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Gabriel Kreiman, Ph.D.

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Biography
1990
National Math Olympiads
1997
Argentine Chemistry Associtation
2002
Milton Clauser Doctoral Prize
2002
Lawrence Ferguzon Prize
2003 - 2006
MIT Dean of Science Whiteman Award
2007 - 2008
Career Development Award
2008
Klingenstein Fund Award
2008
Whitehall Foundation Award
2009 - 2014
NIH New Innovator Award
2010 - 2014
National Science Foundation Career Award
2015
Pisart Award for Vision Research

Overview
Kreiman Lab Web Site
http://klab.tch.harvard.edu
gabriel.kreiman@tch.harvard.edu

Mentoring
Available: 09/01/19, Expires: 08/31/20

Understand the neuronal circuits and mechanisms for memory formation in the human brain

Available: 09/01/19, Expires: 08/31/20

Build biologically inspired Artificial Intelligence algorithms for visual recognition

Available: 09/01/19, Expires: 08/31/20

This project will focus on understanding the biological codes involved in transcriptional regulation as well as translational regulation. Using computational modeling, high-throughput RNA sequencing data and MS proteomic data, the goal is to unravel the biological mechanisms to control transcription and the relationships between transcript production and protein production.

Available: 09/30/19, Expires: 09/01/20

The small object next to a computer keyboard is most likely to be a computer mouse, not an elephant. In the real world, objects often co-vary with other objects and particular environments. In the project, we have two primary goals. The first is to develop an understanding for the brain’s ability to process and comprehend visual input based on surrounding context through a biological and quantified explanation. In particular, there are eight main experiments that we have tested and plan to test on both humans and machine learning algorithms with regards to the role of context in object recognition, including (a) varying amounts of context shown, (b) backward masking, (c) blurred context, (d) blurred object, (e) scrambling contextual information, (f) guessing objects from contextual information, (g) finding the effects of time on recognition, and (h) swapping context. Each of these experiments are run in-lab using eyetrackers and online through Amazon’s Mechanical Turk. Second, we further hope to utilize this understanding towards building a robust computational model, which would contribute to enabling current technology to identify visual cues more meticulously. A paper related to our project: https://arxiv.org/abs/1902.00163

The position is volunteer. In the project, students, who can commit at least 4 hours a week, will obtain hands-on experiences in designing, developing and implementing psychophysics experiments and acquire skills of using eyetrackers, coding psyschophysics experiments using MATLAB psychotoolbox, and coding online Amazon's Mechanical Turk experiments using HTML and javascript. In subsequent steps, students can also join in developing computational models for object recognition with various machine learning techniques, such as deep learning, on state-of-the-art machine learning platforms, such as tensorflow and pytorch. Moreover, students also have the opportunity to hone their critical thinking ability in analysing scientific results and drawing insightful conclusions based on experimental results.
NO background in computer science or neuroscience is required.


Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21DA042020 (KREIMAN, GABRIEL) Feb 1, 2017 - Jan 31, 2019
    NIH/NIDA
    Neural circuits for cognitive control
    Role: Principal Investigator
  2. R21MH107820 (KREIMAN, GABRIEL) Jun 1, 2016 - May 31, 2018
    NIH/NIMH
    Neural Circuitry of Threat Perception: Implications for Anxiety and Paranoia
    Role: Principal Investigator
  3. R01EY026025 (KREIMAN, GABRIEL) Mar 1, 2016 - Feb 28, 2019
    NIH/NEI
    Neural dynamics underlying spatiotemporal cognitive integration
    Role: Principal Investigator
  4. R01GM112007 (STEEN, JUDITH A.) Apr 1, 2015 - Mar 31, 2019
    NIH/NIGMS
    Proteogenomics to characterize novel non-coding and extragenic translation
    Role: Principal Investigator
  5. R21NS070250 (KREIMAN, GABRIEL) Apr 1, 2011 - Mar 31, 2013
    NIH/NINDS
    Interictal discharge events: from physiological effects to cognitive consequences
    Role: Principal Investigator

