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David T. Breault, Ph.D., M.D.

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Available: 03/17/22, Expires: 05/01/22

Diabetes mellitus is a worldwide, ever-growing epidemic. Even though there have been incredible advances in the management of diabetes in recent years, a more permanent treatment for diabetes mellitus has remained elusive. Using genetic techniques and directed differentiation with small molecules, the scientific community has managed to create beta cells from multiple stem cell types; however, important issues remain regarding their viability, host immune response, risk for neoplasia as well ethical concerns. By using a patient's own adult stem cells, one may be able to bypass these issues. Gastrointestinal (GI) stem cells are plentiful in mature gut, are easily accessible via endoscopy, and can be readily expanded and differentiated ex vivo into mature cell types, including enteroendocrine cells (EECs), which secrete incretin hormones that increase insulin release with food intake, in three-dimensional structures known as enteroids. Moreover, proof-of-principle studies in mice have shown that EE cells can be efficiently reprogrammed into insulin-secreting beta-like cells upon introduction of key beta cell transcription factors. Our preliminary studies show that human EE cells can be reprogrammed into insulin-expressing cells, albeit with reduced efficiency compared to the murine studies. This project seeks to examine the ability of GI stem cells to produce incretin-secreting and insulin-secreting cells through small molecules. We anticipate that this could provide a novel, personalized treatment strategy in diabetes mellitus that circumvents the host immune response and the need for direct genetic modification. A medical student involved in this project would have a large role, along with a post-doc, in screening small molecules for their role in increasing enteroendocrine differentiation and increasing beta cell specific targets. This will involve in vitro culturing of human enteroids, isolating RNA and performing qualitative, real-time PCR, and examining protein expression through immunofluorescence. They would also be involved in identifying new small molecules in small-scale, targeted screens and pursuing other cells of interest, including stem cells from the stomach, ileum and colon.

Cellular Mechanisms Underlying Dormant Intestinal Stem Cell Activation
Summer, 06/17/14 - 08/15/14

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK123694 (BREAULT, DAVID T) Sep 19, 2019 - Aug 31, 2024
    Rosettes in Adrenal Development, Maintenance and Disease
    Role: Principal Investigator
  2. R01DK119488 (BREAULT, DAVID T) Sep 1, 2019 - May 31, 2023
    Regulation of the Intestinal Stem Cells During Regeneration
    Role: Principal Investigator
  3. R01DK100653 (BREAULT, DAVID T) Sep 12, 2013 - Jul 31, 2019
    Mechanisms of Adrenal Lineage Development
    Role: Principal Investigator
  4. R21CA158861 (BREAULT, DAVID T) Mar 1, 2012 - Aug 31, 2014
    Role of Slowly Cycling Stem Cells in Cancer
    Role: Principal Investigator
  5. R01DK084056 (BREAULT, DAVID T) Jul 1, 2010 - Jun 30, 2017
    Characterization of Telomerase Expressing Intestinal Stem Cells
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Omar MH, Byrne DP, Jones KN, Lakey TM, Collins KB, Lee KS, Daly LA, Forbush KA, Lau HT, Golkowski M, McKnight GS, Breault DT, Lefrançois-Martinez AM, Martinez A, Eyers CE, Baird GS, Ong SE, Smith FD, Eyers PA, Scott JD. Mislocalization of protein kinase A drives pathology in Cushing's syndrome. Cell Rep. 2022 07 12; 40(2):111073. PMID: 35830806; PMCID: PMC9311266.
    Citations:    Fields:    Translation:AnimalsCells
  2. Bein A, Fadel CW, Swenor B, Cao W, Powers RK, Camacho DM, Naziripour A, Parsons A, LoGrande N, Sharma S, Kim S, Jalili-Firoozinezhad S, Grant J, Breault DT, Iqbal J, Ali A, Denson LA, Moore SR, Prantil-Baun R, Goyal G, Ingber DE. Nutritional deficiency in an intestine-on-a-chip recapitulates injury hallmarks associated with environmental enteric dysfunction. Nat Biomed Eng. 2022 Jun 23. PMID: 35739419.
