Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

David Lewis Perez, M.D.

Title
Institution
Department
Address

Biography
2007
Alpha Omega Alpha
2012
Outstanding Psychiatry Resident Teacher
2012
Young Investigator Award, American Neuropsychiatric Association (ANPA)
2013
Joseph J. Schildraut Research Award
2014
Career Development Award, American Neuropsychiatric Association (ANPA)

Overview
David L. Perez M.D., M.M.S.c. is a faculty member in the Departments of Neurology and Psychiatry at the Massachusetts General Hospital. Dr. Perez is the director of the MGH Functional Neurology Research Group, which is dedicated to the comprehensive clinical and neurobiological investigation of motor Functional Neurological Disorders. The laboratory uses neuropsychiatric clinical research assessments and advanced structural and functional magnetic resonance imaging (MRI) techniques to investigate clinical and biological markers of symptom severity, disease-risk, subtype and prognosis across individuals with Psychogenic Nonepileptic Seizures, Functional Movement Disorders and Functional Limb Weakness.

Dr. Perez is also the founding director of the Functional Neurological Disorders Clinic based within the Cognitive Behavioral Neurology Unit and affiliated with the Neuropsychiatry Unit at the Massachusetts General Hospital. In the MGH Functional Neurological Disorders Clinic, Dr. Perez provides specialized, integrated neurologic and psychiatric consultations for patients experiencing motor Functional Neurological Disorders, including individuals with Psychogenic Nonepileptic Seizures, Functional Movement Disorders, and Functional Limb Weakness. The clinic closely collaborates with physiotherapists, occupational therapists, speech and language pathologists, neuropsychologists, and psychotherapists.

Dr. Perez is affiliated with the MGH/HST Athinoula A. Martinos Center for Biomedical Imaging, and collaborates with other investigators within the Harvard Medical School Hospital system.

