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profileDavid T. Breault, Ph.D., M.D.

TitleAssociate Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildren's Hospital
Endocrinology, CLS 16 026
300 Longwood Ave
Boston MA 02115
Phone617/919-2863
Fax617/730-0244
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Collapse Overview 

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Cellular Mechanisms Underlying Dormant Intestinal Stem Cell Activation
Summer, 06/17/14 - 08/15/14

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01DK100653     (BREAULT, DAVID T)Sep 12, 2013 - Jul 31, 2017
NIH/NIDDK
Mechanisms of Adrenal Lineage Development
Role: Principal Investigator

R21CA158861     (BREAULT, DAVID T)Mar 1, 2012 - Feb 28, 2014
NIH/NCI
Role of Slowly Cycling Stem Cells in Cancer
Role: Principal Investigator

R01DK084056     (BREAULT, DAVID T)Jul 1, 2010 - Jun 30, 2016
NIH/NIDDK
Characterization of Telomerase Expressing Intestinal Stem Cells
Role: Principal Investigator

R21DK078198     (BREAULT, DAVID T)Jul 1, 2007 - Jun 30, 2010
NIH/NIDDK
mTert-GFP and Pancreatic Progenitor Cells
Role: Principal Investigator

K08DK066305     (BREAULT, DAVID T)Jul 1, 2004 - Oct 1, 2009
NIH/NIDDK
Adrenal Regeneration: Stem Cells and Lineage Development
Role: Principal Investigator
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in the eagle-i Network. To update or add resource records, contact
eagle-i@hms.harvard.edu.
Breault Lab - Mouse strains (2) and Plasmids (2)

