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Jonathan S. Duke-Cohan, Ph.D.

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1983 - 1985
Fellowship, Friends of the Hebrew University of Jerusalem, U.K.
1986 - 1986
Visiting Scholarship, British Council (U.K. Government Funded)
2001 - 2003
Barr Program Investigator in Basic and Innovative Cancer Research, Dana-Farber Cancer Institute
Faculty Medal, 1st Faculty of Medicine, Charles University, Prague, Czech Republic


Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Duke-Cohan JS, Akitsu A, Mallis RJ, Messier CM, Lizotte PH, Aster JC, Hwang W, Lang MJ, Reinherz EL. Pre-T cell receptor self-MHC sampling restricts thymocyte dedifferentiation. Nature. 2023 01; 613(7944):565-574. PMID: 36410718; PMCID: PMC9851994.
    Citations:    Fields:    Translation:AnimalsCells
  2. Busek P, Duke-Cohan JS, Sedo A. Does DPP-IV Inhibition Offer New Avenues for Therapeutic Intervention in Malignant Disease? Cancers (Basel). 2022 Apr 21; 14(9). PMID: 35565202; PMCID: PMC9103952.
    Citations: 4     
  3. Sengupta S, Board NL, Wu F, Moskovljevic M, Douglass J, Zhang J, Reinhold BR, Duke-Cohan J, Yu J, Reed MC, Tabdili Y, Azurmendi A, Fray EJ, Zhang H, Hsiue EH, Jenike K, Ho YC, Gabelli SB, Kinzler KW, Vogelstein B, Zhou S, Siliciano JD, Sadegh-Nasseri S, Reinherz EL, Siliciano RF. TCR-mimic bispecific antibodies to target the HIV-1 reservoir. Proc Natl Acad Sci U S A. 2022 04 12; 119(15):e2123406119. PMID: 35394875; PMCID: PMC9169739.
    Citations: 1     Fields:    Translation:HumansCells
  4. Mallis RJ, Duke-Cohan JS, Das DK, Akitsu A, Luoma AM, Banik D, Stephens HM, Tetteh PW, Castro CD, Krahnke S, Hussey RE, Lawney B, Brazin KN, Reche PA, Hwang W, Adams EJ, Lang MJ, Reinherz EL. Molecular design of the ?dT cell receptor ectodomain encodes biologically fit ligand recognition in the absence of mechanosensing. Proc Natl Acad Sci U S A. 2021 06 29; 118(26). PMID: 34172580.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  5. Mahadevan NR, Knelson EH, Wolff JO, Vajdi A, Saigí M, Campisi M, Hong D, Thai TC, Piel B, Han S, Reinhold BB, Duke-Cohan JS, Poitras MJ, Taus LJ, Lizotte PH, Portell A, Quadros V, Santucci AD, Murayama T, Cañadas I, Kitajima S, Akitsu A, Fridrikh M, Watanabe H, Reardon B, Gokhale PC, Paweletz CP, Awad MM, Van Allen EM, Lako A, Wang XT, Chen B, Hong F, Sholl LM, Tolstorukov MY, Pfaff K, Jänne PA, Gjini E, Edwards R, Rodig S, Reinherz EL, Oser MG, Barbie DA. Intrinsic Immunogenicity of Small Cell Lung Carcinoma Revealed by Its Cellular Plasticity. Cancer Discov. 2021 08; 11(8):1952-1969. PMID: 33707236; PMCID: PMC8338750.
    Citations: 28     Fields:    Translation:HumansAnimals
  6. Li X, Mizsei R, Tan K, Mallis RJ, Duke-Cohan JS, Akitsu A, Tetteh PW, Dubey A, Hwang W, Wagner G, Lang MJ, Arthanari H, Wang JH, Reinherz EL. Pre-T cell receptors topologically sample self-ligands during thymocyte ß-selection. Science. 2021 01 08; 371(6525):181-185. PMID: 33335016; PMCID: PMC8011828.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  7. Azouz A, Duke-Cohan JS. Post-developmental extracellular proteoglycan maintenance in attractin-deficient mice. BMC Res Notes. 2020 Jun 24; 13(1):301. PMID: 32580758; PMCID: PMC7313179.
