Harvard Catalyst Profiles

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Gregory Michael Cote, M.D.


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Ingham M, Lee S, Van Tine BA, Choy E, Oza J, Doshi S, Ge L, Oppelt P, Cote G, Corgiat B, Sender N, Sta Ana S, Panchalingam L, Petricoin E, Schwartz GK. A single-arm phase 2 trial of Sitravatinib in advanced well-differentiated/dedifferentiated liposarcoma. Clin Cancer Res. 2022 Dec 22. PMID: 36548343.
    Citations:    Fields:    
  2. Dias-Santagata D, Heist RS, Bard AZ, da Silva AFL, Dagogo-Jack I, Nardi V, Ritterhouse LL, Spring LM, Jessop N, Farahani AA, Mino-Kenudson M, Allen J, Goyal L, Parikh A, Misdraji J, Shankar G, Jordan JT, Martinez-Lage M, Frosch M, Graubert T, Fathi AT, Hobbs GS, Hasserjian RP, Raje N, Abramson J, Schwartz JH, Sullivan RJ, Miller D, Hoang MP, Isakoff S, Ly A, Bouberhan S, Watkins J, Oliva E, Wirth L, Sadow PM, Faquin W, Cote GM, Hung YP, Gao X, Wu CL, Garg S, Rivera M, Le LP, John Iafrate A, Juric D, Hochberg EP, Clark J, Bardia A, Lennerz JK. Implementation and Clinical Adoption of Precision Oncology Workflows Across a Healthcare Network. Oncologist. 2022 11 03; 27(11):930-939. PMID: 35852437; PMCID: PMC9632318.
    Citations:    Fields:    
  3. Lozano-Calderón SA, Albergo JI, Groot OQ, Merchan NA, El Abiad JM, Salinas V, Gomez Mier LC, Montoya CS, Ferrone ML, Ready JE, Linares FJ, Levin AS, Peleteiro Pensado M, Pozo Kreilinger JJ, Ruiz IB, Ortiz-Cruz EJ, Gebhardt MC, Cote GM, Choy E, Spentzos D, Hung YP, Deshpande V, Chebib IA, McCulloch RA, Farfalli G, Aponte Tinao L, Morris CD, Petur Nielsen G, Anderson ME, Jeys LM. Complete tumor necrosis after neoadjuvant chemotherapy defines good responders in patients with Ewing sarcoma. Cancer. 2023 Jan 01; 129(1):60-70. PMID: 36305090.
    Citations:    Fields:    Translation:Humans
  4. Larque AB, Lozano-Calderon S, Cote GM, Chen YL, Hung YP, Deshpande V, Nielsen GP, Chebib I. Multivariate evaluation of prognostic markers in synovial sarcoma. J Clin Pathol. 2022 Oct 26. PMID: 36288948.
    Citations:    Fields:    
  5. Choy E, Cote GM, Michaelson MD, Wirth L, Gainor JF, Muzikansky A, Sequist LV, Sullivan RJ, Fidias PM, Shaw A, Heist RS. Phase II Study of Cabozantinib in Patients With Bone Metastasis. Oncologist. 2022 07 05; 27(7):600-606. PMID: 35524758; PMCID: PMC9256024.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  6. Möller E, Praz V, Rajendran S, Dong R, Cauderay A, Xing YH, Lee L, Fusco C, Broye LC, Cironi L, Iyer S, Rengarajan S, Awad ME, Naigles B, Letovanec I, Ormas N, Finzi G, La Rosa S, Sessa F, Chebib I, Petur Nielsen G, Digklia A, Spentzos D, Cote GM, Choy E, Aryee M, Stamenkovic I, Boulay G, Rivera MN, Riggi N. EWSR1-ATF1 dependent 3D connectivity regulates oncogenic and differentiation programs in Clear Cell Sarcoma. Nat Commun. 2022 04 27; 13(1):2267. PMID: 35477713; PMCID: PMC9046276.
    Citations:    Fields:    Translation:HumansCells
  7. Banfield W, Ioakeim-Ioannidou M, Goldberg S, Ahmed S, Schwab JH, Cote GM, Choy E, Shin JH, Hornicek FJ, Liebsch NJ, Chen YE, MacDonald SM, DeLaney TF. Definitive high-dose, proton-based radiation for unresected mobile spine and sacral chordomas. Radiother Oncol. 2022 06; 171:139-145. PMID: 35429502.
    Citations:    Fields:    Translation:Humans
  8. Georgantzoglou N, Aghighi M, Cote G, Hung YP, Kerr DA, Pettus J, Linos K. Primary Spindle Cell Sarcoma of the Lung with MGA::NUTM1 Fusion: An Extremely Rare Case of a Potentially Emerging Entity and Review of the Literature. Int J Surg Pathol. 2022 Dec; 30(8):931-938. PMID: 35388715.
    Citations:    Fields:    
  9. Lietz CE, Newman ET, Kelly AD, Xiang DH, Zhang Z, Luscko CA, Lozano-Calderon SA, Ebb DH, Raskin KA, Cote GM, Choy E, Nielsen GP, Haibe-Kains B, Aryee MJ, Spentzos D. Genome-wide DNA methylation patterns reveal clinically relevant predictive and prognostic subtypes in human osteosarcoma. Commun Biol. 2022 03 08; 5(1):213. PMID: 35260776; PMCID: PMC8904843.
