Harvard Catalyst Profiles

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Antonis A. Armoundas, Ph.D.

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Cardiac Electrophysiology[login at prompt]
Available: 06/09/18, Expires: 08/31/21

Cardiovascular group in the Massachusetts General Hospital (Harvard Medical School and the Division of Health Sciences and Technology) is seeking multiple qualified and enthusiastic students interested in experimental and computational cardiac electrophysiology (cell to organ).

Projects are student-specific, please contact for more details.

Available: 04/21/17, Expires: 11/30/23

Cardiovascular group in the Massachusetts General Hospital (Harvard Medical School) is seeking multiple qualified and enthusiastic students interested in experimental and computational cardiac electrophysiology.

Projects are student specific, please contact for more details.
Lab Mission: To use experimental and computational approaches to study the mechanisms of cardiac arrhythmias from the myocyte to the whole organ level

Research Area I: The project involves participating in clinical trials currently underway in the Division of Cardiology at Massachusetts General Hospital, with the intent to diagnose, prevent or treat atrial or ventricular arrhythmias. The prospective applicant will also participate in developing and/or employing signal processing tools of electrocardiographic signals.

Research Area II: The prospective applicant will be performing experiments in cardiac myocytes using state-of-the-art methodologies, including whole-cell patch-clamping and fluorescence imaging, aiming in (i) improving our understanding of the patho-physiology of myocytes from failing hearts and (ii) designing novel therapies to slow or inhibit the progression of the disease.

Development of a Smart-Phone based Application to Estimate Repolarization Alternans
Summer, 06/08/15 - 07/31/15

The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R21EB026164 (ARMOUNDAS, ANTONIS A) Aug 21, 2020 - Jun 30, 2021
    A Medical-Grade Smart-Phone Based Monitoring System
    Role: Principal Investigator
  2. R21HL137870 (ARMOUNDAS, ANTONIS A) Aug 1, 2017 - Jun 30, 2020
    Utility of Vagal Stimulation to Prevent the Onset of Ventricular Arrhythmias
    Role: Principal Investigator
  3. R01HL135335 (ARMOUNDAS, ANTONIS A) Dec 20, 2016 - Nov 30, 2021
    Prevention and Treatment of Ventricular Tachyarrhythmias
    Role: Principal Investigator
  4. R01HL103961 (ARMOUNDAS, ANTONIS A) Aug 15, 2010 - May 31, 2015
    Method for guiding ablative therapy of cardiac arrythmias
    Role: Principal Investigator
  5. R21AG035128 (ARMOUNDAS, ANTONIS A) Aug 1, 2010 - Jul 31, 2013
    Advanced Pacing Methods for Treating Heart Rhythm Disturbances
    Role: Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Kulkarni K, Awasthi N, Roberts JD, Armoundas AA. Utility of a Smartphone-Based System (cvrPhone) in Estimating Minute Ventilation from Electrocardiographic Signals. Telemed J E Health. 2021 Mar 15. PMID: 33729001.
    Citations:    Fields:    
  2. Lv W, Barrett CD, Arai T, Bapat A, Armoundas AA, Cohen RJ, Lee K. Use of the inverse solution guidance algorithm method for RF ablation catheter guidance. J Cardiovasc Electrophysiol. 2021 Feb 24. PMID: 33625757.
    Citations:    Fields:    
  3. Bazoukis G, Stavrakis S, Zhou J, Bollepalli SC, Tse G, Zhang Q, Singh JP, Armoundas AA. Machine learning versus conventional clinical methods in guiding management of heart failure patients-a systematic review. Heart Fail Rev. 2021 Jan; 26(1):23-34. PMID: 32720083.
    Citations:    Fields:    
  4. Zhang Q, Arney D, Goldman JM, Isselbacher EM, Armoundas AA. Design Implementation and Evaluation of a Mobile Continuous Blood Oxygen Saturation Monitoring System. Sensors (Basel). 2020 Nov 18; 20(22). PMID: 33217945.
