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profileJohn R. Knight, M.D.

TitleAssociate Professor of Pediatrics
InstitutionBoston Children's Hospital
DepartmentPediatrics
AddressChildrens Hospital
Pediatrics
300 Longwood Ave
Boston MA 02115
Phone617/355-5433
Fax617/730-0049
vCardDownload vCard (login for email)

Collapse Biography 
Collapse awards and honors
1972Magna Cum Laude
1998Best Scientific Abstract
1999 - 2002Research Scholar Program
1998Herman Cone Lecture
2000Marilyn Haynie Award for Excellence in Mentoring
2002Best Scientific Abstract
2002Excellence in Mentorship
2004 - 2009K07 Academic Career Award
2006Best Scientific Abstract
2008Endowed Chair in Developmental Medicine
2011Distinguished Academic Career
2009 - 2010Best Scientific Abstract

Collapse Overview 
Collapse overview
Research, Teaching, and Clinical Contributions:
Narrative: After completing my fellowship in general pediatrics in 1992, I spent the first five years of my academic career concentrating on clinical and educational activities. During the last ten years, I have transitioned to spending most of my professional time on clinical research. Education: In 1993 I developed the Behavioral Pediatrics block rotation for pediatric residents at Children’s Hospital. In 1996, I was awarded grant funding from the Maternal and Child Health Bureau (MCHB) for the Collaborative Office Rounds project, aimed at providing problem-based education in psychosocial problems for community pediatricians. As PI, I have now seen this grant through four competing renewals over ten years. I then collaborated with Dr. Jean Emans from the Division of Adolescent/Young Adult Medicine to produce a standardized national curriculum for pediatric residents in child growth, development, behavior, and adolescent health. We enlisted fellows and junior faculty as case writers. I was the PI of two grants that supported this work, Co-PI of a third, and Dr. Emans and I served as national project Co-Directors. The completed curriculum was published in a three-volume book series, which MCHB distributed to every pediatric and family medicine residency training program in the U.S. I directed construction of the project’s website (www.pedicases.org), from which more than 24,000 educational sections (i.e., chapters) have been downloaded by more than 5,000 registered faculty so far. At Harvard Medical School, I oversaw development of the Addictions Theme and in 1997I became the Associate Director for Medical Education at the Division on Addictions. In 1999 I became Director of the HMS Addiction Medicine CME course, which has doubled in size under my leadership. I have given more than 100 invited presentations and 18 peer-review workshops at national meetings, many involving fellows and junior faculty members whom I mentor. I served for two years as the Director of Fellowship Training for the Division of General Pediatrics. I have received two mentorship awards and was selected as one of 11 national mentors for the Health Resources and Services Administration (HRSA)-supported faculty development project in substance abuse education.
Research: The primary goal of my research is to improve screening and intervention for adolescent substance abuse in general medical settings. My first studies in this area assessed the reliability of existing screening instruments among adolescent medical patients. I next conducted a pilot study aimed at developing a new screening device, the CRAFFT test, which was developmentally appropriate for adolescents, accurate, and practical for use in busy medical settings. In 1999 I was awarded an R01 grant from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) to conduct a validation study of the CRAFFT in a larger, general adolescent clinic population. This study has led to five publications (p. 18-19; #15-18, #20) and, as a result of this research, the CRAFFT has become the recommended standard of care screen for substance abuse among adolescent patients. CRAFFT has been reprinted in American Academy of Pediatrics (AAP) policy statements, the AAP Substance Abuse Guide, the Bright Futures Mental Health Guide, and in other national reports and guidebooks. We have distributed more than 20,000 CRAFFT test pocket cards in response to requests from individuals and health care organizations from across the U.S, Canada, and the U.K; and given permission for translations of the CRAFFT into French (Swiss Ministry of Health), Spanish, Finnish, Turkish, Czech, Russian, and Japanese. The next phase of my research is aimed at implementation of CRAFFT screening, and at development and testing of office-based interventions. I directed a pilot study, funded by the Robert Wood Johnson Foundation (RWJF), of a brief behavioral counseling approach for substance abuse that can be widely applied in primary care settings and a larger RWJF-funded multi-site trial of implementation of CRAFFT test screening. In 2004 I received two R01 grants from the National Institute on Drug Abuse (NIDA) to conduct (1) a randomized controlled trial of our new therapeutic approach and (2) an efficacy trial of screening and brief physician advice. In 2006 I received a 3rd R01 from NIDA through the competing supplement mechanism for an international collaboration with investigators in the Czech Republic in drug abuse research.
