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profileAllen Charles Clermont, M.S.

TitleAssociate in Medicine
InstitutionJoslin Diabetes Center
DepartmentMedicine
AddressJoslin Diabetes Center
Eye Unit - 1st Flr.
One Joslin Place
Boston MA 02215
Phone617/732-2568
Fax617/732-2545
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Animal Physiology Core (JDC) - Core services (10) and Instruments (10)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Solheim MH, Clermont AC, Winnay JN, Hallstensen E, Molven A, Njølstad PR, Rødahl E, Kahn CR. Iris Malformation and Anterior Segment Dysgenesis in Mice and Humans With a Mutation in PI 3-Kinase. Invest Ophthalmol Vis Sci. 2017 06 01; 58(7):3100-3106. PMID: 28632845.
    View in: PubMed
  2. Simão F, Ustunkaya T, Clermont AC, Feener EP. Plasma kallikrein mediates brain hemorrhage and edema caused by tissue plasminogen activator therapy in mice after stroke. Blood. 2017 04 20; 129(16):2280-2290. PMID: 28130211.
    View in: PubMed
  3. Moult EM, Choi W, Boas DA, Baumann B, Clermont AC, Feener EP, Fujimoto JG. Evaluating anesthetic protocols for functional blood flow imaging in the rat eye. J Biomed Opt. 2017 01 01; 22(1):16005. PMID: 28056146.
    View in: PubMed
  4. Clermont A, Murugesan N, Zhou Q, Kita T, Robson PA, Rushbrooke LJ, Evans DM, Aiello LP, Feener EP. Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening. Invest Ophthalmol Vis Sci. 2016 05 01; 57(6):2390-9. PMID: 27138737; PMCID: PMC4857835 [Available on 11/01/16].
  5. Long YM, Zhao XC, Clermont AC, Zhou QF, Liu Q, Feener EP, Yan B, Jiang GB. Negatively charged silver nanoparticles cause retinal vascular permeability by activating plasma contact system and disrupting adherens junction. Nanotoxicology. 2016; 10(4):501-11. PMID: 26399585; PMCID: PMC4971575 [Available on 01/01/17].
  6. Kita T, Clermont AC, Murugesan N, Zhou Q, Fujisawa K, Ishibashi T, Aiello LP, Feener EP. Plasma Kallikrein-Kinin System as a VEGF-Independent Mediator of Diabetic Macular Edema. Diabetes. 2015 Oct; 64(10):3588-99. PMID: 25979073; PMCID: PMC4587649 [Available on 10/01/16].
  7. Liu J, Clermont AC, Gao BB, Feener EP. Intraocular hemorrhage causes retinal vascular dysfunction via plasma kallikrein. Invest Ophthalmol Vis Sci. 2013 Feb 07; 54(2):1086-94. PMID: 23299478; PMCID: PMC3567752.
  8. Choi W, Baumann B, Liu JJ, Clermont AC, Feener EP, Duker JS, Fujimoto JG. Measurement of pulsatile total blood flow in the human and rat retina with ultrahigh speed spectral/Fourier domain OCT. Biomed Opt Express. 2012 May 01; 3(5):1047-61. PMID: 22567595; PMCID: PMC3342181.
  9. Rask-Madsen C, Buonomo E, Li Q, Park K, Clermont AC, Yerokun O, Rekhter M, King GL. Hyperinsulinemia does not change atherosclerosis development in apolipoprotein E null mice. Arterioscler Thromb Vasc Biol. 2012 May; 32(5):1124-31. PMID: 22426129; PMCID: PMC3640325.
  10. Clermont A, Chilcote TJ, Kita T, Liu J, Riva P, Sinha S, Feener EP. Plasma kallikrein mediates retinal vascular dysfunction and induces retinal thickening in diabetic rats. Diabetes. 2011 May; 60(5):1590-8. PMID: 21444925; PMCID: PMC3292335.
