Harvard Catalyst Profiles

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Thomas McCoy Roberts, Ph.D.



The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. R35CA231945 (ROBERTS, THOMAS M) Sep 1, 2019 - Aug 31, 2026
    Maximizing the Effectiveness of PI3K Inhibitors in the Treatment of Pten null Cancers
    Role: Principal Investigator
  2. T32CA236754 (DANIAL, NIKA N) Apr 1, 2019 - Mar 31, 2024
    Cancer Chemical Biology and Metabolism Training Program
    Role: Principal Investigator
  3. R01CA233810 (ROBERTS, THOMAS M) Dec 1, 2018 - Nov 30, 2019
    Molecular mechanisms and therapeutic targeting of PI3K-p110beta/PTEN signaling in breast cancer and cancer immunity
    Role: Principal Investigator
  4. R01CA187918 (ROBERTS, THOMAS M) Apr 1, 2015 - Mar 31, 2020
    Targeting the p110beta isoform of PI3 kinase in prostate cancer
    Role: Co-Principal Investigator
  5. P50CA165962 (BATCHELOR, TRACY T) Sep 19, 2013 - Aug 31, 2024
    SPORE: Targeted Therapies for Glioma
    Role: Co-Principal Investigator

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
  1. Manokaran C, Roberts TM, Wang Y. More than one route to render tumors resistant to cGAS/STING activation. Trends Pharmacol Sci. 2022 Nov 19. PMID: 36414433.
    Citations:    Fields:    
  2. Wang Q, Bergholz JS, Ding L, Lin Z, Kabraji SK, Hughes ME, He X, Xie S, Jiang T, Wang W, Zoeller JJ, Kim HJ, Roberts TM, Konstantinopoulos PA, Matulonis UA, Dillon DA, Winer EP, Lin NU, Zhao JJ. STING agonism reprograms tumor-associated macrophages and overcomes resistance to PARP inhibition in BRCA1-deficient models of breast cancer. Nat Commun. 2022 05 31; 13(1):3022. PMID: 35641483; PMCID: PMC9156717.
    Citations:    Fields:    Translation:HumansAnimalsCells
  3. Gao X, Wang Y, Ribeiro CF, Manokaran C, Chang H, Von T, Rodrigues S, Cizmecioglu O, Jia S, Korpal M, Korn JM, Wang Z, Schmit F, Jiang L, Pagliarini R, Yang Y, Sethi I, Signoretti S, Yuan GC, Loda M, Zhao JJ, Roberts TM. Blocking PI3K p110ß Attenuates Development of PTEN-Deficient Castration-Resistant Prostate Cancer. Mol Cancer Res. 2022 05 04; 20(5):673-685. PMID: 35105671; PMCID: PMC9081176.
    Citations: 1     Fields:    Translation:HumansAnimals
  4. Wang Y, Manokaran C, Wu S, Roberts TM. The Mediator captures CDK7, an attractive transcriptional target in cancer. Cancer Cell. 2021 09 13; 39(9):1184-1186. PMID: 34416166.
    Citations:    Fields:    Translation:HumansAnimalsCells
  5. Li J, Cai Z, Bomgarden RD, Pike I, Kuhn K, Rogers JC, Roberts TM, Gygi SP, Paulo JA. TMTpro-18plex: The Expanded and Complete Set of TMTpro Reagents for Sample Multiplexing. J Proteome Res. 2021 05 07; 20(5):2964-2972. PMID: 33900084; PMCID: PMC8210943.
    Citations: 26     Fields:    Translation:Cells
  6. Xie S, Ni J, Guo H, Luu V, Wang Y, Zhao JJ, Roberts TM. The role of the PIK3CA gene in the development and aging of the brain. Sci Rep. 2021 01 11; 11(1):291. PMID: 33431926.
    Citations: 1     Fields:    Translation:Animals
  7. Xie S, Ni J, McFaline-Figueroa JR, Wang Y, Bronson RT, Ligon KL, Wen PY, Roberts TM, Zhao JJ. Divergent Roles of PI3K Isoforms in PTEN-Deficient Glioblastomas. Cell Rep. 2020 09 29; 32(13):108196. PMID: 32997991.
    Citations: 5     Fields:    Translation:HumansAnimals
  8. Spangle JM, Von T, Pavlick DC, Khotimsky A, Zhao JJ, Roberts TM. PIK3CA C-terminal frameshift mutations are novel oncogenic events that sensitize tumors to PI3K-a inhibition. Proc Natl Acad Sci U S A. 2020 09 29; 117(39):24427-24433. PMID: 32929011.
    Citations: 4     Fields:    Translation:HumansCells
  9. Sun B, Mason S, Wilson RC, Hazard SE, Wang Y, Fang R, Wang Q, Yeh ES, Yang M, Roberts TM, Zhao JJ, Wang Q. Inhibition of the transcriptional kinase CDK7 overcomes therapeutic resistance in HER2-positive breast cancers. Oncogene. 2020 01; 39(1):50-63. PMID: 31462705.
    Citations: 15     Fields:    Translation:HumansCells
  10. Hemmati S, Sinclair T, Tong M, Bartholdy B, Okabe RO, Ames K, Ostrodka L, Haque T, Kaur I, Mills TS, Agarwal A, Pietras EM, Zhao JJ, Roberts TM, Gritsman K. PI3 kinase alpha and delta promote hematopoietic stem cell activation. JCI Insight. 2019 05 23; 5. PMID: 31120863.
    Citations: 9     Fields:    Translation:AnimalsCells
  11. Wen PY, Touat M, Alexander BM, Mellinghoff IK, Ramkissoon S, McCluskey CS, Pelton K, Haidar S, Basu SS, Gaffey SC, Brown LE, Martinez-Ledesma JE, Wu S, Kim J, Wei W, Park MA, Huse JT, Kuhn JG, Rinne ML, Colman H, Agar NYR, Omuro AM, DeAngelis LM, Gilbert MR, de Groot JF, Cloughesy TF, Chi AS, Roberts TM, Zhao JJ, Lee EQ, Nayak L, Heath JR, Horky LL, Batchelor TT, Beroukhim R, Chang SM, Ligon AH, Dunn IF, Koul D, Young GS, Prados MD, Reardon DA, Yung WKA, Ligon KL. Buparlisib in Patients With Recurrent Glioblastoma Harboring Phosphatidylinositol 3-Kinase Pathway Activation: An Open-Label, Multicenter, Multi-Arm, Phase II Trial. J Clin Oncol. 2019 03 20; 37(9):741-750. PMID: 30715997; PMCID: PMC6553812.