Dr. Perez is a dual trained neurologist-psychiatrist, and is a member of the Cognitive Behavioral Neurology and Neuropsychiatry Units at Massachusetts General Hospital.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K23MH111983 (PEREZ, DAVID LEWIS) Sep 14, 2017 - Aug 31, 2022
    NIH/NIMH
    Neuroimaging Biomarkers of Symptom Severity, Adverse Life Events and Prognosis in Motor Functional Neurological Disorders
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Pick S, Goldstein LH, Perez DL, Nicholson TR. Emotional processing in functional neurological disorder: a review, biopsychosocial model and research agenda. J Neurol Neurosurg Psychiatry. 2018 Nov 19. PMID: 30455406.
    View in: PubMed
  2. Williams B, Ospina JP, Jalilianhasanpour R, Fricchione GL, Perez DL. Fearful Attachment Linked to Childhood Abuse, Alexithymia, and Depression in Motor Functional Neurological Disorders. J Neuropsychiatry Clin Neurosci. 2018 Oct 31; appineuropsych18040095. PMID: 30376786.
    View in: PubMed
  3. Xin Q, Ortiz-Terán L, Diez I, Perez DL, Ginsburg J, El Fakhri G, Sepulcre J. Sequence Alterations of Cortical Genes Linked to Individual Connectivity of the Human Brain. Cereb Cortex. 2018 Oct 11. PMID: 30307489.
    View in: PubMed
  4. Jalilianhasanpour R, Ospina JP, Williams B, Mello J, MacLean J, Ranford J, Fricchione GL, LaFrance WC, Perez DL. Secure Attachment and Depression Predict 6-Month Outcome in Motor Functional Neurological Disorders: A Prospective Pilot Study. Psychosomatics. 2018 Aug 29. PMID: 30342702.
    View in: PubMed
  5. Perez DL, Keshavan MS, Scharf JM, Boes AD, Price BH. Bridging the Great Divide: What Can Neurology Learn From Psychiatry? J Neuropsychiatry Clin Neurosci. 2018 Jun 25; appineuropsych17100200. PMID: 29939105.
    View in: PubMed
  6. Ranford J, Perez DL, MacLean J. Additional occupational therapy considerations for functional neurological disorders: a potential role for sensory processing. CNS Spectr. 2018 Jun; 23(3):194-195. PMID: 29781409.
    View in: PubMed
  7. Adams C, Anderson J, Madva EN, LaFrance WC, Perez DL. You've made the diagnosis of functional neurological disorder: now what? Pract Neurol. 2018 Aug; 18(4):323-330. PMID: 29764988.
    View in: PubMed
  8. Williams B, Jalilianhasanpour R, Matin N, Fricchione GL, Sepulcre J, Keshavan MS, LaFrance WC, Dickerson BC, Perez DL. Individual differences in corticolimbic structural profiles linked to insecure attachment and coping styles in motor functional neurological disorders. J Psychiatr Res. 2018 Jul; 102:230-237. PMID: 29702433.
    View in: PubMed
  9. Peterson KT, Kosior R, Meek BP, Ng M, Perez DL, Modirrousta M. Right Temporoparietal Junction Transcranial Magnetic Stimulation in the Treatment of Psychogenic Nonepileptic Seizures: A Case Series. Psychosomatics. 2018 Nov; 59(6):601-606. PMID: 29628295.
    View in: PubMed
  10. Jalilianhasanpour R, Williams B, Gilman I, Burke MJ, Glass S, Fricchione GL, Keshavan MS, LaFrance WC, Perez DL. Resilience linked to personality dimensions, alexithymia and affective symptoms in motor functional neurological disorders. J Psychosom Res. 2018 Apr; 107:55-61. PMID: 29502765.
    View in: PubMed
  11. Perez DL, Williams B, Matin N, Mello J, Dickerson BC, LaFrance WC, Keshavan MS. Anterior hippocampal grey matter predicts mental health outcome in functional neurological disorders: an exploratory pilot study. J Neurol Neurosurg Psychiatry. 2018 Nov; 89(11):1221-1224. PMID: 29326291.
    View in: PubMed
  12. McKee K, Glass S, Adams C, Stephen CD, King F, Parlman K, Perez DL, Kontos N. The Inpatient Assessment and Management of Motor Functional Neurological Disorders: An Interdisciplinary Perspective. Psychosomatics. 2018 Jul - Aug; 59(4):358-368. PMID: 29628294.
    View in: PubMed
  13. Glass SP, Matin N, Williams B, Mello J, Stephen CD, Young SS, Callahan J, LaFrance WC, Perez DL. Neuropsychiatric Factors Linked to Adherence and Short-Term Outcome in a U.S. Functional Neurological Disorders Clinic: A Retrospective Cohort Study. J Neuropsychiatry Clin Neurosci. 2018; 30(2):152-159. PMID: 29132273.
    View in: PubMed
  14. Perez DL, Matin N, Williams B, Tanev K, Makris N, LaFrance WC, Dickerson BC. Cortical thickness alterations linked to somatoform and psychological dissociation in functional neurological disorders. Hum Brain Mapp. 2018 01; 39(1):428-439. PMID: 29080235.
    View in: PubMed
  15. Stephen CD, Sharma N, Callahan J, Carson AJ, Perez DL. A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. Harv Rev Psychiatry. 2017 Sep/Oct; 25(5):241-251. PMID: 28650853.
