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profileMyron Spector, PH.D.

TitleProfessor of Orthopedic Surgery (Biomaterials)
InstitutionBrigham and Women's Hospital
DepartmentOrthopedic Surgery
AddressV.A. Medical Center - Boston
Tissue Engr/Orthopedic Surgery, MS151
150 S Huntington Ave
Jamaica Plain MA 02130
Phone857/364-6639
Fax857/364-6791
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Other Positions
TitleMember of the Faculty of the Harvard-MIT Health Sciences and Technology
InstitutionBrigham and Women's Hospital
DepartmentHealth Sciences and Technology


Collapse Biography 
Collapse awards and honors
2001Elizabeth Winston-Lanier Kappa Delta Award
2002Clemson Award for Applied Biomaterials Research
2002Research Career Scientist Award
2004John Charnley Award
2013Chandra P. Sharma Award

Collapse Overview 
Collapse overview
Director, Orthopaedic Research Laboratory, Brigham and Women's Hospital
Director, Tissue Engineering Laboratory, VA Boston Healthcare System
Senior Lecturer, Mechanical Engineering , MIT

Prof. Spector has been engaged in biomaterials research for over 30 years, and in tissue engineering studies for 15 years, employing animal models and cell culture systems. He is supervising investigations related to musculoskeletal and nerve regeneration, involving biopolymer sponge-like scaffolds and injectable gels. He recently has established projects demonstrating the potential of extracorporeal shock wave treatment to enhance the make-up of select tissues to be used as autografts for bone and cartilage repair.

Prof. Spector teaches 4 subjects at MIT: Biomaterial-Tissue Interactions (2.79J/3.96J/BEH.441HST 522J); Cell-Matrix Mechanics (2.785J/3.97J/20.411J/HST523J); Design of Medical Devices/Implants (2.782J/3.961J/20.451J/HST524J); and Principles and Practice of Tissue Engineering (HST.535). He is the principal research supervisor for students in: MIT doctoral programs; Harvard Medical School; and postgraduate programs at the Harvard School of Dental Medicine. His postdoctoral research fellows come with varied backgrounds from many countries.

Dr. Spector is a VA Research Career Scientist.

Other Positions:
2005-present: Co-Editor-in Chief, Biomedical Materials: Materials for Tissue Engineering & Regenerative Medicine
1993-1997: Chairman, Food and Drug Administration General and Plastic Surgery Devices Advisory Panel
1990-1991: President, Society for Biomaterials


Collapse Mentoring 
Collapse completed student projects
The Role of Lubricin in the Impaired Healing of Ruptured Ligaments and in the Therapeutic Treatment of Ligaments with Extracorporeal Shock Waves
Summer, 05/24/10 - 08/31/10
Contractile Behavior of Human Periodontal Ligament Fibroblasts in Collagen Matrices in vitro
Summer, 05/01/99 - 08/31/99
Regulation of Contractile Behavior of Fibroblasts in Inured Rotator Cuffs and Huypertrophic Scars
Part Time, 01/03/00 - 06/15/00
Tissue Engineering and Stem Cell Research
Summer, 07/01/03 - 08/31/03
The Identificaiton of Myofibroblast in Oral Lesions
Summer, 06/23/99 - 08/31/99
Contraction and Shrinkage of Collagen Matrices by Exogenous Cells from Ligament Extract
Part Time/Continuation, 01/01/99 - 06/18/99
Non-Viral Transfection of Caprine Mesenchymal Stem Cells with BMP-7 Plasmid: Effects of Plasmid Size and Type of Medium
Summer, 06/02/08 - 08/29/08
Mesenchymal stem cells on Type II collagen/GAG scaffolds for cartilage regeneration
Summer, 07/30/07 - 01/31/07

Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01AR040427     (SPECTOR, MYRON)Sep 20, 1991 - Aug 31, 1995
NIH/NIAMS
CALCIUM PHOSPHATE COATING FOR ORTHOPEDIC PROSTHESES
Role: Principal Investigator

R01DE006300     (SPECTOR, MYRON)Mar 1, 1982 - Jul 31, 1987
NIH/NIDCR
POROUS POLYETHYLENE AND POROUS POLYSULFONE TOOTH ROOTS
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Ambra LF, de Girolamo L, Niu W, Phan A, Spector M, Gomoll AH. No effect of topical application of tranexamic acid on articular cartilage. Knee Surg Sports Traumatol Arthrosc. 2017 Nov 08. PMID: 29119286.
    View in: PubMed
  2. Egawa N, Shindo A, Liang AC, Du Y, Xing C, Lo EK, Itoh K, Kinoshita H, Maki T, Takahashi R, Sudo R, Spector M, Lok J, Arai K. A Novel Three-Dimensional Culture System for Oligodendrocyte Precursor Cells. Stem Cells Dev. 2017 Jul 15; 26(14):1078-1085. PMID: 28446066.
    View in: PubMed
  3. Chan SJ, Love C, Spector M, Cool SM, Nurcombe V, Lo EH. Endogenous regeneration: Engineering growth factors for stroke. Neurochem Int. 2017 Jul; 107:57-65. PMID: 28411103.
    View in: PubMed
  4. Foldager CB, Bendtsen M, Berg LC, Brinchmann JE, Brittberg M, Bunger C, Canseco J, Chen L, Christensen BB, Colombier P, Deleuran BW, Edwards J, Elmengaard B, Farr J, Gatenholm B, Gomoll AH, Hui JH, Jakobsen RB, Joergensen NL, Kassem M, Koch T, Kold S, Krogsgaard MR, Lauridsen H, Le D, Le Visage C, Lind M, Nygaard JV, Olesen ML, Pedersen M, Rathcke M, Richardson JB, Roberts S, Rölfing JH, Sakai D, Toh WS, Urban J, Spector M. Aarhus Regenerative Orthopaedics Symposium (AROS). Acta Orthop. 2016 Dec; 87(sup363):1-5. PMID: 28271925.
    View in: PubMed
  5. Zhang Z, Li Z, Deng W, He Q, Wang Q, Shi W, Chen Q, Yang W, Spector M, Gong A, Yu J, Xu X. Ectoderm mesenchymal stem cells promote differentiation and maturation of oligodendrocyte precursor cells. Biochem Biophys Res Commun. 2016 Nov 25; 480(4):727-733. PMID: 27983986.
    View in: PubMed
  6. Spector M. An interview with Arthur J Coury: an extensively experienced perspective on medical device development. Biomed Mater. 2016 Oct 06; 11(5):050401. PMID: 27710920.
    View in: PubMed
  7. Toh WS, Brittberg M, Farr J, Foldager CB, Gomoll AH, Hui JH, Richardson JB, Roberts S, Spector M. Cellular senescence in aging and osteoarthritis. Acta Orthop. 2016 Dec; 87(sup363):6-14. PMID: 27658487.
    View in: PubMed
  8. Lim TC, Spector M. Biomaterials for Enhancing CNS Repair. Transl Stroke Res. 2017 Feb; 8(1):57-64. PMID: 27251413.
    View in: PubMed
  9. Spector M. The living legacy of a biomaterials founder: remembering Samuel F Hulbert, PhD. Biomed Mater. 2016 Mar 22; 11(2):020202. PMID: 27001792.
    View in: PubMed
  10. Spector M. Decellularized tissues and organs: an historical perspective and prospects for the future. Biomed Mater. 2016 Mar 17; 11(2):020201. PMID: 26989090.
    View in: PubMed
  11. Min J, Choi KY, Dreaden EC, Padera RF, Braatz RD, Spector M, Hammond PT. Designer Dual Therapy Nanolayered Implant Coatings Eradicate Biofilms and Accelerate Bone Tissue Repair. ACS Nano. 2016 04 26; 10(4):4441-50. PMID: 26923427.
    View in: PubMed
  12. Spector M, Lim TC. Injectable biomaterials: a perspective on the next wave of injectable therapeutics. Biomed Mater. 2016 Feb 02; 11(1):014110. PMID: 26836246.
    View in: PubMed
  13. Foldager CB, Toh WS, Christensen BB, Lind M, Gomoll AH, Spector M. Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects. Cartilage. 2016 Jan; 7(1):52-61. PMID: 26958317; PMCID: PMC4749752 [Available on 01/01/17].
  14. Toh WS, Foldager CB, Hui JH, Olsen BR, Spector M. Exploiting Stem Cell-Extracellular Matrix Interactions for Cartilage Regeneration: A Focus on Basement Membrane Molecules. Curr Stem Cell Res Ther. 2016; 11(8):618-625. PMID: 26201861.
