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profileClyde S. Crumpacker II, M.D.

TitleProfessor of Medicine
InstitutionBeth Israel Deaconess Medical Center
DepartmentMedicine
AddressBeth Israel Deaconess Med Ctr
Infectious Disease
330 Brookline Ave
Boston MA 02215
Phone617/667-3661
Fax617/667-5541
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Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R01HL071859     (CRUMPACKER, CLYDE S)Sep 30, 2002 - Aug 31, 2007
NIH/NHLBI
Mechanisms of Vascular Injury By HCMV
Role: Principal Investigator

R01AI041690     (CRUMPACKER, CLYDE S)Sep 1, 1997 - Aug 31, 2001
NIH/NIAID
CMV RESISTANCE, VIRAL BURDEN AND CLINICAL PROGRESSION
Role: Principal Investigator

R01AI029173     (CRUMPACKER, CLYDE S)Sep 30, 1989 - Jul 31, 1995
NIH/NIAID
RESISTANCE OF HIV TO DRUGS IN PATIENTS AND IN CLONED RT
Role: Principal Investigator

P50HL033774     Sep 30, 1985 - Dec 31, 1996
NIH/NHLBI
MARKERS FOR HUMAN T-CELL LEUKEMIA VIRUS INFECTION
Role: Co-Principal Investigator

M01RR001032     (SUKHATME, VIKAS P)Dec 1, 1977 - Mar 31, 2010
NIH/NCRR
General Clinical Research Center
Role: Co-Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Zhang J, Crumpacker CS. Toward a Cure: Does Host Immunity Play a Role? mSphere. 2017 Mar-Apr; 2(2). PMID: 28497113.
    View in: PubMed
  2. Zhang J, Crumpacker C. Hematopoietic Stem and Immune Cells in Chronic HIV Infection. Stem Cells Int. 2015; 2015:148064. PMID: 26300920; PMCID: PMC4537765.
  3. Zhang J, Crumpacker C. Eradication of HIV and Cure of AIDS, Now and How? Front Immunol. 2013 Oct 18; 4:337. PMID: 24151495; PMCID: PMC3799464.
  4. Zhang J, Poznansky M, Crumpacker C. Naive and memory CD4? T cells in HIV eradication and immunization. J Infect Dis. 2012 Aug 15; 206(4):617-8; author reply 618. PMID: 22696498.
    View in: PubMed
  5. Crumpacker CS. Absence of exposure to varicella does not increase the risk of zoster. Clin Infect Dis. 2011 Sep; 53(5):411-2. PMID: 21844023.
    View in: PubMed
  6. Dudek TE, Torres-Lopez E, Crumpacker C, Knipe DM. Evidence for differences in immunologic and pathogenesis properties of herpes simplex virus 2 strains from the United States and South Africa. J Infect Dis. 2011 May 15; 203(10):1434-41. PMID: 21498376; PMCID: PMC3080912.
  7. Chunduri H, Crumpacker C, Sharma PL. Reverse transcriptase mutation K65N confers a decreased replication capacity to HIV-1 in comparison to K65R due to a decreased RT processivity. Virology. 2011 May 25; 414(1):34-41. PMID: 21459401.
    View in: PubMed
  8. Chunduri H, Rimland D, Nurpeisov V, Crumpacker CS, Sharma PL. A Leu to Ile but not Leu to Val change at HIV-1 reverse transcriptase codon 74 in the background of K65R mutation leads to an increased processivity of K65R+L74I enzyme and a replication competent virus. Virol J. 2011 Jan 21; 8:33. PMID: 21255423; PMCID: PMC3038945.
  9. Crumpacker CS. Invited commentary: human cytomegalovirus, inflammation, cardiovascular disease, and mortality. Am J Epidemiol. 2010 Aug 15; 172(4):372-4. PMID: 20660119.
    View in: PubMed
  10. Zhang J, Crumpacker CS. Hematopoietic stem and progenitor cells in HIV/AIDS and immune reconstitution. Cell Res. 2010 Jul; 20(7):745-7. PMID: 20567263.
    View in: PubMed
  11. Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD, Campbell H, Strohmaier KM, Wan H, Danovich RM, Teppler H. Sustained antiretroviral effect of raltegravir after 96 weeks of combination therapy in treatment-naive patients with HIV-1 infection. J Acquir Immune Defic Syndr. 2009 Nov 01; 52(3):350-6. PMID: 19648823.
    View in: PubMed
  12. Cheng J, Ke Q, Jin Z, Wang H, Kocher O, Morgan JP, Zhang J, Crumpacker CS. Cytomegalovirus infection causes an increase of arterial blood pressure. PLoS Pathog. 2009 May; 5(5):e1000427. PMID: 19436702; PMCID: PMC2673691.
  13. Wohl DA, Kendall MA, Andersen J, Crumpacker C, Spector SA, Feinberg J, Alston-Smith B, Owens S, Chafey S, Marco M, Maxwell S, Lurain N, Jabs D, Benson C, Keiser P, Jacobson MA. Low rate of CMV end-organ disease in HIV-infected patients despite low CD4+ cell counts and CMV viremia: results of ACTG protocol A5030. HIV Clin Trials. 2009 May-Jun; 10(3):143-52. PMID: 19632953; PMCID: PMC2754189.
  14. Crumpacker CS. Valganciclovir and human herpesvirus-8. J Infect Dis. 2008 Jul 01; 198(1):6-7. PMID: 18491975.
    View in: PubMed
  15. Markowitz M, Nguyen BY, Gotuzzo E, Mendo F, Ratanasuwan W, Kovacs C, Prada G, Morales-Ramirez JO, Crumpacker CS, Isaacs RD, Gilde LR, Wan H, Miller MD, Wenning LA, Teppler H. Rapid and durable antiretroviral effect of the HIV-1 Integrase inhibitor raltegravir as part of combination therapy in treatment-naive patients with HIV-1 infection: results of a 48-week controlled study. J Acquir Immune Defic Syndr. 2007 Oct 01; 46(2):125-33. PMID: 17721395.
    View in: PubMed
  16. Zhang J, Scadden DT, Crumpacker CS. Primitive hematopoietic cells resist HIV-1 infection via p21. J Clin Invest. 2007 Feb; 117(2):473-81. PMID: 17273559; PMCID: PMC1783820.
  17. Zhang J, Attar E, Cohen K, Crumpacker C, Scadden D. Silencing p21(Waf1/Cip1/Sdi1) expression increases gene transduction efficiency in primitive human hematopoietic cells. Gene Ther. 2005 Oct; 12(19):1444-52. PMID: 15877047.