    Citations: 1     Translation:HumansCells
  10. Tap WD, Singh AS, Anthony SP, Sterba M, Zhang C, Healey JH, Chmielowski B, Cohn AL, Shapiro GI, Keedy VL, Wainberg ZA, Puzanov I, Cote GM, Wagner AJ, Braiteh F, Sherman E, Hsu HH, Peterfy C, Gelhorn HL, Ye X, Severson P, West BL, Lin PS, Tong-Starksen S. Results from Phase I Extension Study Assessing Pexidartinib Treatment in Six Cohorts with Solid Tumors including TGCT, and Abnormal CSF1 Transcripts in TGCT. Clin Cancer Res. 2022 01 15; 28(2):298-307. PMID: 34716196; PMCID: PMC9401544.
    Citations:    Fields:    Translation:Humans
  11. Lessing AJ, Cote GM, DeLaney TF, Plotkin SR, Raskin KA, Lessing JN. Pseudoprogression of Malignant Peripheral Nerve Sheath Tumor in Patient with Neurofibromatosis Type 1, a Case Report. Case Rep Oncol. 2021 Sep-Dec; 14(3):1342-1346. PMID: 34720939; PMCID: PMC8525267.
  12. Chebib I, Taylor MS, Nardi V, Rivera MN, Lennerz JK, Cote GM, Choy E, Lozano Calderón SA, Raskin KA, Schwab JH, Mullen JT, Chen YE, Hung YP, Nielsen GP, Deshpande V. Clinical Utility of Anchored Multiplex Solid Fusion Assay for Diagnosis of Bone and Soft Tissue Tumors. Am J Surg Pathol. 2021 08 01; 45(8):1127-1137. PMID: 34115673.
    Citations:    Fields:    Translation:Humans
  13. Wedekind MF, Widemann BC, Cote G. Chordoma: Current status, problems, and future directions. Curr Probl Cancer. 2021 08; 45(4):100771. PMID: 34266694.
    Citations: 1     Fields:    Translation:Humans
  14. Mellinghoff IK, Penas-Prado M, Peters KB, Burris HA, Maher EA, Janku F, Cote GM, de la Fuente MI, Clarke JL, Ellingson BM, Chun S, Young RJ, Liu H, Choe S, Lu M, Le K, Hassan I, Steelman L, Pandya SS, Cloughesy TF, Wen PY. Vorasidenib, a Dual Inhibitor of Mutant IDH1/2, in Recurrent or Progressive Glioma; Results of a First-in-Human Phase I Trial. Clin Cancer Res. 2021 08 15; 27(16):4491-4499. PMID: 34078652; PMCID: PMC8364866.
    Citations: 16     Fields:    Translation:HumansCTClinical Trials
  15. Messallam AA, Adler DG, Shah RJ, Nieto JM, Moran R, Elmunzer BJ, Cosgrove N, Mullady D, Singh H, Cote G, Papachristou GI, Othman MO, Zhang C, Javaid H, Mercado M, Tsistrakis S, Kumta NA, Nagula S, Dimaio CJ, Birch MS, Taylor LJ, Labarre N, Han S, Hollander T, Keilin SA, Cai Q, Willingham FF. Direct Endoscopic Necrosectomy With and Without Hydrogen Peroxide for Walled-off Pancreatic Necrosis: A Multicenter Comparative Study. Am J Gastroenterol. 2021 04; 116(4):700-709. PMID: 33982939.
    Citations: 1     Fields:    Translation:Humans
  16. Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C, Cohen O, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D, Gritsch S, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G, Chebib I, Nguyen-Ngoc T, Montemurro M, Cote GM, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Wucherpfennig KW, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A. Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma. Nat Med. 2021 02; 27(2):289-300. PMID: 33495604; PMCID: PMC8817899.
    Citations: 16     Fields:    Translation:HumansCells
  17. Boulay G, Cironi L, Garcia SP, Rengarajan S, Xing YH, Lee L, Awad ME, Naigles B, Iyer S, Broye LC, Keskin T, Cauderay A, Fusco C, Letovanec I, Chebib I, Nielsen PG, Tercier S, Cherix S, Nguyen-Ngoc T, Cote G, Choy E, Provero P, Suvà ML, Rivera MN, Stamenkovic I, Riggi N. The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies. Life Sci Alliance. 2021 02; 4(2). PMID: 33361335.
    Citations: 3     Fields:    Translation:HumansCells
  18. Berezhnoy A, Sumrow BJ, Stahl K, Shah K, Liu D, Li J, Hao SS, De Costa A, Kaul S, Bendell J, Cote GM, Luke JJ, Sanborn RE, Sharma MR, Chen F, Li H, Diedrich G, Bonvini E, Moore PA. Development and Preliminary Clinical Activity of PD-1-Guided CTLA-4 Blocking Bispecific DART Molecule. Cell Rep Med. 2020 12 22; 1(9):100163. PMID: 33377134; PMCID: PMC7762776.