    Citations:    Fields:    Translation:AnimalsCells
  8. Patsoukis N, Duke-Cohan JS, Chaudhri A, Aksoylar HI, Wang Q, Council A, Berg A, Freeman GJ, Boussiotis VA. Interaction of SHP-2 SH2 domains with PD-1 ITSM induces PD-1 dimerization and SHP-2 activation. Commun Biol. 2020 03 17; 3(1):128. PMID: 32184441.
    Citations: 39     Translation:HumansAnimalsCells
  9. Wickström SL, Lövgren T, Volkmar M, Reinhold B, Duke-Cohan JS, Hartmann L, Rebmann J, Mueller A, Melief J, Maas R, Ligtenberg M, Hansson J, Offringa R, Seliger B, Poschke I, Reinherz EL, Kiessling R. Cancer Neoepitopes for Immunotherapy: Discordance Between Tumor-Infiltrating T Cell Reactivity and Tumor MHC Peptidome Display. Front Immunol. 2019; 10:2766. PMID: 31921104.
    Citations: 9     Fields:    Translation:HumansCells
  10. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL. NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology. J Biomol NMR. 2019 Jul; 73(6-7):319-332. PMID: 30815789.
    Citations: 8     Fields:    Translation:HumansCells
  11. Barrett RDH, Laurent S, Mallarino R, Pfeifer SP, Xu CCY, Foll M, Wakamatsu K, Duke-Cohan JS, Jensen JD, Hoekstra HE. Linking a mutation to survival in wild mice. Science. 2019 02 01; 363(6426):499-504. PMID: 30705186.
    Citations: 46     Fields:    Translation:Animals
  12. Brazin KN, Mallis RJ, Boeszoermenyi A, Feng Y, Yoshizawa A, Reche PA, Kaur P, Bi K, Hussey RE, Duke-Cohan JS, Song L, Wagner G, Arthanari H, Lang MJ, Reinherz EL. The T Cell Antigen Receptor a Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations. Immunity. 2018 11 20; 49(5):829-841.e6. PMID: 30389415.
    Citations: 26     Fields:    Translation:Cells
  13. Duke-Cohan JS, Ishikawa Y, Yoshizawa A, Choi YI, Lee CN, Acuto O, Kissler S, Reinherz EL. Regulation of thymocyte trafficking by Tagap, a GAP domain protein linked to human autoimmunity. Sci Signal. 2018 06 12; 11(534). PMID: 29895617; PMCID: PMC6393939.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  14. Movassagh H, Shan L, Duke-Cohan JS, Chakir J, Halayko AJ, Koussih L, Gounni AS. Downregulation of semaphorin 3E promotes hallmarks of experimental chronic allergic asthma. Oncotarget. 2017 Nov 17; 8(58):98953-98963. PMID: 29228740.
    Citations: 5     Fields:    
  15. Movassagh H, Shan L, Duke-Cohan JS, Halayko AJ, Uzonna JE, Gounni AS. Semaphorin 3E Alleviates Hallmarks of House Dust Mite-Induced Allergic Airway Disease. Am J Pathol. 2017 Jul; 187(7):1566-1576. PMID: 28634005.
    Citations: 13     Fields:    Translation:AnimalsCells
  16. Movassagh H, Saati A, Nandagopal S, Mohammed A, Tatari N, Shan L, Duke-Cohan JS, Fowke KR, Lin F, Gounni AS. Chemorepellent Semaphorin 3E Negatively Regulates Neutrophil Migration In Vitro and In Vivo. J Immunol. 2017 02 01; 198(3):1023-1033. PMID: 27913633.
    Citations: 11     Fields:    Translation:HumansCells
  17. Das DK, Mallis RJ, Duke-Cohan JS, Hussey RE, Tetteh PW, Hilton M, Wagner G, Lang MJ, Reinherz EL. Pre-T Cell Receptors (Pre-TCRs) Leverage Vß Complementarity Determining Regions (CDRs) and Hydrophobic Patch in Mechanosensing Thymic Self-ligands. J Biol Chem. 2016 Dec 02; 291(49):25292-25305. PMID: 27707880.
