Harvard Catalyst Profiles

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Raymond J. Kelleher III, M.D.,PH.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. K24NS093185 (KELLEHER, RAYMOND J) Apr 1, 2016 - Mar 31, 2021
    NIH/NINDS
    Research Mentoring in Neurology and Translational Research on Alzheimers Disease
    Role: Principal Investigator
  2. R01NS075346 (KELLEHER, RAYMOND J) Jul 1, 2011 - Jun 30, 2021
    NIH/NINDS
    Mechanisms of brain phenotypes caused by FAD-linked Presenilin-1 Mutations
    Role: Principal Investigator
  3. K02MH087796 (KELLEHER, RAYMOND J) Dec 14, 2009 - Nov 30, 2014
    NIH/NIMH
    MicroRNAs in Synaptic Plasticity and Behaviors Relevant to Autism
    Role: Principal Investigator
  4. R01MH080430 (KELLEHER, RAYMOND J) Apr 1, 2007 - Mar 31, 2013
    NIH/NIMH
    MicroRNAs in Synaptic Plasticity and Cognitive Function
    Role: Principal Investigator
  5. K02NS048274 (KELLEHER, RAYMOND J) Dec 15, 2004 - Aug 31, 2010
    NIH/NINDS
    Translational Control in Long-Term Synaptic Plasticity
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Carrette LLG, Blum R, Ma W, Kelleher RJ, Lee JT. Tsix-Mecp2 female mouse model for Rett syndrome reveals that low-level MECP2 expression extends life and improves neuromotor function. Proc Natl Acad Sci U S A. 2018 08 07; 115(32):8185-8190. PMID: 30038001.
    Citations:    Fields:    Translation:HumansAnimals
  2. Carrette LLG, Wang CY, Wei C, Press W, Ma W, Kelleher RJ, Lee JT. A mixed modality approach towards Xi reactivation for Rett syndrome and other X-linked disorders. Proc Natl Acad Sci U S A. 2018 01 23; 115(4):E668-E675. PMID: 29282321.
    Citations: 4     Fields:    Translation:AnimalsCells
  3. Kelleher RJ, Shen J. Presenilin-1 mutations and Alzheimer's disease. Proc Natl Acad Sci U S A. 2017 01 24; 114(4):629-631. PMID: 28082723.
    Citations: 5     Fields:    Translation:Humans
  4. Xia D, Kelleher RJ, Shen J. Loss of Aß43 Production Caused by Presenilin-1 Mutations in the Knockin Mouse Brain. Neuron. 2016 04 20; 90(2):417-22. PMID: 27100200.
    Citations: 11     Fields:    Translation:Animals
  5. Xia D, Watanabe H, Wu B, Lee SH, Li Y, Tsvetkov E, Bolshakov VY, Shen J, Kelleher RJ. Presenilin-1 knockin mice reveal loss-of-function mechanism for familial Alzheimer's disease. Neuron. 2015 Mar 04; 85(5):967-81. PMID: 25741723.
    Citations: 52     Fields:    Translation:HumansAnimals
  6. Grishchuk Y, Sri S, Rudinskiy N, Ma W, Stember KG, Cottle MW, Sapp E, Difiglia M, Muzikansky A, Betensky RA, Wong AM, Bacskai BJ, Hyman BT, Kelleher RJ, Cooper JD, Slaugenhaupt SA. Behavioral deficits, early gliosis, dysmyelination and synaptic dysfunction in a mouse model of mucolipidosis IV. Acta Neuropathol Commun. 2014 Sep 09; 2:133. PMID: 25200117.
    Citations: 10     Fields:    Translation:AnimalsCells
  7. Heilig EA, Gutti U, Tai T, Shen J, Kelleher RJ. Trans-dominant negative effects of pathogenic PSEN1 mutations on ?-secretase activity and Aß production. J Neurosci. 2013 Jul 10; 33(28):11606-17. PMID: 23843529.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  8. Kelleher RJ, Geigenmüller U, Hovhannisyan H, Trautman E, Pinard R, Rathmell B, Carpenter R, Margulies D. High-throughput sequencing of mGluR signaling pathway genes reveals enrichment of rare variants in autism. PLoS One. 2012; 7(4):e35003. PMID: 22558107.
    Citations: 47     Fields:    Translation:HumansCells
  9. Watanabe H, Xia D, Kanekiyo T, Kelleher RJ, Shen J. Familial frontotemporal dementia-associated presenilin-1 c.548G>T mutation causes decreased mRNA expression and reduced presenilin function in knock-in mice. J Neurosci. 2012 Apr 11; 32(15):5085-96. PMID: 22496554.
    Citations: 7     Fields:    Translation:Animals
  10. Lehman HK, Simpson-Abelson MR, Conway TF, Kelleher RJ, Bernstein JM, Bankert RB. Memory T cells in the chronic inflammatory microenvironment of nasal polyposis are hyporesponsive to signaling through the T cell receptor. J Assoc Res Otolaryngol. 2012 Jun; 13(3):423-35. PMID: 22310933.