    Citations: 6     Fields:    Translation:HumansCells
  19. Gounder M, Schöffski P, Jones RL, Agulnik M, Cote GM, Villalobos VM, Attia S, Chugh R, Chen TW, Jahan T, Loggers ET, Gupta A, Italiano A, Demetri GD, Ratan R, Davis LE, Mir O, Dileo P, Van Tine BA, Pressey JG, Lingaraj T, Rajarethinam A, Sierra L, Agarwal S, Stacchiotti S. Tazemetostat in advanced epithelioid sarcoma with loss of INI1/SMARCB1: an international, open-label, phase 2 basket study. Lancet Oncol. 2020 11; 21(11):1423-1432. PMID: 33035459.
    Citations: 53     Fields:    Translation:HumansCTClinical Trials
  20. Li X, Dean DC, Cote GM, Zou L, Hornicek FJ, Yu S, Duan Z. Inhibition of ATR-Chk1 signaling blocks DNA double-strand-break repair and induces cytoplasmic vacuolization in metastatic osteosarcoma. Ther Adv Med Oncol. 2020; 12:1758835920956900. PMID: 32973933; PMCID: PMC7493280.
    Citations: 4     
  21. Hung YP, Diaz-Perez JA, Cote GM, Wejde J, Schwab JH, Nardi V, Chebib IA, Deshpande V, Selig MK, Bredella MA, Rosenberg AE, Nielsen GP. Dedifferentiated Chordoma: Clinicopathologic and Molecular Characteristics With Integrative Analysis. Am J Surg Pathol. 2020 09; 44(9):1213-1223. PMID: 32427623.
    Citations: 4     Fields:    Translation:Humans
  22. Mellinghoff IK, Ellingson BM, Touat M, Maher E, De La Fuente MI, Holdhoff M, Cote GM, Burris H, Janku F, Young RJ, Huang R, Jiang L, Choe S, Fan B, Yen K, Lu M, Bowden C, Steelman L, Pandya SS, Cloughesy TF, Wen PY. Ivosidenib in Isocitrate Dehydrogenase 1-Mutated Advanced Glioma. J Clin Oncol. 2020 10 10; 38(29):3398-3406. PMID: 32530764.
    Citations: 46     Fields:    Translation:HumansCTClinical Trials
  23. Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma. Cell Rep. 2020 Apr 14; 31(2):107539. PMID: 32294441.
    Citations:    Fields:    
  24. Keskin T, Bakaric A, Waszyk P, Boulay G, Torsello M, Cornaz-Buros S, Chevalier N, Geiser T, Martin P, Volorio A, Iyer S, Kulkarni A, Letovanec I, Cherix S, Cote GM, Choy E, Digklia A, Montemurro M, Chebib I, Nielsen PG, Carcaboso AM, Mora J, Renella R, Suvà ML, Fusco C, Provero P, Rivera MN, Riggi N, Stamenkovic I. LIN28B Underlies the Pathogenesis of a Subclass of Ewing Sarcoma LIN28B Control of EWS-FLI1 Stability. Cell Rep. 2020 03 31; 30(13):4567-4583.e5. PMID: 32234488.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Tap WD, Villalobos VM, Cote GM, Burris H, Janku F, Mir O, Beeram M, Wagner AJ, Jiang L, Wu B, Choe S, Yen K, Gliser C, Fan B, Agresta S, Pandya SS, Trent JC. Phase I Study of the Mutant IDH1 Inhibitor Ivosidenib: Safety and Clinical Activity in Patients With Advanced Chondrosarcoma. J Clin Oncol. 2020 05 20; 38(15):1693-1701. PMID: 32208957.
    Citations: 27     Fields:    Translation:HumansCTClinical Trials
  26. Lietz CE, Garbutt C, Barry WT, Deshpande V, Chen YL, Lozano-Calderon SA, Wang Y, Lawney B, Ebb D, Cote GM, Duan Z, Hornicek FJ, Choy E, Petur Nielsen G, Haibe-Kains B, Quackenbush J, Spentzos D. MicroRNA-mRNA networks define translatable molecular outcome phenotypes in osteosarcoma. Sci Rep. 2020 03 10; 10(1):4409. PMID: 32157112; PMCID: PMC7064533.
    Citations: 4     Fields:    Translation:Humans
  27. Cote GM, Choy E, Chen T, Marino-Enriquez A, Morgan J, Merriam P, Thornton K, Wagner AJ, Nathenson MJ, Demetri G, George S. A phase II multi-strata study of lurbinectedin as a single agent or in combination with conventional chemotherapy in metastatic and/or unresectable sarcomas. Eur J Cancer. 2020 02; 126:21-32. PMID: 31896519.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  28. Miao R, Choy E, Raskin KA, Schwab JH, Nielsen GP, Deshpande V, Chebib I, DeLaney TF, Hornicek FJ, Cote GM, Chen YE. Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution. Sarcoma. 2019; 2019:9069272. PMID: 31915413; PMCID: PMC6930709.
    Citations: 6     
  29. Saag M, Mendoza DP, Sherman MS, Cote GM, Shih AR. Case 36-2019: A 34-Year-Old Man with Dyspnea, Odynophagia, and Abdominal Pain. N Engl J Med. 2019 11 21; 381(21):2052-2061. PMID: 31747731.