    Citations:    Fields:    
  3. Jensen GS, Willows JW, Breault DT, Townsend KL. Lineage Tracing of Inducible Fluorescently-Labeled Stem Cells in the Adult Mouse Brain. J Vis Exp. 2022 05 20; (183). PMID: 35661692.
    Citations:    Fields:    Translation:AnimalsCells
  4. Zuo L, Kuo WT, Cao F, Chanez-Paredes SD, Zeve D, Mannam P, Jean-François L, Day A, Vallen Graham W, Sweat YY, Shashikanth N, Breault DT, Turner JR. Tacrolimus-binding protein FKBP8 directs myosin light chain kinase-dependent barrier regulation and is a potential therapeutic target in Crohn's disease. Gut. 2022 May 10. PMID: 35537812.
    Citations:    Fields:    
  5. Grant J, Lee E, Almeida M, Kim S, LoGrande N, Goyal G, Sesay AM, Breault DT, Prantil-Baun R, Ingber DE. Establishment of physiologically relevant oxygen gradients in microfluidic organ chips. Lab Chip. 2022 04 12; 22(8):1584-1593. PMID: 35274118; PMCID: PMC9088163.
    Citations: 2     Fields:    Translation:Humans
  6. Sebastian C, Ferrer C, Serra M, Choi JE, Ducano N, Mira A, Shah MS, Stopka SA, Perciaccante AJ, Isella C, Moya-Rull D, Vara-Messler M, Giordano S, Maldi E, Desai N, Capen DE, Medico E, Cetinbas M, Sadreyev RI, Brown D, Rivera MN, Sapino A, Breault DT, Agar NYR, Mostoslavsky R. A non-dividing cell population with high pyruvate dehydrogenase kinase activity regulates metabolic heterogeneity and tumorigenesis in the intestine. Nat Commun. 2022 03 21; 13(1):1503. PMID: 35314684; PMCID: PMC8938512.
    Citations: 1     Fields:    Translation:AnimalsCells
  7. Xiong X, Tian S, Yang P, Lebreton F, Bao H, Sheng K, Yin L, Chen P, Zhang J, Qi W, Ruan J, Wu H, Chen H, Breault DT, Wu H, Earl AM, Gilmore MS, Abraham J, Dong M. Emerging enterococcus pore-forming toxins with MHC/HLA-I as receptors. Cell. 2022 03 31; 185(7):1157-1171.e22. PMID: 35259335; PMCID: PMC8978092.
    Citations: 1     Fields:    Translation:AnimalsCells
  8. Lynes MD, Carlone DL, Townsend KL, Breault DT, Tseng YH. Telomerase Reverse Transcriptase Expression Marks a Population of Rare Adipose Tissue Stem Cells. Stem Cells. 2022 03 03; 40(1):102-111. PMID: 35511869; PMCID: PMC9199842.
    Citations:    Fields:    Translation:AnimalsCells
  9. Zeve D, Stas E, de Sousa Casal J, Mannam P, Qi W, Yin X, Dubois S, Shah MS, Syverson EP, Hafner S, Karp JM, Carlone DL, Ordovas-Montanes J, Breault DT. Robust differentiation of human enteroendocrine cells from intestinal stem cells. Nat Commun. 2022 01 11; 13(1):261. PMID: 35017529; PMCID: PMC8752608.
    Citations:    Fields:    Translation:HumansCells
  10. Cambra HM, Tallapragada NP, Mannam P, Breault DT, Klein AM. Triple-Decker Sandwich Cultures of Intestinal Organoids for Long-Term Live Imaging, Uniform Perturbation, and Statistical Sampling. Curr Protoc. 2022 Jan; 2(1):e330. PMID: 35030297; PMCID: PMC9006308.
    Citations:    Fields:    Translation:AnimalsCells
  11. Zhang J, Hernandez-Gordillo V, Trapecar M, Wright C, Taketani M, Schneider K, Chen WLK, Stas E, Breault DT, Carrier RL, Voigt CA, Griffith LG. Coculture of primary human colon monolayer with human gut bacteria. Nat Protoc. 2021 08; 16(8):3874-3900. PMID: 34183870; PMCID: PMC9109719.
