Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Guo-Ping Shi, SC.D., D.SC.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R56AG058670 (SHI, GUO-PING) Sep 30, 2018 - Aug 31, 2019
    Role of mast cells in Alzheimer's Disease
    Role: Principal Investigator
  2. R01HL123568 (SHI, GUO-PING) Aug 21, 2015 - May 31, 2019
    Role of a novel IL18 binding protein in atherosclerosis
    Role: Principal Investigator
  3. R01HL088547 (SHI, GUO-PING) Jul 1, 2008 - Jun 30, 2013
    Role of mast cells in abdominal aortic aneurysms
    Role: Principal Investigator
  4. R01HL081090 (SHI, GUO-PING) Jul 1, 2005 - Feb 29, 2016
    Role of IgE in Atherosclerosis
    Role: Principal Investigator
  5. R01HL067283 (SHI, GUO-PING) Sep 30, 2003 - Aug 31, 2008
    The IL-18/Caspase-1 cascade in atherosclerosis
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Zhao R, He XW, Shi YH, Liu YS, Liu FD, Hu Y, Zhuang MT, Feng XY, Zhao L, Zhao BQ, Liu HQ, Shi GP, Liu JR. Cathepsin K Knockout Exacerbates Haemorrhagic Transformation Induced by Recombinant Tissue Plasminogen Activator After Focal Cerebral Ischaemia in Mice. Cell Mol Neurobiol. 2019 Aug; 39(6):823-831. PMID: 31065924.
  2. Zhang X, Huang Q, Wang X, Deng Z, Li J, Yan X, Jauhiainen M, Metso J, Libby P, Liu J, Shi GP. Dietary cholesterol is essential to mast cell activation and associated obesity and diabetes in mice. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 01; 1865(6):1690-1700. PMID: 30978390.
  3. Li J, Xia N, Wen S, Li D, Lu Y, Gu M, Tang T, Jiao J, Lv B, Nie S, Liao M, Liao Y, Yang X, Hu Y, Shi GP, Cheng X. IL (Interleukin)-33 Suppresses Abdominal Aortic Aneurysm by Enhancing Regulatory T-Cell Expansion and Activity. Arterioscler Thromb Vasc Biol. 2019 Mar; 39(3):446-458. PMID: 30651000.
    Citations:    Fields:    
  4. Chen ZH, Han XY, Lin ZY, Fan YL, Shi G, Zhang S, Zhang M. Facile reflux synthesis of polyethyleneimine-capped fluorescent carbon dots for sequential bioassays toward Cu2+ /H2 S and its application for a logic system. Biotechnol Appl Biochem. 2019 Feb 22. PMID: 30806989.
  5. Pu C, Xu Y, Liu Q, Zhu A, Shi G. Enantiomers of Single Chirality Nanotube as Chiral Recognition Interface for Enhanced Electrochemical Chiral Analysis. Anal Chem. 2019 Feb 19; 91(4):3015-3020. PMID: 30644729.
    Citations:    Fields:    
  6. He A, Fang W, Zhao K, Wang Y, Li J, Yang C, Benadjaoud F, Shi GP. Mast cell-deficiency protects mice from streptozotocin-induced diabetic cardiomyopathy. Transl Res. 2019 Jun; 208:1-14. PMID: 30738862.
  7. Wang Y, Liu CL, Fang W, Zhang X, Yang C, Li J, Liu J, Sukhova GK, Gurish MF, Libby P, Shi GP, Zhang J. Deficiency of mouse mast cell protease 4 mitigates cardiac dysfunctions in mice after myocardium infarction. Biochim Biophys Acta Mol Basis Dis. 2019 Jun 01; 1865(6):1170-1181. PMID: 30639224.
  8. Tang H, Cai D, Ren T, Xiong P, Liu Y, Gu H, Shi G. Fabrication of a low background signal glucose biosensor with 3D network materials as the electrocatalyst. Anal Biochem. 2019 Feb 15; 567:63-71. PMID: 30571945.
    Citations:    Fields:    
  9. Fang W, He A, Xiang MX, Lin Y, Wang Y, Li J, Yang C, Zhang X, Liu CL, Sukhova GK, Barascuk N, Larsen L, Karsdal M, Libby P, Shi GP. Cathepsin K-deficiency impairs mouse cardiac function after myocardial infarction. J Mol Cell Cardiol. 2019 Feb; 127:44-56. PMID: 30465799.
    Citations:    Fields:    
  10. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2018 11 01; 128(11):5184. PMID: 30382945.
    Citations:    Fields:    
  11. Wang Y, Liu CL, Lindholt JS, Shi GP, Zhang J. Plasma Cystatin B Association With Abdominal Aortic Aneurysms and Need for Later Surgical Repair: A Sub-study of the VIVA Trial. Eur J Vasc Endovasc Surg. 2018 Dec; 56(6):826-832. PMID: 30262158.
  12. Ouyang Q, Huang Q, Jiang Z, Zhao J, Shi GP, Yang M. Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis. Mol Immunol. 2018 09; 101:531-538. PMID: 30172209.
    Citations:    Fields:    
  13. Chen ZH, Han XY, Deng LX, Lin ZY, Mu FY, Zhang S, Shi G, Zhang M. A self-calibrating logic system and oxidase-based biosensor using Tb3+-doped carbon dots/DNA conjugates. Talanta. 2019 Jan 01; 191:235-240. PMID: 30262056.
    Citations:    Fields:    Translation:AnimalsCells
  14. Tang TT, Li YY, Li JJ, Wang K, Han Y, Dong WY, Zhu ZF, Xia N, Nie SF, Zhang M, Zeng ZP, Lv BJ, Jiao J, Liu H, Xian ZS, Yang XP, Hu Y, Liao YH, Wang Q, Tu X, Mallat Z, Huang Y, Shi GP, Cheng X. Liver-heart crosstalk controls IL-22 activity in cardiac protection after myocardial infarction. Theranostics. 2018; 8(16):4552-4562. PMID: 30214638.
    Citations:    Fields:    
  15. Liu CL, Guo J, Zhang X, Sukhova GK, Libby P, Shi GP. Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials. Nat Rev Cardiol. 2018 Jun; 15(6):351-370. PMID: 29679024.
    Citations: 1     Fields:    
  16. Ma T, Lu D, Zhu YS, Chu XF, Wang Y, Shi GP, Wang ZD, Yu L, Jiang XY, Wang XF. ACTN3 genotype and physical function and frailty in an elderly Chinese population: the Rugao Longevity and Ageing Study. Age Ageing. 2018 May 01; 47(3):416-422. PMID: 29447359.
    Citations:    Fields:    
  17. Ma T, Cai J, Zhu YS, Chu XF, Wang Y, Shi GP, Wang ZD, Yao S, Wang XF, Jiang XY. Association between a frailty index based on common laboratory tests and QTc prolongation in older adults: the Rugao Longevity and Ageing Study. Clin Interv Aging. 2018; 13:797-804. PMID: 29731619.
    Citations:    Fields:    Translation:Humans
  18. Xue SF, Chen ZH, Han XY, Lin ZY, Wang QX, Zhang M, Shi G. DNA Encountering Terbium(III): A Smart "Chemical Nose/Tongue" for Large-Scale Time-Gated Luminescent and Lifetime-Based Sensing. Anal Chem. 2018 03 06; 90(5):3443-3451. PMID: 29433302.
    Citations:    Fields:    
  19. Xue SF, Zhang JF, Chen ZH, Han XY, Zhang M, Shi G. Multifunctional fluorescent sensing of chemical and physical stimuli using smart riboflavin-5'-phosphate/Eu3+ coordination polymers. Anal Chim Acta. 2018 Jul 05; 1012:74-81. PMID: 29475476.
    Citations:    Fields:    
  20. Ogasawara S, Cheng XW, Inoue A, Hu L, Piao L, Yu C, Goto H, Xu W, Zhao G, Lei Y, Yang G, Kimura K, Umegaki H, Shi GP, Kuzuya M. Cathepsin K activity controls cardiotoxin-induced skeletal muscle repair in mice. J Cachexia Sarcopenia Muscle. 2018 02; 9(1):160-175. PMID: 29058826.