    Citations:    Fields:    Translation:Humans
  30. Lozano Calderón SA, Garbutt C, Kim J, Lietz CE, Chen YL, Bernstein K, Chebib I, Nielsen GP, Deshpande V, Rubio R, Wang YE, Quackenbush J, Delaney T, Raskin K, Schwab J, Cote G, Spentzos D. Clinical and Molecular Analysis of Pathologic Fracture-associated Osteosarcoma: MicroRNA profile Is Different and Correlates with Prognosis. Clin Orthop Relat Res. 2019 Sep; 477(9):2114-2126. PMID: 31389890; PMCID: PMC7000091.
    Citations: 7     Fields:    Translation:Humans
  31. Widemann BC, Lu Y, Reinke D, Okuno SH, Meyer CF, Cote GM, Chugh R, Milhem MM, Hirbe AC, Kim A, Turpin B, Pressey JG, Dombi E, Jayaprakash N, Helman LJ, Onwudiwe N, Cichowski K, Perentesis JP. Targeting Sporadic and Neurofibromatosis Type 1 (NF1) Related Refractory Malignant Peripheral Nerve Sheath Tumors (MPNST) in a Phase II Study of Everolimus in Combination with Bevacizumab (SARC016). Sarcoma. 2019; 2019:7656747. PMID: 31427883; PMCID: PMC6681622.
    Citations: 20     
  32. Miao R, Wang H, Jacobson A, Lietz AP, Choy E, Raskin KA, Schwab JH, Deshpande V, Nielsen GP, DeLaney TF, Cote GM, Hornicek FJ, Chen YE. Radiation-induced and neurofibromatosis-associated malignant peripheral nerve sheath tumors (MPNST) have worse outcomes than sporadic MPNST. Radiother Oncol. 2019 08; 137:61-70. PMID: 31078939.
    Citations: 17     Fields:    Translation:Humans
  33. Chougule A, Taylor MS, Nardi V, Chebib I, Cote GM, Choy E, Nielsen GP, Deshpande V. Spindle and Round Cell Sarcoma With EWSR1-PATZ1 Gene Fusion: A Sarcoma With Polyphenotypic Differentiation. Am J Surg Pathol. 2019 02; 43(2):220-228. PMID: 30379650; PMCID: PMC6590674.
    Citations: 15     Fields:    Translation:Humans
  34. Chowdhry V, Goldberg S, DeLaney TF, Cote GM, Chebib I, Kim J, Lozano-Calderón SA, De Amorim Bernstein K. Myxoid Liposarcoma: Treatment Outcomes from Chemotherapy and Radiation Therapy. Sarcoma. 2018; 2018:8029157. PMID: 30515050; PMCID: PMC6236966.
    Citations: 12     
  35. Sanford NN, Miao R, Wang H, Goldberg S, Jacobson A, Brunner AM, Cote GM, Yock TI, Ebb DH, Chen YB, Jee KW, Hornicek F, DeLaney TF, Choy E, Chen YL. Characteristics and Predictors for Secondary Leukemia and Myelodysplastic Syndrome in Ewing and Osteosarcoma Survivors. Int J Radiat Oncol Biol Phys. 2019 01 01; 103(1):52-61. PMID: 30165126.
    Citations: 1     Fields:    Translation:Humans
  36. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Author Correction: Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2018 Aug 09; 8(1):12107. PMID: 30093700.
    Citations:    Fields:    
  37. Cote GM, Barysauskas CM, DeLaney TF, Schwab J, Raskin K, Lozano-Calderon S, Bernstein K, Mullen JT, Haynes AB, Hornicek F, Chen YE, Choy E. A Phase 1 Study of Nilotinib Plus Radiation in High-Risk Chordoma. Int J Radiat Oncol Biol Phys. 2018 12 01; 102(5):1496-1504. PMID: 30077789.
    Citations: 5     Fields:    Translation:HumansCTClinical Trials
  38. Tolcher A, Flaherty K, Shapiro GI, Berlin J, Witzig T, Habermann T, Bullock A, Rock E, Elekes A, Lin C, Kostic D, Ohi N, Rasco D, Papadopoulos KP, Patnaik A, Smith L, Cote GM. A First-in-Human Phase I Study of OPB-111077, a Small-Molecule STAT3 and Oxidative Phosphorylation Inhibitor, in Patients with Advanced Cancers. Oncologist. 2018 06; 23(6):658-e72. PMID: 29511132.
    Citations: 22     Fields:    Translation:HumansCTClinical Trials
  39. Shih AR, Cote GM, Chebib I, Choy E, DeLaney T, Deshpande V, Hornicek FJ, Miao R, Schwab JH, Nielsen GP, Chen YL. Clinicopathologic characteristics of poorly differentiated chordoma. Mod Pathol. 2018 08; 31(8):1237-1245. PMID: 29483606.
    Citations: 28     Fields:    Translation:Humans
  40. Schaefer IM, Cote GM, Hornick JL. Contemporary Sarcoma Diagnosis, Genetics, and Genomics. J Clin Oncol. 2018 01 10; 36(2):101-110. PMID: 29220288.
