Harvard Catalyst Profiles

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Daniela M Dinulescu, Ph.D.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA233360 (LEE, HAKHO) Sep 1, 2018 - Jul 31, 2023
    Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with Nanoplasmonics
    Role: Co-Principal Investigator
  2. R03CA189462 (DINULESCU, DANIELA M) Jul 1, 2014 - Sep 30, 2016
    Defining microRNA Signatures for Early Detection in BRCA-Mutated Ovarian Cancer
    Role: Principal Investigator
  3. R01CA142746 (XU, BING) Feb 8, 2010 - Feb 28, 2026
    Enzyme-instructed self-assembly for molecular anticancer nanomedicines
    Role: Co-Principal Investigator
  4. F32CA097906 (DINULESCU, DANIELA M) Jul 1, 2005 - Dec 31, 2005
    Mouse Models of Endometriosis and Ovarian Cancer
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Li R, Ng TSC, Wang SJ, Prytyskach M, Rodell CB, Mikula H, Kohler RH, Garlin MA, Lauffenburger DA, Parangi S, Dinulescu DM, Bardeesy N, Weissleder R, Miller MA. Therapeutically reprogrammed nutrient signalling enhances nanoparticulate albumin bound drug uptake and efficacy in KRAS-mutant cancer. Nat Nanotechnol. 2021 07; 16(7):830-839. PMID: 33958764; PMCID: PMC8491539.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  2. Dejene SB, Ohman AW, Du W, Randhawa D, Bradley A, Yadav N, Elias KM, Dinulescu DM, Setlur SR. Defining fallopian tube-derived miRNA cancer signatures. Cancer Med. 2019 11; 8(15):6709-6716. PMID: 31503420.
    Citations: 4     Fields:    Translation:HumansAnimals
  3. Hüttenhain R, Choi M, Martin de la Fuente L, Oehl K, Chang CY, Zimmermann AK, Malander S, Olsson H, Surinova S, Clough T, Heinzelmann-Schwarz V, Wild PJ, Dinulescu DM, Niméus E, Vitek O, Aebersold R. A Targeted Mass Spectrometry Strategy for Developing Proteomic Biomarkers: A Case Study of Epithelial Ovarian Cancer. Mol Cell Proteomics. 2019 09; 18(9):1836-1850. PMID: 31289117.
    Citations: 11     Fields:    Translation:HumansAnimals
  4. Baldwin P, Ohman AW, Medina JE, McCarthy ET, Dinulescu DM, Sridhar S. Nanoformulation of Talazoparib Delays Tumor Progression and Ascites Formation in a Late Stage Cancer Model. Front Oncol. 2019; 9:353. PMID: 31134152; PMCID: PMC6524318.
    Citations: 7     
  5. Wang H, Feng Z, Yang C, Liu J, Medina JE, Aghvami SA, Dinulescu DM, Liu J, Fraden S, Xu B. Unraveling the Cellular Mechanism of Assembling Cholesterols for Selective Cancer Cell Death. Mol Cancer Res. 2019 04; 17(4):907-917. PMID: 30552234; PMCID: PMC6445745.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  6. Soong TR, Dinulescu DM, Xian W, Crum CP. Frontiers in the Pathology and Pathogenesis of Ovarian Cancer: Cancer Precursors and "Precursor Escape". Hematol Oncol Clin North Am. 2018 12; 32(6):915-928. PMID: 30390765.
    Citations: 3     Fields:    Translation:HumansCells
  7. Baldwin P, Ohman AW, Tangutoori S, Dinulescu DM, Sridhar S. Intraperitoneal delivery of NanoOlaparib for disseminated late-stage cancer treatment. Int J Nanomedicine. 2018; 13:8063-8074. PMID: 30555227; PMCID: PMC6278886.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  8. Kolin DL, Dinulescu DM, Crum CP. Origin of clear cell carcinoma: nature or nurture? J Pathol. 2018 Feb; 244(2):131-134. PMID: 29178260.