Leadership: In 1999 I founded the Center for Adolescent Substance Abuse Research (CeASAR) at Children’s Hospital Boston. CeASAR is a national research center that supports a full-time Director of Data Management (Sherritt), Director of Research Operations (Van Hook), Clinical Coordinator (Germak), Education Specialist (Silverman), and 1-4 Study Coordinators and Research Assistants. Part-time staff includes a PhD-level epidemiologist (Harris) and several junior faculty members (Wilson, Levy, O’Sullivan, Rojas). I currently serve as full-time Director of CeASAR. In 2002 I founded a primary care research network, the New England Partnership for Substance Abuse Research (NEPSAR), which is centered at CeASAR and includes the Adolescent Clinic at Tufts-New England Medical Center, the Pediatric Departments at Cambridge Hospital and Fallon Clinic (Worcester, MA), the Vermont Child Health Improvement Project, the Concord Family Practice (Concord, NH) and a number of school-based health centers. NEPSAR serves as the foundation for our controlled trial of screening and physician brief advice. I have also served as PI of several studies of college student drinking, and as Co-PI of several other funded studies with those I mentor. During the past seven years, I have received grant funding totalling more than $6 million and published more than 40 original scientific articles (18 first author, 21 last), 17 clinical reviews and book chapters (10 first, 7 last), and 10 chapters for the national Bright Futures Curriculum. I completed my third term on the AAP Committee on Substance Abuse and I also completed a term on the Executive Board of the Association for Medical Education and Research in Substance Abuse. I have also served on six federal work groups (National Institute on Drug Abuse (3), NIAAA, President’s Office of National Drug Control Policy), and two federal grant review panels (Agency for Healthcare Research and Quality, NIAAA). In recognition of my leadership potential in alcohol research, in 2004 I received a K07 Academic Career Award from NIAAA.


Collapse Research 
Collapse research activities and funding
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
R34AA023026     (HARRIS, SION KIM)Sep 1, 2014 - Aug 31, 2017
NIH/NIAAA
Computer adaptation of screening, brief MET intervention to reduce teen drinking
Role: Co-Principal Investigator

R01AA021904     (HARRIS, SION KIM)Sep 15, 2013 - May 31, 2017
NIH/NIAAA
Computerized alcohol screening for children and adolescents (cASCA) in primary ca
Role: Co-Principal Investigator

RC1DE020699     (KNIGHT, JOHN R)Sep 22, 2009 - Aug 31, 2012
NIH/NIDCR
Dental and medical office iMET to reduce teen tobacco, alcohol, and drug use
Role: Principal Investigator

R01DA018848     (KNIGHT, JOHN R)Sep 30, 2004 - Aug 31, 2010
NIH/NIDA
Screening and Brief Advice to Reduce Teen Substance Use
Role: Principal Investigator

R01DA014553     (KNIGHT, JOHN R)Jun 1, 2004 - Mar 31, 2010
NIH/NIDA
Medical Office Intervention for Adolescent Drug Use
Role: Principal Investigator

Collapse Bibliographic 
Collapse selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
List All   |   Timeline
  1. Welsh JW, Knight JR, Hadland SE. Adolescent Frequent Heavy Drinking From 1991-2015. Pediatrics. 2017 Jun; 139(6). PMID: 28562297.
    View in: PubMed
  2. Welsh JW, Knight JR, Hou SS, Malowney M, Schram P, Sherritt L, Boyd JW. Association Between Substance Use Diagnoses and Psychiatric Disorders in an Adolescent and Young Adult Clinic-Based Population. J Adolesc Health. 2017 Jun; 60(6):648-652. PMID: 28202303.
    View in: PubMed
  3. Hadland SE, Knight JR, Harris SK. The Knowledge Gaps for Medical Marijuana in Pediatric Conditions. J Dev Behav Pediatr. 2015 Nov-Dec; 36(9):767-8. PMID: 26535886; PMCID: PMC4648553 [Available on 11/01/16].
  4. Hadland SE, Knight JR. Brief Interventions for Alcohol Use: Where, When, and How? Pediatrics. 2015 Oct; 136(4):e1002-4. PMID: 26347439; PMCID: PMC4586734 [Available on 10/01/16].