    Citations: 32     Fields:    Translation:Humans
  41. Sanford NN, Martin AM, Brunner AM, Cote GM, Choy E, DeLaney TF, Aizer AA, Chen YL. Secondary Acute Leukemia in Sarcoma Patients: A Population-Based Study. Int J Radiat Oncol Biol Phys. 2018 03 01; 100(3):687-694. PMID: 29413281.
    Citations: 1     Fields:    Translation:Humans
  42. Wander SA, Hasserjian RP, Oduro K, Glomski K, Nardi V, Cote GM, Graubert TA, Brunner AM, Chen YA, Fathi AT. Combined Targeted Therapy for BRAF-Mutant, Treatment-Related Acute Myeloid Leukemia. JCO Precis Oncol. 2017 Nov; 1:1-7. PMID: 35172484.
    Citations:    Fields:    
  43. Cote GM, He J, Choy E. Next-Generation Sequencing for Patients with Sarcoma: A Single Center Experience. Oncologist. 2018 02; 23(2):234-242. PMID: 28860410.
    Citations: 19     Fields:    Translation:Humans
  44. Duell EJ, Lujan-Barroso L, Sala N, Deitz McElyea S, Overvad K, Tjonneland A, Olsen A, Weiderpass E, Busund LT, Moi L, Muller D, Vineis P, Aune D, Matullo G, Naccarati A, Panico S, Tagliabue G, Tumino R, Palli D, Kaaks R, Katzke VA, Boeing H, Bueno-de-Mesquita HBA, Peeters PH, Trichopoulou A, Lagiou P, Kotanidou A, Travis RC, Wareham N, Khaw KT, Ramon Quiros J, Rodríguez-Barranco M, Dorronsoro M, Chirlaque MD, Ardanaz E, Severi G, Boutron-Ruault MC, Rebours V, Brennan P, Gunter M, Scelo G, Cote G, Sherman S, Korc M. Plasma microRNAs as biomarkers of pancreatic cancer risk in a prospective cohort study. Int J Cancer. 2017 09 01; 141(5):905-915. PMID: 28542740.
    Citations: 27     Fields:    Translation:Humans
  45. Hill KE, Kelly AD, Kuijjer ML, Barry W, Rattani A, Garbutt CC, Kissick H, Janeway K, Perez-Atayde A, Goldsmith J, Gebhardt MC, Arredouani MS, Cote G, Hornicek F, Choy E, Duan Z, Quackenbush J, Haibe-Kains B, Spentzos D. An imprinted non-coding genomic cluster at 14q32 defines clinically relevant molecular subtypes in osteosarcoma across multiple independent datasets. J Hematol Oncol. 2017 05 15; 10(1):107. PMID: 28506242.
    Citations: 15     Fields:    Translation:HumansCells
  46. Liao Y, Chen L, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Targeting programmed cell death ligand 1 by CRISPR/Cas9 in osteosarcoma cells. Oncotarget. 2017 May 02; 8(18):30276-30287. PMID: 28415820.
    Citations: 30     Fields:    Translation:HumansCells
  47. Liao Y, Sassi S, Halvorsen S, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Androgen receptor is a potential novel prognostic marker and oncogenic target in osteosarcoma with dependence on CDK11. Sci Rep. 2017 03 06; 7:43941. PMID: 28262798.
    Citations: 4     Fields:    Translation:HumansCells
  48. De Amorim Bernstein K, Liebsch N, Chen YL, Niemierko A, Schwab JH, Raskin K, Lozano-Calderon SA, Cote G, Harmon DC, Choy E, Haynes A, Mullen J, Hornicek FJ, DeLaney TF. Clinical outcomes for patients after surgery and radiation therapy for mesenchymal chondrosarcomas. J Surg Oncol. 2016 Dec; 114(8):982-986. PMID: 27790706.
    Citations: 6     Fields:    Translation:Humans
  49. Duan Z, Gao Y, Shen J, Choy E, Cote G, Harmon D, Bernstein K, Lozano-Calderon S, Mankin H, Hornicek FJ. miR-15b modulates multidrug resistance in human osteosarcoma in vitro and in vivo. Mol Oncol. 2017 02; 11(2):151-166. PMID: 28145098.
    Citations: 23     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
  50. Molina G, Hull MA, Chen YL, DeLaney TF, De Amorim Bernstein K, Choy E, Cote G, Harmon DC, Mullen JT, Haynes AB. Preoperative radiation therapy combined with radical surgical resection is associated with a lower rate of local recurrence when treating unifocal, primary retroperitoneal liposarcoma. J Surg Oncol. 2016 Dec; 114(7):814-820. PMID: 27634478.
    Citations: 9     Fields:    Translation:Humans
  51. Ahmad R, Jacobson A, Hornicek F, Haynes AB, Choy E, Cote G, Nielsen GP, Chen YL, DeLaney TF, Mullen JT. The Width of the Surgical Margin Does Not Influence Outcomes in Extremity and Truncal Soft Tissue Sarcoma Treated With Radiotherapy. Oncologist. 2016 10; 21(10):1269-1276. PMID: 27440063.
