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Martha Murray, M.D.


A Histologic Study of Enhanced ACL Repair
Summer, 06/02/08 - 08/29/08

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R34AR066631 (MURRAY, MARTHA M) Mar 1, 2017 - Feb 28, 2019
    Planning A Clinical Trial of Bio-enhanced ACL Repair versus ACL Reconstruction
    Role: Principal Investigator
  2. R01AR065462 (FLEMING, BRADEN C) Sep 16, 2014 - Aug 31, 2017
    Non-invasive assessment of ligament healing in vivo
    Role: Co-Principal Investigator
  3. R01AR056834 (FLEMING, BRADEN C) Feb 1, 2009 - Aug 31, 2018
    Bio-enhanced ACL Repair as a Modular of Post-traumatic Osteoarthritis
    Role: Co-Principal Investigator
  4. R01AR052772 (MURRAY, MARTHA M) Sep 7, 2007 - Dec 30, 2011
    A Novel Mechanism for Intra-articular Nonunion
    Role: Principal Investigator
  5. R01AR054099 (MURRAY, MARTHA M) Jul 1, 2006 - May 31, 2014
    The Effect of Age on Functional ACL Healing
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Fleming BC, Murray MM. Transcriptional profiling of synovium in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Feb 20. PMID: 29460983.
    View in: PubMed
  2. Beveridge JE, Machan JT, Walsh EG, Kiapour AM, Karamchedu NP, Chin KE, Proffen BL, Sieker JT, Murray MM, Fleming BC. Magnetic resonance measurements of tissue quantity and quality using T2 * relaxometry predict temporal changes in the biomechanical properties of the healing ACL. J Orthop Res. 2018 Jun; 36(6):1701-1709. PMID: 29227559.
    View in: PubMed
  3. Kiapour AM, Fleming BC, Murray MM. Structural and Anatomic Restoration of the Anterior Cruciate Ligament Is Associated With Less Cartilage Damage 1 Year After Surgery: Healing Ligament Properties Affect Cartilage Damage. Orthop J Sports Med. 2017 Aug; 5(8):2325967117723886. PMID: 28875154.
    View in: PubMed
  4. Sieker JT, Proffen BL, Waller KA, Chin KE, Karamchedu NP, Akelman MR, Perrone GS, Kiapour AM, Konrad J, Murray MM, Fleming BC. Transcriptional profiling of articular cartilage in a porcine model of early post-traumatic osteoarthritis. J Orthop Res. 2018 Jan; 36(1):318-329. PMID: 28671352.
    View in: PubMed
  5. Perrone GS, Proffen BL, Kiapour AM, Sieker JT, Fleming BC, Murray MM. Bench-to-bedside: Bridge-enhanced anterior cruciate ligament repair. J Orthop Res. 2017 Dec; 35(12):2606-2612. PMID: 28608618.
    View in: PubMed
  6. Beveridge JE, Walsh EG, Murray MM, Fleming BC. Sensitivity of ACL volume and T2* relaxation time to magnetic resonance imaging scan conditions. J Biomech. 2017 May 03; 56:117-121. PMID: 28359570.
    View in: PubMed
  7. Murray MM, Flutie BM, Kalish LA, Ecklund K, Fleming BC, Proffen BL, Micheli LJ. The Bridge-Enhanced Anterior Cruciate Ligament Repair (BEAR) Procedure: An Early Feasibility Cohort Study. Orthop J Sports Med. 2016 Nov; 4(11):2325967116672176. PMID: 27900338.
    View in: PubMed
  8. Chin KE, Karamchedu NP, Patel TK, Badger GJ, Akelman MR, Moore DC, Proffen BL, Murray MM, Fleming BC. Comparison of micro-CT post-processing methods for evaluating the trabecular bone volume fraction in a rat ACL-transection model. J Biomech. 2016 10 03; 49(14):3559-3563. PMID: 27594677.
    View in: PubMed
  9. Sieker JT, Ayturk UM, Proffen BL, Weissenberger MH, Kiapour AM, Murray MM. Immediate Administration of Intraarticular Triamcinolone Acetonide After Joint Injury Modulates Molecular Outcomes Associated With Early Synovitis. Arthritis Rheumatol. 2016 07; 68(7):1637-47. PMID: 26866935; PMCID: PMC4982368 [Available on 07/01/17].
  10. Proffen BL, Sieker JT, Murray MM, Akelman MR, Chin KE, Perrone GS, Patel TK, Fleming BC. Extracellular matrix-blood composite injection reduces post-traumatic osteoarthritis after anterior cruciate ligament injury in the rat. J Orthop Res. 2016 06; 34(6):995-1003. PMID: 26629963; PMCID: PMC4882220 [Available on 06/01/17].
  11. Kelly BA, Proffen BL, Haslauer CM, Murray MM. Platelets and plasma stimulate sheep rotator cuff tendon tenocytes when cultured in an extracellular matrix scaffold. J Orthop Res. 2016 Apr; 34(4):623-9. PMID: 26419602; PMCID: PMC4814346 [Available on 04/01/17].