    Citations: 42     Fields:    Translation:HumansCellsCTClinical Trials
  12. Ding L, Kim HJ, Wang Q, Kearns M, Jiang T, Ohlson CE, Li BB, Xie S, Liu JF, Stover EH, Howitt BE, Bronson RT, Lazo S, Roberts TM, Freeman GJ, Konstantinopoulos PA, Matulonis UA, Zhao JJ. PARP Inhibition Elicits STING-Dependent Antitumor Immunity in Brca1-Deficient Ovarian Cancer. Cell Rep. 2018 12 11; 25(11):2972-2980.e5. PMID: 30540933.
    Citations: 149     Fields:    Translation:HumansAnimalsCells
  13. Li BB, Qian C, Roberts TM, Zhao JJ. Targeted Profiling of RNA Translation. Curr Protoc Mol Biol. 2019 01; 125(1):e71. PMID: 30346115; PMCID: PMC6326074.
    Citations: 1     Fields:    Translation:HumansAnimalsCells
  14. Wang Y, Li BB, Li J, Roberts TM, Zhao JJ. A Conditional Dependency on MELK for the Proliferation of Triple-Negative Breast Cancer Cells. iScience. 2018 Nov 30; 9:149-160. PMID: 30391850; PMCID: PMC6215964.
    Citations: 8     
  15. Li BB, Qian C, Gameiro PA, Liu CC, Jiang T, Roberts TM, Struhl K, Zhao JJ. Targeted profiling of RNA translation reveals mTOR-4EBP1/2-independent translation regulation of mRNAs encoding ribosomal proteins. Proc Natl Acad Sci U S A. 2018 10 02; 115(40):E9325-E9332. PMID: 30224479; PMCID: PMC6176620.
    Citations: 10     Fields:    Translation:HumansCells
  16. Bergholz JS, Roberts TM, Zhao JJ. Isoform-Selective Phosphatidylinositol 3-Kinase Inhibition in Cancer. J Clin Oncol. 2018 05 01; 36(13):1339-1342. PMID: 29517943.
    Citations: 4     Fields:    Translation:Humans
  17. Goel S, DeCristo MJ, Watt AC, BrinJones H, Sceneay J, Li BB, Khan N, Ubellacker JM, Xie S, Metzger-Filho O, Hoog J, Ellis MJ, Ma CX, Ramm S, Krop IE, Winer EP, Roberts TM, Kim HJ, McAllister SS, Zhao JJ. CDK4/6 inhibition triggers anti-tumour immunity. Nature. 2017 08 24; 548(7668):471-475. PMID: 28813415; PMCID: PMC5570667.
    Citations: 436     Fields:    Translation:HumansAnimalsCells
  18. Zhang J, Gao X, Schmit F, Adelmant G, Eck MJ, Marto JA, Zhao JJ, Roberts TM. CRKL Mediates p110ß-Dependent PI3K Signaling in PTEN-Deficient Cancer Cells. Cell Rep. 2017 07 18; 20(3):549-557. PMID: 28723560.
    Citations: 15     Fields:    Translation:HumansCells
  19. Thorpe LM, Spangle JM, Ohlson CE, Cheng H, Roberts TM, Cantley LC, Zhao JJ. PI3K-p110a mediates the oncogenic activity induced by loss of the novel tumor suppressor PI3K-p85a. Proc Natl Acad Sci U S A. 2017 07 03; 114(27):7095-7100. PMID: 28630349; PMCID: PMC5502636.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  20. Spangle JM, Roberts TM. Epigenetic regulation of RTK signaling. J Mol Med (Berl). 2017 08; 95(8):791-798. PMID: 28589435; PMCID: PMC5663182.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  21. Spangle JM, Roberts TM, Zhao JJ. The emerging role of PI3K/AKT-mediated epigenetic regulation in cancer. Biochim Biophys Acta Rev Cancer. 2017 Aug; 1868(1):123-131. PMID: 28315368.
    Citations: 49     Fields:    Translation:HumansAnimalsCells
  22. Cizmecioglu O, Ni J, Xie S, Zhao JJ, Roberts TM. Rac1-mediated membrane raft localization of PI3K/p110ß is required for its activation by GPCRs or PTEN loss. Elife. 2016 10 04; 5. PMID: 27700986.
    Citations: 15     Fields:    Translation:AnimalsCells
  23. Yuzugullu H, Von T, Thorpe LM, Walker SR, Roberts TM, Frank DA, Zhao JJ. NTRK2 activation cooperates with PTEN deficiency in T-ALL through activation of both the PI3K-AKT and JAK-STAT3 pathways. Cell Discov. 2016; 2:16030. PMID: 27672444; PMCID: PMC5029543.
    Citations: 9     
  24. Rouleau C, Pores Fernando AT, Hwang JH, Faure N, Jiang T, White EA, Roberts TM, Schaffhausen BS. Transformation by Polyomavirus Middle T Antigen Involves a Unique Bimodal Interaction with the Hippo Effector YAP. J Virol. 2016 08 15; 90(16):7032-7045. PMID: 27194756; PMCID: PMC4984622.
    Citations: 10     Fields:    Translation:HumansAnimalsCells
  25. Wang D, Li C, Zhang Y, Wang M, Jiang N, Xiang L, Li T, Roberts TM, Zhao JJ, Cheng H, Liu P. Combined inhibition of PI3K and PARP is effective in the treatment of ovarian cancer cells with wild-type PIK3CA genes. Gynecol Oncol. 2016 09; 142(3):548-56. PMID: 27426307; PMCID: PMC5551048.
    Citations: 31     Fields:    Translation:HumansCells
  26. Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ. Tyrosine receptor kinase B is a drug target in astrocytomas. Neuro Oncol. 2017 01; 19(1):22-30. PMID: 27402815; PMCID: PMC5193024.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  27. Spangle JM, Dreijerink KM, Groner AC, Cheng H, Ohlson CE, Reyes J, Lin CY, Bradner J, Zhao JJ, Roberts TM, Brown M. PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer. Cell Rep. 2016 06 21; 15(12):2692-704. PMID: 27292631.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  28. Ni J, Ramkissoon SH, Xie S, Goel S, Stover DG, Guo H, Luu V, Marco E, Ramkissoon LA, Kang YJ, Hayashi M, Nguyen QD, Ligon AH, Du R, Claus EB, Alexander BM, Yuan GC, Wang ZC, Iglehart JD, Krop IE, Roberts TM, Winer EP, Lin NU, Ligon KL, Zhao JJ. Combination inhibition of PI3K and mTORC1 yields durable remissions in mice bearing orthotopic patient-derived xenografts of HER2-positive breast cancer brain metastases. Nat Med. 2016 07; 22(7):723-6. PMID: 27270588; PMCID: PMC4938731.
    Citations: 53     Fields:    Translation:HumansAnimalsCells
  29. Lee SJ, Kim MJ, Kwon IC, Roberts TM. Delivery strategies and potential targets for siRNA in major cancer types. Adv Drug Deliv Rev. 2016 09 01; 104:2-15. PMID: 27259398; PMCID: PMC4958528.
