Harvard Catalyst Profiles

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Myron Spector, Ph.D.

Profile Picture
Other Positions

Elizabeth Winston-Lanier Kappa Delta Award
Clemson Award for Applied Biomaterials Research
Research Career Scientist Award
John Charnley Award
Chandra P. Sharma Award

Director, Orthopaedic Research Laboratory, Brigham and Women's Hospital
Director, Tissue Engineering Laboratory, VA Boston Healthcare System
Senior Lecturer, Mechanical Engineering , MIT

Prof. Spector has been engaged in biomaterials research for over 30 years, and in tissue engineering studies for 15 years, employing animal models and cell culture systems. He is supervising investigations related to musculoskeletal and nerve regeneration, involving biopolymer sponge-like scaffolds and injectable gels. He recently has established projects demonstrating the potential of extracorporeal shock wave treatment to enhance the make-up of select tissues to be used as autografts for bone and cartilage repair.

Prof. Spector teaches 4 subjects at MIT: Biomaterial-Tissue Interactions (2.79J/3.96J/BEH.441HST 522J); Cell-Matrix Mechanics (2.785J/3.97J/20.411J/HST523J); Design of Medical Devices/Implants (2.782J/3.961J/20.451J/HST524J); and Principles and Practice of Tissue Engineering (HST.535). He is the principal research supervisor for students in: MIT doctoral programs; Harvard Medical School; and postgraduate programs at the Harvard School of Dental Medicine. His postdoctoral research fellows come with varied backgrounds from many countries.

Dr. Spector is a VA Research Career Scientist.

Other Positions:
2005-present: Co-Editor-in Chief, Biomedical Materials: Materials for Tissue Engineering & Regenerative Medicine
1993-1997: Chairman, Food and Drug Administration General and Plastic Surgery Devices Advisory Panel
1990-1991: President, Society for Biomaterials

The Role of Lubricin in the Impaired Healing of Ruptured Ligaments and in the Therapeutic Treatment of Ligaments with Extracorporeal Shock Waves
Summer, 05/24/10 - 08/31/10
Contractile Behavior of Human Periodontal Ligament Fibroblasts in Collagen Matrices in vitro
Summer, 05/01/99 - 08/31/99
Regulation of Contractile Behavior of Fibroblasts in Inured Rotator Cuffs and Huypertrophic Scars
Part Time, 01/03/00 - 06/15/00
Tissue Engineering and Stem Cell Research
Summer, 07/01/03 - 08/31/03
The Identificaiton of Myofibroblast in Oral Lesions
Summer, 06/23/99 - 08/31/99
Contraction and Shrinkage of Collagen Matrices by Exogenous Cells from Ligament Extract
Part Time/Continuation, 01/01/99 - 06/18/99
Non-Viral Transfection of Caprine Mesenchymal Stem Cells with BMP-7 Plasmid: Effects of Plasmid Size and Type of Medium
Summer, 06/02/08 - 08/29/08
Mesenchymal stem cells on Type II collagen/GAG scaffolds for cartilage regeneration
Summer, 07/30/07 - 01/31/07

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01AR040427 (SPECTOR, MYRON) Sep 20, 1991 - Aug 31, 1995
    Role: Principal Investigator
  2. R01DE006300 (SPECTOR, MYRON) Mar 1, 1982 - Jul 31, 1987
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Alshihri A, Niu W, Kämmerer PW, Al-Askar M, Yamashita A, Kurisawa M, Spector M. The effects of shock wave stimulation of mesenchymal stem cells on proliferation, migration, and differentiation in an injectable gelatin matrix for osteogenic regeneration. J Tissue Eng Regen Med. 2020 Nov; 14(11):1630-1640. PMID: 32885906.
    Citations:    Fields:    
  2. Spector M. An interview with Jianwu Dai: understanding the biological processes underlying regeneration to direct the implementation of biomedical materials. Biomed Mater. 2020 05 07; 15(3):030201. PMID: 32031996.
    Citations:    Fields:    
  3. Rajappa R, Nazal MR, Stelzer JW, Hsu HP, Conaway WK, Rokkappanavar S, Niu W, Upadhyaya S, Alpaugh K, Spector M, Martin SD. Translational relevance of the goat as a preclinical model of the human labrum and chondrolabral junction-histological study. J Orthop Res. 2020 05; 38(5):1070-1080. PMID: 31788831.
    Citations:    Fields:    Translation:HumansAnimals
  4. Chan SJ, Niu W, Hayakawa K, Hamanaka G, Wang X, Cheah PS, Guo S, Yu Z, Arai K, Selim MH, Kurisawa M, Spector M, Lo EH. Promoting Neuro-Supportive Properties of Astrocytes with Epidermal Growth Factor Hydrogels. Stem Cells Transl Med. 2019 12; 8(12):1242-1248. PMID: 31483567.