  12. Kiapour AM, Fleming BC, Murray MM. Biomechanical Outcomes of Bridge-enhanced Anterior Cruciate Ligament Repair Are Influenced by Sex in a Preclinical Model. Clin Orthop Relat Res. 2015 Aug; 473(8):2599-608. PMID: 25742916; PMCID: PMC4488214.
  13. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Murray MM. Effect of low-temperature ethylene oxide and electron beam sterilization on the in vitro and in vivo function of reconstituted extracellular matrix-derived scaffolds. J Biomater Appl. 2015 Oct; 30(4):435-49. PMID: 26088294; PMCID: PMC4670802 [Available on 10/01/16].
  14. Kiapour AM, Fleming BC, Proffen BL, Murray MM. Sex Influences the Biomechanical Outcomes of Anterior Cruciate Ligament Reconstruction in a Preclinical Large Animal Model. Am J Sports Med. 2015 Jul; 43(7):1623-31. PMID: 25939612; PMCID: PMC4490080.
  15. Proffen BL, Perrone GS, Fleming BC, Sieker JT, Kramer J, Hawes ML, Badger GJ, Murray MM. Electron beam sterilization does not have a detrimental effect on the ability of extracellular matrix scaffolds to support in vivo ligament healing. J Orthop Res. 2015 Jul; 33(7):1015-23. PMID: 25676876; PMCID: PMC4517185.
  16. Biercevicz AM, Proffen BL, Murray MM, Walsh EG, Fleming BC. T2* relaxometry and volume predict semi-quantitative histological scoring of an ACL bridge-enhanced primary repair in a porcine model. J Orthop Res. 2015 Aug; 33(8):1180-7. PMID: 25764143; PMCID: PMC4497917.
  17. Proffen BL, Perrone GS, Roberts G, Murray MM. Bridge-enhanced ACL repair: A review of the science and the pathway through FDA investigational device approval. Ann Biomed Eng. 2015 Mar; 43(3):805-18. PMID: 25631206; PMCID: PMC4799652.
  18. Proffen BL, Sieker JT, Murray MM. Bio-enhanced repair of the anterior cruciate ligament. Arthroscopy. 2015 May; 31(5):990-7. PMID: 25595694; PMCID: PMC4426066.
  19. Proffen BL, Vavken P, Haslauer CM, Fleming BC, Harris CE, Machan JT, Murray MM. Addition of autologous mesenchymal stem cells to whole blood for bioenhanced ACL repair has no benefit in the porcine model. Am J Sports Med. 2015 Feb; 43(2):320-30. PMID: 25549633; PMCID: PMC4511104.
  20. Haslauer CM, Proffen BL, Johnson VM, Hill A, Murray MM. Gene expression of catabolic inflammatory cytokines peak before anabolic inflammatory cytokines after ACL injury in a preclinical model. J Inflamm (Lond). 2014; 11(1):34. PMID: 25400511; PMCID: PMC4232656.
  21. Kiapour AM, Shalvoy MR, Murray MM, Fleming BC. Validation of porcine knee as a sex-specific model to study human anterior cruciate ligament disorders. Clin Orthop Relat Res. 2015 Feb; 473(2):639-50. PMID: 25269532; PMCID: PMC4294889.
  22. Bennike T, Ayturk U, Haslauer CM, Froehlich JW, Proffen BL, Barnaby O, Birkelund S, Murray MM, Warman ML, Stensballe A, Steen H. A normative study of the synovial fluid proteome from healthy porcine knee joints. J Proteome Res. 2014 Oct 03; 13(10):4377-87. PMID: 25160569; PMCID: PMC4184458.
  23. Hutchinson ID, Rodeo SA, Perrone GS, Murray MM. Can platelet-rich plasma enhance anterior cruciate ligament and meniscal repair? J Knee Surg. 2015 Feb; 28(1):19-28. PMID: 25101873.
    View in: PubMed
  24. Proffen BL, Nielson JH, Zurakowski D, Micheli LJ, Curtis C, Murray MM. The Effect of Perioperative Ketorolac on the Clinical Failure Rate of Meniscal Repair. Orthop J Sports Med. 2014 May 01; 2(5). PMID: 25401118.
    View in: PubMed
  25. Biercevicz AM, Walsh EG, Murray MM, Akelman MR, Fleming BC. Improving the clinical efficiency of T2(*) mapping of ligament integrity. J Biomech. 2014 Jul 18; 47(10):2522-5. PMID: 24792580; PMCID: PMC4057958.
  26. Fleming BC, Proffen BL, Vavken P, Shalvoy MR, Machan JT, Murray MM. Increased platelet concentration does not improve functional graft healing in bio-enhanced ACL reconstruction. Knee Surg Sports Traumatol Arthrosc. 2015 Apr; 23(4):1161-70. PMID: 24633008; PMCID: PMC4167989.