    Citations: 11     Fields:    Translation:Humans
  52. Shen JK, Cote GM, Gao Y, Choy E, Mankin HJ, Hornicek FJ, Duan Z. Targeting EZH2-mediated methylation of H3K27 inhibits proliferation and migration of Synovial Sarcoma in vitro. Sci Rep. 2016 04 29; 6:25239. PMID: 27125524.
    Citations: 23     Fields:    Translation:HumansCells
  53. Gao Y, Liao Y, Shen JK, Feng Y, Choy E, Cote G, Harmon D, Mankin HJ, Hornicek FJ, Duan Z. Evaluation of P-glycoprotein (Pgp) expression in human osteosarcoma by high-throughput tissue microarray. J Orthop Res. 2016 09; 34(9):1606-12. PMID: 26790551.
    Citations: 8     Fields:    Translation:Humans
  54. Ye S, Zhang J, Shen J, Gao Y, Li Y, Choy E, Cote G, Harmon D, Mankin H, Gray NS, Hornicek FJ, Duan Z. NVP-TAE684 reverses multidrug resistance (MDR) in human osteosarcoma by inhibiting P-glycoprotein (PGP1) function. Br J Pharmacol. 2016 Feb; 173(3):613-26. PMID: 26603906.
    Citations: 14     Fields:    Translation:HumansCells
  55. Liao Y, Feng Y, Shen J, Gao Y, Cote G, Choy E, Harmon D, Mankin H, Hornicek F, Duan Z. Clinical and biological significance of PIM1 kinase in osteosarcoma. J Orthop Res. 2016 07; 34(7):1185-94. PMID: 26687194.
    Citations: 11     Fields:    Translation:HumansCells
  56. Cote GM. Rank ligand as a target in musculoskeletal neoplasms. Curr Rev Musculoskelet Med. 2015 Dec; 8(4):339-43. PMID: 26452557; PMCID: PMC4630234.
    Citations: 2     
  57. Gao Y, Feng Y, Shen JK, Lin M, Choy E, Cote GM, Harmon DC, Mankin HJ, Hornicek FJ, Duan Z. CD44 is a direct target of miR-199a-3p and contributes to aggressive progression in osteosarcoma. Sci Rep. 2015 Jun 16; 5:11365. PMID: 26079799.
    Citations: 39     Fields:    Translation:HumansCells
  58. Feng Y, Shen J, Gao Y, Liao Y, Cote G, Choy E, Chebib I, Mankin H, Hornicek F, Duan Z. Expression of programmed cell death ligand 1 (PD-L1) and prevalence of tumor-infiltrating lymphocytes (TILs) in chordoma. Oncotarget. 2015 May 10; 6(13):11139-49. PMID: 25871477; PMCID: PMC4484445.
    Citations: 42     Fields:    Translation:HumansCells
  59. Yang X, Feng Y, Gao Y, Shen J, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z. NSC23925 prevents the emergence of multidrug resistance in ovarian cancer in vitro and in vivo. Gynecol Oncol. 2015 Apr; 137(1):134-42. PMID: 25677062.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  60. Choy E, Flamand Y, Balasubramanian S, Butrynski JE, Harmon DC, George S, Cote GM, Wagner AJ, Morgan JA, Sirisawad M, Mani C, Hornicek FJ, Duan Z, Demetri GD. Phase 1 study of oral abexinostat, a histone deacetylase inhibitor, in combination with doxorubicin in patients with metastatic sarcoma. Cancer. 2015 Apr 15; 121(8):1223-30. PMID: 25536954; PMCID: PMC4393337.
    Citations: 21     Fields:    Translation:HumansCTClinical Trials
  61. Choy E, Butrynski JE, Harmon DC, Morgan JA, George S, Wagner AJ, D'Adamo D, Cote GM, Flamand Y, Benes CH, Haber DA, Baselga JM, Demetri GD. Phase II study of olaparib in patients with refractory Ewing sarcoma following failure of standard chemotherapy. BMC Cancer. 2014 Nov 05; 14:813. PMID: 25374341; PMCID: PMC4230717.
    Citations: 63     Fields:    Translation:HumansCTClinical Trials
  62. Duan Z, Zhang J, Ye S, Shen J, Choy E, Cote G, Harmon D, Mankin H, Hua Y, Zhang Y, Gray NS, Hornicek FJ. A-770041 reverses paclitaxel and doxorubicin resistance in osteosarcoma cells. BMC Cancer. 2014 Sep 19; 14:681. PMID: 25236161.
    Citations: 8     Fields:    Translation:HumansCells
  63. Jacobsen E, Pozdnyakova O, Redd R, Fisher DC, Dorfman DM, Dal Cin P, LaCasce A, Armand P, Hochberg E, Cote G, Shahsafaei A, Neuberg D, Brown JR, Freedman AS. Imatinib mesylate lacks efficacy in relapsed/refractory peripheral T cell lymphoma. Leuk Lymphoma. 2015 Apr; 56(4):993-8. PMID: 25012943.
    Citations: 1     Fields:    Translation:HumansCTClinical Trials
  64. Shen JK, Cote GM, Choy E, Hornicek FJ, Duan Z. Targeting programmed cell death ligand 1 in osteosarcoma: an auto-commentary on therapeutic potential. Oncoimmunology. 2014; 3(8):e954467. PMID: 25610746.