    Citations: 34     Fields:    Translation:Humans
  30. Wang D, Wang M, Jiang N, Zhang Y, Bian X, Wang X, Roberts TM, Zhao JJ, Liu P, Cheng H. Effective use of PI3K inhibitor BKM120 and PARP inhibitor Olaparib to treat PIK3CA mutant ovarian cancer. Oncotarget. 2016 Mar 15; 7(11):13153-66. PMID: 26909613.
    Citations: 34     Fields:    Translation:HumansAnimalsCells
  31. Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. Corrigendum: Essential roles of PI(3)K-p110ß in cell growth, metabolism and tumorigenesis. Nature. 2016 05 12; 533(7602):278. PMID: 26814969.
    Citations: 3     Fields:    
  32. Wang Q, Liu P, Spangle JM, Von T, Roberts TM, Lin NU, Krop IE, Winer EP, Zhao JJ. PI3K-p110a mediates resistance to HER2-targeted therapy in HER2+, PTEN-deficient breast cancers. Oncogene. 2016 07 07; 35(27):3607-12. PMID: 26500061.
    Citations: 23     Fields:    Translation:HumansAnimalsCells
  33. Yuzugullu H, Baitsch L, Von T, Steiner A, Tong H, Ni J, Clayton LK, Bronson R, Roberts TM, Gritsman K, Zhao JJ. A PI3K p110ß-Rac signalling loop mediates Pten-loss-induced perturbation of haematopoiesis and leukaemogenesis. Nat Commun. 2015 Oct 07; 6:8501. PMID: 26442967.
    Citations: 24     Fields:    Translation:AnimalsCells
  34. Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM. Correction for Hwang et al., Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. J Virol. 2015 Jul; 89(13):6971. PMID: 26041839; PMCID: PMC4468481.
    Citations:    Fields:    
  35. White EA, Kramer RE, Hwang JH, Pores Fernando AT, Naetar N, Hahn WC, Roberts TM, Schaffhausen BS, Livingston DM, Howley PM. Papillomavirus E7 oncoproteins share functions with polyomavirus small T antigens. J Virol. 2015 Mar; 89(5):2857-65. PMID: 25540383; PMCID: PMC4325735.
    Citations: 10     Fields:    Translation:HumansCells
  36. Csibi A, Lee G, Yoon SO, Tong H, Ilter D, Elia I, Fendt SM, Roberts TM, Blenis J. The mTORC1/S6K1 pathway regulates glutamine metabolism through the eIF4B-dependent control of c-Myc translation. Curr Biol. 2014 Oct 06; 24(19):2274-80. PMID: 25220053; PMCID: PMC4190129.
    Citations: 114     Fields:    Translation:HumansCells
  37. Hwang JH, Pores Fernando AT, Faure N, Andrabi S, Adelmant G, Hahn WC, Marto JA, Schaffhausen BS, Roberts TM. Polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation. J Virol. 2014 Oct; 88(20):12055-64. PMID: 25122798; PMCID: PMC4178709.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  38. Pores Fernando AT, Andrabi S, Cizmecioglu O, Zhu C, Livingston DM, Higgins JM, Schaffhausen BS, Roberts TM. Polyoma small T antigen triggers cell death via mitotic catastrophe. Oncogene. 2015 May 07; 34(19):2483-92. PMID: 24998850; PMCID: PMC4286542.
    Citations: 9     Fields:    Translation:HumansAnimalsCells
  39. Utermark T, Schmit F, Lee SH, Gao X, Schaffhausen BS, Roberts TM. The phosphatidylinositol 3-kinase (PI3K) isoform dependence of tumor formation is determined by the genetic mode of PI3K pathway activation rather than by tissue type. J Virol. 2014 Sep; 88(18):10673-9. PMID: 24991009.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  40. Shao DD, Xue W, Krall EB, Bhutkar A, Piccioni F, Wang X, Schinzel AC, Sood S, Rosenbluh J, Kim JW, Zwang Y, Roberts TM, Root DE, Jacks T, Hahn WC. KRAS and YAP1 converge to regulate EMT and tumor survival. Cell. 2014 Jul 03; 158(1):171-84. PMID: 24954536; PMCID: PMC4110062.
    Citations: 357     Fields:    Translation:HumansAnimalsCells
  41. Schmit F, Utermark T, Zhang S, Wang Q, Von T, Roberts TM, Zhao JJ. PI3K isoform dependence of PTEN-deficient tumors can be altered by the genetic context. Proc Natl Acad Sci U S A. 2014 Apr 29; 111(17):6395-400. PMID: 24737887.
    Citations: 37     Fields:    Translation:HumansAnimalsCells
  42. Gritsman K, Yuzugullu H, Von T, Yan H, Clayton L, Fritsch C, Maira SM, Hollingworth G, Choi C, Khandan T, Paktinat M, Okabe RO, Roberts TM, Zhao JJ. Hematopoiesis and RAS-driven myeloid leukemia differentially require PI3K isoform p110a. J Clin Invest. 2014 Apr; 124(4):1794-809. PMID: 24569456; PMCID: PMC3973083.
    Citations: 29     Fields:    Translation:HumansAnimalsCells
  43. Korpal M, Korn JM, Gao X, Rakiec DP, Ruddy DA, Doshi S, Yuan J, Kovats SG, Kim S, Cooke VG, Monahan JE, Stegmeier F, Roberts TM, Sellers WR, Zhou W, Zhu P. An F876L mutation in androgen receptor confers genetic and phenotypic resistance to MDV3100 (enzalutamide). Cancer Discov. 2013 Sep; 3(9):1030-43. PMID: 23842682.
    Citations: 232     Fields:    Translation:HumansCells
  44. Jia S, Gao X, Lee SH, Maira SM, Wu X, Stack EC, Signoretti S, Loda M, Zhao JJ, Roberts TM. Opposing effects of androgen deprivation and targeted therapy on prostate cancer prevention. Cancer Discov. 2013 Jan; 3(1):44-51. PMID: 23258246; PMCID: PMC3546223.
    Citations: 32     Fields:    Translation:Animals
  45. Hofmann I, Weiss A, Elain G, Schwaederle M, Sterker D, Romanet V, Schmelzle T, Lai A, Brachmann SM, Bentires-Alj M, Roberts TM, Sellers WR, Hofmann F, Maira SM. K-RAS mutant pancreatic tumors show higher sensitivity to MEK than to PI3K inhibition in vivo. PLoS One. 2012; 7(8):e44146. PMID: 22952903.
