Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Matthew Nathan, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01DK098246 (LACHIN, JOHN M) Sep 25, 2012 - Jul 31, 2023
    Continuation of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness (GRADE) Study
    Role: Co-Principal Investigator
  2. U34DK088043 (NATHAN, DAVID M) Sep 28, 2010 - Nov 30, 2012
    Glycemic Reduction Approaches for Treating Diabetes: An Effectiveness Study
    Role: Principal Investigator
  3. U01DK057154 (NATHAN, DAVID M) Sep 30, 1999 - Jan 31, 2021
    04/16 Action for Health in Diabetes Extension Study Research Project
    Role: Principal Investigator
  4. U01DK048397 (NATHAN, DAVID M) Aug 20, 1994 - Jan 31, 2022
    11/22 Limited Competition for the Continuation of the Diabetes Prevention Program Outcomes Study (DPPOS) - Clinical Center
    Role: Principal Investigator
  5. U01DK030643 (NATHAN, DAVID M) Mar 1, 1982 - Feb 28, 1999
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Wing RR, Bray GA, Cassidy-Begay M, Clark JM, Coday M, Egan C, Evans M, Foreyt JP, Glasser S, Gregg EW, Hazuda HP, Hill JO, Horton ES, Isaac JC, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Kritchevsky S, Lewis E, Maruthur NM, Maschak-Carey BJ, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Reboussin D, Ryan DH, Ruelas V, Steinburg H, Toledo K, Wadden TA, Wagenknecht LE, Wesche-Thobaben J, Wyatt H, Yanovski SZ, Zhang P. Effects of Intensive Lifestyle Intervention on All-Cause Mortality in Older Adults With Type 2 Diabetes and Overweight/Obesity: Results From the Look AHEAD Study. Diabetes Care. 2022 Mar 21. PMID: 35312758.
    Citations:    Fields:    
  2. Nathan DM, Buse JB, Kahn SE, Krause-Steinrauf H, Larkin ME, Staten M, Wexler D, Lachin JM. Erratum. Rationale and Design of the Glycemia Reduction Approaches in Diabetes: A Comparative Effectiveness Study (GRADE). Diabetes Care 2013;36:2254-2261. Diabetes Care. 2022 Mar 01; 45(3):759. PMID: 35020815.
    Citations:    Fields:    
  3. Jakicic JM, Berkowitz RI, Bolin P, Bray GA, Clark JM, Coday M, Egan C, Evans M, Foreyt JP, Fulton JE, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Jeffery RW, Johnson KC, Johnson R, Kahn SE, Kure A, Lang W, Lewis CE, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Rejeski WJ, Safford M, Stewart KJ, Wadden TA, Walkup MP, Wing RR, Wyatt H. Association Between Change in Accelerometer-Measured and Self-Reported Physical Activity and Cardiovascular Disease in the Look AHEAD Trial. Diabetes Care. 2022 03 01; 45(3):742-749. PMID: 35019976.
    Citations:    Fields:    Translation:Humans
  4. O'Connell J, Nathan DM, O'Brien T, O'Keeffe DT. Treatment of Diabetes - To Pump or Not to Pump. N Engl J Med. 2021 Nov 25; 385(22):2092-2095. PMID: 34818486.
    Citations:    Fields:    Translation:Humans
  5. Nathan DM, Krause-Steinrauf H, Braffett BH, Arends VL, Younes N, McGee P, Lund C, Johnson M, Lorenzi G, Gao X, Steffes MW, Lachin JM. Comparison of central laboratory HbA1c measurements obtained from a capillary collection versus a standard venous whole blood collection in the GRADE and EDIC studies. PLoS One. 2021; 16(11):e0257154. PMID: 34780485.
    Citations:    Fields:    Translation:Humans
  6. Lachin JM, Nathan DM. Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC). Diabetes Care. 2021 Sep 21. PMID: 34548284.
    Citations: 1     Fields:    
  7. Lachin JM, Bebu I, Nathan DM. The Beneficial Effects of Earlier Versus Later Implementation of Intensive Therapy in Type 1 Diabetes. Diabetes Care. 2021 Aug 11. PMID: 34380706.