    Citations:    Fields:    Translation:AnimalsCells
  5. Alshihri A, Kämmerer PW, Heimes D, Niu W, Alnassar T, Spector M. Extracorporeal Shock Wave Stimulates Angiogenesis and Collagen Production in Facial Soft Tissue. J Surg Res. 2020 01; 245:483-491. PMID: 31446190.
    Citations:    Fields:    Translation:HumansAnimals
  6. Lim TC, Mandeville E, Weng D, Wang LS, Kurisawa M, Leite-Morris K, Selim MH, Lo EH, Spector M. Hydrogel-Based Therapy for Brain Repair After Intracerebral Hemorrhage. Transl Stroke Res. 2020 06; 11(3):412-417. PMID: 31432328.
    Citations: 1     Fields:    
  7. Love CJ, Selim M, Spector M, Lo EH. Biomaterials for Stroke Therapy. Stroke. 2019 08; 50(8):2278-2284. PMID: 31177979.
    Citations: 1     Fields:    Translation:Humans
  8. Spector M. An interview with Joyce Y Wong: ensuring all voices in biomaterials community are heard. Biomed Mater. 2019 03 27; 14(3):030201. PMID: 30916043.
    Citations:    Fields:    Translation:Humans
  9. Park J, Baranov P, Aydin A, Abdelgawad H, Singh D, Niu W, Kurisawa M, Spector M, Young MJ. In Situ Cross-linking Hydrogel as a Vehicle for Retinal Progenitor Cell Transplantation. Cell Transplant. 2019 05; 28(5):596-606. PMID: 30917696.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  10. Deng W, Shao F, He Q, Wang Q, Shi W, Yu Q, Cao X, Feng C, Bi S, Chen J, Ma P, Li Y, Gong A, Tong S, Yu J, Spector M, Xu X, Zhang Z. EMSCs Build an All-in-One Niche via Cell-Cell Lipid Raft Assembly for Promoted Neuronal but Suppressed Astroglial Differentiation of Neural Stem Cells. . 2019 Mar; 31(10):e1806861. PMID: 30633831.
    Citations: 2     Translation:HumansAnimalsCells
  11. Grossner T, Gotterbarm T, Gerbaudo VH, Haberkorn U, Spector M. 99mTc-Methyl-Diphosphonate Binding to Mineral Deposits in Cultures of Marrow-Derived Mesenchymal Stem Cells in Osteogenic Medium. Tissue Eng Part C Methods. 2019 01; 25(1):49-57. PMID: 30560717.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  12. Cao X, Wang J, Deng W, Chen J, Wang Y, Zhou J, Du P, Xu W, Wang Q, Wang Q, Yu Q, Spector M, Yu J, Xu X. Photoluminescent Cationic Carbon Dots as efficient Non-Viral Delivery of Plasmid SOX9 and Chondrogenesis of Fibroblasts. Sci Rep. 2018 05 04; 8(1):7057. PMID: 29728593.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Spector M. Biomedical materials to meet the challenges of the aging epidemic. Biomed Mater. 2018 03 16; 13(3):030201. PMID: 29546842.
    Citations:    Fields:    Translation:HumansAnimals
  14. Ambra LF, de Girolamo L, Niu W, Phan A, Spector M, Gomoll AH. No effect of topical application of tranexamic acid on articular cartilage. Knee Surg Sports Traumatol Arthrosc. 2019 Mar; 27(3):931-935. PMID: 29119286.
    Citations: 4     Fields:    Translation:AnimalsCells
  15. Chen J, Wang Q, Zhou J, Deng W, Yu Q, Cao X, Wang J, Shao F, Li Y, Ma P, Spector M, Yu J, Xu X. Porphyra polysaccharide-derived carbon dots for non-viral co-delivery of different gene combinations and neuronal differentiation of ectodermal mesenchymal stem cells. Nanoscale. 2017 Aug 03; 9(30):10820-10831. PMID: 28726952.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  16. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 07 15; 26(14):1078-1085. PMID: 28446066.
    Citations: 1     Fields:    Translation:AnimalsCells
  17. Chan SJ, Love C, Spector M, Cool SM, Nurcombe V, Lo EH. Endogenous regeneration: Engineering growth factors for stroke. Neurochem Int. 2017 Jul; 107:57-65. PMID: 28411103.
    Citations: 10     Fields:    Translation:HumansAnimals
  18. Foldager CB, Bendtsen M, Berg LC, Brinchmann JE, Brittberg M, Bunger C, Canseco J, Chen L, Christensen BB, Colombier P, Deleuran BW, Edwards J, Elmengaard B, Farr J, Gatenholm B, Gomoll AH, Hui JH, Jakobsen RB, Joergensen NL, Kassem M, Koch T, Kold S, Krogsgaard MR, Lauridsen H, Le D, Le Visage C, Lind M, Nygaard JV, Olesen ML, Pedersen M, Rathcke M, Richardson JB, Roberts S, Rölfing JH, Sakai D, Toh WS, Urban J, Spector M. Aarhus Regenerative Orthopaedics Symposium (AROS). Acta Orthop. 2016 Dec; 87(sup363):1-5. PMID: 28271925.
