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Last Name

profileDavid Lewis Perez, M.D.

TitleAssistant Professor of Neurology
InstitutionMassachusetts General Hospital
AddressMassachusetts General Hospital
Neurology WACC
55 Fruit St
Boston MA 02114
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Collapse awards and honors
2007Alpha Omega Alpha
2012Outstanding Psychiatry Resident Teacher
2012Young Investigator Award, American Neuropsychiatric Association (ANPA)
2013Joseph J. Schildraut Research Award
2014Career Development Award, American Neuropsychiatric Association (ANPA)

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David L. Perez M.D., M.M.S.c. is a faculty member in the Departments of Neurology and Psychiatry at the Massachusetts General Hospital. Dr. Perez is the director of the MGH Functional Neurology Research Group, which is dedicated to the comprehensive clinical and neurobiological investigation of motor Functional Neurological Disorders. The laboratory uses neuropsychiatric clinical research assessments and advanced structural and functional magnetic resonance imaging (MRI) techniques to investigate clinical and biological markers of symptom severity, disease-risk, subtype and prognosis across individuals with Psychogenic Nonepileptic Seizures, Functional Movement Disorders and Functional Limb Weakness.

Dr. Perez is also the director of the Functional Neurological Disorders Clinic based within the Cognitive Behavioral Neurology Unit and closely affiliated with the Neuropsychiatry Unit at the Massachusetts General Hospital. In the MGH Functional Neurological Disorders Clinic, Dr. Perez provides specialized, integrated neurologic and psychiatric consultations for patients experiencing motor Functional Neurological Disorders, including individuals with Psychogenic Nonepileptic Seizures, Functional Movement Disorders, and Functional Limb Weakness.

Dr. Perez works closely with colleagues at the MGH/HST Athinoula A. Martinos Center for Biomedical Imaging and within the Harvard Medical School Hospital system.

Dr. Perez is a dual trained neurologist-psychiatrist, and is a member of the Cognitive Behavioral Neurology, Frontotemporal/Memory Disorders and Neuropsychiatry Units at Massachusetts General Hospital.

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The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
K23MH111983     (PEREZ, DAVID LEWIS)Sep 14, 2017 - Aug 31, 2022
Neuroimaging Biomarkers of Symptom Severity, Adverse Life Events and Prognosis in Motor Functional Neurological Disorders
Role: Principal Investigator

