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David T. Breault, Ph.D., M.D.

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Overview

Mentoring
Available: 10/01/18, Expires: 05/01/22

Diabetes mellitus is a worldwide, ever-growing epidemic. Even though there have been incredible advances in the management of diabetes in recent years, a more permanent treatment for diabetes mellitus has remained elusive. Using genetic techniques and directed differentiation with small molecules, the scientific community has managed to create beta cells from multiple stem cell types; however, important issues remain regarding their viability, host immune response, risk for neoplasia as well ethical concerns. By using a patient’s own adult stem cells, one may be able to bypass these issues. Gastrointestinal (GI) stem cells are plentiful in mature gut, are easily accessible via endoscopy, and can be readily expanded and differentiated ex vivo into mature cell types, including enteroendocrine cells (EECs), which secrete incretin hormones that increase insulin release with food intake, in three-dimensional structures known as enteroids. Moreover, proof-of-principle studies in mice have shown that EE cells can be efficiently reprogrammed into insulin-secreting beta-like cells upon introduction of key beta cell transcription factors. Our preliminary studies show that human EE cells can be reprogrammed into insulin-expressing cells, albeit with reduced efficiency compared to the murine studies.

This project seeks to examine the ability of GI stem cells to produce incretin-secreting and insulin-secreting cells through small molecules. We anticipate that this could provide a novel, personalized treatment strategy in diabetes mellitus that circumvents the host immune response and the need for direct genetic modification. A medical student involved in this project would have a large role, along with a post-doc, in screening small molecules for their role in increasing enteroendocrine differentiation and increasing beta cell specific targets. This will involve in vitro culturing of human enteroids, isolating RNA and performing qualitative, real-time PCR, and examining protein expression through immunofluorescence. They would also be involved in identifying new small molecules in small-scale, targeted screens and pursuing other cells of interest, including stem cells from the stomach, ileum and colon.

Cellular Mechanisms Underlying Dormant Intestinal Stem Cell Activation
Summer, 06/17/14 - 08/15/14

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DK123694 (BREAULT, DAVID T) Sep 19, 2019 - Aug 31, 2024
    NIH/NIDDK
    Rosettes in Adrenal Development, Maintenance and Disease
    Role: Principal Investigator
  2. R01DK119488 (BREAULT, DAVID T) Sep 1, 2019 - May 31, 2023
    NIH/NIDDK
    Regulation of the Intestinal Stem Cells During Regeneration
    Role: Principal Investigator
  3. R01DK100653 (BREAULT, DAVID T) Sep 12, 2013 - Jul 31, 2017
    NIH/NIDDK
    Mechanisms of Adrenal Lineage Development
    Role: Principal Investigator
  4. R21CA158861 (BREAULT, DAVID T) Mar 1, 2012 - Feb 28, 2014
    NIH/NCI
    Role of Slowly Cycling Stem Cells in Cancer
    Role: Principal Investigator
  5. R01DK084056 (BREAULT, DAVID T) Jul 1, 2010 - Jun 30, 2016
    NIH/NIDDK
    Characterization of Telomerase Expressing Intestinal Stem Cells
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. He A, Huang Y, Cheng W, Zhang D, He W, Bai Y, Gu C, Ma Z, He Z, Si G, Chen B, Breault DT, Dong M, Xiang D. Organoid culture system for patient-derived lung metastatic osteosarcoma. Med Oncol. 2020 Oct 20; 37(11):105. PMID: 33079257.
    Citations:    Fields:    
  2. Borges KS, Pignatti E, Leng S, Kariyawasam D, Ruiz-Babot G, Ramalho FS, Taketo MM, Carlone DL, Breault DT. Wnt/ß-catenin activation cooperates with loss of p53 to cause adrenocortical carcinoma in mice. Oncogene. 2020 07; 39(30):5282-5291. PMID: 32561853.
    Citations:    Fields:    
  3. Hernandez-Gordillo V, Kassis T, Lampejo A, Choi G, Gamboa ME, Gnecco JS, Brown A, Breault DT, Carrier R, Griffith LG. Fully synthetic matrices for in vitro culture of primary human intestinal enteroids and endometrial organoids. Biomaterials. 2020 Sep; 254:120125. PMID: 32502894.
