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James Anthony Walker, Ph.D.

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Biography
University of Cambridge, UKPhDBiochemistry

Overview

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. NF190084 (SAXENA, RICHA) Nov 1, 2020 - Oct 31, 2023
    Department of Defense (DOD) Neurofibromatosis Research Program (NFRP)
    Longitudinal, objective measurement and analysis of sleep-wake patterns in NF1 patients
    Role: Co-Investigator
  2. R01HL146751 (SAXENA, RICHA) May 15, 2020 - Apr 30, 2024
    NIH
    Dissecting Causal Role of Insomnia in Cardiovascular Disease
    Role: PI
  3. R01GM132825 (CHOUDHARY, AMIT) Sep 1, 2019 - Jul 31, 2023
    NIH
    Development of synthetic gene drives using small molecules
    Role: Co-Principal Investigator
  4. U01CA242098 (WOO, CHRISTINA) Jul 5, 2019 - Jun 30, 2022
    NIH
    Tools to facilitate manipulation of protein-specific glycosylation stoichiometry in cells
    Role: Co-Investigator
  5. CTF (WALKER, JAMES ANTHONY) May 1, 2019 - Oct 31, 2021
    Children’s Tumor Foundation NF1 Gene Therapy Initiative
    Development of NF1 therapeutics with CRISPR-based technologies.
    Role: PI