    Citations: 4     Fields:    Translation:Humans
  9. Tucker DW, Getchell CR, McCarthy ET, Ohman AW, Sasamoto N, Xu S, Ko JY, Gupta M, Shafrir A, Medina JE, Lee JJ, MacDonald LA, Malik A, Hasselblatt KT, Li W, Zhang H, Kaplan SJ, Murphy GF, Hirsch MS, Liu JF, Matulonis UA, Terry KL, Lian CG, Dinulescu DM. Epigenetic Reprogramming Strategies to Reverse Global Loss of 5-Hydroxymethylcytosine, a Prognostic Factor for Poor Survival in High-grade Serous Ovarian Cancer. Clin Cancer Res. 2018 03 15; 24(6):1389-1401. PMID: 29263182.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  10. Li J, Shi J, Medina JE, Zhou J, Du X, Wang H, Yang C, Liu J, Yang Z, Dinulescu DM, Xu B. Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives. Adv Healthc Mater. 2017 Aug; 6(15). PMID: 28233466.
    Citations: 12     Fields:    Translation:HumansCells
  11. Hua Y, Choi PW, Trachtenberg AJ, Ng AC, Kuo WP, Ng SK, Dinulescu DM, Matzuk MM, Berkowitz RS, Ng SW. Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. Oncotarget. 2016 Oct 04; 7(40):66077-66086. PMID: 27602775.
    Citations: 7     Fields:    Translation:AnimalsCells
  12. Kulkarni A, Pandey P, Rao P, Mahmoud A, Goldman A, Sabbisetti V, Parcha S, Natarajan SK, Chandrasekar V, Dinulescu D, Roy S, Sengupta S. Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy. ACS Nano. 2016 09 27; 10(9):8154-68. PMID: 27452234.
    Citations: 5     Fields:    Translation:Cells
  13. Li J, Kuang Y, Shi J, Zhou J, Medina JE, Zhou R, Yuan D, Yang C, Wang H, Yang Z, Liu J, Dinulescu DM, Xu B. Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells. Angew Chem Int Ed Engl. 2015 Nov 02; 54(45):13307-11. PMID: 26365295; PMCID: PMC4681442.
    Citations: 44     Fields:    Translation:HumansCells
  14. Hasan N, Ohman AW, Dinulescu DM. The promise and challenge of ovarian cancer models. Transl Cancer Res. 2015 Feb; 4(1):14-28. PMID: 26114093; PMCID: PMC4477961.
    Citations: 20     
  15. Ohman AW, Hasan N, Dinulescu DM. Advances in tumor screening, imaging, and avatar technologies for high-grade serous ovarian cancer. Front Oncol. 2014; 4:322. PMID: 25478323; PMCID: PMC4235464.
    Citations: 8     
  16. Morgan SL, Medina JE, Taylor MM, Dinulescu DM. Targeting platinum resistant disease in ovarian cancer. Curr Med Chem. 2014; 21(26):3009-20. PMID: 24735363.
    Citations: 6     Fields:    Translation:HumansCells
  17. Perets R, Wyant GA, Muto KW, Bijron JG, Poole BB, Chin KT, Chen JY, Ohman AW, Stepule CD, Kwak S, Karst AM, Hirsch MS, Setlur SR, Crum CP, Dinulescu DM, Drapkin R. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell. 2013 Dec 09; 24(6):751-65. PMID: 24332043.
    Citations: 253     Fields:    Translation:Animals
  18. Kulkarni AA, Roy B, Rao PS, Wyant GA, Mahmoud A, Ramachandran M, Sengupta P, Goldman A, Kotamraju VR, Basu S, Mashelkar RA, Ruoslahti E, Dinulescu DM, Sengupta S. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 01; 73(23):6987-97. PMID: 24121488.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  19. McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):E2939-48. PMID: 23019585.
    Citations: 150     Fields:    Translation:HumansAnimalsCells
  20. Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11294-9. PMID: 22733767.
    Citations: 34     Fields:    Translation:AnimalsCells
  21. Morgan SL, Wyant GA, Dinulescu DM. "Take it up a NOTCH": novel strategies for cancer therapy. Cell Cycle. 2013 Jan 15; 12(2):191-2. PMID: 23287472.
    Citations: 4     Fields:    Translation:HumansCells
  22. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13; 20(3):289-99. PMID: 21907921.