    Citations: 1     Fields:    Translation:HumansCells
  11. Bankert RB, Balu-Iyer SV, Odunsi K, Shultz LD, Kelleher RJ, Barnas JL, Simpson-Abelson M, Parsons R, Yokota SJ. Humanized mouse model of ovarian cancer recapitulates patient solid tumor progression, ascites formation, and metastasis. PLoS One. 2011; 6(9):e24420. PMID: 21935406.
    Citations: 34     Fields:    Translation:HumansAnimals
  12. Anguera MC, Ma W, Clift D, Namekawa S, Kelleher RJ, Lee JT. Tsx produces a long noncoding RNA and has general functions in the germline, stem cells, and brain. PLoS Genet. 2011 Sep; 7(9):e1002248. PMID: 21912526.
    Citations: 40     Fields:    Translation:AnimalsCells
  13. Kelleher RJ, Shen J. Genetics. Gamma-secretase and human disease. Science. 2010 Nov 19; 330(6007):1055-6. PMID: 21097925.
    Citations: 16     Fields:    Translation:HumansAnimals
  14. Barnas JL, Simpson-Abelson MR, Brooks SP, Kelleher RJ, Bankert RB. Reciprocal functional modulation of the activation of T lymphocytes and fibroblasts derived from human solid tumors. J Immunol. 2010 Sep 01; 185(5):2681-92. PMID: 20686130.
    Citations: 12     Fields:    Translation:HumansCells
  15. Heilig EA, Xia W, Shen J, Kelleher RJ. A presenilin-1 mutation identified in familial Alzheimer disease with cotton wool plaques causes a nearly complete loss of gamma-secretase activity. J Biol Chem. 2010 Jul 16; 285(29):22350-9. PMID: 20460383.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  16. Tong Y, Yamaguchi H, Giaime E, Boyle S, Kopan R, Kelleher RJ, Shen J. Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of alpha-synuclein, and apoptotic cell death in aged mice. Proc Natl Acad Sci U S A. 2010 May 25; 107(21):9879-84. PMID: 20457918.
    Citations: 160     Fields:    Translation:AnimalsCells
  17. Wines-Samuelson M, Schulte EC, Smith MJ, Aoki C, Liu X, Kelleher RJ, Shen J. Characterization of age-dependent and progressive cortical neuronal degeneration in presenilin conditional mutant mice. PLoS One. 2010 Apr 15; 5(4):e10195. PMID: 20419112.
    Citations: 26     Fields:    Translation:AnimalsCells
  18. Barnas JL, Simpson-Abelson MR, Yokota SJ, Kelleher RJ, Bankert RB. T cells and stromal fibroblasts in human tumor microenvironments represent potential therapeutic targets. Cancer Microenviron. 2010 Mar 31; 3(1):29-47. PMID: 21209773.
    Citations: 18     
  19. Simpson-Abelson MR, Purohit VS, Pang WM, Iyer V, Odunsi K, Demmy TL, Yokota SJ, Loyall JL, Kelleher RJ, Balu-Iyer S, Bankert RB. IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironments. Clin Immunol. 2009 Jul; 132(1):71-82. PMID: 19395317.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  20. Watanabe H, Smith MJ, Heilig E, Beglopoulos V, Kelleher RJ, Shen J. Indirect regulation of presenilins in CREB-mediated transcription. J Biol Chem. 2009 May 15; 284(20):13705-13. PMID: 19289467.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  21. Hilchey SP, Hyrien O, Mosmann TR, Livingstone AM, Friedberg JW, Young F, Fisher RI, Kelleher RJ, Bankert RB, Bernstein SH. Rituximab immunotherapy results in the induction of a lymphoma idiotype-specific T-cell response in patients with follicular lymphoma: support for a "vaccinal effect" of rituximab. Blood. 2009 Apr 16; 113(16):3809-12. PMID: 19196657.
    Citations: 46     Fields:    Translation:HumansCellsCTClinical Trials
  22. Kelleher RJ, Bear MF. The autistic neuron: troubled translation? Cell. 2008 Oct 31; 135(3):401-6. PMID: 18984149.
    Citations: 233     Fields:    Translation:HumansAnimalsCells
  23. Simpson-Abelson MR, Sonnenberg GF, Takita H, Yokota SJ, Conway TF, Kelleher RJ, Shultz LD, Barcos M, Bankert RB. Long-term engraftment and expansion of tumor-derived memory T cells following the implantation of non-disrupted pieces of human lung tumor into NOD-scid IL2Rgamma(null) mice. J Immunol. 2008 May 15; 180(10):7009-18. PMID: 18453623.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  24. Nazareth MR, Broderick L, Simpson-Abelson MR, Kelleher RJ, Yokota SJ, Bankert RB. Characterization of human lung tumor-associated fibroblasts and their ability to modulate the activation of tumor-associated T cells. J Immunol. 2007 May 01; 178(9):5552-62. PMID: 17442937.