    Citations: 4     Fields:    
  65. Choy E, MacConaill LE, Cote GM, Le LP, Shen JK, Nielsen GP, Iafrate AJ, Garraway LA, Hornicek FJ, Duan Z. Genotyping cancer-associated genes in chordoma identifies mutations in oncogenes and areas of chromosomal loss involving CDKN2A, PTEN, and SMARCB1. PLoS One. 2014; 9(7):e101283. PMID: 24983247.
    Citations: 30     Fields:    Translation:Humans
  66. Yang X, Yang P, Shen J, Osaka E, Choy E, Cote G, Harmon D, Zhang Z, Mankin H, Hornicek FJ, Duan Z. Prevention of multidrug resistance (MDR) in osteosarcoma by NSC23925. Br J Cancer. 2014 Jun 10; 110(12):2896-904. PMID: 24853187.
    Citations: 21     Fields:    Translation:HumansCells
  67. Shen JK, Cote GM, Choy E, Yang P, Harmon D, Schwab J, Nielsen GP, Chebib I, Ferrone S, Wang X, Wang Y, Mankin H, Hornicek FJ, Duan Z. Programmed cell death ligand 1 expression in osteosarcoma. Cancer Immunol Res. 2014 Jul; 2(7):690-698. PMID: 24866169.
    Citations: 91     Fields:    Translation:HumansCells
  68. Guo S, Lopez-Marquez H, Fan KC, Choy E, Cote G, Harmon D, Nielsen GP, Yang C, Zhang C, Mankin H, Hornicek FJ, Borger DR, Duan Z. Synergistic effects of targeted PI3K signaling inhibition and chemotherapy in liposarcoma. PLoS One. 2014; 9(4):e93996. PMID: 24695632; PMCID: PMC3973642.
    Citations: 9     Fields:    Translation:HumansCells
  69. LeBlanc JK, Chen JH, Al-Haddad M, Juan M, Okumu W, McHenry L, Cote G, Sherman S, DeWitt JM. Endoscopic ultrasound and histology in chronic pancreatitis: how are they associated? Pancreas. 2014 Apr; 43(3):440-4. PMID: 24622076.
    Citations: 13     Fields:    Translation:Humans
  70. Duan Z, Shen J, Yang X, Yang P, Osaka E, Choy E, Cote G, Harmon D, Zhang Y, Nielsen GP, Spentzos D, Mankin H, Hornicek F. Prognostic significance of miRNA-1 (miR-1) expression in patients with chordoma. J Orthop Res. 2014 May; 32(5):695-701. PMID: 24501096.
    Citations: 19     Fields:    Translation:HumansCells
  71. El Chafic AH, Dewitt J, Leblanc JK, El Hajj II, Cote G, House MG, Sherman S, McHenry L, Pitt HA, Johnson C, Mohamadnejad M, Al-Haddad M. Impact of preoperative endoscopic ultrasound-guided fine needle aspiration on postoperative recurrence and survival in cholangiocarcinoma patients. Endoscopy. 2013 Nov; 45(11):883-9. PMID: 24165813.
    Citations: 27     Fields:    Translation:Humans
  72. Jia B, Choy E, Cote G, Harmon D, Ye S, Kan Q, Mankin H, Hornicek F, Duan Z. Cyclin-dependent kinase 11 (CDK11) is crucial in the growth of liposarcoma cells. Cancer Lett. 2014 Jan 01; 342(1):104-12. PMID: 24007862.
    Citations: 23     Fields:    Translation:HumansCells
  73. Cote GM, Choy E. Role of epigenetic modulation for the treatment of sarcoma. Curr Treat Options Oncol. 2013 Sep; 14(3):454-64. PMID: 23749746.
    Citations: 11     Fields:    Translation:Humans
  74. Cote GM, Choy E. Update in treatment and targets in Ewing sarcoma. Hematol Oncol Clin North Am. 2013 Oct; 27(5):1007-19. PMID: 24093173.
    Citations: 4     Fields:    Translation:Humans
  75. Cote GM, Sawyer DB, Chabner BA. ERBB2 inhibition and heart failure. N Engl J Med. 2013 02 28; 368(9):876. PMID: 23445109.
    Citations: 2     Fields:    Translation:HumansAnimals
  76. Cote GM, Sawyer DB, Chabner BA. ERBB2 inhibition and heart failure. N Engl J Med. 2012 Nov 29; 367(22):2150-3. PMID: 23190227.
    Citations: 35     Fields:    Translation:HumansAnimals
  77. Elmunzer BJ, Scheiman JM, Lehman GA, Chak A, Mosler P, Higgins PD, Hayward RA, Romagnuolo J, Elta GH, Sherman S, Waljee AK, Repaka A, Atkinson MR, Cote GA, Kwon RS, McHenry L, Piraka CR, Wamsteker EJ, Watkins JL, Korsnes SJ, Schmidt SE, Turner SM, Nicholson S, Fogel EL. A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis. N Engl J Med. 2012 Apr 12; 366(15):1414-22. PMID: 22494121; PMCID: PMC3339271.