    Citations: 3     Fields:    Translation:HumansCells
  12. Leng S, Carlone DL, Guagliardo NA, Barrett PQ, Breault DT. Rosette morphology in zona glomerulosa formation and function. Mol Cell Endocrinol. 2021 06 15; 530:111287. PMID: 33891993; PMCID: PMC8159910.
    Citations:    Fields:    Translation:HumansAnimalsCells
  13. Carlone DL, Riba-Wolman RD, Deary LT, Tovaglieri A, Jiang L, Ambruzs DM, Mead BE, Shah MS, Lengner CJ, Jaenisch R, Breault DT. Telomerase expression marks transitional growth-associated skeletal progenitor/stem cells. Stem Cells. 2021 03; 39(3):296-305. PMID: 33438789.
    Citations: 3     Fields:    Translation:AnimalsCells
  14. Fasciano AC, Dasanayake GS, Estes MK, Zachos NC, Breault DT, Isberg RR, Tan S, Mecsas J. Yersinia pseudotuberculosis YopE prevents uptake by M cells and instigates M cell extrusion in human ileal enteroid-derived monolayers. Gut Microbes. 2021 Jan-Dec; 13(1):1988390. PMID: 34793276; PMCID: PMC8604394.
    Citations: 1     Fields:    Translation:HumansCells
  15. Zhu J, Breault DT. False-positive very long-chain fatty acids in a case of autoimmune adrenal insufficiency. J Pediatr Endocrinol Metab. 2021 Apr 27; 34(4):517-520. PMID: 33818043; PMCID: PMC9093155.
    Citations:    Fields:    Translation:HumansPHPublic Health
  16. He A, Huang Y, Cheng W, Zhang D, He W, Bai Y, Gu C, Ma Z, He Z, Si G, Chen B, Breault DT, Dong M, Xiang D. Organoid culture system for patient-derived lung metastatic osteosarcoma. Med Oncol. 2020 Oct 20; 37(11):105. PMID: 33079257.
    Citations: 3     Fields:    Translation:HumansCells
  17. Zhang J, Huang YJ, Yoon JY, Kemmitt J, Wright C, Schneider K, Sphabmixay P, Hernandez-Gordillo V, Holcomb SJ, Bhushan B, Rohatgi G, Benton K, Carpenter D, Kester JC, Eng G, Breault DT, Yilmaz O, Taketani M, Voigt CA, Carrier RL, Trumper DL, Griffith LG. Primary human colonic mucosal barrier crosstalk with super oxygen-sensitive Faecalibacterium prausnitzii in continuous culture. Med (N Y). 2021 01 15; 2(1):74-98.e9. PMID: 33511375; PMCID: PMC7839961.
    Citations: 13     Translation:HumansAnimalsCells
  18. Hosic S, Lake W, Stas E, Koppes R, Breault DT, Murthy SK, Koppes AN. Cholinergic Activation of Primary Human Derived Intestinal Epithelium Does Not Ameliorate TNF-a Induced Injury. Cell Mol Bioeng. 2020 Oct; 13(5):487-505. PMID: 33184579; PMCID: PMC7596162.
  19. Borges KS, Pignatti E, Leng S, Kariyawasam D, Ruiz-Babot G, Ramalho FS, Taketo MM, Carlone DL, Breault DT. Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene. 2020 07; 39(30):5282-5291. PMID: 32561853.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Hosic S, Bindas AJ, Puzan ML, Lake W, Soucy JR, Zhou F, Koppes RA, Breault DT, Murthy SK, Koppes AN. Rapid Prototyping of Multilayer Microphysiological Systems. ACS Biomater Sci Eng. 2021 07 12; 7(7):2949-2963. PMID: 34275297.
    Citations: 1     Fields:    Translation:HumansCells
  21. Hernandez-Gordillo V, Kassis T, Lampejo A, Choi G, Gamboa ME, Gnecco JS, Brown A, Breault DT, Carrier R, Griffith LG. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials. 2020 09; 254:120125. PMID: 32502894.
