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Thomas Michel, M.D., Ph.D.

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Mentoring
Available: 06/29/11, Expires: 01/15/21

My lab uses biochemical and cell biological approaches to explore signal transduction pathways in the cells and tissues of the cardiovascular system, with a particular focus on the study of nitric oxide synthase pathways in endothelial cells and cardiac myocytes– and their alterations in disease states. Nitric oxide (NO) is the active compound formed from important cardiovascular drugs such as nitroglycerin, and is synthesized in the body by a family of nitric oxide synthases. The endothelial isoform of nitric oxide synthase (eNOS) is a key signaling enzyme that is activated by cell surface receptors and modulates vascular smooth muscle relaxation, cardiac myocyte function, and platelet aggregation. My lab studies eNOS and related signaling pathways using biochemical and cellular imaging approaches in cultured cell systems and in mouse models of cardiovascular disease. We are using novel biosensors to understand the roles of reactive oxygen species in modifying eNOS signaling in cardiovascular physiology and pathophysiology. We also are exploring the roles of “statin” drugs (HMG CoA reductase inhibitors commonly used in the treatment of cardiovascular disease) on the targeting and protein associations of eNOS. Student research projects in my lab involve basic investigations into the intracellular pathways that regulate eNOS and related signaling proteins in endothelial cells, cardiac myocytes, and blood platelets.

Available: 05/20/14, Expires: 08/31/22

Clinically important cardiovascular drugs such as nitroglycerin are metabolized in the body to form nitric oxide (NO), which exerts important physiological effects in vascular smooth muscle and in other tissues throughout the body. Reactive oxygen species such as hydrogen peroxide (H2O2) can have deleterious effects in the vasculature, but H2O2 also has many important roles in normal vascular homeostasis. The nitric oxide synthases are a family of enzymes that generate NO in the vascular wall, heart, brain, and throughout the body.

Our studies have focused mostly on the endothelial isoform of NO synthase, a versatile enzyme that synthesizes both NO and reactive oxygen species, and which is post-translationally modified by phosphorylation and acylation. NO synthase signaling pathways are impaired in important vascular disease states such as diabetes and atherosclerosis. Statins importantly impact NO synthase activity and abundance, as well as both NO and H2O2 metabolism. Our laboratory is exploring NO-related signaling pathways in vascular endothelium and cardiac myocytes. We have a variety of ongoing research projects that explore the relationship between NO and H2O2 signaling in normal cells and in disease models including diabetes.

Over the years, many medical students have pursued summer research projects in our lab, in several cases leading to medical school theses. Students with a background in biochemistry and cell biology who are seeking to pursue basic research into a fascinating signaling system with direct relevance to cardiovascular pathobiology are encouraged to read papers from our lab and to inquire about pursuing research studies here.

Analysis of the Roles of Nitric Oxide and Nitric Oxide Synthases in Apoptosis
Summer, 05/22/00 - 08/31/00

Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21AG063073 (MICHEL, THOMAS) Apr 15, 2019 - Jan 31, 2021
    NIH/NIA
    Chemogenetic approaches to define the roles of redox dysfunction in the cardiomyopathy of aging
    Role: Principal Investigator
  2. TL1TR002543 (MICHEL, THOMAS) May 1, 2018 - Apr 30, 2023
    NIH/NCATS
    NRSA Training Core
    Role: Principal Investigator
  3. R01GM036259 (MICHEL, THOMAS) Aug 24, 2009 - Jun 30, 2006
    NIH/NIGMS
    Protein interactions in cardiovascular signaling
    Role: Principal Investigator
  4. P01HL048743 (MICHEL, THOMAS) Sep 2, 1997 - Sep 29, 1999
    NIH/NHLBI
    Arterial Dysfunction: Basic and Clinical Mechanisms
    Role: Principal Investigator
  5. P50HL052320 (SEIDMAN, CHRISTINE E.) Jan 15, 1995 - Jan 31, 2006
    NIH/NHLBI
    SPECIALIZED CENTER OF RESEARCH IN HEART FAILURE
    Role: Co-Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Saeedi Saravi SS, Eroglu E, Waldeck-Weiermair M, Sorrentino A, Steinhorn B, Belousov V, Michel T. Differential endothelial signaling responses elicited by chemogenetic H2O2 synthesis. Redox Biol. 2020 Jun 16; 36:101605. PMID: 32590330.
    Citations:    
  2. Sorrentino A, Michel T. Redox à la carte: Novel chemogenetic models of heart failure. Br J Pharmacol. 2020 Jul; 177(14):3162-3167. PMID: 32368791.
    Citations:    
  3. Hollenhorst MA, Braun DA, Burtner CR, Cajigas I, Cunningham-Bussel AC, Eser PÖ, Nabel CS, Tsai FD, Weeks LD, Michel T, Yialamas MA. Bridging the Divide: Student Grand Rounds at the Interface of Basic Science and Clinical Medicine. Acad Med. 2020 04; 95(4):548-552. PMID: 31833852.
    Citations:    
  4. Vaduganathan M, Vardeny O, Michel T, McMurray JJV, Pfeffer MA, Solomon SD. Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19. N Engl J Med. 2020 04 23; 382(17):1653-1659. PMID: 32227760.
    Citations:    
  5. Eroglu E, Saravi SSS, Sorrentino A, Steinhorn B, Michel T. Discordance between eNOS phosphorylation and activation revealed by multispectral imaging and chemogenetic methods. Proc Natl Acad Sci U S A. 2019 10 01; 116(40):20210-20217. PMID: 31527268.
    Citations:    
  6. Sorrentino A, Steinhorn B, Troncone L, Saravi SSS, Badole S, Eroglu E, Kijewski MF, Divakaran S, Di Carli M, Michel T. Reversal of heart failure in a chemogenetic model of persistent cardiac redox stress. Am J Physiol Heart Circ Physiol. 2019 09 01; 317(3):H617-H626. PMID: 31298558.
    Citations:    
  7. Mishina NM, Bogdanova YA, Ermakova YG, Panova AS, Kotova DA, Bilan DS, Steinhorn B, Arnér ESJ, Michel T, Belousov VV. Which Antioxidant System Shapes Intracellular H2O2 Gradients? Antioxid Redox Signal. 2019 09 20; 31(9):664-670. PMID: 30864831.
    Citations:    
  8. Steinhorn B, Sorrentino A, Badole S, Bogdanova Y, Belousov V, Michel T. Chemogenetic generation of hydrogen peroxide in the heart induces severe cardiac dysfunction. Nat Commun. 2018 10 02; 9(1):4044. PMID: 30279532.
    Citations:    Fields:    Translation:AnimalsCells
  9. Steinhorn B, Sartoretto JL, Sorrentino A, Romero N, Kalwa H, Abel ED, Michel T. Insulin-dependent metabolic and inotropic responses in the heart are modulated by hydrogen peroxide from NADPH-oxidase isoforms NOX2 and NOX4. Free Radic Biol Med. 2017 12; 113:16-25. PMID: 28917508.
    Citations: 2     Fields:    Translation:AnimalsCells
  10. Kinlay S, Michel T, Leopold JA. The Future of Vascular Biology and Medicine. Circulation. 2016 Jun 21; 133(25):2603-9. PMID: 27324355.