    Citations: 175     Fields:    Translation:Humans
  78. Cote GM, Canellos GP. Can low-risk, early-stage patients with Hodgkin lymphoma be spared radiotherapy? Curr Hematol Malig Rep. 2011 Sep; 6(3):180-6. PMID: 21503634.
    Citations: 1     Fields:    Translation:Humans
  79. Molina JR, Agarwal NK, Morales FC, Hayashi Y, Aldape KD, Cote G, Georgescu MM. PTEN, NHERF1 and PHLPP form a tumor suppressor network that is disabled in glioblastoma. Oncogene. 2012 Mar 08; 31(10):1264-74. PMID: 21804599.
    Citations: 86     Fields:    Translation:HumansCells
  80. Cote GM, Hochberg EP, Muzikansky A, Hochberg FH, Drappatz J, McAfee SL, Batchelor TT, LaCasce AS, Fisher DC, Abramson JS, Armand P, Chen YB. Autologous stem cell transplantation with thiotepa, busulfan, and cyclophosphamide (TBC) conditioning in patients with CNS involvement by non-Hodgkin lymphoma. Biol Blood Marrow Transplant. 2012 Jan; 18(1):76-83. PMID: 21749848.
    Citations: 24     Fields:    Translation:Humans
  81. Pentassuglia L, Graf M, Lane H, Kuramochi Y, Cote G, Timolati F, Sawyer DB, Zuppinger C, Suter TM. Inhibition of ErbB2 by receptor tyrosine kinase inhibitors causes myofibrillar structural damage without cell death in adult rat cardiomyocytes. Exp Cell Res. 2009 Apr 15; 315(7):1302-12. PMID: 19331811.
    Citations: 24     Fields:    Translation:AnimalsCells
  82. Moondra V, Sarma S, Buxton T, Safa R, Cote G, Storer T, Lebrasseur NK, Sawyer DB. Serum Neuregulin-1beta as a Biomarker of Cardiovascular Fitness. Open Biomark J. 2009; 2:1-5. PMID: 20634924.
    Citations: 15     
  83. Miller TA, Icli B, Cote GM, Lebrasseur NK, Borkan SC, Pimentel DR, Peng X, Sawyer DB. Palmitate alters neuregulin signaling and biology in cardiac myocytes. Biochem Biophys Res Commun. 2009 Jan 30; 379(1):32-7. PMID: 19070592.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  84. Miller TA, LeBrasseur NK, Cote GM, Trucillo MP, Pimentel DR, Ido Y, Ruderman NB, Sawyer DB. Oleate prevents palmitate-induced cytotoxic stress in cardiac myocytes. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):309-15. PMID: 16126172.
    Citations: 53     Fields:    Translation:AnimalsCells
  85. Cote GM, Miller TA, Lebrasseur NK, Kuramochi Y, Sawyer DB. Neuregulin-1alpha and beta isoform expression in cardiac microvascular endothelial cells and function in cardiac myocytes in vitro. Exp Cell Res. 2005 Nov 15; 311(1):135-46. PMID: 16185687.
    Citations: 48     Fields:    Translation:AnimalsCells
  86. Kuramochi Y, Cote GM, Guo X, Lebrasseur NK, Cui L, Liao R, Sawyer DB. Cardiac endothelial cells regulate reactive oxygen species-induced cardiomyocyte apoptosis through neuregulin-1beta/erbB4 signaling. J Biol Chem. 2004 Dec 03; 279(49):51141-7. PMID: 15385548.
    Citations: 89     Fields:    Translation:HumansAnimalsCells
  87. Tanaka Y, Koido S, Xia J, Ohana M, Liu C, Cote GM, Sawyer DB, Calderwood S, Gong J. Development of antigen-specific CD8+ CTL in MHC class I-deficient mice through CD4 to CD8 conversion. J Immunol. 2004 Jun 15; 172(12):7848-58. PMID: 15187169.
    Citations: 9     Fields:    Translation:AnimalsCellsPHPublic Health
  88. Evans DB, Fleming JB, Lee JE, Cote G, Gagel RF. The surgical treatment of medullary thyroid carcinoma. Semin Surg Oncol. 1999 Jan-Feb; 16(1):50-63. PMID: 9890740.
    Citations: 7     Fields:    Translation:Humans
  89. Eng C, Clayton D, Schuffenecker I, Lenoir G, Cote G, Gagel RF, van Amstel HK, Lips CJ, Nishisho I, Takai SI, Marsh DJ, Robinson BG, Frank-Raue K, Raue F, Xue F, Noll WW, Romei C, Pacini F, Fink M, Niederle B, Zedenius J, Nordenskjöld M, Komminoth P, Hendy GN, Mulligan LM, et al. The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis. JAMA. 1996 Nov 20; 276(19):1575-9. PMID: 8918855.
    Citations: 239     Fields:    Translation:Humans
  90. Leaf A, Jorgensen MB, Jacobs AK, Cote G, Schoenfeld DA, Scheer J, Weiner BH, Slack JD, Kellett MA, Raizner AE, et al. Do fish oils prevent restenosis after coronary angioplasty? Circulation. 1994 Nov; 90(5):2248-57. PMID: 7955181.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.