    Citations:    Fields:    
  4. Pignatti E, Leng S, Yuchi Y, Borges KS, Guagliardo NA, Shah MS, Ruiz-Babot G, Kariyawasam D, Taketo MM, Miao J, Barrett PQ, Carlone DL, Breault DT. Beta-Catenin Causes Adrenal Hyperplasia by Blocking Zonal Transdifferentiation. Cell Rep. 2020 04 21; 31(3):107524. PMID: 32320669.
    Citations: 1     Fields:    
  5. Leng S, Pignatti E, Khetani RS, Shah MS, Xu S, Miao J, Taketo MM, Beuschlein F, Barrett PQ, Carlone DL, Breault DT. ß-Catenin and FGFR2 regulate postnatal rosette-based adrenocortical morphogenesis. Nat Commun. 2020 04 03; 11(1):1680. PMID: 32245949.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  6. Guagliardo NA, Klein PM, Gancayco CA, Lu A, Leng S, Makarem RR, Cho C, Rusin CG, Breault DT, Barrett PQ, Beenhakker MP. Angiotensin II induces coordinated calcium bursts in aldosterone-producing adrenal rosettes. Nat Commun. 2020 04 03; 11(1):1679. PMID: 32245948.
    Citations:    Fields:    Translation:Animals
  7. Pearce SC, Weber GJ, van Sambeek DM, Soares JW, Racicot K, Breault DT. Intestinal enteroids recapitulate the effects of short-chain fatty acids on the intestinal epithelium. PLoS One. 2020; 15(4):e0230231. PMID: 32240190.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  8. Taylor MJ, Ullenbruch MR, Frucci EC, Rege J, Ansorge MS, Gomez-Sanchez CE, Begum S, Laufer E, Breault DT, Rainey WE. Chemogenetic activation of adrenocortical Gq signaling causes hyperaldosteronism and disrupts functional zonation. J Clin Invest. 2020 01 02; 130(1):83-93. PMID: 31738186.
    Citations:    Fields:    Translation:AnimalsCells
  9. Sontheimer-Phelps A, Chou DB, Tovaglieri A, Ferrante TC, Duckworth T, Fadel C, Frismantas V, Sutherland AD, Jalili-Firoozinezhad S, Kasendra M, Stas E, Weaver JC, Richmond CA, Levy O, Prantil-Baun R, Breault DT, Ingber DE. Human Colon-on-a-Chip Enables Continuous In Vitro Analysis of Colon Mucus Layer Accumulation and Physiology. Cell Mol Gastroenterol Hepatol. 2020; 9(3):507-526. PMID: 31778828.
    Citations: 7     Fields:    
  10. Engeland WC, Massman L, Miller L, Leng S, Pignatti E, Pantano L, Carlone DL, Kofuji P, Breault DT. Sex Differences in Adrenal Bmal1 Deletion-Induced Augmentation of Glucocorticoid Responses to Stress and ACTH in Mice. Endocrinology. 2019 10 01; 160(10):2215-2229. PMID: 31398249.
    Citations:    Fields:    Translation:Animals
  11. Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE. Author Correction: A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 Jul; 3(7):583. PMID: 31213704.
    Citations:    Fields:    
  12. Tao L, Tian S, Zhang J, Liu Z, Robinson-McCarthy L, Miyashita SI, Breault DT, Gerhard R, Oottamasathien S, Whelan SPJ, Dong M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells. Nat Microbiol. 2019 10; 4(10):1760-1769. PMID: 31160825.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  13. Jalili-Firoozinezhad S, Gazzaniga FS, Calamari EL, Camacho DM, Fadel CW, Bein A, Swenor B, Nestor B, Cronce MJ, Tovaglieri A, Levy O, Gregory KE, Breault DT, Cabral JMS, Kasper DL, Novak R, Ingber DE. A complex human gut microbiome cultured in an anaerobic intestine-on-a-chip. Nat Biomed Eng. 2019 07; 3(7):520-531. PMID: 31086325.
