12, 2019 - Mar 31, 2023
    NIH
    Phase 2 placebo-controlled randomized trial of LACTIN-V (Lactobacillus crispatus CTV-05) among women at high risk of HIV acquisition in Durban, South Africa
    Role: Co-Investigator
  4. (Collins, Jim) Jun 1, 2019 - May 31, 2021
    Ragon Institute
    Synthetic biology platform for simple, low-cost HIV detection and monitoring
  5. (Kwon, Douglas) Oct 1, 2018 - Sep 20, 2022
    Ragon Institute
    Impact of the vaginal microbiome on HVTN705 vaccine efficacy
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.