  27. Kiapour AM, Murray MM. Basic science of anterior cruciate ligament injury and repair. Bone Joint Res. 2014; 3(2):20-31. PMID: 24497504; PMCID: PMC3922117.
  28. Haslauer CM, Proffen BL, Johnson VM, Murray MM. Expression of modulators of extracellular matrix structure after anterior cruciate ligament injury. Wound Repair Regen. 2014 Jan-Feb; 22(1):103-10. PMID: 24393158; PMCID: PMC3888089.
  29. Biercevicz AM, Murray MM, Walsh EG, Miranda DL, Machan JT, Fleming BC. T2 * MR relaxometry and ligament volume are associated with the structural properties of the healing ACL. J Orthop Res. 2014 Apr; 32(4):492-9. PMID: 24338640; PMCID: PMC3946219.
  30. Proffen BL, Fleming BC, Murray MM. Histologic Predictors of Maximum Failure Loads Differ between the Healing ACL and ACL Grafts after 6 and 12 Months In Vivo. Orthop J Sports Med. 2013 Nov; 1(6). PMID: 25343145.
    View in: PubMed
  31. Yoshida R, Cheng M, Murray MM. Increasing platelet concentration in platelet-rich plasma inhibits anterior cruciate ligament cell function in three-dimensional culture. J Orthop Res. 2014 Feb; 32(2):291-5. PMID: 24122902; PMCID: PMC3945668.
  32. Haslauer CM, Elsaid KA, Fleming BC, Proffen BL, Johnson VM, Murray MM. Loss of extracellular matrix from articular cartilage is mediated by the synovium and ligament after anterior cruciate ligament injury. Osteoarthritis Cartilage. 2013 Dec; 21(12):1950-7. PMID: 24036379; PMCID: PMC3917322.
  33. Rodeo SA, Boden SD, Murray MM, Einhorn TA. 2011 AOA Symposium: Tissue Engineering and Tissue Regeneration: AOA critical issues. J Bone Joint Surg Am. 2013 Aug 07; 95(15):e109. PMID: 23925754; PMCID: PMC3748991.
  34. Murray MM, Fleming BC. Use of a bioactive scaffold to stimulate anterior cruciate ligament healing also minimizes posttraumatic osteoarthritis after surgery. Am J Sports Med. 2013 Aug; 41(8):1762-70. PMID: 23857883; PMCID: PMC3735821.
  35. Murray MM, Fleming BC. Biology of anterior cruciate ligament injury and repair: Kappa delta ann doner vaughn award paper 2013. J Orthop Res. 2013 Oct; 31(10):1501-6. PMID: 23818453; PMCID: PMC3750083.
  36. Biercevicz AM, Miranda DL, Machan JT, Murray MM, Fleming BC. In Situ, noninvasive, T2*-weighted MRI-derived parameters predict ex vivo structural properties of an anterior cruciate ligament reconstruction or bioenhanced primary repair in a porcine model. Am J Sports Med. 2013 Mar; 41(3):560-6. PMID: 23348076; PMCID: PMC3593999.
  37. Vavken P, Proffen B, Peterson C, Fleming BC, Machan JT, Murray MM. Effects of suture choice on biomechanics and physeal status after bioenhanced anterior cruciate ligament repair in skeletally immature patients: a large-animal study. Arthroscopy. 2013 Jan; 29(1):122-32. PMID: 23200845; PMCID: PMC3644616.
  38. Proffen BL, Haslauer CM, Harris CE, Murray MM. Mesenchymal stem cells from the retropatellar fat pad and peripheral blood stimulate ACL fibroblast migration, proliferation, and collagen gene expression. Connect Tissue Res. 2013; 54(1):14-21. PMID: 22839298; PMCID: PMC3836054.
  39. Yoshida R, Murray MM. Peripheral blood mononuclear cells enhance the anabolic effects of platelet-rich plasma on anterior cruciate ligament fibroblasts. J Orthop Res. 2013 Jan; 31(1):29-34. PMID: 22767425; PMCID: PMC3469725.
  40. Magarian EM, Vavken P, Connolly SA, Mastrangelo AN, Murray MM. Safety of intra-articular use of atelocollagen for enhanced tissue repair. Open Orthop J. 2012; 6:231-8. PMID: 22802918.
    View in: PubMed
  41. Vavken P, Fleming BC, Mastrangelo AN, Machan JT, Murray MM. Biomechanical outcomes after bioenhanced anterior cruciate ligament repair and anterior cruciate ligament reconstruction are equal in a porcine model. Arthroscopy. 2012 May; 28(5):672-80. PMID: 22261137; PMCID: PMC3340462.
  42. Fleming BC, Vajapeyam S, Connolly SA, Magarian EM, Murray MM. The use of magnetic resonance imaging to predict ACL graft structural properties. J Biomech. 2011 Nov 10; 44(16):2843-6. PMID: 21962290; PMCID: PMC3208804.
