Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Cesar Martin Castro, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01CA233360 (LEE, HAKHO) Sep 1, 2018 - Jul 31, 2023
    Early Detection through Novel OCEAN Technology - Ovarian Cancer Exosomal Analysis with Nanoplasmonics
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. O'Malley DM, Matulonis UA, Birrer MJ, Castro CM, Gilbert L, Vergote I, Martin LP, Mantia-Smaldone GM, Martin AG, Bratos R, Penson RT, Malek K, Moore KN. Phase Ib study of mirvetuximab soravtansine, a folate receptor alpha (FRa)-targeting antibody-drug conjugate (ADC), in combination with bevacizumab in patients with platinum-resistant ovarian cancer. Gynecol Oncol. 2020 May; 157(2):379-385. PMID: 32081463.
  2. Pathania D, Landeros C, Rohrer L, D'Agostino V, Hong S, Degani I, Avila-Wallace M, Pivovarov M, Randall T, Weissleder R, Lee H, Im H, Castro CM. Point-of-care cervical cancer screening using deep learning-based microholography. Theranostics. 2019; 9(26):8438-8447. PMID: 31879529.
  3. Liu JF, Herold C, Gray KP, Penson RT, Horowitz N, Konstantinopoulos PA, Castro CM, Hill SJ, Curtis J, Luo W, Matulonis UA, Cannistra SA, Dizon DS. Assessment of Combined Nivolumab and Bevacizumab in Relapsed Ovarian Cancer: A Phase 2 Clinical Trial. JAMA Oncol. 2019 Oct 10. PMID: 31600397.
  4. Huang CH, Park YI, Lin HY, Pathania D, Park KS, Avila-Wallace M, Castro CM, Weissleder R, Lee H. Compact and Filter-Free Luminescence Biosensor for Mobile in Vitro Diagnoses. ACS Nano. 2019 10 22; 13(10):11698-11706. PMID: 31461265.
  5. Lee H, Castro CM. Thermophoretically enriched detection. Nat Biomed Eng. 2019 03; 3(3):163-164. PMID: 30948812.
  6. Kim SJ, Wang C, Zhao B, Im H, Min J, Choi HJ, Tadros J, Choi NR, Castro CM, Weissleder R, Lee H, Lee K. Deep transfer learning-based hologram classification for molecular diagnostics. Sci Rep. 2018 11 19; 8(1):17003. PMID: 30451953.
    Citations:    Fields:    
  7. Huber S, Min C, Staat C, Oh J, Castro CM, Haase A, Weissleder R, Gleich B, Lee H. Multichannel digital heteronuclear magnetic resonance biosensor. Biosens Bioelectron. 2019 Feb 01; 126:240-248. PMID: 30445298.
    Citations:    Fields:    
  8. Min J, Im H, Allen M, McFarland PJ, Degani I, Yu H, Normandin E, Pathania D, Patel JM, Castro CM, Weissleder R, Lee H. Computational Optics Enables Breast Cancer Profiling in Point-of-Care Settings. ACS Nano. 2018 09 25; 12(9):9081-9090. PMID: 30113824.
    Citations:    Fields:    
  9. Im H, Pathania D, McFarland PJ, Sohani AR, Degani I, Allen M, Coble B, Kilcoyne A, Hong S, Rohrer L, Abramson JS, Dryden-Peterson S, Fexon L, Pivovarov M, Chabner B, Lee H, Castro CM, Weissleder R. Design and clinical validation of a point-of-care device for the diagnosis of lymphoma via contrast-enhanced microholography and machine learning. Nat Biomed Eng. 2018 Sep; 2(9):666-674. PMID: 30555750.
  10. Min J, Nothing M, Coble B, Zheng H, Park J, Im H, Weber GF, Castro CM, Swirski FK, Weissleder R, Lee H. Integrated Biosensor for Rapid and Point-of-Care Sepsis Diagnosis. ACS Nano. 2018 04 24; 12(4):3378-3384. PMID: 29533646.