    Citations: 2     Fields:    
  8. Bjornstad P, Drews KL, Caprio S, Gubitosi-Klug R, Nathan DM, Tesfaldet B, Tryggestad J, White NH, Zeitler P. Long-Term Complications in Youth-Onset Type 2 Diabetes. N Engl J Med. 2021 07 29; 385(5):416-426. PMID: 34320286.
    Citations: 8     Fields:    Translation:Humans
  9. Bebu I, Keshavarzi S, Gao X, Braffett BH, Canty AJ, Herman WH, Orchard TJ, Dagogo-Jack S, Nathan DM, Lachin JM, Paterson AD. Genetic Risk Factors for CVD in Type 1 Diabetes: The DCCT/EDIC Study. Diabetes Care. 2021 06; 44(6):1309-1316. PMID: 33883194.
    Citations: 1     Fields:    Translation:Humans
  10. Izzy S, Tahir Z, Grashow R, Cote DJ, Jarrah AA, Dhand A, Taylor H, Whalen M, Nathan DM, Miller KK, Speizer F, Baggish A, Weisskopf MG, Zafonte R. Concussion and Risk of Chronic Medical and Behavioral Health Comorbidities. J Neurotrauma. 2021 06 01; 38(13):1834-1841. PMID: 33451255.
    Citations:    Fields:    Translation:Humans
  11. Nathan DM. Realising the long-term promise of insulin therapy: the DCCT/EDIC study. Diabetologia. 2021 05; 64(5):1049-1058. PMID: 33550441.
    Citations: 5     Fields:    Translation:Humans
  12. Bebu I, Braffett BH, Orchard TJ, Lorenzi GM, Nathan DM, Herman WH, Lachin JM. Moderation of the effect of glycemia on the risk of cardiovascular disease in type 1 diabetes: The DCCT/EDIC study. Diabetes Res Clin Pract. 2021 Jan; 171:108591. PMID: 33310124.
    Citations: 2     Fields:    Translation:Humans
  13. Zhang P, Atkinson KM, Bray GA, Chen H, Clark JM, Coday M, Dutton GR, Egan C, Espeland MA, Evans M, Foreyt JP, Greenway FL, Gregg EW, Hazuda HP, Hill JO, Horton ES, Hubbard VS, Huckfeldt PJ, Jackson SD, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Killean T, Knowler WC, Korytkowski M, Lewis CE, Maruthur NM, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pi-Sunyer X, Pownall H, Redmon B, Rushing JT, Steinburg H, Wadden TA, Wing RR, Wyatt H, Yanovski SZ. Within-Trial Cost-Effectiveness of a Structured Lifestyle Intervention in Adults With Overweight/Obesity and Type 2 Diabetes: Results From the Action for Health in Diabetes (Look AHEAD) Study. Diabetes Care. 2021 01; 44(1):67-74. PMID: 33168654.
    Citations: 1     Fields:    Translation:Humans
  14. Munshi MN, Meneilly GS, Rodríguez-Mañas L, Close KL, Conlin PR, Cukierman-Yaffe T, Forbes A, Ganda OP, Kahn CR, Huang E, Laffel LM, Lee CG, Lee S, Nathan DM, Pandya N, Pratley R, Gabbay R, Sinclair AJ. Diabetes in ageing: pathways for developing the evidence base for clinical guidance. Lancet Diabetes Endocrinol. 2020 10; 8(10):855-867. PMID: 32946822.
    Citations: 3     Fields:    Translation:Humans
  15. Yeh HC, Bantle JP, Cassidy-Begay M, Blackburn G, Bray GA, Byers T, Clark JM, Coday M, Egan C, Espeland MA, Foreyt JP, Garcia K, Goldman V, Gregg EW, Hazuda HP, Hesson L, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Johnson KC, Kahn SE, Knowler WC, Korytkowski M, Kure A, Lewis CE, Mantzoros C, Meacham M, Montez MG, Nathan DM, Pajewski N, Patricio J, Peters A, Xavier Pi-Sunyer F, Pownall H, Ryan DH, Safford M, Sedjo RL, Steinburg H, Vitolins M, Wadden TA, Wagenknecht LE, Wing RR, Wolff AC, Wyatt H, Yanovski SZ. Intensive Weight Loss Intervention and Cancer Risk in Adults with Type 2 Diabetes: Analysis of the Look AHEAD Randomized Clinical Trial. Obesity (Silver Spring). 2020 09; 28(9):1678-1686. PMID: 32841523.