    Citations: 38     Fields:    Translation:HumansAnimalsCells
  46. Pugh TJ, Weeraratne SD, Archer TC, Pomeranz Krummel DA, Auclair D, Bochicchio J, Carneiro MO, Carter SL, Cibulskis K, Erlich RL, Greulich H, Lawrence MS, Lennon NJ, McKenna A, Meldrim J, Ramos AH, Ross MG, Russ C, Shefler E, Sivachenko A, Sogoloff B, Stojanov P, Tamayo P, Mesirov JP, Amani V, Teider N, Sengupta S, Francois JP, Northcott PA, Taylor MD, Yu F, Crabtree GR, Kautzman AG, Gabriel SB, Getz G, Jäger N, Jones DT, Lichter P, Pfister SM, Roberts TM, Meyerson M, Pomeroy SL, Cho YJ. Medulloblastoma exome sequencing uncovers subtype-specific somatic mutations. Nature. 2012 Aug 02; 488(7409):106-10. PMID: 22820256.
    Citations: 366     Fields:    Translation:HumansCells
  47. Utermark T, Rao T, Cheng H, Wang Q, Lee SH, Wang ZC, Iglehart JD, Roberts TM, Muller WJ, Zhao JJ. The p110a and p110ß isoforms of PI3K play divergent roles in mammary gland development and tumorigenesis. Genes Dev. 2012 Jul 15; 26(14):1573-86. PMID: 22802530.
    Citations: 78     Fields:    Translation:AnimalsCells
  48. Roberts TM, Stewart M. Role of major sperm protein (MSP) in the protrusion and retraction of Ascaris sperm. Int Rev Cell Mol Biol. 2012; 297:265-93. PMID: 22608562.
    Citations: 11     Fields:    Translation:AnimalsCells
  49. Shimabukuro K, Noda N, Stewart M, Roberts TM. Reconstitution of amoeboid motility in vitro identifies a motor-independent mechanism for cell body retraction. Curr Biol. 2011 Oct 25; 21(20):1727-31. PMID: 22000106; PMCID: PMC3210573.
    Citations: 5     Fields:    Translation:AnimalsCells
  50. Ilic N, Utermark T, Widlund HR, Roberts TM. PI3K-targeted therapy can be evaded by gene amplification along the MYC-eukaryotic translation initiation factor 4E (eIF4E) axis. Proc Natl Acad Sci U S A. 2011 Sep 13; 108(37):E699-708. PMID: 21876152; PMCID: PMC3174675.
    Citations: 120     Fields:    Translation:HumansCells
  51. Andrabi S, Hwang JH, Choe JK, Roberts TM, Schaffhausen BS. Comparisons between murine polyomavirus and Simian virus 40 show significant differences in small T antigen function. J Virol. 2011 Oct; 85(20):10649-58. PMID: 21835797.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  52. Zhang J, Roberts TM, Shivdasani RA. Targeting PI3K signaling as a therapeutic approach for colorectal cancer. Gastroenterology. 2011 Jul; 141(1):50-61. PMID: 21723986.
    Citations: 46     Fields:    Translation:HumansAnimalsCells
  53. Lee SH, Jia S, Zhu Y, Utermark T, Signoretti S, Loda M, Schaffhausen B, Roberts TM. Transgenic expression of polyomavirus middle T antigen in the mouse prostate gives rise to carcinoma. J Virol. 2011 Jun; 85(11):5581-92. PMID: 21411524.
    Citations: 3     Fields:    Translation:AnimalsCells
  54. Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, Emery CM, Stransky N, Cogdill AP, Barretina J, Caponigro G, Hieronymus H, Murray RR, Salehi-Ashtiani K, Hill DE, Vidal M, Zhao JJ, Yang X, Alkan O, Kim S, Harris JL, Wilson CJ, Myer VE, Finan PM, Root DE, Roberts TM, Golub T, Flaherty KT, Dummer R, Weber BL, Sellers WR, Schlegel R, Wargo JA, Hahn WC, Garraway LA. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature. 2010 Dec 16; 468(7326):968-72. PMID: 21107320; PMCID: PMC3058384.
    Citations: 688     Fields:    Translation:HumansCells
  55. Qi HH, Sarkissian M, Hu GQ, Wang Z, Bhattacharjee A, Gordon DB, Gonzales M, Lan F, Ongusaha PP, Huarte M, Yaghi NK, Lim H, Garcia BA, Brizuela L, Zhao K, Roberts TM, Shi Y. Histone H4K20/H3K9 demethylase PHF8 regulates zebrafish brain and craniofacial development. Nature. 2010 Jul 22; 466(7305):503-7. PMID: 20622853.
    Citations: 146     Fields:    Translation:HumansAnimalsCells
  56. Lee SH, Poulogiannis G, Pyne S, Jia S, Zou L, Signoretti S, Loda M, Cantley LC, Roberts TM. A constitutively activated form of the p110beta isoform of PI3-kinase induces prostatic intraepithelial neoplasia in mice. Proc Natl Acad Sci U S A. 2010 Jun 15; 107(24):11002-7. PMID: 20534477.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  57. Ilic N, Roberts TM. Comparing the roles of the p110a and p110ß isoforms of PI3K in signaling and cancer. Curr Top Microbiol Immunol. 2010; 347:55-77. PMID: 20517719.
    Citations: 8     Fields:    Translation:HumansAnimalsCells
  58. Liu P, Cheng H, Roberts TM, Zhao JJ. Targeting the phosphoinositide 3-kinase pathway in cancer. Nat Rev Drug Discov. 2009 Aug; 8(8):627-44. PMID: 19644473; PMCID: PMC3142564.
    Citations: 990     Fields:    Translation:HumansAnimalsCells
  59. Yi K, Wang X, Emmett MR, Marshall AG, Stewart M, Roberts TM. Dephosphorylation of major sperm protein (MSP) fiber protein 3 by protein phosphatase 2A during cell body retraction in the MSP-based amoeboid motility of Ascaris sperm. Mol Biol Cell. 2009 Jul; 20(14):3200-8. PMID: 19458186.
    Citations: 16     Fields:    Translation:AnimalsCells
  60. Jia S, Roberts TM, Zhao JJ. Should individual PI3 kinase isoforms be targeted in cancer? Curr Opin Cell Biol. 2009 Apr; 21(2):199-208. PMID: 19200708.
    Citations: 48     Fields:    Translation:HumansAnimalsCells
  61. Schaffhausen BS, Roberts TM. Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology. 2009 Feb 20; 384(2):304-16. PMID: 19022468.
    Citations: 30     Fields:    Translation:AnimalsCells
  62. Hein J, Boichuk S, Wu J, Cheng Y, Freire R, Jat PS, Roberts TM, Gjoerup OV. Simian virus 40 large T antigen disrupts genome integrity and activates a DNA damage response via Bub1 binding. J Virol. 2009 Jan; 83(1):117-27. PMID: 18922873; PMCID: PMC2612341.