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Marquilly C, Busto GU, Leger BS, Boulanger A, Giniger E, Walker JA, Fradkin LG, Dura JM. Htt is a repressor of Abl activity required for APP-induced axonal growth. PLoS Genet. 2021 01; 17(1):e1009287. PMID: 33465062.
    Citations:    Fields:    Translation:HumansAnimalsCells
  2. Sreekanth V, Zhou Q, Kokkonda P, Bermudez-Cabrera HC, Lim D, Law BK, Holmes BR, Chaudhary SK, Pergu R, Leger BS, Walker JA, Gifford DK, Sherwood RI, Choudhary A. Chemogenetic System Demonstrates That Cas9 Longevity Impacts Genome Editing Outcomes. ACS Cent Sci. 2020 Dec 23; 6(12):2228-2237. PMID: 33376784.
    Citations:    
  3. King LB, Boto T, Botero V, Aviles AM, Jomsky BM, Joseph C, Walker JA, Tomchik SM. Developmental loss of neurofibromin across distributed neuronal circuits drives excessive grooming in Drosophila. PLoS Genet. 2020 07; 16(7):e1008920. PMID: 32697780.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  4. Moscato EH, Dubowy C, Walker JA, Kayser MS. Social Behavioral Deficits with Loss of Neurofibromin Emerge from Peripheral Chemosensory Neuron Dysfunction. Cell Rep. 2020 07 07; 32(1):107856. PMID: 32640222.
    Citations: 1     Fields:    Translation:AnimalsCells
  5. López Del Amo V, Leger BS, Cox KJ, Gill S, Bishop AL, Scanlon GD, Walker JA, Gantz VM, Choudhary A. Small-Molecule Control of Super-Mendelian Inheritance in Gene Drives. Cell Rep. 2020 06 30; 31(13):107841. PMID: 32610142.
    Citations: 3     Fields:    Translation:Animals
  6. Liu Y, Jordan JT, Bredella MA, Erdin S, Walker JA, Vangel M, Harris GJ, Plotkin SR, Cai W. Correlation between NF1 genotype and imaging phenotype on whole-body MRI: NF1 radiogenomics. Neurology. 2020 06 16; 94(24):e2521-e2531. PMID: 32345730.
    Citations: 1     Fields:    Translation:Humans
  7. Walker JA, Upadhyaya M. Emerging therapeutic targets for neurofibromatosis type 1. Expert Opin Ther Targets. 2018 05; 22(5):419-437. PMID: 29667529.
    Citations: 3     Fields:    Translation:HumansAnimals
  8. Jordan JT, Smith MJ, Walker JA, Erdin S, Talkowski ME, Merker VL, Ramesh V, Cai W, Harris GJ, Bredella MA, Seijo M, Suuberg A, Gusella JF, Plotkin SR. Pain correlates with germline mutation in schwannomatosis. Medicine (Baltimore). 2018 Feb; 97(5):e9717. PMID: 29384852.
    Citations: 3     Fields:    Translation:Humans
  9. Perea D, Guiu J, Hudry B, Konstantinidou C, Milona A, Hadjieconomou D, Carroll T, Hoyer N, Natarajan D, Kallijärvi J, Walker JA, Soba P, Thapar N, Burns AJ, Jensen KB, Miguel-Aliaga I. Ret receptor tyrosine kinase sustains proliferation and tissue maturation in intestinal epithelia. EMBO J. 2017 10 16; 36(20):3029-3045. PMID: 28899900.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  10. Parasuraman P, Mulligan P, Walker JA, Li B, Boukhali M, Haas W, Bernards A. Interaction of p190A RhoGAP with eIF3A and Other Translation Preinitiation Factors Suggests a Role in Protein Biosynthesis. J Biol Chem. 2017 02 17; 292(7):2679-2689. PMID: 28007963.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  11. Dietz KN, Di Stefano L, Maher RC, Zhu H, Macdonald ME, Gusella JF, Walker JA. The Drosophila Huntington's disease gene ortholog dhtt influences chromatin regulation during development. Hum Mol Genet. 2015 Jan 15; 24(2):330-45. PMID: 25168387.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  12. Hutchinson CV, Walker JA, Davidson C. Oestrogen, ocular function and low-level vision: a review. J Endocrinol. 2014 Nov; 223(2):R9-18. PMID: 25143633.
    Citations: 7     Fields:    Translation:Humans
  13. Walker JA, Bernards A. A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth. Rare Dis. 2014; 2:e28341. PMID: 25054093.
    Citations: 1     
  14. Walker JA, Gouzi JY, Long JB, Huang S, Maher RC, Xia H, Khalil K, Ray A, Van Vactor D, Bernards R, Bernards A. Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP/PKA signaling defects in the Drosophila melanogaster neurofibromatosis-1 growth deficiency. PLoS Genet. 2013 Nov; 9(11):e1003958. PMID: 24278035.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  15. Smith MJ, Esparza S, Merker VL, Muzikansky A, Bredella MA, Harris GJ, Kassarjian A, Cai W, Walker JA, Mautner VF, Plotkin SR. Plasma S100ß is not a useful biomarker for tumor burden in neurofibromatosis. Clin Biochem. 2013 May; 46(7-8):698-700. PMID: 23261835.
    Citations: 1     Fields:    Translation:Humans
  16. Tsai PI, Wang M, Kao HH, Cheng YJ, Walker JA, Chen RH, Chien CT. Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. J Neurosci. 2012 Nov 21; 32(47):16971-81. PMID: 23175848.
    Citations: 13     Fields:    Translation:AnimalsCells
  17. Smith MJ, Walker JA, Shen Y, Stemmer-Rachamimov A, Gusella JF, Plotkin SR. Expression of SMARCB1 (INI1) mutations in familial schwannomatosis. Hum Mol Genet. 2012 Dec 15; 21(24):5239-45. PMID: 22949514.
    Citations: 12     Fields:    Translation:HumansCells
  18. Lo Sardo V, Zuccato C, Gaudenzi G, Vitali B, Ramos C, Tartari M, Myre MA, Walker JA, Pistocchi A, Conti L, Valenza M, Drung B, Schmidt B, Gusella J, Zeitlin S, Cotelli F, Cattaneo E. An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin. Nat Neurosci. 2012 May; 15(5):713-21. PMID: 22466506.
    Citations: 23     Fields:    Translation:AnimalsCells
  19. Longworth MS, Walker JA, Anderssen E, Moon NS, Gladden A, Heck MM, Ramaswamy S, Dyson NJ. A shared role for RBF1 and dCAP-D3 in the regulation of transcription with consequences for innate immunity. PLoS Genet. 2012; 8(4):e1002618. PMID: 22496667.
    Citations: 26     Fields:    Translation:AnimalsCells
  20. Miles WO, Dyson NJ, Walker JA. Modeling tumor invasion and metastasis in Drosophila. Dis Model Mech. 2011 Nov; 4(6):753-61. PMID: 21979943.
    Citations: 43     Fields:    Translation:Animals
  21. Gouzi JY, Moressis A, Walker JA, Apostolopoulou AA, Palmer RH, Bernards A, Skoulakis EM. The receptor tyrosine kinase Alk controls neurofibromin functions in Drosophila growth and learning. PLoS Genet. 2011 Sep; 7(9):e1002281. PMID: 21949657.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  22. Di Stefano L, Walker JA, Burgio G, Corona DF, Mulligan P, Näär AM, Dyson NJ. Functional antagonism between histone H3K4 demethylases in vivo. Genes Dev. 2011 Jan 01; 25(1):17-28. PMID: 21205864.
    Citations: 27     Fields:    Translation:AnimalsCells
  23. Gohil VM, Offner N, Walker JA, Sheth SA, Fossale E, Gusella JF, MacDonald ME, Neri C, Mootha VK. Meclizine is neuroprotective in models of Huntington's disease. Hum Mol Genet. 2011 Jan 15; 20(2):294-300. PMID: 20977989.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  24. Walker JA, Bernards A. Drosophila melanogaster neurofibromatosis-1: ROS, not Ras? Nat Genet. 2007 Apr; 39(4):443-5. PMID: 17392804.
    Citations: 3     Fields:    Translation:Animals
  25. Walker JA, Tchoudakova AV, McKenney PT, Brill S, Wu D, Cowley GS, Hariharan IK, Bernards A. Reduced growth of Drosophila neurofibromatosis 1 mutants reflects a non-cell-autonomous requirement for GTPase-Activating Protein activity in larval neurons. Genes Dev. 2006 Dec 01; 20(23):3311-23. PMID: 17114577.
    Citations: 19     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.