  5. Zaman T, Malowney M, Knight J, Boyd JW. Co-Occurrence of Substance-Related and Other Mental Health Disorders Among Adolescent Cannabis Users. J Addict Med. 2015 Jul-Aug; 9(4):317-21. PMID: 26083957.
    View in: PubMed
  6. Harris SK, Knight JR, Van Hook S, Sherritt L, Brooks TL, Kulig JW, Nordt CA, Saitz R. Adolescent substance use screening in primary care: Validity of computer self-administered versus clinician-administered screening. Subst Abus. 2016; 37(1):197-203. PMID: 25774878; PMCID: PMC4573375 [Available on 01/01/17].
  7. Hadland SE, Knight JR, Harris SK. Medical marijuana: review of the science and implications for developmental-behavioral pediatric practice. J Dev Behav Pediatr. 2015 Feb-Mar; 36(2):115-23. PMID: 25650954; PMCID: PMC4318349.
  8. Lange JN, Mufarrij PW, Easter L, Knight J, Holmes RP, Assimos DG. Fish oil supplementation and urinary oxalate excretion in normal subjects on a low-oxalate diet. Urology. 2014 Oct; 84(4):779-81. PMID: 25102784; PMCID: PMC4243483.
  9. Harris SK, Louis-Jacques J, Knight JR. Screening and brief intervention for alcohol and other abuse. Adolesc Med State Art Rev. 2014 Apr; 25(1):126-56. PMID: 25022191.
    View in: PubMed
  10. Pugatch M, Knight JR, McGuiness P, Sherritt L, Levy S. A group therapy program for opioid-dependent adolescents and their parents. Subst Abus. 2014; 35(4):435-41. PMID: 25174347.
    View in: PubMed
  11. Harris SK, Knight JR. Putting the Screen in Screening: Technology-Based Alcohol Screening and Brief Interventions in Medical Settings. Alcohol Res. 2014; 36(1):63-79. PMID: 26259001; PMCID: PMC4432859.
  12. Louis-Jacques J, Knight JR, Sherritt L, Van Hook S, Harris SK. Do risky friends change the efficacy of a primary care brief intervention for adolescent alcohol use? J Adolesc Health. 2014 Apr; 54(4):449-53. PMID: 24216313; PMCID: PMC3965615.
  13. Lange JN, Easter L, Amoroso R, Benfield D, Mufarri PW, Knight J, Holmes RP, Assimos DG. Internet program for facilitating dietary modifications limiting kidney stone risk. Can J Urol. 2013 Oct; 20(5):6922-6. PMID: 24128830.
    View in: PubMed
  14. Mufarrij PW, Lange JN, Knight J, Assimos DG, Holmes RP. The effects of Oxazyme on oxalate degradation: results and implications of in vitro experiments. J Endourol. 2013 Mar; 27(3):284-7. PMID: 22966963.
    View in: PubMed
  15. Boyd JW, Knight JR. Ethical and managerial considerations regarding state physician health programs. J Addict Med. 2012 Dec; 6(4):243-6. PMID: 23070127.
    View in: PubMed
  16. Riedel TJ, Knight J, Murray MS, Milliner DS, Holmes RP, Lowther WT. 4-Hydroxy-2-oxoglutarate aldolase inactivity in primary hyperoxaluria type 3 and glyoxylate reductase inhibition. Biochim Biophys Acta. 2012 Oct; 1822(10):1544-52. PMID: 22771891; PMCID: PMC3418427.
  17. Lange JN, Wood KD, Wong H, Otto R, Mufarrij PW, Knight J, Akpinar H, Holmes RP, Assimos DG. Sensitivity of human strains of Oxalobacter formigenes to commonly prescribed antibiotics. Urology. 2012 Jun; 79(6):1286-9. PMID: 22656407; PMCID: PMC3569510.
  18. Harris SK, Csémy L, Sherritt L, Starostova O, Van Hook S, Johnson J, Boulter S, Brooks T, Carey P, Kossack R, Kulig JW, Van Vranken N, Knight JR. Computer-facilitated substance use screening and brief advice for teens in primary care: an international trial. Pediatrics. 2012 Jun; 129(6):1072-82. PMID: 22566420; PMCID: PMC3362902.