    Citations: 27     Fields:    Translation:HumansCells
  22. Pignatti E, Leng S, Yuchi Y, Borges KS, Guagliardo NA, Shah MS, Ruiz-Babot G, Kariyawasam D, Taketo MM, Miao J, Barrett PQ, Carlone DL, Breault DT. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. PMID: 32320669.
    Citations: 15     Fields:    Translation:Animals
  23. Guagliardo NA, Klein PM, Gancayco CA, Lu A, Leng S, Makarem RR, Cho C, Rusin CG, Breault DT, Barrett PQ, Beenhakker MP. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679. PMID: 32245948.
    Citations: 5     Fields:    Translation:Animals
  24. Leng S, Pignatti E, Khetani RS, Shah MS, Xu S, Miao J, Taketo MM, Beuschlein F, Barrett PQ, Carlone DL, Breault DT. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. PMID: 32245949.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  25. Pearce SC, Weber GJ, van Sambeek DM, Soares JW, Racicot K, Breault DT. Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PLoS One. 2020; 15(4):e0230231. PMID: 32240190.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  26. Taylor MJ, Ullenbruch MR, Frucci EC, Rege J, Ansorge MS, Gomez-Sanchez CE, Begum S, Laufer E, Breault DT, Rainey WE. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest. 2020 01 02; 130(1):83-93. PMID: 31738186; PMCID: PMC6934213.
    Citations: 5     Fields:    Translation:AnimalsCells
  27. Sontheimer-Phelps A, Chou DB, Tovaglieri A, Ferrante TC, Duckworth T, Fadel C, Frismantas V, Sutherland AD, Jalili-Firoozinezhad S, Kasendra M, Stas E, Weaver JC, Richmond CA, Levy O, Prantil-Baun R, Breault DT, Ingber DE. Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cell Mol Gastroenterol Hepatol. 2020; 9(3):507-526. PMID: 31778828.
    Citations: 51     Fields:    Translation:HumansCells
  28. Engeland WC, Massman L, Miller L, Leng S, Pignatti E, Pantano L, Carlone DL, Kofuji P, Breault DT. Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology. 2019 10 01; 160(10):2215-2229. PMID: 31398249; PMCID: PMC6735739.
    Citations: 5     Fields:    Translation:Animals
  29. Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE. Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul; 3(7):583. PMID: 31213704.
    Citations:    Fields:    
  30. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. PMID: 31160825; PMCID: PMC6754795.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  31. Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 07; 3(7):520-531. PMID: 31086325.
    Citations: 154     Fields:    Translation:HumansCells
  32. Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019 03 20; 7(1):43. PMID: 30890187; PMCID: PMC6425591.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  33. Guagliardo NA, Yao J, Stipes EJ, Cechova S, Le TH, Bayliss DA, Breault DT, Barrett PQ. Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension. 2019 02; 73(2):407-414. PMID: 30580687; PMCID: PMC6326871.
    Citations: 5     Fields:    Translation:Animals
  34. Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD. A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. Genes Dev. 2019 02 01; 33(3-4):209-220. PMID: 30692207; PMCID: PMC6362817.
    Citations: 24     Fields:    Translation:AnimalsCells
  35. Engeland WC, Massman L, Mishra S, Yoder JM, Leng S, Pignatti E, Piper ME, Carlone DL, Breault DT, Kofuji P. The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology. 2018 12 01; 159(12):3950-3964. PMID: 30321360; PMCID: PMC6240903.
    Citations: 9     Fields:    Translation:Animals
  36. Cousins FL, O DF, Ong YR, Breault DT, Deane JA, Gargett CE. Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. Stem Cells Dev. 2019 01 01; 28(1):1-12. PMID: 30358490.
    Citations: 1     Fields:    Translation:AnimalsCells
  37. Cherella CE, Breault DT, Thaker V, Levine BS, Smith JR. Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab. 2018 10 01; 103(10):3585-3588. PMID: 30085021; PMCID: PMC6179162.
    Citations: 3     Fields:    Translation:Humans
  38. Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018 11; 11(6):1684-1693. PMID: 30111863; PMCID: PMC6512331.
