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profileDaniela M Dinulescu, Ph.D.

TitleAssistant Professor of Pathology
InstitutionBrigham and Women's Hospital
DepartmentPathology
AddressBrigham and Womens Hospital
Pathology/EBRC room 401a
221 Longwood Ave
Boston MA 02115
Phone617/732-5318
Fax617/264-5149
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R03CA189462     (DINULESCU, DANIELA M)Jul 1, 2014 - Jun 30, 2016
NIH/NCI
Defining microRNA Signatures for Early Detection in BRCA-Mutated Ovarian Cancer
Role: Principal Investigator

R01CA142746     (XU, BING)Feb 8, 2010 - Aug 31, 2020
NIH/NCI
Enzyme-instructed self-assembly for molecular anticancer nanomedicines
Role: Co-Principal Investigator

F32CA097906     (DINULESCU, DANIELA M)Jul 1, 2005 - Dec 31, 2005
NIH/NCI
Mouse Models of Endometriosis and Ovarian Cancer
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Li J, Shi J, Medina JE, Zhou J, Du X, Wang H, Yang C, Liu J, Yang Z, Dinulescu DM, Xu B. Selectively Inducing Cancer Cell Death by Intracellular Enzyme-Instructed Self-Assembly (EISA) of Dipeptide Derivatives. Adv Healthc Mater. 2017 Aug; 6(15). PMID: 28233466.
    View in: PubMed
  2. Hua Y, Choi PW, Trachtenberg AJ, Ng AC, Kuo WP, Ng SK, Dinulescu DM, Matzuk MM, Berkowitz RS, Ng SW. Epithelialization of mouse ovarian tumor cells originating in the fallopian tube stroma. Oncotarget. 2016 Oct 04; 7(40):66077-66086. PMID: 27602775.
    View in: PubMed
  3. Kulkarni A, Pandey P, Rao P, Mahmoud A, Goldman A, Sabbisetti V, Parcha S, Natarajan SK, Chandrasekar V, Dinulescu D, Roy S, Sengupta S. Algorithm for Designing Nanoscale Supramolecular Therapeutics with Increased Anticancer Efficacy. ACS Nano. 2016 Sep 27; 10(9):8154-68. PMID: 27452234.
    View in: PubMed
  4. Li J, Kuang Y, Shi J, Zhou J, Medina JE, Zhou R, Yuan D, Yang C, Wang H, Yang Z, Liu J, Dinulescu DM, Xu B. Enzyme-Instructed Intracellular Molecular Self-Assembly to Boost Activity of Cisplatin against Drug-Resistant Ovarian Cancer Cells. Angew Chem Int Ed Engl. 2015 Nov 02; 54(45):13307-11. PMID: 26365295.
    View in: PubMed
  5. Hasan N, Ohman AW, Dinulescu DM. The promise and challenge of ovarian cancer models. Transl Cancer Res. 2015 Feb; 4(1):14-28. PMID: 26114093.
    View in: PubMed
  6. Ohman AW, Hasan N, Dinulescu DM. Advances in tumor screening, imaging, and avatar technologies for high-grade serous ovarian cancer. Front Oncol. 2014; 4:322. PMID: 25478323; PMCID: PMC4235464.
  7. Morgan SL, Medina JE, Taylor MM, Dinulescu DM. Targeting platinum resistant disease in ovarian cancer. Curr Med Chem. 2014; 21(26):3009-20. PMID: 24735363.
    View in: PubMed
  8. Perets R, Wyant GA, Muto KW, Bijron JG, Poole BB, Chin KT, Chen JY, Ohman AW, Stepule CD, Kwak S, Karst AM, Hirsch MS, Setlur SR, Crum CP, Dinulescu DM, Drapkin R. Transformation of the fallopian tube secretory epithelium leads to high-grade serous ovarian cancer in Brca;Tp53;Pten models. Cancer Cell. 2013 Dec 09; 24(6):751-65. PMID: 24332043; PMCID: PMC3917315.