    Citations: 7     Fields:    Translation:Humans
  16. Lachin JM, Nathan DM, Zinman B, Bebu I. Comment on Miller and Orchard: Understanding Metabolic Memory: A Tale of Two Studies. Diabetes 2020;69:291-299. Diabetes. 2020 07; 69(7):e7-e8. PMID: 32561623.
    Citations: 3     Fields:    Translation:Humans
  17. Edelson PK, James KE, Leong A, Arenas J, Cayford M, Callahan MJ, Bernstein SN, Tangren JS, Hivert MF, Higgins JM, Nathan DM, Powe CE. Longitudinal Changes in the Relationship Between Hemoglobin A1c and Glucose Tolerance Across Pregnancy and Postpartum. J Clin Endocrinol Metab. 2020 05 01; 105(5). PMID: 32010954.
    Citations: 6     Fields:    Translation:HumansCells
  18. Smetana GW, Nathan DM, Dugdale DC, Burns RB. To What Target Hemoglobin A1c Level Would You Treat This Patient With Type 2 Diabetes?: Grand Rounds Discussion From Beth Israel Deaconess Medical Center. Ann Intern Med. 2019 10 01; 171(7):505-513. PMID: 31569249.
    Citations:    Fields:    Translation:Humans
  19. Larkin ME, Nathan DM, Bebu I, Krause-Steinrauf H, Herman WH, Higgins JM, Tiktin M, Cohen RM, Lund C, Bergenstal RM, Johnson ML, Arends V. Rationale and Design for a GRADE Substudy of Continuous Glucose Monitoring. Diabetes Technol Ther. 2019 12; 21(12):682-690. PMID: 31393176.
    Citations: 2     Fields:    Translation:HumansCTClinical Trials
  20. Nathan DM, Bennett PH, Crandall JP, Edelstein SL, Goldberg RB, Kahn SE, Knowler WC, Mather KJ, Mudaliar S, Orchard TJ, Temprosa M, White NH. Does diabetes prevention translate into reduced long-term vascular complications of diabetes? Diabetologia. 2019 08; 62(8):1319-1328. PMID: 31270584.
    Citations: 13     Fields:    Translation:Humans
  21. Nathan DM, Griffin A, Perez FM, Basque E, Do L, Steiner B. Accuracy of a Point-of-Care Hemoglobin A1c Assay. J Diabetes Sci Technol. 2019 11; 13(6):1149-1153. PMID: 30943787.
    Citations: 2     Fields:    Translation:Humans
  22. Houston DK, Neiberg RH, Miller ME, Hill JO, Jakicic JM, Johnson KC, Gregg EW, Hubbard VS, Pi-Sunyer X, Rejeski WJ, Wing RR, Bantle JP, Beale E, Berkowitz RI, Cassidy-Begay M, Clark JM, Coday M, Delahanty LM, Dutton G, Egan C, Foreyt JP, Greenway FL, Hazuda HP, Hergenroeder A, Horton ES, Jeffery RW, Kahn SE, Kure A, Knowler WC, Lewis CE, Martin CK, Michaels S, Montez MG, Nathan DM, Patricio J, Peters A, Pownall H, Regensteiner J, Steinburg H, Wadden TA, White K, Yanovski SZ, Zhang P, Kritchevsky SB. Physical Function Following a Long-Term Lifestyle Intervention Among Middle Aged and Older Adults With Type 2 Diabetes: The Look AHEAD Study. J Gerontol A Biol Sci Med Sci. 2018 10 08; 73(11):1552-1559. PMID: 29053861.
    Citations: 14     Fields:    Translation:Humans
  23. Nathan DM. Diagnosing diabetes mellitus - best practices still unclear. Nat Rev Endocrinol. 2018 10; 14(10):572-573. PMID: 30054564.