    Citations: 6     Fields:    Translation:HumansAnimals
  11. Goettsch C, Hutcheson JD, Aikawa M, Iwata H, Pham T, Nykjaer A, Kjolby M, Rogers M, Michel T, Shibasaki M, Hagita S, Kramann R, Rader DJ, Libby P, Singh SA, Aikawa E. Sortilin mediates vascular calcification via its recruitment into extracellular vesicles. J Clin Invest. 2016 Apr 01; 126(4):1323-36. PMID: 26950419.
    Citations: 19     Fields:    Translation:HumansAnimalsCells
  12. Machlus KR, Wu SK, Stumpo DJ, Soussou TS, Paul DS, Campbell RA, Kalwa H, Michel T, Bergmeier W, Weyrich AS, Blackshear PJ, Hartwig JH, Italiano JE. Synthesis and dephosphorylation of MARCKS in the late stages of megakaryocyte maturation drive proplatelet formation. Blood. 2016 Mar 17; 127(11):1468-80. PMID: 26744461.
    Citations: 3     Fields:    Translation:AnimalsCells
  13. Wang L, Hagemann TL, Kalwa H, Michel T, Messing A, Feany MB. Nitric oxide mediates glial-induced neurodegeneration in Alexander disease. Nat Commun. 2015 Nov 26; 6:8966. PMID: 26608817.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  14. Steinhorn BS, Loscalzo J, Michel T. Nitroglycerin and Nitric Oxide--A Rondo of Themes in Cardiovascular Therapeutics. N Engl J Med. 2015 Jul 16; 373(3):277-80. PMID: 26176386.
    Citations: 7     Fields:    Translation:Humans
  15. Kraus BJ, Sartoretto JL, Polak P, Hosooka T, Shiroto T, Eskurza I, Lee SA, Jiang H, Michel T, Kahn BB. Novel role for retinol-binding protein 4 in the regulation of blood pressure. FASEB J. 2015 Aug; 29(8):3133-40. PMID: 25911613.
    Citations: 4     Fields:    Translation:AnimalsCells
  16. Tarrago L, Péterfi Z, Lee BC, Michel T, Gladyshev VN. Monitoring methionine sulfoxide with stereospecific mechanism-based fluorescent sensors. Nat Chem Biol. 2015 May; 11(5):332-8. PMID: 25799144.
    Citations: 13     Fields:    Translation:HumansCells
  17. Barroso M, Florindo C, Kalwa H, Silva Z, Turanov AA, Carlson BA, de Almeida IT, Blom HJ, Gladyshev VN, Hatfield DL, Michel T, Castro R, Loscalzo J, Handy DE. Inhibition of cellular methyltransferases promotes endothelial cell activation by suppressing glutathione peroxidase 1 protein expression. J Biol Chem. 2014 May 30; 289(22):15350-62. PMID: 24719327.
    Citations: 5     Fields:    Translation:HumansCells
  18. Kalwa H, Sartoretto JL, Martinelli R, Romero N, Steinhorn BS, Tao M, Ozaki CK, Carman CV, Michel T. Central role for hydrogen peroxide in P2Y1 ADP receptor-mediated cellular responses in vascular endothelium. Proc Natl Acad Sci U S A. 2014 Mar 04; 111(9):3383-8. PMID: 24550450.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  19. Sawada N, Jiang A, Takizawa F, Safdar A, Manika A, Tesmenitsky Y, Kang KT, Bischoff J, Kalwa H, Sartoretto JL, Kamei Y, Benjamin LE, Watada H, Ogawa Y, Higashikuni Y, Kessinger CW, Jaffer FA, Michel T, Sata M, Croce K, Tanaka R, Arany Z. Endothelial PGC-1a mediates vascular dysfunction in diabetes. Cell Metab. 2014 Feb 04; 19(2):246-58. PMID: 24506866.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  20. Shiroto T, Romero N, Sugiyama T, Sartoretto JL, Kalwa H, Yan Z, Shimokawa H, Michel T. Caveolin-1 is a critical determinant of autophagy, metabolic switching, and oxidative stress in vascular endothelium. PLoS One. 2014; 9(2):e87871. PMID: 24498385.
    Citations: 25     Fields:    Translation:AnimalsCells
  21. Michel T. R is for arginine: metabolism of arginine takes off again, in new directions. Circulation. 2013 Sep 24; 128(13):1400-4. PMID: 24004503.
    Citations: 4     Fields:    Translation:HumansAnimals
  22. Ersoy BA, Tarun A, D'Aquino K, Hancer NJ, Ukomadu C, White MF, Michel T, Manning BD, Cohen DE. Phosphatidylcholine transfer protein interacts with thioesterase superfamily member 2 to attenuate insulin signaling. Sci Signal. 2013 Jul 30; 6(286):ra64. PMID: 23901139.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  23. Bretón-Romero R, Kalwa H, Lamas S, Michel T. Role of PTEN in modulation of ADP-dependent signaling pathways in vascular endothelial cells. Biochim Biophys Acta. 2013 Dec; 1833(12):2586-2595. PMID: 23806663.
    Citations: 2     Fields:    Translation:AnimalsCells
  24. Tatematsu S, Francis SA, Natarajan P, Rader DJ, Saghatelian A, Brown JD, Michel T, Plutzky J. Endothelial lipase is a critical determinant of high-density lipoprotein-stimulated sphingosine 1-phosphate-dependent signaling in vascular endothelium. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1788-94. PMID: 23723371.
    Citations: 10     Fields:    Translation:AnimalsCells
  25. Sartoretto JL, Kalwa H, Romero N, Michel T. In vivo imaging of nitric oxide and hydrogen peroxide in cardiac myocytes. Methods Enzymol. 2013; 528:61-78. PMID: 23849859.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  26. Maron BA, Michel T. Subcellular localization of oxidants and redox modulation of endothelial nitric oxide synthase. Circ J. 2012; 76(11):2497-512. PMID: 23075817.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  27. Sartoretto JL, Kalwa H, Shiroto T, Sartoretto SM, Pluth MD, Lippard SJ, Michel T. Role of Ca2+ in the control of H2O2-modulated phosphorylation pathways leading to eNOS activation in cardiac myocytes. PLoS One. 2012; 7(9):e44627. PMID: 22970272.
    Citations: 6     Fields:    Translation:AnimalsCells
  28. Jin BY, Lin AJ, Golan DE, Michel T. MARCKS protein mediates hydrogen peroxide regulation of endothelial permeability. Proc Natl Acad Sci U S A. 2012 Sep 11; 109(37):14864-9. PMID: 22927426.
    Citations: 12     Fields:    Translation:AnimalsCells
  29. Kalwa H, Sartoretto JL, Sartoretto SM, Michel T. Angiotensin-II and MARCKS: a hydrogen peroxide- and RAC1-dependent signaling pathway in vascular endothelium. J Biol Chem. 2012 Aug 17; 287(34):29147-58. PMID: 22773836.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  30. Kou R, Shiroto T, Sartoretto JL, Michel T. Suppression of Gas synthesis by simvastatin treatment of vascular endothelial cells. J Biol Chem. 2012 Jan 20; 287(4):2643-51. PMID: 22144680.
