Harvard Catalyst Profiles

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Thomas McCoy Roberts, Ph.D.

Concepts

This page shows the publications Thomas Roberts has written about Phosphorylation.
Connection Strength

0.681
  1. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. J Virol. 2014 Oct; 88(20):12055-64.
    View in: PubMed
    Score: 0.061
  2. Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Mol Biol Cell. 2009 Jul; 20(14):3200-8.
    View in: PubMed
    Score: 0.042
  3. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 2009 Feb 20; 384(2):304-16.
    View in: PubMed
    Score: 0.041
  4. Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motil Cytoskeleton. 2007 Apr; 64(4):235-47.
    View in: PubMed
    Score: 0.036
  5. A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell. 2007 May; 18(5):1816-25.
    View in: PubMed
    Score: 0.036
  6. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem. 2006 Aug 11; 281(32):23003-12.
    View in: PubMed
    Score: 0.034
  7. Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science. 2003 Nov 21; 302(5649):1405-7.
    View in: PubMed
    Score: 0.029
  8. A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. J Cell Sci. 2003 Jul 01; 116(Pt 13):2655-63.
    View in: PubMed
    Score: 0.028
  9. The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene. 2000 Aug 17; 19(35):3961-70.
    View in: PubMed
    Score: 0.023
  10. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2020 01; 39(1):50-63.
    View in: PubMed
    Score: 0.021
  11. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Mol Cell Biol. 1999 Jul; 19(7):4819-24.
    View in: PubMed
    Score: 0.021
  12. Cell density modulates protein-tyrosine phosphorylation. J Biol Chem. 1998 Feb 06; 273(6):3408-14.
    View in: PubMed
    Score: 0.019
  13. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 08 24; 548(7668):471-475.
    View in: PubMed
    Score: 0.019
  14. Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol. 2016 08 15; 90(16):7032-7045.
    View in: PubMed
    Score: 0.017
  15. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 07; 22(7):723-6.
    View in: PubMed
    Score: 0.017
  16. Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene. 1995 Aug 03; 11(3):427-38.
    View in: PubMed
    Score: 0.016
  17. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. J Biol Chem. 1995 May 26; 270(21):12331-4.
    View in: PubMed
    Score: 0.016
  18. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science. 1994 Oct 07; 266(5182):126-9.
    View in: PubMed
    Score: 0.015
  19. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr Biol. 2014 Oct 06; 24(19):2274-80.
    View in: PubMed
    Score: 0.015
  20. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):442-6.
    View in: PubMed
    Score: 0.014
  21. K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One. 2012; 7(8):e44146.
    View in: PubMed
    Score: 0.013
  22. Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck. Int Immunol. 1991 Jul; 3(7):673-82.
    View in: PubMed
    Score: 0.012
  23. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol. 1990 Jan; 64(1):61-8.
    View in: PubMed
    Score: 0.011
  24. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):8855-9.
    View in: PubMed
    Score: 0.010
  25. Cellular proteins that associate with the middle and small T antigens of polyomavirus. J Virol. 1988 Nov; 62(11):3934-40.
    View in: PubMed
    Score: 0.010
  26. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 07; 454(7205):776-9.
    View in: PubMed
    Score: 0.010
  27. Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol. 1988 Jan; 8(1):176-85.
    View in: PubMed
    Score: 0.010
  28. Tyrosine phosphorylation in signal transduction. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:161-71.
    View in: PubMed
    Score: 0.010
  29. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19011-6.
    View in: PubMed
    Score: 0.009
  30. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76.
    View in: PubMed
    Score: 0.007
  31. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 2003 May; 3(5):483-95.
    View in: PubMed
    Score: 0.007
  32. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. J Biol Chem. 1999 Nov 05; 274(45):32274-8.
    View in: PubMed
    Score: 0.005
  33. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90.
    View in: PubMed
    Score: 0.005
  34. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997 Mar; 17(3):1562-71.
    View in: PubMed
    Score: 0.005
  35. Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. Blood. 1997 Jan 01; 89(1):55-64.
    View in: PubMed
    Score: 0.004
  36. Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. Structure. 1996 Sep 15; 4(9):1105-14.
    View in: PubMed
    Score: 0.004
  37. Tyrosine kinase triggering in thymocytes undergoing positive selection. Eur J Immunol. 1992 Sep; 22(9):2289-94.
    View in: PubMed
    Score: 0.003
  38. Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2922-6.
    View in: PubMed
    Score: 0.003
  39. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 1992 Mar 20; 68(6):1041-50.
    View in: PubMed
    Score: 0.003
  40. Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992 Mar; 3(3):157-64.
    View in: PubMed
    Score: 0.003
  41. Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6254-8.
    View in: PubMed
    Score: 0.003
  42. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. J Virol. 1991 Jul; 65(7):3681-92.
    View in: PubMed
    Score: 0.003
  43. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. Blood. 1991 Jan 15; 77(2):243-8.
    View in: PubMed
    Score: 0.003
  44. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. J Virol. 1990 Sep; 64(9):4454-61.
    View in: PubMed
    Score: 0.003
  45. Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. J Immunol. 1990 Jan 15; 144(2):647-52.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.