Featured Content

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Xiao W, Kreiman G. XDream: Finding preferred stimuli for visual neurons using generative networks and gradient-free optimization. PLoS Comput Biol. 2020 Jun; 16(6):e1007973. PMID: 32542056.
    Citations:    
  2. Ben-Yosef G, Kreiman G, Ullman S. Minimal videos: Trade-off between spatial and temporal information in human and machine vision. Cognition. 2020 Aug; 201:104263. PMID: 32325309.
    Citations:    
  3. Kreiman G, Serre T. Beyond the feedforward sweep: feedback computations in the visual cortex. Ann N Y Acad Sci. 2020 03; 1464(1):222-241. PMID: 32112444.
    Citations:    
  4. Madhavan R, Bansal AK, Madsen JR, Golby AJ, Tierney TS, Eskandar EN, Anderson WS, Kreiman G. Neural Interactions Underlying Visuomotor Associations in the Human Brain. Cereb Cortex. 2019 12 17; 29(11):4551-4567. PMID: 30590542.
    Citations:    Fields:    
  5. Ponce CR, Xiao W, Schade PF, Hartmann TS, Kreiman G, Livingstone MS. Evolving Images for Visual Neurons Using a Deep Generative Network Reveals Coding Principles and Neuronal Preferences. Cell. 2019 05 02; 177(4):999-1009.e10. PMID: 31051108.
    Citations:    
  6. Kreiman G. It's a small dimensional world after all: Comment on "The unreasonable effectiveness of small neural ensembles in high-dimensional brain" by Alexander N. Gorban et al. Phys Life Rev. 2019 07; 29:96-97. PMID: 30948233.
    Citations:    
  7. Misra P, Marconi A, Peterson M, Kreiman G. Minimal memory for details in real life events. Sci Rep. 2018 11 12; 8(1):16701. PMID: 30420740.
    Citations:    Fields:    
  8. Zhang M, Feng J, Ma KT, Lim JH, Zhao Q, Kreiman G. Finding any Waldo with zero-shot invariant and efficient visual search. Nat Commun. 2018 09 13; 9(1):3730. PMID: 30213937.
    Citations:    Fields:    Translation:HumansCells
  9. Tang H, Schrimpf M, Lotter W, Moerman C, Paredes A, Ortega Caro J, Hardesty W, Cox D, Kreiman G. Recurrent computations for visual pattern completion. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):8835-8840. PMID: 30104363.
    Citations:    Fields:    Translation:HumansCTClinical Trials
  10. Palepu A, Premanathan S, Azhar F, Vendrame M, Loddenkemper T, Reinsberger C, Kreiman G, Parkerson KA, Sarma S, Anderson WS. Automating Interictal Spike Detection: Revisiting A Simple Threshold Rule. Conf Proc IEEE Eng Med Biol Soc. 2018 07; 2018:299-302. PMID: 30440397.
    Citations:    Fields:    
  11. Isik L, Singer J, Madsen JR, Kanwisher N, Kreiman G. What is changing when: Decoding visual information in movies from human intracranial recordings. Neuroimage. 2018 10 15; 180(Pt A):147-159. PMID: 28823828.
    Citations:    Fields:    Translation:Humans
  12. Tang H, Singer J, Ison MJ, Pivazyan G, Romaine M, Frias R, Meller E, Boulin A, Carroll J, Perron V, Dowcett S, Arellano M, Kreiman G. Predicting episodic memory formation for movie events. Sci Rep. 2016 Sep 30; 6:30175. PMID: 27686330.
    Citations: 1     Fields:    
  13. Kreiman G. A null model for cortical representations with grandmothers galore. Lang Cogn Neurosci. 2017; 32(3):274-285. PMID: 29204455.
    Citations:    
  14. Gómez-Laberge C, Smolyanskaya A, Nassi JJ, Kreiman G, Born RT. Bottom-Up and Top-Down Input Augment the Variability of Cortical Neurons. Neuron. 2016 Aug 03; 91(3):540-547. PMID: 27427459.
    Citations: 2     Fields:    Translation:AnimalsCells
  15. Tang S, Hemberg M, Cansizoglu E, Belin S, Kosik K, Kreiman G, Steen H, Steen J. f-divergence cutoff index to simultaneously identify differential expression in the integrated transcriptome and proteome. Nucleic Acids Res. 2016 06 02; 44(10):e97. PMID: 26980280.
    Citations:    Fields:    