  19. Lange JN, Wood KD, Knight J, Assimos DG, Holmes RP. Glyoxal formation and its role in endogenous oxalate synthesis. Adv Urol. 2012; 2012:819202. PMID: 22567004; PMCID: PMC3332067.
  20. Lange JN, Wood KD, Mufarrij PW, Callahan MF, Easter L, Knight J, Holmes RP, Assimos DG. The impact of dietary calcium and oxalate ratios on stone risk. Urology. 2012 Jun; 79(6):1226-9. PMID: 22480460.
    View in: PubMed
  21. Jiang J, Johnson LC, Knight J, Callahan MF, Riedel TJ, Holmes RP, Lowther WT. Metabolism of [13C5]hydroxyproline in vitro and in vivo: implications for primary hyperoxaluria. Am J Physiol Gastrointest Liver Physiol. 2012 Mar 15; 302(6):G637-43. PMID: 22207577; PMCID: PMC3311310.
  22. Knight J, Holmes RP, Cramer SD, Takayama T, Salido E. Hydroxyproline metabolism in mouse models of primary hyperoxaluria. Am J Physiol Renal Physiol. 2012 Mar 15; 302(6):F688-93. PMID: 22189945; PMCID: PMC3311317.
  23. Knight J, Hinsdale M, Holmes R. Glycolate and 2-phosphoglycolate content of tissues measured by ion chromatography coupled to mass spectrometry. Anal Biochem. 2012 Feb 01; 421(1):121-4. PMID: 22093610; PMCID: PMC3259265.
  24. Riedel TJ, Johnson LC, Knight J, Hantgan RR, Holmes RP, Lowther WT. Structural and biochemical studies of human 4-hydroxy-2-oxoglutarate aldolase: implications for hydroxyproline metabolism in primary hyperoxaluria. PLoS One. 2011; 6(10):e26021. PMID: 21998747; PMCID: PMC3188589.
  25. Knight J, Jiang J, Wood KD, Holmes RP, Assimos DG. Oxalate and sucralose absorption in idiopathic calcium oxalate stone formers. Urology. 2011 Aug; 78(2):475.e9-475.e13. PMID: 21676449; PMCID: PMC3152675.
  26. Jiang J, Knight J, Easter LH, Neiberg R, Holmes RP, Assimos DG. Impact of dietary calcium and oxalate, and Oxalobacter formigenes colonization on urinary oxalate excretion. J Urol. 2011 Jul; 186(1):135-9. PMID: 21575973; PMCID: PMC3143112.
  27. Levy S, Knight JR, Moore T, Weinstein Z, Sherritt L, Weiss RD. Acceptability of drug testing in an outpatient substance abuse program for adolescents. J Adolesc Health. 2011 Mar; 48(3):229-33. PMID: 21338892; PMCID: PMC3052946.
  28. Knight J, Assimos DG, Callahan MF, Holmes RP. Metabolism of primed, constant infusions of [1,2-¹³C2] glycine and [1-¹³C1] phenylalanine to urinary oxalate. Metabolism. 2011 Jul; 60(7):950-6. PMID: 21036374; PMCID: PMC3116940.
  29. Harris SK, Sherritt L, Van Hook S, Wechsler H, Knight JR. Alcohol policy enforcement and changes in student drinking rates in a statewide public college system: a follow-up study. Subst Abuse Treat Prev Policy. 2010 Aug 04; 5:18. PMID: 20684777; PMCID: PMC2924849.
  30. Hassan A, Csemy L, Rappo MA, Knight JR. Adolescent substance abuse around the world: an international perspective. Adolesc Med State Art Rev. 2009 Dec; 20(3):915-29, ix. PMID: 20653209.
    View in: PubMed
  31. Hassan A, Harris SK, Sherritt L, Van Hook S, Brooks T, Carey P, Kossack R, Kulig J, Knight JR. Primary care follow-up plans for adolescents with substance use problems. Pediatrics. 2009 Jul; 124(1):144-50. PMID: 19564294; PMCID: PMC4103426.
  32. Levy S, Sherritt L, Gabrielli J, Shrier LA, Knight JR. Screening adolescents for substance use-related high-risk sexual behaviors. J Adolesc Health. 2009 Nov; 45(5):473-7. PMID: 19837353; PMCID: PMC2813707.
  33. Sanchez-Samper X, Knight JR. Drug abuse by adolescents: general considerations. Pediatr Rev. 2009 Mar; 30(3):83-92; quiz 93. PMID: 19255122.