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  18. Wang JF, Meissner A, Malek S, Chen Y, Ke Q, Zhang J, Chu V, Hampton TG, Crumpacker CS, Abelmann WH, Amende I, Morgan JP. Propranolol ameliorates and epinephrine exacerbates progression of acute and chronic viral myocarditis. Am J Physiol Heart Circ Physiol. 2005 Oct; 289(4):H1577-83. PMID: 15923319.
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  19. Crumpacker CS. Mixed glycoprotein B genotypes of cytomegalovirus and immunosuppression. Clin Infect Dis. 2004 Jul 15; 39(2):162-4. PMID: 15307022.
    View in: PubMed
  20. Crumpacker CS. Use of antiviral drugs to prevent herpesvirus transmission. N Engl J Med. 2004 Jan 01; 350(1):67-8. PMID: 14702430.
    View in: PubMed
  21. Crumpacker C. Current topics in herpes research. Herpes. 2003 Dec; 10(3):59. PMID: 14759336.
    View in: PubMed
  22. Crumpacker CS, Gonzalez RG, Makar RS. Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 26-2003. A 50-year-old Colombian man with fever and seizures. N Engl J Med. 2003 Aug 21; 349(8):789-96. PMID: 12930932.
    View in: PubMed
  23. Caliendo AM, Yen-Lieberman B, Baptista J, Andersen J, Crumpacker C, Schuurman R, Spector SA, Bremer J, Lurain NS. Comparison of molecular tests for detection and quantification of cell-associated cytomegalovirus DNA. J Clin Microbiol. 2003 Aug; 41(8):3509-13. PMID: 12904347; PMCID: PMC179805.
  24. Weinberg A, Jabs DA, Chou S, Martin BK, Lurain NS, Forman MS, Crumpacker C. Mutations conferring foscarnet resistance in a cohort of patients with acquired immunodeficiency syndrome and cytomegalovirus retinitis. J Infect Dis. 2003 Mar 01; 187(5):777-84. PMID: 12599051.
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  25. Dezube BJ, Proper J, Zhang J, Choy VJ, Weeden W, Morrissey J, Burns EM, Dixon JD, O'Loughlin C, Williams LA, Pickering PJ, Crumpacker CS, Gelder FB. A passive immunotherapy, (PE)HRG214, in patients infected with human immunodeficiency virus: a phase I study. J Infect Dis. 2003 Feb 01; 187(3):500-3. PMID: 12552435.
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  26. Zhang J, Crumpacker CS. Human immunodeficiency virus type 1 nucleocapsid protein nuclear localization mediates early viral mRNA expression. J Virol. 2002 Oct; 76(20):10444-54. PMID: 12239321; PMCID: PMC136591.
  27. Crumpacker CS, Schaffer PA. New anti-HSV therapeutics target the helicase-primase complex. Nat Med. 2002 Apr; 8(4):327-8. PMID: 11927930.
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  28. Wang JF, Zhang J, Min JY, Sullivan MF, Crumpacker CS, Abelmann WH, Morgan JP. Cocaine enhances myocarditis induced by encephalomyocarditis virus in murine model. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H956-63. PMID: 11834492.
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  29. Zhang J, Crumpacker CS. Human immunodeficiency virus type 1 RNA in peripheral blood mononuclear cells of patients receiving prolonged highly active antiretroviral therapy. J Infect Dis. 2001 Nov 15; 184(10):1341-4. PMID: 11679927.
    View in: PubMed
  30. Lurain NS, Weinberg A, Crumpacker CS, Chou S. Sequencing of cytomegalovirus UL97 gene for genotypic antiviral resistance testing. Antimicrob Agents Chemother. 2001 Oct; 45(10):2775-80. PMID: 11557468; PMCID: PMC90730.
  31. Caliendo AM, Schuurman R, Yen-Lieberman B, Spector SA, Andersen J, Manjiry R, Crumpacker C, Lurain NS, Erice A. Comparison of quantitative and qualitative PCR assays for cytomegalovirus DNA in plasma. J Clin Microbiol. 2001 Apr; 39(4):1334-8. PMID: 11283052; PMCID: PMC87935.
  32. Dezube BJ, Dahl TA, Wong TK, Chapman B, Ono M, Yamaguchi N, Gillies SD, Chen LB, Crumpacker CS. A fusion inhibitor (FP-21399) for the treatment of human immunodeficiency virus infection: a phase I study. J Infect Dis. 2000 Aug; 182(2):607-10. PMID: 10915097.
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  33. Oram RJ, Marcellino D, Strauss D, Gustafson E, Talarico CL, Root AK, Sharma PL, Thompson K, Fingeroth JD, Crumpacker C, Herold BC. Characterization of an acyclovir-resistant herpes simplex virus type 2 strain isolated from a premature neonate. J Infect Dis. 2000 Apr; 181(4):1458-61. PMID: 10762577.
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  34. Zhang JL, Sharma PL, Crumpacker CS. Enhancement of the basal-level activity of HIV-1 long terminal repeat by HIV-1 nucleocapsid protein. Virology. 2000 Mar 15; 268(2):251-63. PMID: 10704334.
    View in: PubMed
  35. Landry ML, Stanat S, Biron K, Brambilla D, Britt W, Jokela J, Chou S, Drew WL, Erice A, Gilliam B, Lurain N, Manischewitz J, Miner R, Nokta M, Reichelderfer P, Spector S, Weinberg A, Yen-Lieberman B, Crumpacker C. A standardized plaque reduction assay for determination of drug susceptibilities of cytomegalovirus clinical isolates. Antimicrob Agents Chemother. 2000 Mar; 44(3):688-92. PMID: 10681339; PMCID: PMC89747.
  36. Sharma PL, Crumpacker CS. Decreased processivity of human immunodeficiency virus type 1 reverse transcriptase (RT) containing didanosine-selected mutation Leu74Val: a comparative analysis of RT variants Leu74Val and lamivudine-selected Met184Val. J Virol. 1999 Oct; 73(10):8448-56. PMID: 10482597; PMCID: PMC112864.
  37. Chou S, Lurain NS, Weinberg A, Cai GY, Sharma PL, Crumpacker CS. Interstrain variation in the human cytomegalovirus DNA polymerase sequence and its effect on genotypic diagnosis of antiviral drug resistance. Adult AIDS Clinical Trials Group CMV Laboratories. Antimicrob Agents Chemother. 1999 Jun; 43(6):1500-2. PMID: 10348781; PMCID: PMC89307.
  38. Gulick RM, McAuliffe V, Holden-Wiltse J, Crumpacker C, Liebes L, Stein DS, Meehan P, Hussey S, Forcht J, Valentine FT. Phase I studies of hypericin, the active compound in St. John's Wort, as an antiretroviral agent in HIV-infected adults. AIDS Clinical Trials Group Protocols 150 and 258. Ann Intern Med. 1999 Mar 16; 130(6):510-4. PMID: 10075619.
