Harvard Catalyst Profiles

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Alejandro Benjamin Balazs, Ph.D.

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Research
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  1. DP2DA040254 (BALAZS, ALEJANDRO BENJAMIN) Jul 1, 2015 - Jun 30, 2020
    NIH/NIDA
    Engineering Humoral Immunity to Functionally Cure HIV Infection
    Role: Principal Investigator
  2. K22AI102769 (BALAZS, ALEJANDRO BENJAMIN) Feb 1, 2014 - Jan 31, 2016
    NIH/NIAID
    Development of Vectored ImmunoProphylaxis as a strategy against HIV
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Crawford KHD, Eguia R, Dingens AS, Loes AN, Malone KD, Wolf CR, Chu HY, Tortorici MA, Veesler D, Murphy M, Pettie D, King NP, Balazs AB, Bloom JD. Protocol and Reagents for Pseudotyping Lentiviral Particles with SARS-CoV-2 Spike Protein for Neutralization Assays. Viruses. 2020 05 06; 12(5). PMID: 32384820.
    Citations:    
  2. Keating CL, Kuhn E, Bals J, Cocco AR, Yousif AS, Matysiak C, Sangesland M, Ronsard L, Smoot M, Moreno TB, Okonkwo V, Setliff I, Georgiev I, Balazs AB, Carr SA, Lingwood D. Spontaneous Glycan Reattachment Following N-Glycanase Treatment of Influenza and HIV Vaccine Antigens. J Proteome Res. 2020 Feb 07; 19(2):733-743. PMID: 31913636.
    Citations:    
  3. Huang Q, Chan KY, Tobey IG, Chan YA, Poterba T, Boutros CL, Balazs AB, Daneman R, Bloom JM, Seed C, Deverman BE. Delivering genes across the blood-brain barrier: LY6A, a novel cellular receptor for AAV-PHP.B capsids. PLoS One. 2019; 14(11):e0225206. PMID: 31725765.
    Citations:    
  4. van den Berg FT, Makoah NA, Ali SA, Scott TA, Mapengo RE, Mutsvunguma LZ, Mkhize NN, Lambson BE, Kgagudi PD, Crowther C, Abdool Karim SS, Balazs AB, Weinberg MS, Ely A, Arbuthnot PB, Morris L. AAV-Mediated Expression of Broadly Neutralizing and Vaccine-like Antibodies Targeting the HIV-1 Envelope V2 Region. Mol Ther Methods Clin Dev. 2019 Sep 13; 14:100-112. PMID: 31334303.
    Citations:    
  5. Welles HC, Jennewein MF, Mason RD, Narpala S, Wang L, Cheng C, Zhang Y, Todd JP, Lifson JD, Balazs AB, Alter G, McDermott AB, Mascola JR, Roederer M. Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge. PLoS Pathog. 2018 12; 14(12):e1007395. PMID: 30517201.
    Citations:    Fields:    
  6. Lin A, Balazs AB. Adeno-associated virus gene delivery of broadly neutralizing antibodies as prevention and therapy against HIV-1. Retrovirology. 2018 10 01; 15(1):66. PMID: 30285769.
    Citations:    Fields:    
  7. Brady JM, Baltimore D, Balazs AB. Antibody gene transfer with adeno-associated viral vectors as a method for HIV prevention. Immunol Rev. 2017 01; 275(1):324-333. PMID: 28133808.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  8. Payne JG, Takahashi A, Higgins MI, Porter EL, Suki B, Balazs A, Wilson AA. Multilineage transduction of resident lung cells in vivo by AAV2/8 for a1-antitrypsin gene therapy. Mol Ther Methods Clin Dev. 2016; 3:16042. PMID: 27408904.
    Citations: 1     
  9. Thomas DD, Sommer AG, Balazs AB, Beerman I, Murphy GJ, Rossi D, Mostoslavsky G. Insulin-like growth factor 2 modulates murine hematopoietic stem cell maintenance through upregulation of p57. Exp Hematol. 2016 May; 44(5):422-433.e1. PMID: 26872540.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Akkina R, Allam A, Balazs AB, Blankson JN, Burnett JC, Casares S, Garcia JV, Hasenkrug KJ, Kashanchi F, Kitchen SG, Klein F, Kumar P, Luster AD, Poluektova LY, Rao M, Sanders-Beer BE, Shultz LD, Zack JA. Improvements and Limitations of Humanized Mouse Models for HIV Research: NIH/NIAID "Meet the Experts" 2015 Workshop Summary. AIDS Res Hum Retroviruses. 2016 Feb; 32(2):109-19. PMID: 26670361.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  11. Saunders KO, Wang L, Joyce MG, Yang ZY, Balazs AB, Cheng C, Ko SY, Kong WP, Rudicell RS, Georgiev IS, Duan L, Foulds KE, Donaldson M, Xu L, Schmidt SD, Todd JP, Baltimore D, Roederer M, Haase AT, Kwong PD, Rao SS, Mascola JR, Nabel GJ. Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection. J Virol. 2015 Aug; 89(16):8334-45. PMID: 26041300.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  12. Deal CE, Balazs AB. Engineering humoral immunity as prophylaxis or therapy. Curr Opin Immunol. 2015 Aug; 35:113-22. PMID: 26183209.