    Citations:    Fields:    Translation:Humans
  24. Draznin B, Nathan DM, Korytkowski MT, McDonnell ME, Golden SH, Schutta MH, Cefalu WT. Guidelines Versus Guidelines: What's Best for the Patient? Ann Intern Med. 2018 08 07; 169(3):186-187. PMID: 29800101.
    Citations:    Fields:    Translation:Humans
  25. Fan W, Zheng H, Wei N, Nathan DM. Estimating HbA1c from timed Self-Monitored Blood Glucose values. Diabetes Res Clin Pract. 2018 Jul; 141:56-61. PMID: 29673846.
    Citations: 3     Fields:    Translation:Humans
  26. Arnold SE, Arvanitakis Z, Macauley-Rambach SL, Koenig AM, Wang HY, Ahima RS, Craft S, Gandy S, Buettner C, Stoeckel LE, Holtzman DM, Nathan DM. Brain insulin resistance in type 2 diabetes and Alzheimer disease: concepts and conundrums. Nat Rev Neurol. 2018 03; 14(3):168-181. PMID: 29377010.
    Citations: 253     Fields:    Translation:Humans
  27. Lachin JM, Bebu I, Bergenstal RM, Pop-Busui R, Service FJ, Zinman B, Nathan DM. Response to Comment on Lachin et al. Association of Glycemic Variability in Type 1 Diabetes With Progression of Microvascular Outcomes in the Diabetes Control and Complications Trial. Diabetes Care 2017;40:777-783. Diabetes Care. 2017 11; 40(11):e165-e166. PMID: 29061594.
    Citations:    Fields:    Translation:Humans
  28. Nathan DM. Adjunctive Treatments for Type 1 Diabetes. N Engl J Med. 2017 12 14; 377(24):2390-2391. PMID: 28899219.
    Citations: 3     Fields:    Translation:Humans
  29. Majithia AR, Wiltschko AB, Zheng H, Walford GA, Nathan DM. Rate of Change of Premeal Glucose Measured by Continuous Glucose Monitoring Predicts Postmeal Glycemic Excursions in Patients With Type 1 Diabetes: Implications for Therapy. J Diabetes Sci Technol. 2018 01; 12(1):76-82. PMID: 28868899.
    Citations: 1     Fields:    Translation:Humans
  30. Aroda VR, Knowler WC, Crandall JP, Perreault L, Edelstein SL, Jeffries SL, Molitch ME, Pi-Sunyer X, Darwin C, Heckman-Stoddard BM, Temprosa M, Kahn SE, Nathan DM. Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study. Diabetologia. 2017 09; 60(9):1601-1611. PMID: 28770322.
    Citations: 36     Fields:    Translation:Humans
  31. Johnson KC, Bray GA, Cheskin LJ, Clark JM, Egan CM, Foreyt JP, Garcia KR, Glasser S, Greenway FL, Gregg EW, Hazuda HP, Hergenroeder A, Hill JO, Horton ES, Jakicic JM, Jeffery RW, Kahn SE, Knowler WC, Lewis CE, Miller M, Montez MG, Nathan DM, Patricio JL, Peters AL, Pi-Sunyer X, Pownall HJ, Reboussin D, Redmon JB, Steinberg H, Wadden TA, Wagenknecht LE, Wing RR, Womack CR, Yanovski SZ, Zhang P, Schwartz AV. The Effect of Intentional Weight Loss on Fracture Risk in Persons With Diabetes: Results From the Look AHEAD Randomized Clinical Trial. J Bone Miner Res. 2017 Nov; 32(11):2278-2287. PMID: 28678345.
    Citations: 26     Fields:    Translation:Humans
  32. Bebu I, Braffett BH, Pop-Busui R, Orchard TJ, Nathan DM, Lachin JM. The relationship of blood glucose with cardiovascular disease is mediated over time by traditional risk factors in type 1 diabetes: the DCCT/EDIC study. Diabetologia. 2017 10; 60(10):2084-2091. PMID: 28711972.
    Citations: 29