    Citations: 3     Fields:    Translation:AnimalsCells
  31. Sartoretto JL, Kalwa H, Pluth MD, Lippard SJ, Michel T. Hydrogen peroxide differentially modulates cardiac myocyte nitric oxide synthesis. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):15792-7. PMID: 21896719.
    Citations: 33     Fields:    Translation:AnimalsCells
  32. Kalwa H, Michel T. The MARCKS protein plays a critical role in phosphatidylinositol 4,5-bisphosphate metabolism and directed cell movement in vascular endothelial cells. J Biol Chem. 2011 Jan 21; 286(3):2320-30. PMID: 21097841.
    Citations: 24     Fields:    Translation:AnimalsCells
  33. Michel T. NO way to relax: the complexities of coupling nitric oxide synthase pathways in the heart. Circulation. 2010 Feb 02; 121(4):484-6. PMID: 20083685.
    Citations: 8     Fields:    Translation:AnimalsCells
  34. Michel T, Vanhoutte PM. Cellular signaling and NO production. Pflugers Arch. 2010 May; 459(6):807-16. PMID: 20082095.
    Citations: 60     Fields:    Translation:HumansAnimalsCells
  35. Sugiyama T, Michel T. Thiol-metabolizing proteins and endothelial redox state: differential modulation of eNOS and biopterin pathways. Am J Physiol Heart Circ Physiol. 2010 Jan; 298(1):H194-201. PMID: 19897710.
    Citations: 12     Fields:    Translation:AnimalsCells
  36. Hess CN, Kou R, Johnson RP, Li GK, Michel T. ADP signaling in vascular endothelial cells: ADP-dependent activation of the endothelial isoform of nitric-oxide synthase requires the expression but not the kinase activity of AMP-activated protein kinase. J Biol Chem. 2009 Nov 20; 284(47):32209-24. PMID: 19783664.
    Citations: 6     Fields:    Translation:AnimalsCells
  37. Jin BY, Sartoretto JL, Gladyshev VN, Michel T. Endothelial nitric oxide synthase negatively regulates hydrogen peroxide-stimulated AMP-activated protein kinase in endothelial cells. Proc Natl Acad Sci U S A. 2009 Oct 13; 106(41):17343-8. PMID: 19805165.
    Citations: 18     Fields:    Translation:AnimalsCells
  38. Sartoretto JL, Jin BY, Bauer M, Gertler FB, Liao R, Michel T. Regulation of VASP phosphorylation in cardiac myocytes: differential regulation by cyclic nucleotides and modulation of protein expression in diabetic and hypertrophic heart. Am J Physiol Heart Circ Physiol. 2009 Nov; 297(5):H1697-710. PMID: 19734360.
    Citations: 13     Fields:    Translation:AnimalsCells
  39. Kou R, Sartoretto J, Michel T. Regulation of Rac1 by simvastatin in endothelial cells: differential roles of AMP-activated protein kinase and calmodulin-dependent kinase kinase-beta. J Biol Chem. 2009 May 29; 284(22):14734-43. PMID: 19332549.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  40. Sugiyama T, Levy BD, Michel T. Tetrahydrobiopterin recycling, a key determinant of endothelial nitric-oxide synthase-dependent signaling pathways in cultured vascular endothelial cells. J Biol Chem. 2009 May 08; 284(19):12691-700. PMID: 19286667.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  41. Igarashi J, Michel T. Sphingosine-1-phosphate and modulation of vascular tone. Cardiovasc Res. 2009 May 01; 82(2):212-20. PMID: 19233865.
    Citations: 32     Fields:    Translation:HumansAnimals
  42. Kanda T, Brown JD, Orasanu G, Vogel S, Gonzalez FJ, Sartoretto J, Michel T, Plutzky J. PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice. J Clin Invest. 2009 Jan; 119(1):110-24. PMID: 19065047.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  43. Igarashi J, Michel T. S1P and eNOS regulation. Biochim Biophys Acta. 2008 Sep; 1781(9):489-95. PMID: 18638569.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  44. Igarashi J, Michel T. The enigma of sphingosine 1-phosphate synthesis: a novel role for endothelial sphingosine kinases. Circ Res. 2008 Mar 28; 102(6):630-2. PMID: 18369161.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  45. Chen H, Levine YC, Golan DE, Michel T, Lin AJ. Atrial natriuretic peptide-initiated cGMP pathways regulate vasodilator-stimulated phosphoprotein phosphorylation and angiogenesis in vascular endothelium. J Biol Chem. 2008 Feb 15; 283(7):4439-47. PMID: 18079117.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  46. Kou R, Michel T. Epinephrine regulation of the endothelial nitric-oxide synthase: roles of RAC1 and beta3-adrenergic receptors in endothelial NO signaling. J Biol Chem. 2007 Nov 09; 282(45):32719-29. PMID: 17855349.
    Citations: 26     Fields:    Translation:HumansAnimalsCells
  47. Atochin DN, Wang A, Liu VW, Critchlow JD, Dantas AP, Looft-Wilson R, Murata T, Salomone S, Shin HK, Ayata C, Moskowitz MA, Michel T, Sessa WC, Huang PL. The phosphorylation state of eNOS modulates vascular reactivity and outcome of cerebral ischemia in vivo. J Clin Invest. 2007 Jul; 117(7):1961-7. PMID: 17557122.
    Citations: 60     Fields:    Translation:AnimalsCells
  48. Lamas S, Lowenstein CJ, Michel T. Nitric oxide signaling comes of age: 20 years and thriving. Cardiovasc Res. 2007 Jul 15; 75(2):207-9. PMID: 17574221.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  49. Levine YC, Li GK, Michel T. Agonist-modulated regulation of AMP-activated protein kinase (AMPK) in endothelial cells. Evidence for an AMPK -> Rac1 -> Akt -> endothelial nitric-oxide synthase pathway. J Biol Chem. 2007 Jul 13; 282(28):20351-64. PMID: 17519230.
    Citations: 74     Fields:    Translation:AnimalsCells
  50. Dudzinski DM, Michel T. Life history of eNOS: partners and pathways. Cardiovasc Res. 2007 Jul 15; 75(2):247-60. PMID: 17466957.
    Citations: 144     Fields:    Translation:HumansAnimalsCells
  51. Lowenstein CJ, Michel T. What's in a name? eNOS and anaphylactic shock. J Clin Invest. 2006 Aug; 116(8):2075-8. PMID: 16886052.
    Citations: 10     Fields:    Translation:HumansAnimals
  52. Chen H, Michel T. Insulin signaling in vascular endothelial cells: a key role for heterotrimeric G proteins revealed by siRNA-mediated Gbeta1 knockdown. Biochemistry. 2006 Jul 04; 45(26):8023-33. PMID: 16800627.
    Citations: 1     Fields:    Translation:AnimalsCells
  53. Dudzinski D, Igarashi J, Greif D, Michel T. Pharmacology and molecular regulation of nitric oxide synthases. Annu Rev Pharmacol Toxicol. 2006; 46:235-76.
  54. Gonzalez E, Kou R, Michel T. Rac1 and modulation of P13-kinase pathwaysi n vascular endothelial cells. J Biol Chem. 2006; 281:3210-6.