    View in: PubMed
  15. Spector M. An auspicious decade for biomedical materials. Biomed Mater. 2015 Dec 23; 11(1):010201. PMID: 26693853.
    View in: PubMed
  16. Foldager CB, Nyengaard JR, Lind M, Spector M. A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue. Cartilage. 2015 Apr; 6(2):123-32. PMID: 26069715; PMCID: PMC4462253.
  17. Spector M. The CEO as a medical device 'translator': a remembrance of Peter Geistlich, PhD. Biomed Mater. 2014 Sep 27; 9(5):050401. PMID: 25262615.
    View in: PubMed
  18. Shah NJ, Hyder MN, Quadir MA, Dorval Courchesne NM, Seeherman HJ, Nevins M, Spector M, Hammond PT. Adaptive growth factor delivery from a polyelectrolyte coating promotes synergistic bone tissue repair and reconstruction. Proc Natl Acad Sci U S A. 2014 Sep 02; 111(35):12847-52. PMID: 25136093; PMCID: PMC4156697.
  19. Ying JY, Spector M. An interview with Jackie Yi-Ru Ying: the compleat multi-tasker. Biomed Mater. 2014 Jun; 9(3):030401. PMID: 24818688.
    View in: PubMed
  20. Foldager CB, Toh WS, Gomoll AH, Olsen BR, Spector M. Distribution of Basement Membrane Molecules, Laminin and Collagen Type IV, in Normal and Degenerated Cartilage Tissues. Cartilage. 2014 Apr; 5(2):123-32. PMID: 26069692; PMCID: PMC4297081.
  21. Johnson LL, Delano M, Spector M, Pittsley A, Gottschalk A. The Long-Term Clinical Outcomes Following Autogenous Bone Grafting for Large-Volume Defects of the Knee: 12- to 21-Year Follow-Up. Cartilage. 2014 Apr; 5(2):86-96. PMID: 26069688; PMCID: PMC4297077.
  22. Spector M. The tissue engineer's toolbox manifesto. Biomed Mater. 2014 Feb; 9(1):010201. PMID: 24457154.
    View in: PubMed
  23. Shoichet MS. An interview with Molly S Shoichet. Developing biomaterials and mobilizing resources for assaults on some of the most devastating medical problems by Myron Spector. Biomed Mater. 2013 Dec; 8(6):060401. PMID: 24287970.
    View in: PubMed
  24. Shah NJ, Hyder MN, Moskowitz JS, Quadir MA, Morton SW, Seeherman HJ, Padera RF, Spector M, Hammond PT. Surface-mediated bone tissue morphogenesis from tunable nanolayered implant coatings. Sci Transl Med. 2013 Jun 26; 5(191):191ra83. PMID: 23803705; PMCID: PMC4001255.
  25. Jeng L, Hsu HP, Spector M. Tissue-engineered cartilaginous constructs for the treatment of caprine cartilage defects, including distribution of laminin and type IV collagen. Tissue Eng Part A. 2013 Oct; 19(19-20):2267-74. PMID: 23672504; PMCID: PMC3761422.
  26. Lee IS, Spector M. 'What led you to do that?' And other questions for the leaders of our field: the BMM Interview. Biomed Mater. 2013 Aug; 8(4):040201. PMID: 23715035.
    View in: PubMed
  27. Yannas IV. An interview with I V Yannas. Tracing one of the deepest roots of biomaterials in tissue engineering/regenerative medicine. Interview by Myron Spector. Biomed Mater. 2013 Aug; 8(4):040401. PMID: 23715065.
    View in: PubMed
  28. Lee IS, Spector M. Biomedical materials and 2013. Biomed Mater. 2013 Apr; 8(2):020201. PMID: 23528391.
    View in: PubMed
  29. Toh WS, Foldager CB, Olsen BR, Spector M. Basement membrane molecule expression attendant to chondrogenesis by nucleus pulposus cells and mesenchymal stem cells. J Orthop Res. 2013 Jul; 31(7):1136-43. PMID: 23508654.
    View in: PubMed
  30. Wada K, Gerbaudo VH, Spector M. Effects of PDGF-BB and OP-1 on mesenchymal stem cells in a porous mineral block. Int J Periodontics Restorative Dent. 2013 Mar-Apr; 33(2):e72-8. PMID: 23484183.
    View in: PubMed
  31. Macaya DJ, Hayakawa K, Arai K, Spector M. Astrocyte infiltration into injectable collagen-based hydrogels containing FGF-2 to treat spinal cord injury. Biomaterials. 2013 May; 34(14):3591-602. PMID: 23414684.
    View in: PubMed
  32. Lim TC, Rokkappanavar S, Toh WS, Wang LS, Kurisawa M, Spector M. Chemotactic recruitment of adult neural progenitor cells into multifunctional hydrogels providing sustained SDF-1a release and compatible structural support. FASEB J. 2013 Mar; 27(3):1023-33. PMID: 23193174.
    View in: PubMed
  33. Lee IS, Spector M. The people behind the papers, and how much data is enough? Biomed Mater. 2012 Dec 1; 7(6):060201-60201. PMID: 23183909.
    View in: PubMed
  34. Cheriyan T, Ready JE, Brick GW, Martin SD, Martin TL, Schmid TM, Padera RF, Spector M. Lubricin and smooth muscle a-actin-containing myofibroblasts in the pseudomembranes around loose hip and knee prostheses. Acta Biomater. 2013 Mar; 9(3):5751-8. PMID: 23174700.
    View in: PubMed
  35. Elias PZ, Spector M. Treatment of penetrating brain injury in a rat model using collagen scaffolds incorporating soluble Nogo receptor. J Tissue Eng Regen Med. 2015 Feb; 9(2):137-50. PMID: 23038669.
    View in: PubMed
  36. Cholas R, Hsu HP, Spector M. Collagen scaffolds incorporating select therapeutic agents to facilitate a reparative response in a standardized hemiresection defect in the rat spinal cord. Tissue Eng Part A. 2012 Oct; 18(19-20):2158-72. PMID: 22827732.
    View in: PubMed
  37. Foldager CB, Kearney C, Spector M. Clinical application of extracorporeal shock wave therapy in orthopedics: focused versus unfocused shock waves. Ultrasound Med Biol. 2012 Oct; 38(10):1673-80. PMID: 22920552.
    View in: PubMed
  38. Cheriyan T, Guo L, Orgill DP, Padera RF, Schmid TM, Spector M. Lubricin in human breast tissue expander capsules. J Biomed Mater Res B Appl Biomater. 2012 Oct; 100(7):1961-9. PMID: 22865664.
    View in: PubMed
  39. Elias PZ, Spector M. Characterization of a bilateral penetrating brain injury in rats and evaluation of a collagen biomaterial for potential treatment. J Neurotrauma. 2012 Jul 20; 29(11):2086-102. PMID: 22519932.
    View in: PubMed
  40. Elias PZ, Spector M. Implantation of a collagen scaffold seeded with adult rat hippocampal progenitors in a rat model of penetrating brain injury. J Neurosci Methods. 2012 Jul 30; 209(1):199-211. PMID: 22698665.
    View in: PubMed
  41. Kearney CJ, Hsu HP, Spector M. The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation. Tissue Eng Part A. 2012 Jul; 18(13-14):1500-8. PMID: 22519654.
    View in: PubMed
  42. Zhang D, Cheriyan T, Martin SD, Schmid TM, Spector M. Lubricin Distribution in the Menisci and Labra of Human Osteoarthritic Joints. Cartilage. 2012 Apr; 3(2):165-72. PMID: 26069629; PMCID: PMC4297123.
  43. Foldager CB, Gomoll AH, Lind M, Spector M. Cell Seeding Densities in Autologous Chondrocyte Implantation Techniques for Cartilage Repair. Cartilage. 2012 Apr; 3(2):108-17. PMID: 26069624; PMCID: PMC4297130.
  44. Elias PZ, Spector M. Viscoelastic characterization of rat cerebral cortex and type I collagen scaffolds for central nervous system tissue engineering. J Mech Behav Biomed Mater. 2012 Aug; 12:63-73. PMID: 22659367.
    View in: PubMed
  45. Toh WS, Lim TC, Kurisawa M, Spector M. Modulation of mesenchymal stem cell chondrogenesis in a tunable hyaluronic acid hydrogel microenvironment. Biomaterials. 2012 May; 33(15):3835-45. PMID: 22369963.
    View in: PubMed
  46. Jeng L, Olsen BR, Spector M. Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels. Acta Biomater. 2012 Jul; 8(6):2203-12. PMID: 22370447.