    Citations: 66     Fields:    Translation:HumansCells
  63. Imamura S, Uchiyama J, Koshimizu E, Hanai J, Raftopoulou C, Murphey RD, Bayliss PE, Imai Y, Burns CE, Masutomi K, Gagos S, Zon LI, Roberts TM, Kishi S. A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis. PLoS One. 2008; 3(10):e3364. PMID: 18846223.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  64. Kishi S, Bayliss PE, Uchiyama J, Koshimizu E, Qi J, Nanjappa P, Imamura S, Islam A, Neuberg D, Amsterdam A, Roberts TM. The identification of zebrafish mutants showing alterations in senescence-associated biomarkers. PLoS Genet. 2008 Aug 15; 4(8):e1000152. PMID: 18704191.
    Citations: 63     Fields:    Translation:HumansAnimalsCells
  65. Jia S, Liu Z, Zhang S, Liu P, Zhang L, Lee SH, Zhang J, Signoretti S, Loda M, Roberts TM, Zhao JJ. Essential roles of PI(3)K-p110beta in cell growth, metabolism and tumorigenesis. Nature. 2008 Aug 07; 454(7205):776-9. PMID: 18594509.
    Citations: 334     Fields:    Translation:HumansAnimalsCells
  66. Miao L, Vanderlinde O, Liu J, Grant RP, Wouterse A, Shimabukuro K, Philipse A, Stewart M, Roberts TM. The role of filament-packing dynamics in powering amoeboid cell motility. Proc Natl Acad Sci U S A. 2008 Apr 08; 105(14):5390-5. PMID: 18385381.
    Citations: 6     Fields:    Translation:AnimalsCells
  67. Andrabi S, Gjoerup OV, Kean JA, Roberts TM, Schaffhausen B. Protein phosphatase 2A regulates life and death decisions via Akt in a context-dependent manner. Proc Natl Acad Sci U S A. 2007 Nov 27; 104(48):19011-6. PMID: 18006659.
    Citations: 54     Fields:    Translation:AnimalsCells
  68. Lan F, Bayliss PE, Rinn JL, Whetstine JR, Wang JK, Chen S, Iwase S, Alpatov R, Issaeva I, Canaani E, Roberts TM, Chang HY, Shi Y. A histone H3 lysine 27 demethylase regulates animal posterior development. Nature. 2007 Oct 11; 449(7163):689-94. PMID: 17851529.
    Citations: 361     Fields:    Translation:HumansAnimalsCells
  69. Boehm JS, Zhao JJ, Yao J, Kim SY, Firestein R, Dunn IF, Sjostrom SK, Garraway LA, Weremowicz S, Richardson AL, Greulich H, Stewart CJ, Mulvey LA, Shen RR, Ambrogio L, Hirozane-Kishikawa T, Hill DE, Vidal M, Meyerson M, Grenier JK, Hinkle G, Root DE, Roberts TM, Lander ES, Polyak K, Hahn WC. Integrative genomic approaches identify IKBKE as a breast cancer oncogene. Cell. 2007 Jun 15; 129(6):1065-79. PMID: 17574021.
    Citations: 322     Fields:    Translation:HumansCells
  70. Williams GL, Roberts TM, Gjoerup OV. Bub1: escapades in a cellular world. Cell Cycle. 2007 Jul 15; 6(14):1699-704. PMID: 17643075.
    Citations: 22     Fields:    Translation:HumansCells
  71. Gjoerup OV, Wu J, Chandler-Militello D, Williams GL, Zhao J, Schaffhausen B, Jat PS, Roberts TM. Surveillance mechanism linking Bub1 loss to the p53 pathway. Proc Natl Acad Sci U S A. 2007 May 15; 104(20):8334-9. PMID: 17488820; PMCID: PMC1895950.
    Citations: 31     Fields:    Translation:HumansCells
  72. Utermark T, Schaffhausen BS, Roberts TM, Zhao JJ. The p110alpha isoform of phosphatidylinositol 3-kinase is essential for polyomavirus middle T antigen-mediated transformation. J Virol. 2007 Jul; 81(13):7069-76. PMID: 17442716; PMCID: PMC1933267.
    Citations: 21     Fields:    Translation:HumansAnimalsCells
  73. Miao L, Yi K, Mackey JM, Roberts TM. Reconstitution in vitro of MSP-based filopodium extension in nematode sperm. Cell Motil Cytoskeleton. 2007 Apr; 64(4):235-47. PMID: 17183548.
    Citations: 2     Fields:    Translation:AnimalsCells
  74. Yi K, Buttery SM, Stewart M, Roberts TM. A Ser/Thr kinase required for membrane-associated assembly of the major sperm protein motility apparatus in the amoeboid sperm of Ascaris. Mol Biol Cell. 2007 May; 18(5):1816-25. PMID: 17344482; PMCID: PMC1855020.
    Citations: 15     Fields:    Translation:AnimalsCells
  75. Iwase S, Lan F, Bayliss P, de la Torre-Ubieta L, Huarte M, Qi HH, Whetstine JR, Bonni A, Roberts TM, Shi Y. The X-linked mental retardation gene SMCX/JARID1C defines a family of histone H3 lysine 4 demethylases. Cell. 2007 Mar 23; 128(6):1077-88. PMID: 17320160.
    Citations: 317     Fields:    Translation:HumansAnimalsCells
  76. Zhao JJ, Roberts TM. PI3 kinases in cancer: from oncogene artifact to leading cancer target. Sci STKE. 2006 Dec 12; 2006(365):pe52. PMID: 17164467.
    Citations: 18     Fields:    Translation:HumansAnimalsCells
  77. Zhao JJ, Cheng H, Jia S, Wang L, Gjoerup OV, Mikami A, Roberts TM. The p110alpha isoform of PI3K is essential for proper growth factor signaling and oncogenic transformation. Proc Natl Acad Sci U S A. 2006 Oct 31; 103(44):16296-300. PMID: 17060635; PMCID: PMC1637576.
    Citations: 108     Fields:    Translation:AnimalsCells
  78. Lin SS, Bassik MC, Suh H, Nishino M, Arroyo JD, Hahn WC, Korsmeyer SJ, Roberts TM. PP2A regulates BCL-2 phosphorylation and proteasome-mediated degradation at the endoplasmic reticulum. J Biol Chem. 2006 Aug 11; 281(32):23003-12. PMID: 16717086.
    Citations: 30     Fields:    Translation:HumansAnimalsCells
  79. Liu Z, Roberts TM. Human tumor mutants in the p110alpha subunit of PI3K. Cell Cycle. 2006 Apr; 5(7):675-7. PMID: 16627990.