    Citations:    Fields:    
  5. Merchant FM, Sayadi O, Sohn K, Weiss EH, Puppala D, Doddamani R, Singh JP, Heist EK, Owen C, Kulkarni K, Armoundas AA. Real-Time Closed-Loop Suppression of Repolarization Alternans Reduces Arrhythmia Susceptibility In Vivo. Circ Arrhythm Electrophysiol. 2020 06; 13(6):e008186. PMID: 32434448.
    Citations:    Fields:    Translation:Animals
  6. Stavrakis S, Kulkarni K, Singh JP, Katritsis DG, Armoundas AA. Autonomic Modulation of Cardiac Arrhythmias: Methods to Assess Treatment and Outcomes. JACC Clin Electrophysiol. 2020 05; 6(5):467-483. PMID: 32439031.
    Citations: 3     Fields:    
  7. Sana F, Isselbacher EM, Singh JP, Heist EK, Pathik B, Armoundas AA. Wearable Devices for Ambulatory Cardiac Monitoring: JACC State-of-the-Art Review. J Am Coll Cardiol. 2020 04 07; 75(13):1582-1592. PMID: 32241375.
    Citations: 9     Fields:    Translation:Humans
  8. Liu B, Lou Q, Smith H, Velez-Cortes F, Dillmann WH, Knollmann BC, Armoundas AA, Györke S. Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias. Int J Mol Sci. 2020 Apr 05; 21(7). PMID: 32260593.
    Citations: 1     Fields:    Translation:AnimalsCells
  9. Vetter L, Cortassa S, O'Rourke B, Armoundas AA, Bedja D, Jende JME, Bendszus M, Paolocci N, Sollot SJ, Aon MA, Kurz FT. Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality. Front Physiol. 2020; 11:175. PMID: 32210835.
    Citations: 1     
  10. Sevakula RK, Au-Yeung WM, Singh JP, Heist EK, Isselbacher EM, Armoundas AA. State-of-the-Art Machine Learning Techniques Aiming to Improve Patient Outcomes Pertaining to the Cardiovascular System. J Am Heart Assoc. 2020 02 18; 9(4):e013924. PMID: 32067584.
    Citations: 4     Fields:    Translation:Humans
  11. Kulkarni K, Merchant FM, Kassab MB, Sana F, Moazzami K, Sayadi O, Singh JP, Heist EK, Armoundas AA. Cardiac Alternans: Mechanisms and Clinical Utility in Arrhythmia Prevention. J Am Heart Assoc. 2019 11 05; 8(21):e013750. PMID: 31617437.
    Citations: 1     Fields:    Translation:HumansCells
  12. Sohn K, Dalvin SP, Merchant FM, Kulkarni K, Sana F, Abohashem S, Singh JP, Heist EK, Owen C, Isselbacher EM, Armoundas AA. Utility of a Smartphone Based System (cvrPhone) to Predict Short-term Arrhythmia Susceptibility. Sci Rep. 2019 10 10; 9(1):14497. PMID: 31601824.
    Citations: 3     Fields:    Translation:HumansAnimals
  13. Au-Yeung WM, Sahani AK, Isselbacher EM, Armoundas AA. Reduction of false alarms in the intensive care unit using an optimized machine learning based approach. NPJ Digit Med. 2019; 2:86. PMID: 31508497.
    Citations: 1     
  14. Lv W, Lee K, Arai T, Barrett CD, Hasan MM, Hayward AM, Marini RP, Barley ME, Galea A, Hirschman G, Armoundas AA, Cohen RJ. Accuracy of cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm to identify sites of origin of cardiac electrical activation. J Interv Card Electrophysiol. 2020 Sep; 58(3):323-331. PMID: 31456103.
    Citations:    Fields:    
  15. Sohn K, Merchant FM, Abohashem S, Kulkarni K, Singh JP, Heist EK, Owen C, Roberts JD, Isselbacher EM, Sana F, Armoundas AA. Utility of a smartphone based system (cvrphone) to accurately determine apneic events from electrocardiographic signals. PLoS One. 2019; 14(6):e0217217. PMID: 31206522.
