Harvard Catalyst Profiles

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Susan Rider Rittling, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01DE022380 (RITTLING, SUSAN R) Jul 18, 2012 - Apr 30, 2018
    Osteopontin and Integrins in Innate Immune Responses to Polymicrobial Infection
    Role: Principal Investigator
  2. R01DK067685 (RITTLING, SUSAN R) Sep 1, 2003 - Aug 31, 2008
    Osteopontin and Molecular Mechanisms of Bone Metastasis
    Role: Principal Investigator
  3. R01CA072740 (RITTLING, SUSAN R) Jul 1, 1997 - Jun 30, 2002
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Johnston CD, Cotton SL, Rittling SR, Starr JR, Borisy GG, Dewhirst FE, Lemon KP. Systematic evasion of the restriction-modification barrier in bacteria. Proc Natl Acad Sci U S A. 2019 06 04; 116(23):11454-11459. PMID: 31097593.
    Citations: 12     Fields:    Translation:Cells
  2. Johnston CD, Skeete CA, Fomenkov A, Roberts RJ, Rittling SR. Restriction-modification mediated barriers to exogenous DNA uptake and incorporation employed by Prevotella intermedia. PLoS One. 2017; 12(9):e0185234. PMID: 28934361.
    Citations: 8     Fields:    Translation:HumansCells
  3. Wisitrasameewong W, Kajiya M, Movila A, Rittling S, Ishii T, Suzuki M, Matsuda S, Mazda Y, Torruella MR, Azuma MM, Egashira K, Freire MO, Sasaki H, Wang CY, Han X, Taubman MA, Kawai T. DC-STAMP Is an Osteoclast Fusogen Engaged in Periodontal Bone Resorption. J Dent Res. 2017 Jun; 96(6):685-693. PMID: 28199142; PMCID: PMC5444615.
    Citations: 13     Fields:    Translation:AnimalsCells
  4. Singh R, Hui T, Matsui A, Allahem Z, Johnston CD, Ruiz-Torruella M, Rittling SR. Modulation of infection-mediated migration of neutrophils and CXCR2 trafficking by osteopontin. Immunology. 2017 Jan; 150(1):74-86. PMID: 27599164.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  5. Rittling SR, Singh R. Osteopontin in Immune-mediated Diseases. J Dent Res. 2015 Dec; 94(12):1638-45. PMID: 26341976; PMCID: PMC4681477.
    Citations: 56     Fields:    Translation:Humans
  6. Matsui A, Stephens D, Kantarci A, Rittling SR. Early Cytokine Response to Infection with Pathogenic vs Non-Pathogenic Organisms in a Mouse Model of Endodontic Infection. PLoS One. 2015; 10(7):e0132752. PMID: 26171605.
    Citations: 1     Fields:    Translation:Animals
  7. Hui T, Sørensen ES, Rittling SR. Osteopontin binding to the alpha 4 integrin requires highest affinity integrin conformation, but is independent of post-translational modifications of osteopontin. Matrix Biol. 2015 Jan; 41:19-25. PMID: 25446551; PMCID: PMC4912046.
    Citations: 12     Fields:    Translation:HumansCells
  8. Matsui A, Jin JO, Johnston CD, Yamazaki H, Houri-Haddad Y, Rittling SR. Pathogenic bacterial species associated with endodontic infection evade innate immune control by disabling neutrophils. Infect Immun. 2014 Oct; 82(10):4068-79. PMID: 25024367.
    Citations: 11     Fields:    Translation:AnimalsCells
  9. Ezura Y, Nagata J, Nagao M, Hemmi H, Hayata T, Rittling S, Denhardt DT, Noda M. Hindlimb-unloading suppresses B cell population in the bone marrow and peripheral circulation associated with OPN expression in circulating blood cells. J Bone Miner Metab. 2015 Jan; 33(1):48-54. PMID: 24831120.
    Citations: 1     Fields:    Translation:AnimalsCells
  10. Rittling SR, Wejse PL, Yagiz K, Warot GA, Hui T. Suppression of tumour growth by orally administered osteopontin is accompanied by alterations in tumour blood vessels. Br J Cancer. 2014 Mar 04; 110(5):1269-77. PMID: 24473400.
    Citations: 4     Fields:    Translation:AnimalsCells
  11. Diao H, Liu X, Wu Z, Kang L, Cui G, Morimoto J, Denhardt DT, Rittling S, Iwakura Y, Uede T, Li L. Osteopontin regulates interleukin-17 production in hepatitis. Cytokine. 2012 Oct; 60(1):129-37. PMID: 22818182.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  12. Yumoto K, Nifuji A, Rittling SR, Tsuchiya Y, Kon S, Uede T, Denhardt DT, Hemmi H, Notomi T, Hayata T, Ezura Y, Nakamoto T, Noda M. Osteopontin Deficiency Suppresses Tumor Necrosis Factor-a-Induced Apoptosis in Chondrocytes. Cartilage. 2012 Jan; 3(1):79-85. PMID: 26069621.