    Citations: 30     Fields:    Translation:HumansCells
  14. Tovaglieri A, Sontheimer-Phelps A, Geirnaert A, Prantil-Baun R, Camacho DM, Chou DB, Jalili-Firoozinezhad S, de Wouters T, Kasendra M, Super M, Cartwright MJ, Richmond CA, Breault DT, Lacroix C, Ingber DE. Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. Microbiome. 2019 03 20; 7(1):43. PMID: 30890187.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  15. Guagliardo NA, Yao J, Stipes EJ, Cechova S, Le TH, Bayliss DA, Breault DT, Barrett PQ. Adrenal Tissue-Specific Deletion of TASK Channels Causes Aldosterone-Driven Angiotensin II-Independent Hypertension. Hypertension. 2019 02; 73(2):407-414. PMID: 30580687.
    Citations: 2     Fields:    Translation:Animals
  16. Basham KJ, Rodriguez S, Turcu AF, Lerario AM, Logan CY, Rysztak MR, Gomez-Sanchez CE, Breault DT, Koo BK, Clevers H, Nusse R, Val P, Hammer GD. A ZNRF3-dependent Wnt/ß-catenin signaling gradient is required for adrenal homeostasis. Genes Dev. 2019 02 01; 33(3-4):209-220. PMID: 30692207.
    Citations: 7     Fields:    Translation:AnimalsCells
  17. Engeland WC, Massman L, Mishra S, Yoder JM, Leng S, Pignatti E, Piper ME, Carlone DL, Breault DT, Kofuji P. The Adrenal Clock Prevents Aberrant Light-Induced Alterations in Circadian Glucocorticoid Rhythms. Endocrinology. 2018 12 01; 159(12):3950-3964. PMID: 30321360.
    Citations: 3     Fields:    Translation:Animals
  18. Cousins FL, O DF, Ong YR, Breault DT, Deane JA, Gargett CE. Telomerase Reverse Transcriptase Expression in Mouse Endometrium During Reepithelialization and Regeneration in a Menses-Like Model. Stem Cells Dev. 2019 01 01; 28(1):1-12. PMID: 30358490.
    Citations:    Fields:    Translation:AnimalsCells
  19. Cherella CE, Breault DT, Thaker V, Levine BS, Smith JR. Early Identification of Primary Hypothyroidism in Neonates Exposed to Intralymphatic Iodinated Contrast: A Case Series. J Clin Endocrinol Metab. 2018 10 01; 103(10):3585-3588. PMID: 30085021.
    Citations:    Fields:    Translation:Humans
  20. Konnikova L, Boschetti G, Rahman A, Mitsialis V, Lord J, Richmond C, Tomov VT, Gordon W, Jelinsky S, Canavan J, Liss A, Wall S, Field M, Zhou F, Goldsmith JD, Bewtra M, Breault DT, Merad M, Snapper SB. High-dimensional immune phenotyping and transcriptional analyses reveal robust recovery of viable human immune and epithelial cells from frozen gastrointestinal tissue. Mucosal Immunol. 2018 11; 11(6):1684-1693. PMID: 30111863.
    Citations: 4     Fields:    Translation:Humans
  21. O'Connell AE, Zhou F, Shah MS, Murphy Q, Rickner H, Kelsen J, Boyle J, Doyle JJ, Gangwani B, Thiagarajah JR, Kamin DS, Goldsmith JD, Richmond C, Breault DT, Agrawal PB. Neonatal-Onset Chronic Diarrhea Caused by Homozygous Nonsense WNT2B Mutations. Am J Hum Genet. 2018 07 05; 103(1):131-137. PMID: 29909964.
    Citations: 2     Fields:    Translation:HumansCells
  22. Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A. Adrenocortical development: Lessons from mouse models. Ann Endocrinol (Paris). 2018 Jun; 79(3):95-97. PMID: 29673697.