    Citations: 2     Fields:    Translation:Animals
  16. Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Assessing Spatiotemporal and Functional Organization of Mitochondrial Networks. Methods Mol Biol. 2018; 1782:383-402. PMID: 29851013.
    Citations: 4     Fields:    Translation:AnimalsCells
  17. Sohn K, Merchant FM, Sayadi O, Puppala D, Doddamani R, Sahani A, Singh JP, Heist EK, Isselbacher EM, Armoundas AA. A Novel Point-of-Care Smartphone Based System for Monitoring the Cardiac and Respiratory Systems. Sci Rep. 2017 03 22; 7:44946. PMID: 28327645.
    Citations: 6     Fields:    Translation:HumansAnimals
  18. Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Functional Implications of Cardiac Mitochondria Clustering. Adv Exp Med Biol. 2017; 982:1-24. PMID: 28551779.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  19. Akhbari M, Shamsollahi MB, Sayadi O, Armoundas AA, Jutten C. ECG segmentation and fiducial point extraction using multi hidden Markov model. Comput Biol Med. 2016 12 01; 79:21-29. PMID: 27744177.
    Citations: 2     Fields:    Translation:HumansAnimals
  20. Kurz FT, Kembro JM, Flesia AG, Armoundas AA, Cortassa S, Aon MA, Lloyd D. Network dynamics: quantitative analysis of complex behavior in metabolism, organelles, and cells, from experiments to models and back. Wiley Interdiscip Rev Syst Biol Med. 2017 01; 9(1). PMID: 27599643.
    Citations: 12     Fields:    Translation:HumansAnimalsCells
  21. Radwanski PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S. Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During ß-adrenergic Stimulation. JACC Basic Transl Sci. 2016 Jun; 1(4):251-266. PMID: 27747307.
    Citations: 15     
  22. Breckwoldt MO, Armoundas AA, Aon MA, Bendszus M, O'Rourke B, Schwarzländer M, Dick TP, Kurz FT. Mitochondrial redox and pH signaling occurs in axonal and synaptic organelle clusters. Sci Rep. 2016 Mar 22; 6:23251. PMID: 27000952.
    Citations: 9     Fields:    Translation:AnimalsCells
  23. Stary V, Puppala D, Scherrer-Crosbie M, Dillmann WH, Armoundas AA. SERCA2a upregulation ameliorates cellular alternans induced by metabolic inhibition. J Appl Physiol (1985). 2016 Apr 15; 120(8):865-75. PMID: 26846549.
    Citations: 8     Fields:    Translation:AnimalsCells
  24. Sohn K, Armoundas AA. On the efficiency and accuracy of the single equivalent moving dipole method to identify sites of cardiac electrical activation. Med Biol Eng Comput. 2016 Oct; 54(10):1611-9. PMID: 26798056.
    Citations:    Fields:    Translation:Animals
  25. Akhbari M, Shamsollahi MB, Jutten C, Armoundas AA, Sayadi O. ECG denoising and fiducial point extraction using an extended Kalman filtering framework with linear and nonlinear phase observations. Physiol Meas. 2016 Feb; 37(2):203-26. PMID: 26767425.
    Citations: 2     Fields:    Translation:Humans
  26. Irie T, Sips PY, Kai S, Kida K, Ikeda K, Hirai S, Moazzami K, Jiramongkolchai P, Bloch DB, Doulias PT, Armoundas AA, Kaneki M, Ischiropoulos H, Kranias E, Bloch KD, Stamler JS, Ichinose F. S-Nitrosylation of Calcium-Handling Proteins in Cardiac Adrenergic Signaling and Hypertrophy. Circ Res. 2015 Oct 09; 117(9):793-803. PMID: 26259881.