    Citations: 8     Fields:    
  13. Nagao M, Feinstein TN, Ezura Y, Hayata T, Notomi T, Saita Y, Hanyu R, Hemmi H, Izu Y, Takeda S, Wang K, Rittling S, Nakamoto T, Kaneko K, Kurosawa H, Karsenty G, Denhardt DT, Vilardaga JP, Noda M. Sympathetic control of bone mass regulated by osteopontin. Proc Natl Acad Sci U S A. 2011 Oct 25; 108(43):17767-72. PMID: 21990347.
    Citations: 26     Fields:    Translation:AnimalsCells
  14. Rittling SR. Osteopontin in macrophage function. Expert Rev Mol Med. 2011 Apr 26; 13:e15. PMID: 21545755.
    Citations: 44     Fields:    Translation:HumansAnimalsCells
  15. Morishita M, Ono N, Miyai K, Nakagawa T, Hanyu R, Nagao M, Kamolratanakul P, Notomi T, Rittling SR, Denhardt DT, Kronenberg HM, Ezura Y, Hayata T, Nakamoto T, Noda M. Osteopontin deficiency enhances parathyroid hormone/ parathyroid hormone related peptide receptor (PPR) signaling-induced alteration in tooth formation and odontoblastic morphology. Tissue Cell. 2011 Jun; 43(3):196-200. PMID: 21511320.
    Citations: 2     Fields:    Translation:AnimalsCells
  16. Zhang ZX, Shek K, Wang S, Huang X, Lau A, Yin Z, Sun H, Liu W, Garcia B, Rittling S, Jevnikar AM. Osteopontin expressed in tubular epithelial cells regulates NK cell-mediated kidney ischemia reperfusion injury. J Immunol. 2010 Jul 15; 185(2):967-73. PMID: 20548025.
    Citations: 31     Fields:    Translation:AnimalsCells
  17. Shimizu S, Okuda N, Kato N, Rittling SR, Okawa A, Shinomiya K, Muneta T, Denhardt DT, Noda M, Tsuji K, Asou Y. Osteopontin deficiency impairs wear debris-induced osteolysis via regulation of cytokine secretion from murine macrophages. Arthritis Rheum. 2010 May; 62(5):1329-37. PMID: 20155835.
    Citations: 15     Fields:    Translation:AnimalsCells
  18. Kurokawa M, Konno S, Takahashi A, Plunkett B, Rittling SR, Matsui Y, Kon S, Morimoto J, Uede T, Matsukura S, Kokubu F, Adachi M, Nishimura M, Huang SK. Regulatory role of DC-derived osteopontin in systemic allergen sensitization. Eur J Immunol. 2009 Dec; 39(12):3323-30. PMID: 19830723.
    Citations: 6     Fields:    Translation:AnimalsCells
  19. Kwok S, Rittling SR, Partridge NC, Benson CS, Thiyagaraj M, Srinivasan N, Selvamurugan N. Transforming growth factor-beta1 regulation of ATF-3 and identification of ATF-3 target genes in breast cancer cells. J Cell Biochem. 2009 Oct 01; 108(2):408-14. PMID: 19582787.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  20. Monfoulet L, Malaval L, Aubin JE, Rittling SR, Gadeau AP, Fricain JC, Chassande O. Bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing. Bone. 2010 Feb; 46(2):447-52. PMID: 19761880.
    Citations: 16     Fields:    Translation:Animals
  21. Rittling SR, Zetterberg C, Yagiz K, Skinner S, Suzuki N, Fujimura A, Sasaki H. Protective role of osteopontin in endodontic infection. Immunology. 2010 Jan; 129(1):105-14. PMID: 19824920.
    Citations: 6     Fields:    Translation:Animals
  22. Fujita N, Fujita S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T, Rittling SR, Denhardt DT, Saika S. Impaired angiogenic response in the corneas of mice lacking osteopontin. Invest Ophthalmol Vis Sci. 2010 Feb; 51(2):790-4. PMID: 19741245.
    Citations: 8     Fields:    Translation:AnimalsCells
  23. Matsui Y, Iwasaki N, Kon S, Takahashi D, Morimoto J, Matsui Y, Denhardt DT, Rittling S, Minami A, Uede T. Accelerated development of aging-associated and instability-induced osteoarthritis in osteopontin-deficient mice. Arthritis Rheum. 2009 Aug; 60(8):2362-71. PMID: 19644889.
    Citations: 37     Fields:    Translation:Animals
  24. Yagiz K, Rittling SR. Both cell-surface and secreted CSF-1 expressed by tumor cells metastatic to bone can contribute to osteoclast activation. Exp Cell Res. 2009 Aug 15; 315(14):2442-52. PMID: 19427849.
    Citations: 11     Fields:    Translation:AnimalsCells
  25. Maeno Y, Shinzato M, Nagashima S, Rittling SR, Denhardt DT, Uede T, Taniguchi K. Effect of osteopontin on diarrhea duration and innate immunity in suckling mice infected with a murine rotavirus. Viral Immunol. 2009 Apr; 22(2):139-44. PMID: 19327001.
    Citations: 4     Fields:    Translation:AnimalsCells
  26. Diao H, Iwabuchi K, Li L, Onoe K, Van Kaer L, Kon S, Saito Y, Morimoto J, Denhardt DT, Rittling S, Uede T. Osteopontin regulates development and function of invariant natural killer T cells. Proc Natl Acad Sci U S A. 2008 Oct 14; 105(41):15884-9. PMID: 18836077; PMCID: PMC2560993.