    View in: PubMed
  47. Lim TC, Toh WS, Wang LS, Kurisawa M, Spector M. The effect of injectable gelatin-hydroxyphenylpropionic acid hydrogel matrices on the proliferation, migration, differentiation and oxidative stress resistance of adult neural stem cells. Biomaterials. 2012 Apr; 33(12):3446-55. PMID: 22306021.
    View in: PubMed
  48. Lee IS, Spector M. Coping with copying and conflicts (of interest). Biomed Mater. 2012 Feb; 7(1):010201. PMID: 22287538.
    View in: PubMed
  49. Johnson LL, DeLano MC, Spector M, Jeng L, Pittsley A, Gottschalk A. The Biological Response following Autogenous Bone Grafting for Large-Volume Defects of the Knee: Index Surgery through 12 to 21 Years' Follow-up. Cartilage. 2012 Jan; 3(1):86-99. PMID: 26069622; PMCID: PMC4297185.
  50. Cholas RH, Hsu HP, Spector M. The reparative response to cross-linked collagen-based scaffolds in a rat spinal cord gap model. Biomaterials. 2012 Mar; 33(7):2050-9. PMID: 22182744.
    View in: PubMed
  51. Cheriyan T, Schmid TM, Spector M. Presence and distribution of the lubricating protein, lubricin, in the meibomian gland in rabbits. Mol Vis. 2011; 17:3055-61. PMID: 22162624; PMCID: PMC3233388.
  52. Zhang D, Kearney CJ, Cheriyan T, Schmid TM, Spector M. Extracorporeal shockwave-induced expression of lubricin in tendons and septa. Cell Tissue Res. 2011 Nov; 346(2):255-62. PMID: 22009294.
    View in: PubMed
  53. Ng KK, Thatte HS, Spector M. Chondrogenic differentiation of adult mesenchymal stem cells and embryonic cells in collagen scaffolds. J Biomed Mater Res A. 2011 Nov; 99(2):275-82. PMID: 21858916.
    View in: PubMed
  54. Zhang D, Cheriyan T, Martin SD, Gomoll AH, Schmid TM, Spector M. Lubricin distribution in the torn human anterior cruciate ligament and meniscus. J Orthop Res. 2011 Dec; 29(12):1916-22. PMID: 21647956.
    View in: PubMed
  55. Toh WS, Spector M, Lee EH, Cao T. Biomaterial-mediated delivery of microenvironmental cues for repair and regeneration of articular cartilage. Mol Pharm. 2011 Aug 01; 8(4):994-1001. PMID: 21500855.
    View in: PubMed
  56. Kearney CJ, Lee JY, Padera RF, Hsu HP, Spector M. Extracorporeal shock wave-induced proliferation of periosteal cells. J Orthop Res. 2011 Oct; 29(10):1536-43. PMID: 21448986.
    View in: PubMed
  57. Krevolin J, Liu JJ, Wallen A, Patel K, Dahl R, Hsu H-P, Kearney C, Spector M. Proceedings of the 35th Int. Conf on Advanced Ceramics and Composites. Tissue ingrowth in resorbable porous tissue scaffolds. 2011.
  58. Perez RA, Ginebra MP, and Spector M. J. Materials Sci. Mater. in Med. Cell response to collagen-calcium phosphate cement scaffolds investigated for nonviral gene delivery. 2011; 22:887-897.
  59. Johnson LJ, Verioti C, Gelber C, Spector M, and D’Lima D. The Knee. The pathology of the end stage osteoarthritic lesion of the knee: Potential role in cartilage repair. 2011; 18:402-6.
  60. Johnson LL, Verioti C, Gelber J, Spector M, D'Lima D, Pittsley A. The pathology of the end-stage osteoarthritic lesion of the knee: potential role in cartilage repair. Knee. 2011 Dec; 18(6):402-6. PMID: 20934341.
    View in: PubMed
  61. Jeng L, Olsen BR, Spector M. Engineering endostatin-producing cartilaginous constructs for cartilage repair using nonviral transfection of chondrocyte-seeded and mesenchymal-stem-cell-seeded collagen scaffolds. Tissue Eng Part A. 2010 Oct; 16(10):3011-21. PMID: 20545556; PMCID: PMC3189205.
  62. Vickers SM, Gotterbarm T, Spector M. Cross-linking affects cellular condensation and chondrogenesis in type II collagen-GAG scaffolds seeded with bone marrow-derived mesenchymal stem cells. J Orthop Res. 2010 Sep; 28(9):1184-92. PMID: 20225321.
    View in: PubMed
  63. Zhang L, Spector M. Synovium tissue engineering to prevent tendon sheath adhesion. Plast Reconstr Surg. 2010 Jul; 126(1):44e-45e. PMID: 20595850.
    View in: PubMed
  64. Funakoshi T, Spector M. Chondrogenic differentiation and lubricin expression of caprine infraspinatus tendon cells. J Orthop Res. 2010 Jun; 28(6):716-25. PMID: 20058273.
    View in: PubMed
  65. Moskowitz JS, Blaisse MR, Samuel RE, Hsu HP, Harris MB, Martin SD, Lee JC, Spector M, Hammond PT. The effectiveness of the controlled release of gentamicin from polyelectrolyte multilayers in the treatment of Staphylococcus aureus infection in a rabbit bone model. Biomaterials. 2010 Aug; 31(23):6019-30. PMID: 20488534; PMCID: PMC2913156.
  66. Funakoshi T, Martin SD, Wolf BT, Schmid TM, Thornhill TS, Spector M. alpha-Smooth muscle actin-expressing cells and lubricin in periprosthetic tissue. J Biomed Mater Res A. 2010 May; 93(2):515-27. PMID: 19585565.
    View in: PubMed
  67. Kobayashi M, Spector M. In vitro response of the bone marrow-derived mesenchymal stem cells seeded in a type-I collagen-glycosaminoglycan scaffold for skin wound repair under the mechanical loading condition. Mol Cell Biomech. 2009 Dec; 6(4):217-27. PMID: 19899445.
    View in: PubMed
  68. Funakoshi T, Martin SD, Schmid TM, Spector M. Distribution of lubricin in the ruptured human rotator cuff and biceps tendon: a pilot study. Clin Orthop Relat Res. 2010 Jun; 468(6):1588-99. PMID: 19798542; PMCID: PMC2865589.
  69. Shine KM, Simson JA, Spector M. Lubricin distribution in the human intervertebral disc. J Bone Joint Surg Am. 2009 Sep; 91(9):2205-12. PMID: 19723998.
    View in: PubMed
  70. Zhang L, Spector M. Comparison of three types of chondrocytes in collagen scaffolds for cartilage tissue engineering. Biomed Mater. 2009 Aug; 4(4):045012. PMID: 19636108.
    View in: PubMed
  71. Wang TW, Spector M. Development of hyaluronic acid-based scaffolds for brain tissue engineering. Acta Biomater. 2009 Sep; 5(7):2371-84. PMID: 19403351.
    View in: PubMed
  72. Wu H-C, Wang T-W, Bohn MC, Lin F-H, and Spector M. Advanced Functional Materials. Novel magnetic hydroxyapatite nanoparticles as non-viral vectors for the glial cell line-derived neurotrophic factor gene. 2009; 19:1-11.
  73. Sun XD, Jeng L, Bolliet C, Olsen BR, Spector M. Non-viral endostatin plasmid transfection of mesenchymal stem cells via collagen scaffolds. Biomaterials. 2009 Feb; 30(6):1222-31. PMID: 19059640.
    View in: PubMed
  74. Shine KM, Spector M. The presence and distribution of lubricin in the caprine intervertebral disc. J Orthop Res. 2008 Oct; 26(10):1398-406. PMID: 18464265.
    View in: PubMed
  75. Bolliet C, Bohn MC, Spector M. Non-viral delivery of the gene for glial cell line-derived neurotrophic factor to mesenchymal stem cells in vitro via a collagen scaffold. Tissue Eng Part C Methods. 2008 Sep; 14(3):207-19. PMID: 18721070.
    View in: PubMed
  76. Spector M. Ideas and inspiration: a remembrance of Philip J Boyne, DMD, MS, DSc. Biomed Mater. 2008 Sep; 3(3):030401. PMID: 18591731.
    View in: PubMed
  77. Madaghiele M, Sannino A, Yannas IV, Spector M. Collagen-based matrices with axially oriented pores. J Biomed Mater Res A. 2008 Jun 01; 85(3):757-67. PMID: 17896767.