    Citations: 1     Fields:    Translation:HumansAnimals
  19. Zhang Z, Li Z, Deng W, He Q, Wang Q, Shi W, Chen Q, Yang W, Spector M, Gong A, Yu J, Xu X. Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochem Biophys Res Commun. 2016 11 25; 480(4):727-733. PMID: 27983986.
    Citations: 2     Fields:    Translation:AnimalsCells
  20. Spector M. An interview with Arthur J Coury: an extensively experienced perspective on medical device development. Biomed Mater. 2016 10 06; 11(5):050401. PMID: 27710920.
    Citations:    Fields:    Translation:Humans
  21. Toh WS, Brittberg M, Farr J, Foldager CB, Gomoll AH, Hui JH, Richardson JB, Roberts S, Spector M. Cellular senescence in aging and osteoarthritis. Acta Orthop. 2016 Dec; 87(sup363):6-14. PMID: 27658487.
    Citations: 13     Fields:    Translation:Humans
  22. Lim TC, Spector M. Biomaterials for Enhancing CNS Repair. Transl Stroke Res. 2017 02; 8(1):57-64. PMID: 27251413.
    Citations: 9     Fields:    Translation:Humans
  23. Spector M. The living legacy of a biomaterials founder: remembering Samuel F Hulbert, PhD. Biomed Mater. 2016 Mar 22; 11(2):020202. PMID: 27001792.
    Citations:    Fields:    Translation:HumansAnimals
  24. Spector M. Decellularized tissues and organs: an historical perspective and prospects for the future. Biomed Mater. 2016 Mar 17; 11(2):020201. PMID: 26989090.
    Citations: 1     Fields:    Translation:HumansCells
  25. Min J, Choi KY, Dreaden EC, Padera RF, Braatz RD, Spector M, Hammond PT. Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair. ACS Nano. 2016 04 26; 10(4):4441-50. PMID: 26923427.
    Citations: 15     Fields:    Translation:HumansAnimals
  26. Spector M, Lim TC. Injectable biomaterials: a perspective on the next wave of injectable therapeutics. Biomed Mater. 2016 Feb 02; 11(1):014110. PMID: 26836246.
    Citations: 3     Fields:    
  27. Foldager CB, Toh WS, Christensen BB, Lind M, Gomoll AH, Spector M. Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects. Cartilage. 2016 Jan; 7(1):52-61. PMID: 26958317.
    Citations: 5     Fields:    
  28. Toh WS, Foldager CB, Hui JH, Olsen BR, Spector M. Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules. Curr Stem Cell Res Ther. 2016; 11(8):618-625. PMID: 26201861.
    Citations: 3     Fields:    Translation:HumansAnimalsCells
  29. Spector M. An auspicious decade for biomedical materials. Biomed Mater. 2015 Dec 23; 11(1):010201. PMID: 26693853.
    Citations:    Fields:    
  30. Foldager CB, Nyengaard JR, Lind M, Spector M. A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue. Cartilage. 2015 Apr; 6(2):123-32. PMID: 26069715.
    Citations: 4     Fields:    
  31. Spector M. The CEO as a medical device 'translator': a remembrance of Peter Geistlich, PhD. Biomed Mater. 2014 Sep 27; 9(5):050401. PMID: 25262615.
    Citations:    Fields:    Translation:Humans
  32. Shah NJ, Hyder MN, Quadir MA, Dorval Courchesne NM, Seeherman HJ, Nevins M, Spector M, Hammond PT. Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12847-52. PMID: 25136093.
    Citations: 28     Fields:    Translation:Animals
  33. Ying JY, Spector M. An interview with Jackie Yi-Ru Ying: the compleat multi-tasker. Biomed Mater. 2014 Jun; 9(3):030401. PMID: 24818688.
    Citations:    Fields:    
  34. Foldager CB, Toh WS, Gomoll AH, Olsen BR, Spector M. Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues. Cartilage. 2014 Apr; 5(2):123-32. PMID: 26069692.
    Citations: 10     Fields:    
  35. Johnson LL, Delano M, Spector M, Pittsley A, Gottschalk A. The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up. Cartilage. 2014 Apr; 5(2):86-96. PMID: 26069688.
    Citations: 1     Fields:    
  36. Spector M. The tissue engineer's toolbox manifesto. Biomed Mater. 2014 Feb; 9(1):010201. PMID: 24457154.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Shoichet MS. An interview with Molly S Shoichet. Developing biomaterials and mobilizing resources for assaults on some of the most devastating medical problems by Myron Spector. Biomed Mater. 2013 Dec; 8(6):060401. PMID: 24287970.