    Citations: 22     Fields:    Translation:AnimalsCells
  27. Leen LL, Filipe C, Billon A, Garmy-Susini B, Jalvy S, Robbesyn F, Daret D, Allières C, Rittling SR, Werner N, Nickenig G, Deutsch U, Duplàa C, Dufourcq P, Lenfant F, Desgranges C, Arnal JF, Gadeau AP. Estrogen-stimulated endothelial repair requires osteopontin. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12):2131-6. PMID: 18772499.
    Citations: 10     Fields:    Translation:AnimalsCells
  28. Sato I, Yamamoto N, Rittling SR, Denhardt DT, Hino M, Morimoro J, Sakai F, Fujie A, Uede T. Osteopontin is dispensable for protection against high load systemic fungal infection. Int Immunopharmacol. 2008 Oct; 8(10):1441-8. PMID: 18590834.
    Citations: 3     Fields:    Translation:AnimalsCells
  29. Borges K, Gearing M, Rittling S, Sorensen ES, Kotloski R, Denhardt DT, Dingledine R. Characterization of osteopontin expression and function after status epilepticus. Epilepsia. 2008 Oct; 49(10):1675-85. PMID: 18522644.
    Citations: 12     Fields:    Translation:AnimalsCells
  30. Ono N, Nakashima K, Rittling SR, Schipani E, Hayata T, Soma K, Denhardt DT, Kronenberg HM, Ezura Y, Noda M. Osteopontin negatively regulates parathyroid hormone receptor signaling in osteoblasts. J Biol Chem. 2008 Jul 11; 283(28):19400-9. PMID: 18417476.
    Citations: 14     Fields:    Translation:AnimalsCells
  31. Miyazaki K, Okada Y, Yamanaka O, Kitano A, Ikeda K, Kon S, Uede T, Rittling SR, Denhardt DT, Kao WW, Saika S. Corneal wound healing in an osteopontin-deficient mouse. Invest Ophthalmol Vis Sci. 2008 Apr; 49(4):1367-75. PMID: 18385052.
    Citations: 23     Fields:    Translation:AnimalsCells
  32. Chung CJ, Soma K, Rittling SR, Denhardt DT, Hayata T, Nakashima K, Ezura Y, Noda M. OPN deficiency suppresses appearance of odontoclastic cells and resorption of the tooth root induced by experimental force application. J Cell Physiol. 2008 Mar; 214(3):614-20. PMID: 17894420.
    Citations: 14     Fields:    Translation:AnimalsCells
  33. Kazanecki CC, Kowalski AJ, Ding T, Rittling SR, Denhardt DT. Characterization of anti-osteopontin monoclonal antibodies: Binding sensitivity to post-translational modifications. J Cell Biochem. 2007 Nov 01; 102(4):925-35. PMID: 17786932.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  34. Ramaiah SK, Rittling S. Pathophysiological role of osteopontin in hepatic inflammation, toxicity, and cancer. Toxicol Sci. 2008 May; 103(1):4-13. PMID: 17890765.
    Citations: 67     Fields:    Translation:HumansAnimals
  35. Ramaiah SK, Rittling S. Role of osteopontin in regulating hepatic inflammatory responses and toxic liver injury. Expert Opin Drug Metab Toxicol. 2007 Aug; 3(4):519-26. PMID: 17696803.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  36. Yates B, Zetterberg C, Rajeev V, Reiss M, Rittling SR. Promoter-independent regulation of vimentin expression in mammary epithelial cells by val(12)ras and TGFbeta. Exp Cell Res. 2007 Oct 15; 313(17):3718-28. PMID: 17719575; PMCID: PMC2097954.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  37. Hayashi C, Rittling S, Hayata T, Amagasa T, Denhardt D, Ezura Y, Nakashima K, Noda M. Serum osteopontin, an enhancer of tumor metastasis to bone, promotes B16 melanoma cell migration. J Cell Biochem. 2007 Jul 01; 101(4):979-86. PMID: 17390343.
    Citations: 27     Fields:    Translation:AnimalsCells
  38. Kitamura M, Iwabuchi K, Kitaichi N, Kon S, Kitamei H, Namba K, Yoshida K, Denhardt DT, Rittling SR, Ohno S, Uede T, Onoé K. Osteopontin aggravates experimental autoimmune uveoretinitis in mice. J Immunol. 2007 May 15; 178(10):6567-72. PMID: 17475887.
    Citations: 10     Fields:    Translation:AnimalsCells
  39. Christensen B, Kazanecki CC, Petersen TE, Rittling SR, Denhardt DT, Sørensen ES. Cell type-specific post-translational modifications of mouse osteopontin are associated with different adhesive properties. J Biol Chem. 2007 Jul 06; 282(27):19463-72. PMID: 17500062.
    Citations: 59     Fields:    Translation:HumansAnimalsCells
  40. Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Ezura Y, Noda M. Osteopontin is required for mechanical stress-dependent signals to bone marrow cells. J Endocrinol. 2007 May; 193(2):235-43. PMID: 17470514.