    View in: PubMed
  78. Funakoshi T, Schmid T, Hsu HP, Spector M. Lubricin distribution in the goat infraspinatus tendon: a basis for interfascicular lubrication. J Bone Joint Surg Am. 2008 Apr; 90(4):803-14. PMID: 18381319.
    View in: PubMed
  79. Xu X, Capito RM, Spector M. Plasmid size influences chitosan nanoparticle mediated gene transfer to chondrocytes. J Biomed Mater Res A. 2008 Mar 15; 84(4):1038-48. PMID: 17685397.
    View in: PubMed
  80. Pfeiffer E, Vickers SM, Frank E, Grodzinsky AJ, and Spector M. Osteoarth. and Cart. The effects of glycosaminoglycan content on the compressive modulus of cartilage engineered in type II collagen scaffolds. 2008; 16:1237-1244.
  81. Xu X, Capito RM, Spector M. Delivery of plasmid IGF-1 to chondrocytes via cationized gelatin nanoparticles. J Biomed Mater Res A. 2008 Jan; 84(1):73-83. PMID: 17600330.
    View in: PubMed
  82. Ma J, Tian WM, Hou SP, Xu QY, Spector M, Cui FZ. An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. Biomed Mater. 2007 Dec; 2(4):233-40. PMID: 18458480.
    View in: PubMed
  83. Steinert AF, Palmer GD, Capito R, Hofstaetter JG, Pilapil C, Ghivizzani SC, Spector M, Evans CH. Genetically enhanced engineering of meniscus tissue using ex vivo delivery of transforming growth factor-beta 1 complementary deoxyribonucleic acid. Tissue Eng. 2007 Sep; 13(9):2227-37. PMID: 17561802.
    View in: PubMed
  84. Tang S, Vickers SM, Hsu HP, Spector M. Fabrication and characterization of porous hyaluronic acid-collagen composite scaffolds. J Biomed Mater Res A. 2007 Aug; 82(2):323-35. PMID: 17295240.
    View in: PubMed
  85. Tang S, Spector M. Incorporation of hyaluronic acid into collagen scaffolds for the control of chondrocyte-mediated contraction and chondrogenesis. Biomed Mater. 2007 Sep; 2(3):S135-41. PMID: 18458458.
    View in: PubMed
  86. Zhang D, Johnson LJ, Hsu HP, Spector M. Cartilaginous deposits in subchondral bone in regions of exposed bone in osteoarthritis of the human knee: histomorphometric study of PRG4 distribution in osteoarthritic cartilage. J Orthop Res. 2007 Jul; 25(7):873-83. PMID: 17343281.
    View in: PubMed
  87. Spector M. Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2007 Mar 02; 137 Suppl 155:157S-165S. PMID: 17874524.
    View in: PubMed
  88. Ma J, Tian W-M, Hou S-P, Xu Q-Y, Spector M, and Cui F-Z. Biomed. Mater.: Mater. in Tissue Engr. and Regen. Med. An experimental test of stroke recovery by implanting a hyaluronic acid hydrogel carrying a Nogo receptor antibody in a rat model. 2007; 2:233-240.
  89. Hunziker E, Spector M, Libera J, Gertzman A, Woo SL, Ratcliffe A, Lysaght M, Coury A, Kaplan D, Vunjak-Novakovic G. Translation from research to applications. Tissue Eng. 2006 Dec; 12(12):3341-64. PMID: 17518672.
    View in: PubMed
  90. Xiang Z, Liao R, Kelly MS, Spector M. Collagen-GAG scaffolds grafted onto myocardial infarcts in a rat model: a delivery vehicle for mesenchymal stem cells. Tissue Eng. 2006 Sep; 12(9):2467-78. PMID: 16995780.
    View in: PubMed
  91. Spector M. Biomaterials-based tissue engineering and regenerative medicine solutions to musculoskeletal problems. Swiss Med Wkly. 2006 May 13; 136(19-20):293-301. PMID: 16741852.
    View in: PubMed
  92. Sun W, Yan Y, Lin F, Spector M. Biomanufacturing: a US-China National Science Foundation-sponsored workshop. Tissue Eng. 2006 May; 12(5):1169-81. PMID: 16771632.
    View in: PubMed
  93. Vickers SM, Squitieri LS, Spector M. Effects of cross-linking type II collagen-GAG scaffolds on chondrogenesis in vitro: dynamic pore reduction promotes cartilage formation. Tissue Eng. 2006 May; 12(5):1345-55. PMID: 16771647.
    View in: PubMed
  94. Wang H, Eliaz N, Xiang Z, Hsu HP, Spector M, Hobbs LW. Early bone apposition in vivo on plasma-sprayed and electrochemically deposited hydroxyapatite coatings on titanium alloy. Biomaterials. 2006 Aug; 27(23):4192-203. PMID: 16618502.
    View in: PubMed
  95. Mazzucco, D and Spector, M. J. Tribology. Contact area as a critical determinant in the tribology of metal-on-polyethylene total joint arthroplasty. 2006; 128:113-121.
  96. Chen P, Marsilio E, Goldstein RH, Yannas IV, Spector M. Formation of lung alveolar-like structures in collagen-glycosaminoglycan scaffolds in vitro. Tissue Eng. 2005 Sep-Oct; 11(9-10):1436-48. PMID: 16259599.
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  97. Mazzucco D, Spector M. The John Charnley Award Paper. The role of joint fluid in the tribology of total joint arthroplasty. Clin Orthop Relat Res. 2004 Dec; (429):17-32. PMID: 15577461.
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  98. Wang H, Gerbaudo VH, Hobbs LW, Spector M. Quantitation of osteoblast-like cell mineralization on tissue culture polystyrene and Ti-6Al-4V alloy disks by Tc-99m-MDP labeling and imaging in vitro. Bone. 2005 Jan; 36(1):84-92. PMID: 15664006.
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  99. Saad L, Spector M. Effects of collagen type on the behavior of adult canine annulus fibrosus cells in collagen-glycosaminoglycan scaffolds. J Biomed Mater Res A. 2004 Nov 01; 71(2):233-41. PMID: 15368219.
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  100. Russlies M, Behrens P, Ehlers EM, Bröhl C, Vindigni C, Spector M, Kurz B. Periosteum stimulates subchondral bone densification in autologous chondrocyte transplantation in a sheep model. Cell Tissue Res. 2005 Jan; 319(1):133-42. PMID: 15517404.
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  101. Noordin S, Shortkroff S, Sledge CB, Spector M. Investigation of the activation of a human serum complement protein, C3, by orthopedic prosthetic particulates. Biomaterials. 2004 Oct; 25(23):5347-52. PMID: 15130719.
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  102. Porter AE, Taak P, Hobbs LW, Coathup MJ, Blunn GW, Spector M. Bone bonding to hydroxyapatite and titanium surfaces on femoral stems retrieved from human subjects at autopsy. Biomaterials. 2004 Sep; 25(21):5199-208. PMID: 15109844.
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  103. Mazzucco D, Scott R, Spector M. Composition of joint fluid in patients undergoing total knee replacement and revision arthroplasty: correlation with flow properties. Biomaterials. 2004 Aug; 25(18):4433-45. PMID: 15046934.
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  104. Gordon TD, Schloesser L, Humphries DE, Spector M. Effects of the degradation rate of collagen matrices on articular chondrocyte proliferation and biosynthesis in vitro. Tissue Eng. 2004 Jul-Aug; 10(7-8):1287-95. PMID: 15363183.
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  105. Vickers SM, Johnson LL, Zou LQ, Yannas IV, Gibson LJ, Spector M. Expression of alpha-smooth muscle actin by and contraction of cells derived from synovium. Tissue Eng. 2004 Jul-Aug; 10(7-8):1214-23. PMID: 15363177.
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  106. Hastreiter D, Chao J, Wang Q, Ozuna RM, Spector M. Alpha-smooth muscle actin in pathological human disc nucleus pulposus cells in vivo and in vitro. Wound Repair Regen. 2004 Jul-Aug; 12(4):430-8. PMID: 15260808.
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  107. Zaleskas JM, Kinner B, Freyman TM, Yannas IV, Gibson LJ, Spector M. Contractile forces generated by articular chondrocytes in collagen-glycosaminoglycan matrices. Biomaterials. 2004 Mar-Apr; 25(7-8):1299-308. PMID: 14643604.
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  108. Pek YS, Spector M, Yannas IV, Gibson LJ. Degradation of a collagen-chondroitin-6-sulfate matrix by collagenase and by chondroitinase. Biomaterials. 2004 Feb; 25(3):473-82. PMID: 14585696.