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Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Jalilianhasanpour R, Williams B, Gilman I, Burke MJ, Glass S, Fricchione GL, Keshavan MS, LaFrance WC, Perez DL. Resilience linked to personality dimensions, alexithymia and affective symptoms in motor functional neurological disorders. J Psychosom Res. 2018 Apr; 107:55-61. PMID: 29502765.
    View in: PubMed
  2. Perez DL, Williams B, Matin N, Mello J, Dickerson BC, LaFrance WC, Keshavan MS. Anterior hippocampal grey matter predicts mental health outcome in functional neurological disorders: an exploratory pilot study. J Neurol Neurosurg Psychiatry. 2018 Jan 11. PMID: 29326291.
    View in: PubMed
  3. Glass SP, Matin N, Williams B, Mello J, Stephen CD, Young SS, Callahan J, LaFrance WC, Perez DL. Neuropsychiatric Factors Linked to Adherence and Short-Term Outcome in a U.S. Functional Neurological Disorders Clinic: A Retrospective Cohort Study. J Neuropsychiatry Clin Neurosci. 2017 Nov 14; appineuropsych17060117. PMID: 29132273.
    View in: PubMed
  4. Perez DL, Matin N, Williams B, Tanev K, Makris N, LaFrance WC, Dickerson BC. Cortical thickness alterations linked to somatoform and psychological dissociation in functional neurological disorders. Hum Brain Mapp. 2018 01; 39(1):428-439. PMID: 29080235.
    View in: PubMed
  5. Stephen CD, Sharma N, Callahan J, Carson AJ, Perez DL. A Case of Functional Dystonia with Associated Functional Neurological Symptoms: Diagnostic and Therapeutic Challenges. Harv Rev Psychiatry. 2017 Sep/Oct; 25(5):241-251. PMID: 28650853.
    View in: PubMed
  6. Perez DL, Williams B, Matin N, LaFrance WC, Costumero-Ramos V, Fricchione GL, Sepulcre J, Keshavan MS, Dickerson BC. Corticolimbic structural alterations linked to health status and trait anxiety in functional neurological disorder. J Neurol Neurosurg Psychiatry. 2017 Dec; 88(12):1052-1059. PMID: 28844071.
    View in: PubMed
  7. Chandra P, Kozlowska K, Cruz C, Baslet GC, Perez DL, Garralda ME. Hyperventilation-Induced Non-epileptic Seizures in an Adolescent Boy with Pediatric Medical Traumatic Stress. Harv Rev Psychiatry. 2017 Jul/Aug; 25(4):180-190. PMID: 28471819.
    View in: PubMed
  8. Ortiz-Terán L, Diez I, Ortiz T, Perez DL, Aragón JI, Costumero V, Pascual-Leone A, El Fakhri G, Sepulcre J. Brain circuit-gene expression relationships and neuroplasticity of multisensory cortices in blind children. Proc Natl Acad Sci U S A. 2017 Jun 27; 114(26):6830-6835. PMID: 28607055.
    View in: PubMed
  9. Matin N, Young SS, Williams B, LaFrance WC, King JN, Caplan D, Chemali Z, Weilburg JB, Dickerson BC, Perez DL. Neuropsychiatric Associations With Gender, Illness Duration, Work Disability, and Motor Subtype in a U.S. Functional Neurological Disorders Clinic Population. J Neuropsychiatry Clin Neurosci. 2017; 29(4):375-382. PMID: 28449634.
    View in: PubMed
  10. Perez DL, Matin N, Barsky A, Costumero-Ramos V, Makaretz SJ, Young SS, Sepulcre J, LaFrance WC, Keshavan MS, Dickerson BC. Cingulo-insular structural alterations associated with psychogenic symptoms, childhood abuse and PTSD in functional neurological disorders. J Neurol Neurosurg Psychiatry. 2017 Jun; 88(6):491-497. PMID: 28416565.
    View in: PubMed
  11. Perez DL, Young SS, King JN, Guarino AJ, Dworetzky BA, Flaherty A, Chemali Z, Caplan D, Dickerson BC. Preliminary Predictors of Initial Attendance, Symptom Burden, and Motor Subtype in a US Functional Neurological Disorders Clinic Population. Cogn Behav Neurol. 2016 Dec; 29(4):197-205. PMID: 27984257.
    View in: PubMed
  12. Ortiz-Terán L, Ortiz T, Perez DL, Aragón JI, Diez I, Pascual-Leone A, Sepulcre J. Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices. Front Syst Neurosci. 2016; 10:61. PMID: 27458350; PMCID: PMC4937754.