    Citations: 19     Fields:    Translation:AnimalsCells
  41. Kato N, Kitahara K, Rittling SR, Nakashima K, Denhardt DT, Kurosawa H, Ezura Y, Noda M. Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in bone. J Endocrinol. 2007 Apr; 193(1):171-82. PMID: 17400814.
    Citations: 1     Fields:    Translation:AnimalsCells
  42. Hashimoto M, Sun D, Rittling SR, Denhardt DT, Young W. Osteopontin-deficient mice exhibit less inflammation, greater tissue damage, and impaired locomotor recovery from spinal cord injury compared with wild-type controls. J Neurosci. 2007 Mar 28; 27(13):3603-11. PMID: 17392476; PMCID: PMC6672107.
    Citations: 47     Fields:    Translation:AnimalsCells
  43. Saika S, Shirai K, Yamanaka O, Miyazaki K, Okada Y, Kitano A, Flanders KC, Kon S, Uede T, Kao WW, Rittling SR, Denhardt DT, Ohnishi Y. Loss of osteopontin perturbs the epithelial-mesenchymal transition in an injured mouse lens epithelium. Lab Invest. 2007 Feb; 87(2):130-8. PMID: 17211411.
    Citations: 16     Fields:    Translation:AnimalsCells
  44. Mori N, Majima T, Iwasaki N, Kon S, Miyakawa K, Kimura C, Tanaka K, Denhardt DT, Rittling S, Minami A, Uede T. The role of osteopontin in tendon tissue remodeling after denervation-induced mechanical stress deprivation. Matrix Biol. 2007 Jan; 26(1):42-53. PMID: 17055235.
    Citations: 14     Fields:    Translation:AnimalsCells
  45. Da Silva AP, Pollett A, Rittling SR, Denhardt DT, Sodek J, Zohar R. Exacerbated tissue destruction in DSS-induced acute colitis of OPN-null mice is associated with downregulation of TNF-alpha expression and non-programmed cell death. J Cell Physiol. 2006 Sep; 208(3):629-39. PMID: 16741956.
    Citations: 29     Fields:    Translation:Animals
  46. Ge R, Rajeev V, Ray P, Lattime E, Rittling S, Medicherla S, Protter A, Murphy A, Chakravarty J, Dugar S, Schreiner G, Barnard N, Reiss M. Inhibition of growth and metastasis of mouse mammary carcinoma by selective inhibitor of transforming growth factor-beta type I receptor kinase in vivo. Clin Cancer Res. 2006 Jul 15; 12(14 Pt 1):4315-30. PMID: 16857807.
    Citations: 66     Fields:    Translation:HumansAnimals
  47. Ishijima M, Ezura Y, Tsuji K, Rittling SR, Kurosawa H, Denhardt DT, Emi M, Nifuji A, Noda M. Osteopontin is associated with nuclear factor kappaB gene expression during tail-suspension-induced bone loss. Exp Cell Res. 2006 Oct 01; 312(16):3075-83. PMID: 16889770.
    Citations: 12     Fields:    Translation:AnimalsCells
  48. Kuhn M, Shah S, Natasha T, Rittling SR. A mouse model of breast cancer metastasis to the choroid of the eye. Clin Exp Metastasis. 2005; 22(8):685-90. PMID: 16708307.
    Citations: 2     Fields:    Translation:Animals
  49. Lai CF, Seshadri V, Huang K, Shao JS, Cai J, Vattikuti R, Schumacher A, Loewy AP, Denhardt DT, Rittling SR, Towler DA. An osteopontin-NADPH oxidase signaling cascade promotes pro-matrix metalloproteinase 9 activation in aortic mesenchymal cells. Circ Res. 2006 Jun 23; 98(12):1479-89. PMID: 16709900.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  50. Maeno Y, Nakazawa S, Yamamoto N, Shinzato M, Nagashima S, Tanaka K, Sasaki J, Rittling SR, Denhardt DT, Uede T, Taniguchi K. Osteopontin participates in Th1-mediated host resistance against nonlethal malaria parasite Plasmodium chabaudi chabaudi infection in mice. Infect Immun. 2006 Apr; 74(4):2423-7. PMID: 16552072; PMCID: PMC1418913.
    Citations: 11     Fields:    Translation:AnimalsCells
  51. Koyama Y, Rittling SR, Tsuji K, Hino K, Salincarnboriboon R, Yano T, Taketani Y, Nifuji A, Denhardt DT, Noda M. Osteopontin deficiency suppresses high phosphate load-induced bone loss via specific modulation of osteoclasts. Endocrinology. 2006 Jun; 147(6):3040-9. PMID: 16513836.
    Citations: 11     Fields:    Translation:AnimalsCells
  52. Natasha T, Kuhn M, Kelly O, Rittling SR. Override of the osteoclast defect in osteopontin-deficient mice by metastatic tumor growth in the bone. Am J Pathol. 2006 Feb; 168(2):551-61. PMID: 16436669; PMCID: PMC1606503.