    Citations:    Fields:    
  11. Shao H, Im H, Castro CM, Breakefield X, Weissleder R, Lee H. New Technologies for Analysis of Extracellular Vesicles. Chem Rev. 2018 02 28; 118(4):1917-1950. PMID: 29384376.
    Citations: 2     Fields:    
  12. Min C, Park J, Mun JK, Lim Y, Min J, Lim JW, Kang DM, Ahn HK, Shin TH, Cheon J, Lee HS, Weissleder R, Castro CM, Lee H. Integrated microHall magnetometer to measure the magnetic properties of nanoparticles. Lab Chip. 2017 11 21; 17(23):4000-4007. PMID: 29067383.
    Citations:    Fields:    Translation:HumansCells
  13. Park J, Im H, Hong S, Castro CM, Weissleder R, Lee H. Analyses of Intravesicular Exosomal Proteins Using a Nano-Plasmonic System. ACS Photonics. 2018 Feb 21; 5(2):487-494. PMID: 29805987.
    Citations: 1     
  14. Park J, Lin HY, Assaker JP, Jeong S, Huang CH, Kurdi T, Lee K, Fraser K, Min C, Eskandari S, Routray S, Tannous B, Abdi R, Riella L, Chandraker A, Castro CM, Weissleder R, Lee H, Azzi JR. Integrated Kidney Exosome Analysis for the Detection of Kidney Transplant Rejection. ACS Nano. 2017 11 28; 11(11):11041-11046. PMID: 29053921.
    Citations: 2     Fields:    Translation:HumansCells
  15. Oza AM, Tinker AV, Oaknin A, Shapira-Frommer R, McNeish IA, Swisher EM, Ray-Coquard I, Bell-McGuinn K, Coleman RL, O'Malley DM, Leary A, Chen LM, Provencher D, Ma L, Brenton JD, Konecny GE, Castro CM, Giordano H, Maloney L, Goble S, Lin KK, Sun J, Raponi M, Rolfe L, Kristeleit RS. Antitumor activity and safety of the PARP inhibitor rucaparib in patients with high-grade ovarian carcinoma and a germline or somatic BRCA1 or BRCA2 mutation: Integrated analysis of data from Study 10 and ARIEL2. Gynecol Oncol. 2017 11; 147(2):267-275. PMID: 28882436.
    Citations: 7     Fields:    Translation:HumansCTClinical Trials
  16. Lin HY, Huang CH, Park J, Pathania D, Castro CM, Fasano A, Weissleder R, Lee H. Integrated Magneto-Chemical Sensor For On-Site Food Allergen Detection. ACS Nano. 2017 10 24; 11(10):10062-10069. PMID: 28792732.
    Citations: 1     Fields:    
  17. Im H, Lee K, Weissleder R, Lee H, Castro CM. Novel nanosensing technologies for exosome detection and profiling. Lab Chip. 2017 08 22; 17(17):2892-2898. PMID: 28745363.
    Citations: 2     Fields:    Translation:HumansCells
  18. Yang KS, Im H, Hong S, Pergolini I, Del Castillo AF, Wang R, Clardy S, Huang CH, Pille C, Ferrone S, Yang R, Castro CM, Lee H, Del Castillo CF, Weissleder R. Multiparametric plasma EV profiling facilitates diagnosis of pancreatic malignancy. Sci Transl Med. 2017 05 24; 9(391). PMID: 28539469.
    Citations: 8     Fields:    Translation:Humans
  19. Hong S, Park KS, Weissleder R, Castro CM, Lee H. Facile silicification of plastic surface for bioassays. Chem Commun (Camb). 2017 Feb 09; 53(13):2134-2137. PMID: 28134385.