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  39. McSharry JJ, Lurain NS, Drusano GL, Landay AL, Notka M, O'Gorman MR, Weinberg A, Shapiro HM, Reichelderfer PS, Crumpacker CS. Rapid ganciclovir susceptibility assay using flow cytometry for human cytomegalovirus clinical isolates. Antimicrob Agents Chemother. 1998 Sep; 42(9):2326-31. PMID: 9736557; PMCID: PMC105827.
  40. Schmitz JE, Forman MA, Lifton MA, Concepción O, Reimann KA, Crumpacker CS, Daley JF, Gelman RS, Letvin NL. Expression of the CD8alpha beta-heterodimer on CD8(+) T lymphocytes in peripheral blood lymphocytes of human immunodeficiency virus- and human immunodeficiency virus+ individuals. Blood. 1998 Jul 01; 92(1):198-206. PMID: 9639517.
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  41. Zhang JL, Choe H, Dezube BJ, Farzan M, Sharma PL, Zhou XC, Chen LB, Ono M, Gillies S, Wu Y, Sodroski JG, Crumpacker CS. The bis-azo compound FP-21399 inhibits HIV-1 replication by preventing viral entry. Virology. 1998 May 10; 244(2):530-41. PMID: 9601521.
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  42. Gnann JW, Crumpacker CS, Lalezari JP, Smith JA, Tyring SK, Baum KF, Borucki MJ, Joseph WP, Mertz GJ, Steigbigel RT, Cloud GA, Soong SJ, Sherrill LC, DeHertogh DA, Whitley RJ. Sorivudine versus acyclovir for treatment of dermatomal herpes zoster in human immunodeficiency virus-infected patients: results from a randomized, controlled clinical trial. Collaborative Antiviral Study Group/AIDS Clinical Trials Group, Herpes Zoster Study Group. Antimicrob Agents Chemother. 1998 May; 42(5):1139-45. PMID: 9593141; PMCID: PMC105759.
  43. McSharry JM, Lurain NS, Drusano GL, Landay A, Manischewitz J, Nokta M, O'Gorman M, Shapiro HM, Weinberg A, Reichelderfer P, Crumpacker C. Flow cytometric determination of ganciclovir susceptibilities of human cytomegalovirus clinical isolates. J Clin Microbiol. 1998 Apr; 36(4):958-64. PMID: 9542916; PMCID: PMC104668.
  44. Sharma PL, Crumpacker CS. Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation. J Virol. 1997 Nov; 71(11):8846-51. PMID: 9343245; PMCID: PMC192351.
  45. Dezube BJ, Lederman MM, Chapman B, Georges DL, Dogon AL, Mudido P, Reis-Lishing J, Cheng SL, Silberman SL, Crumpacker CS. The effect of tenidap on cytokines, acute-phase proteins, and virus load in human immunodeficiency virus (HIV)-infected patients: correlation between plasma HIV-1 RNA and proinflammatory cytokine levels. J Infect Dis. 1997 Sep; 176(3):807-10. PMID: 9291340.
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  46. Zhang JL, Sharma PL, Li CJ, Dezube BJ, Pardee AB, Crumpacker CS. Topotecan inhibits human immunodeficiency virus type 1 infection through a topoisomerase-independent mechanism in a cell line with altered topoisomerase I. Antimicrob Agents Chemother. 1997 May; 41(5):977-81. PMID: 9145855; PMCID: PMC163836.
  47. Zhang LJ, Waters CA, Poisson LR, Estis LF, Crumpacker CS. The interleukin-2 fusion protein, DAB389IL-2, inhibits the development of infectious virus in human immunodeficiency virus type 1-infected human peripheral blood mononuclear cells. J Infect Dis. 1997 Apr; 175(4):790-4. PMID: 9086131.
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  48. Balfour HH, Fletcher CV, Erice A, Henry WK, Acosta EP, Smith SA, Holm MA, Boivin G, Shepp DH, Crumpacker CS, Eaton CA, Martin-Munley SS. Effect of foscarnet on quantities of cytomegalovirus and human immunodeficiency virus in blood of persons with AIDS. Antimicrob Agents Chemother. 1996 Dec; 40(12):2721-6. PMID: 9124829; PMCID: PMC163610.
  49. Japour AJ, Lertora JJ, Meehan PM, Erice A, Connor JD, Griffith BP, Clax PA, Holden-Wiltse J, Hussey S, Walesky M, Cooney E, Pollard R, Timpone J, McLaren C, Johanneson N, Wood K, Booth D, Bassiakos Y, Crumpacker CS. A phase-I study of the safety, pharmacokinetics, and antiviral activity of combination didanosine and ribavirin in patients with HIV-1 disease. AIDS Clinical Trials Group 231 Protocol Team. J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Nov 01; 13(3):235-46. PMID: 8898668.
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  50. Coombs RW, Welles SL, Hooper C, Reichelderfer PS, D'Aquila RT, Japour AJ, Johnson VA, Kuritzkes DR, Richman DD, Kwok S, Todd J, Jackson JB, DeGruttola V, Crumpacker CS, Kahn J. Association of plasma human immunodeficiency virus type 1 RNA level with risk of clinical progression in patients with advanced infection. AIDS Clinical Trials Group (ACTG) 116B/117 Study Team. ACTG Virology Committee Resistance and HIV-1 RNA Working Groups. J Infect Dis. 1996 Oct; 174(4):704-12. PMID: 8843206.
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  51. Welles SL, Jackson JB, Yen-Lieberman B, Demeter L, Japour AJ, Smeaton LM, Johnson VA, Kuritzkes DR, D'Aquila RT, Reichelderfer PA, Richman DD, Reichman R, Fischl M, Dolin R, Coombs RW, Kahn JO, McLaren C, Todd J, Kwok S, Crumpacker CS. Prognostic value of plasma human immunodeficiency virus type 1 (HIV-1) RNA levels in patients with advanced HIV-1 disease and with little or no prior zidovudine therapy. AIDS Clinical Trials Group Protocol 116A/116B/117 Team. J Infect Dis. 1996 Oct; 174(4):696-703. PMID: 8843205.
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  52. Sharma PL, Chatis PA, Dogon AL, Mayers DL, McCutchan FE, Page C, Crumpacker CS. AZT-related mutation Lys70Arg in reverse transcriptase of human immunodeficiency virus type 1 confers decrease in susceptibility to ddATP in in vitro RT inhibition assay. Virology. 1996 Sep 15; 223(2):365-9. PMID: 8806572.