    Citations: 18     Fields:    Translation:Humans
  80. Bayliss PE, Bellavance KL, Whitehead GG, Abrams JM, Aegerter S, Robbins HS, Cowan DB, Keating MT, O'Reilly T, Wood JM, Roberts TM, Chan J. Chemical modulation of receptor signaling inhibits regenerative angiogenesis in adult zebrafish. Nat Chem Biol. 2006 May; 2(5):265-73. PMID: 16565716; PMCID: PMC1534118.
    Citations: 46     Fields:    Translation:AnimalsCells
  81. Zhao JJ, Liu Z, Wang L, Shin E, Loda MF, Roberts TM. The oncogenic properties of mutant p110alpha and p110beta phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc Natl Acad Sci U S A. 2005 Dec 20; 102(51):18443-8. PMID: 16339315; PMCID: PMC1317954.
    Citations: 173     Fields:    Translation:HumansAnimalsCells
  82. Qa'dan M, Christensen KA, Zhang L, Roberts TM, Collier RJ. Membrane insertion by anthrax protective antigen in cultured cells. Mol Cell Biol. 2005 Jul; 25(13):5492-8. PMID: 15964805; PMCID: PMC1156972.
    Citations: 7     Fields:    Translation:AnimalsCells
  83. Westbrook TF, Martin ES, Schlabach MR, Leng Y, Liang AC, Feng B, Zhao JJ, Roberts TM, Mandel G, Hannon GJ, Depinho RA, Chin L, Elledge SJ. A genetic screen for candidate tumor suppressors identifies REST. Cell. 2005 Jun 17; 121(6):837-48. PMID: 15960972.
    Citations: 210     Fields:    Translation:HumansCells
  84. Rodriguez MA, LeClaire LL, Roberts TM. Preparing to move: assembly of the MSP amoeboid motility apparatus during spermiogenesis in Ascaris. Cell Motil Cytoskeleton. 2005 Apr; 60(4):191-9. PMID: 15751099.
    Citations: 3     Fields:    Translation:AnimalsCells
  85. Grant RP, Buttery SM, Ekman GC, Roberts TM, Stewart M. Structure of MFP2 and its function in enhancing MSP polymerization in Ascaris sperm amoeboid motility. J Mol Biol. 2005 Apr 01; 347(3):583-95. PMID: 15755452.
    Citations: 12     Fields:    Translation:AnimalsCells
  86. Roberts TM. Major sperm protein. Curr Biol. 2005 Mar 08; 15(5):R153. PMID: 15753021.
    Citations: 3     Fields:    Translation:AnimalsCells
  87. Stewart M, Roberts TM. Cytoskeleton dynamics powers nematode sperm motility. Adv Protein Chem. 2005; 71:383-99. PMID: 16230117.
    Citations: 5     Fields:    Translation:AnimalsCells
  88. Roberts TM. Comment on "observation of optical precursors in water". Phys Rev Lett. 2004 Dec 31; 93(26 Pt 1):269401. PMID: 15698042.
    Citations:    Fields:    
  89. Berger R, Febbo PG, Majumder PK, Zhao JJ, Mukherjee S, Signoretti S, Campbell KT, Sellers WR, Roberts TM, Loda M, Golub TR, Hahn WC. Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. Cancer Res. 2004 Dec 15; 64(24):8867-75. PMID: 15604246.
    Citations: 80     Fields:    Translation:HumansAnimalsCells
  90. Zhang L, Gjoerup O, Roberts TM. The serine/threonine kinase cyclin G-associated kinase regulates epidermal growth factor receptor signaling. Proc Natl Acad Sci U S A. 2004 Jul 13; 101(28):10296-301. PMID: 15240878; PMCID: PMC478566.
    Citations: 26     Fields:    Translation:HumansCells
  91. Zhao JJ, Roberts TM, Hahn WC. Functional genetics and experimental models of human cancer. Trends Mol Med. 2004 Jul; 10(7):344-50. PMID: 15242683.
    Citations: 20     Fields:    Translation:HumansAnimals
  92. Cotsiki M, Lock RL, Cheng Y, Williams GL, Zhao J, Perera D, Freire R, Entwistle A, Golemis EA, Roberts TM, Jat PS, Gjoerup OV. Simian virus 40 large T antigen targets the spindle assembly checkpoint protein Bub1. Proc Natl Acad Sci U S A. 2004 Jan 27; 101(4):947-52. PMID: 14732683; PMCID: PMC327122.
    Citations: 53     Fields:    Translation:AnimalsCells
  93. Kau TR, Schroeder F, Ramaswamy S, Wojciechowski CL, Zhao JJ, Roberts TM, Clardy J, Sellers WR, Silver PA. A chemical genetic screen identifies inhibitors of regulated nuclear export of a Forkhead transcription factor in PTEN-deficient tumor cells. Cancer Cell. 2003 Dec; 4(6):463-76. PMID: 14706338.
    Citations: 121     Fields:    Translation:HumansAnimalsCells
  94. Miao L, Vanderlinde O, Stewart M, Roberts TM. Retraction in amoeboid cell motility powered by cytoskeletal dynamics. Science. 2003 Nov 21; 302(5649):1405-7. PMID: 14631043.
    Citations: 23     Fields:    Translation:AnimalsCells
  95. Buttery SM, Ekman GC, Seavy M, Stewart M, Roberts TM. Dissection of the Ascaris sperm motility machinery identifies key proteins involved in major sperm protein-based amoeboid locomotion. Mol Biol Cell. 2003 Dec; 14(12):5082-8. PMID: 14565983; PMCID: PMC284809.
    Citations: 20     Fields:    Translation:AnimalsCells
  96. Hong YK, Mikami A, Schaffhausen B, Jun T, Roberts TM. A new class of mutations reveals a novel function for the original phosphatidylinositol 3-kinase binding site. Proc Natl Acad Sci U S A. 2003 Aug 05; 100(16):9434-9. PMID: 12881485; PMCID: PMC170936.
    Citations: 5     Fields:    Translation:AnimalsCells
  97. LeClaire LL, Stewart M, Roberts TM. A 48 kDa integral membrane phosphoprotein orchestrates the cytoskeletal dynamics that generate amoeboid cell motility in Ascaris sperm. J Cell Sci. 2003 Jul 01; 116(Pt 13):2655-63. PMID: 12746486.
    Citations: 18     Fields:    Translation:AnimalsCells
  98. Zhao JJ, Gjoerup OV, Subramanian RR, Cheng Y, Chen W, Roberts TM, Hahn WC. Human mammary epithelial cell transformation through the activation of phosphatidylinositol 3-kinase. Cancer Cell. 2003 May; 3(5):483-95. PMID: 12781366.