    Citations:    Fields:    Translation:Animals
  21. Libby P, Sukhova GK, Ozaki CK, Shi GP. Tilting at the tilted protease balance in arterial aneurysmal disease. Cardiovasc Res. 2017 09 01; 113(11):1279-1281. PMID: 28859304.
    Citations:    Fields:    Translation:HumansCells
  22. Zhu Z, Liang L, Zhang R, Wei Y, Su L, Tejera P, Guo Y, Wang Z, Lu Q, Baccarelli AA, Zhu X, Bajwa EK, Taylor Thompson B, Shi GP, Christiani DC. Whole blood microRNA markers are associated with acute respiratory distress syndrome. Intensive Care Med Exp. 2017 Aug 30; 5(1):38. PMID: 28856588.
  23. Jin DY, Liu CL, Tang JN, Zhu ZZ, Xuan XX, Zhu XD, Wang YZ, Zhang TX, Shen DL, Wang XF, Shi GP, Zhang JY. Interleukin-18, matrix metalloproteinase-22 and -29 are independent risk factors of human coronary heart disease. J Zhejiang Univ Sci B. 2017 Aug.; 18(8):685-695. PMID: 28786243.
    Citations:    Fields:    
  24. Ouyang Q, Wu J, Jiang Z, Zhao J, Wang R, Lou A, Zhu D, Shi GP, Yang M. Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients. Cell Physiol Biochem. 2017; 42(2):651-659. PMID: 28618429.
    Citations: 7     Fields:    Translation:HumansCells
  25. Qi YX, Qu ZB, Wang QX, Zhang M, Shi G. Nanomolar sensitive colorimetric assay for Mn2+ using cysteic acid-capped silver nanoparticles and theoretical investigation of its sensing mechanism. Anal Chim Acta. 2017 Aug 08; 980:65-71. PMID: 28622805.
    Citations:    Fields:    
  26. Liu CL, Santos MM, Fernandes C, Liao M, Iamarene K, Zhang JY, Sukhova GK, Shi GP. Toll-like receptor 7 deficiency protects apolipoprotein E-deficient mice from diet-induced atherosclerosis. Sci Rep. 2017 04 12; 7(1):847. PMID: 28405010.
    Citations:    Fields:    Translation:AnimalsCells
  27. Wang QX, Xue SF, Chen ZH, Ma SH, Zhang S, Shi G, Zhang M. Dual lanthanide-doped complexes: the development of a time-resolved ratiometric fluorescent probe for anthrax biomarker and a paper-based visual sensor. Biosens Bioelectron. 2017 Aug 15; 94:388-393. PMID: 28324858.
    Citations: 1     Fields:    Translation:Humans
  28. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Zhang L, Kyttaris VC, Tsokos GC, Stillman IE, Ichimura T, Bonventre JV, Libby P, Shi GP. CD74 Deficiency Mitigates Systemic Lupus Erythematosus-like Autoimmunity and Pathological Findings in Mice. J Immunol. 2017 04 01; 198(7):2568-2577. PMID: 28219888.
    Citations:    Fields:    Translation:AnimalsCells
  29. Zhou Y, Chen H, Liu L, Yu X, Sukhova GK, Yang M, Kyttaris VC, Stillman IE, Gelb B, Libby P, Tsokos GC, Shi GP. Cathepsin K Deficiency Ameliorates Systemic Lupus Erythematosus-like Manifestations in Faslpr Mice. J Immunol. 2017 03 01; 198(5):1846-1854. PMID: 28093526.
    Citations: 1     Fields:    Translation:AnimalsCells
  30. Shi GP, Bot I, Kovanen PT. Reply: The complexity of substance P-mediated mast cell activation. Nat Rev Cardiol. 2017 02; 14(2):124. PMID: 28054578.
    Citations:    Fields:    
  31. Yan X, Wu C, Chen T, Santos MM, Liu CL, Yang C, Zhang L, Ren J, Liao S, Guo H, Sukhova GK, Shi GP. Cathepsin S inhibition changes regulatory T-cell activity in regulating bladder cancer and immune cell proliferation and apoptosis. Mol Immunol. 2017 02; 82:66-74. PMID: 28033540.
    Citations: 1     Fields:    Translation:AnimalsCells
  32. Satyam A, Kannan L, Matsumoto N, Geha M, Lapchak PH, Bosse R, Shi GP, Dalle Lucca JJ, Tsokos MG, Tsokos GC. Intracellular Activation of Complement 3 Is Responsible for Intestinal Tissue Damage during Mesenteric Ischemia. J Immunol. 2017 01 15; 198(2):788-797. PMID: 27913632.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  33. Donners MM, Bai L, Lutgens SP, Wijnands E, Johnson J, Schurgers LJ, Liu CL, Daemen MJ, Cleutjens KB, Shi GP, Biessen EA, Heeneman S. Cathepsin K Deficiency Prevents the Aggravated Vascular Remodeling Response to Flow Cessation in ApoE-/- Mice. PLoS One. 2016; 11(9):e0162595. PMID: 27636705.
    Citations: 1     Fields:    Translation:AnimalsCells
  34. Wu H, Cheng XW, Hu L, Takeshita K, Hu C, Du Q, Li X, Zhu E, Huang Z, Yisireyili M, Zhao G, Piao L, Inoue A, Jiang H, Lei Y, Zhang X, Liu S, Dai Q, Kuzuya M, Shi GP, Murohara T. Cathepsin S Activity Controls Injury-Related Vascular Repair in Mice via the TLR2-Mediated p38MAPK and PI3K-Akt/p-HDAC6 Signaling Pathway. Arterioscler Thromb Vasc Biol. 2016 08; 36(8):1549-57. PMID: 27365406.
    Citations: 6     Fields:    Translation:AnimalsCells
  35. Xue SF, Lu LF, Wang QX, Zhang S, Zhang M, Shi G. An integrated logic system for time-resolved fluorescent "turn-on" detection of cysteine and histidine base on terbium (III) coordination polymer-copper (II) ensemble. Talanta. 2016 Sep 01; 158:208-213. PMID: 27343597.
    Citations:    Fields:    Translation:Animals
  36. Yang D, Jin C, Ma H, Huang M, Shi GP, Wang J, Xiang M. EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease. Angiogenesis. 2016 07; 19(3):297-309. PMID: 27216867.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  37. Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Rittié L, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest. 2016 05 02; 126(5):2012. PMID: 27135882.
    Citations: 2     Fields:    
  38. Zhang C, van der Voort D, Shi H, Zhang R, Qing Y, Hiraoka S, Takemoto M, Yokote K, Moxon JV, Norman P, Rittié L, Kuivaniemi H, Atkins GB, Gerson SL, Shi GP, Golledge J, Dong N, Perbal B, Prosdocimo DA, Lin Z. Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest. 2016 Apr 01; 126(4):1282-99. PMID: 26974158.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  39. Liu CL, Wemmelund H, Wang Y, Liao M, Lindholt JS, Johnsen SP, Vestergaard H, Fernandes C, Sukhova GK, Cheng X, Zhang JY, Yang C, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture. Arterioscler Thromb Vasc Biol. 2016 Mar; 36(3):570-8. PMID: 26868210.
    Citations: 3     Fields:    Translation:Humans
  40. Liu CL, Wang Y, Liao M, Santos MM, Fernandes C, Sukhova GK, Zhang JY, Cheng X, Yang C, Huang X, Levy B, Libby P, Wu G, Shi GP. Allergic lung inflammation promotes atherosclerosis in apolipoprotein E-deficient mice. Transl Res. 2016 May; 171:1-16. PMID: 26898714.