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  53. Crumpacker CS. Ganciclovir. N Engl J Med. 1996 Sep 05; 335(10):721-9. PMID: 8786764.
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  54. Crumpacker C. The pharmacological profile of famciclovir. Semin Dermatol. 1996 Jun; 15(2 Suppl 1):14-26. PMID: 8840412.
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  55. Drew WL, Ives D, Lalezari JP, Crumpacker C, Follansbee SE, Spector SA, Benson CA, Friedberg DN, Hubbard L, Stempien MJ, et al. Oral ganciclovir as maintenance treatment for cytomegalovirus retinitis in patients with AIDS. Syntex Cooperative Oral Ganciclovir Study Group. N Engl J Med. 1995 Sep 07; 333(10):615-20. PMID: 7637721.
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  56. Japour AJ, Welles S, D'Aquila RT, Johnson VA, Richman DD, Coombs RW, Reichelderfer PS, Kahn JO, Crumpacker CS, Kuritzkes DR. Prevalence and clinical significance of zidovudine resistance mutations in human immunodeficiency virus isolated from patients after long-term zidovudine treatment. AIDS Clinical Trials Group 116B/117 Study Team and the Virology Committee Resistance Working Group. J Infect Dis. 1995 May; 171(5):1172-9. PMID: 7538548.
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  57. Kimberlin DW, Crumpacker CS, Straus SE, Biron KK, Drew WL, Hayden FG, McKinlay M, Richman DD, Whitley RJ. Antiviral resistance in clinical practice. Antiviral Res. 1995 Apr; 26(4):423-38. PMID: 7574544.
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  58. Zhang LJ, Hanff P, Rutherford C, Churchill WH, Crumpacker CS. Detection of human cytomegalovirus DNA, RNA, and antibody in normal donor blood. J Infect Dis. 1995 Apr; 171(4):1002-6. PMID: 7706776.
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  59. D'Aquila RT, Johnson VA, Welles SL, Japour AJ, Kuritzkes DR, DeGruttola V, Reichelderfer PS, Coombs RW, Crumpacker CS, Kahn JO, Richman DD. Zidovudine resistance and HIV-1 disease progression during antiretroviral therapy. AIDS Clinical Trials Group Protocol 116B/117 Team and the Virology Committee Resistance Working Group. Ann Intern Med. 1995 Mar 15; 122(6):401-8. PMID: 7856987.
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  60. Lan Y, Japour AJ, Kim S, Welles SL, Crumpacker CS, Cooper E, Al-Attar I, McIntosh K. A rapid, direct test for zidovudine susceptibility in clinical isolates of human immunodeficiency virus type 1 (HIV-1) from infected children. Clin Diagn Virol. 1995 Mar; 3(3):259-71. PMID: 15566807.
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  61. von Reyn FC, Arbeit RD, Friedland GH, Crumpacker CS. Criteria for the diagnosis of infective endocarditis. Clin Infect Dis. 1994 Aug; 19(2):368-70. PMID: 7864961.
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  62. Fife KH, Crumpacker CS, Mertz GJ, Hill EL, Boone GS. Recurrence and resistance patterns of herpes simplex virus following cessation of > or = 6 years of chronic suppression with acyclovir. Acyclovir Study Group. J Infect Dis. 1994 Jun; 169(6):1338-41. PMID: 8195614.
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  63. Mayers DL, Japour AJ, Arduino JM, Hammer SM, Reichman R, Wagner KF, Chung R, Lane J, Crumpacker CS, McLeod GX, et al. Dideoxynucleoside resistance emerges with prolonged zidovudine monotherapy. The RV43 Study Group. Antimicrob Agents Chemother. 1994 Feb; 38(2):307-14. PMID: 8192457; PMCID: PMC284445.
  64. Hardy D, Spector S, Polsky B, Crumpacker C, van der Horst C, Holland G, Freeman W, Heinemann MH, Sharuk G, Klystra J, et al. Combination of ganciclovir and granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients. The ACTG 073 Team. Eur J Clin Microbiol Infect Dis. 1994; 13 Suppl 2:S34-40. PMID: 7875151.
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  65. Hammer S, Crumpacker C, D'Aquila R, Jackson B, Lathey J, Livnat D, Reichelderfer P. Use of virologic assays for detection of human immunodeficiency virus in clinical trials: recommendations of the AIDS Clinical Trials Group Virology Committee. J Clin Microbiol. 1993 Oct; 31(10):2557-64. PMID: 8253949; PMCID: PMC265936.
  66. Monahan SJ, Barlam TF, Crumpacker CS, Parris DS. Two regions of the herpes simplex virus type 1 UL42 protein are required for its functional interaction with the viral DNA polymerase. J Virol. 1993 Oct; 67(10):5922-31. PMID: 8396660; PMCID: PMC238012.
  67. Oyan AM, Dolter KE, Langeland N, Goins WF, Glorioso JC, Haarr L, Crumpacker CS. Resistance of herpes simplex virus type 2 to neomycin maps to the N-terminal portion of glycoprotein C. J Virol. 1993 May; 67(5):2434-41. PMID: 8386261; PMCID: PMC237561.
  68. Steinberg HN, Anderson J, Crumpacker CS, Chatis PA. HIV infection of the BS-1 human stroma cell line: effect on murine hematopoiesis. Virology. 1993 Mar; 193(1):524-7. PMID: 8438590.
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  69. Li CJ, Zhang LJ, Dezube BJ, Crumpacker CS, Pardee AB. Three inhibitors of type 1 human immunodeficiency virus long terminal repeat-directed gene expression and virus replication. Proc Natl Acad Sci U S A. 1993 Mar 01; 90(5):1839-42. PMID: 8446597; PMCID: PMC45975.
  70. Dieterich DT, Kotler DP, Busch DF, Crumpacker C, Du Mond C, Dearmand B, Buhles W. Ganciclovir treatment of cytomegalovirus colitis in AIDS: a randomized, double-blind, placebo-controlled multicenter study. J Infect Dis. 1993 Feb; 167(2):278-82. PMID: 8380610.
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  71. Zhang L, Waters C, Nichols J, Crumpacker C. Inhibition of HIV-1 RNA production by the diphtheria toxin-related IL-2 fusion proteins DAB486IL-2 and DAB389IL-2. J Acquir Immune Defic Syndr. 1992 Dec; 5(12):1181-7. PMID: 1453329.
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  72. Kahn JO, Lagakos SW, Richman DD, Cross A, Pettinelli C, Liou SH, Brown M, Volberding PA, Crumpacker CS, Beall G, et al. A controlled trial comparing continued zidovudine with didanosine in human immunodeficiency virus infection. The NIAID AIDS Clinical Trials Group. N Engl J Med. 1992 Aug 27; 327(9):581-7. PMID: 1353607.
