Harvard Catalyst Profiles

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James Anthony Walker, Ph.D.

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University of Cambridge, UKPhDBiochemistry


Available: 01/10/22, Expires: 03/01/24

Neurofibromatosis type 1 (NF1) is an autosomal dominantly inherited tumor syndrome, predisposing patients to developing many symptoms including plexiform neurofibromas. Effective therapies for NF1 symptoms are still limited. Our goal is to capitalize on the recent advances in CRISPR-based genome editing technologies to develop therapeutics for individuals with NF1 using both base editing and prime editing to precisely correct NF1 mutations. Student will help design and test potential therapeutic strategies using gene editing in Schwann cell lines. Skills required: pipetting, basic cell culture and/or molecular biology (DNA preparation and manipulation, PCR etc.) Can certainly provide funding for a student for a longer-term project.

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. CTF Gene Therapy Initiative (WALKER, JAMES ANTHONY) Apr 1, 2022 - Mar 31, 2023
    Children’s Tumor Foundation NF1 Gene Therapy Initiative
    Design and Optimization of Gene Therapy Strategies for NF1-associated Tumors
    Role: PI
  2. 521004 (WALKER, JAMES ANTHONY) Dec 1, 2021 - Nov 30, 2024
    Gilbert Family Foundation
    Optimization of Base and Prime Editing Strategies for NF1 Therapeutics
  3. NF190084 (SAXENA, RICHA) Nov 1, 2020 - Oct 31, 2023
    Department of Defense (DOD) Neurofibromatosis Research Program (NFRP)
    Longitudinal, objective measurement and analysis of sleep-wake patterns in NF1 patients
    Role: Co-Investigator
  4. R01HL146751 (SAXENA, RICHA) May 15, 2020 - Apr 30, 2024
    Dissecting Causal Role of Insomnia in Cardiovascular Disease
    Role: PI
  5. R01GM132825 (CHOUDHARY, AMIT) Sep 1, 2019 - Jul 31, 2023
    Development of synthetic gene drives using small molecules
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.