    Citations:    Fields:    Translation:AnimalsCells
  41. Liu CL, Wang Y, Liao M, Wemmelund H, Ren J, Fernandes C, Zhou Y, Sukhova GK, Lindholt JS, Johnsen SP, Zhang JY, Cheng X, Huang X, Daugherty A, Levy BD, Libby P, Shi GP. Allergic Lung Inflammation Aggravates Angiotensin II-Induced Abdominal Aortic Aneurysms in Mice. Arterioscler Thromb Vasc Biol. 2016 Jan; 36(1):69-77. PMID: 26543094.
    Citations: 8     Fields:    Translation:AnimalsCells
  42. Zhou Y, Yu X, Chen H, Sjöberg S, Roux J, Zhang L, Ivoulsou AH, Bensaid F, Liu CL, Liu J, Tordjman J, Clement K, Lee CH, Hotamisligil GS, Libby P, Shi GP. Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages. Cell Metab. 2015 Dec 01; 22(6):1045-58. PMID: 26481668.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  43. Liu CL, Zhang JY, Shi GP. Interaction between allergic asthma and atherosclerosis. Transl Res. 2016 08; 174:5-22. PMID: 26608212.
    Citations: 1     Fields:    Translation:HumansCells
  44. Lee YJ, Liu C, Liao M, Sukhova GK, Shirakawa J, Abdennour M, Iamarene K, Andre S, Inouye K, Clement K, Kulkarni RN, Banks AS, Libby P, Shi GP. Deficiency of Fc?R1 Increases Body Weight Gain but Improves Glucose Tolerance in Diet-Induced Obese Mice. Endocrinology. 2015 Nov; 156(11):4047-58. PMID: 26295369.
    Citations:    Fields:    Translation:HumansAnimalsCells
  45. Tang T, Deng J, Zhang M, Shi G, Zhou T. Quantum dot-DNA aptamer conjugates coupled with capillary electrophoresis: A universal strategy for ratiometric detection of organophosphorus pesticides. Talanta. 2016; 146:55-61. PMID: 26695234.
    Citations: 4     Fields:    Translation:Cells
  46. Shi GP, Bot I, Kovanen PT. Mast cells in human and experimental cardiometabolic diseases. Nat Rev Cardiol. 2015 Nov; 12(11):643-58. PMID: 26259935.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  47. Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015 Jul; 21(7):820-6. PMID: 26099046.
    Citations: 9     Fields:    Translation:AnimalsCells
  48. Yan X, Zhang M, Chen X, Wei W, Yang R, Yang Y, Gan W, Guo H, Wang Y, Shi GP. Image-guided percutaneous renal cryoablation for stage 1 renal cell carcinoma with high surgical risk. World J Surg Oncol. 2015 Jun 10; 13:200. PMID: 26059547.
    Citations: 2     Fields:    Translation:Humans
  49. Xu J, Lu X, Shi GP. Vasa vasorum in atherosclerosis and clinical significance. Int J Mol Sci. 2015 May 20; 16(5):11574-608. PMID: 26006236.
    Citations: 7     Fields:    Translation:HumansAnimals
  50. Jiang Y, Tang T, Cao Z, Shi G, Zhou T. Determination of three estrogens and bisphenol A by functional ionic liquid dispersive liquid-phase microextraction coupled with ultra-high performance liquid chromatography and ultraviolet detection. J Sep Sci. 2015 Jun; 38(12):2158-66. PMID: 25864862.
    Citations:    Fields:    Translation:Cells
  51. Xia N, Jiao J, Tang TT, Lv BJ, Lu YZ, Wang KJ, Zhu ZF, Mao XB, Nie SF, Wang Q, Tu X, Xiao H, Liao YH, Shi GP, Cheng X. Activated regulatory T-cells attenuate myocardial ischaemia/reperfusion injury through a CD39-dependent mechanism. Clin Sci (Lond). 2015 May 01; 128(10):679-93. PMID: 25558978.
    Citations: 5     Fields:    Translation:AnimalsCells
  52. Liao M, Liu CL, Lv BJ, Zhang JY, Cheng L, Cheng X, Lindholt JS, Rasmussen LM, Shi GP. Plasma cytokine levels and risks of abdominal aortic aneurysms: A population-based prospective cohort study. Ann Med. 2015 May; 47(3):245-52. PMID: 25856542.
    Citations: 2     Fields:    Translation:Humans
  53. Zhou Y, Wu W, Lindholt JS, Sukhova GK, Libby P, Yu X, Shi GP. Regulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms. Cardiovasc Res. 2015 Jul 01; 107(1):98-107. PMID: 25824145.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  54. Zhu ZF, Tang TT, Dong WY, Li YY, Xia N, Zhang WC, Zhou SF, Yuan J, Liao MY, Li JJ, Jiao J, Nie SF, Wang Q, Tu X, Xu CQ, Liao YH, Shi GP, Cheng X. Defective circulating CD4+LAP+ regulatory T cells in patients with dilated cardiomyopathy. J Leukoc Biol. 2015 Apr; 97(4):797-805. PMID: 25722319.
    Citations: 4     Fields:    Translation:HumansCells
  55. Hua Y, Robinson TJ, Cao Y, Shi GP, Ren J, Nair S. Cathepsin K knockout alleviates aging-induced cardiac dysfunction. Aging Cell. 2015 Jun; 14(3):345-51. PMID: 25692548.
    Citations: 8     Fields:    Translation:AnimalsCells
  56. Yu Y, Sun X, Tang D, Li C, Zhang L, Nie D, Yin X, Shi G. Gelsolin bound ß-amyloid peptides(1-40/1-42): electrochemical evaluation of levels of soluble peptide associated with Alzheimer's disease. Biosens Bioelectron. 2015 Jun 15; 68:115-121. PMID: 25562737.
    Citations: 4     Fields:    Translation:HumansAnimals
  57. Wu H, Cheng XW, Hu L, Hao CN, Hayashi M, Takeshita K, Hamrah MS, Shi GP, Kuzuya M, Murohara T. Renin inhibition reduces atherosclerotic plaque neovessel formation and regresses advanced atherosclerotic plaques. Atherosclerosis. 2014 Dec; 237(2):739-47. PMID: 25463114.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  58. Yu Y, Zhang L, Li C, Sun X, Tang D, Shi G. A method for evaluating the level of soluble ß-amyloid(1-40/1-42) in Alzheimer's disease based on the binding of gelsolin to ß-amyloid peptides. Angew Chem Int Ed Engl. 2014 Nov 17; 53(47):12832-5. PMID: 25244702.
    Citations: 2     Fields:    Translation:AnimalsCells
  59. Bot I, Shi GP, Kovanen PT. Mast cells as effectors in atherosclerosis. Arterioscler Thromb Vasc Biol. 2015 Feb; 35(2):265-71. PMID: 25104798.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  60. Wang J, Sjöberg S, Tang TT, Oörni K, Wu W, Liu C, Secco B, Tia V, Sukhova GK, Fernandes C, Lesner A, Kovanen PT, Libby P, Cheng X, Shi GP. Cathepsin G activity lowers plasma LDL and reduces atherosclerosis. Biochim Biophys Acta. 2014 Nov; 1842(11):2174-83. PMID: 25092171.
    Citations: 5     Fields:    
  61. Xu J, Shi GP. Vascular wall extracellular matrix proteins and vascular diseases. Biochim Biophys Acta. 2014 Nov; 1842(11):2106-2119. PMID: 25045854.
    Citations: 22     Fields:    
  62. Wang J, Sukhova GK, Liu J, Ozaki K, Lesner A, Libby P, Kovanen PT, Shi GP. Cathepsin G deficiency reduces periaortic calcium chloride injury-induced abdominal aortic aneurysms in mice. J Vasc Surg. 2015 Dec; 62(6):1615-24. PMID: 25037606.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  63. Wang J, Lindholt JS, Sukhova GK, Shi MA, Xia M, Chen H, Xiang M, He A, Wang Y, Xiong N, Libby P, Wang JA, Shi GP. IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Mol Med. 2014 Jul; 6(7):952-69. PMID: 24963147.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  64. Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF, Zhang WC, Lv BJ, Xiao H, Wang Q, Tu X, Liao YH, Shi GP, Cheng X. IL-17A promotes ventricular remodeling after myocardial infarction. J Mol Med (Berl). 2014 Oct; 92(10):1105-16. PMID: 24965614.