    Citations: 15     Fields:    Translation:Humans
  39. O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. PMID: 29909964.
    Citations: 4     Fields:    Translation:HumansCells
  40. Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A. Adrenocortical development: Lessons from mouse models. Ann Endocrinol (Paris). 2018 Jun; 79(3):95-97. PMID: 29673697.
    Citations: 4     Fields:    Translation:HumansAnimals
  41. Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 06; 38(6):1283-1296. PMID: 29599138.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. PMID: 29596476; PMCID: PMC5892915.
    Citations: 14     Fields:    Translation:AnimalsCells
  43. Richmond CA, Breault DT. Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cell Mol Gastroenterol Hepatol. 2018; 5(4):634-635. PMID: 29713662.
    Citations: 8     Fields:    
  44. Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 02 13; 8(1):2871. PMID: 29440725.
    Citations: 189     Fields:    Translation:HumansCells
  45. Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 01 25; 3(2). PMID: 29367455.
    Citations: 26     Fields:    Translation:AnimalsCells
  46. Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 01 09; 10(1):17-26. PMID: 29276155.
    Citations: 17     Fields:    Translation:AnimalsCells
  47. Ong YR, Cousins FL, Yang X, Mushafi AAAA, Breault DT, Gargett CE, Deane JA. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 01; 36(1):91-102. PMID: 28913973.
    Citations: 18     Fields:    Translation:AnimalsCells
  48. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. PMID: 28686870.
    Citations: 147     Fields:    Translation:AnimalsCells
  49. Toce MS, Stefater MA, Breault DT, Burns MM. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 01; 56(1):74-76. PMID: 28650702; PMCID: PMC5857189.
    Citations: 4     Fields:    Translation:Humans
  50. Stokes K, Cooke A, Chang H, Weaver DR, Breault DT, Karpowicz P. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. PMID: 28593182.
    Citations: 34     Fields:    
  51. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735; PMCID: PMC5043525.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  52. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. PMID: 27680706; PMCID: PMC5519134.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  53. Pignatti E, Leng S, Carlone DL, Breault DT. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 02 05; 441:146-155. PMID: 27619404; PMCID: PMC5235909.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  54. Richmond CA, Shah MS, Carlone DL, Breault DT. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. PMID: 27153394; PMCID: PMC4912863.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  55. Barrett PQ, Guagliardo NA, Klein PM, Hu C, Breault DT, Beenhakker MP. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. PMID: 26845064; PMCID: PMC5063946.
    Citations: 17     Fields:    Translation:HumansAnimals
  56. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146; PMCID: PMC4779391.
    Citations: 50     Fields:    Translation:AnimalsCells
  57. Richmond CA, Shah MS, Carlone DL, Breault DT. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. PMID: 26670741; PMCID: PMC5009802.
    Citations: 5     Fields:    Translation:AnimalsCells
  58. Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. PMID: 26740067; PMCID: PMC4816964.
    Citations: 9     Fields:    Translation:AnimalsCells
  59. Richmond CA, Shah MS, Deary LT, Trotier DC, Thomas H, Ambruzs DM, Jiang L, Whiles BB, Rickner HD, Montgomery RK, Tovaglieri A, Carlone DL, Breault DT. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. PMID: 26686631; PMCID: PMC4691543.
    Citations: 39     Fields:    Translation:AnimalsCells
  60. San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. PMID: 26489894.
    Citations: 21     Fields:    Translation:AnimalsCells
  61. D'Addio F, La Rosa S, Maestroni A, Jung P, Orsenigo E, Ben Nasr M, Tezza S, Bassi R, Finzi G, Marando A, Vergani A, Frego R, Albarello L, Andolfo A, Manuguerra R, Viale E, Staudacher C, Corradi D, Batlle E, Breault D, Secchi A, Folli F, Fiorina P. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. PMID: 26431183; PMCID: PMC4826279.
    Citations: 31     Fields:    Translation:HumansAnimalsCells
  62. Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. PMID: 26079371.
