Harvard Catalyst Profiles

Contact, publication, and social network information about Harvard faculty and fellows.

Thomas McCoy Roberts, Ph.D.

Concepts

This page shows the publications Thomas Roberts has written about Mice.
Connection Strength

0.497
  1. The role of the PIK3CA gene in the development and aging of the brain. Sci Rep. 2021 01 11; 11(1):291.
    View in: PubMed
    Score: 0.034
  2. Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochem Biophys Res Commun. 1999 Aug 27; 262(2):438-42.
    View in: PubMed
    Score: 0.031
  3. Rac1-mediated membrane raft localization of PI3K/p110ß is required for its activation by GPCRs or PTEN loss. Elife. 2016 10 04; 5.
    View in: PubMed
    Score: 0.025
  4. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. J Virol. 2014 Oct; 88(20):12055-64.
    View in: PubMed
    Score: 0.022
  5. Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene. 2015 May 07; 34(19):2483-92.
    View in: PubMed
    Score: 0.021
  6. The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. J Virol. 2014 Sep; 88(18):10673-9.
    View in: PubMed
    Score: 0.021
  7. Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 2013 Jan; 3(1):44-51.
    View in: PubMed
    Score: 0.019
  8. Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol. 2011 Jun; 85(11):5581-92.
    View in: PubMed
    Score: 0.017
  9. A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11002-7.
    View in: PubMed
    Score: 0.016
  10. PI3 kinases in cancer: from oncogene artifact to leading cancer target. Sci STKE. 2006 Dec 12; 2006(365):pe52.
    View in: PubMed
    Score: 0.013
  11. The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16296-300.
    View in: PubMed
    Score: 0.013
  12. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem. 2006 Aug 11; 281(32):23003-12.
    View in: PubMed
    Score: 0.012
  13. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18443-8.
    View in: PubMed
    Score: 0.012
  14. A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9434-9.
    View in: PubMed
    Score: 0.010
  15. DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem. 2002 Mar 08; 277(10):7962-9.
    View in: PubMed
    Score: 0.009
  16. Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Rep. 2020 09 29; 32(13):108196.
    View in: PubMed
    Score: 0.008
  17. Constitutive cellular expression of PI 3-kinase is distinct from transient expression. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):822-9.
    View in: PubMed
    Score: 0.008
  18. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16.
    View in: PubMed
    Score: 0.008
  19. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Mol Cell Biol. 1999 Jul; 19(7):4819-24.
    View in: PubMed
    Score: 0.008
  20. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Mol Cell Biol. 1999 Mar; 19(3):2330-7.
    View in: PubMed
    Score: 0.007
  21. Cell density modulates protein-tyrosine phosphorylation. J Biol Chem. 1998 Feb 06; 273(6):3408-14.
    View in: PubMed
    Score: 0.007
  22. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 08 24; 548(7668):471-475.
    View in: PubMed
    Score: 0.007
  23. PI3K-p110a mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85a. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):7095-7100.
    View in: PubMed
    Score: 0.007
  24. Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol. 2016 08 15; 90(16):7032-7045.
    View in: PubMed
    Score: 0.006
  25. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30.
    View in: PubMed
    Score: 0.006
  26. A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors. Int J Cancer. 1996 Jun 11; 66(6):753-9.
    View in: PubMed
    Score: 0.006
  27. PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. Cell Rep. 2016 06 21; 15(12):2692-704.
    View in: PubMed
    Score: 0.006
  28. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 07; 22(7):723-6.
    View in: PubMed
    Score: 0.006
  29. Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. Oncotarget. 2016 Mar 15; 7(11):13153-66.
    View in: PubMed
    Score: 0.006
  30. A PI3K p110ß-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis. Nat Commun. 2015 Oct 07; 6:8501.
    View in: PubMed
    Score: 0.006
  31. Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene. 1995 Aug 03; 11(3):427-38.
    View in: PubMed
    Score: 0.006
  32. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. J Biol Chem. 1995 May 26; 270(21):12331-4.
    View in: PubMed
    Score: 0.006
  33. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science. 1994 Oct 07; 266(5182):126-9.
    View in: PubMed
    Score: 0.005