  13. Perez DL, Torous J, Stern AP, Padmanabhan JL, Keshavan MS. Response to "Tandon et al. Psychiatry is a clinical neuroscience, but how do we move the field". Asian J Psychiatr. 2016 Aug; 22:15-6. PMID: 27520888.
    View in: PubMed
  14. Perez DL, LaFrance WC. Nonepileptic seizures: an updated review. CNS Spectr. 2016 Jun; 21(3):239-46. PMID: 26996600.
    View in: PubMed
  15. Fischer DB, Perez DL, Prasad S, Rigolo L, O'Donnell L, Acar D, Meadows ME, Baslet G, Boes AD, Golby AJ, Dworetzky BA. Right inferior longitudinal fasciculus lesions disrupt visual-emotional integration. Soc Cogn Affect Neurosci. 2016 06; 11(6):945-51. PMID: 26940563.
    View in: PubMed
  16. Perez DL, Murray ED, Price BH. Bradley's Neurology in Clinical Practice. Depression and Psychosis in Neurological Practice. 2016; 92-114.
  17. Perez DL, Vago DR, Pan H, Root J, Tuescher O, Fuchs BH, Leung L, Epstein J, Cain NM, Clarkin JF, Lenzenweger MF, Kernberg OF, Levy KN, Silbersweig DA, Stern E. Frontolimbic neural circuit changes in emotional processing and inhibitory control associated with clinical improvement following transference-focused psychotherapy in borderline personality disorder. Psychiatry Clin Neurosci. 2016 Jan; 70(1):51-61. PMID: 26289141; PMCID: PMC4718821 [Available on 01/01/17].
  18. Perez DL, Pan H, Weisholtz DS, Root JC, Tuescher O, Fischer DB, Butler T, Vago DR, Isenberg N, Epstein J, Landa Y, Smith TE, Savitz AJ, Silbersweig DA, Stern E. Altered threat and safety neural processing linked to persecutory delusions in schizophrenia: a two-task fMRI study. Psychiatry Res. 2015 Sep 30; 233(3):352-66. PMID: 26208746; PMCID: PMC5003172 [Available on 09/30/16].
  19. Torous J, Stern AP, Padmanabhan JL, Keshavan MS, Perez DL. A proposed solution to integrating cognitive-affective neuroscience and neuropsychiatry in psychiatry residency training: The time is now. Asian J Psychiatr. 2015 Oct; 17:116-21. PMID: 26054985.
    View in: PubMed
  20. Dworetzky BA, Weisholtz DS, Perez DL, Baslet G. A clinically oriented perspective on psychogenic nonepileptic seizure-related emergencies. Clin EEG Neurosci. 2015 Jan; 46(1):26-33. PMID: 25780265.
    View in: PubMed
  21. Reinsberger C, Sarkis R, Papadelis C, Doshi C, Perez DL, Baslet G, Loddenkemper T, Dworetzky BA. Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker? Clin EEG Neurosci. 2015 Jan; 46(1):16-25. PMID: 25780264.
    View in: PubMed
  22. Baslet G, Dworetzky BA, Perez DL. Psychogenic nonepileptic seizures: a new direction. Clin EEG Neurosci. 2015 Jan; 46(1):3. PMID: 25780263.
    View in: PubMed
  23. Perez DL, Ortiz Teran L, Silbersweig DA. In: Psychiatric Care of the Medical Patient. Edited by Fogel BS, Greenberg DB. Neuroimaging in Psychiatry: The Clinical Radiographic Correlate. 2015; 137-154.
  24. Baslet G, Dworetzky B, Perez DL, Oser M. Treatment of psychogenic nonepileptic seizures: updated review and findings from a mindfulness-based intervention case series. Clin EEG Neurosci. 2015 Jan; 46(1):54-64. PMID: 25465435; PMCID: PMC4552047.
  25. Perez DL, Dworetzky BA, Dickerson BC, Leung L, Cohn R, Baslet G, Silbersweig DA. An integrative neurocircuit perspective on psychogenic nonepileptic seizures and functional movement disorders: neural functional unawareness. Clin EEG Neurosci. 2015 Jan; 46(1):4-15. PMID: 25432161; PMCID: PMC4363170.
  26. Perez DL, Barsky AJ, Vago DR, Baslet G, Silbersweig DA. A neural circuit framework for somatosensory amplification in somatoform disorders. J Neuropsychiatry Clin Neurosci. 2015; 27(1):e40-50. PMID: 25716493.
    View in: PubMed
