Harvard Catalyst Profiles

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Thomas McCoy Roberts, Ph.D.

Concepts

This page shows the publications Thomas Roberts has written about Cell Transformation, Neoplastic.
  1. The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16296-300.
    View in: PubMed
    Score: 0.153
  2. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18443-8.
    View in: PubMed
    Score: 0.144
  3. The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene. 2000 Aug 17; 19(35):3961-70.
    View in: PubMed
    Score: 0.100
  4. Constitutive cellular expression of PI 3-kinase is distinct from transient expression. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):822-9.
    View in: PubMed
    Score: 0.099
  5. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. J Biol Chem. 1995 May 26; 270(21):12331-4.
    View in: PubMed
    Score: 0.069
  6. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science. 1994 Jul 22; 265(5171):535-7.
    View in: PubMed
    Score: 0.065
  7. The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. J Virol. 2014 Sep; 88(18):10673-9.
    View in: PubMed
    Score: 0.065
  8. The p110a and p110ß isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev. 2012 Jul 15; 26(14):1573-86.
    View in: PubMed
    Score: 0.057
  9. Mechanisms of transformation by polyoma virus middle T antigen. Biochim Biophys Acta. 1989 Feb; 948(3):345-64.
    View in: PubMed
    Score: 0.045
  10. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro. J Virol. 1988 Sep; 62(9):3407-14.
    View in: PubMed
    Score: 0.044
  11. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 07; 454(7205):776-9.
    View in: PubMed
    Score: 0.043
  12. Tyrosine phosphorylations in vivo associated with v-fms transformation. Mol Cell Biol. 1988 Jan; 8(1):176-85.
    View in: PubMed
    Score: 0.042
  13. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul; 81(13):7069-76.
    View in: PubMed
    Score: 0.040
  14. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004 Dec 15; 64(24):8867-75.
    View in: PubMed
    Score: 0.034
  15. The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10296-301.
    View in: PubMed
    Score: 0.033
  16. Functional genetics and experimental models of human cancer. Trends Mol Med. 2004 Jul; 10(7):344-50.
    View in: PubMed
    Score: 0.033
  17. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 2003 May; 3(5):483-95.
    View in: PubMed
    Score: 0.030
  18. PI3K-p110a mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85a. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):7095-7100.
    View in: PubMed
    Score: 0.020
  19. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):123-131.
    View in: PubMed
    Score: 0.020
  20. Voltage-sensitive calcium channels in normal and transformed 3T3 fibroblasts. Science. 1988 Feb 26; 239(4843):1024-6.
    View in: PubMed
    Score: 0.010
  21. Tyrosine phosphorylation in signal transduction. Cold Spring Harb Symp Quant Biol. 1988; 53 Pt 1:161-71.
    View in: PubMed
    Score: 0.010
  22. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007 Jun 15; 129(6):1065-79.
    View in: PubMed
    Score: 0.010
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.