    Citations:    Fields:    Translation:HumansCells
  20. Castro CM. Good to the last "emulsified" drop. Sci Transl Med. 2017 01 18; 9(373). PMID: 28100835.
    Citations:    Fields:    
  21. Im H, Yang K, Lee H, Castro CM. Characterization of Extracellular Vesicles by Surface Plasmon Resonance. Methods Mol Biol. 2017; 1660:133-141. PMID: 28828653.
    Citations:    Fields:    Translation:HumansCells
  22. Castro CM. Taking cancer drug screening very personally. Sci Transl Med. 2016 11 30; 8(367):367ec190. PMID: 27903858.
    Citations:    Fields:    Translation:Humans
  23. Park YI, Kim E, Huang CH, Park KS, Castro CM, Lee H, Weissleder R. Facile Coating Strategy to Functionalize Inorganic Nanoparticles for Biosensing. Bioconjug Chem. 2017 01 18; 28(1):33-37. PMID: 27792877.
    Citations: 1     Fields:    
  24. Pathania D, Im H, Kilcoyne A, Sohani AR, Fexon L, Pivovarov M, Abramson JS, Randall TC, Chabner BA, Weissleder R, Lee H, Castro CM. Holographic Assessment of Lymphoma Tissue (HALT) for Global Oncology Field Applications. Theranostics. 2016; 6(10):1603-10. PMID: 27446494.
    Citations:    Fields:    
  25. Sosulski A, Horn H, Zhang L, Coletti C, Vathipadiekal V, Castro CM, Birrer MJ, Nagano O, Saya H, Lage K, Donahoe PK, Pépin D. CD44 Splice Variant v8-10 as a Marker of Serous Ovarian Cancer Prognosis. PLoS One. 2016; 11(6):e0156595. PMID: 27253518.
    Citations: 10     Fields:    Translation:HumansCells
  26. Park KS, Huang CH, Lee K, Yoo YE, Castro CM, Weissleder R, Lee H. Rapid identification of health care-associated infections with an integrated fluorescence anisotropy system. Sci Adv. 2016 05; 2(5):e1600300. PMID: 28861468.
    Citations: 2     Fields:    Translation:HumansCells
  27. Im H, Park YI, Pathania D, Castro CM, Weissleder R, Lee H. Digital diffraction detection of protein markers for avian influenza. Lab Chip. 2016 Apr 21; 16(8):1340-5. PMID: 26980325.
    Citations:    Fields:    Translation:AnimalsCells
  28. Penson RT, Sales E, Sullivan L, Borger DR, Krasner CN, Goodman AK, del Carmen MG, Growdon WB, Schorge JO, Boruta DM, Castro CM, Dizon DS, Birrer MJ. A SNaPshot of potentially personalized care: Molecular diagnostics in gynecologic cancer. Gynecol Oncol. 2016 Apr; 141(1):108-12. PMID: 27016236.
    Citations:    Fields:    Translation:Humans
  29. Im H, Lee H, Castro CM. Challenges influencing next generation technologies for precision medicine. Expert Rev Precis Med Drug Dev. 2016; 1(2):121-123. PMID: 28008420.
  30. Jeong S, Park J, Pathania D, Castro CM, Weissleder R, Lee H. Integrated Magneto-Electrochemical Sensor for Exosome Analysis. ACS Nano. 2016 Feb 23; 10(2):1802-9. PMID: 26808216.
    Citations: 17     Fields:    Translation:HumansCells
  31. Pépin D, Sosulski A, Zhang L, Wang D, Vathipadiekal V, Hendren K, Coletti CM, Yu A, Castro CM, Birrer MJ, Gao G, Donahoe PK. AAV9 delivering a modified human Mullerian inhibiting substance as a gene therapy in patient-derived xenografts of ovarian cancer. Proc Natl Acad Sci U S A. 2015 Aug 11; 112(32):E4418-27. PMID: 26216943.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  32. Im H, Shao H, Weissleder R, Castro CM, Lee H. Nano-plasmonic exosome diagnostics. Expert Rev Mol Diagn. 2015 Jun; 15(6):725-33. PMID: 25936957.