    View in: PubMed
  16. Perez DL, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2017 Dec; 88(12):1052-1059. PMID: 28844071.
    View in: PubMed
  17. Perez DL, Voon V. Psychogenic Nonepileptic Seizures: Toward the Integration of Care. The Neurobiology of PNES and Other Functional Neurological Symptoms. 2017.
  18. Chandra P, Kozlowska K, Cruz C, Baslet GC, Perez DL, Garralda ME. Hyperventilation-Induced Non-epileptic Seizures in an Adolescent Boy with Pediatric Medical Traumatic Stress. Harv Rev Psychiatry. 2017 Jul/Aug; 25(4):180-190. PMID: 28471819.
    View in: PubMed
  19. Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc Natl Acad Sci U S A. 2017 06 27; 114(26):6830-6835. PMID: 28607055.
    View in: PubMed
  20. Matin N, Young SS, Williams B, LaFrance WC, King JN, Caplan D, Chemali Z, Weilburg JB, Dickerson BC, Perez DL. Neuropsychiatric Associations With Gender, Illness Duration, Work Disability, and Motor Subtype in a U.S. Functional Neurological Disorders Clinic Population. J Neuropsychiatry Clin Neurosci. 2017; 29(4):375-382. PMID: 28449634.
    View in: PubMed
  21. Perez DL, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 06; 88(6):491-497. PMID: 28416565.
    View in: PubMed
  22. Perez DL, Young SS, King JN, Guarino AJ, Dworetzky BA, Flaherty A, Chemali Z, Caplan D, Dickerson BC. Preliminary Predictors of Initial Attendance, Symptom Burden, and Motor Subtype in a US Functional Neurological Disorders Clinic Population. Cogn Behav Neurol. 2016 Dec; 29(4):197-205. PMID: 27984257.
    View in: PubMed
  23. Perez D, Eldaief, M, Epstein J, Silbersweig D, Stern E. Depression in Medical Illness. The Neurobiology of Depression: An Integrated Systems-Level, Cellular–Molecular and Genetic Overview. 2016.
  24. Ortiz-Terán L, Ortiz T, Perez DL, Aragón JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci. 2016; 10:61. PMID: 27458350; PMCID: PMC4937754.
  25. Perez DL, Torous J, Stern AP, Padmanabhan JL, Keshavan MS. Response to "Tandon et al. Psychiatry is a clinical neuroscience, but how do we move the field". Asian J Psychiatr. 2016 Aug; 22:15-6. PMID: 27520888.
    View in: PubMed
  26. Perez DL, LaFrance WC. Nonepileptic seizures: an updated review. CNS Spectr. 2016 Jun; 21(3):239-46. PMID: 26996600.
    View in: PubMed
  27. Fischer DB, Perez DL, Prasad S, Rigolo L, O'Donnell L, Acar D, Meadows ME, Baslet G, Boes AD, Golby AJ, Dworetzky BA. Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration. Soc Cogn Affect Neurosci. 2016 06; 11(6):945-51. PMID: 26940563.
    View in: PubMed
  28. Perez DL, Murray ED, Price BH. Bradley's Neurology in Clinical Practice. Depression and Psychosis in Neurological Practice. 2016; 92-114.
  29. Perez DL, Vago DR, Pan H, Root J, Tuescher O, Fuchs BH, Leung L, Epstein J, Cain NM, Clarkin JF, Lenzenweger MF, Kernberg OF, Levy KN, Silbersweig DA, Stern E. Frontolimbic neural circuit changes in emotional processing and inhibitory control associated with clinical improvement following transference-focused psychotherapy in borderline personality disorder. Psychiatry Clin Neurosci. 2016 Jan; 70(1):51-61. PMID: 26289141; PMCID: PMC4718821 [Available on 01/01/17].
  30. Perez DL, Pan H, Weisholtz DS, Root JC, Tuescher O, Fischer DB, Butler T, Vago DR, Isenberg N, Epstein J, Landa Y, Smith TE, Savitz AJ, Silbersweig DA, Stern E. Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study. Psychiatry Res. 2015 Sep 30; 233(3):352-66. PMID: 26208746; PMCID: PMC5003172 [Available on 09/30/16].
  31. Torous J, Stern AP, Padmanabhan JL, Keshavan MS, Perez DL. A proposed solution to integrating cognitive-affective neuroscience and neuropsychiatry in psychiatry residency training: The time is now. Asian J Psychiatr. 2015 Oct; 17:116-21. PMID: 26054985.
    View in: PubMed
  32. Dworetzky BA, Weisholtz DS, Perez DL, Baslet G. A clinically oriented perspective on psychogenic nonepileptic seizure-related emergencies. Clin EEG Neurosci. 2015 Jan; 46(1):26-33. PMID: 25780265.
    View in: PubMed
  33. Reinsberger C, Sarkis R, Papadelis C, Doshi C, Perez DL, Baslet G, Loddenkemper T, Dworetzky BA. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. PMID: 25780264.
    View in: PubMed
  34. Baslet G, Dworetzky BA, Perez DL. Psychogenic nonepileptic seizures: a new direction. Clin EEG Neurosci. 2015 Jan; 46(1):3. PMID: 25780263.
    View in: PubMed
  35. Perez DL, Ortiz Teran L, Silbersweig DA. In: Psychiatric Care of the Medical Patient. Edited by Fogel BS, Greenberg DB. Neuroimaging in Psychiatry: The Clinical Radiographic Correlate. 2015; 137-154.