  11. Liu J, Gao BB, Clermont AC, Blair P, Chilcote TJ, Sinha S, Flaumenhaft R, Feener EP. Hyperglycemia-induced cerebral hematoma expansion is mediated by plasma kallikrein. Nat Med. 2011 Feb; 17(2):206-10. PMID: 21258336; PMCID: PMC3038677.
  12. Walia S, Clermont AC, Gao BB, Aiello LP, Feener EP. Vitreous proteomics and diabetic retinopathy. Semin Ophthalmol. 2010 Sep-Nov; 25(5-6):289-94. PMID: 21091014; PMCID: PMC4996366.
  13. Rask-Madsen C, Li Q, Freund B, Feather D, Abramov R, Wu IH, Chen K, Yamamoto-Hiraoka J, Goldenbogen J, Sotiropoulos KB, Clermont A, Geraldes P, Dall'Osso C, Wagers AJ, Huang PL, Rekhter M, Scalia R, Kahn CR, King GL. Loss of insulin signaling in vascular endothelial cells accelerates atherosclerosis in apolipoprotein E null mice. Cell Metab. 2010 May 05; 11(5):379-89. PMID: 20444418; PMCID: PMC3020149.
  14. Gao BB, Phipps JA, Bursell D, Clermont AC, Feener EP. Angiotensin AT1 receptor antagonism ameliorates murine retinal proteome changes induced by diabetes. J Proteome Res. 2009 Dec; 8(12):5541-9. PMID: 19845401; PMCID: PMC2798584.
  15. Geraldes P, Hiraoka-Yamamoto J, Matsumoto M, Clermont A, Leitges M, Marette A, Aiello LP, Kern TS, King GL. Activation of PKC-delta and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy. Nat Med. 2009 Nov; 15(11):1298-306. PMID: 19881493; PMCID: PMC3290906.
  16. Phipps JA, Clermont AC, Sinha S, Chilcote TJ, Bursell SE, Feener EP. Plasma kallikrein mediates angiotensin II type 1 receptor-stimulated retinal vascular permeability. Hypertension. 2009 Feb; 53(2):175-81. PMID: 19124682; PMCID: PMC4978181.
  17. Geraldes P, Yamagata M, Rook SL, Sassa Y, Ma RC, Clermont A, Gao B, Aiello LP, Feener EP, King GL. Glypican 4, a membrane binding protein for bactericidal/permeability-increasing protein signaling pathways in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2007 Dec; 48(12):5750-5. PMID: 18055828.
    View in: PubMed
  18. Gao BB, Clermont A, Rook S, Fonda SJ, Srinivasan VJ, Wojtkowski M, Fujimoto JG, Avery RL, Arrigg PG, Bursell SE, Aiello LP, Feener EP. Extracellular carbonic anhydrase mediates hemorrhagic retinal and cerebral vascular permeability through prekallikrein activation. Nat Med. 2007 Feb; 13(2):181-8. PMID: 17259996.
    View in: PubMed
  19. Clermont AC, Bursell SE. Retinal blood flow in diabetes. Microcirculation. 2007 Jan; 14(1):49-61. PMID: 17365661.
    View in: PubMed
  20. Srinivasan VJ, Ko TH, Wojtkowski M, Carvalho M, Clermont A, Bursell SE, Song QH, Lem J, Duker JS, Schuman JS, Fujimoto JG. Noninvasive volumetric imaging and morphometry of the rodent retina with high-speed, ultrahigh-resolution optical coherence tomography. Invest Ophthalmol Vis Sci. 2006 Dec; 47(12):5522-8. PMID: 17122144; PMCID: PMC1941766.
  21. Ohshiro Y, Ma RC, Yasuda Y, Hiraoka-Yamamoto J, Clermont AC, Isshiki K, Yagi K, Arikawa E, Kern TS, King GL. Reduction of diabetes-induced oxidative stress, fibrotic cytokine expression, and renal dysfunction in protein kinase Cbeta-null mice. Diabetes. 2006 Nov; 55(11):3112-20. PMID: 17065350.