  43. Yoshida R, Vavken P, Murray MM. Decellularization of bovine anterior cruciate ligament tissues minimizes immunogenic reactions to alpha-gal epitopes by human peripheral blood mononuclear cells. Knee. 2012 Oct; 19(5):672-5. PMID: 21925883; PMCID: PMC3243811.
  44. Vavken P, Sadoghi P, Murray MM. The effect of platelet concentrates on graft maturation and graft-bone interface healing in anterior cruciate ligament reconstruction in human patients: a systematic review of controlled trials. Arthroscopy. 2011 Nov; 27(11):1573-83. PMID: 21862277; PMCID: PMC3206130.
  45. Palmer M, Stanford E, Murray MM. The Effect of Synovial Fluid Enzymes on the Biodegradability of Collagen and Fibrin Clots. Materials (Basel). 2011 Aug 20; 4(8):1469-1482. PMID: 21949586.
    View in: PubMed
  46. Proffen BL, McElfresh M, Fleming BC, Murray MM. A comparative anatomical study of the human knee and six animal species. Knee. 2012 Aug; 19(4):493-9. PMID: 21852139; PMCID: PMC3236814.
  47. Haus BM, Mastrangelo AN, Murray MM. Effect of anterior cruciate healing on the uninjured ligament insertion site. J Orthop Res. 2012 Jan; 30(1):86-94. PMID: 21748793; PMCID: PMC3220740.
  48. Cheng M, Johnson VM, Murray MM. Effects of age and platelet-rich plasma on ACL cell viability and collagen gene expression. J Orthop Res. 2012 Jan; 30(1):79-85. PMID: 21748791; PMCID: PMC3202019.
  49. Vavken P, Murray MM. Treating anterior cruciate ligament tears in skeletally immature patients. Arthroscopy. 2011 May; 27(5):704-16. PMID: 21552340; PMCID: PMC3088307.
  50. Harrison SL, Vavken P, Murray MM. Erythrocytes inhibit ligament fibroblast proliferation in a collagen scaffold. J Orthop Res. 2011 Sep; 29(9):1361-6. PMID: 21445984; PMCID: PMC3176723.
  51. Harrison S, Vavken P, Kevy S, Jacobson M, Zurakowski D, Murray MM. Platelet activation by collagen provides sustained release of anabolic cytokines. Am J Sports Med. 2011 Apr; 39(4):729-34. PMID: 21398575; PMCID: PMC3176726.
  52. Steinert AF, Kunz M, Prager P, Barthel T, Jakob F, Nöth U, Murray MM, Evans CH, Porter RM. Mesenchymal stem cell characteristics of human anterior cruciate ligament outgrowth cells. Tissue Eng Part A. 2011 May; 17(9-10):1375-88. PMID: 21247268; PMCID: PMC3079172.
  53. Vavken P, Murray MM. The potential for primary repair of the ACL. Sports Med Arthrosc Rev. 2011 Mar; 19(1):44-9. PMID: 21293237; PMCID: PMC3073665.
  54. Vavken P, Saad FA, Fleming BC, Murray MM. VEGF receptor mRNA expression by ACL fibroblasts is associated with functional healing of the ACL. Knee Surg Sports Traumatol Arthrosc. 2011 Oct; 19(10):1675-82. PMID: 21331648; PMCID: PMC3210695.
  55. Mastrangelo AN, Vavken P, Fleming BC, Harrison SL, Murray MM. Reduced platelet concentration does not harm PRP effectiveness for ACL repair in a porcine in vivo model. J Orthop Res. 2011 Jul; 29(7):1002-7. PMID: 21337615; PMCID: PMC3094496.
  56. Magarian EM, Fleming BC, Harrison SL, Mastrangelo AN, Badger GJ, Murray MM. Delay of 2 or 6 weeks adversely affects the functional outcome of augmented primary repair of the porcine anterior cruciate ligament. Am J Sports Med. 2010 Dec; 38(12):2528-34. PMID: 20855556; PMCID: PMC2996471.
  57. Murray MM, Magarian EM, Harrison SL, Mastrangelo AN, Zurakowski D, Fleming BC. The effect of skeletal maturity on functional healing of the anterior cruciate ligament. J Bone Joint Surg Am. 2010 Sep 01; 92(11):2039-49. PMID: 20810854; PMCID: PMC2924734.
  58. Magarian EM, Vavken P, Murray MM. Human anterior cruciate ligament fibroblasts from immature patients have a stronger in vitro response to platelet concentrates than those from mature individuals. Knee. 2011 Aug; 18(4):247-51. PMID: 20728363; PMCID: PMC2991424.
  59. Vavken P, Saad FA, Murray MM. Age dependence of expression of growth factor receptors in porcine ACL fibroblasts. J Orthop Res. 2010 Aug; 28(8):1107-12. PMID: 20186834; PMCID: PMC2892023.
  60. Mastrangelo AN, Haus BM, Vavken P, Palmer MP, Machan JT, Murray MM. Immature animals have higher cellular density in the healing anterior cruciate ligament than adolescent or adult animals. J Orthop Res. 2010 Aug; 28(8):1100-6. PMID: 20127960; PMCID: PMC2892020.
