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Thomas McCoy Roberts, Ph.D.

Concepts

This page shows the publications Thomas Roberts has written about Antigens, Polyomavirus Transforming.
  1. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. J Virol. 2014 Oct; 88(20):12055-64.
    View in: PubMed
    Score: 0.536
  2. Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol. 2011 Jun; 85(11):5581-92.
    View in: PubMed
    Score: 0.423
  3. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 2009 Feb 20; 384(2):304-16.
    View in: PubMed
    Score: 0.361
  4. Induction of p53-independent apoptosis by simian virus 40 small t antigen. J Virol. 2001 Oct; 75(19):9142-55.
    View in: PubMed
    Score: 0.220
  5. pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol. 2000 Jan; 74(2):864-74.
    View in: PubMed
    Score: 0.195
  6. Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol. 2016 08 15; 90(16):7032-7045.
    View in: PubMed
    Score: 0.154
  7. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. J Biol Chem. 1995 May 26; 270(21):12331-4.
    View in: PubMed
    Score: 0.142
  8. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol. 2015 Mar; 89(5):2857-65.
    View in: PubMed
    Score: 0.138
  9. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science. 1994 Jul 22; 265(5171):535-7.
    View in: PubMed
    Score: 0.134
  10. The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. J Virol. 2014 Sep; 88(18):10673-9.
    View in: PubMed
    Score: 0.133
  11. Polyomavirus middle T-antigen NPTY mutants. J Virol. 1992 Oct; 66(10):5770-6.
    View in: PubMed
    Score: 0.118
  12. Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J Virol. 1992 Mar; 66(3):1702-8.
    View in: PubMed
    Score: 0.113
  13. Polyoma small and middle T antigens and SV40 small t antigen form stable complexes with protein phosphatase 2A. Cell. 1990 Jan 12; 60(1):167-76.
    View in: PubMed
    Score: 0.098
  14. Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol. 1990 Jan; 64(1):61-8.
    View in: PubMed
    Score: 0.097
  15. The cellular proteins which can associate specifically with polyomavirus middle T antigen in human 293 cells include the major human 70-kilodalton heat shock proteins. J Virol. 1989 Nov; 63(11):4533-9.
    View in: PubMed
    Score: 0.096
  16. Cellular proteins that associate with the middle and small T antigens of polyomavirus. J Virol. 1988 Nov; 62(11):3934-40.
    View in: PubMed
    Score: 0.090
  17. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009 Jan; 83(1):117-27.
    View in: PubMed
    Score: 0.090
  18. Recombinant retroviruses that transduce middle T antigen cDNAs derived from polyomavirus mutants: separation of focus formation and soft-agar growth in transformation assays and correlations with kinase activities in vitro. J Virol. 1988 Sep; 62(9):3407-14.
    View in: PubMed
    Score: 0.089
  19. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul; 81(13):7069-76.
    View in: PubMed
    Score: 0.081
  20. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18443-8.
    View in: PubMed
    Score: 0.073
  21. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):947-52.
    View in: PubMed
    Score: 0.064
  22. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90.
    View in: PubMed
    Score: 0.041
  23. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 01; 11(9):1098-110.
    View in: PubMed
    Score: 0.040
  24. A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors. Int J Cancer. 1996 Jun 11; 66(6):753-9.
    View in: PubMed
    Score: 0.038
  25. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J Virol. 1995 Jun; 69(6):3721-8.
    View in: PubMed
    Score: 0.035
  26. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6344-8.
    View in: PubMed
    Score: 0.033
  27. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. J Virol. 1990 Sep; 64(9):4454-61.
    View in: PubMed
    Score: 0.025
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Funded by the NIH National Center for Advancing Translational Sciences through its Clinical and Translational Science Awards Program, grant number UL1TR002541.