    Citations: 26     Fields:    Translation:AnimalsCells
  18. Mallis RJ, Bai K, Arthanari H, Hussey RE, Handley M, Li Z, Chingozha L, Duke-Cohan JS, Lu H, Wang JH, Zhu C, Wagner G, Reinherz EL. Pre-TCR ligand binding impacts thymocyte development before aßTCR expression. Proc Natl Acad Sci U S A. 2015 Jul 07; 112(27):8373-8. PMID: 26056289; PMCID: PMC4500245.
    Citations: 34     Fields:    Translation:AnimalsCells
  19. Xiao Y, Yu S, Zhu B, Bedoret D, Bu X, Francisco LM, Hua P, Duke-Cohan JS, Umetsu DT, Sharpe AH, DeKruyff RH, Freeman GJ. RGMb is a novel binding partner for PD-L2 and its engagement with PD-L2 promotes respiratory tolerance. J Exp Med. 2014 May 05; 211(5):943-59. PMID: 24752301.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  20. Choi YI, Duke-Cohan JS, Chen W, Liu B, Rossy J, Tabarin T, Ju L, Gui J, Gaus K, Zhu C, Reinherz EL. Dynamic control of ß1 integrin adhesion by the plexinD1-sema3E axis. Proc Natl Acad Sci U S A. 2014 Jan 07; 111(1):379-84. PMID: 24344262.
    Citations: 32     Fields:    Translation:AnimalsCells
  21. Choi YI, Duke-Cohan JS, Tan J, Gui J, Singh MK, Epstein JA, Reinherz EL. Plxnd1 expression in thymocytes regulates their intrathymic migration while that in thymic endothelium impacts medullary topology. Front Immunol. 2013; 4:392. PMID: 24312099.
    Citations: 7     Fields:    
  22. Naito M, Hainz U, Burkhardt UE, Fu B, Ahove D, Stevenson KE, Rajasagi M, Zhu B, Alonso A, Witten E, Matsuoka K, Neuberg D, Duke-Cohan JS, Wu CJ, Freeman GJ. CD40L-Tri, a novel formulation of recombinant human CD40L that effectively activates B cells. Cancer Immunol Immunother. 2013 Feb; 62(2):347-57. PMID: 22926059.
    Citations: 18     Fields:    Translation:HumansCells
  23. Marina O, Duke-Cohan JS, Wu CJ. A coprecipitation-based validation methodology for interactions identified using protein microarrays. Methods Mol Biol. 2011; 723:239-54. PMID: 21370070.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  24. Marina O, Hainz U, Biernacki MA, Zhang W, Cai A, Duke-Cohan JS, Liu F, Brusic V, Neuberg D, Kutok JL, Alyea EP, Canning CM, Soiffer RJ, Ritz J, Wu CJ. Serologic markers of effective tumor immunity against chronic lymphocytic leukemia include nonmutated B-cell antigens. Cancer Res. 2010 Feb 15; 70(4):1344-55. PMID: 20124481.
    Citations: 21     Fields:    Translation:HumansCells
  25. Krishnaswamy S, Kanteti R, Duke-Cohan JS, Loganathan S, Liu W, Ma PC, Sattler M, Singleton PA, Ramnath N, Innocenti F, Nicolae DL, Ouyang Z, Liang J, Minna J, Kozloff MF, Ferguson MK, Natarajan V, Wang YC, Garcia JG, Vokes EE, Salgia R. Ethnic differences and functional analysis of MET mutations in lung cancer. Clin Cancer Res. 2009 Sep 15; 15(18):5714-23. PMID: 19723643; PMCID: PMC2767337.
    Citations: 93     Fields:    Translation:Humans
  26. Rabinovsky R, Pochanard P, McNear C, Brachmann SM, Duke-Cohan JS, Garraway LA, Sellers WR. p85 Associates with unphosphorylated PTEN and the PTEN-associated complex. Mol Cell Biol. 2009 Oct; 29(19):5377-88. PMID: 19635806.
    Citations: 54     Fields:    Translation:HumansCells
  27. Duke-Cohan, J. Regulation of extracellular proteolysis by CUB-domain containing proteins. FEBS Journal. 2009; 276(Suppl. 1):18.
