Harvard Catalyst Profiles

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Chenghua Gu, Ph.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R01HL153261 (GU, CHENGHUA) Jul 15, 2020 - Jun 30, 2024
    Neuronal and vascular interactions in the CNS
    Role: Principal Investigator
  2. R35NS116820 (GU, CHENGHUA) May 1, 2020 - Apr 30, 2028
    molecular mechanisms of the blood brain barrier function and regulation
    Role: Principal Investigator
  3. RF1DA048786 (GU, CHENGHUA) Aug 15, 2019 - Jul 31, 2022
    Validated tools for identifying, characterizing, and targeting all non-neuronal cells in the brain and determining the neuro-glio-vascular connectome
    Role: Principal Investigator
  4. DP1NS092473 (GU, CHENGHUA) Sep 30, 2014 - Jul 31, 2020
    New tools for understanding the blood brain barrier
    Role: Principal Investigator
  5. R01NS064583 (GU, CHENGHUA) Feb 1, 2010 - Jan 31, 2016
    The Role of Semaphorins in Axon and Blood Vessel Guidance
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Langen UH, Ayloo S, Gu C. Development and Cell Biology of the Blood-Brain Barrier. Annu Rev Cell Dev Biol. 2019 10 06; 35:591-613. PMID: 31299172; PMCID: PMC8934576.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  2. Kur E, Kim J, Tata A, Comin CH, Harrington KI, Costa Lda F, Bentley K, Gu C. Temporal modulation of collective cell behavior controls vascular network topology. Elife. 2016 Feb 24; 5. PMID: 26910011.
    Citations: 7     Fields:    Translation:AnimalsCells
  3. Chow BW, Gu C. The molecular constituents of the blood-brain barrier. Trends Neurosci. 2015 Oct; 38(10):598-608. PMID: 26442694; PMCID: PMC4597316.
    Citations: 118     Fields:    Translation:HumansAnimals
  4. Lacoste B, Gu C. Control of cerebrovascular patterning by neural activity during postnatal development. Mech Dev. 2015 Nov; 138 Pt 1:43-9. PMID: 26116138; PMCID: PMC4663105.
    Citations: 22     Fields:    Translation:Animals
  5. Andreone BJ, Lacoste B, Gu C. Neuronal and vascular interactions. Annu Rev Neurosci. 2015 Jul 08; 38:25-46. PMID: 25782970; PMCID: PMC5729758.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  6. Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, De Palma M, Kalluri R, LeBleu VS. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 2015 Feb 24; 10(7):1066-81. PMID: 25704811.
    Citations: 72     Fields:    Translation:AnimalsCells
  7. Almasi S, Xu X, Ben-Zvi A, Lacoste B, Gu C, Miller EL. A novel method for identifying a graph-based representation of 3-D microvascular networks from fluorescence microscopy image stacks. Med Image Anal. 2015 Feb; 20(1):208-23. PMID: 25515433.
    Citations: 3     Fields:    Translation:Animals
  8. Gelfand MV, Hagan N, Tata A, Oh WJ, Lacoste B, Kang KT, Kopycinska J, Bischoff J, Wang JH, Gu C. Neuropilin-1 functions as a VEGFR2 co-receptor to guide developmental angiogenesis independent of ligand binding. Elife. 2014 Sep 22; 3:e03720. PMID: 25244320.
    Citations: 62     Fields:    Translation:HumansAnimalsCells
  9. Lacoste B, Comin CH, Ben-Zvi A, Kaeser PS, Xu X, Costa Lda F, Gu C. Sensory-related neural activity regulates the structure of vascular networks in the cerebral cortex. Neuron. 2014 Sep 03; 83(5):1117-30. PMID: 25155955.
    Citations: 71     Fields:    Translation:AnimalsCells
  10. Straub C, Tritsch NX, Hagan NA, Gu C, Sabatini BL. Multiphasic modulation of cholinergic interneurons by nigrostriatal afferents. J Neurosci. 2014 Jun 18; 34(25):8557-69. PMID: 24948810.