  16. Tang H, Yu HY, Chou CC, Crone NE, Madsen JR, Anderson WS, Kreiman G. Cascade of neural processing orchestrates cognitive control in human frontal cortex. Elife. 2016 Feb 18; 5. PMID: 26888070.
    Citations: 4     Fields:    Translation:Humans
  17. Miconi T, Groomes L, Kreiman G. There's Waldo! A Normalization Model of Visual Search Predicts Single-Trial Human Fixations in an Object Search Task. Cereb Cortex. 2016 07; 26(7):3064-82. PMID: 26092221.
    Citations: 3     Fields:    Translation:Humans
  18. Madhavan R, Millman D, Tang H, Crone NE, Lenz FA, Tierney TS, Madsen JR, Kreiman G, Anderson WS. Decrease in gamma-band activity tracks sequence learning. Front Syst Neurosci. 2014; 8:222. PMID: 25653598.
    Citations: 1     
  19. Singer JM, Madsen JR, Anderson WS, Kreiman G. Sensitivity to timing and order in human visual cortex. J Neurophysiol. 2015 Mar 01; 113(5):1656-69. PMID: 25429116.
    Citations:    Fields:    Translation:Humans
  20. Prabakaran S, Hemberg M, Chauhan R, Winter D, Tweedie-Cullen RY, Dittrich C, Hong E, Gunawardena J, Steen H, Kreiman G, Steen JA. Quantitative profiling of peptides from RNAs classified as noncoding. Nat Commun. 2014 Nov 18; 5:5429. PMID: 25403355.
    Citations: 11     Fields:    Translation:AnimalsCells
  21. Tang H, Buia C, Madhavan R, Crone NE, Madsen JR, Anderson WS, Kreiman G. Spatiotemporal dynamics underlying object completion in human ventral visual cortex. Neuron. 2014 Aug 06; 83(3):736-48. PMID: 25043420.
    Citations: 11     Fields:    Translation:Humans
  22. Nassi JJ, Gómez-Laberge C, Kreiman G, Born RT. Corticocortical feedback increases the spatial extent of normalization. Front Syst Neurosci. 2014; 8:105. PMID: 24910596.
    Citations: 9     
  23. Singer JM, Kreiman G. Short temporal asynchrony disrupts visual object recognition. J Vis. 2014 May 12; 14(5):7. PMID: 24819738.
    Citations: 3     Fields:    Translation:HumansCells
  24. Bansal AK, Madhavan R, Agam Y, Golby A, Madsen JR, Kreiman G. Neural dynamics underlying target detection in the human brain. J Neurosci. 2014 Feb 19; 34(8):3042-55. PMID: 24553944.
    Citations: 3     Fields:    Translation:Humans
  25. Murugan R, Kreiman G. Theory on the coupled stochastic dynamics of transcription and splice-site recognition. PLoS Comput Biol. 2012; 8(11):e1002747. PMID: 23133354.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  26. Bansal AK, Singer JM, Anderson WS, Golby A, Madsen JR, Kreiman G. Temporal stability of visually selective responses in intracranial field potentials recorded from human occipital and temporal lobes. J Neurophysiol. 2012 Dec; 108(11):3073-86. PMID: 22956795.
    Citations: 3     Fields:    Translation:Humans
  27. Hemberg M, Gray JM, Cloonan N, Kuersten S, Grimmond S, Greenberg ME, Kreiman G. Integrated genome analysis suggests that most conserved non-coding sequences are regulatory factor binding sites. Nucleic Acids Res. 2012 Sep; 40(16):7858-69. PMID: 22684627.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  28. Burbank KS, Kreiman G. Depression-biased reverse plasticity rule is required for stable learning at top-down connections. PLoS Comput Biol. 2012; 8(3):e1002393. PMID: 22396630.
    Citations: 2     Fields:    Translation:HumansCells
  29. Kreiman G, Maunsell JH. Nine criteria for a measure of scientific output. Front Comput Neurosci. 2011; 5:48. PMID: 22102840.
    Citations: 11     
  30. Tang H, Kreiman G. Face recognition: vision and emotions beyond the bubble. Curr Biol. 2011 Nov 08; 21(21):R888-90. PMID: 22075428.
    Citations:    Fields:    Translation:HumansCells
  31. Murugan R, Kreiman G. On the minimization of fluctuations in the response times of autoregulatory gene networks. Biophys J. 2011 Sep 21; 101(6):1297-306. PMID: 21943410.