    Citations:    Fields:    Translation:HumansAnimals
  23. Richardson GD, Sage A, Bennaceur K, Al Zhrany N, Coelho-Lima J, Dookun E, Draganova L, Saretzki G, Breault DT, Mallat Z, Spyridopoulos I. Telomerase Mediates Lymphocyte Proliferation but Not the Atherosclerosis-Suppressive Potential of Regulatory T-Cells. Arterioscler Thromb Vasc Biol. 2018 06; 38(6):1283-1296. PMID: 29599138.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Lyons J, Ghazi PC, Starchenko A, Tovaglieri A, Baldwin KR, Poulin EJ, Gierut JJ, Genetti C, Yajnik V, Breault DT, Lauffenburger DA, Haigis KM. The colonic epithelium plays an active role in promoting colitis by shaping the tissue cytokine profile. PLoS Biol. 2018 03; 16(3):e2002417. PMID: 29596476.
    Citations: 2     Fields:    Translation:AnimalsCells
  25. Richmond CA, Breault DT. Move Over Caco-2 Cells: Human-Induced Organoids Meet Gut-on-a-Chip. Cell Mol Gastroenterol Hepatol. 2018; 5(4):634-635. PMID: 29713662.
    Citations: 2     Fields:    
  26. Kasendra M, Tovaglieri A, Sontheimer-Phelps A, Jalili-Firoozinezhad S, Bein A, Chalkiadaki A, Scholl W, Zhang C, Rickner H, Richmond CA, Li H, Breault DT, Ingber DE. Development of a primary human Small Intestine-on-a-Chip using biopsy-derived organoids. Sci Rep. 2018 02 13; 8(1):2871. PMID: 29440725.
    Citations: 51     Fields:    Translation:HumansCells
  27. Dumontet T, Sahut-Barnola I, Septier A, Montanier N, Plotton I, Roucher-Boulez F, Ducros V, Lefrançois-Martinez AM, Pointud JC, Zubair M, Morohashi KI, Breault DT, Val P, Martinez A. PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal. JCI Insight. 2018 01 25; 3(2). PMID: 29367455.
    Citations: 7     Fields:    Translation:AnimalsCells
  28. Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 01 09; 10(1):17-26. PMID: 29276155.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Ong YR, Cousins FL, Yang X, Mushafi AAAA, Breault DT, Gargett CE, Deane JA. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 01; 36(1):91-102. PMID: 28913973.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 07 06; 21(1):78-90.e6. PMID: 28686870.
    Citations: 59     Fields:    Translation:AnimalsCells
  31. Toce MS, Stefater MA, Breault DT, Burns MM. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 01; 56(1):74-76. PMID: 28650702.
    Citations: 1     Fields:    Translation:Humans
  32. Stokes K, Cooke A, Chang H, Weaver DR, Breault DT, Karpowicz P. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. PMID: 28593182.
    Citations: 11     Fields:    
  33. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  34. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. PMID: 27680706.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  35. Pignatti E, Leng S, Carlone DL, Breault DT. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 02 05; 441:146-155. PMID: 27619404.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  36. Richmond CA, Shah MS, Carlone DL, Breault DT. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. PMID: 27153394.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  37. Barrett PQ, Guagliardo NA, Klein PM, Hu C, Breault DT, Beenhakker MP. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. PMID: 26845064.
    Citations: 11     Fields:    Translation:HumansAnimals
  38. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146.
    Citations: 35     Fields:    Translation:AnimalsCells
  39. Richmond CA, Shah MS, Carlone DL, Breault DT. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. PMID: 26670741.
    Citations: 4     Fields:    Translation:AnimalsCells
  40. Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. PMID: 26740067.
    Citations: 4     Fields:    Translation:AnimalsCells
  41. Richmond CA, Shah MS, Deary LT, Trotier DC, Thomas H, Ambruzs DM, Jiang L, Whiles BB, Rickner HD, Montgomery RK, Tovaglieri A, Carlone DL, Breault DT. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. PMID: 26686631.
    Citations: 26     Fields:    Translation:AnimalsCells
  42. San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. PMID: 26489894.
    Citations: 11     Fields:    Translation:AnimalsCells
  43. D'Addio F, La Rosa S, Maestroni A, Jung P, Orsenigo E, Ben Nasr M, Tezza S, Bassi R, Finzi G, Marando A, Vergani A, Frego R, Albarello L, Andolfo A, Manuguerra R, Viale E, Staudacher C, Corradi D, Batlle E, Breault D, Secchi A, Folli F, Fiorina P. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. PMID: 26431183.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  44. Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. PMID: 26079371.
