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Sarah James Hill, M.D., Ph.D.

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Overview
Dr. Sarah Hill, M.D./Ph.D., is a physician scientist in the Department of Medical Oncology at Dana-Farber Cancer Institute. She completed her A.B. at Harvard College, her Ph.D. at Harvard University in the laboratory of Dr. David Livingston at Dana-Farber Cancer Institute, and her M.D. at Harvard Medical School in the Harvard-MIT HST program. She is also a Rhodes Scholar and completed an M.Sc. in biochemistry at Oxford University. Upon graduation from the Harvard M.D./Ph.D. program, she completed a brief clinical residency. She joined the faculty at Dana-Farber as an independent investigator immediately upon completion of her residency without any post-doctoral training and won an NIH Early Independence Award with the support of her Ph.D. mentor.

The Hill lab is part of the Department of Medical Oncology and Division of Molecular and Cellular Oncology at Dana-Farber Cancer Institute. The mission of the Hill Lab is to develop a deep mechanistic understanding of breast, ovarian, and endometrial cancer development and tumor biology which we will harness to make these cancers more manageable diseases for all patients through the development of effective methods of detection, prevention, and treatment. In pursuit of this mission, the Hill lab focuses on understanding the role of the BRCA1 tumor suppressor and cell cycle checkpoints in basic molecular and cellular biology and in breast, ovarian, and endometrial carcinogenesis and tumor biology. We utilize molecular/cellular biology and fluorescence microscopy techniques in breast, endometrial, and ovarian cancer cell lines, patient-derived normal and cancer organoids, and mouse models.

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. DP5OD029637 (HILL, SARAH JAMES) Sep 10, 2020 - Aug 31, 2025
    NIH
    Dissecting the interaction between DNA damage repair defects and the tumor microenvironment
    Role: Principal Investigator
  2. F30CA167895 (HILL, SARAH JAMES) Apr 1, 2012 - Mar 31, 2016
    NIH
    Molecular analysis of the function of BRCA1-TONSL complexes
    Role: Principal Investigator

Bibliographic
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.