    View in: PubMed
  22. Yamagata M, Rook SL, Sassa Y, Ma RC, Geraldes P, Goddard L, Clermont A, Gao B, Salti H, Gundel R, White M, Feener EP, Aiello LP, King GL. Bactericidal/permeability-increasing protein's signaling pathways and its retinal trophic and anti-angiogenic effects. FASEB J. 2006 Oct; 20(12):2058-67. PMID: 17012258.
    View in: PubMed
  23. Clermont AC, Cahill M, Salti H, Rook SL, Rask-Madsen C, Goddard L, Wong JS, Bursell D, Bursell SE, Aiello LP. Hepatocyte growth factor induces retinal vascular permeability via MAP-kinase and PI-3 kinase without altering retinal hemodynamics. Invest Ophthalmol Vis Sci. 2006 Jun; 47(6):2701-8. PMID: 16723489.
    View in: PubMed
  24. Sotiropoulos KB, Clermont A, Yasuda Y, Rask-Madsen C, Mastumoto M, Takahashi J, Della Vecchia K, Kondo T, Aiello LP, King GL. Adipose-specific effect of rosiglitazone on vascular permeability and protein kinase C activation: novel mechanism for PPARgamma agonist's effects on edema and weight gain. FASEB J. 2006 Jun; 20(8):1203-5. PMID: 16672634.
    View in: PubMed
  25. Naruse K, Rask-Madsen C, Takahara N, Ha SW, Suzuma K, Way KJ, Jacobs JR, Clermont AC, Ueki K, Ohshiro Y, Zhang J, Goldfine AB, King GL. Activation of vascular protein kinase C-beta inhibits Akt-dependent endothelial nitric oxide synthase function in obesity-associated insulin resistance. Diabetes. 2006 Mar; 55(3):691-8. PMID: 16505232.
    View in: PubMed
  26. Clermont A, Bursell SE, Feener EP. Role of the angiotensin II type 1 receptor in the pathogenesis of diabetic retinopathy: effects of blood pressure control and beyond. J Hypertens Suppl. 2006 Mar; 24(1):S73-80. PMID: 16601577.
    View in: PubMed
  27. Aiello LP, Clermont A, Arora V, Davis MD, Sheetz MJ, Bursell SE. Inhibition of PKC beta by oral administration of ruboxistaurin is well tolerated and ameliorates diabetes-induced retinal hemodynamic abnormalities in patients. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):86-92. PMID: 16384948.
    View in: PubMed
  28. He Z, Way KJ, Arikawa E, Chou E, Opland DM, Clermont A, Isshiki K, Ma RC, Scott JA, Schoen FJ, Feener EP, King GL. Differential regulation of angiotensin II-induced expression of connective tissue growth factor by protein kinase C isoforms in the myocardium. J Biol Chem. 2005 Apr 22; 280(16):15719-26. PMID: 15699040.
    View in: PubMed
  29. Horio N, Clermont AC, Abiko A, Abiko T, Shoelson BD, Bursell SE, Feener EP. Angiotensin AT(1) receptor antagonism normalizes retinal blood flow and acetylcholine-induced vasodilatation in normotensive diabetic rats. Diabetologia. 2004 Jan; 47(1):113-23. PMID: 14618237.
    View in: PubMed
  30. Abiko T, Abiko A, Clermont AC, Shoelson B, Horio N, Takahashi J, Adamis AP, King GL, Bursell SE. Characterization of retinal leukostasis and hemodynamics in insulin resistance and diabetes: role of oxidants and protein kinase-C activation. Diabetes. 2003 Mar; 52(3):829-37. PMID: 12606527.
    View in: PubMed
  31. Finn AV, Gold HK, Tang A, Weber DK, Wight TN, Clermont A, Virmani R, Kolodgie FD. A novel rat model of carotid artery stenting for the understanding of restenosis in metabolic diseases. J Vasc Res. 2002 Sep-Oct; 39(5):414-25. PMID: 12297704.