  27. Perez DL, Fuchs BH, Epstein J. A case of cotard syndrome in a woman with a right subdural hemorrhage. J Neuropsychiatry Clin Neurosci. 2014; 26(1):E29-30. PMID: 24515701.
    View in: PubMed
  28. Cho-Park YA, Perez DL, Milligan TA, Cho PF. Radiographic evolution of a rapidly reversible leukoencephalopathy due to metronidazole. Neurol Clin Pract. 2013 Jun; 3(3):272-274. PMID: 29473640.
    View in: PubMed
  29. Biswas J, Chu JA, Perez DL, Gutheil TG. From the neuropsychiatric to the analytic: three perspectives on dissociative identity disorder. Harv Rev Psychiatry. 2013 Jan-Feb; 21(1):41-51. PMID: 23656761.
    View in: PubMed
  30. Perez DL, Dickerson BC, McGinnis SM, Sapolsky D, Johnson K, Searl M, Daffner KR. You don't say: dynamic aphasia, another variant of primary progressive aphasia? J Alzheimers Dis. 2013; 34(1):139-44. PMID: 23168447; PMCID: PMC3621037.
  31. Perez DL, Hunt P, Trieu M. A case of dual dissociative and re-experiencing/hyperarousal subtypes in childhood PTSD: a neuropsychiatric formulation. J Neuropsychiatry Clin Neurosci. 2013; 25(1):E24-5. PMID: 23487216.
    View in: PubMed
  32. Perez DL, Barsky AJ, Daffner K, Silbersweig DA. Motor and somatosensory conversion disorder: a functional unawareness syndrome? J Neuropsychiatry Clin Neurosci. 2012; 24(2):141-51. PMID: 22772662.
    View in: PubMed
  33. Reinsberger C, Perez DL, Murphy MM, Dworetzky BA. Pre- and postictal, not ictal, heart rate distinguishes complex partial and psychogenic nonepileptic seizures. Epilepsy Behav. 2012 Jan; 23(1):68-70. PMID: 22100065.
    View in: PubMed
  34. Perez DL, Larvie M, Acar D, Daffner K. Teaching NeuroImages: apathetic variant of frontotemporal dementia. Neurology. 2011 Nov 15; 77(20):e117. PMID: 22084280.
    View in: PubMed
  35. Perez DL, Catenaccio E, Epstein J. Journal of Neurology and Neurophysiology. Confusion, Hyperactive Delirium, and Secondary Mania in Right Hemispheric Strokes: A Focused Review of Neuroanatomical Correlates. 2011.
  36. Epstein J, Perez DL, Ervin K, Pan H, Kocsis JH, Butler T, Stern E, Silbersweig DA. Failure to segregate emotional processing from cognitive and sensorimotor processing in major depression. Psychiatry Res. 2011 Sep 30; 193(3):144-50. PMID: 21764265.
    View in: PubMed
  37. Benbadis SR. Teaching Video NeuroImages: complex partial seizure evolving into a psychogenic nonepileptic seizure. Neurology. 2011 May 10; 76(19):1681; author reply 1681. PMID: 21555740.
    View in: PubMed
  38. Espinosa PS, Perez DL, Abner E, Ryan M. Association of antiepileptic drugs, vitamin D, and calcium supplementation with bone fracture occurrence in epilepsy patients. Clin Neurol Neurosurg. 2011 Sep; 113(7):548-51. PMID: 21507568.
    View in: PubMed
  39. Perez DL, Haldar A, Rotenberg A, Kothare SV. Teaching Video NeuroImages: complex partial seizure evolving into a psychogenic nonepileptic seizure. Neurology. 2010 Dec 14; 75(24):e98. PMID: 21172839.
    View in: PubMed
  40. Perez DL, Diamond EL, Castro CM, Diaz A, Buonanno F, Nogueira RG, Sheth K. Factor XIII deficiency related recurrent spontaneous intracerebral hemorrhage: a case and literature review. Clin Neurol Neurosurg. 2011 Feb; 113(2):142-5. PMID: 20950938.
    View in: PubMed
  41. Pollak DD, Rogan MT, Egner T, Perez DL, Yanagihara TK, Hirsch J. A translational bridge between mouse and human models of learned safety. Ann Med. 2010 Mar; 42(2):115-22. PMID: 20121549.
    View in: PubMed
  42. Rogan MT, Leon KS, Perez DL, Kandel ER. Distinct neural signatures for safety and danger in the amygdala and striatum of the mouse. Neuron. 2005 Apr 21; 46(2):309-20. PMID: 15848808.
    View in: PubMed
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