    Citations: 8     Fields:    
  32. Hemberg M, Kreiman G. Conservation of transcription factor binding events predicts gene expression across species. Nucleic Acids Res. 2011 Sep 01; 39(16):7092-102. PMID: 21622661.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  33. Fried I, Mukamel R, Kreiman G. Internally generated preactivation of single neurons in human medial frontal cortex predicts volition. Neuron. 2011 Feb 10; 69(3):548-62. PMID: 21315264.
    Citations: 56     Fields:    Translation:HumansCells
  34. Anderson WS, Kreiman G. Neuroscience: what we cannot model, we do not understand. Curr Biol. 2011 Feb 08; 21(3):R123-5. PMID: 21300278.
    Citations:    Fields:    Translation:Animals
  35. Kreiman G. Decoding ensemble activity from neurophysiological recordings in the temporal cortex. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:5904-7. PMID: 22255683.
    Citations:    Fields:    Translation:Humans
  36. Blumberg J, Kreiman G. How cortical neurons help us see: visual recognition in the human brain. J Clin Invest. 2010 Sep; 120(9):3054-63. PMID: 20811161.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  37. Agam Y, Liu H, Papanastassiou A, Buia C, Golby AJ, Madsen JR, Kreiman G. Robust selectivity to two-object images in human visual cortex. Curr Biol. 2010 May 11; 20(9):872-9. PMID: 20417105.
    Citations: 14     Fields:    Translation:Humans
  38. Kim TK, Hemberg M, Gray JM, Costa AM, Bear DM, Wu J, Harmin DA, Laptewicz M, Barbara-Haley K, Kuersten S, Markenscoff-Papadimitriou E, Kuhl D, Bito H, Worley PF, Kreiman G, Greenberg ME. Widespread transcription at neuronal activity-regulated enhancers. Nature. 2010 May 13; 465(7295):182-7. PMID: 20393465.
    Citations: 787     Fields:    Translation:AnimalsCells
  39. Quian Quiroga R, Kreiman G. Measuring sparseness in the brain: comment on Bowers (2009). Psychol Rev. 2010 Jan; 117(1):291-7. PMID: 20063978.
    Citations: 6     Fields:    Translation:Humans
  40. Singer J, Kreiman G. Toward unmasking the dynamics of visual perception. Neuron. 2009 Nov 25; 64(4):446-7. PMID: 19945387.
    Citations: 1     Fields:    Translation:HumansAnimals
  41. Rasch M, Logothetis NK, Kreiman G. From neurons to circuits: linear estimation of local field potentials. J Neurosci. 2009 Nov 04; 29(44):13785-96. PMID: 19889990.
    Citations: 32     Fields:    Translation:AnimalsCells
  42. Liu H, Agam Y, Madsen JR, Kreiman G. Timing, timing, timing: fast decoding of object information from intracranial field potentials in human visual cortex. Neuron. 2009 Apr 30; 62(2):281-90. PMID: 19409272.
    Citations: 89     Fields:    Translation:Humans
  43. Meyers EM, Freedman DJ, Kreiman G, Miller EK, Poggio T. Dynamic population coding of category information in inferior temporal and prefrontal cortex. J Neurophysiol. 2008 Sep; 100(3):1407-19. PMID: 18562555.
    Citations: 83     Fields:    Translation:AnimalsCells
  44. Kreiman G. Single unit approaches to human vision and memory. Curr Opin Neurobiol. 2007 Aug; 17(4):471-5. PMID: 17703936.
    Citations: 9     Fields:    Translation:HumansCells
  45. Leamey CA, Glendining KA, Kreiman G, Kang ND, Wang KH, Fassler R, Sawatari A, Tonegawa S, Sur M. Differential gene expression between sensory neocortical areas: potential roles for Ten_m3 and Bcl6 in patterning visual and somatosensory pathways. Cereb Cortex. 2008 Jan; 18(1):53-66. PMID: 17478416.
    Citations: 22     Fields:    Translation:Animals
  46. Serre T, Kreiman G, Kouh M, Cadieu C, Knoblich U, Poggio T. A quantitative theory of immediate visual recognition. Prog Brain Res. 2007; 165:33-56. PMID: 17925239.
