Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Teresa Gomez-Isla, M.D.


The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. RF1AG061206 (GOMEZ-ISLA, TERESA) Feb 15, 2019 - Jan 31, 2024
    Postmortem validation of novel tau PET tracers
    Role: Principal Investigator
  2. R01AG061206 (GOMEZ-ISLA, TERESA) Feb 15, 2019 - Nov 30, 2023
    Postmortem validation of novel tau PET tracers
    Role: Principal Investigator
  3. P01AG036694 (SPERLING, REISA A.) Jul 1, 2018 - Jun 30, 2015
    Impact of Amyloid and Tau on the Aging Brain: The Harvard Aging Brain Study
    Role: Co-Principal Investigator
  4. R01AG043511 (GOMEZ-ISLA, TERESA) Sep 1, 2013 - Jun 30, 2018
    Dissecting molecular mechanisms involved in resilience of Alzheimer's pathology
    Role: Principal Investigator
  5. P50AG005134 (HYMAN, BRADLEY T.) Mar 1, 1985 - Aug 31, 1989
    Massachusetts Alzheimer's Disease Research Center
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Gomez-Isla T. Editorial: Understanding factors that, beyond plaques and tangles, contribute to the heterogeneity of Alzheimer disease and implications for the development of biomarkers and design of interventions. Curr Opin Neurol. 2021 Apr 01; 34(2):226-227. PMID: 33664207.
    Citations:    Fields:    
  2. Wilkins JM, Locascio JJ, Gunther JM, Yap L, Gomez-Isla T, Hyman BT, Blacker D, Forester BP, Okereke OI. Predictors of the importance of everyday preferences for older adults with cognitive impairment. Int Psychogeriatr. 2021 Jan 18; 1-8. PMID: 33455605.
    Citations:    Fields:    
  3. Amaral AC, Perez-Nievas BG, Siao Tick Chong M, Gonzalez-Martinez A, Argente-Escrig H, Rubio-Guerra S, Commins C, Muftu S, Eftekharzadeh B, Hudry E, Fan Z, Ramanan P, Takeda S, Frosch MP, Wegmann S, Gomez-Isla T. Isoform-selective decrease of glycogen synthase kinase-3-beta (GSK-3ß) reduces synaptic tau phosphorylation, transcellular spreading, and aggregation. iScience. 2021 Feb 19; 24(2):102058. PMID: 33554064.
  4. Gomez-Isla T, Frosch MP. The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms. JAMA Neurol. 2019 Jul 15. PMID: 31305888.
    Citations: 2     Fields:    
  5. Shirvan J, Clement N, Ye R, Katz S, Schultz A, Johnson KA, Gomez-Isla T, Frosch M, Growdon JH, Gomperts SN. Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease. Neurology. 2019 07 30; 93(5):e476-e484. PMID: 31243072.
    Citations: 3     Fields:    Translation:Humans
  6. Aguero C, Dhaynaut M, Normandin MD, Amaral AC, Guehl NJ, Neelamegam R, Marquie M, Johnson KA, El Fakhri G, Frosch MP, Gomez-Isla T. Autoradiography validation of novel tau PET tracer [F-18]-MK-6240 on human postmortem brain tissue. Acta Neuropathol Commun. 2019 03 11; 7(1):37. PMID: 30857558.
    Citations: 9     Fields:    Translation:Humans
  7. Buckley RF, Mormino EC, Chhatwal J, Schultz AP, Rabin JS, Rentz DM, Acar D, Properzi MJ, Dumurgier J, Jacobs H, Gomez-Isla T, Johnson KA, Sperling RA, Hanseeuw BJ. Associations between baseline amyloid, sex, and APOE on subsequent tau accumulation in cerebrospinal fluid. Neurobiol Aging. 2019 06; 78:178-185. PMID: 30947113.
    Citations: 9     Fields:    Translation:Humans
  8. Barroeta-Espar I, Weinstock LD, Perez-Nievas BG, Meltzer AC, Siao Tick Chong M, Amaral AC, Murray ME, Moulder KL, Morris JC, Cairns NJ, Parisi JE, Lowe VJ, Petersen RC, Kofler J, Ikonomovic MD, López O, Klunk WE, Mayeux RP, Frosch MP, Wood LB, Gomez-Isla T. Distinct cytokine profiles in human brains resilient to Alzheimer's pathology. Neurobiol Dis. 2019 01; 121:327-337. PMID: 30336198.