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  73. Chatis PA, Crumpacker CS. Resistance of herpesviruses to antiviral drugs. Antimicrob Agents Chemother. 1992 Aug; 36(8):1589-95. PMID: 1416838; PMCID: PMC191999.
  74. Crumpacker CS. Mechanism of action of foscarnet against viral polymerases. Am J Med. 1992 Feb 14; 92(2A):3S-7S. PMID: 1371038.
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  75. Dezube BJ, Pardee AB, Beckett LA, Ahlers CM, Ecto L, Allen-Ryan J, Anisowicz A, Sager R, Crumpacker CS. Cytokine dysregulation in AIDS: in vivo overexpression of mRNA of tumor necrosis factor-alpha and its correlation with that of the inflammatory cytokine GRO. J Acquir Immune Defic Syndr. 1992; 5(11):1099-104. PMID: 1403638.
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  76. Safrin S, Crumpacker C, Chatis P, Davis R, Hafner R, Rush J, Kessler HA, Landry B, Mills J. A controlled trial comparing foscarnet with vidarabine for acyclovir-resistant mucocutaneous herpes simplex in the acquired immunodeficiency syndrome. The AIDS Clinical Trials Group. N Engl J Med. 1991 Aug 22; 325(8):551-5. PMID: 1649971.
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  77. Heagy W, Crumpacker C, Lopez PA, Finberg RW. Inhibition of immune functions by antiviral drugs. J Clin Invest. 1991 Jun; 87(6):1916-24. PMID: 1904068; PMCID: PMC296943.
  78. Japour AJ, Chatis PA, Eigenrauch HA, Crumpacker CS. Detection of human immunodeficiency virus type 1 clinical isolates with reduced sensitivity to zidovudine and dideoxyinosine by RNA.RNA hybridization. Proc Natl Acad Sci U S A. 1991 Apr 15; 88(8):3092-6. PMID: 1707532; PMCID: PMC51391.
  79. Steinberg HN, Crumpacker CS, Chatis PA. In vitro suppression of normal human bone marrow progenitor cells by human immunodeficiency virus. J Virol. 1991 Apr; 65(4):1765-9. PMID: 2002542; PMCID: PMC239983.
  80. Kaplowitz LG, Baker D, Gelb L, Blythe J, Hale R, Frost P, Crumpacker C, Rabinovich S, Peacock JE, Herndon J, et al. Prolonged continuous acyclovir treatment of normal adults with frequently recurring genital herpes simplex virus infection. The Acyclovir Study Group. JAMA. 1991 Feb 13; 265(6):747-51. PMID: 1990191.
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  81. Chatis PA, Crumpacker CS. Analysis of the thymidine kinase gene from clinically isolated acyclovir-resistant herpes simplex viruses. Virology. 1991 Feb; 180(2):793-7. PMID: 1846499.
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  82. Crumpacker CS, Heath-Chiozzi M. Overview of cytomegalovirus infections in HIV-infected patients: current therapies and future strategies. J Acquir Immune Defic Syndr. 1991; 4 Suppl 1:S1-5. PMID: 1848615.
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  83. Goodrich LD, Schaffer PA, Dorsky DI, Crumpacker CS, Parris DS. Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis. J Virol. 1990 Dec; 64(12):5738-49. PMID: 2173766; PMCID: PMC248718.
  84. Gulick RM, Heath-Chiozzi M, Crumpacker CS. Varicella-zoster virus disease in patients with human immunodeficiency virus infection. Arch Dermatol. 1990 Aug; 126(8):1086-8. PMID: 2200349.
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  85. Dorsky DI, Crumpacker CS. Site-specific mutagenesis of a highly conserved region of the herpes simplex virus type 1 DNA polymerase gene. J Virol. 1990 Mar; 64(3):1394-7. PMID: 2154619; PMCID: PMC249264.
  86. Gallo ML, Dorsky DI, Crumpacker CS, Parris DS. The essential 65-kilodalton DNA-binding protein of herpes simplex virus stimulates the virus-encoded DNA polymerase. J Virol. 1989 Dec; 63(12):5023-9. PMID: 2555539; PMCID: PMC251162.
  87. Heagy W, Strom TB, Kelley VE, Collela J, Crumpacker C, Williams JM, Shapiro HM, Laubenstein L, Finberg R. Recombinant human gamma interferon enhances in vitro activation of lymphocytes isolated from patients with acquired immunodeficiency syndrome. Infect Immun. 1989 Nov; 57(11):3619-28. PMID: 2572558; PMCID: PMC259876.
  88. Kishimoto C, Kurnick JT, Fallon JT, Crumpacker CS, Abelmann WH. Characteristics of lymphocytes cultured from murine viral myocarditis specimens: a preliminary and technical report. J Am Coll Cardiol. 1989 Sep; 14(3):799-802. PMID: 2768726.
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  89. Crumpacker CS. Molecular targets of antiviral therapy. N Engl J Med. 1989 Jul 20; 321(3):163-72. PMID: 2546077.
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  90. Bubley GJ, Chapman B, Chapman SK, Crumpacker CS, Schnipper LE. Effect of acyclovir on radiation- and chemotherapy-induced mouth lesions. Antimicrob Agents Chemother. 1989 Jun; 33(6):862-5. PMID: 2669626; PMCID: PMC284246.
  91. Chatis PA, Miller CH, Schrager LE, Crumpacker CS. Successful treatment with foscarnet of an acyclovir-resistant mucocutaneous infection with herpes simplex virus in a patient with acquired immunodeficiency syndrome. N Engl J Med. 1989 Feb 02; 320(5):297-300. PMID: 2536137.
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  92. Erlich KS, Mills J, Chatis P, Mertz GJ, Busch DF, Follansbee SE, Grant RM, Crumpacker CS. Acyclovir-resistant herpes simplex virus infections in patients with the acquired immunodeficiency syndrome. N Engl J Med. 1989 Feb 02; 320(5):293-6. PMID: 2536136.
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  93. Haffey ML, Stevens JT, Terry BJ, Dorsky DI, Crumpacker CS, Wietstock SM, Ruyechan WT, Field AK. Expression of herpes simplex virus type 1 DNA polymerase in Saccharomyces cerevisiae and detection of virus-specific enzyme activity in cell-free lysates. J Virol. 1988 Dec; 62(12):4493-8. PMID: 2846866; PMCID: PMC253559.
  94. Kishimoto C, Crumpacker CS, Abelmann WH. Ribavirin treatment of murine coxsackievirus B3 myocarditis with analyses of lymphocyte subsets. J Am Coll Cardiol. 1988 Nov; 12(5):1334-41. PMID: 2844874.