  55. Michel T. Molecule Page: endothelial nitric oxide synthase. Alliance for Cell Signaling/Nature Publishing. 2006.
  56. Dudzinski DM, Igarashi J, Greif D, Michel T. The regulation and pharmacology of endothelial nitric oxide synthase. Annu Rev Pharmacol Toxicol. 2006; 46:235-76. PMID: 16402905.
    Citations: 117     Fields:    Translation:HumansAnimals
  57. Dudzinski D, Michel T. Vascular biology of nitric oxide and NO synthases. L Clowes, ed. Hemostasis and Thrombosis. 2006; 653-67.
  58. Michel T. Molecule Page: caveolin-3. Alliance for Cell Signaling/Nature Publishing. 2006.
  59. Mitchell DA, Michel T, Marletta M. S-nitrosylation of nitric oxide synthases. Adv Exp Biol. 2006.
  60. Gonzalez E, Kou R, Michel T. Rac1 modulates sphingosine 1-phosphate-mediated activation of phosphoinositide 3-kinase/Akt signaling pathways in vascular endothelial cells. J Biol Chem. 2006 Feb 10; 281(6):3210-6. PMID: 16339142.
    Citations: 40     Fields:    Translation:AnimalsCells
  61. Kou R, SenBanerjee S, Jain MK, Michel T. Differential regulation of vascular endothelial growth factor receptors (VEGFR) revealed by RNA interference: interactions of VEGFR-1 and VEGFR-2 in endothelial cell signaling. Biochemistry. 2005 Nov 15; 44(45):15064-73. PMID: 16274253.
    Citations: 9     Fields:    Translation:AnimalsCells
  62. Erwin PA, Mitchell DA, Sartoretto J, Marletta MA, Michel T. Subcellular targeting and differential S-nitrosylation of endothelial nitric-oxide synthase. J Biol Chem. 2006 Jan 06; 281(1):151-7. PMID: 16286475.
    Citations: 40     Fields:    Translation:AnimalsCells
  63. Mitchell DA, Erwin PA, Michel T, Marletta MA. S-Nitrosation and regulation of inducible nitric oxide synthase. Biochemistry. 2005 Mar 29; 44(12):4636-47. PMID: 15779890.
    Citations: 20     Fields:    Translation:AnimalsCells
  64. Erwin PA, Lin AJ, Golan DE, Michel T. Receptor-regulated dynamic S-nitrosylation of endothelial nitric-oxide synthase in vascular endothelial cells. J Biol Chem. 2005 May 20; 280(20):19888-94. PMID: 15774480.
    Citations: 82     Fields:    Translation:AnimalsCells
  65. Michel T. Treatment of myocardial eschemia. L Brunton, ed. Goodman and Gilman's Pharmacological Basis of Therapeutics. 2005; 823-44.
  66. Gonzalez E, Nagiel A, Lin AJ, Golan DE, Michel T. Small interfering RNA-mediated down-regulation of caveolin-1 differentially modulates signaling pathways in endothelial cells. J Biol Chem. 2004 Sep 24; 279(39):40659-69. PMID: 15292187.
    Citations: 46     Fields:    Translation:AnimalsCells
  67. SenBanerjee S, Lin Z, Atkins GB, Greif DM, Rao RM, Kumar A, Feinberg MW, Chen Z, Simon DI, Luscinskas FW, Michel TM, Gimbrone MA, García-Cardeña G, Jain MK. KLF2 Is a novel transcriptional regulator of endothelial proinflammatory activation. J Exp Med. 2004 May 17; 199(10):1305-15. PMID: 15136591.
    Citations: 182     Fields:    Translation:HumansCells
  68. Greif DM, Sacks DB, Michel T. Calmodulin phosphorylation and modulation of endothelial nitric oxide synthase catalysis. Proc Natl Acad Sci U S A. 2004 Feb 03; 101(5):1165-70. PMID: 14736917.
    Citations: 10     Fields:    Translation:AnimalsCells
  69. Yeh DC, Michel T. Pharmacology of Vascular Tone. DE Golan et al, eds. Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy. 2004; 317-34.
  70. Jobin CM, Chen H, Lin AJ, Yacono PW, Igarashi J, Michel T, Golan DE. Receptor-regulated dynamic interaction between endothelial nitric oxide synthase and calmodulin revealed by fluorescence resonance energy transfer in living cells. Biochemistry. 2003 Oct 14; 42(40):11716-25. PMID: 14529282.
    Citations: 6     Fields:    Translation:AnimalsCells
  71. Igarashi J, Erwin PA, Dantas AP, Chen H, Michel T. VEGF induces S1P1 receptors in endothelial cells: Implications for cross-talk between sphingolipid and growth factor receptors. Proc Natl Acad Sci U S A. 2003 Sep 16; 100(19):10664-9. PMID: 12963813.
    Citations: 65     Fields:    Translation:AnimalsCells
  72. Dantas AP, Igarashi J, Michel T. Sphingosine 1-phosphate and control of vascular tone. Am J Physiol Heart Circ Physiol. 2003 Jun; 284(6):H2045-52. PMID: 12742827.
    Citations: 31     Fields:    Translation:AnimalsCells
  73. Thatte HS, Biswas KS, Najjar SF, Birjiniuk V, Crittenden MD, Michel T, Khuri SF. Multi-photon microscopic evaluation of saphenous vein endothelium and its preservation with a new solution, GALA. Ann Thorac Surg. 2003 Apr; 75(4):1145-52; discussion 1152. PMID: 12683553.
    Citations: 8     Fields:    Translation:Humans
  74. Greif DM, Kou R, Michel T. Site-specific dephosphorylation of endothelial nitric oxide synthase by protein phosphatase 2A: evidence for crosstalk between phosphorylation sites. Biochemistry. 2002 Dec 31; 41(52):15845-53. PMID: 12501214.
    Citations: 36     Fields:    Translation:AnimalsCells
  75. Gonzalez E, Kou R, Lin AJ, Golan DE, Michel T. Subcellular targeting and agonist-induced site-specific phosphorylation of endothelial nitric-oxide synthase. J Biol Chem. 2002 Oct 18; 277(42):39554-60. PMID: 12189156.
    Citations: 32     Fields:    Translation:AnimalsCells
  76. Kou R, Greif D, Michel T. Dephosphorylation of endothelial nitric-oxide synthase by vascular endothelial growth factor. Implications for the vascular responses to cyclosporin A. J Biol Chem. 2002 Aug 16; 277(33):29669-73. PMID: 12050171.
    Citations: 45     Fields:    Translation:AnimalsCells
  77. Kou R, Igarashi J, Michel T. Lysophosphatidic acid and receptor-mediated activation of endothelial nitric-oxide synthase. Biochemistry. 2002 Apr 16; 41(15):4982-8. PMID: 11939794.
    Citations: 13     Fields:    Translation:AnimalsCells
  78. Aprille JR, Lagace CJ, Lewis SM, Michel T, Modica-Napolitano JS, Trimmer BA, Zayas RM. Mechanism of firefly flash control: NO inhibition of oxygen consumption in lantern mitchondria is reversed by light. Stanley PE and Kricka LJ, eds. Bioluminescence & Chemiluminescence: Progress & Current Applications. 2002; 25-8.