    View in: PubMed
  34. Passman CM, Holmes RP, Knight J, Easter L, Pais V, Assimos DG. Effect of soda consumption on urinary stone risk parameters. J Endourol. 2009 Mar; 23(3):347-50. PMID: 19275488; PMCID: PMC2827252.
  35. Knight J, Easter LH, Neiberg R, Assimos DG, Holmes RP. Increased protein intake on controlled oxalate diets does not increase urinary oxalate excretion. Urol Res. 2009 Apr; 37(2):63-8. PMID: 19183980; PMCID: PMC2683385.
  36. Harris SK, Sherritt LR, Holder DW, Kulig J, Shrier LA, Knight JR. Reliability and validity of the brief multidimensional measure of religiousness/spirituality among adolescents. J Relig Health. 2008 Dec; 47(4):438-57. PMID: 19093673.
    View in: PubMed
  37. Wilson CR, Harris SK, Sherritt L, Lawrence N, Glotzer D, Shaw JS, Knight JR. Parental alcohol screening in pediatric practices. Pediatrics. 2008 Nov; 122(5):e1022-9. PMID: 18977952.
    View in: PubMed
  38. Mentzer RM, Bartels C, Bolli R, Boyce S, Buckberg GD, Chaitman B, Haverich A, Knight J, Menasché P, Myers ML, Nicolau J, Simoons M, Thulin L, Weisel RD. Sodium-hydrogen exchange inhibition by cariporide to reduce the risk of ischemic cardiac events in patients undergoing coronary artery bypass grafting: results of the EXPEDITION study. Ann Thorac Surg. 2008 Apr; 85(4):1261-70. PMID: 18355507.
    View in: PubMed
  39. Levy S, Knight JR. Screening, brief intervention, and referral to treatment for adolescents. J Addict Med. 2008; 2(4):215-21. PMID: 21768991.
    View in: PubMed
  40. Levy S, Williams JF, Knight JR. Screening, brief intervention, and referral to treatment for adolescents: companion clinical case. J Addict Med. 2008; 2(4):222-6. PMID: 21768992.
    View in: PubMed
  41. Mears CJ, Knight JR. The role of schools in combating illicit substance abuse. Pediatrics. 2007 Dec; 120(6):1379-84. PMID: 18055689.
    View in: PubMed
  42. Rojas NL, Sherrit L, Harris S, Knight JR. The role of parental consent in adolescent substance use research. J Adolesc Health. 2008 Feb; 42(2):192-7. PMID: 18207098.
    View in: PubMed
  43. Knight JR, Harris SK, Sherritt L, Van Hook S, Lawrence N, Brooks T, Carey P, Kossack R, Kulig J. Prevalence of positive substance abuse screen results among adolescent primary care patients. Arch Pediatr Adolesc Med. 2007 Nov; 161(11):1035-41. PMID: 17984404.
    View in: PubMed
  44. Knight JR, Levy S. The national debate on drug testing in schools. J Adolesc Health. 2007 Nov; 41(5):419-20. PMID: 17950160.
    View in: PubMed
  45. Prokopovich S, Knight J, Assimos DG, Holmes RP. Variability of Oxalobacter formigenes and oxalate in stool samples. J Urol. 2007 Nov; 178(5):2186-90. PMID: 17870112; PMCID: PMC2637797.
  46. Knight J, Holmes RP, Assimos DG. Intestinal and renal handling of oxalate loads in normal individuals and stone formers. Urol Res. 2007 Jun; 35(3):111-7. PMID: 17431604; PMCID: PMC2637801.
  47. Knight JR, Hugenberger GP. On forgiveness. South Med J. 2007 Apr; 100(4):420-1. PMID: 17458413.
    View in: PubMed
  48. Knight JR, Sherritt L, Harris SK, Holder DW, Kulig J, Shrier LA, Gabrielli J, Chang G. Alcohol use and religiousness/spirituality among adolescents. South Med J. 2007 Apr; 100(4):349-55. PMID: 17458392; PMCID: PMC4143181.
  49. Levy S, Sherritt L, Vaughan BL, Germak M, Knight JR. Results of random drug testing in an adolescent substance abuse program. Pediatrics. 2007 Apr; 119(4):e843-8. PMID: 17403828.