  61. Haddad-Weber M, Prager P, Kunz M, Seefried L, Jakob F, Murray MM, Evans CH, Nöth U, Steinert AF. BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells. Cytotherapy. 2010 Jul; 12(4):505-13. PMID: 20334610.
    View in: PubMed
  62. Murray MM, Magarian E, Zurakowski D, Fleming BC. Bone-to-bone fixation enhances functional healing of the porcine anterior cruciate ligament using a collagen-platelet composite. Arthroscopy. 2010 Sep; 26(9 Suppl):S49-57. PMID: 20810092; PMCID: PMC2936961.
  63. Fleming BC, Magarian EM, Harrison SL, Paller DJ, Murray MM. Collagen scaffold supplementation does not improve the functional properties of the repaired anterior cruciate ligament. J Orthop Res. 2010 Jun; 28(6):703-9. PMID: 20058276; PMCID: PMC2858260.
  64. Cheng M, Wang H, Yoshida R, Murray MM. Platelets and plasma proteins are both required to stimulate collagen gene expression by anterior cruciate ligament cells in three-dimensional culture. Tissue Eng Part A. 2010 May; 16(5):1479-89. PMID: 19958169; PMCID: PMC2952126.
  65. Mastrangelo AN, Magarian EM, Palmer MP, Vavken P, Murray MM. The effect of skeletal maturity on the regenerative function of intrinsic ACL cells. J Orthop Res. 2010 May; 28(5):644-51. PMID: 19890988; PMCID: PMC2845722.
  66. Abreu EL, Palmer MP, Murray MM. Collagen density significantly affects the functional properties of an engineered provisional scaffold. J Biomed Mater Res A. 2010 Apr; 93(1):150-7. PMID: 19536834; PMCID: PMC3069635.
  67. Vavken P, Murray MM. Translational studies in anterior cruciate ligament repair. Tissue Eng Part B Rev. 2010 Feb; 16(1):5-11. PMID: 20143926.
    View in: PubMed
  68. Vavken P, Joshi SM, Murray MM. Fibrin concentration affects ACL fibroblast proliferation and collagen synthesis. Knee. 2011 Jan; 18(1):42-6. PMID: 20080411; PMCID: PMC2891311.
  69. Vavken P, Joshi S, Murray MM. TRITON-X is most effective among three decellularization agents for ACL tissue engineering. J Orthop Res. 2009 Dec; 27(12):1612-8. PMID: 19504590; PMCID: PMC2824567.
  70. Joshi SM, Mastrangelo AN, Magarian EM, Fleming BC, Murray MM. Collagen-platelet composite enhances biomechanical and histologic healing of the porcine anterior cruciate ligament. Am J Sports Med. 2009 Dec; 37(12):2401-10. PMID: 19940313; PMCID: PMC2856313.
  71. Kritsaneepaiboon S, Shah R, Murray MM, Kleinman PK. Posterior periosteal disruption in Salter-Harris Type II fractures of the distal femur: evidence for a hyperextension mechanism. AJR Am J Roentgenol. 2009 Dec; 193(6):W540-5. PMID: 19933629.
    View in: PubMed
  72. Palmer MP, Abreu EL, Mastrangelo A, Murray MM. Injection temperature significantly affects in vitro and in vivo performance of collagen-platelet scaffolds. J Orthop Res. 2009 Jul; 27(7):964-71. PMID: 19030174; PMCID: PMC2735874.
  73. Abreu EL, Palmer MP, Murray MM. Storage conditions do not have detrimental effect on allograft collagen or scaffold performance. Cell Tissue Bank. 2009 Nov; 10(4):333-40. PMID: 19507051.
    View in: PubMed
  74. Spindler KP, Murray MM, Carey JL, Zurakowski D, Fleming BC. The use of platelets to affect functional healing of an anterior cruciate ligament (ACL) autograft in a caprine ACL reconstruction model. J Orthop Res. 2009 May; 27(5):631-8. PMID: 19009602; PMCID: PMC2752673.
  75. Murray MM, Palmer M, Abreu E, Spindler KP, Zurakowski D, Fleming BC. Platelet-rich plasma alone is not sufficient to enhance suture repair of the ACL in skeletally immature animals: an in vivo study. J Orthop Res. 2009 May; 27(5):639-45. PMID: 18991345; PMCID: PMC2824566.
  76. Pearse RV, Esshaki D, Tabin CJ, Murray MM. Genome-wide expression analysis of intra- and extraarticular connective tissue. J Orthop Res. 2009 Apr; 27(4):427-34. PMID: 18972360; PMCID: PMC2856484.
  77. Fleming BC, Spindler KP, Palmer MP, Magarian EM, Murray MM. Collagen-platelet composites improve the biomechanical properties of healing anterior cruciate ligament grafts in a porcine model. Am J Sports Med. 2009 Aug; 37(8):1554-63. PMID: 19336614; PMCID: PMC2796133.