    Citations: 53     Fields:    Translation:AnimalsCells
  11. Tata A, Stoppel DC, Hong S, Ben-Zvi A, Xie T, Gu C. An image-based RNAi screen identifies SH3BP1 as a key effector of Semaphorin 3E-PlexinD1 signaling. J Cell Biol. 2014 May 26; 205(4):573-90. PMID: 24841563.
    Citations: 13     Fields:    Translation:HumansCells
  12. Ben-Zvi A, Lacoste B, Kur E, Andreone BJ, Mayshar Y, Yan H, Gu C. Mfsd2a is critical for the formation and function of the blood-brain barrier. Nature. 2014 May 22; 509(7501):507-11. PMID: 24828040.
    Citations: 373     Fields:    Translation:AnimalsCells
  13. Tritsch NX, Oh WJ, Gu C, Sabatini BL. Midbrain dopamine neurons sustain inhibitory transmission using plasma membrane uptake of GABA, not synthesis. Elife. 2014 Apr 24; 3:e01936. PMID: 24843012.
    Citations: 92     Fields:    Translation:AnimalsCells
  14. Oh WJ, Gu C. Establishment of neurovascular congruency in the mouse whisker system by an independent patterning mechanism. Neuron. 2013 Oct 16; 80(2):458-69. PMID: 24139045.
    Citations: 10     Fields:    Translation:AnimalsCells
  15. Gu C, Giraudo E. The role of semaphorins and their receptors in vascular development and cancer. Exp Cell Res. 2013 May 15; 319(9):1306-16. PMID: 23422037.
    Citations: 56     Fields:    Translation:HumansAnimalsCells
  16. Oh WJ, Gu C. The role and mechanism-of-action of Sema3E and Plexin-D1 in vascular and neural development. Semin Cell Dev Biol. 2013 Mar; 24(3):156-62. PMID: 23270617.
    Citations: 39     Fields:    Translation:HumansAnimals
  17. Kwon HB, Kozorovitskiy Y, Oh WJ, Peixoto RT, Akhtar N, Saulnier JL, Gu C, Sabatini BL. Neuroligin-1-dependent competition regulates cortical synaptogenesis and synapse number. Nat Neurosci. 2012 Dec; 15(12):1667-74. PMID: 23143522.
    Citations: 93     Fields:    Translation:HumansAnimalsCells
  18. Ding JB, Oh WJ, Sabatini BL, Gu C. Semaphorin 3E-Plexin-D1 signaling controls pathway-specific synapse formation in the striatum. Nat Neurosci. 2011 Dec 18; 15(2):215-23. PMID: 22179111; PMCID: PMC3267860.
    Citations: 54     Fields:    Translation:AnimalsCells
  19. Kim J, Oh WJ, Gaiano N, Yoshida Y, Gu C. Semaphorin 3E-Plexin-D1 signaling regulates VEGF function in developmental angiogenesis via a feedback mechanism. Genes Dev. 2011 Jul 01; 25(13):1399-411. PMID: 21724832.
    Citations: 92     Fields:    Translation:HumansAnimalsCells
  20. Ruiz de Almodovar C, Fabre PJ, Knevels E, Coulon C, Segura I, Haddick PC, Aerts L, Delattin N, Strasser G, Oh WJ, Lange C, Vinckier S, Haigh J, Fouquet C, Gu C, Alitalo K, Castellani V, Tessier-Lavigne M, Chedotal A, Charron F, Carmeliet P. VEGF mediates commissural axon chemoattraction through its receptor Flk1. Neuron. 2011 Jun 09; 70(5):966-78. PMID: 21658588.
    Citations: 57     Fields:    Translation:AnimalsCells
  21. Piper M, Plachez C, Zalucki O, Fothergill T, Goudreau G, Erzurumlu R, Gu C, Richards LJ. Neuropilin 1-Sema signaling regulates crossing of cingulate pioneering axons during development of the corpus callosum. Cereb Cortex. 2009 Jul; 19 Suppl 1:i11-21. PMID: 19357391.