    View in: PubMed
  50. Levy S, Vaughan BL, Angulo M, Knight JR. Buprenorphine replacement therapy for adolescents with opioid dependence: early experience from a children's hospital-based outpatient treatment program. J Adolesc Health. 2007 May; 40(5):477-82. PMID: 17448411.
    View in: PubMed
  51. Knight JR, Mears CJ. Testing for drugs of abuse in children and adolescents: addendum--testing in schools and at home. Pediatrics. 2007 Mar; 119(3):627-30. PMID: 17332219.
    View in: PubMed
  52. Van Hook S, Harris SK, Brooks T, Carey P, Kossack R, Kulig J, Knight JR. The "Six T's": barriers to screening teens for substance abuse in primary care. J Adolesc Health. 2007 May; 40(5):456-61. PMID: 17448404.
    View in: PubMed
  53. Knight JR, Harris SK, Sherritt L, Van Hook S, Lawrence N, Brooks T, Carey P, Kossack R, Kulig J. Adolescents' preference for substance abuse screening in primary care practice. Subst Abus. 2007; 28(4):107-17. PMID: 18077307.
    View in: PubMed
  54. Knight JR, Sanchez LT, Sherritt L, Bresnahan LR, Fromson JA. Outcomes of a monitoring program for physicians with mental and behavioral health problems. J Psychiatr Pract. 2007 Jan; 13(1):25-32. PMID: 17242589.
    View in: PubMed
  55. Hertz JA, Knight JR. Prescription drug misuse: a growing national problem. Adolesc Med Clin. 2006 Oct; 17(3):751-69; abstract xiii. PMID: 17030290.
    View in: PubMed
  56. Knight J, Holmes RP, Milliner DS, Monico CG, Cramer SD. Glyoxylate reductase activity in blood mononuclear cells and the diagnosis of primary hyperoxaluria type 2. Nephrol Dial Transplant. 2006 Aug; 21(8):2292-5. PMID: 16597637; PMCID: PMC1579247.
  57. Levy S, Harris SK, Sherritt L, Angulo M, Knight JR. Drug testing of adolescents in general medical clinics, in school and at home: physician attitudes and practices. J Adolesc Health. 2006 Apr; 38(4):336-42. PMID: 16549293.
    View in: PubMed
  58. Levy S, Harris SK, Sherritt L, Angulo M, Knight JR. Drug testing of adolescents in ambulatory medicine: physician practices and knowledge. Arch Pediatr Adolesc Med. 2006 Feb; 160(2):146-50. PMID: 16461869.
    View in: PubMed
  59. Burke PJ, Da Silva JD, Vaughan BL, Knight JR. Training high school counselors on the use of motivational interviewing to screen for substance abuse. Subst Abus. 2005 Dec; 26(3-4):31-4. PMID: 16837410.
    View in: PubMed
  60. Wilson CR, Sherritt L, Knight JR. Teaching Residents about Child Neglect and Parental Alcoholism: A Controlled Pilot Study. Med Educ Online. 2005 Dec; 10(1):4381. PMID: 28253138.
    View in: PubMed
  61. Bridgemohan CF, Levy S, Veluz AK, Knight JR. Teaching paediatric residents about learning disorders: use of standardised case discussion versus multimedia computer tutorial. Med Educ. 2005 Aug; 39(8):797-806. PMID: 16048622.
    View in: PubMed
  62. Knight J, Lively MO, Johnston N, Dettmar PW, Koufman JA. Sensitive pepsin immunoassay for detection of laryngopharyngeal reflux. Laryngoscope. 2005 Aug; 115(8):1473-8. PMID: 16094128.
    View in: PubMed
  63. Knight JR, Sherritt L, Van Hook S, Gates EC, Levy S, Chang G. Motivational interviewing for adolescent substance use: a pilot study. J Adolesc Health. 2005 Aug; 37(2):167-9. PMID: 16026730.
    View in: PubMed
  64. Chang G, Sherritt L, Knight JR. Adolescent cigarette smoking and mental health symptoms. J Adolesc Health. 2005 Jun; 36(6):517-22. PMID: 15901517.
    View in: PubMed
  65. Wolraich ML, Wibbelsman CJ, Brown TE, Evans SW, Gotlieb EM, Knight JR, Ross EC, Shubiner HH, Wender EH, Wilens T. Attention-deficit/hyperactivity disorder among adolescents: a review of the diagnosis, treatment, and clinical implications. Pediatrics. 2005 Jun; 115(6):1734-46. PMID: 15930238.