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  109. Harley BA, Spilker MH, Wu JW, Asano K, Hsu HP, Spector M, Yannas IV. Optimal degradation rate for collagen chambers used for regeneration of peripheral nerves over long gaps. Cells Tissues Organs. 2004; 176(1-3):153-65. PMID: 14745243.
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  110. Veilleux NH, Yannas IV, Spector M. Effect of passage number and collagen type on the proliferative, biosynthetic, and contractile activity of adult canine articular chondrocytes in type I and II collagen-glycosaminoglycan matrices in vitro. Tissue Eng. 2004 Jan-Feb; 10(1-2):119-27. PMID: 15009937.
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  111. Pascher A, Palmer GD, Steinert A, Oligino T, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Gene delivery to cartilage defects using coagulated bone marrow aspirate. Gene Ther. 2004 Jan; 11(2):133-41. PMID: 14712297.
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  112. Frank E, Evans R, Lee C, Treppo S, Spector M, Grodzinsky A. Quantitative electrical impedance analysis of cartilage degradation. Biorheology. 2004; 41(3-4):195-202. PMID: 15299252.
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  113. Capito RM, Spector M. Scaffold-based articular cartilage repair. IEEE Eng Med Biol Mag. 2003 Sep-Oct; 22(5):42-50. PMID: 14699935.
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  114. Hindman HB, Marty-Roix R, Tang JB, Jupiter JB, Simmons BP, Spector M. Regulation of expression of alpha-smooth muscle actin in cells of Dupuytren's contracture. J Bone Joint Surg Br. 2003 Apr; 85(3):448-55. PMID: 12729127.
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  115. Lee CR, Grodzinsky AJ, Spector M. Biosynthetic response of passaged chondrocytes in a type II collagen scaffold to mechanical compression. J Biomed Mater Res A. 2003 Mar 01; 64(3):560-9. PMID: 12579571.
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  116. Meaney Murray M, Rice K, Wright RJ, Spector M. The effect of selected growth factors on human anterior cruciate ligament cell interactions with a three-dimensional collagen-GAG scaffold. J Orthop Res. 2003 Mar; 21(2):238-44. PMID: 12568954.
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  117. Lee CR, Grodzinsky AJ, Hsu HP, Spector M. Effects of a cultured autologous chondrocyte-seeded type II collagen scaffold on the healing of a chondral defect in a canine model. J Orthop Res. 2003 Mar; 21(2):272-81. PMID: 12568959.
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  118. Lee CR, Grodzinsky AJ, Spector M. Modulation of the contractile and biosynthetic activity of chondrocytes seeded in collagen-glycosaminoglycan matrices. Tissue Eng. 2003 Feb; 9(1):27-36. PMID: 12625951.
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  119. Marty-Roix R, Bartlett JD, Spector M. Growth of porcine enamel-, dentin-, and cementum-derived cells in collagen-glycosaminoglycan matrices in vitro: expression of alpha-smooth muscle actin and contraction. Tissue Eng. 2003 Feb; 9(1):175-86. PMID: 12625966.
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  120. Kinner B, Pacicca DM, Gerstenfeld LC, Lee CA, Einhorn TA, Spector M. Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model. J Orthop Res. 2003 Jan; 21(1):20-7. PMID: 12507576.
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  121. Rong Y, Sugumaran G, Silbert JE, Spector M. Proteoglycans synthesized by canine intervertebral disc cells grown in a type I collagen-glycosaminoglycan matrix. Tissue Eng. 2002 Dec; 8(6):1037-47. PMID: 12542949.
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  122. Mazzucco D, McKinley G, Scott RD, Spector M. Rheology of joint fluid in total knee arthroplasty patients. J Orthop Res. 2002 Nov; 20(6):1157-63. PMID: 12472223.
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  123. Kinner B, Zaleskas JM, Spector M. Regulation of smooth muscle actin expression and contraction in adult human mesenchymal stem cells. Exp Cell Res. 2002 Aug 01; 278(1):72-83. PMID: 12126959.
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  124. Murray MM, Bennett R, Zhang X, Spector M. Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. J Orthop Res. 2002 Jul; 20(4):875-80. PMID: 12168681.
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  125. Lin BY, Richmond JC, Spector M. Contractile actin expression in torn human menisci. Wound Repair Regen. 2002 Jul-Aug; 10(4):259-66. PMID: 12191009.
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  126. Spector M. Novel cell-scaffold interactions encountered in tissue engineering: contractile behavior of musculoskeletal connective tissue cells. Tissue Eng. 2002 Jul; 8(3):351-7. PMID: 12167222.
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  127. Kinner B, Gerstenfeld LC, Einhorn TA, Spector M. Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model. Bone. 2002 May; 30(5):738-45. PMID: 11996913.
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  128. Kinner B, Spector M. Expression of smooth muscle actin in osteoblasts in human bone. J Orthop Res. 2002 May; 20(3):622-32. PMID: 12038640.
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  129. Samuel RE, Lee CR, Ghivizzani SC, Evans CH, Yannas IV, Olsen BR, Spector M. Delivery of plasmid DNA to articular chondrocytes via novel collagen-glycosaminoglycan matrices. Hum Gene Ther. 2002 May 01; 13(7):791-802. PMID: 11975846.
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  130. Xiang Z, Spector M. A glimpse of tissue engineering in China. Tissue Eng. 2002 Apr; 8(2):169-74. PMID: 12031107.
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  131. Brock DP, Marty-Roix R, Spector M. Alpha-smooth-muscle actin in and contraction of porcine dental pulp cells. J Dent Res. 2002 Mar; 81(3):203-8. PMID: 11876276.
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  132. Porter AE, Hobbs LW, Rosen VB, Spector M. The ultrastructure of the plasma-sprayed hydroxyapatite-bone interface predisposing to bone bonding. Biomaterials. 2002 Feb; 23(3):725-33. PMID: 11771693.
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  133. Rosen VB, Hobbs LW, Spector M. The ultrastructure of anorganic bovine bone and selected synthetic hyroxyapatites used as bone graft substitute materials. Biomaterials. 2002 Feb; 23(3):921-8. PMID: 11771712.
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  134. Grottkau BE, Noordin S, Shortkroff S, Schaffer JL, Thornhill TS, Spector M. Effect of mechanical perturbation on the release of PGE(2) by macrophages in vitro. J Biomed Mater Res. 2002 Feb; 59(2):288-93. PMID: 11745565.
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  135. Palmer G, Pascher A, Gouze E, Gouze JN, Betz O, Spector M, Robbins PD, Evans CH, Ghivizzani SC. Development of gene-based therapies for cartilage repair. Crit Rev Eukaryot Gene Expr. 2002; 12(4):259-73. PMID: 12641395.
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  136. Cai D, Marty-Roix R, Hsu HP, Spector M. Lapine and canine bone marrow stromal cells contain smooth muscle actin and contract a collagen-glycosaminoglycan matrix. Tissue Eng. 2001 Dec; 7(6):829-41. PMID: 11749738.
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  137. Lee CR, Grodzinsky AJ, Spector M. The effects of cross-linking of collagen-glycosaminoglycan scaffolds on compressive stiffness, chondrocyte-mediated contraction, proliferation and biosynthesis. Biomaterials. 2001 Dec; 22(23):3145-54. PMID: 11603587.
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  138. Benz EB, Federman M, Godleski JJ, Bierbaum BE, Thornhill TS, Spector M. Transmission electron microscopy of intracellular particles of polyethylene from joint replacement prostheses: size distribution and cellular response. Biomaterials. 2001 Nov; 22(21):2835-42. PMID: 11561888.
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  139. Zaleskas JM, Kinner B, Freyman TM, Yannas IV, Gibson LJ, Spector M. Growth factor regulation of smooth muscle actin expression and contraction of human articular chondrocytes and meniscal cells in a collagen-GAG matrix. Exp Cell Res. 2001 Oct 15; 270(1):21-31. PMID: 11597124.
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  140. Breinan HA, Hsu HP, Spector M. Chondral defects in animal models: effects of selected repair procedures in canines. Clin Orthop Relat Res. 2001 Oct; (391 Suppl):S219-30. PMID: 11603706.
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  141. Comut AA, Weber HP, Shortkroff S, Cui FZ, Spector M. Connective tissue orientation around dental implants in a canine model. Clin Oral Implants Res. 2001 Oct; 12(5):433-40. PMID: 11564102.
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  142. Murray MM, Spector M. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials. 2001 Sep; 22(17):2393-402. PMID: 11511036.
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  143. Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M. Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res. 2001 Jul; 19(4):659-64. PMID: 11518276.