  9. Kulkarni AA, Roy B, Rao PS, Wyant GA, Mahmoud A, Ramachandran M, Sengupta P, Goldman A, Kotamraju VR, Basu S, Mashelkar RA, Ruoslahti E, Dinulescu DM, Sengupta S. Supramolecular nanoparticles that target phosphoinositide-3-kinase overcome insulin resistance and exert pronounced antitumor efficacy. Cancer Res. 2013 Dec 01; 73(23):6987-97. PMID: 24121488; PMCID: PMC3855341.
  10. McAuliffe SM, Morgan SL, Wyant GA, Tran LT, Muto KW, Chen YS, Chin KT, Partridge JC, Poole BB, Cheng KH, Daggett J, Cullen K, Kantoff E, Hasselbatt K, Berkowitz J, Muto MG, Berkowitz RS, Aster JC, Matulonis UA, Dinulescu DM. Targeting Notch, a key pathway for ovarian cancer stem cells, sensitizes tumors to platinum therapy. Proc Natl Acad Sci U S A. 2012 Oct 23; 109(43):E2939-48. PMID: 23019585; PMCID: PMC3491453.
  11. Sengupta P, Basu S, Soni S, Pandey A, Roy B, Oh MS, Chin KT, Paraskar AS, Sarangi S, Connor Y, Sabbisetti VS, Kopparam J, Kulkarni A, Muto K, Amarasiriwardena C, Jayawardene I, Lupoli N, Dinulescu DM, Bonventre JV, Mashelkar RA, Sengupta S. Cholesterol-tethered platinum II-based supramolecular nanoparticle increases antitumor efficacy and reduces nephrotoxicity. Proc Natl Acad Sci U S A. 2012 Jul 10; 109(28):11294-9. PMID: 22733767; PMCID: PMC3396529.
  12. Morgan SL, Wyant GA, Dinulescu DM. "Take it up a NOTCH": novel strategies for cancer therapy. Cell Cycle. 2013 Jan 15; 12(2):191-2. PMID: 23287472; PMCID: PMC3575440.
  13. Taguchi A, Politi K, Pitteri SJ, Lockwood WW, Faça VM, Kelly-Spratt K, Wong CH, Zhang Q, Chin A, Park KS, Goodman G, Gazdar AF, Sage J, Dinulescu DM, Kucherlapati R, Depinho RA, Kemp CJ, Varmus HE, Hanash SM. Lung cancer signatures in plasma based on proteome profiling of mouse tumor models. Cancer Cell. 2011 Sep 13; 20(3):289-99. PMID: 21907921; PMCID: PMC3406925.
  14. Paraskar AS, Soni S, Chin KT, Chaudhuri P, Muto KW, Berkowitz J, Handlogten MW, Alves NJ, Bilgicer B, Dinulescu DM, Mashelkar RA, Sengupta S. Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy. Proc Natl Acad Sci U S A. 2010 Jul 13; 107(28):12435-40. PMID: 20616005; PMCID: PMC2906605.
  15. Pitteri SJ, JeBailey L, Faça VM, Thorpe JD, Silva MA, Ireton RC, Horton MB, Wang H, Pruitt LC, Zhang Q, Cheng KH, Urban N, Hanash SM, Dinulescu DM. Integrated proteomic analysis of human cancer cells and plasma from tumor bearing mice for ovarian cancer biomarker discovery. PLoS One. 2009 Nov 19; 4(11):e7916. PMID: 19936259; PMCID: PMC2775948.
  16. Romero IL, Gordon IO, Jagadeeswaran S, Mui KL, Lee WS, Dinulescu DM, Krausz TN, Kim HH, Gilliam ML, Lengyel E. Effects of oral contraceptives or a gonadotropin-releasing hormone agonist on ovarian carcinogenesis in genetically engineered mice. Cancer Prev Res (Phila). 2009 Sep; 2(9):792-9. PMID: 19737983; PMCID: PMC2758654.