    Citations:    Fields:    Translation:HumansAnimals
  38. Shah NJ, Hyder MN, Moskowitz JS, Quadir MA, Morton SW, Seeherman HJ, Padera RF, Spector M, Hammond PT. Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings. Sci Transl Med. 2013 Jun 26; 5(191):191ra83. PMID: 23803705.
    Citations: 35     Fields:    Translation:Animals
  39. Jeng L, Hsu HP, Spector M. Tissue-engineered cartilaginous constructs for the treatment of caprine cartilage defects, including distribution of laminin and type IV collagen. Tissue Eng Part A. 2013 Oct; 19(19-20):2267-74. PMID: 23672504.
    Citations: 7     Fields:    Translation:Animals
  40. Lee IS, Spector M. 'What led you to do that?' And other questions for the leaders of our field: the BMM Interview. Biomed Mater. 2013 Aug; 8(4):040201. PMID: 23715035.
    Citations:    Fields:    
  41. Yannas IV. An interview with I V Yannas. Tracing one of the deepest roots of biomaterials in tissue engineering/regenerative medicine. Interview by Myron Spector. Biomed Mater. 2013 Aug; 8(4):040401. PMID: 23715065.
    Citations:    Fields:    Translation:HumansAnimals
  42. Lee IS, Spector M. Biomedical materials and 2013. Biomed Mater. 2013 Apr; 8(2):020201. PMID: 23528391.
    Citations:    Fields:    
  43. Toh WS, Foldager CB, Olsen BR, Spector M. Basement membrane molecule expression attendant to chondrogenesis by nucleus pulposus cells and mesenchymal stem cells. J Orthop Res. 2013 Jul; 31(7):1136-43. PMID: 23508654.
    Citations: 8     Fields:    Translation:AnimalsCells
  44. Wada K, Gerbaudo VH, Spector M. Effects of PDGF-BB and OP-1 on mesenchymal stem cells in a porous mineral block. Int J Periodontics Restorative Dent. 2013 Mar-Apr; 33(2):e72-8. PMID: 23484183.
    Citations: 1     Fields:    Translation:AnimalsCells
  45. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    Citations: 16     Fields:    Translation:AnimalsCells
  46. Lim TC, Rokkappanavar S, Toh WS, Wang LS, Kurisawa M, Spector M. Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1a release and compatible structural support. FASEB J. 2013 Mar; 27(3):1023-33. PMID: 23193174.
    Citations: 9     Fields:    Translation:AnimalsCells
  47. Lee IS, Spector M. The people behind the papers, and how much data is enough? Biomed Mater. 2012 Dec 1; 7(6):060201-60201. PMID: 23183909.
  48. Cheriyan T, Ready JE, Brick GW, Martin SD, Martin TL, Schmid TM, Padera RF, Spector M. Lubricin and smooth muscle a-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses. Acta Biomater. 2013 Mar; 9(3):5751-8. PMID: 23174700.
    Citations: 1     Fields:    Translation:HumansCells
  49. Elias PZ, Spector M. Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor. J Tissue Eng Regen Med. 2015 Feb; 9(2):137-50. PMID: 23038669.
    Citations: 2     Fields:    Translation:AnimalsCells
  50. Cholas R, Hsu HP, Spector M. Collagen scaffolds incorporating select therapeutic agents to facilitate a reparative response in a standardized hemiresection defect in the rat spinal cord. Tissue Eng Part A. 2012 Oct; 18(19-20):2158-72. PMID: 22827732.
    Citations: 9     Fields:    Translation:AnimalsCells
  51. Foldager CB, Kearney C, Spector M. Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock waves. Ultrasound Med Biol. 2012 Oct; 38(10):1673-80. PMID: 22920552.
    Citations: 11     Fields:    Translation:Humans
  52. Cheriyan T, Guo L, Orgill DP, Padera RF, Schmid TM, Spector M. Lubricin in human breast tissue expander capsules. . 2012 Oct; 100(7):1961-9. PMID: 22865664.
    Citations: 2     Translation:HumansCells
  53. Elias PZ, Spector M. Characterization of a bilateral penetrating brain injury in rats and evaluation of a collagen biomaterial for potential treatment. J Neurotrauma. 2012 Jul 20; 29(11):2086-102. PMID: 22519932.
    Citations:    Fields:    Translation:Animals
  54. Elias PZ, Spector M. Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury. J Neurosci Methods. 2012 Jul 30; 209(1):199-211. PMID: 22698665.
    Citations: 9     Fields:    Translation:AnimalsCells
  55. Kearney CJ, Hsu HP, Spector M. The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation. Tissue Eng Part A. 2012 Jul; 18(13-14):1500-8. PMID: 22519654.