    Citations: 50     Fields:    Translation:HumansCells
  25. Shen J, Kelleher RJ. The presenilin hypothesis of Alzheimer's disease: evidence for a loss-of-function pathogenic mechanism. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):403-9. PMID: 17197420.
    Citations: 152     Fields:    Translation:HumansAnimalsCells
  26. Govindarajan A, Kelleher RJ, Tonegawa S. A clustered plasticity model of long-term memory engrams. Nat Rev Neurosci. 2006 Jul; 7(7):575-83. PMID: 16791146.
    Citations: 103     Fields:    Translation:HumansAnimals
  27. Lou Q, Conway TF, Egilmez NK, Loyall JL, Bernstein SH, Kelleher RJ, Bankert RB. B cell tumor vaccine enhanced by covalent attachment of immunoglobulin to surface proteins on dendritic cells. Clin Immunol. 2006 Jan; 118(1):66-76. PMID: 16185929.
    Citations: 1     Fields:    Translation:AnimalsCells
  28. Broderick L, Yokota SJ, Reineke J, Mathiowitz E, Stewart CC, Barcos M, Kelleher RJ, Bankert RB. Human CD4+ effector memory T cells persisting in the microenvironment of lung cancer xenografts are activated by local delivery of IL-12 to proliferate, produce IFN-gamma, and eradicate tumor cells. J Immunol. 2005 Jan 15; 174(2):898-906. PMID: 15634912.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  29. Kelleher RJ, Govindarajan A, Tonegawa S. Translational regulatory mechanisms in persistent forms of synaptic plasticity. Neuron. 2004 Sep 30; 44(1):59-73. PMID: 15450160.
    Citations: 193     Fields:    Translation:HumansAnimalsCells
  30. Saura CA, Choi SY, Beglopoulos V, Malkani S, Zhang D, Shankaranarayana Rao BS, Chattarji S, Kelleher RJ, Kandel ER, Duff K, Kirkwood A, Shen J. Loss of presenilin function causes impairments of memory and synaptic plasticity followed by age-dependent neurodegeneration. Neuron. 2004 Apr 08; 42(1):23-36. PMID: 15066262.
    Citations: 219     Fields:    Translation:Animals
  31. Lou Q, Kelleher RJ, Sette A, Loyall J, Southwood S, Bankert RB, Bernstein SH. Germ line tumor-associated immunoglobulin VH region peptides provoke a tumor-specific immune response without altering the response potential of normal B cells. Blood. 2004 Aug 01; 104(3):752-9. PMID: 15054043.
    Citations: 3     Fields:    Translation:AnimalsCells
  32. Kelleher RJ, Govindarajan A, Jung HY, Kang H, Tonegawa S. Translational control by MAPK signaling in long-term synaptic plasticity and memory. Cell. 2004 Feb 06; 116(3):467-79. PMID: 15016380.
    Citations: 259     Fields:    Translation:AnimalsCells
  33. Sugano M, Conway TF, Kelleher RJ, Sugiyama Y, Chen FA, Bankert RB, Bernstein SH. Human dendritic cells pulsed with autologous Epstein-Barr virus transformed B-cell lymphoblastoid cell (BCL) lysate elicit a BCL specific MHC-class II restricted T-cell response. J Exp Clin Cancer Res. 2001 Jun; 20(2):175-82. PMID: 11484971.
    Citations:    Fields:    Translation:HumansCells
  34. Stephen FD, Kelleher RJ, Langner M, Repasky EA. Dietary fatty acids alter the adhesion properties of lymphocytes to extracellular matrix proteins. Adv Exp Med Biol. 1997; 400B:775-88. PMID: 9547629.
    Citations: 1     Fields:    Translation:AnimalsCells
  35. Kim TK, Hashimoto S, Kelleher RJ, Flanagan PM, Kornberg RD, Horikoshi M, Roeder RG. Effects of activation-defective TBP mutations on transcription initiation in yeast. Nature. 1994 May 19; 369(6477):252-5. PMID: 8183347.
    Citations: 44     Fields:    Translation:AnimalsCells
  36. Flanagan PM, Kelleher RJ, Tschochner H, Sayre MH, Kornberg RD. Simple derivation of TFIID-dependent RNA polymerase II transcription systems from Schizosaccharomyces pombe and other organisms, and factors required for transcriptional activation. Proc Natl Acad Sci U S A. 1992 Aug 15; 89(16):7659-63. PMID: 1502179.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  37. Flanagan PM, Kelleher RJ, Sayre MH, Tschochner H, Kornberg RD. A mediator required for activation of RNA polymerase II transcription in vitro. Nature. 1991 Apr 04; 350(6317):436-8. PMID: 2011193.
    Citations: 113     Fields:    Translation:AnimalsCells
  38. Kelleher RJ, Flanagan PM, Kornberg RD. A novel mediator between activator proteins and the RNA polymerase II transcription apparatus. Cell. 1990 Jun 29; 61(7):1209-15. PMID: 2163759.
    Citations: 144     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.