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  144. Hastreiter D, Ozuna RM, Spector M. Regional variations in certain cellular characteristics in human lumbar intervertebral discs, including the presence of alpha-smooth muscle actin. J Orthop Res. 2001 Jul; 19(4):597-604. PMID: 11518268.
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  145. Orr TE, Villars PA, Mitchell SL, Hsu HP, Spector M. Compressive properties of cancellous bone defects in a rabbit model treated with particles of natural bone mineral and synthetic hydroxyapatite. Biomaterials. 2001 Jul; 22(14):1953-9. PMID: 11426873.
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  146. Spilker MH, Asano K, Yannas IV, Spector M. Contraction of collagen-glycosaminoglycan matrices by peripheral nerve cells in vitro. Biomaterials. 2001 May; 22(10):1085-93. PMID: 11352089.
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  147. Breinan HA, Minas T, Hsu HP, Nehrer S, Shortkroff S, Spector M. Autologous chondrocyte implantation in a canine model: change in composition of reparative tissue with time. J Orthop Res. 2001 May; 19(3):482-92. PMID: 11398864.
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  148. Kinner B, Spector M. Smooth muscle actin expression by human articular chondrocytes and their contraction of a collagen-glycosaminoglycan matrix in vitro. J Orthop Res. 2001 Mar; 19(2):233-41. PMID: 11347696.
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  149. Premdas J, Tang JB, Warner JP, Murray MM, Spector M. The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res. 2001 Mar; 19(2):221-8. PMID: 11347694.
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  150. Spector BM, Ries MD, Bourne RB, Sauer WS, Long M, Hunter G. Wear performance of ultra-high molecular weight polyethylene on oxidized zirconium total knee femoral components. J Bone Joint Surg Am. 2001; 83-A Suppl 2 Pt 2:80-6. PMID: 11712839.
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  151. Spilker MH, Yannas IV, Kostyk SK, Norregaard TV, Hsu HP, Spector M. The effects of tubulation on healing and scar formation after transection of the adult rat spinal cord. Restor Neurol Neurosci. 2001; 18(1):23-38. PMID: 11673667.
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  152. Spector M. Musculoskeletal connective tissue cells with muscle: expression of muscle actin in and contraction of fibroblasts, chondrocytes, and osteoblasts. Wound Repair Regen. 2001 Jan-Feb; 9(1):11-8. PMID: 11350635.
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  153. Lee CR, Breinan HA, Nehrer S, Spector M. Articular cartilage chondrocytes in type I and type II collagen-GAG matrices exhibit contractile behavior in vitro. Tissue Eng. 2000 Oct; 6(5):555-65. PMID: 11074941.
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  154. Murray MM, Martin SD, Martin TL, Spector M. Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am. 2000 Oct; 82-A(10):1387-97. PMID: 11057466.
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  155. Breinan HA, Martin SD, Hsu HP, Spector M. Healing of canine articular cartilage defects treated with microfracture, a type-II collagen matrix, or cultured autologous chondrocytes. J Orthop Res. 2000 Sep; 18(5):781-9. PMID: 11117301.
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  156. Menard C, Mitchell S, Spector M. Contractile behavior of smooth muscle actin-containing osteoblasts in collagen-GAG matrices in vitro: implant-related cell contraction. Biomaterials. 2000 Sep; 21(18):1867-77. PMID: 10919690.
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  157. Kim AC, Spector M. Distribution of chondrocytes containing alpha-smooth muscle actin in human articular cartilage. J Orthop Res. 2000 Sep; 18(5):749-55. PMID: 11117296.
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  158. Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M. Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Wound Repair Regen. 2000 Sep-Oct; 8(5):383-91. PMID: 11115150.
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  159. Comu AA, Shortkroff S, Zhang X, Spector M. Association of fibroblast orientation around titanium in vitro with expression of a muscle actin. Biomaterials. 2000 Sep; 21(18):1887-96. PMID: 10919692.
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  160. Lee CR, Grodzinsky AJ, Hsu HP, Martin SD, Spector M. Effects of harvest and selected cartilage repair procedures on the physical and biochemical properties of articular cartilage in the canine knee. J Orthop Res. 2000 Sep; 18(5):790-9. PMID: 11117302.
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  161. Torres DS, Freyman TM, Yannas IV, Spector M. Tendon cell contraction of collagen-GAG matrices in vitro: effect of cross-linking. Biomaterials. 2000 Aug; 21(15):1607-19. PMID: 10885733.
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  162. Murray MM, Martin SD, Spector M. Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res. 2000 Jul; 18(4):557-64. PMID: 11052491.
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  163. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz GR, Spector M. Near-terminus axonal structure and function following rat sciatic nerve regeneration through a collagen-GAG matrix in a ten-millimeter gap. J Neurosci Res. 2000 Jun 01; 60(5):666-77. PMID: 10820438.
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  164. Lucas RL, Lostroh CP, DiRusso CC, Spector MP, Wanner BL, Lee CA. Multiple factors independently regulate hilA and invasion gene expression in Salmonella enterica serovar typhimurium. J Bacteriol. 2000 Apr; 182(7):1872-82. PMID: 10714991; PMCID: PMC101869.
  165. Wang Q, Breinan HA, Hsu HP, Spector M. Healing of defects in canine articular cartilage: distribution of nonvascular alpha-smooth muscle actin-containing cells. Wound Repair Regen. 2000 Mar-Apr; 8(2):145-58. PMID: 10810041.
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  166. Chamberlain LJ, Yannas IV, Hsu HP, Spector M. Connective tissue response to tubular implants for peripheral nerve regeneration: the role of myofibroblasts. J Comp Neurol. 2000 Feb 21; 417(4):415-30. PMID: 10701864.
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  167. Spector MS, Heiney PA, Naciri J, Weslowski BT, Holt DB, Shashidhar R. Electroclinic liquid crystals with large induced tilt angle and small layer contraction Phys Rev E Stat Phys Plasmas Fluids Relat Interdiscip Topics. 2000 Feb; 61(2):1579-84. PMID: 11046440.
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  168. Spector MP, Garcia del Portillo F, Bearson SM, Mahmud A, Magut M, Finlay BB, Dougan G, Foster JW, Pallen MJ. The rpoS-dependent starvation-stress response locus stiA encodes a nitrate reductase (narZYWV) required for carbon-starvation-inducible thermotolerance and acid tolerance in Salmonella typhimurium. Microbiology. 1999 Nov; 145 ( Pt 11):3035-45. PMID: 10589711.
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  169. Nehrer S, Spector M, Minas T. Histologic analysis of tissue after failed cartilage repair procedures. Clin Orthop Relat Res. 1999 Aug; (365):149-62. PMID: 10627699.
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  170. Mueller SM, Schneider TO, Shortkroff S, Breinan HA, Spector M. alpha-smooth muscle actin and contractile behavior of bovine meniscus cells seeded in type I and type II collagen-GAG matrices. J Biomed Mater Res. 1999 Jun 05; 45(3):157-66. PMID: 10397971.
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  171. Mueller SM, Shortkroff S, Schneider TO, Breinan HA, Yannas IV, Spector M. Meniscus cells seeded in type I and type II collagen-GAG matrices in vitro. Biomaterials. 1999 Apr; 20(8):701-9. PMID: 10353653.
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  172. Orr TE, Patel AM, Wong B, Hatzigiannis GP, Minas T, Spector M. Attachment of periosteal grafts to articular cartilage with fibrin sealant. J Biomed Mater Res. 1999 Mar 05; 44(3):308-13. PMID: 10397933.
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  173. Schneider TO, Mueller SM, Shortkroff S, Spector M. Expression of alpha-smooth muscle actin in canine intervertebral disc cells in situ and in collagen-glycosaminoglycan matrices in vitro. J Orthop Res. 1999 Mar; 17(2):192-9. PMID: 10221835.
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  174. Lalor PA, Namba R, Mitchell SL, Bearcroff J, Beals N, Sledge CB, Spector M. Migration of polyethylene particles around stable implants in an animal model. J Long Term Eff Med Implants. 1999; 9(4):261-72. PMID: 10847967.
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  175. Murray MM, Spector M. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res. 1999 Jan; 17(1):18-27. PMID: 10073643.
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  176. Spector MP, DiRusso CC, Pallen MJ, Garcia del Portillo F, Dougan G, Finlay BB. The medium-/long-chain fatty acyl-CoA dehydrogenase (fadF) gene of Salmonella typhimurium is a phase 1 starvation-stress response (SSR) locus. Microbiology. 1999 Jan; 145 ( Pt 1):15-31. PMID: 10206693.