    Citations: 22     Fields:    Translation:AnimalsCells
  27. Merchant FM, Salerno-Uriarte JA, Caravati F, Falcone S, Molon G, Marangoni D, Raczak G, Danilowicz-Szymanowicz L, Pedretti RF, Sarzi Braga S, Ikeda T, Calo L, Martino A, Erciyes D, Piancastelli M, Maury P, Cohen RJ, Armoundas AA. Prospective Use of Microvolt T-Wave Alternans Testing to Guide Primary Prevention Implantable Cardioverter Defibrillator Therapy. Circ J. 2015; 79(9):1912-9. PMID: 26073692.
    Citations: 4     Fields:    Translation:HumansCTClinical Trials
  28. Thoonen R, Ernande L, Cheng J, Nagasaka Y, Yao V, Miranda-Bezerra A, Chen C, Chao W, Panagia M, Sosnovik DE, Puppala D, Armoundas AA, Hindle A, Bloch KD, Buys ES, Scherrer-Crosbie M. Functional brown adipose tissue limits cardiomyocyte injury and adverse remodeling in catecholamine-induced cardiomyopathy. J Mol Cell Cardiol. 2015 Jul; 84:202-11. PMID: 25968336.
    Citations: 18     Fields:    Translation:AnimalsCells
  29. Kurz FT, Derungs T, Aon MA, O'Rourke B, Armoundas AA. Mitochondrial networks in cardiac myocytes reveal dynamic coupling behavior. Biophys J. 2015 Apr 21; 108(8):1922-33. PMID: 25902432.
    Citations: 15     Fields:    Translation:AnimalsCells
  30. Sayadi O, Puppala D, Ishaque N, Doddamani R, Merchant FM, Barrett C, Singh JP, Heist EK, Mela T, Martínez JP, Laguna P, Armoundas AA. A novel method to capture the onset of dynamic electrocardiographic ischemic changes and its implications to arrhythmia susceptibility. J Am Heart Assoc. 2014 Sep 03; 3(5):e001055. PMID: 25187521.
    Citations: 5     Fields:    Translation:Animals
  31. Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Cardiac mitochondria exhibit dynamic functional clustering. Front Physiol. 2014; 5:329. PMID: 25228884.
    Citations: 8     
  32. Sayadi O, Weiss EH, Merchant FM, Puppala D, Armoundas AA. An optimized method for estimating the tidal volume from intracardiac or body surface electrocardiographic signals: implications for estimating minute ventilation. . 2014 Aug 01; 307(3):H426-36. PMID: 24906917.
    Citations: 8     Translation:Animals
  33. Hucker WJ, Singh JP, Parks K, Armoundas AA. Device-Based Approaches to Modulate the Autonomic Nervous System and Cardiac Electrophysiology. Arrhythm Electrophysiol Rev. 2014 May; 3(1):30-5. PMID: 26835062.
    Citations: 1     
  34. Weiss EH, Sayadi O, Ramaswamy P, Merchant FM, Sajja N, Foley L, Laferriere S, Armoundas AA. An optimized method for the estimation of the respiratory rate from electrocardiographic signals: implications for estimating minute ventilation. . 2014 Aug 01; 307(3):H437-47. PMID: 24858847.
    Citations: 5     Translation:Animals
  35. Sohn K, Lv W, Lee K, Galea A, Hirschman G, Barrett C, Cohen RJ, Armoundas AA. A method to noninvasively identify cardiac bioelectrical sources. Pacing Clin Electrophysiol. 2014 Aug; 37(8):1038-50. PMID: 24645803.
    Citations: 2     Fields:    Translation:Animals
  36. Sohn K, Lv W, Lee K, Galea AM, Hirschman GB, Hayward AM, Cohen RJ, Armoundas AA. The single equivalent moving dipole model does not require spatial anatomical information to determine cardiac sources of activation. IEEE J Biomed Health Inform. 2014 Jan; 18(1):222-30. PMID: 24403420.
    Citations: 1     Fields:    Translation:Animals
  37. Merchant FM, Sayadi O, Puppala D, Moazzami K, Heller V, Armoundas AA. A translational approach to probe the proarrhythmic potential of cardiac alternans: a reversible overture to arrhythmogenesis? . 2014 Feb 15; 306(4):H465-74. PMID: 24322612.