    Citations: 16     Fields:    Translation:HumansCells
  9. Lindemer ER, Greve DN, Fischl B, Salat DH, Gomez-Isla T. White matter abnormalities and cognition in patients with conflicting diagnoses and CSF profiles. Neurology. 2018 04 24; 90(17):e1461-e1469. PMID: 29572277.
    Citations: 2     Fields:    Translation:Humans
  10. Xia C, Makaretz SJ, Caso C, McGinnis S, Gomperts SN, Sepulcre J, Gomez-Isla T, Hyman BT, Schultz A, Vasdev N, Johnson KA, Dickerson BC. Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease. JAMA Neurol. 2017 04 01; 74(4):427-436. PMID: 28241163.
    Citations: 82     Fields:    Translation:Humans
  11. Dhilla Albers A, Asafu-Adjei J, Delaney MK, Kelly KE, Gomez-Isla T, Blacker D, Johnson KA, Sperling RA, Hyman BT, Betensky RA, Hastings L, Albers MW. Episodic memory of odors stratifies Alzheimer biomarkers in normal elderly. Ann Neurol. 2016 12; 80(6):846-857. PMID: 27696605.
    Citations: 11     Fields:    Translation:Humans
  12. Liu J, Costantino I, Venugopalan N, Fischetti RF, Hyman BT, Frosch MP, Gomez-Isla T, Makowski L. Amyloid structure exhibits polymorphism on multiple length scales in human brain tissue. Sci Rep. 2016 09 15; 6:33079. PMID: 27629394.
    Citations: 16     Fields:    Translation:Humans
  13. Chhatwal JP, Schultz AP, Marshall GA, Boot B, Gomez-Isla T, Dumurgier J, LaPoint M, Scherzer C, Roe AD, Hyman BT, Sperling RA, Johnson KA. Temporal T807 binding correlates with CSF tau and phospho-tau in normal elderly. Neurology. 2016 Aug 30; 87(9):920-6. PMID: 27473132.
    Citations: 49     Fields:    Translation:HumansCells
  14. Sepulcre J, Schultz AP, Sabuncu M, Gomez-Isla T, Chhatwal J, Becker A, Sperling R, Johnson KA. In Vivo Tau, Amyloid, and Gray Matter Profiles in the Aging Brain. J Neurosci. 2016 07 13; 36(28):7364-74. PMID: 27413148.
    Citations: 58     Fields:    Translation:Humans
  15. Johnson KA, Schultz A, Betensky RA, Becker JA, Sepulcre J, Rentz D, Mormino E, Chhatwal J, Amariglio R, Papp K, Marshall G, Albers M, Mauro S, Pepin L, Alverio J, Judge K, Philiossaint M, Shoup T, Yokell D, Dickerson B, Gomez-Isla T, Hyman B, Vasdev N, Sperling R. Tau positron emission tomographic imaging in aging and early Alzheimer disease. Ann Neurol. 2016 Jan; 79(1):110-9. PMID: 26505746.
    Citations: 289     Fields:    Translation:Humans
  16. Donovan NJ, Amariglio RE, Zoller AS, Rudel RK, Gomez-Isla T, Blacker D, Hyman BT, Locascio JJ, Johnson KA, Sperling RA, Marshall GA, Rentz DM. Subjective cognitive concerns and neuropsychiatric predictors of progression to the early clinical stages of Alzheimer disease. Am J Geriatr Psychiatry. 2014 Dec; 22(12):1642-51. PMID: 24698445.
    Citations: 61     Fields:    Translation:Humans
  17. Pooler AM, Polydoro M, Wegmann SK, Pitstick R, Kay KR, Sanchez L, Carlson GA, Gomez-Isla T, Albers MW, Spires-Jones TL, Hyman BT. Tau-amyloid interactions in the rTgTauEC model of early Alzheimer's disease suggest amyloid-induced disruption of axonal projections and exacerbated axonal pathology. J Comp Neurol. 2013 Dec 15; 521(18):4236-48. PMID: 23839581.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  18. Vargas T, Martinez-Garcia A, Antequera D, Vilella E, Clarimon J, Mateo I, Sanchez-Juan P, Rodriguez-Rodriguez E, Frank A, Rosich-Estrago M, Lleo A, Molina-Porcel L, Blesa R, Gomez-Isla T, Combarros O, Bermejo-Pareja F, Valdivieso F, Bullido MJ, Carro E. IGF-I gene variability is associated with an increased risk for AD. Neurobiol Aging. 2011 Mar; 32(3):556.e3-11. PMID: 21176999.