  28. Grandpre LE, Duke-Cohan JS, Ewald BA, Devoy C, Barouch DH, Letvin NL, Reinherz EL, Baden LR, Dolin R, Seaman MS. Immunogenicity of recombinant Modified Vaccinia Ankara following a single or multi-dose vaccine regimen in rhesus monkeys. Vaccine. 2009 Mar 04; 27(10):1549-56. PMID: 19168105.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  29. Duke-Cohan JS, Wollenick K, Witten EA, Seaman MS, Baden LR, Dolin R, Reinherz EL. The heterogeneity of human antibody responses to vaccinia virus revealed through use of focused protein arrays. Vaccine. 2009 Feb 18; 27(8):1154-65. PMID: 19146908.
    Citations: 14     Fields:    Translation:HumansCells
  30. Choi YI, Duke-Cohan JS, Ahmed WB, Handley MA, Mann F, Epstein JA, Clayton LK, Reinherz EL. PlexinD1 glycoprotein controls migration of positively selected thymocytes into the medulla. Immunity. 2008 Dec 19; 29(6):888-98. PMID: 19027330.
    Citations: 64     Fields:    Translation:AnimalsCells
  31. Sedo A, Stremenová J, Bušek P, Duke-Cohan JS. Dipeptidyl peptidase-IV and related molecules: markers of malignancy? Expert Opin Med Diagn. 2008 Jun; 2(6):677-89. PMID: 23495778.
    Citations: 10     Fields:    
  32. A Šedo, J Stremenová, P Bušek, JS Duke-Cohan. Dipeptidyl peptidase-IV and related molecules: markers of malignancy?. Expert Opinion on Medical Diagnostics. 2008; 6:1691-9.
  33. Duke-Cohan JS, Khwaja FW, van Meir EG. Attractin, neurodegeneration and glioma development. Tumor Biology. 2007; 28(Supplement 1):3.
  34. Romero V, Larsen CE, Duke-Cohan JS, Fox EA, Romero T, Clavijo OP, Fici DA, Husain Z, Almeciga I, Alford DR, Awdeh ZL, Zuñiga J, El-Dahdah L, Alper CA, Yunis EJ. Genetic fixity in the human major histocompatibility complex and block size diversity in the class I region including HLA-E. BMC Genet. 2007 Apr 12; 8:14. PMID: 17430593; PMCID: PMC1853106.
    Citations: 12     Fields:    Translation:HumansCells
  35. Azouz A, Gunn TM, Duke-Cohan JS. Juvenile-onset loss of lipid-raft domains in attractin-deficient mice. Exp Cell Res. 2007 Feb 15; 313(4):761-71. PMID: 17196964.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  36. Khwaja FW, Duke-Cohan JS, Brat DJ, Van Meir EG. Attractin is elevated in the cerebrospinal fluid of patients with malignant astrocytoma and mediates glioma cell migration. Clin Cancer Res. 2006 Nov 01; 12(21):6331-6. PMID: 17085642.
    Citations: 18     Fields:    Translation:Humans
  37. Gudi R, Barkinge J, Hawkins S, Chu F, Manicassamy S, Sun Z, Duke-Cohan JS, Prasad KV. Siva-1 negatively regulates NF-kappaB activity: effect on T-cell receptor-mediated activation-induced cell death (AICD). Oncogene. 2006 Jun 08; 25(24):3458-62. PMID: 16491128.
    Citations: 15     Fields:    Translation:HumansCells
  38. Duke-Cohan JS, Kang H, Liu H, Rudd CE. Regulation and function of SKAP-55 non-canonical motif binding to the SH3c domain of adhesion and degranulation-promoting adaptor protein. J Biol Chem. 2006 May 12; 281(19):13743-13750. PMID: 16461356.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  39. Sedo A, Duke-Cohan JS, Balaziova E, Sedova LR. Dipeptidyl peptidase IV activity and/or structure homologs: contributing factors in the pathogenesis of rheumatoid arthritis? Arthritis Res Ther. 2005; 7(6):253-69. PMID: 16277701; PMCID: PMC1297595.
    Citations: 25     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.