    View in: PubMed
  66. McCabe SE, Teter CJ, Boyd CJ, Knight JR, Wechsler H. Nonmedical use of prescription opioids among U.S. college students: prevalence and correlates from a national survey. Addict Behav. 2005 May; 30(4):789-805. PMID: 15833582.
    View in: PubMed
  67. Knight J, Holmes RP. Mitochondrial hydroxyproline metabolism: implications for primary hyperoxaluria. Am J Nephrol. 2005 Mar-Apr; 25(2):171-5. PMID: 15849464; PMCID: PMC4756647.
  68. McCabe SE, Knight JR, Teter CJ, Wechsler H. Non-medical use of prescription stimulants among US college students: prevalence and correlates from a national survey. Addiction. 2005 Jan; 100(1):96-106. PMID: 15598197.
    View in: PubMed
  69. Johnston N, Knight J, Dettmar PW, Lively MO, Koufman J. Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease. Laryngoscope. 2004 Dec; 114(12):2129-34. PMID: 15564833.
    View in: PubMed
  70. Wilson CR, Sherritt L, Gates E, Knight JR. Are clinical impressions of adolescent substance use accurate? Pediatrics. 2004 Nov; 114(5):e536-40. PMID: 15520086.
    View in: PubMed
  71. Knight JR. A 35-year-old physician with opioid dependence. JAMA. 2004 Sep 15; 292(11):1351-7. PMID: 15367558.
    View in: PubMed
  72. Roth EJ, Barreto P, Sherritt L, Palfrey JS, Risko W, Knight JR. A new, experiential curriculum in child advocacy for pediatric residents. Ambul Pediatr. 2004 Sep-Oct; 4(5):418-23. PMID: 15369412.
    View in: PubMed
  73. Levy S, Sherritt L, Harris SK, Gates EC, Holder DW, Kulig JW, Knight JR. Test-retest reliability of adolescents' self-report of substance use. Alcohol Clin Exp Res. 2004 Aug; 28(8):1236-41. PMID: 15318123.
    View in: PubMed
  74. Levy S, Van Hook S, Knight J. A review of Internet-based home drug-testing products for parents. Pediatrics. 2004 Apr; 113(4):720-6. PMID: 15060218.
    View in: PubMed
  75. Elgar FJ, Knight J, Worrall GJ, Sherman G. Behavioural and substance use problems in rural and urban delinquent youths. Can J Psychiatry. 2003 Oct; 48(9):633-6. PMID: 14631885.
    View in: PubMed
  76. Knight JR, Harris SK, Sherritt L, Kelley K, Van Hook S, Wechsler H. Heavy drinking and alcohol policy enforcement in a statewide public college system. J Stud Alcohol. 2003 Sep; 64(5):696-703. PMID: 14572192.
    View in: PubMed
  77. Shrier LA, Harris SK, Kurland M, Knight JR. Substance use problems and associated psychiatric symptoms among adolescents in primary care. Pediatrics. 2003 Jun; 111(6 Pt 1):e699-705. PMID: 12777588.
    View in: PubMed
  78. Brooks TL, Woods ER, Knight JR, Shrier LA. Body modification and substance use in adolescents: is there a link? J Adolesc Health. 2003 Jan; 32(1):44-9. PMID: 12507800.
    View in: PubMed
  79. Knight JR, Sherritt L, Harris SK, Gates EC, Chang G. Validity of brief alcohol screening tests among adolescents: a comparison of the AUDIT, POSIT, CAGE, and CRAFFT. Alcohol Clin Exp Res. 2003 Jan; 27(1):67-73. PMID: 12544008.
    View in: PubMed
  80. Knight JR, Sherritt L, Shrier LA, Harris SK, Chang G. Validity of the CRAFFT substance abuse screening test among adolescent clinic patients. Arch Pediatr Adolesc Med. 2002 Jun; 156(6):607-14. PMID: 12038895.
    View in: PubMed
  81. Rigotti NA, Regan S, Majchrzak NE, Knight JR, Wechsler H. Tobacco use by Massachusetts public college students: long term effect of the Massachusetts Tobacco Control Program. Tob Control. 2002 Jun; 11 Suppl 2:ii20-4. PMID: 12034976; PMCID: PMC1766073.