    Citations: 4     Translation:Humans
  38. Merchant FM, Zheng H, Bigger T, Steinman R, Ikeda T, Pedretti RF, Salerno-Uriarte JA, Klersy C, Chan PS, Bartone C, Hohnloser SH, Ruskin JN, Armoundas AA. A combined anatomic and electrophysiologic substrate based approach for sudden cardiac death risk stratification. Am Heart J. 2013 Oct; 166(4):744-52. PMID: 24093856.
    Citations: 4     Fields:    Translation:HumansPHPublic Health
  39. Merchant FM, Sayadi O, Moazzami K, Puppala D, Armoundas AA. T-wave alternans as an arrhythmic risk stratifier: state of the art. Curr Cardiol Rep. 2013 Sep; 15(9):398. PMID: 23881581.
    Citations: 8     Fields:    Translation:Humans
  40. Hobai IA, Buys ES, Morse JC, Edgecomb J, Weiss EH, Armoundas AA, Hou X, Khandelwal AR, Siwik DA, Brouckaert P, Cohen RA, Colucci WS. SERCA Cys674 sulphonylation and inhibition of L-type Ca2+ influx contribute to cardiac dysfunction in endotoxemic mice, independent of cGMP synthesis. . 2013 Oct 15; 305(8):H1189-200. PMID: 23934853.
    Citations: 14     Translation:AnimalsCells
  41. Sayadi O, Merchant FM, Puppala D, Mela T, Singh JP, Heist EK, Owen C, Armoundas AA. A novel method for determining the phase of T-wave alternans: diagnostic and therapeutic implications. Circ Arrhythm Electrophysiol. 2013 Aug; 6(4):818-26. PMID: 23884196.
    Citations: 3     Fields:    Translation:Animals
  42. Lee K, Lv W, Ter-Ovanesyan E, Barley ME, Voysey GE, Galea AM, Hirschman GB, Leroy K, Marini RP, Barrett C, Armoundas AA, Cohen RJ. Cardiac ablation catheter guidance by means of a single equivalent moving dipole inverse algorithm. Pacing Clin Electrophysiol. 2013 Jul; 36(7):811-22. PMID: 23448231.
    Citations: 3     Fields:    Translation:Animals
  43. Armoundas AA, Weiss EH, Sayadi O, Laferriere S, Sajja N, Mela T, Singh JP, Barrett CD, Kevin Heist E, Merchant FM. A novel pacing method to suppress repolarization alternans in vivo: implications for arrhythmia prevention. Heart Rhythm. 2013 Apr; 10(4):564-72. PMID: 23274372.
    Citations: 7     Fields:    Translation:Animals
  44. Merchant FM, Ikeda T, Pedretti RF, Salerno-Uriarte JA, Chow T, Chan PS, Bartone C, Hohnloser SH, Cohen RJ, Armoundas AA. Clinical utility of microvolt T-wave alternans testing in identifying patients at high or low risk of sudden cardiac death. Heart Rhythm. 2012 Aug; 9(8):1256-64.e2. PMID: 22406384.
    Citations: 20     Fields:    Translation:Humans
  45. Merchant FM, Armoundas AA. Role of substrate and triggers in the genesis of cardiac alternans, from the myocyte to the whole heart: implications for therapy. Circulation. 2012 Jan 24; 125(3):539-49. PMID: 22271847.
    Citations: 24     Fields:    Translation:HumansCells
  46. Iyer V, Heller V, Armoundas AA. Altered spatial calcium regulation enhances electrical heterogeneity in the failing canine left ventricle: implications for electrical instability. J Appl Physiol (1985). 2012 Mar; 112(6):944-55. PMID: 22194323.
    Citations: 7     Fields:    Translation:AnimalsCells
  47. Armoundas AA, Mela T, Merchant FM. On the estimation of T-wave alternans using the spectral fast fourier transform method. Heart Rhythm. 2012 Mar; 9(3):449-56. PMID: 22001706.