  79. Igarashi J, Michel T. More sweetness than light? A search for the causes of diabetic vasculopathy. J Clin Invest. 2001 Nov; 108(10):1425-7. PMID: 11714733.
    Citations: 3     Fields:    Translation:HumansCells
  80. Rakhit A, Maguire CT, Wakimoto H, Gehrmann J, Li GK, Kelly RA, Michel T, Berul CI. In vivo electrophysiologic studies in endothelial nitric oxide synthase (eNOS)-deficient mice. J Cardiovasc Electrophysiol. 2001 Nov; 12(11):1295-301. PMID: 11761419.
    Citations: 11     Fields:    Translation:Animals
  81. Clapham D, Michel T, Seidman C. In memorium. J Mol Cell Cardiol. 2001 Aug; 33(8):1393-4. PMID: 11448127.
    Citations:    Fields:    Translation:Cells
  82. Igarashi J, Michel T. Sphingosine 1-phosphate and isoform-specific activation of phosphoinositide 3-kinase beta. Evidence for divergence and convergence of receptor-regulated endothelial nitric-oxide synthase signaling pathways. J Biol Chem. 2001 Sep 28; 276(39):36281-8. PMID: 11470796.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  83. Trimmer BA, Aprille JR, Dudzinski DM, Lagace CJ, Lewis SM, Michel T, Qazi S, Zayas RM. Nitric oxide and the control of firefly flashing. Science. 2001 Jun 29; 292(5526):2486-8. PMID: 11431567.
    Citations: 12     Fields:    Translation:AnimalsCells
  84. Navarro-Antolín J, López-Muñoz MJ, Klatt P, Soria J, Michel T, Lamas S. Formation of peroxynitrite in vascular endothelial cells exposed to cyclosporine A. FASEB J. 2001 May; 15(7):1291-3. PMID: 11344117.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  85. Igarashi J, Bernier SG, Michel T. Sphingosine 1-phosphate and activation of endothelial nitric-oxide synthase. differential regulation of Akt and MAP kinase pathways by EDG and bradykinin receptors in vascular endothelial cells. J Biol Chem. 2001 Apr 13; 276(15):12420-6. PMID: 11278407.
    Citations: 56     Fields:    Translation:AnimalsCells
  86. Thatte H, Biswas N, Najjar SF, Rhee JH, Birjuniuk V, Michel T, Khuri S. Multiphoton microscopy in imagining of human saphenous vein. J Surg Res. 2001; 276:36281-8.
  87. Biswas KS, Thatte HS, Najjar SF, Rhee JH, Birjiniuk V, Crittenden MD, Michel T, Khuri SF. Multi-photon microscopy in the evaluation of human saphenous vein. J Surg Res. 2001 Jan; 95(1):37-43. PMID: 11120633.
    Citations: 1     Fields:    Translation:Humans
  88. Finckh U, von der Kammer H, Velden J, Michel T, Andresen B, Deng A, Zhang J, Müller-Thomsen T, Zuchowski K, Menzer G, Mann U, Papassotiropoulos A, Heun R, Zurdel J, Holst F, Benussi L, Stoppe G, Reiss J, Miserez AR, Staehelin HB, Rebeck GW, Hyman BT, Binetti G, Hock C, Growdon JH, Nitsch RM. Genetic association of a cystatin C gene polymorphism with late-onset Alzheimer disease. Arch Neurol. 2000 Nov; 57(11):1579-83. PMID: 11074789.
    Citations: 27     Fields:    Translation:Humans
  89. Igarashi J, Michel T. Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction. J Biol Chem. 2000 Oct 13; 275(41):32363-70. PMID: 10921915.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  90. Bernier SG, Haldar S, Michel T. Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem. 2000 Sep 29; 275(39):30707-15. PMID: 10899167.
    Citations: 38     Fields:    Translation:AnimalsCells
  91. Kubota I, Han X, Opel DJ, Zhao YY, Baliga R, Huang P, Fishman MC, Shannon RP, Michel T, Kelly RA. Increased susceptibility to development of triggered activity in myocytes from mice with targeted disruption of endothelial nitric oxide synthase. J Mol Cell Cardiol. 2000 Jul; 32(7):1239-48. PMID: 10860766.
    Citations: 11     Fields:    Translation:AnimalsCells
  92. Prabhakar P, Cheng V, Michel T. A chimeric transmembrane domain directs endothelial nitric-oxide synthase palmitoylation and targeting to plasmalemmal caveolae. J Biol Chem. 2000 Jun 23; 275(25):19416-21. PMID: 10787410.
    Citations: 18     Fields:    Translation:Cells
  93. Michel T. Impatient inpatient care. N Engl J Med. 2000 Jun 01; 342(22):1678-9. PMID: 10836888.
    Citations:    Fields:    Translation:Humans
  94. Michel T, Weinfeld MS. Stable coronary artery disease: angina and atherosclerosis. Melmon KL et all, eds. Melmon and Morelli's Clinical Pharmacology: Basic Principles in Therapeutics. 2000; 114-31.
  95. Sase K, Michel T. Regulatory mechanisms of endothelial nitric oxide synthase. Yasue H, ed. Coronary Artery Spasm. 2000; 19-25.
  96. Feron O, Michel T. Cell and molecular biology of nitric oxide synthases. J. Loscalzo and J.A. Vita, ed. Nitric Oxide and the Cardiovascular System. 2000; 11-32.
  97. Yeh DC, Duncan JA, Yamashita S, Michel T. Depalmitoylation of endothelial nitric-oxide synthase by acyl-protein thioesterase 1 is potentiated by Ca(2+)-calmodulin. J Biol Chem. 1999 Nov 12; 274(46):33148-54. PMID: 10551886.
    Citations: 53     Fields:    Translation:AnimalsCells
  98. Michel T. Targeting and translocation of endothelial nitric oxide synthase. Braz J Med Biol Res. 1999 Nov; 32(11):1361-6. PMID: 10559837.
    Citations: 12     Fields:    Translation:HumansCells
  99. Igarashi J, Thatte HS, Prabhakar P, Golan DE, Michel T. Calcium-independent activation of endothelial nitric oxide synthase by ceramide. Proc Natl Acad Sci U S A. 1999 Oct 26; 96(22):12583-8. PMID: 10535965.
    Citations: 13     Fields:    Translation:AnimalsCells
  100. Goetz RM, Thatte HS, Prabhakar P, Cho MR, Michel T, Golan DE. Estradiol induces the calcium-dependent translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2788-93. PMID: 10077589.
    Citations: 35     Fields:    Translation:AnimalsCells
  101. Downey W, Michel T. Molecular and cellular regulation of endothelial nitric oxide in synthase. Goodman R and Panda J, eds. Endothelium, nitric oxide and atherosclerosis. 1999; 29-37.
  102. Michel T, Lamas S. Endothelium-derived nitric oxide and the control of vascular tone. Jameson L, ed. Textbook of Molecular Medicine. 1999.
  103. Feron O, Dessy C, Opel DJ, Arstall MA, Kelly RA, Michel T. Modulation of the endothelial nitric-oxide synthase-caveolin interaction in cardiac myocytes. Implications for the autonomic regulation of heart rate. J Biol Chem. 1998 Nov 13; 273(46):30249-54. PMID: 9804784.