    Citations: 7     Fields:    Translation:AnimalsCells
  53. Vernon HJ, Osborne C, Tzortzaki EG, Yang M, Chen J, Rittling SR, Denhardt DT, Buyske S, Bledsoe SB, Evan AP, Fairbanks L, Simmonds HA, Tischfield JA, Sahota A. Aprt/Opn double knockout mice: osteopontin is a modifier of kidney stone disease severity. Kidney Int. 2005 Sep; 68(3):938-47. PMID: 16105024.
    Citations: 12     Fields:    Translation:AnimalsCells
  54. Lorena D, Darby IA, Gadeau AP, Leen LL, Rittling S, Porto LC, Rosenbaum J, Desmoulière A. Osteopontin expression in normal and fibrotic liver. altered liver healing in osteopontin-deficient mice. J Hepatol. 2006 Feb; 44(2):383-90. PMID: 16221502.
    Citations: 37     Fields:    Translation:Animals
  55. Evan AP, Coe FL, Rittling SR, Bledsoe SM, Shao Y, Lingeman JE, Worcester EM. Apatite plaque particles in inner medulla of kidneys of calcium oxalate stone formers: osteopontin localization. Kidney Int. 2005 Jul; 68(1):145-54. PMID: 15954903.
    Citations: 52     Fields:    Translation:Humans
  56. Kondo H, Nifuji A, Takeda S, Ezura Y, Rittling SR, Denhardt DT, Nakashima K, Karsenty G, Noda M. Unloading induces osteoblastic cell suppression and osteoclastic cell activation to lead to bone loss via sympathetic nervous system. J Biol Chem. 2005 Aug 26; 280(34):30192-200. PMID: 15961387.
    Citations: 51     Fields:    Translation:AnimalsCells
  57. Stier S, Ko Y, Forkert R, Lutz C, Neuhaus T, Grünewald E, Cheng T, Dombkowski D, Calvi LM, Rittling SR, Scadden DT. Osteopontin is a hematopoietic stem cell niche component that negatively regulates stem cell pool size. J Exp Med. 2005 Jun 06; 201(11):1781-91. PMID: 15928197; PMCID: PMC2213260.
    Citations: 245     Fields:    Translation:AnimalsCells
  58. Contractor T, Babiarz B, Kowalski AJ, Rittling SR, Sørensen ES, Denhardt DT. Osteoclasts resorb protein-free mineral (Osteologic discs) efficiently in the absence of osteopontin. In Vivo. 2005 Mar-Apr; 19(2):335-41. PMID: 15796195.
    Citations: 3     Fields:    Translation:AnimalsCells
  59. Rollo EE, Hempson SJ, Bansal A, Tsao E, Habib I, Rittling SR, Denhardt DT, Mackow ER, Shaw RD. The cytokine osteopontin modulates the severity of rotavirus diarrhea. J Virol. 2005 Mar; 79(6):3509-16. PMID: 15731245; PMCID: PMC1075680.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  60. Ohyama Y, Nemoto H, Rittling S, Tsuji K, Amagasa T, Denhardt DT, Nifuji A, Noda M. Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures. J Bone Miner Res. 2004 Oct; 19(10):1706-11. PMID: 15355566.
    Citations: 11     Fields:    Translation:AnimalsCells
  61. Diao H, Kon S, Iwabuchi K, Kimura C, Morimoto J, Ito D, Segawa T, Maeda M, Hamuro J, Nakayama T, Taniguchi M, Yagita H, Van Kaer L, Onóe K, Denhardt D, Rittling S, Uede T. Osteopontin as a mediator of NKT cell function in T cell-mediated liver diseases. Immunity. 2004 Oct; 21(4):539-50. PMID: 15485631.
    Citations: 84     Fields:    Translation:AnimalsCells
  62. Rittling SR, Chambers AF. Role of osteopontin in tumour progression. Br J Cancer. 2004 May 17; 90(10):1877-81. PMID: 15138464; PMCID: PMC2410284.
    Citations: 161     Fields:    Translation:HumansAnimals
  63. Matsui Y, Jia N, Okamoto H, Kon S, Onozuka H, Akino M, Liu L, Morimoto J, Rittling SR, Denhardt D, Kitabatake A, Uede T. Role of osteopontin in cardiac fibrosis and remodeling in angiotensin II-induced cardiac hypertrophy. Hypertension. 2004 Jun; 43(6):1195-201. PMID: 15123578.
    Citations: 62     Fields:    Translation:AnimalsCells
  64. Morimoto J, Inobe M, Kimura C, Kon S, Diao H, Aoki M, Miyazaki T, Denhardt DT, Rittling S, Uede T. Osteopontin affects the persistence of beta-glucan-induced hepatic granuloma formation and tissue injury through two distinct mechanisms. Int Immunol. 2004 Mar; 16(3):477-88. PMID: 14978021.
    Citations: 10     Fields:    Translation:AnimalsCells
  65. Zhu B, Suzuki K, Goldberg HA, Rittling SR, Denhardt DT, McCulloch CA, Sodek J. Osteopontin modulates CD44-dependent chemotaxis of peritoneal macrophages through G-protein-coupled receptors: evidence of a role for an intracellular form of osteopontin. J Cell Physiol. 2004 Jan; 198(1):155-67. PMID: 14584055.