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Richmond CA, Rickner H, Shah MS, Ediger T, Deary L, Zhou F, Tovaglieri A, Carlone DL, Breault DT. JAK/STAT-1 Signaling Is Required for Reserve Intestinal Stem Cell Activation during Intestinal Regeneration Following Acute Inflammation. Stem Cell Reports. 2018 Jan 09; 10(1):17-26. PMID: 29276155.
    View in: PubMed
  2. Ong YR, Cousins FL, Yang X, Mushafi AAAA, Breault DT, Gargett CE, Deane JA. Bone Marrow Stem Cells Do Not Contribute to Endometrial Cell Lineages in Chimeric Mouse Models. Stem Cells. 2018 Jan; 36(1):91-102. PMID: 28913973.
    View in: PubMed
  3. Yan KS, Gevaert O, Zheng GXY, Anchang B, Probert CS, Larkin KA, Davies PS, Cheng ZF, Kaddis JS, Han A, Roelf K, Calderon RI, Cynn E, Hu X, Mandleywala K, Wilhelmy J, Grimes SM, Corney DC, Boutet SC, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Wang F, von Furstenberg RJ, Smith NR, Chandrakesan P, May R, Chrissy MAS, Jain R, Cartwright CA, Niland JC, Hong YK, Carrington J, Breault DT, Epstein J, Houchen CW, Lynch JP, Martin MG, Plevritis SK, Curtis C, Ji HP, Li L, Henning SJ, Wong MH, Kuo CJ. Intestinal Enteroendocrine Lineage Cells Possess Homeostatic and Injury-Inducible Stem Cell Activity. Cell Stem Cell. 2017 Jul 06; 21(1):78-90.e6. PMID: 28686870.
    View in: PubMed
  4. Toce MS, Stefater MA, Breault DT, Burns MM. A case report of methadone-associated hypoglycemia in an 11-month-old male. Clin Toxicol (Phila). 2018 Jan; 56(1):74-76. PMID: 28650702.
    View in: PubMed
  5. Stokes K, Cooke A, Chang H, Weaver DR, Breault DT, Karpowicz P. The Circadian Clock Gene BMAL1 Coordinates Intestinal Regeneration. Cell Mol Gastroenterol Hepatol. 2017 Jul; 4(1):95-114. PMID: 28593182.
    View in: PubMed
  6. Nelms BD, Waldron L, Barrera LA, Weflen AW, Goettel JA, Guo G, Montgomery RK, Neutra MR, Breault DT, Snapper SB, Orkin SH, Bulyk ML, Huttenhower C, Lencer WI. CellMapper: rapid and accurate inference of gene expression in difficult-to-isolate cell types. Genome Biol. 2016 09 29; 17(1):201. PMID: 27687735.
    View in: PubMed
  7. Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M. Frizzled proteins are colonic epithelial receptors for C. difficile toxin B. Nature. 2016 Oct 20; 538(7625):350-355. PMID: 27680706.
    View in: PubMed
  8. Pignatti E, Leng S, Carlone DL, Breault DT. Regulation of zonation and homeostasis in the adrenal cortex. Mol Cell Endocrinol. 2017 Feb 05; 441:146-155. PMID: 27619404.
    View in: PubMed
  9. Richmond CA, Shah MS, Carlone DL, Breault DT. An enduring role for quiescent stem cells. Dev Dyn. 2016 07; 245(7):718-26. PMID: 27153394; PMCID: PMC4912863 [Available on 07/01/17].
  10. Barrett PQ, Guagliardo NA, Klein PM, Hu C, Breault DT, Beenhakker MP. Role of voltage-gated calcium channels in the regulation of aldosterone production from zona glomerulosa cells of the adrenal cortex. J Physiol. 2016 10 15; 594(20):5851-5860. PMID: 26845064.
    View in: PubMed
  11. Ariyachet C, Tovaglieri A, Xiang G, Lu J, Shah MS, Richmond CA, Verbeke C, Melton DA, Stanger BZ, Mooney D, Shivdasani RA, Mahony S, Xia Q, Breault DT, Zhou Q. Reprogrammed Stomach Tissue as a Renewable Source of Functional ß Cells for Blood Glucose Regulation. Cell Stem Cell. 2016 Mar 03; 18(3):410-21. PMID: 26908146; PMCID: PMC4779391 [Available on 03/03/17].
  12. Richmond CA, Shah MS, Carlone DL, Breault DT. Factors regulating quiescent stem cells: insights from the intestine and other self-renewing tissues. J Physiol. 2016 09 01; 594(17):4805-13. PMID: 26670741; PMCID: PMC5009802 [Available on 09/01/17].
  13. Deane JA, Ong YR, Cain JE, Jayasekara WS, Tiwari A, Carlone DL, Watkins DN, Breault DT, Gargett CE. The mouse endometrium contains epithelial, endothelial and leucocyte populations expressing the stem cell marker telomerase reverse transcriptase. Mol Hum Reprod. 2016 Apr; 22(4):272-84. PMID: 26740067; PMCID: PMC4816964 [Available on 04/01/17].
  14. Richmond CA, Shah MS, Deary LT, Trotier DC, Thomas H, Ambruzs DM, Jiang L, Whiles BB, Rickner HD, Montgomery RK, Tovaglieri A, Carlone DL, Breault DT. Dormant Intestinal Stem Cells Are Regulated by PTEN and Nutritional Status. Cell Rep. 2015 Dec 22; 13(11):2403-2411. PMID: 26686631; PMCID: PMC4691543.
  15. San Roman AK, Tovaglieri A, Breault DT, Shivdasani RA. Distinct Processes and Transcriptional Targets Underlie CDX2 Requirements in Intestinal Stem Cells and Differentiated Villus Cells. Stem Cell Reports. 2015 Nov 10; 5(5):673-681. PMID: 26489894; PMCID: PMC4649135.
  16. D'Addio F, La Rosa S, Maestroni A, Jung P, Orsenigo E, Ben Nasr M, Tezza S, Bassi R, Finzi G, Marando A, Vergani A, Frego R, Albarello L, Andolfo A, Manuguerra R, Viale E, Staudacher C, Corradi D, Batlle E, Breault D, Secchi A, Folli F, Fiorina P. Circulating IGF-I and IGFBP3 Levels Control Human Colonic Stem Cell Function and Are Disrupted in Diabetic Enteropathy. Cell Stem Cell. 2015 10 01; 17(4):486-498. PMID: 26431183; PMCID: PMC4826279.
  17. Gierut JJ, Lyons J, Shah MS, Genetti C, Breault DT, Haigis KM. Oncogenic K-Ras promotes proliferation in quiescent intestinal stem cells. Stem Cell Res. 2015 Jul; 15(1):165-71. PMID: 26079371; PMCID: PMC4629819.