    Citations: 3     Fields:    Translation:AnimalsCells
  56. Zhang D, Cheriyan T, Martin SD, Schmid TM, Spector M. Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints. Cartilage. 2012 Apr; 3(2):165-72. PMID: 26069629.
    Citations:    Fields:    
  57. Foldager CB, Gomoll AH, Lind M, Spector M. Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair. Cartilage. 2012 Apr; 3(2):108-17. PMID: 26069624.
    Citations: 12     Fields:    
  58. Elias PZ, Spector M. Viscoelastic characterization of rat cerebral cortex and type I collagen scaffolds for central nervous system tissue engineering. J Mech Behav Biomed Mater. 2012 Aug; 12:63-73. PMID: 22659367.
    Citations: 1     Fields:    Translation:Animals
  59. Toh WS, Lim TC, Kurisawa M, Spector M. Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. Biomaterials. 2012 May; 33(15):3835-45. PMID: 22369963.
    Citations: 32     Fields:    Translation:AnimalsCells
  60. Jeng L, Olsen BR, Spector M. Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels. Acta Biomater. 2012 Jul; 8(6):2203-12. PMID: 22370447.
    Citations: 4     Fields:    Translation:AnimalsCells
  61. Lim TC, Toh WS, Wang LS, Kurisawa M, Spector M. The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. Biomaterials. 2012 Apr; 33(12):3446-55. PMID: 22306021.
    Citations: 18     Fields:    Translation:AnimalsCells
  62. Lee IS, Spector M. Coping with copying and conflicts (of interest). Biomed Mater. 2012 Feb; 7(1):010201. PMID: 22287538.
    Citations:    Fields:    
  63. Johnson LL, DeLano MC, Spector M, Jeng L, Pittsley A, Gottschalk A. The Biological Response following Autogenous Bone Grafting for Large-Volume Defects of the Knee: Index Surgery through 12 to 21 Years' Follow-up. Cartilage. 2012 Jan; 3(1):86-99. PMID: 26069622.
    Citations: 1     Fields:    
  64. Cholas RH, Hsu HP, Spector M. The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model. Biomaterials. 2012 Mar; 33(7):2050-9. PMID: 22182744.
    Citations: 16     Fields:    Translation:HumansAnimals
  65. Cheriyan T, Schmid TM, Spector M. Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbits. Mol Vis. 2011; 17:3055-61. PMID: 22162624.
    Citations: 3     Fields:    Translation:Animals
  66. Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M. Extracorporeal shockwave-induced expression of lubricin in tendons and septa. Cell Tissue Res. 2011 Nov; 346(2):255-62. PMID: 22009294.
    Citations: 5     Fields:    Translation:AnimalsCells
  67. Ng KK, Thatte HS, Spector M. Chondrogenic differentiation of adult mesenchymal stem cells and embryonic cells in collagen scaffolds. J Biomed Mater Res A. 2011 Nov; 99(2):275-82. PMID: 21858916.
    Citations: 6     Fields:    Translation:AnimalsCells
  68. Zhang D, Cheriyan T, Martin SD, Gomoll AH, Schmid TM, Spector M. Lubricin distribution in the torn human anterior cruciate ligament and meniscus. J Orthop Res. 2011 Dec; 29(12):1916-22. PMID: 21647956.
    Citations: 8     Fields:    Translation:Humans
  69. Toh WS, Spector M, Lee EH, Cao T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm. 2011 Aug 01; 8(4):994-1001. PMID: 21500855.
    Citations: 13     Fields:    Translation:Humans
  70. Kearney CJ, Lee JY, Padera RF, Hsu HP, Spector M. Extracorporeal shock wave-induced proliferation of periosteal cells. J Orthop Res. 2011 Oct; 29(10):1536-43. PMID: 21448986.
    Citations: 3     Fields:    Translation:Animals
  71. Krevolin J, Liu JJ, Wallen A, Patel K, Dahl R, Hsu H-P, Kearney C, Spector M. Proceedings of the 35th Int. Conf on Advanced Ceramics and Composites. Tissue ingrowth in resorbable porous tissue scaffolds. 2011.
  72. Perez RA, Ginebra MP, and Spector M. J. Materials Sci. Mater. in Med. Cell response to collagen-calcium phosphate cement scaffolds investigated for nonviral gene delivery. 2011; 22:887-897.
  73. Johnson LJ, Verioti C, Gelber C, Spector M, and D’Lima D. The Knee. The pathology of the end stage osteoarthritic lesion of the knee: Potential role in cartilage repair. 2011; 18:402-6.
  74. Johnson LL, Verioti C, Gelber J, Spector M, D'Lima D, Pittsley A. The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair. Knee. 2011 Dec; 18(6):402-6. PMID: 20934341.
    Citations: 2     Fields:    Translation:HumansCells
  75. Jeng L, Olsen BR, Spector M. Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds. Tissue Eng Part A. 2010 Oct; 16(10):3011-21. PMID: 20545556.