    Citations: 11     Fields:    Translation:AnimalsCells
  65. Jiang H, Cheng XW, Shi GP, Hu L, Inoue A, Yamamura Y, Wu H, Takeshita K, Li X, Huang Z, Song H, Asai M, Hao CN, Unno K, Koike T, Oshida Y, Okumura K, Murohara T, Kuzuya M. Cathepsin K-mediated Notch1 activation contributes to neovascularization in response to hypoxia. Nat Commun. 2014 Jun 04; 5:3838. PMID: 24894568.
    Citations: 18     Fields:    Translation:AnimalsCells
  66. Lafarge JC, Pini M, Pelloux V, Orasanu G, Hartmann G, Venteclef N, Sulpice T, Shi GP, Clément K, Guerre-Millo M. Cathepsin S inhibition lowers blood glucose levels in mice. Diabetologia. 2014 Aug; 57(8):1674-83. PMID: 24891017.
    Citations: 2     Fields:    Translation:Animals
  67. Zhou Y, Zhou T, Zhang M, Shi G. A DNA-scaffolded silver nanocluster/Cu²? ensemble as a turn-on fluorescent probe for histidine. Analyst. 2014 Jun 21; 139(12):3122-6. PMID: 24788120.
    Citations: 1     Fields:    
  68. Chen G, Wang X, Severo MS, Sakhon OS, Sohail M, Brown LJ, Sircar M, Snyder GA, Sundberg EJ, Ulland TK, Olivier AK, Andersen JF, Zhou Y, Shi GP, Sutterwala FS, Kotsyfakis M, Pedra JH. The tick salivary protein sialostatin L2 inhibits caspase-1-mediated inflammation during Anaplasma phagocytophilum infection. Infect Immun. 2014 Jun; 82(6):2553-64. PMID: 24686067.
    Citations: 12     Fields:    Translation:AnimalsCells
  69. Fujita M, Cheng XW, Inden Y, Shimano M, Yoshida N, Inoue A, Yamamoto T, Takeshita K, Kyo S, Taguchi N, Shi GP, Kuzuya M, Okumura K, Murohara T. Mechanisms with clinical implications for atrial fibrillation-associated remodeling: cathepsin K expression, regulation, and therapeutic target and biomarker. J Am Heart Assoc. 2013 Dec 16; 2(6):e000503. PMID: 24342995.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  70. Hu L, Cheng XW, Song H, Inoue A, Jiang H, Li X, Shi GP, Kozawa E, Okumura K, Kuzuya M. Cathepsin K activity controls injury-related vascular repair in mice. Hypertension. 2014 Mar; 63(3):607-15. PMID: 24343118.
    Citations: 9     Fields:    Translation:Animals
  71. Xu N, Zhang YY, Lin Y, Bao B, Zheng L, Shi GP, Liu J. Increased levels of lysosomal cysteinyl cathepsins in human varicose veins: a histology study. Thromb Haemost. 2014 Feb; 111(2):333-44. PMID: 24154706.
    Citations: 3     Fields:    Translation:HumansCells
  72. Zhou Y, Qu ZB, Zeng Y, Zhou T, Shi G. A novel composite of graphene quantum dots and molecularly imprinted polymer for fluorescent detection of paranitrophenol. Biosens Bioelectron. 2014 Feb 15; 52:317-23. PMID: 24080211.
    Citations: 3     Fields:    
  73. Lv BJ, Lindholt JS, Wang J, Cheng X, Shi GP. Plasma levels of cathepsins L, K, and V and risks of abdominal aortic aneurysms: a randomized population-based study. Atherosclerosis. 2013 Sep; 230(1):100-105. PMID: 23958260.
    Citations: 11     Fields:    Translation:Humans
  74. Chen H, Wang J, Xiang MX, Lin Y, He A, Jin CN, Guan J, Sukhova GK, Libby P, Wang JA, Shi GP. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovasc Res. 2013 Oct 01; 100(1):84-94. PMID: 23771947.
    Citations: 9     Fields:    Translation:AnimalsCells
  75. Wang J, Sjöberg S, Tia V, Secco B, Chen H, Yang M, Sukhova GK, Shi GP. Pharmaceutical stabilization of mast cells attenuates experimental atherogenesis in low-density lipoprotein receptor-deficient mice. Atherosclerosis. 2013 Aug; 229(2):304-9. PMID: 23880180.
    Citations: 6     Fields:    Translation:AnimalsCells
  76. Koskinas KC, Sukhova GK, Baker AB, Papafaklis MI, Chatzizisis YS, Coskun AU, Quillard T, Jonas M, Maynard C, Antoniadis AP, Shi GP, Libby P, Edelman ER, Feldman CL, Stone PH. Thin-capped atheromata with reduced collagen content in pigs develop in coronary arterial regions exposed to persistently low endothelial shear stress. Arterioscler Thromb Vasc Biol. 2013 Jul; 33(7):1494-504. PMID: 23640495.
    Citations: 13     Fields:    Translation:AnimalsCells
  77. Shi GP, Lindholt JS. Mast cells in abdominal aortic aneurysms. Curr Vasc Pharmacol. 2013 May; 11(3):314-26. PMID: 22724485.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  78. Hua Y, Xu X, Shi GP, Chicco AJ, Ren J, Nair S. Cathepsin K knockout alleviates pressure overload-induced cardiac hypertrophy. Hypertension. 2013 Jun; 61(6):1184-92. PMID: 23529168.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  79. Zeng Y, Zhou Y, Kong L, Zhou T, Shi G. A novel composite of SiO2-coated graphene oxide and molecularly imprinted polymers for electrochemical sensing dopamine. Biosens Bioelectron. 2013 Jul 15; 45:25-33. PMID: 23454339.
    Citations: 2     Fields:    Translation:Humans
  80. Qin Y, Cao X, Yang Y, Shi GP. Cysteine protease cathepsins and matrix metalloproteinases in the development of abdominal aortic aneurysms. Future Cardiol. 2013 Jan; 9(1):89-103. PMID: 23259477.
    Citations: 10     Fields:    Translation:HumansAnimals
  81. He A, Shi GP. Mast cell chymase and tryptase as targets for cardiovascular and metabolic diseases. Curr Pharm Des. 2013; 19(6):1114-25. PMID: 23016684.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  82. Shao X, Gu H, Wang Z, Chai X, Tian Y, Shi G. Highly selective electrochemical strategy for monitoring of cerebral Cu2+ based on a carbon Dot-TPEA hybridized surface. Anal Chem. 2013 Jan 02; 85(1):418-25. PMID: 23214718.
    Citations: 1     Fields:    Translation:Animals
  83. Li P, Zhao W, Wang X, Shi G, Zhou T. Stacking and simultaneous determination of estrogens in water samples by CE with electrochemical detection. J Sep Sci. 2013 Jan; 36(2):334-40. PMID: 23255353.
    Citations:    Fields:    
  84. Wang Z, Liu D, Gu H, Zhu A, Tian Y, Shi G. NTA-modified carbon electrode as a general relaying substrate to facilitate electron transfer of SOD: application to in vivo monitoring of O2(-) in a rat brain. Biosens Bioelectron. 2013 May 15; 43:101-7. PMID: 23291216.
    Citations: 1     Fields:    Translation:AnimalsCells
  85. Wang Z, Zhang H, Shen XH, Jin KL, Ye GF, Qiu W, Qian L, Li B, Zhang YH, Shi GP. Immunoglobulin E and mast cell proteases are potential risk factors of impaired fasting glucose and impaired glucose tolerance in humans. Ann Med. 2013 May; 45(3):220-9. PMID: 23110545.