    Citations: 67     Fields:    Translation:AnimalsCells
  66. Bourassa B, Monaghan S, Rittling SR. Impaired anti-tumor cytotoxicity of macrophages from osteopontin-deficient mice. Cell Immunol. 2004 Jan; 227(1):1-11. PMID: 15051510.
    Citations: 13     Fields:    Translation:AnimalsCells
  67. Morinobu M, Ishijima M, Rittling SR, Tsuji K, Yamamoto H, Nifuji A, Denhardt DT, Noda M. Osteopontin expression in osteoblasts and osteocytes during bone formation under mechanical stress in the calvarial suture in vivo. J Bone Miner Res. 2003 Sep; 18(9):1706-15. PMID: 12968681.
    Citations: 47     Fields:    Translation:AnimalsCells
  68. Matsui Y, Rittling SR, Okamoto H, Inobe M, Jia N, Shimizu T, Akino M, Sugawara T, Morimoto J, Kimura C, Kon S, Denhardt D, Kitabatake A, Uede T. Osteopontin deficiency attenuates atherosclerosis in female apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2003 Jun 01; 23(6):1029-34. PMID: 12730087.
    Citations: 56     Fields:    Translation:Animals
  69. Kitahara K, Ishijima M, Rittling SR, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, Noda M. Osteopontin deficiency induces parathyroid hormone enhancement of cortical bone formation. Endocrinology. 2003 May; 144(5):2132-40. PMID: 12697722.
    Citations: 16     Fields:    Translation:AnimalsCells
  70. Chellaiah MA, Biswas RS, Rittling SR, Denhardt DT, Hruska KA. Rho-dependent Rho kinase activation increases CD44 surface expression and bone resorption in osteoclasts. J Biol Chem. 2003 Aug 01; 278(31):29086-97. PMID: 12730217.
    Citations: 26     Fields:    Translation:AnimalsCells
  71. Denhardt DT, Mistretta D, Chambers AF, Krishna S, Porter JF, Raghuram S, Rittling SR. Transcriptional regulation of osteopontin and the metastatic phenotype: evidence for a Ras-activated enhancer in the human OPN promoter. Clin Exp Metastasis. 2003; 20(1):77-84. PMID: 12650610.
    Citations: 35     Fields:    Translation:HumansAnimalsCells
  72. Chen Y, Rittling SR. Novel murine mammary epithelial cell lines that form osteolytic bone metastases: effect of strain background on tumor homing. Clin Exp Metastasis. 2003; 20(2):111-20. PMID: 12705632.
    Citations: 13     Fields:    Translation:HumansAnimalsCells
  73. Chellaiah MA, Kizer N, Biswas R, Alvarez U, Strauss-Schoenberger J, Rifas L, Rittling SR, Denhardt DT, Hruska KA. Osteopontin deficiency produces osteoclast dysfunction due to reduced CD44 surface expression. Mol Biol Cell. 2003 Jan; 14(1):173-89. PMID: 12529435; PMCID: PMC140236.
    Citations: 74     Fields:    Translation:AnimalsCells
  74. Suzuki K, Zhu B, Rittling SR, Denhardt DT, Goldberg HA, McCulloch CA, Sodek J. Colocalization of intracellular osteopontin with CD44 is associated with migration, cell fusion, and resorption in osteoclasts. J Bone Miner Res. 2002 Aug; 17(8):1486-97. PMID: 12162503.
    Citations: 53     Fields:    Translation:AnimalsCells
  75. Yumoto K, Ishijima M, Rittling SR, Tsuji K, Tsuchiya Y, Kon S, Nifuji A, Uede T, Denhardt DT, Noda M. Osteopontin deficiency protects joints against destruction in anti-type II collagen antibody-induced arthritis in mice. Proc Natl Acad Sci U S A. 2002 Apr 02; 99(7):4556-61. PMID: 11930008; PMCID: PMC123686.
    Citations: 62     Fields:    Translation:AnimalsCells
  76. Ishijima M, Tsuji K, Rittling SR, Yamashita T, Kurosawa H, Denhardt DT, Nifuji A, Noda M. Resistance to unloading-induced three-dimensional bone loss in osteopontin-deficient mice. J Bone Miner Res. 2002 Apr; 17(4):661-7. PMID: 11918223.
    Citations: 27     Fields:    Translation:Animals
  77. Potter MR, Rittling SR, Denhardt DT, Roper RJ, Weis JH, Teuscher C, Weis JJ. Role of osteopontin in murine Lyme arthritis and host defense against Borrelia burgdorferi. Infect Immun. 2002 Mar; 70(3):1372-81. PMID: 11854223.
    Citations: 8     Fields:    Translation:AnimalsCells
  78. Rittling SR, Chen Y, Feng F, Wu Y. Tumor-derived osteopontin is soluble, not matrix associated. J Biol Chem. 2002 Mar 15; 277(11):9175-82. PMID: 11741994.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
  79. Chabas D, Baranzini SE, Mitchell D, Bernard CC, Rittling SR, Denhardt DT, Sobel RA, Lock C, Karpuj M, Pedotti R, Heller R, Oksenberg JR, Steinman L. The influence of the proinflammatory cytokine, osteopontin, on autoimmune demyelinating disease. Science. 2001 Nov 23; 294(5547):1731-5. PMID: 11721059.