    Citations: 14     Fields:    Translation:Humans
  19. Vargas T, Bullido MJ, Martinez-Garcia A, Antequera D, Clarimon J, Rosich-Estrago M, Martin-Requero A, Mateo I, Rodriguez-Rodriguez E, Vilella-Cuadrada E, Frank A, Lleo A, Molina-Porcel L, Blesa R, Combarros O, Gomez-Isla T, Bermejo-Pareja F, Valdivieso F, Carro E. A megalin polymorphism associated with promoter activity and Alzheimer's disease risk. . 2010 Jun 05; 153B(4):895-902. PMID: 20052685.
    Citations: 10     Translation:HumansCells
  20. Galluzzi S, Talassi E, Belussi M, Scheltens P, van de Pol L, Nobili F, Rodriguez G, Froelich L, Damian M, Martinez-Lage P, Gomez-Isla T, Reynish E, Ousset PJ, Vellas B, Frisoni GB. Multi-center comparison of medial temporal atrophy in patients with Alzheimer's disease--data from the ICTUS study. Dement Geriatr Cogn Disord. 2008; 26(4):314-22. PMID: 18841016.
    Citations: 1     Fields:    Translation:Humans
  21. Gomez-Isla T, Spires T, De Calignon A, Hyman BT. Neuropathology of Alzheimer's disease. Handb Clin Neurol. 2008; 89:233-43. PMID: 18631748.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  22. Dufty BM, Warner LR, Hou ST, Jiang SX, Gomez-Isla T, Leenhouts KM, Oxford JT, Feany MB, Masliah E, Rohn TT. Calpain-cleavage of alpha-synuclein: connecting proteolytic processing to disease-linked aggregation. Am J Pathol. 2007 May; 170(5):1725-38. PMID: 17456777.
    Citations: 95     Fields:    Translation:HumansAnimalsCells
  23. Ferrer I, Gomez-Isla T, Puig B, Freixes M, Ribé E, Dalfó E, Avila J. Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies. Curr Alzheimer Res. 2005 Jan; 2(1):3-18. PMID: 15977985.
    Citations: 83     Fields:    Translation:HumansAnimalsCells
  24. Angulo E, Noé V, Casadó V, Mallol J, Gomez-Isla T, Lluis C, Ferrer I, Ciudad CJ, Franco R. Up-regulation of the Kv3.4 potassium channel subunit in early stages of Alzheimer's disease. J Neurochem. 2004 Nov; 91(3):547-57. PMID: 15485486.
    Citations: 32     Fields:    Translation:HumansAnimalsCells
  25. Gomez-Isla T, Irizarry MC, Mariash A, Cheung B, Soto O, Schrump S, Sondel J, Kotilinek L, Day J, Schwarzschild MA, Cha JH, Newell K, Miller DW, Uéda K, Young AB, Hyman BT, Ashe KH. Motor dysfunction and gliosis with preserved dopaminergic markers in human alpha-synuclein A30P transgenic mice. Neurobiol Aging. 2003 Mar-Apr; 24(2):245-58. PMID: 12498958.
    Citations: 53     Fields:    Translation:HumansAnimals
  26. Steidl JV, Gomez-Isla T, Mariash A, Ashe KH, Boland LM. Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice. Neuroreport. 2003 Feb 10; 14(2):219-23. PMID: 12598733.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  27. Carro E, Trejo JL, Gomez-Isla T, LeRoith D, Torres-Aleman I. Serum insulin-like growth factor I regulates brain amyloid-beta levels. Nat Med. 2002 Dec; 8(12):1390-7. PMID: 12415260.
    Citations: 163     Fields:    Translation:Animals
  28. Killiany RJ, Hyman BT, Gomez-Isla T, Moss MB, Kikinis R, Jolesz F, Tanzi R, Jones K, Albert MS. MRI measures of entorhinal cortex vs hippocampus in preclinical AD. Neurology. 2002 Apr 23; 58(8):1188-96. PMID: 11971085.