  78. Murray MM. Current status and potential of primary ACL repair. Clin Sports Med. 2009 Jan; 28(1):51-61. PMID: 19064165; PMCID: PMC2642924.
  79. Fleming BC, Carey JL, Spindler KP, Murray MM. Can suture repair of ACL transection restore normal anteroposterior laxity of the knee? An ex vivo study. J Orthop Res. 2008 Nov; 26(11):1500-5. PMID: 18528857; PMCID: PMC2790602.
  80. Jacobson M, Fufa D, Abreu EL, Kevy S, Murray MM. Platelets, but not erythrocytes, significantly affect cytokine release and scaffold contraction in a provisional scaffold model. Wound Repair Regen. 2008 May-Jun; 16(3):370-8. PMID: 18471255; PMCID: PMC3580948.
  81. Fufa D, Shealy B, Jacobson M, Kevy S, Murray MM. Activation of platelet-rich plasma using soluble type I collagen. J Oral Maxillofac Surg. 2008 Apr; 66(4):684-90. PMID: 18355591; PMCID: PMC2405953.
  82. Steiner ME, Murray MM, Rodeo SA. Strategies to improve anterior cruciate ligament healing and graft placement. Am J Sports Med. 2008 Jan; 36(1):176-89. PMID: 18166680.
    View in: PubMed
  83. Steinert AF, Weber M, Kunz M, Palmer GD, Nöth U, Evans CH, Murray MM. In situ IGF-1 gene delivery to cells emerging from the injured anterior cruciate ligament. Biomaterials. 2008 Mar; 29(7):904-16. PMID: 18045683.
    View in: PubMed
  84. Murray, M. M., Mankin, H. J., Glowacki, J. The Musculoskeletal System. O’Leary, JP editor. The Physiologic Basis of Surgery. 2007.
  85. Murray MM, Spindler KP, Ballard P, Welch TP, Zurakowski D, Nanney LB. Enhanced histologic repair in a central wound in the anterior cruciate ligament with a collagen-platelet-rich plasma scaffold. J Orthop Res. 2007 Aug; 25(8):1007-17. PMID: 17415785.
    View in: PubMed
  86. Kocher MS, Kasser JR, Waters PM, Bae D, Snyder BD, Hresko MT, Hedequist D, Karlin L, Kim YJ, Murray MM, Millis MB, Emans JB, Dichtel L, Matheney T, Lee BM. Lateral entry compared with medial and lateral entry pin fixation for completely displaced supracondylar humeral fractures in children. A randomized clinical trial. J Bone Joint Surg Am. 2007 Apr; 89(4):706-12. PMID: 17403790.
    View in: PubMed
  87. Fufa D., Shealy B., Jacobson M., Kevy S., Murray MM. Type I Collagen as a Platelet Activator in Platelet-Rich Plasma Hydrogels. 2007.
  88. Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB. Enhanced Histologic Repair in a Central Defect in the Anterior Cruciate Ligament with a Collagen-Platelet Rich Plasma Scaffold. 2007.
  89. Murray, MM., Spindler, K.P., Ballard, P., Welch, T., Nanney, LB. Enhanced Histologic Repair in a Central Defect in the ACL with a Collagen-PRP Scaffold. J Orthop Res. 2007; 25(8):1007-1017.
  90. Duretti Fufa, MD; Blake Shealy; May Jacobson, PhD; Sherwin Kevy, MD; Martha Meaney Murray, MD. Activation of Platelet-Rich Plasma Using Soluble Type I Collagen. Journal of Oral and Maxillofacial Surgery, accepted for publication. 2007.
  91. Murray MM., Spindler KP., Ballard P., Welch T., Nanney LB. Histologic Differences in Healing of Intra-Articular and Extra-Articular Ligament Wounds. 2007.
  92. Murray MM, Spindler KP, Abreu E, Muller JA, Nedder A, Kelly M, Frino J, Zurakowski D, Valenza M, Snyder BD, Connolly SA. Collagen-platelet rich plasma hydrogel enhances primary repair of the porcine anterior cruciate ligament. J Orthop Res. 2007 Jan; 25(1):81-91. PMID: 17031861.
    View in: PubMed
  93. Murray MM., Spindler KP., Abreu E., Muller J., Nedder A., Kelly M., Frino J., Zurakowski D., Valenza M., Snyder BD., Palmer M., Connolly S. Collagen-Platelet Rich Plasma Hydrogel Enhances Primary Repair of the Porcine Anterior Cruciate Ligament. 2007.
  94. Abreu E., Marler J., Murray MM. The Effect of Collagen Concentration on Platelet-Rich Plasma Hydrogels. 2007.
  95. Yeh J., Shealy B., Jacobson M., Sherwin K., Hootnik J., Murray MM. . Effect of Collagen Source on Human ACL Cell Proliferation and Platelet Activation. 2007.