    Citations: 84     Fields:    Translation:HumansAnimalsCells
  23. Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B, Dinulescu DM, Mashelkar RA, Sengupta S. Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12435-40. PMID: 20616005.
    Citations: 42     Fields:    Translation:Animals
  24. Pitteri SJ, JeBailey L, Faça VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM. Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS One. 2009 Nov 19; 4(11):e7916. PMID: 19936259.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  25. Romero IL, Gordon IO, Jagadeeswaran S, Mui KL, Lee WS, Dinulescu DM, Krausz TN, Kim HH, Gilliam ML, Lengyel E. Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice. Cancer Prev Res (Phila). 2009 Sep; 2(9):792-9. PMID: 19737983.
    Citations: 10     Fields:    Translation:AnimalsCells
  26. Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008 Aug; 8(16):3210-20. PMID: 18690643.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  27. Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008; 9(6):R93. PMID: 18522751.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  28. Park SM, Shell S, Radjabi AR, Schickel R, Feig C, Boyerinas B, Dinulescu DM, Lengyel E, Peter ME. Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle. 2007 Nov 01; 6(21):2585-90. PMID: 17957144.
    Citations: 108     Fields:    Translation:HumansCells
  29. Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med. 2007 Aug; 13(8):992-7. PMID: 17676052.
    Citations: 176     Fields:    Translation:AnimalsCells
  30. Pieretti-Vanmarcke R, Donahoe PK, Pearsall LA, Dinulescu DM, Connolly DC, Halpern EF, Seiden MV, MacLaughlin DT. Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17426-31. PMID: 17088539; PMCID: PMC1859945.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  31. Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connolly D, Foster R, Dombkowski D, Preffer F, Maclaughlin DT, Donahoe PK. Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11154-9. PMID: 16849428; PMCID: PMC1544057.
    Citations: 313     Fields:    Translation:HumansAnimalsCells
  32. Daikoku T, Tranguch S, Trofimova IN, Dinulescu DM, Jacks T, Nikitin AY, Connolly DC, Dey SK. Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res. 2006 Mar 01; 66(5):2527-31. PMID: 16510568.
    Citations: 35     Fields:    Translation:AnimalsCells
  33. Kirsch DG, Dinulescu DM, Santiago PM, Jacks T. A mouse model for soft tissue sarcoma. J Clin Oncol. 2005 Jun; 23(16_suppl):9014. PMID: 27945532.
  34. Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med. 2005 Jan; 11(1):63-70. PMID: 15619626.
    Citations: 220     Fields:    Translation:Animals
  35. Dinulescu DM, Wood LJ, Shen L, Loriaux M, Corless CL, Gross AW, Ren R, Deininger MW, Druker BJ. c-CBL is not required for leukemia induction by Bcr-Abl in mice. Oncogene. 2003 Dec 04; 22(55):8852-60. PMID: 14654781.
    Citations: 7     Fields:    Translation:Animals
  36. Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, Cone RD. The central melanocortin system can directly regulate serum insulin levels. Endocrinology. 2000 Sep; 141(9):3072-9. PMID: 10965876.
    Citations: 95     Fields:    Translation:AnimalsCells
  37. Dinulescu DM, Cone RD. Agouti and agouti-related protein: analogies and contrasts. J Biol Chem. 2000 Mar 10; 275(10):6695-8. PMID: 10702221.
    Citations: 20     Fields:    Translation:AnimalsCells
  38. Robinson SW, Dinulescu DM, Cone RD. Genetic models of obesity and energy balance in the mouse. Annu Rev Genet. 2000; 34:687-745. PMID: 11092843.
    Citations: 26     Fields:    Translation:Animals
  39. Cowley MA, Pronchuk N, Fan W, Dinulescu DM, Colmers WF, Cone RD. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron. 1999 Sep; 24(1):155-63. PMID: 10677034.
    Citations: 181     Fields:    Translation:AnimalsCells
  40. Dinulescu DM, Fan W, Boston BA, McCall K, Lamoreux ML, Moore KJ, Montagno J, Cone RD. Mahogany (mg) stimulates feeding and increases basal metabolic rate independent of its suppression of agouti. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12707-12. PMID: 9770550; PMCID: PMC22895.
    Citations: 11     Fields:    Translation:Animals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.