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  95. Kishimoto C, Crumpacker CS, Abelmann WH. Prevention of murine coxsackie B3 viral myocarditis and associated lymphoid organ atrophy with recombinant human leucocyte interferon alpha A/D. Cardiovasc Res. 1988 Oct; 22(10):732-8. PMID: 2855719.
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  96. Dorsky DI, Crumpacker CS. Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity. J Virol. 1988 Sep; 62(9):3224-32. PMID: 2841474; PMCID: PMC253441.
  97. Crumpacker C, Marlowe S, Zhang JL, Abrams S, Watkins P. Treatment of cytomegalovirus pneumonia. Rev Infect Dis. 1988 Jul-Aug; 10 Suppl 3:S538-46. PMID: 2847291.
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  98. Miklozek CL, Crumpacker CS, Royal HD, Come PC, Sullivan JL, Abelmann WH. Myocarditis presenting as acute myocardial infarction. Am Heart J. 1988 Apr; 115(4):768-76. PMID: 3354405.
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  99. Kishimoto C, Misaki T, Crumpacker CS, Abelmann WH. Serial immunologic identification of lymphocyte subsets in murine coxsackievirus B3 myocarditis: different kinetics and significance of lymphocyte subsets in the heart and in peripheral blood. Circulation. 1988 Mar; 77(3):645-53. PMID: 2830046.
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  100. Crumpacker CS. Treatment of opportunistic viral infections. AIDS. 1988; 2 Suppl 1:S191-3. PMID: 2852503.
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  101. Crumpacker CS. Significance of resistance of herpes simplex virus to acyclovir. J Am Acad Dermatol. 1988 Jan; 18(1 Pt 2):190-5. PMID: 2828441.
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  102. Hecht DW, Snydman DR, Crumpacker CS, Werner BG, Heinze-Lacey B. Ganciclovir for treatment of renal transplant-associated primary cytomegalovirus pneumonia. J Infect Dis. 1988 Jan; 157(1):187-90. PMID: 2826608.
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  103. Matsumori A, Crumpacker CS, Abelmann WH, Kawai C. Virus vaccine and passive immunization for the prevention of viral myocarditis in mice. Jpn Circ J. 1987 Dec; 51(12):1362-4. PMID: 2832629.
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  104. Dorsky DI, Crumpacker CS. Drugs five years later: acyclovir. Ann Intern Med. 1987 Dec; 107(6):859-74. PMID: 3318610.
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  105. Crumpacker C, Heagy W, Bubley G, Monroe JE, Finberg R, Hussey S, Schnipper L, Lucey D, Lee TH, McLane MF, et al. Ribavirin treatment of the acquired immunodeficiency syndrome (AIDS) and the acquired-immunodeficiency-syndrome-related complex (ARC). A phase 1 study shows transient clinical improvement associated with suppression of the human immunodeficiency virus and enhanced lymphocyte proliferation. Ann Intern Med. 1987 Nov; 107(5):664-74. PMID: 3662279.
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  106. Bubley GJ, Balzarini J, Crumpacker CS, de Clercq E, Schnipper LE. The effect of (E)-5-(2-bromovinyl)-2'-deoxyuridine on DNA repair and mutagenesis of herpes simplex virus type 1. Virology. 1987 Nov; 161(1):242-4. PMID: 2823464.
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  107. Surman OS, Crumpacker C. Psychological aspects of herpes simplex viral infection: report of six cases. Am J Clin Hypn. 1987 Oct; 30(2):125-31. PMID: 3687813.
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  108. Matsumori A, Crumpacker CS, Abelmann WH. Prevention of viral myocarditis with recombinant human leukocyte interferon alpha A/D in a murine model. J Am Coll Cardiol. 1987 Jun; 9(6):1320-5. PMID: 3034992.
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  109. Matsumori A, Kawai C, Crumpacker CS, Abelmann WH. Pathogenesis and preventive and therapeutic trials in an animal model of dilated cardiomyopathy induced by a virus. Jpn Circ J. 1987 Jun; 51(6):661-4. PMID: 2822976.
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  110. Dorsky D, Chatis P, Crumpacker C. Functional expression of a cloned herpes simplex virus type 1 DNA polymerase gene. J Virol. 1987 May; 61(5):1704-7. PMID: 3033298; PMCID: PMC254160.
  111. Vogt MW, Hartshorn KL, Furman PA, Chou TC, Fyfe JA, Coleman LA, Crumpacker C, Schooley RT, Hirsch MS. Ribavirin antagonizes the effect of azidothymidine on HIV replication. Science. 1987 Mar 13; 235(4794):1376-9. PMID: 2435003.
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  112. Craven DE, Awdeh ZL, Kunches LM, Yunis EJ, Dienstag JL, Werner BG, Polk BF, Syndman DR, Platt R, Crumpacker CS, et al. Nonresponsiveness to hepatitis B vaccine in health care workers. Results of revaccination and genetic typings. Ann Intern Med. 1986 Sep; 105(3):356-60. PMID: 2943202.
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  113. Crumpacker C, Bubley G, Lucey D, Hussey S, Connor J. Ribavirin enters cerebrospinal fluid. Lancet. 1986 Jul 05; 2(8497):45-6. PMID: 2873344.
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  114. Eidelberg D, Sotrel A, Vogel H, Walker P, Kleefield J, Crumpacker CS. Progressive polyradiculopathy in acquired immune deficiency syndrome. Neurology. 1986 Jul; 36(7):912-6. PMID: 3012412.
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  115. Monrad ES, Matsumori A, Murphy JC, Fox JG, Crumpacker CS, Abelmann WH. Therapy with cyclosporine in experimental murine myocarditis with encephalomyocarditis virus. Circulation. 1986 May; 73(5):1058-64. PMID: 3698228.
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  116. Bubley GJ, Crumpacker CS, Schnipper LE. Incorporation of 1-beta-D-arabinofuranosylcytosine into DNA and mutagenesis of herpes simplex virus type 1. Antimicrob Agents Chemother. 1986 Apr; 29(4):716-9. PMID: 3010854; PMCID: PMC180475.
  117. Liu LX, Seward SJ, Crumpacker CS. Intravenous trimethoprim-sulfamethoxazole and ataxia. Ann Intern Med. 1986 Mar; 104(3):448. PMID: 3484928.
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  118. Werner BG, Dienstag JL, Kuter BJ, Polk BF, Snydman DR, Craven DE, Crumpacker CS, Platt R, Grady GF. Isolated antibody to hepatitis B surface antigen and response to hepatitis B vaccination. Ann Intern Med. 1985 Aug; 103(2):201-5. PMID: 3160274.