    Citations: 2     Fields:    Translation:AnimalsCells
  45. Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. PMID: 25127175.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  46. Meeson A, Fuller A, Breault DT, Owens WA, Richardson GD. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev Rep. 2013 Oct; 9(5):731-9. PMID: 23619929.
    Citations: 2     Fields:    Translation:AnimalsCells
  47. Freedman BD, Kempna PB, Carlone DL, Shah M, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE, Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. PMID: 24035414.
    Citations: 45     Fields:    Translation:AnimalsCells
  48. Richardson GD, Breault D, Horrocks G, Cormack S, Hole N, Owens WA. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. PMID: 22919071.
    Citations: 16     Fields:    Translation:Animals
  49. Kodama Y, Noda A, Booth C, Breault D, Suda T, Hendry J, Shinohara T, Rübe C, Nishimura EK, Mitani H, Nakamura N, Niwa O. International workshop: radiation effects on mutation in somatic and germline stem cells. Int J Radiat Biol. 2012 Jun; 88(6):501-6. PMID: 22489999.
    Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  50. Carlone DL, Breault DT. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. PMID: 22226346.
    Citations: 14     Fields:    
  51. Song J, Czerniak S, Wang T, Ying W, Carlone DL, Breault DT, Humphreys BD. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. PMID: 22021716.
    Citations: 12     Fields:    Translation:AnimalsCells
  52. Carlone DL, Breault DT. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. . 2011 Mar 01; 10(5):723-4. PMID: 21311229.
    Citations: 2     Translation:AnimalsCells
  53. Auchus RJ, Witchel SF, Leight KR, Aisenberg J, Azziz R, Bachega TA, Baker LA, Baratz AB, Baskin LS, Berenbaum SA, Breault DT, Cerame BI, Conway GS, Eugster EA, Fracassa S, Gearhart JP, Geffner ME, Harris KB, Hurwitz RS, Katz AL, Kalro BN, Lee PA, Alger Lin G, Loechner KJ, Marshall I, Merke DP, Migeon CJ, Miller WL, Nenadovich TL, Oberfield SE, Pass KA, Poppas DP, Lloyd-Puryear MA, Quigley CA, Riepe FG, Rink RC, Rivkees SA, Sandberg DE, Schaeffer TL, Schlussel RN, Schneck FX, Seely EW, Snyder D, Speiser PW, Therrell BL, Vanryzin C, Vogiatzi MG, Wajnrajch MP, White PC, Zuckerman AE. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. PMID: 21274448.
    Citations: 12     
  54. Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. PMID: 21173232.
    Citations: 190     Fields:    Translation:AnimalsCells
  55. Richmond CA, Breault DT. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. PMID: 21075346.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  56. Breault DT, Min IM, Carlone DL, Farilla LG, Ambruzs DM, Henderson DE, Algra S, Montgomery RK, Wagers AJ, Hole N. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. PMID: 18650388.
    Citations: 56     Fields:    Translation:AnimalsCells
  57. Montgomery RK, Breault DT. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. PMID: 18638070.
    Citations: 45     Fields:    Translation:HumansCells
  58. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. PMID: 18371448.
    Citations: 327     Fields:    Translation:AnimalsCells
  59. Silverman ES, Breault DT, Vallone J, Subramanian S, Yilmaz AD, Mathew S, Subramaniam V, Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. PMID: 15480311.
    Citations: 18     Fields:    Translation:Animals
  60. Breault DT, Lichtler AC, Rowe DW. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. PMID: 9395449.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  61. Breault D, Lichtler A. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. PMID: 8837003.
    Citations:    Fields:    Translation:HumansAnimals
  62. Breault DT, Stover ML, Li M, Lichtler AC, Rowe DW. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. PMID: 7598891.
    Citations: 1     Fields:    Translation:Cells
  63. Fall PM, Breault DT, Raisz LG. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. PMID: 7872059.
    Citations: 5     Fields:    Translation:AnimalsCells
  64. Bedalov A, Breault DT, Sokolov BP, Lichtler AC, Bedalov I, Clark SH, Mack K, Khillan JS, Woody CO, Kream BE, et al. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. PMID: 8106463.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.