  96. Mahan ST, Murray MM, Woolf AD, Kasser JR. Increased blood lead levels in an adolescent girl from a retained bullet. A case report. J Bone Joint Surg Am. 2006 Dec; 88(12):2726-9. PMID: 17142424.
    View in: PubMed
  97. Mesiha M, Zurakowski D, Soriano J, Nielson JH, Zarins B, Murray MM. Pathologic characteristics of the torn human meniscus. Am J Sports Med. 2007 Jan; 35(1):103-12. PMID: 17092929.
    View in: PubMed
  98. Murray MM, Spindler KP, Devin C, Snyder BS, Muller J, Takahashi M, Ballard P, Nanney LB, Zurakowski D. Use of a collagen-platelet rich plasma scaffold to stimulate healing of a central defect in the canine ACL. J Orthop Res. 2006 Apr; 24(4):820-30. PMID: 16555312.
    View in: PubMed
  99. Murray MM, Forsythe B, Chen F, Lee SJ, Yoo JJ, Atala A, Steinert A. The effect of thrombin on ACL fibroblast interactions with collagen hydrogels. J Orthop Res. 2006 Mar; 24(3):508-15. PMID: 16453341.
    View in: PubMed
  100. Spindler KP, Murray MM, Devin C, Nanney LB, Davidson JM. The central ACL defect as a model for failure of intra-articular healing. J Orthop Res. 2006 Mar; 24(3):401-6. PMID: 16479574.
    View in: PubMed
  101. Murrat, MM inventor. Methods and Procedures for Ligament Repair,. 2006.
  102. Murray, M. M., Murray, MF. Biology and Gene-Based Therapy. The Pediatric and Adolescent Knee, Micheli, LJ and Kocher, MS, eds. 2006.
  103. Steinert A., Karl N., Pilapil C., Noth U., Evans CH., Murray, M.M. Multilineage Mesenchymal Differentiation Potential of Cells Migrating out of the Anterior Cruciate Ligament. 2006.
  104. Murray, MM, Spindler, KP, Zurakowski, DA, Connolly, SA. Enhancement of suture repair of the ACL using a collagen-PRP hydrogel. 2006.
  105. Murray MM., Murray MF., Marler JM., Spindler KP., Sawyer AJ., inventors. Biologic Replacement for Fibrin Clot. 2005.
  106. Murray MM., Slocum A., Want YC., Walker D., Carvey M., Salameni A., inventors. Delivery Device for Tissue Repair. 2005.
  107. Fufa, D., Chen, F. and Murray, M.M. . The Effect of Insoluble Collagen Morphology on Fibroblast Migration, Proliferation and Collagen Production. 2005.
  108. Murray, MM., Spindler, KP. Anterior Cruciate Ligament Healing and Primary Repair. 2005; 13(3):151-156.
  109. Murray, MM, Spindler, KP. Anterior Cruciate Ligament Healing and Primary Repair. Sports Medicine and Arthroscopy Review. 2005; 13(3):151-155.
  110. Murray, M.M., Steinert, A., Evans, C., Pilapil, C., Palmer, G., Betz, O. In Situ IGF-1 Gene Transfer Enhances Healing Response in the Anterior Cruciate Ligament. 2005.
  111. Pascher A, Steinert AF, Palmer GD, Betz O, Gouze JN, Gouze E, Pilapil C, Ghivizzani SC, Evans CH, Murray MM. Enhanced repair of the anterior cruciate ligament by in situ gene transfer: evaluation in an in vitro model. Mol Ther. 2004 Aug; 10(2):327-36. PMID: 15294179.
    View in: PubMed
  112. Murray MM, Weiler A, Spindler KP. Interspecies variation in the fibroblast distribution of the anterior cruciate ligament. Am J Sports Med. 2004 Sep; 32(6):1484-91. PMID: 15310575.
    View in: PubMed
  113. Kolker D, Murray M, Wilson M. Osteochondral defects of the talus treated with autologous bone grafting. J Bone Joint Surg Br. 2004 May; 86(4):521-6. PMID: 15174546.
    View in: PubMed
  114. Murray MM, Zurakowski D, Vrahas MS. The death of articular chondrocytes after intra-articular fracture in humans. J Trauma. 2004 Jan; 56(1):128-31. PMID: 14749579.
    View in: PubMed
  115. Steinert, AF., Chen, F., Evans, CH., Murray, MM. Novel Biological Approaches to Enhance Primary Repair of the Anterior Cruciate Ligament. 2004; 81-83.
  116. Steinert, A., Palmer, G., Betz, O., Gouze, I., Gouze, JM., Pilapil, C., Ghivizzani, S., Evans, C., Murray, M.M. In Situ IGF-1 Gene Transfer for Enhancing Healing of the ACL – Evaluation in an in vitro model. Basic Science Poster Prize. 2004.
  117. Murray MM., Murray MF., Marler JM., Spindler KP., Sawyer AJ., inventors. Biologic Replacement for Fibrin Clot. 2003.