    View in: PubMed
  32. Chou E, Suzuma I, Way KJ, Opland D, Clermont AC, Naruse K, Suzuma K, Bowling NL, Vlahos CJ, Aiello LP, King GL. Decreased cardiac expression of vascular endothelial growth factor and its receptors in insulin-resistant and diabetic States: a possible explanation for impaired collateral formation in cardiac tissue. Circulation. 2002 Jan 22; 105(3):373-9. PMID: 11804995.
    View in: PubMed
  33. Meier M, King GL, Clermont A, Perez A, Hayashi M, Feener EP. Angiotensin AT(1) receptor stimulates heat shock protein 27 phosphorylation in vitro and in vivo. Hypertension. 2001 Dec 01; 38(6):1260-5. PMID: 11751700.
    View in: PubMed
  34. Bursell SE, Cavallerano JD, Cavallerano AA, Clermont AC, Birkmire-Peters D, Aiello LP, Aiello LM. Stereo nonmydriatic digital-video color retinal imaging compared with Early Treatment Diabetic Retinopathy Study seven standard field 35-mm stereo color photos for determining level of diabetic retinopathy. Ophthalmology. 2001 Mar; 108(3):572-85. PMID: 11237913.
    View in: PubMed
  35. Suzuma I, Hata Y, Clermont A, Pokras F, Rook SL, Suzuma K, Feener EP, Aiello LP. Cyclic stretch and hypertension induce retinal expression of vascular endothelial growth factor and vascular endothelial growth factor receptor-2: potential mechanisms for exacerbation of diabetic retinopathy by hypertension. Diabetes. 2001 Feb; 50(2):444-54. PMID: 11272159.
    View in: PubMed
  36. Mori F, King GL, Clermont AC, Bursell DK, Bursell SE. Endothelin-3 regulation of retinal hemodynamics in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 2000 Nov; 41(12):3955-62. PMID: 11053299.
    View in: PubMed
  37. Feng D, Bursell SE, Clermont AC, Lipinska I, Aiello LP, Laffel L, King GL, Tofler GH. von Willebrand factor and retinal circulation in early-stage retinopathy of type 1 diabetes. Diabetes Care. 2000 Nov; 23(11):1694-8. PMID: 11092294.
    View in: PubMed
  38. Chen HC, Bouchie JL, Perez AS, Clermont AC, Izumo S, Hampe J, Feener EP. Role of the angiotensin AT(1) receptor in rat aortic and cardiac PAI-1 gene expression. Arterioscler Thromb Vasc Biol. 2000 Oct; 20(10):2297-302. PMID: 11031218.
    View in: PubMed
  39. Hata Y, Clermont A, Yamauchi T, Pierce EA, Suzuma I, Kagokawa H, Yoshikawa H, Robinson GS, Ishibashi T, Hashimoto T, Umeda F, Bursell SE, Aiello LP. Retinal expression, regulation, and functional bioactivity of prostacyclin-stimulating factor. J Clin Invest. 2000 Aug; 106(4):541-50. PMID: 10953029; PMCID: PMC380244.
  40. Miyamoto K, Khosrof S, Bursell SE, Rohan R, Murata T, Clermont AC, Aiello LP, Ogura Y, Adamis AP. Prevention of leukostasis and vascular leakage in streptozotocin-induced diabetic retinopathy via intercellular adhesion molecule-1 inhibition. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10836-41. PMID: 10485912; PMCID: PMC17969.
  41. Bursell SE, Clermont AC, Aiello LP, Aiello LM, Schlossman DK, Feener EP, Laffel L, King GL. High-dose vitamin E supplementation normalizes retinal blood flow and creatinine clearance in patients with type 1 diabetes. Diabetes Care. 1999 Aug; 22(8):1245-51. PMID: 10480765.
    View in: PubMed
  42. Higashi S, Clermont AC, Dhir V, Bursell SE. Reversibility of retinal flow abnormalities is disease-duration dependent in diabetic rats. Diabetes. 1998 Apr; 47(4):653-9. PMID: 9568700.
    View in: PubMed
  43. Bursell SE, Takagi C, Clermont AC, Takagi H, Mori F, Ishii H, King GL. Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats. Invest Ophthalmol Vis Sci. 1997 Dec; 38(13):2711-20. PMID: 9418723.