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  177. Nehrer S, Breinan HA, Ramappa A, Hsu HP, Minas T, Shortkroff S, Sledge CB, Yannas IV, Spector M. Chondrocyte-seeded collagen matrices implanted in a chondral defect in a canine model. Biomaterials. 1998 Dec; 19(24):2313-28. PMID: 9884045.
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  178. Chamberlain LJ, Yannas IV, Hsu HP, Strichartz G, Spector M. Collagen-GAG substrate enhances the quality of nerve regeneration through collagen tubes up to level of autograft. Exp Neurol. 1998 Dec; 154(2):315-29. PMID: 9878170.
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  179. Chamberlain LJ, Yannas IV, Arrizabalaga A, Hsu HP, Norregaard TV, Spector M. Early peripheral nerve healing in collagen and silicone tube implants: myofibroblasts and the cellular response. Biomaterials. 1998 Aug; 19(15):1393-403. PMID: 9758039.
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  180. Spector MP. The starvation-stress response (SSR) of Salmonella. Adv Microb Physiol. 1998; 40:233-79. PMID: 9889980.
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  181. Livingston BJ, Chmell MJ, Spector M, Poss R. Complications of total hip arthroplasty associated with the use of an acetabular component with a Hylamer liner. J Bone Joint Surg Am. 1997 Oct; 79(10):1529-38. PMID: 9378739.
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  182. Breinan HA, Minas T, Hsu HP, Nehrer S, Sledge CB, Spector M. Effect of cultured autologous chondrocytes on repair of chondral defects in a canine model. J Bone Joint Surg Am. 1997 Oct; 79(10):1439-51. PMID: 9378730.
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  183. Nehrer S, Breinan HA, Ramappa A, Young G, Shortkroff S, Louie LK, Sledge CB, Yannas IV, Spector M. Matrix collagen type and pore size influence behaviour of seeded canine chondrocytes. Biomaterials. 1997 Jun; 18(11):769-76. PMID: 9177854.
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  184. Patel AM, Spector M. Tribological evaluation of oxidized zirconium using an articular cartilage counterface: a novel material for potential use in hemiarthroplasty. Biomaterials. 1997 Mar; 18(5):441-7. PMID: 9061186.
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  185. Nehrer S, Breinan HA, Ramappa A, Shortkroff S, Young G, Minas T, Sledge CB, Yannas IV, Spector M. Canine chondrocytes seeded in type I and type II collagen implants investigated in vitro. J Biomed Mater Res. 1997; 38(2):95-104. PMID: 9178736.
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  186. Ries MD, Bellare A, Livingston BJ, Cohen RE, Spector M. Early delamination of a Hylamer-M tibial insert. J Arthroplasty. 1996 Dec; 11(8):974-6. PMID: 8986578.
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  187. Benz EB, Sherburne B, Hayek JE, Falchuk KH, Sledge CB, Spector M. Lymphadenopathy associated with total joint prostheses. A report of two cases and a review of the literature. J Bone Joint Surg Am. 1996 Apr; 78(4):588-93. PMID: 8609139.
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  188. Faryniarz DA, Chaponnier C, Gabbiani G, Yannas IV, Spector M. Myofibroblasts in the healing lapine medial collateral ligament: possible mechanisms of contraction. J Orthop Res. 1996 Mar; 14(2):228-37. PMID: 8648500.
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  189. Tucker BE, Cottell CM, Auyeung RC, Spector M, Nancollas GH. Pre-conditioning and dual constant composition dissolution kinetics of pulsed laser deposited hydroxyapatite thin films on silicon substrates. Biomaterials. 1996 Mar; 17(6):631-7. PMID: 8652782.
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  190. Shortkroff S, Barone L, Hsu HP, Wrenn C, Gagne T, Chi T, Breinan H, Minas T, Sledge CB, Tubo R, Spector M. Healing of chondral and osteochondral defects in a canine model: the role of cultured chondrocytes in regeneration of articular cartilage. Biomaterials. 1996 Jan; 17(2):147-54. PMID: 8624391.
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  191. Paschalis EP, Zhao Q, Tucker BE, Mukhopadhayay S, Bearcroft JA, Beals NB, Spector M, Nancollas GH. Degradation potential of plasma-sprayed hydroxyapatite-coated titanium implants. J Biomed Mater Res. 1995 Dec; 29(12):1499-505. PMID: 8600140.
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  192. Chen CS, Yannas IV, Spector M. Pore strain behaviour of collagen-glycosaminoglycan analogues of extracellular matrix. Biomaterials. 1995 Jul; 16(10):777-83. PMID: 7492708.
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  193. O'Neal CR, Gabriel WM, Turk AK, Libby SJ, Fang FC, Spector MP. RpoS is necessary for both the positive and negative regulation of starvation survival genes during phosphate, carbon, and nitrogen starvation in Salmonella typhimurium. J Bacteriol. 1994 Aug; 176(15):4610-6. PMID: 8045891; PMCID: PMC196281.
  194. Spector M. Anorganic bovine bone and ceramic analogs of bone mineral as implants to facilitate bone regeneration. Clin Plast Surg. 1994 Jul; 21(3):437-44. PMID: 7924142.
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  195. Robertson DD, Mintzer CM, Weissman BN, Ewald FC, LeBoff M, Spector M. Distal loss of femoral bone following total knee arthroplasty. Measurement with visual and computer-processing of roentgenograms and dual-energy x-ray absorptiometry. J Bone Joint Surg Am. 1994 Jan; 76(1):66-76. PMID: 8288667.
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  196. Cheal EJ, Spector M, Hayes WC. Role of loads and prosthesis material properties on the mechanics of the proximal femur after total hip arthroplasty. J Orthop Res. 1992 May; 10(3):405-22. PMID: 1569504.
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  197. Spector M. Biomaterial failure. Orthop Clin North Am. 1992 Apr; 23(2):211-7. PMID: 1570135.
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  198. Spector M, Shortkroff S, Hsu HP, Taylor-Zapatka S, Lane N, Sledge CB, Thornhill TS. Synovium-like tissue from loose joint replacement prosthesis: comparison of human material with a canine model. Semin Arthritis Rheum. 1992 Apr; 21(5):335-44. PMID: 1604328.
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  199. Spector M. Biomaterials: taming the beast. J Biomed Mater Res. 1992 Jan; 26(1):1-5. PMID: 1577830.
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  200. Galante JO, Lemons J, Spector M, Wilson PD, Wright TM. The biologic effects of implant materials. J Orthop Res. 1991 Sep; 9(5):760-75. PMID: 1870040.
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  201. Collier JP, Mayor MB, Surprenant VA, Dauphinais LA, Surprenant HP, Jensen RE, Chae JC, Spector M, Shortkroff S, Sledge CB, et al. Advances in implant-bone interface. Instr Course Lect. 1991; 40:89-113. PMID: 2045659.
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  202. Spector M, Shortkroff S, Hsu HP, Lane N, Sledge CB, Thornhill TS. Tissue changes around loose prostheses. A canine model to investigate the effects of an antiinflammatory agent. Clin Orthop Relat Res. 1990 Dec; (261):140-52. PMID: 2245540.
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  203. Mintzer CM, Robertson DD, Rackemann S, Ewald FC, Scott RD, Spector M. Bone loss in the distal anterior femur after total knee arthroplasty. Clin Orthop Relat Res. 1990 Nov; (260):135-43. PMID: 2225616.
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  204. Foster JW, Park YK, Penfound T, Fenger T, Spector MP. Regulation of NAD metabolism in Salmonella typhimurium: molecular sequence analysis of the bifunctional nadR regulator and the nadA-pnuC operon. J Bacteriol. 1990 Aug; 172(8):4187-96. PMID: 2198247; PMCID: PMC213241.
  205. Thornhill TS, Ozuna RM, Shortkroff S, Keller K, Sledge CB, Spector M. Biochemical and histological evaluation of the synovial-like tissue around failed (loose) total joint replacement prostheses in human subjects and a canine model. Biomaterials. 1990 Jul; 11:69-72. PMID: 2204438.
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  206. Hsu HP, Garg A, Walker PS, Spector M, Ewald FC. Effect of knee component alignment on tibial load distribution with clinical correlation. Clin Orthop Relat Res. 1989 Nov; (248):135-44. PMID: 2805471.
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  207. Poss R, Walker P, Spector M, Reilly DT, Robertson DD, Sledge CB. Strategies for improving fixation of femoral components in total hip arthroplasty. Clin Orthop Relat Res. 1988 Oct; (235):181-94. PMID: 3416525.
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  208. Spector M, Heyligers I, Roberson JR. Porous polymers for biological fixation. Clin Orthop Relat Res. 1988 Oct; (235):207-19. PMID: 2970907.