    Citations: 8     Fields:    Translation:AnimalsCells
  76. Vickers SM, Gotterbarm T, Spector M. Cross-linking affects cellular condensation and chondrogenesis in type II collagen-GAG scaffolds seeded with bone marrow-derived mesenchymal stem cells. J Orthop Res. 2010 Sep; 28(9):1184-92. PMID: 20225321.
    Citations: 20     Fields:    Translation:AnimalsCells
  77. Zhang L, Spector M. Synovium tissue engineering to prevent tendon sheath adhesion. Plast Reconstr Surg. 2010 Jul; 126(1):44e-45e. PMID: 20595850.
    Citations:    Fields:    Translation:AnimalsCells
  78. Funakoshi T, Spector M. Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells. J Orthop Res. 2010 Jun; 28(6):716-25. PMID: 20058273.
    Citations: 1     Fields:    Translation:AnimalsCells
  79. Moskowitz JS, Blaisse MR, Samuel RE, Hsu HP, Harris MB, Martin SD, Lee JC, Spector M, Hammond PT. The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model. Biomaterials. 2010 Aug; 31(23):6019-30. PMID: 20488534.
    Citations: 17     Fields:    Translation:AnimalsCells
  80. Funakoshi T, Martin SD, Wolf BT, Schmid TM, Thornhill TS, Spector M. alpha-Smooth muscle actin-expressing cells and lubricin in periprosthetic tissue. J Biomed Mater Res A. 2010 May; 93(2):515-27. PMID: 19585565.
    Citations: 1     Fields:    Translation:HumansAnimals
  81. Kobayashi M, Spector M. In vitro response of the bone marrow-derived mesenchymal stem cells seeded in a type-I collagen-glycosaminoglycan scaffold for skin wound repair under the mechanical loading condition. Mol Cell Biomech. 2009 Dec; 6(4):217-27. PMID: 19899445.
    Citations: 5     Fields:    Translation:AnimalsCells
  82. Funakoshi T, Martin SD, Schmid TM, Spector M. Distribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot study. Clin Orthop Relat Res. 2010 Jun; 468(6):1588-99. PMID: 19798542.
    Citations: 10     Fields:    Translation:Humans
  83. Shine KM, Simson JA, Spector M. Lubricin distribution in the human intervertebral disc. J Bone Joint Surg Am. 2009 Sep; 91(9):2205-12. PMID: 19723998.
    Citations: 13     Fields:    Translation:HumansAnimals
  84. Zhang L, Spector M. Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering. Biomed Mater. 2009 Aug; 4(4):045012. PMID: 19636108.
    Citations: 8     Fields:    Translation:AnimalsCells
  85. Wang TW, Spector M. Development of hyaluronic acid-based scaffolds for brain tissue engineering. Acta Biomater. 2009 Sep; 5(7):2371-84. PMID: 19403351.
    Citations: 22     Fields:    Translation:AnimalsCells
  86. Wu H-C, Wang T-W, Bohn MC, Lin F-H, and Spector M. Advanced Functional Materials. Novel magnetic hydroxyapatite nanoparticles as non-viral vectors for the glial cell line-derived neurotrophic factor gene. 2009; 19:1-11.
  87. Sun XD, Jeng L, Bolliet C, Olsen BR, Spector M. Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials. 2009 Feb; 30(6):1222-31. PMID: 19059640.
    Citations: 10     Fields:    Translation:AnimalsCells
  88. Shine KM, Spector M. The presence and distribution of lubricin in the caprine intervertebral disc. J Orthop Res. 2008 Oct; 26(10):1398-406. PMID: 18464265.
    Citations: 12     Fields:    Translation:AnimalsCells
  89. Bolliet C, Bohn MC, Spector M. Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold. Tissue Eng Part C Methods. 2008 Sep; 14(3):207-19. PMID: 18721070.
    Citations: 7     Fields:    Translation:AnimalsCells
  90. Spector M. Ideas and inspiration: a remembrance of Philip J Boyne, DMD, MS, DSc. Biomed Mater. 2008 Sep; 3(3):030401. PMID: 18591731.
    Citations:    Fields:    
  91. Madaghiele M, Sannino A, Yannas IV, Spector M. Collagen-based matrices with axially oriented pores. J Biomed Mater Res A. 2008 Jun 01; 85(3):757-67. PMID: 17896767.
    Citations: 27     Fields:    Translation:Humans
  92. Funakoshi T, Schmid T, Hsu HP, Spector M. Lubricin distribution in the goat infraspinatus tendon: a basis for interfascicular lubrication. J Bone Joint Surg Am. 2008 Apr; 90(4):803-14. PMID: 18381319.
    Citations: 18     Fields:    Translation:Animals
  93. Xu X, Capito RM, Spector M. Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes. J Biomed Mater Res A. 2008 Mar 15; 84(4):1038-48. PMID: 17685397.