  36. Baslet G, Dworetzky B, Perez DL, Oser M. Treatment of psychogenic nonepileptic seizures: updated review and findings from a mindfulness-based intervention case series. Clin EEG Neurosci. 2015 Jan; 46(1):54-64. PMID: 25465435; PMCID: PMC4552047.
  37. Perez DL, Dworetzky BA, Dickerson BC, Leung L, Cohn R, Baslet G, Silbersweig DA. An integrative neurocircuit perspective on psychogenic nonepileptic seizures and functional movement disorders: neural functional unawareness. Clin EEG Neurosci. 2015 Jan; 46(1):4-15. PMID: 25432161; PMCID: PMC4363170.
  38. Perez DL, Barsky AJ, Vago DR, Baslet G, Silbersweig DA. A neural circuit framework for somatosensory amplification in somatoform disorders. J Neuropsychiatry Clin Neurosci. 2015; 27(1):e40-50. PMID: 25716493.
    View in: PubMed
  39. Perez DL, Fuchs BH, Epstein J. A case of cotard syndrome in a woman with a right subdural hemorrhage. J Neuropsychiatry Clin Neurosci. 2014; 26(1):E29-30. PMID: 24515701.
    View in: PubMed
  40. Cho-Park YA, Perez DL, Milligan TA, Cho PF. Radiographic evolution of a rapidly reversible leukoencephalopathy due to metronidazole. Neurol Clin Pract. 2013 Jun; 3(3):272-274. PMID: 29473640.
    View in: PubMed
  41. Biswas J, Chu JA, Perez DL, Gutheil TG. From the neuropsychiatric to the analytic: three perspectives on dissociative identity disorder. Harv Rev Psychiatry. 2013 Jan-Feb; 21(1):41-51. PMID: 23656761.
    View in: PubMed
  42. Perez DL, Dickerson BC, McGinnis SM, Sapolsky D, Johnson K, Searl M, Daffner KR. You don't say: dynamic aphasia, another variant of primary progressive aphasia? J Alzheimers Dis. 2013; 34(1):139-44. PMID: 23168447; PMCID: PMC3621037.
  43. Perez DL, Hunt P, Trieu M. A case of dual dissociative and re-experiencing/hyperarousal subtypes in childhood PTSD: a neuropsychiatric formulation. J Neuropsychiatry Clin Neurosci. 2013; 25(1):E24-5. PMID: 23487216.
    View in: PubMed
  44. Perez DL, Barsky AJ, Daffner K, Silbersweig DA. Motor and somatosensory conversion disorder: a functional unawareness syndrome? J Neuropsychiatry Clin Neurosci. 2012; 24(2):141-51. PMID: 22772662.
    View in: PubMed
  45. Reinsberger C, Perez DL, Murphy MM, Dworetzky BA. Pre- and postictal, not ictal, heart rate distinguishes complex partial and psychogenic nonepileptic seizures. Epilepsy Behav. 2012 Jan; 23(1):68-70. PMID: 22100065.
    View in: PubMed
  46. Perez DL, Larvie M, Acar D, Daffner K. Teaching NeuroImages: apathetic variant of frontotemporal dementia. Neurology. 2011 Nov 15; 77(20):e117. PMID: 22084280.
    View in: PubMed
  47. Perez DL, Catenaccio E, Epstein J. Journal of Neurology and Neurophysiology. Confusion, Hyperactive Delirium, and Secondary Mania in Right Hemispheric Strokes: A Focused Review of Neuroanatomical Correlates. 2011.
  48. Epstein J, Perez DL, Ervin K, Pan H, Kocsis JH, Butler T, Stern E, Silbersweig DA. Failure to segregate emotional processing from cognitive and sensorimotor processing in major depression. Psychiatry Res. 2011 Sep 30; 193(3):144-50. PMID: 21764265.
    View in: PubMed
  49. Benbadis SR. Teaching Video NeuroImages: complex partial seizure evolving into a psychogenic nonepileptic seizure. Neurology. 2011 May 10; 76(19):1681; author reply 1681. PMID: 21555740.
    View in: PubMed
  50. Espinosa PS, Perez DL, Abner E, Ryan M. Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. Clin Neurol Neurosurg. 2011 Sep; 113(7):548-51. PMID: 21507568.
    View in: PubMed
  51. Perez DL, Haldar A, Rotenberg A, Kothare SV. Teaching Video NeuroImages: complex partial seizure evolving into a psychogenic nonepileptic seizure. Neurology. 2010 Dec 14; 75(24):e98. PMID: 21172839.
    View in: PubMed
  52. Perez DL, Diamond EL, Castro CM, Diaz A, Buonanno F, Nogueira RG, Sheth K. Factor XIII deficiency related recurrent spontaneous intracerebral hemorrhage: a case and literature review. Clin Neurol Neurosurg. 2011 Feb; 113(2):142-5. PMID: 20950938.
    View in: PubMed
  53. Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Ann Med. 2010 Mar; 42(2):115-22. PMID: 20121549.
    View in: PubMed
  54. Rogan MT, Leon KS, Perez DL, Kandel ER. Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron. 2005 Apr 21; 46(2):309-20. PMID: 15848808.
    View in: PubMed
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Perez's Networks
Click the
Explore
buttons for more information and interactive visualizations!
Concepts (174)
Explore
_
Co-Authors (50)
Explore
_
Similar People (60)
Explore
_
Same Department 
Explore
_
Physical Neighbors
_
Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.