    Citations: 134     Fields:    Translation:HumansCells
  99. Baker AM, Roberts TM, Stewart M. 2.6 A resolution crystal structure of helices of the motile major sperm protein (MSP) of Caenorhabditis elegans. J Mol Biol. 2002 May 31; 319(2):491-9. PMID: 12051923.
    Citations: 9     Fields:    Translation:AnimalsCells
  100. Chan J, Bayliss PE, Wood JM, Roberts TM. Dissection of angiogenic signaling in zebrafish using a chemical genetic approach. Cancer Cell. 2002 Apr; 1(3):257-67. PMID: 12086862.
    Citations: 59     Fields:    Translation:AnimalsCells
  101. Luo H, Rose PE, Roberts TM, Dearolf CR. The Hopscotch Jak kinase requires the Raf pathway to promote blood cell activation and differentiation in Drosophila. Mol Genet Genomics. 2002 Mar; 267(1):57-63. PMID: 11919715.
    Citations: 22     Fields:    Translation:AnimalsCells
  102. Furman C, Short SM, Subramanian RR, Zetter BR, Roberts TM. DEF-1/ASAP1 is a GTPase-activating protein (GAP) for ARF1 that enhances cell motility through a GAP-dependent mechanism. J Biol Chem. 2002 Mar 08; 277(10):7962-9. PMID: 11773070.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  103. Gjoerup O, Zaveri D, Roberts TM. Induction of p53-independent apoptosis by simian virus 40 small t antigen. J Virol. 2001 Oct; 75(19):9142-55. PMID: 11533178; PMCID: PMC114483.
    Citations: 25     Fields:    Translation:HumansCells
  104. Chan J, Mably JD, Serluca FC, Chen JN, Goldstein NB, Thomas MC, Cleary JA, Brennan C, Fishman MC, Roberts TM. Morphogenesis of prechordal plate and notochord requires intact Eph/ephrin B signaling. Dev Biol. 2001 Jun 15; 234(2):470-82. PMID: 11397014.
    Citations: 27     Fields:    Translation:AnimalsCells
  105. Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. J Neurosci. 2001 Feb 15; 21(4):1110-6. PMID: 11160381; PMCID: PMC6762237.
    Citations: 44     Fields:    Translation:AnimalsCells
  106. Laham LE, Mukhopadhyay N, Roberts TM. The activation loop in Lck regulates oncogenic potential by inhibiting basal kinase activity and restricting substrate specificity. Oncogene. 2000 Aug 17; 19(35):3961-70. PMID: 10962552.
    Citations: 10     Fields:    Translation:HumansCells
  107. Auger KR, Wang J, Narsimhan RP, Holcombe T, Roberts TM. Constitutive cellular expression of PI 3-kinase is distinct from transient expression. Biochem Biophys Res Commun. 2000 Jun 16; 272(3):822-9. PMID: 10860837.
    Citations: 6     Fields:    Translation:AnimalsCells
  108. Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron. 2000 May; 26(2):405-16. PMID: 10839359.
    Citations: 37     Fields:    Translation:AnimalsCells
  109. Borghesani PR, Alt FW, Bottaro A, Davidson L, Aksoy S, Rathbun GA, Roberts TM, Swat W, Segal RA, Gu Y. Abnormal development of Purkinje cells and lymphocytes in Atm mutant mice. Proc Natl Acad Sci U S A. 2000 Mar 28; 97(7):3336-41. PMID: 10716718; PMCID: PMC16240.
    Citations: 92     Fields:    Translation:AnimalsCells
  110. Gjoerup O, Chao H, DeCaprio JA, Roberts TM. pRB-dependent, J domain-independent function of simian virus 40 large T antigen in override of p53 growth suppression. J Virol. 2000 Jan; 74(2):864-74. PMID: 10623749; PMCID: PMC111607.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  111. Jun T, Gjoerup O, Roberts TM. Tangled webs: evidence of cross-talk between c-Raf-1 and Akt. Sci STKE. 1999 Dec 21; 1999(13):PE1. PMID: 11865188.
    Citations: 17     Fields:    Translation:HumansAnimalsCells
  112. Altiok S, Batt D, Altiok N, Papautsky A, Downward J, Roberts TM, Avraham H. Heregulin induces phosphorylation of BRCA1 through phosphatidylinositol 3-Kinase/AKT in breast cancer cells. J Biol Chem. 1999 Nov 05; 274(45):32274-8. PMID: 10542266.
    Citations: 33     Fields:    Translation:HumansCells
  113. Alberta JA, Auger KR, Batt D, Iannarelli P, Hwang G, Elliott HL, Duke R, Roberts TM, Stiles CD. Platelet-derived growth factor stimulation of monocyte chemoattractant protein-1 gene expression is mediated by transient activation of the phosphoinositide 3-kinase signal transduction pathway. J Biol Chem. 1999 Oct 22; 274(43):31062-7. PMID: 10521506.
    Citations: 6     Fields:    Translation:AnimalsCells
  114. Aksoy IA, Ramsey MJ, Fruman DA, Aksoy S, Cantley LC, Tucker JD, Roberts TM. Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Biochem Biophys Res Commun. 1999 Aug 27; 262(2):438-42. PMID: 10462494.
    Citations:    Fields:    Translation:AnimalsCells
  115. Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM. Tyrosine phosphorylation of the proto-oncoprotein Raf-1 is regulated by Raf-1 itself and the phosphatase Cdc25A. Mol Cell Biol. 1999 Jul; 19(7):4819-24. PMID: 10373531.
    Citations: 7     Fields:    Translation:AnimalsCells
  116. Ramaswamy S, Nakamura N, Vazquez F, Batt DB, Perera S, Roberts TM, Sellers WR. Regulation of G1 progression by the PTEN tumor suppressor protein is linked to inhibition of the phosphatidylinositol 3-kinase/Akt pathway. Proc Natl Acad Sci U S A. 1999 Mar 02; 96(5):2110-5. PMID: 10051603; PMCID: PMC26745.
    Citations: 234     Fields:    Translation:HumansCells
  117. King FJ, Hu E, Harris DF, Sarraf P, Spiegelman BM, Roberts TM. DEF-1, a novel Src SH3 binding protein that promotes adipogenesis in fibroblastic cell lines. Mol Cell Biol. 1999 Mar; 19(3):2330-7. PMID: 10022919.
    Citations: 10     Fields:    Translation:AnimalsCells
  118. Liu W, Su W, Roberts TM. Discovery of estrogen-responsive genes using an improved method which combines subtractive hybridization and PCR. Nucleic Acids Res. 1998 Aug 01; 26(15):3616-8. PMID: 9671829; PMCID: PMC147722.
    Citations:    Fields:    Translation:HumansCells
  119. Batt DB, Roberts TM. Cell density modulates protein-tyrosine phosphorylation. J Biol Chem. 1998 Feb 06; 273(6):3408-14. PMID: 9452462.