  82. Knight JR, Wechsler H, Kuo M, Seibring M, Weitzman ER, Schuckit MA. Alcohol abuse and dependence among U.S. college students. J Stud Alcohol. 2002 May; 63(3):263-70. PMID: 12086126.
    View in: PubMed
  83. Levy S, Vaughan BL, Knight JR. Office-based intervention for adolescent substance abuse. Pediatr Clin North Am. 2002 Apr; 49(2):329-43. PMID: 11993286.
    View in: PubMed
  84. Knight JR, Sanchez LT, Sherritt L, Bresnahan LR, Silveria JM, Fromson JA. Monitoring physician drug problems: attitudes of participants. J Addict Dis. 2002; 21(4):27-36. PMID: 12296499.
    View in: PubMed
  85. Knight JR, Goodman E, Pulerwitz T, DuRant RH. Reliability of the Problem Oriented Screening Instrument for Teenagers (POSIT) in adolescent medical practice. J Adolesc Health. 2001 Aug; 29(2):125-30. PMID: 11472871.
    View in: PubMed
  86. Knight JR, Frazer CH, Goodman E, Blaschke GS, Bravender TD, Emans SJ. Development of a Bright Futures curriculum for pediatric residents. Ambul Pediatr. 2001 May-Jun; 1(3):136-40. PMID: 11888390.
    View in: PubMed
  87. Knight JR. The role of the primary care provider in preventing and treating alcohol problems in adolescents. Ambul Pediatr. 2001 May-Jun; 1(3):150-61. PMID: 11888392.
    View in: PubMed
  88. Knight JR, Palacios J, Shannon M. Unanticipated reactions to a recent report on alcohol problems among pediatric residents. Arch Pediatr Adolesc Med. 2000 Jun; 154(6):635. PMID: 10850517.
    View in: PubMed
  89. Bravender T, Goodman E, Knight J, Frazer C, Luoni M, Blaschke G, Emans SJ. Case-based teaching in adolescent medicine. J Adolesc Health. 2000 Apr; 26(4):241-2. PMID: 10798853.
    View in: PubMed
  90. Knight JR, Goodman E, Pulerwitz T, DuRant RH. Reliabilities of short substance abuse screening tests among adolescent medical patients. Pediatrics. 2000 Apr; 105(4 Pt 2):948-53. PMID: 10742352.
    View in: PubMed
  91. Knight JR, Palacios JN, Shannon M. Prevalence of alcohol problems among pediatric residents. Arch Pediatr Adolesc Med. 1999 Nov; 153(11):1181-3. PMID: 10555722.
    View in: PubMed
  92. Frazer C, Emans SJ, Goodman E, Luoni M, Bravender T, Knight J. Teaching residents about development and behavior: meeting the new challenge. Arch Pediatr Adolesc Med. 1999 Nov; 153(11):1190-4. PMID: 10555724.
    View in: PubMed
  93. Knight JR, Shrier LA, Bravender TD, Farrell M, Vander Bilt J, Shaffer HJ. A new brief screen for adolescent substance abuse. Arch Pediatr Adolesc Med. 1999 Jun; 153(6):591-6. PMID: 10357299.
    View in: PubMed
  94. Emans SJ, Bravender T, Knight J, Frazer C, Luoni M, Berkowitz C, Armstrong E, Goodman E. Adolescent medicine training in pediatric residency programs: are we doing a good job? Pediatrics. 1998 Sep; 102(3 Pt 1):588-95. PMID: 9738181.
    View in: PubMed
  95. Bravender T, Knight JR. Recent patterns of use and associated risks of illicit drug use in adolescents. Curr Opin Pediatr. 1998 Aug; 10(4):344-9. PMID: 9757357.
    View in: PubMed
  96. Durant RH, Knight J, Goodman E. Factors associated with aggressive and delinquent behaviors among patients attending an adolescent medicine clinic. J Adolesc Health. 1997 Nov; 21(5):303-8. PMID: 9358293.
    View in: PubMed
  97. Goodman E, Knight JR, DuRant RH. Use of the Life Optimism Test among adolescents in a clinical setting: a report of reliability testing. J Adolesc Health. 1997 Oct; 21(4):218-20. PMID: 9304451.
    View in: PubMed
  98. Vaughn BL, Knight JR. Self-induced vomiting as a presentation of abdominal mass. Pediatrics. 1997 May; 99(5):731-3. PMID: 9113952.
    View in: PubMed
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