  17. Abbott KL, Nairn AV, Hall EM, Horton MB, McDonald JF, Moremen KW, Dinulescu DM, Pierce M. Focused glycomic analysis of the N-linked glycan biosynthetic pathway in ovarian cancer. Proteomics. 2008 Aug; 8(16):3210-20. PMID: 18690643; PMCID: PMC3970323.
  18. Zhang Q, Menon R, Deutsch EW, Pitteri SJ, Faca VM, Wang H, Newcomb LF, Depinho RA, Bardeesy N, Dinulescu D, Hung KE, Kucherlapati R, Jacks T, Politi K, Aebersold R, Omenn GS, States DJ, Hanash SM. A mouse plasma peptide atlas as a resource for disease proteomics. Genome Biol. 2008; 9(6):R93. PMID: 18522751; PMCID: PMC2481425.
  19. Park SM, Shell S, Radjabi AR, Schickel R, Feig C, Boyerinas B, Dinulescu DM, Lengyel E, Peter ME. Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2. Cell Cycle. 2007 Nov 01; 6(21):2585-90. PMID: 17957144.
    View in: PubMed
  20. Kirsch DG, Dinulescu DM, Miller JB, Grimm J, Santiago PM, Young NP, Nielsen GP, Quade BJ, Chaber CJ, Schultz CP, Takeuchi O, Bronson RT, Crowley D, Korsmeyer SJ, Yoon SS, Hornicek FJ, Weissleder R, Jacks T. A spatially and temporally restricted mouse model of soft tissue sarcoma. Nat Med. 2007 Aug; 13(8):992-7. PMID: 17676052.
    View in: PubMed
  21. Pieretti-Vanmarcke R, Donahoe PK, Pearsall LA, Dinulescu DM, Connolly DC, Halpern EF, Seiden MV, MacLaughlin DT. Mullerian Inhibiting Substance enhances subclinical doses of chemotherapeutic agents to inhibit human and mouse ovarian cancer. Proc Natl Acad Sci U S A. 2006 Nov 14; 103(46):17426-31. PMID: 17088539; PMCID: PMC1859945.
  22. Szotek PP, Pieretti-Vanmarcke R, Masiakos PT, Dinulescu DM, Connolly D, Foster R, Dombkowski D, Preffer F, Maclaughlin DT, Donahoe PK. Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsiveness. Proc Natl Acad Sci U S A. 2006 Jul 25; 103(30):11154-9. PMID: 16849428; PMCID: PMC1544057.
  23. Daikoku T, Tranguch S, Trofimova IN, Dinulescu DM, Jacks T, Nikitin AY, Connolly DC, Dey SK. Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer. Cancer Res. 2006 Mar 01; 66(5):2527-31. PMID: 16510568.
    View in: PubMed
  24. Kirsch DG, Dinulescu DM, Santiago PM, Jacks T. A mouse model for soft tissue sarcoma. J Clin Oncol. 2005 Jun; 23(16_suppl):9014. PMID: 27945532.
    View in: PubMed
  25. Dinulescu DM, Ince TA, Quade BJ, Shafer SA, Crowley D, Jacks T. Role of K-ras and Pten in the development of mouse models of endometriosis and endometrioid ovarian cancer. Nat Med. 2005 Jan; 11(1):63-70. PMID: 15619626.
    View in: PubMed
  26. Dinulescu DM, Wood LJ, Shen L, Loriaux M, Corless CL, Gross AW, Ren R, Deininger MW, Druker BJ. c-CBL is not required for leukemia induction by Bcr-Abl in mice. Oncogene. 2003 Dec 04; 22(55):8852-60. PMID: 14654781.
    View in: PubMed
  27. Fan W, Dinulescu DM, Butler AA, Zhou J, Marks DL, Cone RD. The central melanocortin system can directly regulate serum insulin levels. Endocrinology. 2000 Sep; 141(9):3072-9. PMID: 10965876.
    View in: PubMed
  28. Dinulescu DM, Cone RD. Agouti and agouti-related protein: analogies and contrasts. J Biol Chem. 2000 Mar 10; 275(10):6695-8. PMID: 10702221.
    View in: PubMed
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