    Citations: 10     Fields:    Translation:HumansCells
  86. Hua Y, Zhang Y, Dolence J, Shi GP, Ren J, Nair S. Cathepsin K knockout mitigates high-fat diet-induced cardiac hypertrophy and contractile dysfunction. Diabetes. 2013 Feb; 62(2):498-509. PMID: 23069627.
    Citations: 22     Fields:    Translation:AnimalsCells
  87. Cheng X, Wang J, Xia N, Yan XX, Tang TT, Chen H, Zhang HJ, Liu J, Kong W, Sjöberg S, Folco E, Libby P, Liao YH, Shi GP. A guanidine-rich regulatory oligodeoxynucleotide improves type-2 diabetes in obese mice by blocking T-cell differentiation. EMBO Mol Med. 2012 Oct; 4(10):1112-25. PMID: 23027613.
    Citations: 4     Fields:    Translation:AnimalsCells
  88. Wang Y, Shi GP. Mast cell chymase and tryptase in abdominal aortic aneurysm formation. Trends Cardiovasc Med. 2012 Aug; 22(6):150-5. PMID: 22902093.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  89. Zhang J, Chen H, Liu L, Sun J, Shi MA, Sukhova GK, Shi GP. Chemokine (C-C motif) receptor 2 mediates mast cell migration to abdominal aortic aneurysm lesions in mice. Cardiovasc Res. 2012 Dec 01; 96(3):543-51. PMID: 22871590.
    Citations: 5     Fields:    Translation:AnimalsCells
  90. Qin Y, Cao X, Guo J, Zhang Y, Pan L, Zhang H, Li H, Tang C, Du J, Shi GP. Deficiency of cathepsin S attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. Cardiovasc Res. 2012 Dec 01; 96(3):401-10. PMID: 22871592.
    Citations: 20     Fields:    Translation:AnimalsCells
  91. Lv BJ, Lindholt JS, Cheng X, Wang J, Shi GP. Plasma cathepsin S and cystatin C levels and risk of abdominal aortic aneurysm: a randomized population-based study. PLoS One. 2012; 7(7):e41813. PMID: 22844527.
    Citations: 16     Fields:    Translation:Humans
  92. Elmasri H, Ghelfi E, Yu CW, Traphagen S, Cernadas M, Cao H, Shi GP, Plutzky J, Sahin M, Hotamisligil G, Cataltepe S. Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway. Angiogenesis. 2012 Sep; 15(3):457-68. PMID: 22562362.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  93. Cheng XW, Shi GP, Kuzuya M, Sasaki T, Okumura K, Murohara T. Role for cysteine protease cathepsins in heart disease: focus on biology and mechanisms with clinical implication. Circulation. 2012 Mar 27; 125(12):1551-62. PMID: 22451605.
    Citations: 32     Fields:    Translation:HumansAnimals
  94. Liu L, Shi GP. CD31: beyond a marker for endothelial cells. Cardiovasc Res. 2012 Apr 01; 94(1):3-5. PMID: 22379038.
    Citations: 12     Fields:    Translation:Animals
  95. Kozawa E, Nishida Y, Cheng XW, Urakawa H, Arai E, Futamura N, Shi GP, Kuzuya M, Hu L, Sasaki T, Ishiguro N. Osteoarthritic change is delayed in a Ctsk-knockout mouse model of osteoarthritis. Arthritis Rheum. 2012 Feb; 64(2):454-64. PMID: 21968827.
    Citations: 16     Fields:    Translation:AnimalsCells
  96. Shi MA, Shi GP. Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans. Front Immunol. 2012; 3:7. PMID: 22566893.
    Citations: 10     
  97. Liao YH, Xia N, Zhou SF, Tang TT, Yan XX, Lv BJ, Nie SF, Wang J, Iwakura Y, Xiao H, Yuan J, Jevallee H, Wei F, Shi GP, Cheng X. Interleukin-17A contributes to myocardial ischemia/reperfusion injury by regulating cardiomyocyte apoptosis and neutrophil infiltration. J Am Coll Cardiol. 2012 Jan 24; 59(4):420-9. PMID: 22261166.
    Citations: 51     Fields:    Translation:AnimalsCells
  98. Xu JM, Shi GP. Emerging role of mast cells and macrophages in cardiovascular and metabolic diseases. Endocr Rev. 2012 Feb; 33(1):71-108. PMID: 22240242.
    Citations: 31     Fields:    Translation:HumansCells
  99. Wang Z, Zhang H, Shen XH, Jin KL, Ye GF, Qian L, Li B, Zhang YH, Shi GP. Immunoglobulin E and mast cell proteases are potential risk factors of human pre-diabetes and diabetes mellitus. PLoS One. 2011; 6(12):e28962. PMID: 22194960.
    Citations: 13     Fields:    Translation:HumansCells
  100. Xia M, Guerra N, Sukhova GK, Yang K, Miller CK, Shi GP, Raulet DH, Xiong N. Immune activation resulting from NKG2D/ligand interaction promotes atherosclerosis. Circulation. 2011 Dec 20; 124(25):2933-43. PMID: 22104546.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  101. Zhao X, Zhou Y, Song H, Guan L, Zheng G, Jin Z, Shi D, Li Y, Guo Y, Shi GP, Cheng XW. Comparison of bypass surgery with drug-eluting stents in diabetic patients with left main coronary stenosis. Yonsei Med J. 2011 Nov; 52(6):923-32. PMID: 22028155.
    Citations: 1     Fields:    Translation:Humans
  102. Wang J, Shi GP. Mast cell stabilization: novel medication for obesity and diabetes. Diabetes Metab Res Rev. 2011 Nov; 27(8):919-24. PMID: 22069285.
    Citations: 11     Fields:    Translation:AnimalsCells
  103. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xiang M, Wang J, Peters C, Reinheckel T, Shi GP. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2011 Nov; 31(11):2500-8. PMID: 21868704.
    Citations: 26     Fields:    Translation:AnimalsCells
  104. Tang TT, Zhu ZF, Wang J, Zhang WC, Tu X, Xiao H, Du XL, Xia JH, Dong NG, Su W, Xia N, Yan XX, Nie SF, Liu J, Zhou SF, Yao R, Xie JJ, Jevallee H, Wang X, Liao MY, Shi GP, Fu M, Liao YH, Cheng X. Correction: impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure. PLoS One. 2011; 6(9). PMID: 21977222.
  105. Tang TT, Zhu ZF, Wang J, Zhang WC, Tu X, Xiao H, Du XL, Xia JH, Dong NG, Su W, Xia N, Yan XX, Yan XX, Nie SF, Liu J, Zhou SF, Yao R, Xie JJ, Jevallee H, Wang X, Liao MY, Shi GP, Fu M, Liao YH, Cheng X. Impaired thymic export and apoptosis contribute to regulatory T-cell defects in patients with chronic heart failure. PLoS One. 2011; 6(9):e24272. PMID: 21935395.
    Citations: 6     Fields:    Translation:HumansCells
  106. Yu Y, Sun Q, Liu X, Wu H, Zhou T, Shi G. Size-controllable gold-platinum alloy nanoparticles on nine functionalized ionic-liquid surfaces and their application as electrocatalysts for hydrogen peroxide reduction. Chemistry. 2011 Sep 26; 17(40):11314-23. PMID: 21853478.
    Citations: 3     Fields:    
  107. Wang J, Cheng X, Xiang MX, Alanne-Kinnunen M, Wang JA, Chen H, He A, Sun X, Lin Y, Tang TT, Tu X, Sjöberg S, Sukhova GK, Liao YH, Conrad DH, Yu L, Kawakami T, Kovanen PT, Libby P, Shi GP. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe-/- mice. J Clin Invest. 2011 Sep; 121(9):3564-77. PMID: 21821913.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  108. Sun J, Sukhova GK, Zhang J, Chen H, Sjöberg S, Libby P, Xia M, Xiong N, Gelb BD, Shi GP. Cathepsin K deficiency reduces elastase perfusion-induced abdominal aortic aneurysms in mice. Arterioscler Thromb Vasc Biol. 2012 Jan; 32(1):15-23. PMID: 21817099.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  109. Sjöberg S, Shi GP. Cysteine Protease Cathepsins in Atherosclerosis and Abdominal Aortic Aneurysm. Clin Rev Bone Miner Metab. 2011 Jun 01; 9(2):138-147. PMID: 22505840.