  34. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science. 1994 Jul 22; 265(5171):535-7.
    View in: PubMed
    Score: 0.005
  35. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 2014 Jul 03; 158(1):171-84.
    View in: PubMed
    Score: 0.005
  36. PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6395-400.
    View in: PubMed
    Score: 0.005
  37. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a. J Clin Invest. 2014 Apr; 124(4):1794-809.
    View in: PubMed
    Score: 0.005
  38. Polyomavirus middle T-antigen NPTY mutants. J Virol. 1992 Oct; 66(10):5770-6.
    View in: PubMed
    Score: 0.005
  39. K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One. 2012; 7(8):e44146.
    View in: PubMed
    Score: 0.005
  40. The p110a and p110ß isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev. 2012 Jul 15; 26(14):1573-86.
    View in: PubMed
    Score: 0.005
  41. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol. 2011 Oct; 85(20):10649-58.
    View in: PubMed
    Score: 0.004
  42. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell. 1990 Jan 12; 60(1):167-76.
    View in: PubMed
    Score: 0.004
  43. The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins. J Virol. 1989 Nov; 63(11):4533-9.
    View in: PubMed
    Score: 0.004
  44. Signal transduction from membrane to cytoplasm: growth factors and membrane-bound oncogene products increase Raf-1 phosphorylation and associated protein kinase activity. Proc Natl Acad Sci U S A. 1988 Dec; 85(23):8855-9.
    View in: PubMed
    Score: 0.004
  45. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro. J Virol. 1988 Sep; 62(9):3407-14.
    View in: PubMed
    Score: 0.004
  46. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 07; 454(7205):776-9.
    View in: PubMed
    Score: 0.004
  47. Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol. 1988 Jan; 8(1):176-85.
    View in: PubMed
    Score: 0.003
  48. Tyrosine phosphorylation in signal transduction. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:161-71.
    View in: PubMed
    Score: 0.003
  49. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19011-6.
    View in: PubMed
    Score: 0.003
  50. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11; 449(7163):689-94.
    View in: PubMed
    Score: 0.003
  51. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul; 81(13):7069-76.
    View in: PubMed
    Score: 0.003
  52. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23; 128(6):1077-88.
    View in: PubMed
    Score: 0.003
  53. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004 Dec 15; 64(24):8867-75.
    View in: PubMed
    Score: 0.003
  54. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):947-52.
    View in: PubMed
    Score: 0.003
  55. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3336-41.
    View in: PubMed
    Score: 0.002
  56. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999 Oct 22; 274(43):31062-7.
    View in: PubMed
    Score: 0.002
  57. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90.
    View in: PubMed
    Score: 0.002
  58. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997 Mar; 17(3):1562-71.
    View in: PubMed
    Score: 0.002
  59. Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. Blood. 1997 Jan 01; 89(1):55-64.
    View in: PubMed
    Score: 0.002
  60. Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes. J Biol Chem. 1996 Sep 20; 271(38):23452-7.
    View in: PubMed
    Score: 0.002
  61. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J Virol. 1995 Jun; 69(6):3721-8.
    View in: PubMed
    Score: 0.001
  62. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6344-8.
    View in: PubMed
    Score: 0.001
  63. Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection. J Immunol. 1992 Nov 15; 149(10):3142-9.
    View in: PubMed
    Score: 0.001
  64. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10435-9.
    View in: PubMed
    Score: 0.001
  65. Tyrosine kinase triggering in thymocytes undergoing positive selection. Eur J Immunol. 1992 Sep; 22(9):2289-94.
    View in: PubMed
    Score: 0.001
  66. Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992 Mar; 3(3):157-64.
    View in: PubMed
    Score: 0.001
  67. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. J Virol. 1990 Sep; 64(9):4454-61.
    View in: PubMed
    Score: 0.001
  68. Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem. 1990 Jun 25; 265(18):10746-51.
    View in: PubMed
    Score: 0.001
  69. Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts. Science. 1988 Feb 26; 239(4843):1024-6.
    View in: PubMed
    Score: 0.001
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.