    Citations: 6     Fields:    Translation:HumansAnimals
  13. Deal CE, Balazs AB. Vectored antibody gene delivery for the prevention or treatment of HIV infection. Curr Opin HIV AIDS. 2015 May; 10(3):190-7. PMID: 25700206.
    Citations: 10     Fields:    Translation:HumansCells
  14. Deal C, Ouyang Y, Hong CM, An DS, Baltimore D, Balazs AB. Durable Suppression of Established Transmitted Founder Replication in Infected BLT Humanized Mice by Vectored ImmunoTherapy. AIDS Res Hum Retroviruses. 2014 Oct; 30 Suppl 1:A16-7. PMID: 25357447.
    Citations:    
  15. de Jong YP, Dorner M, Mommersteeg MC, Xiao JW, Balazs AB, Robbins JB, Winer BY, Gerges S, Vega K, Labitt RN, Donovan BM, Giang E, Krishnan A, Chiriboga L, Charlton MR, Burton DR, Baltimore D, Law M, Rice CM, Ploss A. Broadly neutralizing antibodies abrogate established hepatitis C virus infection. Sci Transl Med. 2014 Sep 17; 6(254):254ra129. PMID: 25232181.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  16. Deal C, Balazs AB, Espinosa DA, Zavala F, Baltimore D, Ketner G. Vectored antibody gene delivery protects against Plasmodium falciparum sporozoite challenge in mice. Proc Natl Acad Sci U S A. 2014 Aug 26; 111(34):12528-32. PMID: 25114213.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  17. Balazs AB, Ouyang Y, Hong CM, Chen J, Nguyen SM, Rao DS, An DS, Baltimore D. Vectored immunoprophylaxis protects humanized mice from mucosal HIV transmission. Nat Med. 2014 Mar; 20(3):296-300. PMID: 24509526.
    Citations: 72     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  18. Balazs AB, Bloom JD, Hong CM, Rao DS, Baltimore D. Broad protection against influenza infection by vectored immunoprophylaxis in mice. Nat Biotechnol. 2013 Jul; 31(7):647-52. PMID: 23728362.
    Citations: 39     Fields:    Translation:HumansAnimalsCellsPHPublic Health
  19. Balazs AB, West AP. Antibody gene transfer for HIV immunoprophylaxis. Nat Immunol. 2013 Jan; 14(1):1-5. PMID: 23238748.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  20. Balazs AB, Chen J, Hong CM, Rao DS, Yang L, Baltimore D. Antibody-based protection against HIV infection by vectored immunoprophylaxis. Nature. 2011 Nov 30; 481(7379):81-4. PMID: 22139420.
    Citations: 202     Fields:    Translation:HumansAnimalsCells
  21. Sigal A, Kim JT, Balazs AB, Dekel E, Mayo A, Milo R, Baltimore D. Cell-to-cell spread of HIV permits ongoing replication despite antiretroviral therapy. Nature. 2011 Aug 17; 477(7362):95-8. PMID: 21849975.
    Citations: 157     Fields:    Translation:HumansCells
  22. Luo XM, Lei MY, Feidi RA, West AP, Balazs AB, Bjorkman PJ, Yang L, Baltimore D. Dimeric 2G12 as a potent protection against HIV-1. PLoS Pathog. 2010 Dec 16; 6(12):e1001225. PMID: 21187894.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  23. O'Connell RM, Balazs AB, Rao DS, Kivork C, Yang L, Baltimore D. Lentiviral vector delivery of human interleukin-7 (hIL-7) to human immune system (HIS) mice expands T lymphocyte populations. PLoS One. 2010 Aug 06; 5(8):e12009. PMID: 20700454.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  24. O'Connell RM, Chaudhuri AA, Rao DS, Gibson WS, Balazs AB, Baltimore D. MicroRNAs enriched in hematopoietic stem cells differentially regulate long-term hematopoietic output. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14235-40. PMID: 20660734.
    Citations: 114     Fields:    Translation:HumansAnimalsCells
  25. Austin KM, Gupta ML, Coats SA, Tulpule A, Mostoslavsky G, Balazs AB, Mulligan RC, Daley G, Pellman D, Shimamura A. Mitotic spindle destabilization and genomic instability in Shwachman-Diamond syndrome. J Clin Invest. 2008 Apr; 118(4):1511-8. PMID: 18324336.
    Citations: 30     Fields:    Translation:HumansCells
  26. Balazs AB, Fabian AJ, Esmon CT, Mulligan RC. Endothelial protein C receptor (CD201) explicitly identifies hematopoietic stem cells in murine bone marrow. Blood. 2006 Mar 15; 107(6):2317-21. PMID: 16304059.
    Citations: 66     Fields:    Translation:AnimalsCells
  27. Michurina T, Krasnov P, Balazs A, Nakaya N, Vasilieva T, Kuzin B, Khrushchov N, Mulligan RC, Enikolopov G. Nitric oxide is a regulator of hematopoietic stem cell activity. Mol Ther. 2004 Aug; 10(2):241-8. PMID: 15294171.
    Citations: 12     Fields:    Translation:AnimalsCells
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.