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  119. Dienstag JL, Werner BG, McLane MF, Snydman DR, Grady GF, Craven DE, Crumpacker CS, Polk BF, Platt R, Allan J, et al. Absence of antibodies to HTLV-III in health workers after hepatitis B vaccination. JAMA. 1985 Aug 23-30; 254(8):1064-6. PMID: 2991619.
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  120. Oliver S, Bubley G, Crumpacker C. Inhibition of HSV-transformed murine cells by nucleoside analogs, 2'-NDG and 2'-nor-cGMP: mechanisms of inhibition and reversal by exogenous nucleosides. Virology. 1985 Aug; 145(1):84-93. PMID: 2990104.
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  121. Tolman RL, Field AK, Karkas JD, Wagner AF, Germershausen J, Crumpacker C, Scolnick EM. 2'-Nor-cGMP: a seco-cyclic nucleotide with powerful anti-DNA-viral activity. Biochem Biophys Res Commun. 1985 May 16; 128(3):1329-35. PMID: 2988534.
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  122. Matsumori A, Wang H, Abelmann WH, Crumpacker CS. Treatment of viral myocarditis with ribavirin in an animal preparation. Circulation. 1985 Apr; 71(4):834-9. PMID: 2982522.
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  123. Snydman DR, Muñoz A, Werner BG, Polk BF, Craven DE, Platt R, Crumpacker C, Ouellet-Hellstrom R, Nash B, Grady GF, et al. A multivariate analysis of risk factors for hepatitis B virus infection among hospital employees screened for vaccination. Am J Epidemiol. 1984 Nov; 120(5):684-93. PMID: 6496449.
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  124. Dienstag JL, Werner BG, Polk BF, Snydman DR, Craven DE, Platt R, Crumpacker CS, Ouellet-Hellstrom R, Grady GF. Hepatitis B vaccine in health care personnel: safety, immunogenicity, and indicators of efficacy. Ann Intern Med. 1984 Jul; 101(1):34-40. PMID: 6233921.
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  125. Friedland G, von Reyn CF, Levy B, Arbeit R, Dasse P, Crumpacker C. Nosocomial endocarditis. Infect Control. 1984 Jun; 5(6):284-8. PMID: 6564081.
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  126. Bubley GJ, Crumpacker CS, Schnipper LE. Repair of DNA following incorporation of 1-beta-D-arabinofuranosylcytosine into herpes simplex virus type 1. Cancer Res. 1984 May; 44(5):1813-8. PMID: 6324990.
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  127. Spruance SL, Crumpacker CS, Schnipper LE, Kern ER, Marlowe S, Arndt KA, Overall JC. Early, patient-initiated treatment of herpes labialis with topical 10% acyclovir. Antimicrob Agents Chemother. 1984 May; 25(5):553-5. PMID: 6732224; PMCID: PMC185583.
  128. Crumpacker CS, Kowalsky PN, Oliver SA, Schnipper LE, Field AK. Resistance of herpes simplex virus to 9-[[2-hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine: physical mapping of drug synergism within the viral DNA polymerase locus. Proc Natl Acad Sci U S A. 1984 Mar; 81(5):1556-60. PMID: 6324203; PMCID: PMC344876.
  129. Tocci MJ, Livelli TJ, Perry HC, Crumpacker CS, Field AK. Effects of the nucleoside analog 2'-nor-2'-deoxyguanosine on human cytomegalovirus replication. Antimicrob Agents Chemother. 1984 Feb; 25(2):247-52. PMID: 6324669; PMCID: PMC185483.
  130. Schnipper LE, Levin M, Crumpacker CS, Gilchrest BA. Virus replication and induction of interferon in human epidermal keratinocytes following infection with herpes simplex virus. J Invest Dermatol. 1984 Jan; 82(1):94-6. PMID: 6197494.
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  131. Kufe D, Herrick D, Crumpacker C, Schnipper L. Incorporation of 1-beta-D-arabinofuranosylcytosine into DNA from herpes simplex virus resistant to 9-beta-D-arabinofuranosyladenine. Cancer Res. 1984 Jan; 44(1):69-73. PMID: 6317173.
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  132. Crumpacker C. Resistance of herpes simplex virus to antiviral agents. Is it clinically important? Drugs. 1983 Nov; 26(5):373-7. PMID: 6315331.
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  133. Bubley G, Crumpacker C, De Clercq E, Schnipper L. Effects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on the proliferation of herpes simplex virus type 1-transformed and thymidine kinase-deficient mouse cells. Virology. 1983 Sep; 129(2):490-2. PMID: 6312685.
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  134. Schnipper LE, Lewin AA, Crumpacker CS. Enhanced survival of ultraviolet-irradiated herpes simplex virus in cells exposed to antiviral agents. Mutat Res. 1983 Feb; 116(2):65-72. PMID: 6298618.
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  135. Rose RM, Crumpacker C, Waner JL, Brain JD. Treatment of murine cytomegalovirus pneumonia with acyclovir and interferon. Am Rev Respir Dis. 1983 Feb; 127(2):198-203. PMID: 6187251.
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  136. Crumpacker CS. The Paul-Bunnel test revisited. Rev Infect Dis. 1982 Sep-Oct; 4(5):1069-70. PMID: 6293035.
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  137. Crumpacker CS, Schnipper LE, Kowalsky PN, Sherman DM. Resistance of herpes simplex virus to adenine arabinoside and E-5-(2-bromovinyl)-2'-deoxyuridine: a physical analysis. J Infect Dis. 1982 Aug; 146(2):167-72. PMID: 6286786.
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  138. Crumpacker CS, Schnipper LE, Chartrand P, Knopf KW. Genetic mechanisms of resistance to acyclovir in herpes simplex virus. Am J Med. 1982 Jul 20; 73(1A):361-8. PMID: 6285723.
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  139. Spruance SL, Crumpacker CS. Topical 5 percent acyclovir in polyethylene glycol for herpes simplex labialis. Antiviral effect without clinical benefit. Am J Med. 1982 Jul 20; 73(1A):315-9. PMID: 6285721.
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  140. Schnipper LE, Crumpacker CS, Marlowe SI, Kowalsky P, Hershey BJ, Levin MJ. Drug-resistant herpes simplex virus in vitro and after acyclovir treatment in an immunocompromised patient. Am J Med. 1982 Jul 20; 73(1A):387-92. PMID: 6285729.
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  141. Spruance SL, Schnipper LE, Overall JC, Kern ER, Wester B, Modlin J, Wenerstrom G, Burton C, Arndt KA, Chiu GL, Crumpacker CS. Treatment of herpes simplex labialis with topical acyclovir in polyethylene glycol. J Infect Dis. 1982 Jul; 146(1):85-90. PMID: 7045255.