  118. Spindler KP, Murray MM, Detwiler KB, Tarter JT, Dawson JM, Nanney LB, Davidson JM. The biomechanical response to doses of TGF-beta 2 in the healing rabbit medial collateral ligament. J Orthop Res. 2003 Mar; 21(2):245-9. PMID: 12568955.
    View in: PubMed
  119. Murray, MM., Berstein, J. Meniscus. Musculoskeletal Medicine, Bernstein J, editor. 2003.
  120. Murray, M.M., section editor for Basic Science. Musculoskeletal Medicine. Bernstein, J. Senior Editor. 2003.
  121. Murray, MM, Rice, K, Wright, RJ, Spector, M. The Effect of selected growth factors on human anterior cruciate ligament cell interactions with a three dimensional collagen-GAG scaffold. J Orthop Res. 2003; 21:238-244.
  122. Murray, MM., Bernstein, J. Ligaments. Musculoskeletal Medicine, Berstein J, editor. 2003.
  123. Murray MM, Bennett R, Zhang X, Spector M. Cell outgrowth from the human ACL in vitro: regional variation and response to TGF-beta1. J Orthop Res. 2002 Jul; 20(4):875-80. PMID: 12168681.
    View in: PubMed
  124. Murray, M. M., Sawyer, A., Zurakowski, D., Gerbino, P., Micheli, L. . The effect of age on the response to injury in the human ACL. 2002.
  125. Murray, M. M., Martin, S. D., Spector, M. . Changes in cell number density and smooth muscle actin expression after rupture of the human rotator cuff tendon. 2002.
  126. Murray, MM., Mankin, HJ., Glowacki, J. The Musculoskeletal System. The Physiologic Basis of Surgery, O'Leary JP, editor. 2002.
  127. Murray, M. M., Rice, K. R., Spector, M. S.,. The effects of selected crosslinking protocols on human ACL cell interactions with 3-D collagen-GAG scaffolds. 2002.
  128. Murray MM, Spector M. The migration of cells from the ruptured human anterior cruciate ligament into collagen-glycosaminoglycan regeneration templates in vitro. Biomaterials. 2001 Sep; 22(17):2393-402. PMID: 11511036.
    View in: PubMed
  129. Murray, MM., Murray, MF., Marler JM., inventors. Biologic Replacement for Fibrin Clot. 2001.
  130. Ahluwalia S, Fehm M, Murray MM, Martin SD, Spector M. Distribution of smooth muscle actin-containing cells in the human meniscus. J Orthop Res. 2001 Jul; 19(4):659-64. PMID: 11518276.
    View in: PubMed
  131. Premdas J, Tang JB, Warner JP, Murray MM, Spector M. The presence of smooth muscle actin in fibroblasts in the torn human rotator cuff. J Orthop Res. 2001 Mar; 19(2):221-8. PMID: 11347694.
    View in: PubMed
  132. Murray, M. M., Dawson, C., Kocolas, I., Spector, M. . Gender differences in the histology of the human anterior cruciate ligament. 2001.
  133. Murray, MM., invited editorial. Effect of the intra-articular environment on healing of the ruptured anterior cruciate ligament. 2001.
  134. Murray MM, Martin SD, Martin TL, Spector M. Histological changes in the human anterior cruciate ligament after rupture. J Bone Joint Surg Am. 2000 Oct; 82-A(10):1387-97. PMID: 11057466.
    View in: PubMed
  135. Qiu W, Murray MM, Shortkroff S, Lee CR, Martin SD, Spector M. Outgrowth of chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Wound Repair Regen. 2000 Sep-Oct; 8(5):383-91. PMID: 11115150.
    View in: PubMed
  136. Murray MM, Martin SD, Spector M. Migration of cells from human anterior cruciate ligament explants into collagen-glycosaminoglycan scaffolds. J Orthop Res. 2000 Jul; 18(4):557-64. PMID: 11052491.
    View in: PubMed
  137. Murray, MM., inventor. Biologic Replacement for Fibrin Clot for Intra-articular Use. 2000.
  138. Qiu, W, Murray, MM, Shortkroff, S, Lee, CR, Martin, SD, Spector, M. Outgrowth of Chondrocytes from human articular cartilage explants and expression of alpha-smooth muscle actin. Would Repair and Regeneration. 2000; 18:383-391.
  139. Murray, MM., inventor. Biologic Replacement for Fibrin Clot for Intra-articular Use, Provisional application. 1999.
  140. Murray, M.M. E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1999.
  141. Murray, M.M. Guided Tissue Regeneration of the ACL: Preliminary Studies. 1999.
  142. Murray MM, Spector M. Fibroblast distribution in the anteromedial bundle of the human anterior cruciate ligament: the presence of alpha-smooth muscle actin-positive cells. J Orthop Res. 1999 Jan; 17(1):18-27. PMID: 10073643.
    View in: PubMed
  143. Murray, M.M. E.R. Ortho, Resident Handbook, Harvard Combined Orthopaedic Residency Program. 1998.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.