    Citations: 6     Fields:    Translation:HumansCells
  94. Pfeiffer E, Vickers SM, Frank E, Grodzinsky AJ, and Spector M. Osteoarth. and Cart. The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds. 2008; 16:1237-1244.
  95. Xu X, Capito RM, Spector M. Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles. J Biomed Mater Res A. 2008 Jan; 84(1):73-83. PMID: 17600330.
    Citations: 5     Fields:    Translation:AnimalsCells
  96. Ma J, Tian WM, Hou SP, Xu QY, Spector M, Cui FZ. An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. Biomed Mater. 2007 Dec; 2(4):233-40. PMID: 18458480.
    Citations: 18     Fields:    Translation:Animals
  97. Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH. Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng. 2007 Sep; 13(9):2227-37. PMID: 17561802.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
  98. Tang S, Vickers SM, Hsu HP, Spector M. Fabrication and characterization of porous hyaluronic acid-collagen composite scaffolds. J Biomed Mater Res A. 2007 Aug; 82(2):323-35. PMID: 17295240.
    Citations: 6     Fields:    Translation:AnimalsCells
  99. Tang S, Spector M. Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesis. Biomed Mater. 2007 Sep; 2(3):S135-41. PMID: 18458458.
    Citations: 4     Fields:    Translation:AnimalsCells
  100. Zhang D, Johnson LJ, Hsu HP, Spector M. Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. J Orthop Res. 2007 Jul; 25(7):873-83. PMID: 17343281.
    Citations: 13     Fields:    Translation:HumansCells
  101. Spector M. Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2007 Mar 02; 137 Suppl 155:157S-165S. PMID: 17874524.
    Citations: 4     Fields:    
  102. Ma J, Tian W-M, Hou S-P, Xu Q-Y, Spector M, and Cui F-Z. Biomed. Mater.: Mater. in Tissue Engr. and Regen. Med. An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. 2007; 2:233-240.
  103. Hunziker E, Spector M, Libera J, Gertzman A, Woo SL, Ratcliffe A, Lysaght M, Coury A, Kaplan D, Vunjak-Novakovic G. Translation from research to applications. Tissue Eng. 2006 Dec; 12(12):3341-64. PMID: 17518672.
    Citations: 12     Fields:    Translation:HumansAnimals
  104. Xiang Z, Liao R, Kelly MS, Spector M. Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006 Sep; 12(9):2467-78. PMID: 16995780.
    Citations: 19     Fields:    Translation:AnimalsCells
  105. Spector M. Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2006 May 13; 136(19-20):293-301. PMID: 16741852.
    Citations: 8     Fields:    Translation:Humans
  106. Sun W, Yan Y, Lin F, Spector M. Biomanufacturing: a US-China National Science Foundation-sponsored workshop. Tissue Eng. 2006 May; 12(5):1169-81. PMID: 16771632.
    Citations: 4     Fields:    
  107. Vickers SM, Squitieri LS, Spector M. Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation. Tissue Eng. 2006 May; 12(5):1345-55. PMID: 16771647.
    Citations: 29     Fields:    Translation:AnimalsCells
  108. Wang H, Eliaz N, Xiang Z, Hsu HP, Spector M, Hobbs LW. Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy. Biomaterials. 2006 Aug; 27(23):4192-203. PMID: 16618502.
    Citations: 22     Fields:    Translation:Animals
  109. Mazzucco, D and Spector, M. J. Tribology. Contact area as a critical determinant in the tribology of metal-on-polyethylene total joint arthroplasty. 2006; 128:113-121.
  110. Chen P, Marsilio E, Goldstein RH, Yannas IV, Spector M. Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro. Tissue Eng. 2005 Sep-Oct; 11(9-10):1436-48. PMID: 16259599.
    Citations: 15     Fields:    Translation:AnimalsCells
  111. Mazzucco D, Spector M. The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty. Clin Orthop Relat Res. 2004 Dec; (429):17-32. PMID: 15577461.
    Citations: 4     Fields:    Translation:HumansAnimals
  112. Wang H, Gerbaudo VH, Hobbs LW, Spector M. Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro. Bone. 2005 Jan; 36(1):84-92. PMID: 15664006.
    Citations: 3     Fields:    Translation:AnimalsCells
  113. Saad L, Spector M. Effects of collagen type on the behavior of adult canine annulus fibrosus cells in collagen-glycosaminoglycan scaffolds. J Biomed Mater Res A. 2004 Nov 01; 71(2):233-41. PMID: 15368219.
    Citations: 11     Fields:    Translation:AnimalsCells
  114. Russlies M, Behrens P, Ehlers EM, Bröhl C, Vindigni C, Spector M, Kurz B. Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model. Cell Tissue Res. 2005 Jan; 319(1):133-42. PMID: 15517404.