    Citations: 3     Fields:    Translation:Humans
  48. Weiss EH, Merchant FM, d'Avila A, Foley L, Reddy VY, Singh JP, Mela T, Ruskin JN, Armoundas AA. A novel lead configuration for optimal spatio-temporal detection of intracardiac repolarization alternans. Circ Arrhythm Electrophysiol. 2011 Jun; 4(3):407-17. PMID: 21430127.
    Citations: 13     Fields:    Translation:Animals
  49. Guo LS, Zhou X, Li YH, Cai J, Wei DM, Shi L, Yang G, Armoundas AA, Yang XC. Alcohol ablation at the posterior papillary muscle prevents ventricular fibrillation in swine without affecting mitral valve function. Europace. 2010 Dec; 12(12):1781-6. PMID: 20858694.
    Citations: 1     Fields:    Translation:Animals
  50. Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Wavelet analysis reveals heterogeneous time-dependent oscillations of individual mitochondria. . 2010 Nov; 299(5):H1736-40. PMID: 20833956.
    Citations: 11     Translation:AnimalsCells
  51. Kurz FT, Aon MA, O'Rourke B, Armoundas AA. Spatio-temporal oscillations of individual mitochondria in cardiac myocytes reveal modulation of synchronized mitochondrial clusters. Proc Natl Acad Sci U S A. 2010 Aug 10; 107(32):14315-20. PMID: 20656937.
    Citations: 35     Fields:    Translation:AnimalsCells
  52. Katritsis D, Merchant FM, Mela T, Singh JP, Heist EK, Armoundas AA. Catheter ablation of atrial fibrillation the search for substrate-driven end points. J Am Coll Cardiol. 2010 May 25; 55(21):2293-8. PMID: 20488298.
    Citations: 8     Fields:    Translation:Humans
  53. Armoundas AA. Discordant calcium transient and action potential alternans in a canine left-ventricular myocyte. IEEE Trans Biomed Eng. 2009 Sep; 56(9):2340-4. PMID: 19497812.
    Citations: 3     Fields:    Translation:AnimalsCells
  54. Fukuoka Y, Oostendorp TF, Armoundas AA. Method for guiding the ablation catheter to the ablation site: a simulation and experimental study. Med Biol Eng Comput. 2009 Mar; 47(3):267-78. PMID: 19194733.
    Citations: 5     Fields:    Translation:Humans
  55. Barley ME, Choppy KJ, Galea AM, Armoundas AA, Rosbury TS, Hirschman GB, Cohen RJ. Validation of a novel catheter guiding method for the ablative therapy of ventricular tachycardia in a phantom model. IEEE Trans Biomed Eng. 2009 Mar; 56(3):907-10. PMID: 19272901.
    Citations: 3     Fields:    
  56. Barley ME, Armoundas AA, Cohen RJ. A method for guiding ablation catheters to arrhythmogenic sites using body surface electrocardiographic signals. IEEE Trans Biomed Eng. 2009 Mar; 56(3):810-9. PMID: 19272900.
    Citations: 3     Fields:    Translation:Humans
  57. Armoundas AA. Mechanism of abnormal sarcoplasmic reticulum calcium release in canine left-ventricular myocytes results in cellular alternans. IEEE Trans Biomed Eng. 2009 Feb; 56(2):220-8. PMID: 19272939.
    Citations: 5     Fields:    Translation:AnimalsCells
  58. Deschênes I, Armoundas AA, Jones SP, Tomaselli GF. Post-transcriptional gene silencing of KChIP2 and Navbeta1 in neonatal rat cardiac myocytes reveals a functional association between Na and Ito currents. J Mol Cell Cardiol. 2008 Sep; 45(3):336-46. PMID: 18565539.
    Citations: 45     Fields:    Translation:HumansAnimalsCells
  59. Iyer V, Hajjar RJ, Armoundas AA. Mechanisms of abnormal calcium homeostasis in mutations responsible for catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2007 Feb 02; 100(2):e22-31. PMID: 17234962.