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  209. Roberson JR, Spector M, Baggett MA, Kita K. Porous-coated femoral components in a canine model for revision arthroplasty. J Bone Joint Surg Am. 1988 Sep; 70(8):1201-8. PMID: 3417705.
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  210. Rodgers AL, Spector M. Pancreatic calculi containing brushite: ultrastructure and pathogenesis. Calcif Tissue Int. 1986 Nov; 39(5):342-7. PMID: 3102025.
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  211. Tirgari S, Spector MP, Foster JW. Genetics of NAD metabolism in Salmonella typhimurium and cloning of the nadA and pnuC loci. J Bacteriol. 1986 Sep; 167(3):1086-8. PMID: 3017917; PMCID: PMC215988.
  212. Foster JW, Spector MP. Phosphate starvation regulon of Salmonella typhimurium. J Bacteriol. 1986 May; 166(2):666-9. PMID: 3009420; PMCID: PMC214656.
  213. Behling CA, Spector M. Quantitative characterization of cells at the interface of long-term implants of selected polymers. J Biomed Mater Res. 1986 May-Jun; 20(5):653-66. PMID: 3711138.
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  214. Turner RT, Bell NH, Duvall P, Bobyn JD, Spector M, Holton EM, Baylink DJ. Spaceflight results in formation of defective bone. Proc Soc Exp Biol Med. 1985 Dec; 180(3):544-9. PMID: 4080703.
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  215. Holley EA, Spector MP, Foster JW. Regulation of NAD biosynthesis in Salmonella typhimurium: expression of nad-lac gene fusions and identification of a nad regulatory locus. J Gen Microbiol. 1985 Oct; 131(10):2759-70. PMID: 3934331.
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  216. Khalil MA, Spector M. The conical cartilage of the cat's middle ear. J Laryngol Otol. 1985 Sep; 99(9):831-8. PMID: 4045303.
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  217. Hirshorn MS, Holley LK, Money DK, Spector M, Young FA, Hales JR. Histological evaluation of porous titanium cardiac pacemaker electrode tips. J Biomed Mater Res. 1984 Jan; 18(1):47-60. PMID: 6699032.
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  218. Vandersteenhoven JJ, Spector M. Histological investigation of bone induction by demineralized allogeneic bone matrix: a natural biomaterial for osseous reconstruction. J Biomed Mater Res. 1983 Nov; 17(6):1003-14. PMID: 6654924.
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  219. Teichgraeber JF, Spector M, Per-Lee JH, Jackson RT. Tissue response to Plasti-Pore and Proplast otologic implants in the middle ears of cats. Am J Otol. 1983 Oct; 5(2):127-36. PMID: 6359894.
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  220. Vandersteenhoven JJ, Spector M. Osteoinduction within porous polysulfone implants at extraosseous sites using demineralized allogeneic bone matrix. J Biomed Mater Res. 1983 Sep; 17(5):793-806. PMID: 6619176.
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  221. Spector M, Davis RJ, Lunceford EM, Harmon SL. Porous polysulfone coatings for fixation of femoral stems by bony ingrowth. Clin Orthop Relat Res. 1983 Jun; (176):34-41. PMID: 6851340.
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  222. Ramsay AW, Spector M, Rodgers AL, Miller RL, Knapp DR. Crystalluria following excretory urography. Br J Urol. 1982 Aug; 54(4):341-5. PMID: 7116098.
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  223. Hennis HL, Hennigar GR, Greene WB, Hilton CW, Spector M. Intratubular calcium phosphate deposition in acute analgesic nephropathy in rabbits. Am J Pathol. 1982 Mar; 106(3):356-63. PMID: 7065118; PMCID: PMC1916216.
  224. Rushton HG, Spector M. Effects of magnesium deficiency on intratubular calcium oxalate formation and crystalluria in hyperoxaluric rats. J Urol. 1982 Mar; 127(3):598-604. PMID: 7062446.
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  225. Spector M, Wigger WB, Buse MG. Radionuclide bone imaging of femoral prostheses with porous coatings. Clin Orthop Relat Res. 1981 Oct; (160):242-9. PMID: 6456858.
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  226. Hirshorn MS, Holley LK, Hales JR, Money DK, Young FA, Spector M, Wickham GG. Screening of solid and porous materials for pacemaker electrodes. Pacing Clin Electrophysiol. 1981 Jul; 4(4):380-90. PMID: 6167955.
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  227. Rushton HG, Spector M, Rodgers AL, Hughson M, Magura CE. Developmental aspects of calcium oxalate tubular deposits and calculi induced in rat kidneys. Invest Urol. 1981 Jul; 19(1):52-7. PMID: 7251328.
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  228. Rodgers A, Spector M. Human stones. Endeavour. 1981; 5(3):119-26. PMID: 6169518.
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  229. Brockbank KG, Ogawa M, Spector M. Hemopoiesis in demineralized bone allografts. Exp Hematol. 1980 Jul; 8(6):763-9. PMID: 7202580.
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  230. Magura CE, Spector M, Allen R, Turner WR. Brushite encrustation and lithiasis of the prostatic bed after transurethral resection of the prostate. J Urol. 1980 Feb; 123(2):294-7. PMID: 6153404.
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  231. Rushton HG, Spector M, Rodgers AL, Magura CE. Crystal deposition in the renal tubules of hyperoxaluric and hypomagnesemic rats. Scan Electron Microsc. 1980; (3):387-94, 398. PMID: 7414281.
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  232. Young FA, Spector M, Kresch CH. Porous titanium endosseous dental implants in Rhesus monkeys: microradiography and histological evaluation. J Biomed Mater Res. 1979 Nov; 13(6):843-56. PMID: 117007.
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  233. Spector M, Harmon SL, Kreutner A. Characteristics of tissue growth into Proplast and porous polyethylene implants in bone. J Biomed Mater Res. 1979 Sep; 13(5):677-92. PMID: 479215.
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  234. Young FA, Kresch CH, Spector M. Porous titanium tooth roots: clinical evaluation. J Prosthet Dent. 1979 May; 41(5):561-5. PMID: 108394.
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  235. Magura CE, Spector M. Scanning electron microscopy of human prostatic corpora amylacea and corpora calculi, and prostatic calculi. Scan Electron Microsc. 1979; (3):713-20. PMID: 524038.
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  236. Ballintyn NJ, Spector M. Porous polysulfone as an attachment vehicle for orthopedic and dental implants. Biomater Med Devices Artif Organs. 1979; 7(1):23-9. PMID: 110374.
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  237. Spector M, Michno MJ, Smarook WH, Kwiatkowski GT. A high-modulus polymer for porous orthopedic implants: biomechanical compatibility of porous implants. J Biomed Mater Res. 1978 Sep; 12(5):665-77. PMID: 701302.
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  238. Spector M, Garden NM, Rous SN. Ultrastructure and pathogenesis of human urinary calculi. Br J Urol. 1978 Feb; 50(1):12-5. PMID: 630196.
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  239. Balentine JD, Spector M. Calcification of axons in experimental spinal cord trauma. Ann Neurol. 1977 Dec; 2(6):520-3. PMID: 617593.
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  240. Spector M, Taylor SE. Fracture of human dentin: a high resolution scanning electron microscope study. J Dent Res. 1976 Nov-Dec; 55(6):1136. PMID: 1069766.
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  241. Spector M, Flemming WR, Kreutner A. Bone growth into porous high-density polyethylene. J Biomed Mater Res. 1976 Jul; 10(4):595-603. PMID: 947921.
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  242. Garvin AJ, Pratt-Thomas HR, Spector M, Spicer SS, Williamson HO. Gonadoblastoma: histologic, ultrastructural, and histochemical observations in five cases. Am J Obstet Gynecol. 1976 Jun 15; 125(4):459-71. PMID: 988750.
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  243. Spector M, Flemming WR, Sauer BW. Early tissue infiltrate in porous polyethylene implants into bone: a scanning electron microscope study. J Biomed Mater Res. 1975 Sep; 9(5):537-42. PMID: 1176523.
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  244. Spector M. High resolution electron microscope study of lattice images in biological apatites. J Microsc. 1975 Jan; 103(1):55-62. PMID: 1173603.
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  245. Spector M, Burns LC, Kimzey SL. Ion beam etching of red blood cells and latex spheres. Nature. 1974 Jan 04; 247(5435):61-2. PMID: 4587641.
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  246. Spector M, Krokosky EM, Sax M, Pletcher J. Atherosclerotic plaque: x-ray diffraction investigation. Science. 1969 Aug 15; 165(3894):711. PMID: 5793976.
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