    Citations: 153     Fields:    Translation:Humans
  29. Greeve I, Hermans-Borgmeyer I, Brellinger C, Kasper D, Gomez-Isla T, Behl C, Levkau B, Nitsch RM. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci. 2000 Oct 01; 20(19):7345-52. PMID: 11007892.
    Citations: 78     Fields:    Translation:HumansAnimalsCells
  30. Cataldo AM, Peterhoff CM, Troncoso JC, Gomez-Isla T, Hyman BT, Nixon RA. Endocytic pathway abnormalities precede amyloid beta deposition in sporadic Alzheimer's disease and Down syndrome: differential effects of APOE genotype and presenilin mutations. Am J Pathol. 2000 Jul; 157(1):277-86. PMID: 10880397.
    Citations: 285     Fields:    Translation:HumansCells
  31. Buldyrev SV, Cruz L, Gomez-Isla T, Gomez-Tortosa E, Havlin S, Le R, Stanley HE, Urbanc B, Hyman BT. Description of microcolumnar ensembles in association cortex and their disruption in Alzheimer and Lewy body dementias. Proc Natl Acad Sci U S A. 2000 May 09; 97(10):5039-43. PMID: 10805766.
    Citations: 28     Fields:    Translation:HumansCells
  32. Killiany RJ, Gomez-Isla T, Moss M, Kikinis R, Sandor T, Jolesz F, Tanzi R, Jones K, Hyman BT, Albert MS. Use of structural magnetic resonance imaging to predict who will get Alzheimer's disease. Ann Neurol. 2000 Apr; 47(4):430-9. PMID: 10762153.
    Citations: 187     Fields:    Translation:Humans
  33. Greenberg SM, Tennis MK, Brown LB, Gomez-Isla T, Hayden DL, Schoenfeld DA, Walsh KL, Corwin C, Daffner KR, Friedman P, Meadows ME, Sperling RA, Growdon JH. Donepezil therapy in clinical practice: a randomized crossover study. Arch Neurol. 2000 Jan; 57(1):94-9. PMID: 10634454.
    Citations: 38     Fields:    Translation:HumansCTClinical Trials
  34. Irizarry MC, Ghaemi SN, Lee-Cherry ER, Gomez-Isla T, Binetti G, Hyman BT, Growdon JH. Risperidone treatment of behavioral disturbances in outpatients with dementia. J Neuropsychiatry Clin Neurosci. 1999; 11(3):336-42. PMID: 10440009.
    Citations: 5     Fields:    Translation:Humans
  35. Knowles RB, Gomez-Isla T, Hyman BT. Abeta associated neuropil changes: correlation with neuronal loss and dementia. J Neuropathol Exp Neurol. 1998 Dec; 57(12):1122-30. PMID: 9862634.
    Citations: 23     Fields:    Translation:HumansCells
  36. Etiene D, Kraft J, Ganju N, Gomez-Isla T, Gemelli B, Hyman BT, Hedley-Whyte ET, Wands JR, De La Monte SM. Cerebrovascular Pathology Contributes to the Heterogeneity of Alzheimer's Disease. J Alzheimers Dis. 1998 Dec; 1(2):119-134. PMID: 12214008.
    Citations: 16     Fields:    
  37. Liao A, Nitsch RM, Greenberg SM, Finckh U, Blacker D, Albert M, Rebeck GW, Gomez-Isla T, Clatworthy A, Binetti G, Hock C, Mueller-Thomsen T, Mann U, Zuchowski K, Beisiegel U, Staehelin H, Growdon JH, Tanzi RE, Hyman BT. Genetic association of an alpha2-macroglobulin (Val1000lle) polymorphism and Alzheimer's disease. Hum Mol Genet. 1998 Nov; 7(12):1953-6. PMID: 9811940.
    Citations: 17     Fields:    Translation:HumansCells
  38. McNamara MJ, Gomez-Isla T, Hyman BT. Apolipoprotein E genotype and deposits of Abeta40 and Abeta42 in Alzheimer disease. Arch Neurol. 1998 Jul; 55(7):1001-4. PMID: 9678319.
    Citations: 10     Fields:    Translation:HumansCTClinical Trials
  39. Irizarry MC, Growdon W, Gomez-Isla T, Newell K, George JM, Clayton DF, Hyman BT. Nigral and cortical Lewy bodies and dystrophic nigral neurites in Parkinson's disease and cortical Lewy body disease contain alpha-synuclein immunoreactivity. J Neuropathol Exp Neurol. 1998 Apr; 57(4):334-7. PMID: 9600226.