    Citations: 44     Fields:    Translation:AnimalsCells
  22. Gelfand MV, Hong S, Gu C. Guidance from above: common cues direct distinct signaling outcomes in vascular and neural patterning. Trends Cell Biol. 2009 Mar; 19(3):99-110. PMID: 19200729.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  23. Huber AB, Kania A, Tran TS, Gu C, De Marco Garcia N, Lieberam I, Johnson D, Jessell TM, Ginty DD, Kolodkin AL. Distinct roles for secreted semaphorin signaling in spinal motor axon guidance. Neuron. 2005 Dec 22; 48(6):949-64. PMID: 16364899.
    Citations: 98     Fields:    Translation:AnimalsCells
  24. Gammill LS, Gonzalez C, Gu C, Bronner-Fraser M. Guidance of trunk neural crest migration requires neuropilin 2/semaphorin 3F signaling. Development. 2006 Jan; 133(1):99-106. PMID: 16319111.
    Citations: 75     Fields:    Translation:AnimalsCells
  25. Mukouyama YS, Gerber HP, Ferrara N, Gu C, Anderson DJ. Peripheral nerve-derived VEGF promotes arterial differentiation via neuropilin 1-mediated positive feedback. Development. 2005 Mar; 132(5):941-52. PMID: 15673567.
    Citations: 91     Fields:    Translation:AnimalsCells
  26. Gu C, Yoshida Y, Livet J, Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 2005 Jan 14; 307(5707):265-8. PMID: 15550623.
    Citations: 205     Fields:    Translation:AnimalsCells
  27. Schwarz Q, Gu C, Fujisawa H, Sabelko K, Gertsenstein M, Nagy A, Taniguchi M, Kolodkin AL, Ginty DD, Shima DT, Ruhrberg C. Vascular endothelial growth factor controls neuronal migration and cooperates with Sema3A to pattern distinct compartments of the facial nerve. Genes Dev. 2004 Nov 15; 18(22):2822-34. PMID: 15545635; PMCID: PMC528901.
    Citations: 85     Fields:    Translation:AnimalsCells
  28. Gu C, Rodriguez ER, Reimert DV, Shu T, Fritzsch B, Richards LJ, Kolodkin AL, Ginty DD. Neuropilin-1 conveys semaphorin and VEGF signaling during neural and cardiovascular development. Dev Cell. 2003 Jul; 5(1):45-57. PMID: 12852851; PMCID: PMC3918747.
    Citations: 306     Fields:    Translation:AnimalsCells
  29. Gu C, Limberg BJ, Whitaker GB, Perman B, Leahy DJ, Rosenbaum JS, Ginty DD, Kolodkin AL. Characterization of neuropilin-1 structural features that confer binding to semaphorin 3A and vascular endothelial growth factor 165. J Biol Chem. 2002 May 17; 277(20):18069-76. PMID: 11886873.
    Citations: 99     Fields:    Translation:HumansAnimalsCells
  30. Gu C, Ma YC, Benjamin J, Littman D, Chao MV, Huang XY. Apoptotic signaling through the beta -adrenergic receptor. A new Gs effector pathway. J Biol Chem. 2000 Jul 07; 275(27):20726-33. PMID: 10767282.
    Citations: 22     Fields:    Translation:AnimalsCells
  31. Casaccia-Bonnefil P, Gu C, Khursigara G, Chao MV. p75 neurotrophin receptor as a modulator of survival and death decisions. Microsc Res Tech. 1999 May 15-Jun 1; 45(4-5):217-24. PMID: 10383114.
    Citations: 22     Fields:    Translation:HumansAnimalsCells
  32. Gu C, Casaccia-Bonnefil P, Srinivasan A, Chao MV. Oligodendrocyte apoptosis mediated by caspase activation. J Neurosci. 1999 Apr 15; 19(8):3043-9. PMID: 10191321; PMCID: PMC6782261.
    Citations: 34     Fields:    Translation:AnimalsCells
  33. Casaccia-Bonnefil P, Gu C, Chao MV. Neurotrophins in cell survival/death decisions. Adv Exp Med Biol. 1999; 468:275-82. PMID: 10635036.
    Citations: 36     Fields:    Translation:AnimalsCells
  34. Gu C, Castellino A, Chan JY, Chao MV. BRE: a modulator of TNF-alpha action. FASEB J. 1998 Sep; 12(12):1101-8. PMID: 9737713.
    Citations: 20     Fields:    Translation:HumansAnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.