    Citations: 39     Fields:    Translation:AnimalsCells
  104. Prabhakar P, Thatte HS, Goetz RM, Cho MR, Golan DE, Michel T. Receptor-regulated translocation of endothelial nitric-oxide synthase. J Biol Chem. 1998 Oct 16; 273(42):27383-8. PMID: 9765266.
    Citations: 32     Fields:    Translation:AnimalsCells
  105. Teng B, Murthy KS, Kuemmerle JF, Grider JR, Sase K, Michel T, Makhlouf GM. Expression of endothelial nitric oxide synthase in human and rabbit gastrointestinal smooth muscle cells. Am J Physiol. 1998 08; 275(2):G342-51. PMID: 9688662.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  106. Han X, Kubota I, Feron O, Opel DJ, Arstall MA, Zhao YY, Huang P, Fishman MC, Michel T, Kelly RA. Muscarinic cholinergic regulation of cardiac myocyte ICa-L is absent in mice with targeted disruption of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1998 May 26; 95(11):6510-5. PMID: 9600997.
    Citations: 24     Fields:    Translation:AnimalsCells
  107. Feron O, Saldana F, Michel JB, Michel T. The endothelial nitric-oxide synthase-caveolin regulatory cycle. J Biol Chem. 1998 Feb 06; 273(6):3125-8. PMID: 9452418.
    Citations: 77     Fields:    Translation:AnimalsCells
  108. Feron O, Michel JB, Sase K, Michel T. Dynamic regulation of endothelial nitric oxide synthase: complementary roles of dual acylation and caveolin interactions. Biochemistry. 1998 Jan 06; 37(1):193-200. PMID: 9425039.
    Citations: 29     Fields:    Translation:AnimalsCells
  109. Michel T, Feron O. Nitric oxide synthases: which, where, how, and why? J Clin Invest. 1997 Nov 01; 100(9):2146-52. PMID: 9410890.
    Citations: 168     Fields:    Translation:Cells
  110. Michel JB, Feron O, Sase K, Prabhakar P, Michel T. Caveolin versus calmodulin. Counterbalancing allosteric modulators of endothelial nitric oxide synthase. J Biol Chem. 1997 Oct 10; 272(41):25907-12. PMID: 9325323.
    Citations: 73     Fields:    Translation:AnimalsCells
  111. Feron O, Smith TW, Michel T, Kelly RA. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 1997 Jul 11; 272(28):17744-8. PMID: 9211926.
    Citations: 38     Fields:    Translation:Animals
  112. Michel JB, Feron O, Sacks D, Michel T. Reciprocal regulation of endothelial nitric-oxide synthase by Ca2+-calmodulin and caveolin. J Biol Chem. 1997 Jun 20; 272(25):15583-6. PMID: 9188442.
    Citations: 131     Fields:    Translation:AnimalsCells
  113. Belhassen L, Feron O, Kaye DM, Michel T, Kelly RA. Regulation by cAMP of post-translational processing and subcellular targeting of endothelial nitric-oxide synthase (type 3) in cardiac myocytes. J Biol Chem. 1997 Apr 25; 272(17):11198-204. PMID: 9111020.
    Citations: 7     Fields:    Translation:AnimalsCells
  114. Michel JB, Michel T. The role of palmitoyl-protein thioesterase in the palmitoylation of endothelial nitric oxide synthase. FEBS Lett. 1997 Apr 01; 405(3):356-62. PMID: 9108318.
    Citations: 4     Fields:    Translation:AnimalsCells
  115. Sase K, Michel T. Expression and regulation of endothelial nitric oxide synthase. Trends Cardiovasc Med. 1997; 7:25-34.
  116. Michel T, Sase K, Lamas S. Molecular regulation of nitric oxide synthases. Marks A and Taubman M, eds. Molecular Biology of Cardiovascular Disesase. 1997; 141-60.
  117. Sase K, Michel T. Expression and regulation of endothelial nitric oxide synthase. Trends Cardiovasc Med. 1997 Jan; 7(1):28-37. PMID: 21235861.
    Citations: 14     Fields:    
  118. Smith TW, Balligand JL, Kaye DM, Wiviott SD, Simmons WW, Han X, Michel T, Singh K, Kelly RA. The role of the NO pathway in the control of cardiac function. J Card Fail. 1996 Dec; 2(4 Suppl):S141-7. PMID: 8951572.
    Citations: 5     Fields:    Translation:AnimalsCells
  119. Baum HB, Biller BM, Finkelstein JS, Cannistraro KB, Oppenhein DS, Schoenfeld DA, Michel TH, Wittink H, Klibanski A. Effects of physiologic growth hormone therapy on bone density and body composition in patients with adult-onset growth hormone deficiency. A randomized, placebo-controlled trial. Ann Intern Med. 1996 Dec 01; 125(11):883-90. PMID: 8967668.
    Citations: 40     Fields:    Translation:HumansCTClinical Trials
  120. Feron O, Belhassen L, Kobzik L, Smith TW, Kelly RA, Michel T. Endothelial nitric oxide synthase targeting to caveolae. Specific interactions with caveolin isoforms in cardiac myocytes and endothelial cells. J Biol Chem. 1996 Sep 13; 271(37):22810-4. PMID: 8798458.
    Citations: 135     Fields:    Translation:Animals
  121. Buttery LD, Chester AH, Springall DR, Borland JA, Michel T, Yacoub MH, Polak JM. Explanted vein grafts with an intact endothelium demonstrate reduced focal expression of endothelial nitric oxide synthase specific to atherosclerotic sites. J Pathol. 1996 Jun; 179(2):197-203. PMID: 8758213.
    Citations: 6     Fields:    Translation:Humans
  122. Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, Michel T. Acylation targets emdothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem. 1996 Mar 15; 271(11):6518-22. PMID: 8626455.
    Citations: 138     Fields:    Translation:AnimalsCells
  123. Robinson LJ, Ghanouni P, Michel T. Posttranslational modifications of endothelial nitric oxide synthase. Methods Enzymol. 1996; 268:436-48. PMID: 8782610.
    Citations:    Fields:    Translation:AnimalsCells
  124. Robinson LJ, Michel T. Endothelial nitric oxide synthase expression in heterologous systems. Methods Enzymol. 1996; 269:55-64. PMID: 8791637.
    Citations:    Fields:    Translation:HumansAnimalsCells
  125. Robinson LJ, Morton CC, Michel T. The constitutive endothelial NO synthase gene: implications for its evolution and cellular regulation. S. Moncada, ed. The biology of nitrix oxide. 1996; 1-4.
  126. Michel T, Xie QW, Nathan C. Molecular biological analysis of nitric oxide synthases. Feelisch M and Stamler J (eds.) Methods in Nitric Oxide Research. 1996; 161-176.
  127. Lamas S, Michel T. Molecular biological features of the nitric oxide synthases. Zapol W, ed. Nitric Oxide and the Lung. 1996; 59-68.
  128. Robinson LJ, Michel T. Mutagenesis of palmitoylation sites in endothelial nitric oxide synthase identifies a novel motif for dual acylation and subcellular targeting. Proc Natl Acad Sci U S A. 1995 Dec 05; 92(25):11776-80. PMID: 8524847.