    Citations: 13     Fields:    Translation:Humans
  60. Fukuoka Y, Oostendorp TF, Sherman DA, Armoundas AA. Applicability of the single equivalent moving dipole model in an infinite homogeneous medium to identify cardiac electrical sources: a computer simulation study in a realistic anatomic geometry torso model. IEEE Trans Biomed Eng. 2006 Dec; 53(12 Pt 1):2436-44. PMID: 17153200.
    Citations: 7     Fields:    Translation:Humans
  61. Armoundas AA, Rose J, Aggarwal R, Stuyvers BD, O'rourke B, Kass DA, Marbán E, Shorofsky SR, Tomaselli GF, William Balke C. Cellular and molecular determinants of altered Ca2+ handling in the failing rabbit heart: primary defects in SR Ca2+ uptake and release mechanisms. . 2007 Mar; 292(3):H1607-18. PMID: 17122195.
    Citations: 27     Translation:AnimalsCells
  62. Iyer V, Armoundas AA. Unraveling the mechanisms of catecholaminergic polymorphic ventricular tachycardia. Conf Proc IEEE Eng Med Biol Soc. 2006; Suppl:6761-4. PMID: 17959506.
    Citations: 2     Fields:    Translation:HumansCells
  63. Armoundas AA, Hohnloser SH, Ikeda T, Cohen RJ. Can microvolt T-wave alternans testing reduce unnecessary defibrillator implantation? Nat Clin Pract Cardiovasc Med. 2005 Oct; 2(10):522-8. PMID: 16186850.
    Citations: 15     Fields:    Translation:Humans
  64. Akar FG, Wu RC, Juang GJ, Tian Y, Burysek M, Disilvestre D, Xiong W, Armoundas AA, Tomaselli GF. Molecular mechanisms underlying K+ current downregulation in canine tachycardia-induced heart failure. . 2005 Jun; 288(6):H2887-96. PMID: 15681701.
    Citations: 24     Translation:AnimalsCells
  65. Rose J, Armoundas AA, Tian Y, DiSilvestre D, Burysek M, Halperin V, O'Rourke B, Kass DA, Marbán E, Tomaselli GF. Molecular correlates of altered expression of potassium currents in failing rabbit myocardium. . 2005 May; 288(5):H2077-87. PMID: 15637125.
    Citations: 43     Translation:Animals
  66. Armoundas AA, Albert CM, Cohen RJ, Mela T. Utility of implantable cardioverter defibrillator electrograms to estimate repolarization alternans preceding a tachyarrhythmic event. J Cardiovasc Electrophysiol. 2004 May; 15(5):594-7. PMID: 15149432.
    Citations: 8     Fields:    Translation:Humans
  67. Armoundas AA, Feldman AB, Mukkamala R, He B, Mullen TJ, Belk PA, Lee YZ, Cohen RJ. Statistical accuracy of a moving equivalent dipole method to identify sites of origin of cardiac electrical activation. IEEE Trans Biomed Eng. 2003 Dec; 50(12):1360-70. PMID: 14656065.
    Citations: 8     Fields:    Translation:Animals
  68. Akar FG, Wu RC, Deschenes I, Armoundas AA, Piacentino V, Houser SR, Tomaselli GF. Phenotypic differences in transient outward K+ current of human and canine ventricular myocytes: insights into molecular composition of ventricular Ito. . 2004 Feb; 286(2):H602-9. PMID: 14527940.
    Citations: 34     Translation:HumansAnimalsCells
  69. Armoundas AA, Hobai IA, Tomaselli GF, Winslow RL, O'Rourke B. Role of sodium-calcium exchanger in modulating the action potential of ventricular myocytes from normal and failing hearts. Circ Res. 2003 Jul 11; 93(1):46-53. PMID: 12805237.
    Citations: 62     Fields:    Translation:AnimalsCells
  70. Armoundas AA, Feldman AB, Mukkamala R, Cohen RJ. A single equivalent moving dipole model: an efficient approach for localizing sites of origin of ventricular electrical activation. Ann Biomed Eng. 2003 May; 31(5):564-76. PMID: 12757200.