  18. Bennaceur K, Atwill M, Al Zhrany N, Hoffmann J, Keavney B, Breault D, Richardson G, von Zglinicki T, Saretzki G, Spyridopoulos I. Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism. Atherosclerosis. 2014 Oct; 236(2):312-20. PMID: 25127175.
    View in: PubMed
  19. Meeson A, Fuller A, Breault DT, Owens WA, Richardson GD. Optimised protocols for the identification of the murine cardiac side population. Stem Cell Rev. 2013 Oct; 9(5):731-9. PMID: 23619929; PMCID: PMC4629417.
  20. Freedman BD, Kempna PB, Carlone DL, Shah M, Guagliardo NA, Barrett PQ, Gomez-Sanchez CE, Majzoub JA, Breault DT. Adrenocortical zonation results from lineage conversion of differentiated zona glomerulosa cells. Dev Cell. 2013 Sep 30; 26(6):666-673. PMID: 24035414; PMCID: PMC3791142.
  21. Richardson GD, Breault D, Horrocks G, Cormack S, Hole N, Owens WA. Telomerase expression in the mammalian heart. FASEB J. 2012 Dec; 26(12):4832-40. PMID: 22919071; PMCID: PMC3509052.
  22. Carlone DL, Breault DT. Tales from the crypt: the expanding role of slow cycling intestinal stem cells. Cell Stem Cell. 2012 Jan 06; 10(1):2-4. PMID: 22226346; PMCID: PMC3674024.
  23. Song J, Czerniak S, Wang T, Ying W, Carlone DL, Breault DT, Humphreys BD. Characterization and fate of telomerase-expressing epithelia during kidney repair. J Am Soc Nephrol. 2011 Dec; 22(12):2256-65. PMID: 22021716; PMCID: PMC3250207.
  24. Carlone DL, Breault DT. Slowly cycling versus rapidly cycling intestinal stem cells: distinct roles or redundancy. Cell Cycle. 2011 Mar 01; 10(5):723-4. PMID: 21311229.
    View in: PubMed
  25. Auchus RJ, Witchel SF, Leight KR, Aisenberg J, Azziz R, Bachega TA, Baker LA, Baratz AB, Baskin LS, Berenbaum SA, Breault DT, Cerame BI, Conway GS, Eugster EA, Fracassa S, Gearhart JP, Geffner ME, Harris KB, Hurwitz RS, Katz AL, Kalro BN, Lee PA, Alger Lin G, Loechner KJ, Marshall I, Merke DP, Migeon CJ, Miller WL, Nenadovich TL, Oberfield SE, Pass KA, Poppas DP, Lloyd-Puryear MA, Quigley CA, Riepe FG, Rink RC, Rivkees SA, Sandberg DE, Schaeffer TL, Schlussel RN, Schneck FX, Seely EW, Snyder D, Speiser PW, Therrell BL, Vanryzin C, Vogiatzi MG, Wajnrajch MP, White PC, Zuckerman AE. Guidelines for the Development of Comprehensive Care Centers for Congenital Adrenal Hyperplasia: Guidance from the CARES Foundation Initiative. Int J Pediatr Endocrinol. 2010; 2010:275213. PMID: 21274448; PMCID: PMC3025377.
  26. Montgomery RK, Carlone DL, Richmond CA, Farilla L, Kranendonk ME, Henderson DE, Baffour-Awuah NY, Ambruzs DM, Fogli LK, Algra S, Breault DT. Mouse telomerase reverse transcriptase (mTert) expression marks slowly cycling intestinal stem cells. Proc Natl Acad Sci U S A. 2011 Jan 04; 108(1):179-84. PMID: 21173232; PMCID: PMC3017192.
  27. Richmond CA, Breault DT. Regulation of gene expression in the intestinal epithelium. Prog Mol Biol Transl Sci. 2010; 96:207-29. PMID: 21075346; PMCID: PMC3684064.
  28. Breault DT, Min IM, Carlone DL, Farilla LG, Ambruzs DM, Henderson DE, Algra S, Montgomery RK, Wagers AJ, Hole N. Generation of mTert-GFP mice as a model to identify and study tissue progenitor cells. Proc Natl Acad Sci U S A. 2008 Jul 29; 105(30):10420-5. PMID: 18650388; PMCID: PMC2492454.
  29. Montgomery RK, Breault DT. Small intestinal stem cell markers. J Anat. 2008 Jul; 213(1):52-8. PMID: 18638070; PMCID: PMC2475558.
  30. Stadtfeld M, Maherali N, Breault DT, Hochedlinger K. Defining molecular cornerstones during fibroblast to iPS cell reprogramming in mouse. Cell Stem Cell. 2008 Mar 06; 2(3):230-40. PMID: 18371448; PMCID: PMC3538379.
  31. Silverman ES, Breault DT, Vallone J, Subramanian S, Yilmaz AD, Mathew S, Subramaniam V, Tantisira K, Pacák K, Weiss ST, Majzoub JA. Corticotropin-releasing hormone deficiency increases allergen-induced airway inflammation in a mouse model of asthma. J Allergy Clin Immunol. 2004 Oct; 114(4):747-54. PMID: 15480311.
    View in: PubMed
  32. Breault DT, Lichtler AC, Rowe DW. COL1A1 transgene expression in stably transfected osteoblastic cells. Relative contributions of first intron, 3'-flanking sequences, and sequences derived from the body of the human COL1A1 minigene. J Biol Chem. 1997 Dec 12; 272(50):31241-50. PMID: 9395449.
    View in: PubMed
  33. Breault D, Lichtler A. Role of the first intron in the regulation of the COL 1A1 gene. Matrix Biol. 1996 Jul; 15(2):62-3; author reply 70. PMID: 8837003.
    View in: PubMed
  34. Breault DT, Stover ML, Li M, Lichtler AC, Rowe DW. Novel use for BAL 31 nuclease-generated nested deletions: sequencing from the inside out. Biotechniques. 1995 Apr; 18(4):614-7. PMID: 7598891.
    View in: PubMed
  35. Fall PM, Breault DT, Raisz LG. Inhibition of collagen synthesis by prostaglandins in the immortalized rat osteoblastic cell line Py1a: structure-activity relations and signal transduction mechanisms. J Bone Miner Res. 1994 Dec; 9(12):1935-43. PMID: 7872059.
    View in: PubMed
  36. Bedalov A, Breault DT, Sokolov BP, Lichtler AC, Bedalov I, Clark SH, Mack K, Khillan JS, Woody CO, Kream BE, et al. Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle cells. Comparison with other alpha 1(I) collagen-producing cells in transgenic animals and cultured cells. J Biol Chem. 1994 Feb 18; 269(7):4903-9. PMID: 8106463.
    View in: PubMed
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