    Citations: 28     Fields:    Translation:Cells
  129. Lee CM, Robinson LJ, Michel T. Oligomerization of endothelial nitric oxide synthase. Evidence for a dominant negative effect of truncation mutants. J Biol Chem. 1995 Nov 17; 270(46):27403-6. PMID: 7499193.
    Citations: 11     Fields:    Translation:AnimalsCells
  130. Ungureanu-Longrois D, Balligand JL, Okada I, Simmons WW, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res. 1995 Sep; 77(3):486-93. PMID: 7543825.
    Citations: 11     Fields:    Translation:AnimalsCells
  131. Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ Res. 1995 Sep; 77(3):494-502. PMID: 7543826.
    Citations: 11     Fields:    Translation:AnimalsCells
  132. Balligand JL, Kobzik L, Han X, Kaye DM, Belhassen L, O'Hara DS, Kelly RA, Smith TW, Michel T. Nitric oxide-dependent parasympathetic signaling is due to activation of constitutive endothelial (type III) nitric oxide synthase in cardiac myocytes. J Biol Chem. 1995 Jun 16; 270(24):14582-6. PMID: 7540173.
    Citations: 58     Fields:    Translation:AnimalsCells
  133. Busconi L, Michel T. Recombinant endothelial nitric oxide synthase: post-translational modifications in a baculovirus expression system. Mol Pharmacol. 1995 Apr; 47(4):655-9. PMID: 7536885.
    Citations: 5     Fields:    Translation:AnimalsCells
  134. Balligand JL, Ungureanu-Longrois D, Simmons WW, Kobzik L, Lowenstein CJ, Lamas S, Kelly RA, Smith TW, Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1293-303. PMID: 7535006.
    Citations: 16     Fields:    Translation:AnimalsCells
  135. Robinson LJ, Busconi L, Michel T. Agonist-modulated palmitoylation of endothelial nitric oxide synthase. J Biol Chem. 1995 Jan 20; 270(3):995-8. PMID: 7530714.
    Citations: 35     Fields:    Translation:AnimalsCells
  136. Sase K, Michel T. Expression of constitutive endothelial nitric oxide synthase in human blood platelets. Life Sci. 1995; 57(22):2049-55. PMID: 7475956.
    Citations: 21     Fields:    Translation:HumansCells
  137. Michel TH. Should physical therapists treat pain or dysfunction? What is the primary treatment goal? Scand J Rehabil Med Suppl. 1995; 32:79. PMID: 7784841.
    Citations:    Fields:    Translation:Humans
  138. Shaul PW, North AJ, Wu LC, Wells LB, Brannon TS, Lau KS, Michel T, Margraf LR, Star RA. Endothelial nitric oxide synthase is expressed in cultured human bronchiolar epithelium. J Clin Invest. 1994 Dec; 94(6):2231-6. PMID: 7527428.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  139. Busconi L, Michel T. Endothelial nitric oxide synthase membrane targeting. Evidence against involvement of a specific myristate receptor. J Biol Chem. 1994 Oct 07; 269(40):25016-20. PMID: 7523377.
    Citations: 6     Fields:    Translation:AnimalsCells
  140. Buttery LD, McCarthy A, Springall DR, Sullivan MH, Elder MG, Michel T, Polak JM. Endothelial nitric oxide synthase in the human placenta: regional distribution and proposed regulatory role at the feto-maternal interface. Placenta. 1994 Apr; 15(3):257-65. PMID: 7520584.
    Citations: 11     Fields:    Translation:HumansCells
  141. Robinson LJ, Weremowicz S, Morton CC, Michel T. Isolation and chromosomal localization of the human endothelial nitric oxide synthase (NOS3) gene. Genomics. 1994 Jan 15; 19(2):350-7. PMID: 7514568.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  142. Balligand JL, Ungureaunu-Longrois D, Simmons W, Lowenstein C, Malinski T, Kelly RA, Smith TW, Michel T. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes: characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem. 1994; 169:27580-8.
  143. Michel T, Smith TW. Nitric oxide synthases and cardiovascular signaling. Am J Cardiol. 1993 Sep 09; 72(8):33C-38C. PMID: 7690516.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  144. Michel T, Li GK, Busconi L. Phosphorylation and subcellular translocation of endothelial nitric oxide synthase. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6252-6. PMID: 7687064.
    Citations: 67     Fields:    Translation:AnimalsCells
  145. Balligand JL, Ungureanu D, Kelly RA, Kobzik L, Pimental D, Michel T, Smith TW. Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium. J Clin Invest. 1993 May; 91(5):2314-9. PMID: 8486792.
    Citations: 60     Fields:    Translation:AnimalsCells
  146. Busconi L, Michel T. Endothelial nitric oxide synthase. N-terminal myristoylation determines subcellular localization. J Biol Chem. 1993 Apr 25; 268(12):8410-3. PMID: 7682550.
    Citations: 41     Fields:    Translation:AnimalsCells
  147. Michel T. No lack of NO activity. Science. 1993 Apr 09; 260(5105):146. PMID: 8469964.
    Citations:    Fields:    Translation:Humans
  148. Michel T. The guide to politically correct cardiology. J Irreprod Results. 1993; 38:7-8.
  149. Balligand JL, Kelly RA, Marsden PA, Smith TW, Michel T. Control of cardiac muscle cell function by an endogenous nitric oxide signaling system. Proc Natl Acad Sci U S A. 1993 Jan 01; 90(1):347-51. PMID: 7678347.
    Citations: 117     Fields:    Translation:AnimalsCells
  150. Michel T. Nitric oxide synthesis in infantile hypertrophic pyloric stenosis. N Engl J Med. 1992 Dec 03; 327(23):1690-1. PMID: 1279425.
    Citations: 2     Fields:    Translation:Humans
  151. Lamas S, Michel T, Collins T, Brenner BM, Marsden PA. Effects of interferon-gamma on nitric oxide synthase activity and endothelin-1 production by vascular endothelial cells. J Clin Invest. 1992 Sep; 90(3):879-87. PMID: 1381725.
    Citations: 17     Fields:    Translation:AnimalsCells
  152. Marsden PA, Schappert KT, Chen HS, Flowers M, Sundell CL, Wilcox JN, Lamas S, Michel T. Molecular cloning and characterization of human endothelial nitric oxide synthase. FEBS Lett. 1992 Aug 03; 307(3):287-93. PMID: 1379542.
    Citations: 66     Fields:    Translation:HumansAnimalsCells
  153. Lamas S, Marsden PA, Li GK, Tempst P, Michel T. Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform. Proc Natl Acad Sci U S A. 1992 Jul 15; 89(14):6348-52. PMID: 1378626.
    Citations: 156     Fields:    Translation:AnimalsCells
  154. Willich SN, Tofler GH, Brezinski DA, Schafer AI, Muller JE, Michel T, Colucci WS. Platelet alpha 2 adrenoceptor characteristics during the morning increase in platelet aggregability. Eur Heart J. 1992 Apr; 13(4):550-5. PMID: 1318199.
    Citations: 3     Fields:    Translation:HumansCells
  155. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J. S-nitrosylation of proteins with nitric oxide: synthesis and characterization of biologically active compounds. Proc Natl Acad Sci U S A. 1992 Jan 01; 89(1):444-8. PMID: 1346070.