    View in: PubMed
  44. Clermont AC, Aiello LP, Mori F, Aiello LM, Bursell SE. Vascular endothelial growth factor and severity of nonproliferative diabetic retinopathy mediate retinal hemodynamics in vivo: a potential role for vascular endothelial growth factor in the progression of nonproliferative diabetic retinopathy. Am J Ophthalmol. 1997 Oct; 124(4):433-46. PMID: 9323935.
    View in: PubMed
  45. Aiello LP, Bursell SE, Clermont A, Duh E, Ishii H, Takagi C, Mori F, Ciulla TA, Ways K, Jirousek M, Smith LE, King GL. Vascular endothelial growth factor-induced retinal permeability is mediated by protein kinase C in vivo and suppressed by an orally effective beta-isoform-selective inhibitor. Diabetes. 1997 Sep; 46(9):1473-80. PMID: 9287049.
    View in: PubMed
  46. Takagi C, Bursell SE, Lin YW, Takagi H, Duh E, Jiang Z, Clermont AC, King GL. Regulation of retinal hemodynamics in diabetic rats by increased expression and action of endothelin-1. Invest Ophthalmol Vis Sci. 1996 Nov; 37(12):2504-18. PMID: 8933767.
    View in: PubMed
  47. Takagi C, King GL, Takagi H, Lin YW, Clermont AC, Bursell SE. Endothelin-1 action via endothelin receptors is a primary mechanism modulating retinal circulatory response to hyperoxia. Invest Ophthalmol Vis Sci. 1996 Sep; 37(10):2099-109. PMID: 8814149.
    View in: PubMed
  48. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, Clermont A, Bursell SE, Kern TS, Ballas LM, Heath WF, Stramm LE, Feener EP, King GL. Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science. 1996 May 03; 272(5262):728-31. PMID: 8614835.
    View in: PubMed
  49. Bursell SE, Clermont AC, Kinsley BT, Simonson DC, Aiello LM, Wolpert HA. Retinal blood flow changes in patients with insulin-dependent diabetes mellitus and no diabetic retinopathy. Invest Ophthalmol Vis Sci. 1996 Apr; 37(5):886-97. PMID: 8603873.
    View in: PubMed
  50. Takagi C, King GL, Clermont AC, Cummins DR, Takagi H, Bursell SE. Reversal of abnormal retinal hemodynamics in diabetic rats by acarbose, an alpha-glucosidase inhibitor. Curr Eye Res. 1995 Sep; 14(9):741-9. PMID: 8529412.
    View in: PubMed
  51. Kunisaki M, Bursell SE, Clermont AC, Ishii H, Ballas LM, Jirousek MR, Umeda F, Nawata H, King GL. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. 1995 Aug; 269(2 Pt 1):E239-46. PMID: 7653541.
    View in: PubMed
  52. Bursell SE, Clermont AC, Oren B, King GL. The in vivo effect of endothelins on retinal circulation in nondiabetic and diabetic rats. Invest Ophthalmol Vis Sci. 1995 Mar; 36(3):596-607. PMID: 7890491.
    View in: PubMed
  53. Clermont AC, Brittis M, Shiba T, McGovern T, King GL, Bursell SE. Normalization of retinal blood flow in diabetic rats with primary intervention using insulin pumps. Invest Ophthalmol Vis Sci. 1994 Mar; 35(3):981-90. PMID: 8125761.
    View in: PubMed
  54. Halvorsen YD, Bursell SE, Wilkison WO, Clermont AC, Brittis M, McGovern TJ, Spiegelman BM. Vasodilation of rat retinal microvessels induced by monobutyrin. Dysregulation in diabetes. J Clin Invest. 1993 Dec; 92(6):2872-6. PMID: 8254042; PMCID: PMC288489.
  55. Bursell SE, Clermont AC, Shiba T, King GL. Evaluating retinal circulation using video fluorescein angiography in control and diabetic rats. Curr Eye Res. 1992 Apr; 11(4):287-95. PMID: 1388117.
    View in: PubMed
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