    Citations: 271     Fields:    Translation:HumansAnimalsCells
  80. Nemoto H, Rittling SR, Yoshitake H, Furuya K, Amagasa T, Tsuji K, Nifuji A, Denhardt DT, Noda M. Osteopontin deficiency reduces experimental tumor cell metastasis to bone and soft tissues. J Bone Miner Res. 2001 Apr; 16(4):652-9. PMID: 11315992.
    Citations: 39     Fields:    Translation:Animals
  81. Asou Y, Rittling SR, Yoshitake H, Tsuji K, Shinomiya K, Nifuji A, Denhardt DT, Noda M. Osteopontin facilitates angiogenesis, accumulation of osteoclasts, and resorption in ectopic bone. Endocrinology. 2001 Mar; 142(3):1325-32. PMID: 11181551.
    Citations: 43     Fields:    Translation:AnimalsCells
  82. Ishijima M, Rittling SR, Yamashita T, Tsuji K, Kurosawa H, Nifuji A, Denhardt DT, Noda M. Enhancement of osteoclastic bone resorption and suppression of osteoblastic bone formation in response to reduced mechanical stress do not occur in the absence of osteopontin. J Exp Med. 2001 Feb 05; 193(3):399-404. PMID: 11157060; PMCID: PMC2195919.
    Citations: 76     Fields:    Translation:AnimalsCells
  83. Ihara H, Denhardt DT, Furuya K, Yamashita T, Muguruma Y, Tsuji K, Hruska KA, Higashio K, Enomoto S, Nifuji A, Rittling SR, Noda M. Parathyroid hormone-induced bone resorption does not occur in the absence of osteopontin. J Biol Chem. 2001 Apr 20; 276(16):13065-71. PMID: 11278791.
    Citations: 24     Fields:    Translation:AnimalsCells
  84. Denhardt DT, Giachelli CM, Rittling SR. Role of osteopontin in cellular signaling and toxicant injury. Annu Rev Pharmacol Toxicol. 2001; 41:723-49. PMID: 11264474.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  85. Feng F, Rittling SR. Mammary tumor development in MMTV-c-myc/MMTV-v-Ha-ras transgenic mice is unaffected by osteopontin deficiency. Breast Cancer Res Treat. 2000 Sep; 63(1):71-9. PMID: 11079161.
    Citations: 10     Fields:    Translation:Animals
  86. Bonvini JM, Schatzmann U, Beck-Schimmer B, Sun LK, Rittling SR, Denhardt DT, LE Hir M, Wüthrich RP. Lack of in vivo function of osteopontin in experimental anti-GBM nephritis. J Am Soc Nephrol. 2000 Sep; 11(9):1647-1655. PMID: 10966489.
    Citations: 7     Fields:    Translation:Animals
  87. Wu Y, Denhardt DT, Rittling SR. Osteopontin is required for full expression of the transformed phenotype by the ras oncogene. Br J Cancer. 2000 Jul; 83(2):156-63. PMID: 10901364; PMCID: PMC2363489.
    Citations: 23     Fields:    Translation:AnimalsCells
  88. Ashkar S, Weber GF, Panoutsakopoulou V, Sanchirico ME, Jansson M, Zawaideh S, Rittling SR, Denhardt DT, Glimcher MJ, Cantor H. Eta-1 (osteopontin): an early component of type-1 (cell-mediated) immunity. Science. 2000 Feb 04; 287(5454):860-4. PMID: 10657301.
    Citations: 325     Fields:    Translation:AnimalsCells
  89. Yoshitake H, Rittling SR, Denhardt DT, Noda M. Osteopontin-deficient mice are resistant to ovariectomy-induced bone resorption. Proc Natl Acad Sci U S A. 1999 Jul 06; 96(14):8156-60. PMID: 10393964; PMCID: PMC22204.
    Citations: 93     Fields:    Translation:HumansAnimals
  90. Noiri E, Dickman K, Miller F, Romanov G, Romanov VI, Shaw R, Chambers AF, Rittling SR, Denhardt DT, Goligorsky MS. Reduced tolerance to acute renal ischemia in mice with a targeted disruption of the osteopontin gene. Kidney Int. 1999 Jul; 56(1):74-82. PMID: 10411681.
    Citations: 12     Fields:    Translation:AnimalsCells
  91. Rittling SR, Denhardt DT. Osteopontin function in pathology: lessons from osteopontin-deficient mice. Exp Nephrol. 1999 Mar-Apr; 7(2):103-13. PMID: 10213864.
    Citations: 52     Fields:    Translation:HumansAnimals
  92. Rittling SR, Feng F. Detection of mouse osteopontin by western blotting. Biochem Biophys Res Commun. 1998 Sep 18; 250(2):287-92. PMID: 9753622.
    Citations: 13     Fields:    Translation:HumansAnimals
  93. Rittling SR, Matsumoto HN, McKee MD, Nanci A, An XR, Novick KE, Kowalski AJ, Noda M, Denhardt DT. Mice lacking osteopontin show normal development and bone structure but display altered osteoclast formation in vitro. J Bone Miner Res. 1998 Jul; 13(7):1101-11. PMID: 9661074.