    Citations: 251     Fields:    Translation:Animals
  156. Michel T, Lamas S. Molecular cloning of constitutive endothelial nitric oxide synthase: evidence for a family of related genes. J Cardiovasc Pharmacol. 1992; 20 Suppl 12:S45-9. PMID: 1282983.
    Citations: 4     Fields:    Translation:AnimalsCells
  157. Michel TH. Outcome assessment in cardiac rehabilitation. Int J Technol Assess Health Care. 1992; 8(1):76-84. PMID: 1601596.
    Citations:    Fields:    Translation:Humans
  158. Michel T, Kramer KB, Kelly RA. Endothelial cell-derived vasoactive and inotropic paracrine factors. Gwathmey J, ed. Therapy of Heart Failure: Basic Science and Clinical Aspects. 1992; 515-36.
  159. Cui Z, Zubiaur M, Bloch DB, Michel T, Seidman JG, Neer EJ. Expression of a G protein subunit, alpha i-1, in Balb/c 3T3 cells leads to agonist-specific changes in growth regulation. J Biol Chem. 1991 Oct 25; 266(30):20276-82. PMID: 1939086.
    Citations: 2     Fields:    Translation:AnimalsCells
  160. Lamas S, Michel T, Brenner BM, Marsden PA. Nitric oxide synthesis in endothelial cells: evidence for a pathway inducible by TNF-alpha. Am J Physiol. 1991 Oct; 261(4 Pt 1):C634-41. PMID: 1656767.
    Citations: 30     Fields:    Translation:Animals
  161. Wolff MS, Michel TH, Krebs DE, Watts NT. Chronic pain--assessment of orthopedic physical therapists' knowledge and attitudes. Phys Ther. 1991 Mar; 71(3):207-14. PMID: 2000436.
    Citations: 1     Fields:    Translation:Humans
  162. Silbert S, Michel T, Lee R, Neer EJ. Differential degradation rates of the G protein alpha o in cultured cardiac and pituitary cells. J Biol Chem. 1990 Feb 25; 265(6):3102-5. PMID: 2105942.
    Citations: 5     Fields:    Translation:AnimalsCells
  163. Ridker PM, Michel T. Streptokinase therapy and cholesterol embolization. Am J Med. 1989 Sep; 87(3):357-8. PMID: 2773974.
    Citations: 3     Fields:    Translation:Humans
  164. Neer EJ, Michel T, Eddy R, Shows T, Seidman JG. Genes for two homologous G-protein alpha subunits map to different human chromosomes. Hum Genet. 1987 Nov; 77(3):259-62. PMID: 2824334.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  165. Michel T, Winslow JW, Smith JA, Seidman JG, Neer EJ. Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Proc Natl Acad Sci U S A. 1986 Oct; 83(20):7663-7. PMID: 3094012.
    Citations: 15     Fields:    Translation:Cells
  166. García-Sáinz JA, Boyer JL, Michel T, Sawyer D, Stiles GL, Dohlman H, Lefkowitz RJ. Effect of pertussis toxin on alpha 2-adrenoceptors: decreased formation of the high-affinity state for agonists. FEBS Lett. 1984 Jun 25; 172(1):95-8. PMID: 6329826.
    Citations: 5     Fields:    Translation:AnimalsCells
  167. Nambi P, Sibley DR, Stadel JM, Michel T, Peters JR, Lefkowitz RJ. Cell-free desensitization of catecholamine-sensitive adenylate cyclase. Agonist- and cAMP-promoted alterations in turkey erythrocyte beta-adrenergic receptors. J Biol Chem. 1984 Apr 10; 259(7):4629-33. PMID: 6323481.
    Citations: 5     Fields:    Translation:AnimalsCells
  168. Lefkowitz RJ, Michel T. Plasma membrane receptors. J Clin Invest. 1983 Oct; 72(4):1185-9. PMID: 6313753.
    Citations: 7     Fields:    Translation:HumansCells
  169. Michel T, Lefkowitz RJ. Hormonal inhibition of adenylate cyclase. alpha 2 Adrenergic receptors promote release of [3H]guanylylimidodiphosphate from platelet membranes. J Biol Chem. 1982 Nov 25; 257(22):13557-63. PMID: 6292195.
    Citations: 6     Fields:    Translation:HumansCells
  170. Lefkowitz RJ, Caron MG, Michel T, Stadel JM. Mechanisms of hormone receptor-effector coupling: the beta-adrenergic receptor and adenylate cyclase. Fed Proc. 1982 Aug; 41(10):2664-70. PMID: 6125416.
    Citations: 12     Fields:    Translation:AnimalsCells
  171. Hoffman BB, Michel T, Brenneman TB, Lefkowitz RJ. Interactions of agonists with platelet alpha 2-adrenergic receptors. Endocrinology. 1982 Mar; 110(3):926-32. PMID: 6120077.
    Citations: 20     Fields:    Translation:HumansCells
  172. Michel T, Hoffman BB, Lefkowitz RJ. Regulation of adenylate cyclase by adrenergic receptors. Litwack G, ed. Biochemical Actions of Hormones. 1982; IX:43-68.
  173. Michel T, Hoffman BB, Lefkowitz RJ, Caron MG. Different sedimentation properties of agonist- and antagonist-labelled platelet alpha 2 adrenergic receptors. Biochem Biophys Res Commun. 1981 Jun 16; 100(3):1131-6. PMID: 6268079.
    Citations: 5     Fields:    Translation:HumansCells
  174. Lefkowitz RJ, De Lean A, Hoffman BB, Stadel JM, Kent R, Michel T, Limbird L. Molecular pharmacology of adenylate cyclase-coupled alpha- and beta-adrenergic receptors. Adv Cyclic Nucleotide Res. 1981; 14:145-61. PMID: 6269377.
    Citations: 5     Fields:    Translation:AnimalsCells
  175. Michel T, Hoffman BB, Lefkowitz RJ. Differential regulation of the alpha 2-adrenergic receptor by Na+ and guanine nucleotides. Nature. 1980 Dec 25; 288(5792):709-11. PMID: 6256638.
    Citations: 21     Fields:    Translation:AnimalsCells
  176. Hoffman BB, Michel T, Kilpatrick DM, Lefkowitz RJ, Tolbert ME, Gilman H, Fain JN. Agonist versus antagonist binding to alpha-adrenergic receptors. Proc Natl Acad Sci U S A. 1980 Aug; 77(8):4569-73. PMID: 6107908.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  177. Lewis SM, D'Asaro EA and Michel T. . Squam Lakes Study Report. Harvard Lake Study, Division of Engineering and Applied Physics. 1976; 102pp.
  178. Michel J, Michel T, Bossert WH. . Identification and mathematical modeling of basic transport processes in eutrophic lake systems. Harvard Lake Study,Division of Engineering and Applied Physics. 1976; 135pp.
  179. Michel TM, Legator MS. DNA repair synthesis and chromosomal aberrations induced in vivo by triethylenemelamine. Mutat Res. 1974 Jul; 24(1):41-5. PMID: 4843975.
    Citations: 1     Fields:    Translation:AnimalsCells
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Physical Neighbors
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.