    Citations: 95     Fields:    Translation:HumansCells
  40. Hyman BT, Gomez-Isla T, Irizarry MC. Stereology: a practical primer for neuropathology. J Neuropathol Exp Neurol. 1998 Apr; 57(4):305-10. PMID: 9600222.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  41. Clatworthy AE, Gomez-Isla T, Rebeck GW, Wallace RB, Hyman BT. Lack of association of a polymorphism in the low-density lipoprotein receptor-related protein gene with Alzheimer disease. Arch Neurol. 1997 Oct; 54(10):1289-92. PMID: 9341576.
    Citations: 5     Fields:    Translation:HumansCells
  42. Hyman BT, Gomez-Isla T. The natural history of Alzheimer neurofibrillary tangles and amyloid deposits. Neurobiol Aging. 1997 Jul-Aug; 18(4):386-7; discussion 389-92. PMID: 9330968.
    Citations: 7     Fields:    Translation:HumansCells
  43. Hyman BT, Gomez-Isla T, Rebeck GW, Briggs M, Chung H, West HL, Greenberg S, Mui S, Nichols S, Wallace R, Growdon JH. Epidemiological, clinical, and neuropathological study of apolipoprotein E genotype in Alzheimer's disease. Ann N Y Acad Sci. 1996 Dec 16; 802:1-5. PMID: 8993478.
    Citations: 21     Fields:    Translation:Humans
  44. Hyman BT, Gomez-Isla T. Neuropathological markers of impaired cognition in the entorhinal cortex. Neurobiol Aging. 1996 Nov-Dec; 17(6):940-1; discussion 945-7. PMID: 9363808.
    Citations: 1     Fields:    Translation:Humans
  45. Growdon JH, Locascio JJ, Corkin S, Gomez-Isla T, Hyman BT. Apolipoprotein E genotype does not influence rates of cognitive decline in Alzheimer's disease. Neurology. 1996 Aug; 47(2):444-8. PMID: 8757018.
    Citations: 32     Fields:    Translation:Humans
  46. Mui S, Briggs M, Chung H, Wallace RB, Gomez-Isla T, Rebeck GW, Hyman BT. A newly identified polymorphism in the apolipoprotein E enhancer gene region is associated with Alzheimer's disease and strongly with the epsilon 4 allele. Neurology. 1996 Jul; 47(1):196-201. PMID: 8710077.
    Citations: 10     Fields:    Translation:HumansCells
  47. Hyman BT, Gomez-Isla T, Briggs M, Chung H, Nichols S, Kohout F, Wallace R. Apolipoprotein E and cognitive change in an elderly population. Ann Neurol. 1996 Jul; 40(1):55-66. PMID: 8687193.
    Citations: 41     Fields:    Translation:Humans
  48. Hyman BT, Gomez-Isla T, West H, Briggs M, Chung H, Growdon JH, Rebeck GW. Clinical and neuropathological correlates of apolipoprotein E genotype in Alzheimer's disease. Window on molecular epidemiology. Ann N Y Acad Sci. 1996 Jan 17; 777:158-65. PMID: 8624079.
    Citations: 9     Fields:    Translation:Humans
  49. Gomez-Isla T, West HL, Rebeck GW, Harr SD, Growdon JH, Locascio JJ, Perls TT, Lipsitz LA, Hyman BT. Clinical and pathological correlates of apolipoprotein E epsilon 4 in Alzheimer's disease. Ann Neurol. 1996 Jan; 39(1):62-70. PMID: 8572669.
    Citations: 80     Fields:    Translation:HumansCells
  50. Greenberg SM, Rebeck GW, Vonsattel JP, Gomez-Isla T, Hyman BT. Apolipoprotein E epsilon 4 and cerebral hemorrhage associated with amyloid angiopathy. Ann Neurol. 1995 Aug; 38(2):254-9. PMID: 7654074.
    Citations: 117     Fields:    Translation:HumansCells
  51. Hyman BT, Gomez-Isla T. Alzheimer's disease is a laminar, regional, and neural system specific disease, not a global brain disease. Neurobiol Aging. 1994 May-Jun; 15(3):353-4; discussion 379-80. PMID: 7936060.
    Citations: 16     Fields:    Translation:HumansCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.