    Citations: 138     Fields:    Translation:AnimalsCells
  94. Rittling SR, Novick KE. Osteopontin expression in mammary gland development and tumorigenesis. Cell Growth Differ. 1997 Oct; 8(10):1061-9. PMID: 9342184.
    Citations: 25     Fields:    Translation:Animals
  95. Rittling SR. Clonal nature of spontaneously immortalized 3T3 cells. Exp Cell Res. 1996 Nov 25; 229(1):7-13. PMID: 8940243.
    Citations: 6     Fields:    Translation:AnimalsCells
  96. Malyankar UM, Rittling SR, Denhardt DT. Instability of endogenous MRP/proliferin transcripts in the nucleus of mouse embryo fibroblasts contrasts with their stability when produced during transient transfections. J Cell Biochem. 1996 Feb; 60(2):198-210. PMID: 8655630.
    Citations:    Fields:    Translation:AnimalsCells
  97. Malyankar UM, Rittling SR, Connor A, Denhardt DT. The mitogen-regulated protein/proliferin transcript is degraded in primary mouse embryo fibroblast but not 3T3 nuclei: altered RNA processing correlates with immortalization. Proc Natl Acad Sci U S A. 1994 Jan 04; 91(1):335-9. PMID: 8278389; PMCID: PMC42942.
    Citations: 5     Fields:    Translation:AnimalsCells
  98. Brooks-Frederich KM, Cianciarulo FL, Rittling SR, Cristofalo VJ. Cell cycle-dependent regulation of Ca2+ in young and senescent WI-38 cells. Exp Cell Res. 1993 Apr; 205(2):412-5. PMID: 8482347.
    Citations: 3     Fields:    Translation:HumansCells
  99. Rittling SR, Denhardt DT. p53 mutations in spontaneously immortalized 3T12 but not 3T3 mouse embryo cells. Oncogene. 1992 May; 7(5):935-42. PMID: 1349164.
    Citations: 10     Fields:    Translation:AnimalsCells
  100. Rittling SR, Coutinho L, Amram T, Kolbe M. AP-1/jun binding sites mediate serum inducibility of the human vimentin promoter. Nucleic Acids Res. 1989 Feb 25; 17(4):1619-33. PMID: 2922288; PMCID: PMC336896.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  101. Rittling SR, Baserga R. Functional analysis and growth factor regulation of the human vimentin promoter. Mol Cell Biol. 1987 Nov; 7(11):3908-15. PMID: 3431546.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  102. Rittling SR, Baserga R. Regulatory mechanisms in the expression of cell cycle dependent genes. Anticancer Res. 1987 Jul-Aug; 7(4A):541-52. PMID: 3310845.
    Citations:    Fields:    Translation:HumansAnimals
  103. Ferrari S, Battini R, Kaczmarek L, Rittling S, Calabretta B, de Riel JK, Philiponis V, Wei JF, Baserga R. Coding sequence and growth regulation of the human vimentin gene. Mol Cell Biol. 1986 Nov; 6(11):3614-20. PMID: 3467175.
    Citations: 51     Fields:    Translation:HumansAnimalsCells
  104. Gibson CW, Rittling SR, Hirschhorn RR, Kaczmarek L, Calabretta B, Stiles CD, Baserga R. Cell cycle dependent genes inducible by different mitogens in cells from different species. Mol Cell Biochem. 1986 Jun; 71(1):61-9. PMID: 3755218.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  105. Rittling SR, Brooks KM, Cristofalo VJ, Baserga R. Expression of cell cycle-dependent genes in young and senescent WI-38 fibroblasts. Proc Natl Acad Sci U S A. 1986 May; 83(10):3316-20. PMID: 3458185; PMCID: PMC323504.
    Citations: 42     Fields:    Translation:HumansCells
  106. Rittling SR, Gibson CW, Ferrari S, Baserga R. The effect of cycloheximide on the expression of cell cycle dependent genes. Biochem Biophys Res Commun. 1985 Oct 15; 132(1):327-35. PMID: 4062932.
    Citations: 10     Fields:    Translation:AnimalsCells
  107. Liu HT, Gibson CW, Hirschhorn RR, Rittling S, Baserga R, Mercer WE. Expression of thymidine kinase and dihydrofolate reductase genes in mammalian ts mutants of the cell cycle. J Biol Chem. 1985 Mar 25; 260(6):3269-74. PMID: 3838311.
    Citations: 31     Fields:    Translation:AnimalsCells
  108. Rittling SR, Woodworth RC. The synthesis and turnover of ferritin in rat L-6 cells. Rates and response to iron, actinomycin D, and desferrioxamine. J Biol Chem. 1984 May 10; 259(9):5561-6. PMID: 6715360.
    Citations: 8     Fields:    Translation:AnimalsCells
  109. Low RB, Stirewalt WS, Rittling SR, Woodworth RC. Amino acid pools in cultured muscle cells. J Cell Biochem. 1984; 25(3):123-9. PMID: 6566676.
    Citations: 2     Fields:    Translation:AnimalsCells
  110. Rittling SR, Woodworth RC. Ferritin synthesis in rat L-6 cells: response to iron challenge. Arch Biochem Biophys. 1983 Aug; 225(1):390-7. PMID: 6614930.
    Citations:    Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.