    Citations: 7     
  110. Qin Y, Shi GP. Cysteinyl cathepsins and mast cell proteases in the pathogenesis and therapeutics of cardiovascular diseases. Pharmacol Ther. 2011 Sep; 131(3):338-50. PMID: 21605595.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  111. Zhang J, Sun J, Lindholt JS, Sukhova GK, Sinnamon M, Stevens RL, Adachi R, Libby P, Thompson RW, Shi GP. Mast cell tryptase deficiency attenuates mouse abdominal aortic aneurysm formation. Circ Res. 2011 May 27; 108(11):1316-27. PMID: 21493897.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  112. Cheng XW, Song H, Sasaki T, Hu L, Inoue A, Bando YK, Shi GP, Kuzuya M, Okumura K, Murohara T. Angiotensin type 1 receptor blocker reduces intimal neovascularization and plaque growth in apolipoprotein E-deficient mice. Hypertension. 2011 May; 57(5):981-9. PMID: 21464389.
    Citations: 18     Fields:    Translation:Animals
  113. Tang TT, Song Y, Ding YJ, Liao YH, Yu X, Du R, Xiao H, Yuan J, Zhou ZH, Liao MY, Yao R, Jevallee H, Shi GP, Cheng X. Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis. J Lipid Res. 2011 May; 52(5):1023-32. PMID: 21368320.
    Citations: 22     Fields:    Translation:HumansCells
  114. Cheng XW, Kuzuya M, Sasaki T, Inoue A, Hu L, Song H, Huang Z, Li P, Takeshita K, Hirashiki A, Sato K, Shi GP, Okumura K, Murohara T. Inhibition of mineralocorticoid receptor is a renoprotective effect of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitor pitavastatin. J Hypertens. 2011 Mar; 29(3):542-52. PMID: 21119529.
    Citations: 11     Fields:    Translation:AnimalsCells
  115. Urbonaviciene G, Shi GP, Urbonavicius S, Henneberg EW, Lindholt JS. Higher cystatin C level predicts long-term mortality in patients with peripheral arterial disease. Atherosclerosis. 2011 Jun; 216(2):440-5. PMID: 21388623.
    Citations: 10     Fields:    Translation:Humans
  116. Chatzizisis YS, Baker AB, Sukhova GK, Koskinas KC, Papafaklis MI, Beigel R, Jonas M, Coskun AU, Stone BV, Maynard C, Shi GP, Libby P, Feldman CL, Edelman ER, Stone PH. Augmented expression and activity of extracellular matrix-degrading enzymes in regions of low endothelial shear stress colocalize with coronary atheromata with thin fibrous caps in pigs. Circulation. 2011 Feb 15; 123(6):621-30. PMID: 21282495.
    Citations: 29     Fields:    Translation:AnimalsCells
  117. Xiang M, Sun J, Lin Y, Zhang J, Chen H, Yang D, Wang J, Shi GP. Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis. 2011 Apr; 215(2):494-9. PMID: 21324464.
    Citations: 13     Fields:    Translation:Humans
  118. Zhang J, Alcaide P, Liu L, Sun J, He A, Luscinskas FW, Shi GP. Regulation of endothelial cell adhesion molecule expression by mast cells, macrophages, and neutrophils. PLoS One. 2011 Jan 14; 6(1):e14525. PMID: 21264293.
    Citations: 36     Fields:    Translation:AnimalsCells
  119. Zhang J, Shi GP. Mast cells and metabolic syndrome. Biochim Biophys Acta. 2012 Jan; 1822(1):14-20. PMID: 21185370.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  120. Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P. Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol. 2011 Feb; 31(2):261-9. PMID: 21088251.
    Citations: 19     Fields:    Translation:AnimalsCells
  121. Yu W, Liu J, Shi MA, Wang J, Xiang M, Kitamoto S, Wang B, Sukhova GK, Murphy GF, Orasanu G, Grubb A, Shi GP. Cystatin C deficiency promotes epidermal dysplasia in K14-HPV16 transgenic mice. PLoS One. 2010 Nov 15; 5(11):e13973. PMID: 21085595.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  122. Shi MA, Shi GP. Intracellular delivery strategies for microRNAs and potential therapies for human cardiovascular diseases. Sci Signal. 2010 Nov 02; 3(146):pe40. PMID: 21045204.
    Citations: 4     Fields:    Translation:HumansAnimals
  123. Nie D, Li P, Zhang D, Zhou T, Liang Y, Shi G. Simultaneous determination of nitroaromatic compounds in water using capillary electrophoresis with amperometric detection on an electrode modified with a mesoporous nano-structured carbon material. Electrophoresis. 2010 Sep; 31(17):2981-8. PMID: 20836147.
    Citations: 1     Fields:    Translation:PHPublic Health
  124. Tang EH, Shimizu K, Christen T, Rocha VZ, Shvartz E, Tesmenitsky Y, Sukhova G, Shi GP, Libby P. Lack of EP4 receptors on bone marrow-derived cells enhances inflammation in atherosclerotic lesions. Cardiovasc Res. 2011 Jan 01; 89(1):234-43. PMID: 20736236.
    Citations: 16     Fields:    Translation:AnimalsCells
  125. Sun J, Hartvigsen K, Chou MY, Zhang Y, Sukhova GK, Zhang J, Lopez-Ilasaca M, Diehl CJ, Yakov N, Harats D, George J, Witztum JL, Libby P, Ploegh H, Shi GP. Deficiency of antigen-presenting cell invariant chain reduces atherosclerosis in mice. Circulation. 2010 Aug 24; 122(8):808-20. PMID: 20697023.
    Citations: 30     Fields:    Translation:AnimalsCellsPHPublic Health
  126. Cheng XW, Kuzuya M, Kim W, Song H, Hu L, Inoue A, Nakamura K, Di Q, Sasaki T, Tsuzuki M, Shi GP, Okumura K, Murohara T. Exercise training stimulates ischemia-induced neovascularization via phosphatidylinositol 3-kinase/Akt-dependent hypoxia-induced factor-1 alpha reactivation in mice of advanced age. Circulation. 2010 Aug 17; 122(7):707-16. PMID: 20679550.
    Citations: 28     Fields:    Translation:Animals
  127. Nishizawa T, Cheng XW, Jin Z, Obata K, Nagata K, Hirashiki A, Sasaki T, Noda A, Takeshita K, Izawa H, Shi GP, Kuzuya M, Okumura K, Murohara T. Ca(2+) channel blocker benidipine promotes coronary angiogenesis and reduces both left-ventricular diastolic stiffness and mortality in hypertensive rats. J Hypertens. 2010 Jul; 28(7):1515-26. PMID: 20543715.
    Citations: 2     Fields:    Translation:Animals
  128. Schulte S, Sun J, Libby P, Macfarlane L, Sun C, Lopez-Ilasaca M, Shi GP, Sukhova GK. Cystatin C deficiency promotes inflammation in angiotensin II-induced abdominal aortic aneurisms in atherosclerotic mice. Am J Pathol. 2010 Jul; 177(1):456-63. PMID: 20472891.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  129. Wu G, Chen T, Shahsafaei A, Hu W, Bronson RT, Shi GP, Halperin JA, Aktas H, Qin X. Complement regulator CD59 protects against angiotensin II-induced abdominal aortic aneurysms in mice. Circulation. 2010 Mar 23; 121(11):1338-46. PMID: 20212283.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  130. Shi GP. Immunomodulation of vascular diseases: atherosclerosis and autoimmunity. Eur J Vasc Endovasc Surg. 2010 Apr; 39(4):485-94. PMID: 20188603.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  131. Lu Z, Lu Z, Zhu Y, Yan Z, Liu X, Yan W, Yan S, Shi GP. Enhanced hypertension prevalence in non-Han Chinese minorities from Xinjiang Province, China. Hypertens Res. 2009 Dec; 32(12):1097-103. PMID: 19779488.