    Citations: 4     Fields:    Translation:HumansCells
  33. Turetsky A, Lee K, Song J, Giedt RJ, Kim E, Kovach AE, Hochberg EP, Castro CM, Lee H, Weissleder R. On chip analysis of CNS lymphoma in cerebrospinal fluid. Theranostics. 2015; 5(8):796-804. PMID: 26000053.
    Citations: 1     Fields:    Translation:Humans
  34. Im H, Castro CM, Shao H, Liong M, Song J, Pathania D, Fexon L, Min C, Avila-Wallace M, Zurkiya O, Rho J, Magaoay B, Tambouret RH, Pivovarov M, Weissleder R, Lee H. Digital diffraction analysis enables low-cost molecular diagnostics on a smartphone. Proc Natl Acad Sci U S A. 2015 May 05; 112(18):5613-8. PMID: 25870273.
    Citations: 11     Fields:    Translation:HumansCells
  35. Castro CM, Im H, Le C, Lee H, Weissleder R, Birrer MJ. Exploring alternative ovarian cancer biomarkers using innovative nanotechnology strategies. Cancer Metastasis Rev. 2015 Mar; 34(1):75-82. PMID: 25543192.
    Citations: 1     Fields:    Translation:HumansCells
  36. Im H, Shao H, Park YI, Peterson VM, Castro CM, Weissleder R, Lee H. Label-free detection and molecular profiling of exosomes with a nano-plasmonic sensor. Nat Biotechnol. 2014 May; 32(5):490-5. PMID: 24752081.
    Citations: 109     Fields:    Translation:HumansCells
  37. Ullal AV, Peterson V, Agasti SS, Tuang S, Juric D, Castro CM, Weissleder R. Cancer cell profiling by barcoding allows multiplexed protein analysis in fine-needle aspirates. Sci Transl Med. 2014 Jan 15; 6(219):219ra9. PMID: 24431113.
    Citations: 29     Fields:    Translation:HumansCells
  38. Peterson VM, Castro CM, Chung J, Miller NC, Ullal AV, Castano MD, Penson RT, Lee H, Birrer MJ, Weissleder R. Ascites analysis by a microfluidic chip allows tumor-cell profiling. Proc Natl Acad Sci U S A. 2013 Dec 17; 110(51):E4978-86. PMID: 24297935.
    Citations: 14     Fields:    Translation:HumansCTClinical Trials
  39. Rho J, Chung J, Im H, Liong M, Shao H, Castro CM, Weissleder R, Lee H. Magnetic nanosensor for detection and profiling of erythrocyte-derived microvesicles. ACS Nano. 2013 Dec 23; 7(12):11227-33. PMID: 24295203.
    Citations: 17     Fields:    Translation:HumansCells
  40. Ghazani AA, Pectasides M, Sharma A, Castro CM, Mino-Kenudson M, Lee H, Shepard JA, Weissleder R. Molecular characterization of scant lung tumor cells using iron-oxide nanoparticles and micro-nuclear magnetic resonance. Nanomedicine. 2014 Apr; 10(3):661-8. PMID: 24200523.
    Citations: 11     Fields:    Translation:HumansCells
  41. Castro CM, Ghazani AA, Chung J, Shao H, Issadore D, Yoon TJ, Weissleder R, Lee H. Miniaturized nuclear magnetic resonance platform for detection and profiling of circulating tumor cells. Lab Chip. 2014 Jan 07; 14(1):14-23. PMID: 23835814.
    Citations: 9     Fields:    Translation:HumansCells
  42. Keliher EJ, Reiner T, Earley S, Klubnick J, Tassa C, Lee AJ, Ramaswamy S, Bardeesy N, Hanahan D, Depinho RA, Castro CM, Weissleder R. Targeting cathepsin E in pancreatic cancer by a small molecule allows in vivo detection. Neoplasia. 2013 Jul; 15(7):684-93. PMID: 23814481.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  43. Chung HJ, Castro CM, Im H, Lee H, Weissleder R. A magneto-DNA nanoparticle system for rapid detection and phenotyping of bacteria. Nat Nanotechnol. 2013 May; 8(5):369-75. PMID: 23644570.