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  142. Modlin JF, Crumpacker CS. Coxsackievirus B infection in pregnant mice and transplacental infection of the fetus. Infect Immun. 1982 Jul; 37(1):222-6. PMID: 6286490; PMCID: PMC347516.
  143. Rose RM, Crumpacker C, Waner JL, Brain JD. Murine cytomegalovirus pneumonia. Description of a model and investigation of pathogenesis. Am Rev Respir Dis. 1982 May; 125(5):568-73. PMID: 6282153.
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  144. Crumpacker CS, Schnipper LE, Marlowe SI, Kowalsky PN, Hershey BJ, Levin MJ. Resistance to antiviral drugs of herpes simplex virus isolated from a patient treated with acyclovir. N Engl J Med. 1982 Feb 11; 306(6):343-6. PMID: 6275267.
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  145. Knopf KW, Kaufman ER, Crumpacker C. Physical mapping of drug resistance mutations defines an active center of the herpes simplex virus DNA polymerase enzyme. J Virol. 1981 Sep; 39(3):746-57. PMID: 6270349; PMCID: PMC171308.
  146. Davidson RL, Kaufman ER, Crumpacker CS, Schnipper LE. Inhibition of herpes simplex virus transformed and nontransformed cells by acycloguanosine: mechanisms of uptake and toxicity. Virology. 1981 Aug; 113(1):9-19. PMID: 6267792.
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  147. Von Reyn CF, Levy BS, Arbeit RD, Friedland G, Crumpacker CS. Infective endocarditis: an analysis based on strict case definitions. Ann Intern Med. 1981 Apr; 94(4 pt 1):505-18. PMID: 7011141.
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  148. Crumpacker CS, Chartrand P, Subak-Sharpe JH, Wilkie NM. Resistance of herpes simplex virus to acycloguanosine--genetic and physical analysis. Virology. 1980 Aug; 105(1):171-84. PMID: 6251603.
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  149. Chartrand P, Crumpacker CS, Schaffer PA, Wilkie NM. Physical and genetic analysis of the herpes simplex virus DNA polymerase locus. Virology. 1980 Jun; 103(2):311-26. PMID: 6247818.
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  150. Schnipper LE, Crumpacker CS. Resistance of herpes simplex virus to acycloguanosine: role of viral thymidine kinase and DNA polymerase loci. Proc Natl Acad Sci U S A. 1980 Apr; 77(4):2270-3. PMID: 6246532; PMCID: PMC348695.
  151. Schnipper LE, Lewin AA, Swartz M, Crumpacker CS. Mechanisms of photodynamic inactivation of herpes simplex viruses: comparison between methylene blue, light plus electricity, and hematoporhyrin plus light. J Clin Invest. 1980 Feb; 65(2):432-8. PMID: 6243310; PMCID: PMC371381.
  152. Lewin AA, Schnipper LE, Crumpacker CS. Photodynamic inactivation of herpes simplex virus by hematoporphyrin derivative and light. Proc Soc Exp Biol Med. 1980 Jan; 163(1):81-90. PMID: 6243414.
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  153. Crumpacker CS. Viral glycoproteins in infectious disease processes. Rev Infect Dis. 1980 Jan-Feb; 2(1):78-103. PMID: 6994204.
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  154. Swartz MR, Schnipper LE, Lewin AA, Crumpacker CS. Inactivation of herpes simplex virus with methylene blue, light, and electricity. Proc Soc Exp Biol Med. 1979 Jun; 161(2):204-9. PMID: 221933.
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  155. Spruance SL, Crumpacker CS, Haines H, Bader C, Mehr K, MacCalman J, Schnipper LE, Klauber MR, Overall JC. Ineffectiveness of topical adenine arabinoside 5'-monophosphate in the treatment of recurrent herpes simplex labialis. N Engl J Med. 1979 May 24; 300(21):1180-4. PMID: 86158.
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  156. Crumpacker CS, Schnipper LE, Zaia JA, Levin MJ. Growth inhibition by acycloguanosine of herpesviruses isolated from human infections. Antimicrob Agents Chemother. 1979 May; 15(5):642-5. PMID: 230783; PMCID: PMC352730.
  157. Bader C, Crumpacker CS, Schnipper LE, Ransil B, Clark JE, Arndt K, Freedberg IM. The natural history of recurrent facial-oral infection with herpes simplex virus. J Infect Dis. 1978 Dec; 138(6):897-905. PMID: 216753.
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  158. Lewis AM, Levine AS, Crumpacker CS, Levin MJ, Samaha RJ, Henry PH. Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. V. Isolation of additional hybrids which differ in their simian virus 40-specific biological properties. J Virol. 1973 May; 11(5):655-64. PMID: 4350710; PMCID: PMC355161.
  159. Henry PH, Schnipper LE, Samaha RJ, Crumpacker CS, Lewis AM, Levine AS. Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. VI. Characterization of the DNA from five nondefective hybrid viruses. J Virol. 1973 May; 11(5):665-71. PMID: 4350711; PMCID: PMC355162.
  160. Oxman MN, Levine AS, Crumpacker CS, Levin MJ, Henry PH, Lewis AM. Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. IV. Characterization of the simian virus 40 ribonucleic acid species induced by wild-type simian virus 40 and by the nondefective hybrid virus, Ad2 + ND 1 . J Virol. 1971 Aug; 8(2):215-24. PMID: 4329969; PMCID: PMC356233.
  161. Onion DK, Crumpacker CS, Gilliland BC. Arthritis of hepatitis associated with Australia antigen. Ann Intern Med. 1971 Jul; 75(1):29-33. PMID: 5091564.
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  162. Levin MJ, Crumpacker CS, Lewis AM, Oxman MN, Henry PH, Rowe WP. Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. II. Relationship of adenovirus 2 deoxyribonucleic acid and simian virus 40 deoxyribonucleic acid in the Ad2+ND genome. J Virol. 1971 Mar; 7(3):343-51. PMID: 4323709; PMCID: PMC356124.
  163. Crumpacker CS, Henry PH, Kakefuda T, Rowe WP, Levin MJ, Lewis AM. Studies of nondefective adenovirus 2-simian virus 40 hybrid viruses. 3. Base composition, molecular weight, and conformation of the Ad2+ND genome. J Virol. 1971 Mar; 7(3):352-8. PMID: 4323710; PMCID: PMC356125.
  164. Crumpacker CS, Levin MJ, Wiese WH, Rowe WP, Lewis AM. Adenovirus type 2-simian virus 40 hybrid population: evidence for a hybrid deoxyribonucleic acid molecule and the absence of adenovirus-encapsidated circular simian virus 40 deoxyribonucleic acid. J Virol. 1970 Dec; 6(6):788-94. PMID: 4322081; PMCID: PMC376196.
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