    Citations: 19     Fields:    Translation:Humans
  71. Armoundas AA, Tomaselli GF, Esperer HD. Pathophysiological basis and clinical application of T-wave alternans. J Am Coll Cardiol. 2002 Jul 17; 40(2):207-17. PMID: 12106921.
    Citations: 24     Fields:    Translation:Humans
  72. Mazhari R, Nuss HB, Armoundas AA, Winslow RL, Marbán E. Ectopic expression of KCNE3 accelerates cardiac repolarization and abbreviates the QT interval. J Clin Invest. 2002 Apr; 109(8):1083-90. PMID: 11956246.
    Citations: 15     Fields:    Translation:HumansAnimalsCells
  73. Armoundas AA, Ju K, Iyengar N, Kanters JK, Saul PJ, Cohen RJ, Chon KH. A stochastic nonlinear autoregressive algorithm reflects nonlinear dynamics of heart-rate fluctuations. Ann Biomed Eng. 2002 Feb; 30(2):192-201. PMID: 11962771.
    Citations: 5     Fields:    Translation:Humans
  74. Armoundas AA, Wu R, Juang G, Marbán E, Tomaselli GF. Electrical and structural remodeling of the failing ventricle. Pharmacol Ther. 2001 Nov-Dec; 92(2-3):213-30. PMID: 11916538.
    Citations: 29     Fields:    Translation:HumansCells
  75. Armoundas AA, Feldman AB, Sherman DA, Cohen RJ. Applicability of the single equivalent point dipole model to represent a spatially distributed bio-electrical source. Med Biol Eng Comput. 2001 Sep; 39(5):562-70. PMID: 11712653.
    Citations: 5     Fields:    
  76. Armoundas AA, Nanke T, Cohen RJ. Images in cardiovascular medicine. T-wave alternans preceding torsade de pointes ventricular tachycardia. Circulation. 2000 May 30; 101(21):2550. PMID: 10831532.
    Citations: 6     Fields:    Translation:Humans
  77. Fukuoka Y, Armoundas AA, Oostendorp TF, Cohen RJ. Accuracy of a single equivalent moving dipole model in a realistic anatomic geometry torso model. Comput Cardiol. 2000; 27:439-42. PMID: 14632014.
    Citations: 1     Translation:Humans
  78. Chon KH, Hoyer D, Armoundas AA, Holstein-Rathlou NH, Marsh DJ. Robust nonlinear autoregressive moving average model parameter estimation using stochastic recurrent artificial neural networks. Ann Biomed Eng. 1999 Jul-Aug; 27(4):538-47. PMID: 10468238.
    Citations: 1     Fields:    Translation:Animals
  79. Armoundas AA, Osaka M, Mela T, Rosenbaum DS, Ruskin JN, Garan H, Cohen RJ. T-wave alternans and dispersion of the QT interval as risk stratification markers in patients susceptible to sustained ventricular arrhythmias. Am J Cardiol. 1998 Nov 01; 82(9):1127-9, A9. PMID: 9817496.
    Citations: 6     Fields:    Translation:Humans
  80. Armoundas AA, Rosenbaum DS, Ruskin JN, Garan H, Cohen RJ. Prognostic significance of electrical alternans versus signal averaged electrocardiography in predicting the outcome of electrophysiological testing and arrhythmia-free survival. Heart. 1998 Sep; 80(3):251-6. PMID: 9875084.
    Citations: 6     Fields:    Translation:Humans
  81. Chon KH, Mukkamala R, Toska K, Mullen TJ, Armoundas AA, Cohen RJ. Linear and nonlinear system identification of autonomic heart-rate modulation. IEEE Eng Med Biol Mag. 1997 Sep-Oct; 16(5):96-105. PMID: 9313086.
    Citations: 4     Fields:    Translation:Humans
  82. Armoundas AA, Cohen RJ. Clinical utility of T-wave alternans. Card Electrophysiol Rev. 1997; 1(3):390-4. PMID: 11541510.
    Citations: 4     Fields:    Translation:HumansAnimals
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.