    Citations: 6     Fields:    Translation:AnimalsCells
  115. Noordin S, Shortkroff S, Sledge CB, Spector M. Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates. Biomaterials. 2004 Oct; 25(23):5347-52. PMID: 15130719.
    Citations: 3     Fields:    Translation:Humans
  116. Porter AE, Taak P, Hobbs LW, Coathup MJ, Blunn GW, Spector M. Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy. Biomaterials. 2004 Sep; 25(21):5199-208. PMID: 15109844.
    Citations: 5     Fields:    Translation:Humans
  117. Mazzucco D, Scott R, Spector M. Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow properties. Biomaterials. 2004 Aug; 25(18):4433-45. PMID: 15046934.
    Citations: 20     Fields:    Translation:HumansCTClinical Trials
  118. Gordon TD, Schloesser L, Humphries DE, Spector M. Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro. Tissue Eng. 2004 Jul-Aug; 10(7-8):1287-95. PMID: 15363183.
    Citations: 1     Fields:    Translation:AnimalsCellsPHPublic Health
  119. Vickers SM, Johnson LL, Zou LQ, Yannas IV, Gibson LJ, Spector M. Expression of alpha-smooth muscle actin by and contraction of cells derived from synovium. Tissue Eng. 2004 Jul-Aug; 10(7-8):1214-23. PMID: 15363177.
    Citations: 4     Fields:    Translation:AnimalsCells
  120. Hastreiter D, Chao J, Wang Q, Ozuna RM, Spector M. Alpha-smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitro. Wound Repair Regen. 2004 Jul-Aug; 12(4):430-8. PMID: 15260808.
    Citations:    Fields:    Translation:Humans
  121. Zaleskas JM, Kinner B, Freyman TM, Yannas IV, Gibson LJ, Spector M. Contractile forces generated by articular chondrocytes in collagen-glycosaminoglycan matrices. Biomaterials. 2004 Mar-Apr; 25(7-8):1299-308. PMID: 14643604.
    Citations: 9     Fields:    Translation:AnimalsCells
  122. Pek YS, Spector M, Yannas IV, Gibson LJ. Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase. Biomaterials. 2004 Feb; 25(3):473-82. PMID: 14585696.
    Citations: 13     Fields:    Translation:Animals
  123. Harley BA, Spilker MH, Wu JW, Asano K, Hsu HP, Spector M, Yannas IV. Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cells Tissues Organs. 2004; 176(1-3):153-65. PMID: 14745243.
    Citations: 32     Fields:    Translation:AnimalsCells
  124. Veilleux NH, Yannas IV, Spector M. Effect of passage number and collagen type on the proliferative, biosynthetic, and contractile activity of adult canine articular chondrocytes in type I and II collagen-glycosaminoglycan matrices in vitro. Tissue Eng. 2004 Jan-Feb; 10(1-2):119-27. PMID: 15009937.
    Citations: 14     Fields:    Translation:AnimalsCells
  125. Pascher A, Palmer GD, Steinert A, Oligino T, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Gene delivery to cartilage defects using coagulated bone marrow aspirate. Gene Ther. 2004 Jan; 11(2):133-41. PMID: 14712297.
    Citations: 34     Fields:    Translation:AnimalsCells
  126. Frank E, Evans R, Lee C, Treppo S, Spector M, Grodzinsky A. Quantitative electrical impedance analysis of cartilage degradation. Biorheology. 2004; 41(3-4):195-202. PMID: 15299252.
    Citations: 2     Fields:    Translation:HumansAnimals
  127. Capito RM, Spector M. Scaffold-based articular cartilage repair. IEEE Eng Med Biol Mag. 2003 Sep-Oct; 22(5):42-50. PMID: 14699935.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  128. Hindman HB, Marty-Roix R, Tang JB, Jupiter JB, Simmons BP, Spector M. Regulation of expression of alpha-smooth muscle actin in cells of Dupuytren's contracture. J Bone Joint Surg Br. 2003 Apr; 85(3):448-55. PMID: 12729127.
    Citations: 5     Fields:    Translation:Humans
  129. Lee CR, Grodzinsky AJ, Spector M. Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. J Biomed Mater Res A. 2003 Mar 01; 64(3):560-9. PMID: 12579571.
    Citations: 18     Fields:    Translation:AnimalsCells
  130. Meaney Murray M, Rice K, Wright RJ, Spector M. The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res. 2003 Mar; 21(2):238-44. PMID: 12568954.
    Citations: 35     Fields:    Translation:HumansCells
  131. Lee CR, Grodzinsky AJ, Hsu HP, Spector M. Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. J Orthop Res. 2003 Mar; 21(2):272-81. PMID: 12568959.
    Citations: 23     Fields:    Translation:AnimalsCells
  132. Lee CR, Grodzinsky AJ, Spector M. Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices. Tissue Eng. 2003 Feb; 9(1):27-36. PMID: 12625951.