    Citations: 35     Fields:    Translation:HumansCells
  44. Ghazani AA, McDermott S, Pectasides M, Sebas M, Mino-Kenudson M, Lee H, Weissleder R, Castro CM. Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system. Nanomedicine. 2013 Oct; 9(7):1009-17. PMID: 23570873.
    Citations: 7     Fields:    Translation:HumansCells
  45. Issadore D, Chung J, Shao H, Liong M, Ghazani AA, Castro CM, Weissleder R, Lee H. Ultrasensitive clinical enumeration of rare cells ex vivo using a micro-hall detector. Sci Transl Med. 2012 Jul 04; 4(141):141ra92. PMID: 22764208.
    Citations: 58     Fields:    Translation:HumansCells
  46. Ghazani AA, Castro CM, Gorbatov R, Lee H, Weissleder R. Sensitive and direct detection of circulating tumor cells by multimarker µ-nuclear magnetic resonance. Neoplasia. 2012 May; 14(5):388-95. PMID: 22745585.
    Citations: 16     Fields:    Translation:HumansCells
  47. Peterson VM, Castro CM, Lee H, Weissleder R. Orthogonal amplification of nanoparticles for improved diagnostic sensing. ACS Nano. 2012 Apr 24; 6(4):3506-13. PMID: 22424443.
    Citations: 5     Fields:    Translation:HumansCells
  48. Weissleder R, Castro C. Interview: Nanomedicine in oncology: miniaturized means to an enormous end. Interviewed by Cara Sutton. Nanomedicine (Lond). 2011 Nov; 6(9):1495-8. PMID: 22077461.
    Citations:    Fields:    Translation:Humans
  49. Haun JB, Castro CM, Wang R, Peterson VM, Marinelli BS, Lee H, Weissleder R. Micro-NMR for rapid molecular analysis of human tumor samples. Sci Transl Med. 2011 Feb 23; 3(71):71ra16. PMID: 21346169.
    Citations: 58     Fields:    Translation:Humans
  50. Perez DL, Diamond EL, Castro CM, Diaz A, Buonanno F, Nogueira RG, Sheth K. Factor XIII deficiency related recurrent spontaneous intracerebral hemorrhage: a case and literature review. Clin Neurol Neurosurg. 2011 Feb; 113(2):142-5. PMID: 20950938.
    Citations: 1     Fields:    Translation:Humans
  51. Penson RT, Castro CM, Seiden MV, Chabner BA, Lynch TJ. Complementary, alternative, integrative, or unconventional medicine? Oncologist. 2001; 6(5):463-73. PMID: 11675526.
    Citations: 7     Fields:    Translation:Humans
  52. Castro CM, Yang Y, Zhang Z, Linnoila RI. Attenuation of pulmonary neuroendocrine differentiation in mice lacking Clara cell secretory protein. Lab Invest. 2000 Oct; 80(10):1533-40. PMID: 11045570.
    Citations: 6     Fields:    Translation:AnimalsCells
Local representatives can answer questions about the Profiles website or help with editing a profile or issues with profile data. For assistance with this profile: HMS/HSDM faculty should contact feedbackcatalyst.harvard.edu. For faculty or fellow appointment updates and changes, please ask your appointing department to contact HMS. For fellow personal and demographic information, contact HMS Human Resources at human_resourceshms.harvard.edu. For faculty personal and demographic information, contact HMS Office for Faculty Affairs at facappthms.harvard.edu.
Castro's Networks
Click the
buttons for more information and interactive visualizations!
Concepts (211)
Co-Authors (44)
Similar People (60)
Same Department 
Physical Neighbors
Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.