    Citations: 32     Fields:    Translation:HumansAnimals
  47. Tropea D, Kreiman G, Lyckman A, Mukherjee S, Yu H, Horng S, Sur M. Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. Nat Neurosci. 2006 May; 9(5):660-8. PMID: 16633343.
    Citations: 79     Fields:    Translation:AnimalsCells
  48. Kreiman G, Hung CP, Kraskov A, Quiroga RQ, Poggio T, DiCarlo JJ. Object selectivity of local field potentials and spikes in the macaque inferior temporal cortex. Neuron. 2006 Feb 02; 49(3):433-45. PMID: 16446146.
    Citations: 86     Fields:    Translation:Animals
  49. Hung CP, Kreiman G, Poggio T, DiCarlo JJ. Fast readout of object identity from macaque inferior temporal cortex. Science. 2005 Nov 04; 310(5749):863-6. PMID: 16272124.
    Citations: 191     Fields:    Translation:AnimalsCells
  50. Quiroga RQ, Reddy L, Kreiman G, Koch C, Fried I. Invariant visual representation by single neurons in the human brain. Nature. 2005 Jun 23; 435(7045):1102-7. PMID: 15973409.
    Citations: 288     Fields:    Translation:HumansCells
  51. Yeo G, Holste D, Kreiman G, Burge CB. Variation in alternative splicing across human tissues. Genome Biol. 2004; 5(10):R74. PMID: 15461793.
    Citations: 173     Fields:    Translation:HumansCells
  52. Crick F, Koch C, Kreiman G, Fried I. Consciousness and neurosurgery. Neurosurgery. 2004 Aug; 55(2):273-281; discussion 281-2. PMID: 15271233.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  53. Kreiman G. Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes. Nucleic Acids Res. 2004; 32(9):2889-900. PMID: 15155858.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  54. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, Zhang J, Soden R, Hayakawa M, Kreiman G, Cooke MP, Walker JR, Hogenesch JB. A gene atlas of the mouse and human protein-encoding transcriptomes. Proc Natl Acad Sci U S A. 2004 Apr 20; 101(16):6062-7. PMID: 15075390.
    Citations: 1579     Fields:    Translation:HumansAnimalsCells
  55. Kreiman G, Fried I, Koch C. Single-neuron correlates of subjective vision in the human medial temporal lobe. Proc Natl Acad Sci U S A. 2002 Jun 11; 99(12):8378-83. PMID: 12034865.
    Citations: 37     Fields:    Translation:HumansCells
  56. Rees G, Kreiman G, Koch C. Neural correlates of consciousness in humans. Nat Rev Neurosci. 2002 Apr; 3(4):261-70. PMID: 11967556.
    Citations: 117     Fields:    Translation:HumansAnimalsCells
  57. Krahe R, Kreiman G, Gabbiani F, Koch C, Metzner W. Stimulus encoding and feature extraction by multiple sensory neurons. J Neurosci. 2002 Mar 15; 22(6):2374-82. PMID: 11896176.
    Citations: 14     Fields:    Translation:AnimalsCells
  58. Zirlinger M, Kreiman G, Anderson DJ. Amygdala-enriched genes identified by microarray technology are restricted to specific amygdaloid subnuclei. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5270-5. PMID: 11320257.
    Citations: 47     Fields:    Translation:Animals
  59. Kreiman G, Koch C, Fried I. Imagery neurons in the human brain. Nature. 2000 Nov 16; 408(6810):357-61. PMID: 11099042.
    Citations: 62     Fields:    Translation:HumansCells
  60. Kreiman G, Koch C, Fried I. Category-specific visual responses of single neurons in the human medial temporal lobe. Nat Neurosci. 2000 Sep; 3(9):946-53. PMID: 10966627.
    Citations: 98     Fields:    Translation:HumansCells
  61. Ouyang Y, Rosenstein A, Kreiman G, Schuman EM, Kennedy MB. Tetanic stimulation leads to increased accumulation of Ca(2+)/calmodulin-dependent protein kinase II via dendritic protein synthesis in hippocampal neurons. J Neurosci. 1999 Sep 15; 19(18):7823-33. PMID: 10479685.
    Citations: 61     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.