    Citations: 3     Fields:    Translation:Humans
  132. Sun J, Zhang J, Lindholt JS, Sukhova GK, Liu J, He A, Abrink M, Pejler G, Stevens RL, Thompson RW, Ennis TL, Gurish MF, Libby P, Shi GP. Critical role of mast cell chymase in mouse abdominal aortic aneurysm formation. Circulation. 2009 Sep 15; 120(11):973-82. PMID: 19720934.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  133. Yang Q, Sun Q, Zhou T, Shi G, Jin L. Determination of parathion in vegetables by electrochemical sensor based on molecularly imprinted polyethyleneimine/silica gel films. J Agric Food Chem. 2009 Aug 12; 57(15):6558-63. PMID: 19586029.
    Citations:    Fields:    Translation:Animals
  134. Liu J, Divoux A, Sun J, Zhang J, Clément K, Glickman JN, Sukhova GK, Wolters PJ, Du J, Gorgun CZ, Doria A, Libby P, Blumberg RS, Kahn BB, Hotamisligil GS, Shi GP. Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice. Nat Med. 2009 Aug; 15(8):940-5. PMID: 19633655.
    Citations: 220     Fields:    Translation:HumansAnimalsCells
  135. Cheng XW, Okumura K, Kuzuya M, Jin Z, Nagata K, Obata K, Inoue A, Hirashiki A, Takeshita K, Unno K, Harada K, Shi GP, Yokota M, Murohara T. Mechanism of diastolic stiffening of the failing myocardium and its prevention by angiotensin receptor and calcium channel blockers. J Cardiovasc Pharmacol. 2009 Jul; 54(1):47-56. PMID: 19528815.
    Citations: 11     Fields:    Translation:Animals
  136. Sá-Nunes A, Bafica A, Antonelli LR, Choi EY, Francischetti IM, Andersen JF, Shi GP, Chavakis T, Ribeiro JM, Kotsyfakis M. The immunomodulatory action of sialostatin L on dendritic cells reveals its potential to interfere with autoimmunity. J Immunol. 2009 Jun 15; 182(12):7422-9. PMID: 19494265.
    Citations: 31     Fields:    Translation:AnimalsCells
  137. Aikawa E, Aikawa M, Libby P, Figueiredo JL, Rusanescu G, Iwamoto Y, Fukuda D, Kohler RH, Shi GP, Jaffer FA, Weissleder R. Arterial and aortic valve calcification abolished by elastolytic cathepsin S deficiency in chronic renal disease. Circulation. 2009 Apr 07; 119(13):1785-94. PMID: 19307473.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  138. Wu G, Hu W, Shahsafaei A, Song W, Dobarro M, Sukhova GK, Bronson RR, Shi GP, Rother RP, Halperin JA, Qin X. Complement regulator CD59 protects against atherosclerosis by restricting the formation of complement membrane attack complex. Circ Res. 2009 Feb 27; 104(4):550-8. PMID: 19131645.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  139. Liu Y, Li X, Peng D, Tan Z, Liu H, Qing Y, Xue Y, Shi GP. Usefulness of serum cathepsin L as an independent biomarker in patients with coronary heart disease. Am J Cardiol. 2009 Feb 15; 103(4):476-81. PMID: 19195505.
    Citations: 12     Fields:    Translation:Humans
  140. Sun Y, Liang L, Zhao X, Yu L, Zhang J, Shi G, Zhou T. Determination of aromatic amines in water samples by capillary electrophoresis with amperometric detection. Water Res. 2009 Jan; 43(1):41-6. PMID: 18986668.
    Citations: 1     Fields:    Translation:PHPublic Health
  141. Ewald SE, Lee BL, Lau L, Wickliffe KE, Shi GP, Chapman HA, Barton GM. The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor. Nature. 2008 Dec 04; 456(7222):658-62. PMID: 18820679.
    Citations: 200     Fields:    Translation:AnimalsCells
  142. Yang M, Sun J, Zhang T, Liu J, Zhang J, Shi MA, Darakhshan F, Guerre-Millo M, Clement K, Gelb BD, Dolgnov G, Shi GP. Deficiency and inhibition of cathepsin K reduce body weight gain and increase glucose metabolism in mice. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2202-8. PMID: 18818416.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  143. Wang DM, Liu JR, Hu HY, Shi GP. [Cathepsin S in pathogenesis of neurological diseases]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008 Jul; 37(4):422-6. PMID: 18705018.
    Citations:    Fields:    Translation:Humans
  144. Cheng XW, Murohara T, Kuzuya M, Izawa H, Sasaki T, Obata K, Nagata K, Nishizawa T, Kobayashi M, Yamada T, Kim W, Sato K, Shi GP, Okumura K, Yokota M. Superoxide-dependent cathepsin activation is associated with hypertensive myocardial remodeling and represents a target for angiotensin II type 1 receptor blocker treatment. Am J Pathol. 2008 Aug; 173(2):358-69. PMID: 18583318.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  145. Liu M, Shi G, Zhang L, Zhao G, Jin L. Electrode modified with toluidine blue-doped silica nanoparticles, and its use for enhanced amperometric sensing of hemoglobin. Anal Bioanal Chem. 2008 Jul; 391(5):1951-9. PMID: 18415083.
    Citations:    Fields:    
  146. Schneider F, Sukhova GK, Aikawa M, Canner J, Gerdes N, Tang SM, Shi GP, Apte SS, Libby P. Matrix-metalloproteinase-14 deficiency in bone-marrow-derived cells promotes collagen accumulation in mouse atherosclerotic plaques. Circulation. 2008 Feb 19; 117(7):931-9. PMID: 18250269.
    Citations: 41     Fields:    Translation:AnimalsCells
  147. Shi GP. Role of cathepsin C in elastase-induced mouse abdominal aortic aneurysms. Future Cardiol. 2007 Nov; 3(6):591-3. PMID: 19804279.
    Citations: 6     Fields:    
  148. Sun J, Sukhova GK, Yang M, Wolters PJ, MacFarlane LA, Libby P, Sun C, Zhang Y, Liu J, Ennis TL, Knispel R, Xiong W, Thompson RW, Baxter BT, Shi GP. Mast cells modulate the pathogenesis of elastase-induced abdominal aortic aneurysms in mice. J Clin Invest. 2007 Nov; 117(11):3359-68. PMID: 17932568.
    Citations: 85     Fields:    Translation:HumansAnimalsCells
  149. Hirakawa H, Pierce RA, Bingol-Karakoc G, Karaaslan C, Weng M, Shi GP, Saad A, Weber E, Mariani TJ, Starcher B, Shapiro SD, Cataltepe S. Cathepsin S deficiency confers protection from neonatal hyperoxia-induced lung injury. Am J Respir Crit Care Med. 2007 Oct 15; 176(8):778-85. PMID: 17673697.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  150. Yang M, Zhang Y, Pan J, Sun J, Liu J, Libby P, Sukhova GK, Doria A, Katunuma N, Peroni OD, Guerre-Millo M, Kahn BB, Clement K, Shi GP. Cathepsin L activity controls adipogenesis and glucose tolerance. Nat Cell Biol. 2007 Aug; 9(8):970-7. PMID: 17643114.
    Citations: 40     Fields:    Translation:HumansAnimalsCells
  151. Sun J, Sukhova GK, Wolters PJ, Yang M, Kitamoto S, Libby P, MacFarlane LA, Mallen-St Clair J, Shi GP. Mast cells promote atherosclerosis by releasing proinflammatory cytokines. Nat Med. 2007 Jun; 13(6):719-24. PMID: 17546038.