    Citations: 5     Fields:    Translation:AnimalsCells
  63. Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. PMID: 25127175.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  64. Meeson A, Fuller A, Breault DT, Owens WA, Richardson GD. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev Rep. 2013 Oct; 9(5):731-9. PMID: 23619929; PMCID: PMC4629417.
    Citations: 6     Fields:    Translation:AnimalsCells
  65. Freedman BD, Kempna PB, Carlone DL, Shah M, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE, Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. PMID: 24035414.
    Citations: 68     Fields:    Translation:AnimalsCells
  66. Richardson GD, Breault D, Horrocks G, Cormack S, Hole N, Owens WA. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. PMID: 22919071.
    Citations: 27     Fields:    Translation:Animals
  67. Kodama Y, Noda A, Booth C, Breault D, Suda T, Hendry J, Shinohara T, Rübe C, Nishimura EK, Mitani H, Nakamura N, Niwa O. International workshop: radiation effects on mutation in somatic and germline stem cells. Int J Radiat Biol. 2012 Jun; 88(6):501-6. PMID: 22489999.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  68. Carlone DL, Breault DT. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. PMID: 22226346.
    Citations: 16     Fields:    
  69. Song J, Czerniak S, Wang T, Ying W, Carlone DL, Breault DT, Humphreys BD. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. PMID: 22021716.
    Citations: 14     Fields:    Translation:AnimalsCells
  70. Carlone DL, Breault DT. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. Cell Cycle. 2011 Mar 01; 10(5):723-4. PMID: 21311229.
    Citations: 2     Fields:    Translation:AnimalsCells
  71. Auchus RJ, Witchel SF, Leight KR, Aisenberg J, Azziz R, Bachega TA, Baker LA, Baratz AB, Baskin LS, Berenbaum SA, Breault DT, Cerame BI, Conway GS, Eugster EA, Fracassa S, Gearhart JP, Geffner ME, Harris KB, Hurwitz RS, Katz AL, Kalro BN, Lee PA, Alger Lin G, Loechner KJ, Marshall I, Merke DP, Migeon CJ, Miller WL, Nenadovich TL, Oberfield SE, Pass KA, Poppas DP, Lloyd-Puryear MA, Quigley CA, Riepe FG, Rink RC, Rivkees SA, Sandberg DE, Schaeffer TL, Schlussel RN, Schneck FX, Seely EW, Snyder D, Speiser PW, Therrell BL, Vanryzin C, Vogiatzi MG, Wajnrajch MP, White PC, Zuckerman AE. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. PMID: 21274448.
    Citations: 16     
  72. Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. PMID: 21173232.
    Citations: 242     Fields:    Translation:AnimalsCells
  73. Richmond CA, Breault DT. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. PMID: 21075346.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  74. Breault DT, Min IM, Carlone DL, Farilla LG, Ambruzs DM, Henderson DE, Algra S, Montgomery RK, Wagers AJ, Hole N. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. PMID: 18650388.
    Citations: 65     Fields:    Translation:AnimalsCells
  75. Montgomery RK, Breault DT. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. PMID: 18638070.
    Citations: 51     Fields:    Translation:HumansCells
  76. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. PMID: 18371448; PMCID: PMC3538379.
    Citations: 356     Fields:    Translation:AnimalsCells
  77. Silverman ES, Breault DT, Vallone J, Subramanian S, Yilmaz AD, Mathew S, Subramaniam V, Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. PMID: 15480311.
    Citations: 21     Fields:    Translation:Animals
  78. Breault DT, Lichtler AC, Rowe DW. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. PMID: 9395449.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  79. Breault D, Lichtler A. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. PMID: 8837003.
    Citations:    Fields:    Translation:HumansAnimals
  80. Breault DT, Stover ML, Li M, Lichtler AC, Rowe DW. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. PMID: 7598891.
    Citations: 1     Fields:    Translation:Cells
  81. Fall PM, Breault DT, Raisz LG. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. PMID: 7872059.
    Citations: 5     Fields:    Translation:AnimalsCells
  82. Bedalov A, Breault DT, Sokolov BP, Lichtler AC, Bedalov I, Clark SH, Mack K, Khillan JS, Woody CO, Kream BE, et al. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. PMID: 8106463.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.