Title Associate Professor of Medicine Institution Massachusetts General Hospital Address Massachusetts General Hospital Ragon Institute of MGH, MIT, and Harvard 400 Technology Square, Room 892 Cambridge MA 02139
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Biography
2009
International Congress of Mucosal Immunology Young Investigator Award
2011
Burrough Wellcome Fund Career Award for Medical Scientists
2011
Maxwell Finland Research Award
2014
Harvard Medical School Young Mentor Award
2015
MIT Sloan GE Ventures Finalist
2016
Harvard Business School New Ventures Award
2016
Medicine Innovation Award
2017
Swartz Transformative Scholar Award
2017
NIAID Top Women’s Health Science
2017
Wellman Foundation Award
2017
MedTech Innovator National Winner
2018
Nominee Trailblazer Prize for Clinician-Scientists, Foundation for the National Institutes of Health
2019
American Society of Clinical Investigation Inductee

Overview
Our research focuses on the investigation of immune responses against HIV at mucosal surfaces. The vast majority of HIV is transmitted following exposure to virus at a mucosal site. Mucosal tissues, particularly gut associated lymphoid tissue (GALT), also represents the main compartment of viral replication and the largest reservoir of latently infected cells. Despite this, HIV pathogenesis has primarily been studied in the most accessible compartment- the peripheral blood. However, only 2-3% of all lymphocytes reside in the blood- a small minority relative to the 70-90% of the body’s T and B cells that reside within mucosal tissues. One of the bottlenecks to obtaining a deeper understanding of immune responses against HIV at mucosal sites is the inherently small amount of material that can be obtained from mucosal sampling. We are therefore utilizing new cutting-edge technologies to simultaneously capture multiple measures of HIV-specific immune responses using small numbers of cells. Using these methodologies we have begun to map mucosal immune responses in the GALT and female reproductive tract at a level of resolution that has not been previously possible with existing technologies. We have also characterized how the microbiome at these mucosal surfaces impacts HIV acquisition and disease progression.
See more details at: kwonlab.org

Research
The research activities and funding listed below are automatically derived from
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R01DK126545
(KWON, DOUGLAS)
Jul 1, 2020 - Jun 30, 2025
Mechanisms of HIV-associated epithelial intestinal stem cell (ISC) dysfunction
Role: Principal Investigator
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R01HD098978
(COHEN, CRAIG R)
Jun 12, 2019 - Mar 31, 2023
Phase 2 placebo-controlled randomized trial of LACTIN-V (Lactobacillus crispatus CTV-05) among women at high risk of HIV acquisition in Durban, South Africa
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(Collins, Jim)
Jun 1, 2019 - May 31, 2021
Synthetic biology platform for simple, low-cost HIV detection and monitoring
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(Kwon, Douglas)
Oct 1, 2018 - Sep 20, 2022
Impact of the vaginal microbiome on HVTN705 vaccine efficacy
Role: Principal Investigator
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R01DK120485
(KWON, DOUGLAS)
Sep 14, 2018 - Aug 31, 2023
Multi-omics characterization of HIV-associated changes in the gut microbiome and host mucosal immunity
Role: Principal Investigator
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R01HL138646
(KWON, DOUGLAS)
Sep 1, 2017 - May 31, 2021
The enteric microbiome in HIV-associated chronic immune activation and cardiovascular disease
Role: Principal Investigator
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(KWON, DOUGLAS)
Sep 1, 2016 - Aug 31, 2022
Bill and Melinda Gates Foundation
Role: Project Principal Investigator
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R01DA042685
(LIN, NINA)
Aug 15, 2016 - Jun 30, 2021
Impact of smoking and its cessation on systemic and airway immune activation
Role: Consortium Principal Investigator
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(WALKER, BRUCE)
Aug 1, 2016 - Aug 1, 2020
Harvard University Center for AIDS Research
Role: Associate Director, Harvard CFAR
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NIH R01 CA137178
(CHAN, ANDREW)
Jun 30, 2015 - Jul 1, 2020
Inflammation and Colorectal Neoplasia
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NIH R01AI108538
(TSIBRIS, ATHE)
Aug 31, 2014 - Sep 1, 2019
HIV-1 reservoir dynamics in the female genital tract
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R01DK101354
(KWON, DOUGLAS)
Jul 10, 2014 - Dec 31, 2019
The enteric microbiome in treated and progressive HIV infection
Role: Principal Investigator
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(KWON, DOUGLAS)
Jun 30, 2014 - Jul 1, 2018
Effects of HIV infection on M. tuberculosis killing and growth in human alveolar macrophages
Role: Principal Investigator
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R01AI111918
(KWON, DOUGLAS)
Mar 11, 2014 - Feb 28, 2019
Inflammation and the vaginal metagenome in HIV acquisition
Role: Principal Investigator
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U01HL121827
(MEDOFF, BENJAMIN D)
Sep 26, 2013 - Aug 31, 2019
HIV and COPD:Immune mediated mechanisms
Role: Principal Investigator
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(KWON, DOUGLAS)
Sep 1, 2011 - Aug 31, 2017
Career Award for Medical Scientists
Role: Principal Investigator
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K08AI084546
(KWON, DOUGLAS)
Sep 11, 2009 - Jul 31, 2013
Gut mucosal immunity to HIV-1 in controlled and progressive infection
Role: Principal Investigator

Bibliographic
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