    Citations: 116     Fields:    Translation:HumansAnimalsCells
  152. Libby P, Shi GP. Mast cells as mediators and modulators of atherogenesis. Circulation. 2007 May 15; 115(19):2471-3. PMID: 17502588.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  153. Shi G, Sun Z, Liu M, Zhang L, Liu Y, Qu Y, Jin L. Electrochemistry and electrocatalytic properties of hemoglobin in layer-by-layer films of SiO2 with vapor-surface sol-gel deposition. Anal Chem. 2007 May 15; 79(10):3581-8. PMID: 17437331.
    Citations:    Fields:    Translation:Cells
  154. Jaffer FA, Kim DE, Quinti L, Tung CH, Aikawa E, Pande AN, Kohler RH, Shi GP, Libby P, Weissleder R. Optical visualization of cathepsin K activity in atherosclerosis with a novel, protease-activatable fluorescence sensor. Circulation. 2007 May 01; 115(17):2292-8. PMID: 17420353.
    Citations: 77     Fields:    Translation:HumansAnimalsCells
  155. Kitamoto S, Sukhova GK, Sun J, Yang M, Libby P, Love V, Duramad P, Sun C, Zhang Y, Yang X, Peters C, Shi GP. Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. Circulation. 2007 Apr 17; 115(15):2065-75. PMID: 17404153.
    Citations: 42     Fields:    Translation:AnimalsCells
  156. Platt MO, Ankeny RF, Shi GP, Weiss D, Vega JD, Taylor WR, Jo H. Expression of cathepsin K is regulated by shear stress in cultured endothelial cells and is increased in endothelium in human atherosclerosis. Am J Physiol Heart Circ Physiol. 2007 Mar; 292(3):H1479-86. PMID: 17098827.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  157. Sukhova GK, Shi GP. Do cathepsins play a role in abdominal aortic aneurysm pathogenesis? Ann N Y Acad Sci. 2006 Nov; 1085:161-9. PMID: 17182932.
    Citations: 15     Fields:    Translation:HumansAnimals
  158. Wang B, Huang X, Wolters PJ, Sun J, Kitamoto S, Yang M, Riese R, Leng L, Chapman HA, Finn PW, David JR, Bucala R, Shi GP. Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses. J Immunol. 2006 Nov 01; 177(9):5779-84. PMID: 17056501.
    Citations: 11     Fields:    Translation:AnimalsCells
  159. Cheng XW, Obata K, Kuzuya M, Izawa H, Nakamura K, Asai E, Nagasaka T, Saka M, Kimata T, Noda A, Nagata K, Jin H, Shi GP, Iguchi A, Murohara T, Yokota M. Elastolytic cathepsin induction/activation system exists in myocardium and is upregulated in hypertensive heart failure. Hypertension. 2006 Nov; 48(5):979-87. PMID: 16982960.
    Citations: 27     Fields:    Translation:HumansAnimalsCells
  160. Mallen-St Clair J, Shi GP, Sutherland RE, Chapman HA, Caughey GH, Wolters PJ. Cathepsins L and S are not required for activation of dipeptidyl peptidase I (cathepsin C) in mice. Biol Chem. 2006 Aug; 387(8):1143-6. PMID: 16895486.
    Citations: 8     Fields:    Translation:AnimalsCells
  161. Packard RR, Shi GP. Atherosclerosis progression and monocyte emigration from plaque. Future Cardiol. 2006 Jul; 2(4):415-8. PMID: 19804177.
    Citations: 2     Fields:    
  162. Zhou T, Wu F, Shi G, Wang A, Hu Q, Wang X, Fang Y. Study on pharmacokinetics and tissue distribution of norvancomycin in rats by CE with electrochemical detection. Electrophoresis. 2006 May; 27(9):1790-6. PMID: 16645943.
    Citations:    Fields:    Translation:Animals
  163. Cheng XW, Kuzuya M, Nakamura K, Di Q, Liu Z, Sasaki T, Kanda S, Jin H, Shi GP, Murohara T, Yokota M, Iguchi A. Localization of cysteine protease, cathepsin S, to the surface of vascular smooth muscle cells by association with integrin alphanubeta3. Am J Pathol. 2006 Feb; 168(2):685-94. PMID: 16436681.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  164. Shi GP, Dolganov GM. Comprehensive transcriptome of proteases and protease inhibitors in vascular cells. Stroke. 2006 Feb; 37(2):537-41. PMID: 16373647.
    Citations: 6     Fields:    Translation:HumansCells
  165. Wang B, Sun J, Kitamoto S, Yang M, Grubb A, Chapman HA, Kalluri R, Shi GP. Cathepsin S controls angiogenesis and tumor growth via matrix-derived angiogenic factors. J Biol Chem. 2006 Mar 03; 281(9):6020-9. PMID: 16365041.
    Citations: 64     Fields:    Translation:HumansAnimalsCells
  166. Liu J, Ma L, Yang J, Ren A, Sun Z, Yan G, Sun J, Fu H, Xu W, Hu C, Shi GP. Increased serum cathepsin S in patients with atherosclerosis and diabetes. Atherosclerosis. 2006 Jun; 186(2):411-9. PMID: 16140306.
    Citations: 29     Fields:    Translation:Humans
  167. Shi GP. Cathepsins: novel drug targets for cardiovascular diseases? Future Cardiol. 2005 Sep; 1(5):563-5. PMID: 19804093.
    Citations:    Fields:    
  168. Liu J, Sukhova GK, Yang JT, Sun J, Ma L, Ren A, Xu WH, Fu H, Dolganov GM, Hu C, Libby P, Shi GP. Cathepsin L expression and regulation in human abdominal aortic aneurysm, atherosclerosis, and vascular cells. Atherosclerosis. 2006 Feb; 184(2):302-11. PMID: 15982660.
    Citations: 54     Fields:    Translation:HumansAnimalsCells
  169. Sukhova GK, Wang B, Libby P, Pan JH, Zhang Y, Grubb A, Fang K, Chapman HA, Shi GP. Cystatin C deficiency increases elastic lamina degradation and aortic dilatation in apolipoprotein E-null mice. Circ Res. 2005 Feb 18; 96(3):368-75. PMID: 15653570.
    Citations: 40     Fields:    Translation:AnimalsCells
  170. Pan JH, Sukhova GK, Yang JT, Wang B, Xie T, Fu H, Zhang Y, Satoskar AR, David JR, Metz CN, Bucala R, Fang K, Simon DI, Chapman HA, Libby P, Shi GP. Macrophage migration inhibitory factor deficiency impairs atherosclerosis in low-density lipoprotein receptor-deficient mice. Circulation. 2004 Jun 29; 109(25):3149-53. PMID: 15197138.
    Citations: 41     Fields:    Translation:Animals
  171. Liu J, Sukhova GK, Sun JS, Xu WH, Libby P, Shi GP. Lysosomal cysteine proteases in atherosclerosis. Arterioscler Thromb Vasc Biol. 2004 Aug; 24(8):1359-66. PMID: 15178558.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  172. Cheng XW, Kuzuya M, Sasaki T, Arakawa K, Kanda S, Sumi D, Koike T, Maeda K, Tamaya-Mori N, Shi GP, Saito N, Iguchi A. Increased expression of elastolytic cysteine proteases, cathepsins S and K, in the neointima of balloon-injured rat carotid arteries. Am J Pathol. 2004 Jan; 164(1):243-51. PMID: 14695337.
    Citations: 23     Fields:    Translation:Animals
  173. Sukhova GK, Zhang Y, Pan JH, Wada Y, Yamamoto T, Naito M, Kodama T, Tsimikas S, Witztum JL, Lu ML, Sakara Y, Chin MT, Libby P, Shi GP. Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice. J Clin Invest. 2003 Mar; 111(6):897-906. PMID: 12639996.
    Citations: 102     Fields:    Translation:AnimalsCells
  174. Pan JH, Lindholt JS, Sukhova GK, Baugh JA, Henneberg EW, Bucala R, Donnelly SC, Libby P, Metz C, Shi GP. Macrophage migration inhibitory factor is associated with aneurysmal expansion. J Vasc Surg. 2003 Mar; 37(3):628-35. PMID: 12618703.
    Citations: 13     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.