    Citations: 7     Fields:    Translation:AnimalsCells
  120. Stubdal H, Zalvide J, Campbell KS, Schweitzer C, Roberts TM, DeCaprio JA. Inactivation of pRB-related proteins p130 and p107 mediated by the J domain of simian virus 40 large T antigen. Mol Cell Biol. 1997 Sep; 17(9):4979-90. PMID: 9271376.
    Citations: 82     Fields:    Translation:HumansAnimalsCells
  121. Campbell KS, Mullane KP, Aksoy IA, Stubdal H, Zalvide J, Pipas JM, Silver PA, Roberts TM, Schaffhausen BS, DeCaprio JA. DnaJ/hsp40 chaperone domain of SV40 large T antigen promotes efficient viral DNA replication. Genes Dev. 1997 May 01; 11(9):1098-110. PMID: 9159391.
    Citations: 96     Fields:    Translation:HumansAnimalsCells
  122. Williams BP, Park JK, Alberta JA, Muhlebach SG, Hwang GY, Roberts TM, Stiles CD. A PDGF-regulated immediate early gene response initiates neuronal differentiation in ventricular zone progenitor cells. Neuron. 1997 Apr; 18(4):553-62. PMID: 9136765.
    Citations: 35     Fields:    Translation:AnimalsCells
  123. Luo H, Rose P, Barber D, Hanratty WP, Lee S, Roberts TM, D'Andrea AD, Dearolf CR. Mutation in the Jak kinase JH2 domain hyperactivates Drosophila and mammalian Jak-Stat pathways. Mol Cell Biol. 1997 Mar; 17(3):1562-71. PMID: 9032284.
    Citations: 61     Fields:    Translation:AnimalsCells
  124. Barber DL, Corless CN, Xia K, Roberts TM, D'Andrea AD. Erythropoietin activates Raf1 by an Shc-independent pathway in CTLL-EPO-R cells. Blood. 1997 Jan 01; 89(1):55-64. PMID: 8978277.
    Citations: 7     Fields:    Translation:HumansAnimalsCells
  125. Xia K, Mukhopadhyay NK, Inhorn RC, Barber DL, Rose PE, Lee RS, Narsimhan RP, D'Andrea AD, Griffin JD, Roberts TM. The cytokine-activated tyrosine kinase JAK2 activates Raf-1 in a p21ras-dependent manner. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11681-6. PMID: 8876196; PMCID: PMC38118.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  126. Auger KR, Songyang Z, Lo SH, Roberts TM, Chen LB. Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes. J Biol Chem. 1996 Sep 20; 271(38):23452-7. PMID: 8798552.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  127. Nam HJ, Haser WG, Roberts TM, Frederick CA. Intramolecular interactions of the regulatory domains of the Bcr-Abl kinase reveal a novel control mechanism. Structure. 1996 Sep 15; 4(9):1105-14. PMID: 8805596.
    Citations: 12     Fields:    Translation:Cells
  128. Corbley MJ, Cherington V, Traxler PM, Lydon NB, Roberts TM. A strategy for screening anti-tumor drugs utilizing oncogenes encoded in retroviral vectors. Int J Cancer. 1996 Jun 11; 66(6):753-9. PMID: 8647645.
    Citations:    Fields:    Translation:AnimalsCells
  129. Jung JU, Lang SM, Jun T, Roberts TM, Veillette A, Desrosiers RC. Downregulation of Lck-mediated signal transduction by tip of herpesvirus saimiri. J Virol. 1995 Dec; 69(12):7814-22. PMID: 7494293; PMCID: PMC189725.
    Citations: 31     Fields:    Translation:HumansCells
  130. Jung JU, Lang SM, Friedrich U, Jun T, Roberts TM, Desrosiers RC, Biesinger B. Identification of Lck-binding elements in tip of herpesvirus saimiri. J Biol Chem. 1995 Sep 01; 270(35):20660-7. PMID: 7544793.
    Citations: 39     Fields:    Translation:AnimalsCells
  131. Agarwal S, Corbley MJ, Roberts TM. Reconstitution of signal transduction from the membrane to the nucleus in a baculovirus expression system: activation of Raf-1 leads to hypermodification of c-jun and c-fos via multiple pathways. Oncogene. 1995 Aug 03; 11(3):427-38. PMID: 7543194.
    Citations: 9     Fields:    Translation:AnimalsCells
  132. Campbell KS, Auger KR, Hemmings BA, Roberts TM, Pallas DC. Identification of regions in polyomavirus middle T and small t antigens important for association with protein phosphatase 2A. J Virol. 1995 Jun; 69(6):3721-8. PMID: 7538174; PMCID: PMC189088.
    Citations: 37     Fields:    Translation:AnimalsCells
  133. Wang J, Auger KR, Jarvis L, Shi Y, Roberts TM. Direct association of Grb2 with the p85 subunit of phosphatidylinositol 3-kinase. J Biol Chem. 1995 May 26; 270(21):12774-80. PMID: 7759531.
    Citations: 28     Fields:    Translation:HumansAnimalsCells
  134. Su W, Liu W, Schaffhausen BS, Roberts TM. Association of Polyomavirus middle tumor antigen with phospholipase C-gamma 1. J Biol Chem. 1995 May 26; 270(21):12331-4. PMID: 7759472.
    Citations: 37     Fields:    Translation:AnimalsCells
  135. Corbley MJ, Cherington V, Feig LA, Cooper GM, Roberts TM. Rapid regeneration of virus from cells infected with a retroviral vector. Biotechniques. 1994 Dec; 17(6):1102-3, 1106-9. PMID: 7873180.
    Citations:    Fields:    Translation:AnimalsCells
  136. Fu H, Xia K, Pallas DC, Cui C, Conroy K, Narsimhan RP, Mamon H, Collier RJ, Roberts TM. Interaction of the protein kinase Raf-1 with 14-3-3 proteins. Science. 1994 Oct 07; 266(5182):126-9. PMID: 7939632.
    Citations: 65     Fields:    Translation:HumansAnimalsCells
  137. Pallas DC, Fu H, Haehnel LC, Weller W, Collier RJ, Roberts TM. Association of polyomavirus middle tumor antigen with 14-3-3 proteins. Science. 1994 Jul 22; 265(5171):535-7. PMID: 8036498.
    Citations: 42     Fields:    Translation:HumansAnimalsCells
  138. Campbell KS, Ogris E, Burke B, Su W, Auger KR, Druker BJ, Schaffhausen BS, Roberts TM, Pallas DC. Polyoma middle tumor antigen interacts with SHC protein via the NPTY (Asn-Pro-Thr-Tyr) motif in middle tumor antigen. Proc Natl Acad Sci U S A. 1994 Jul 05; 91(14):6344-8. PMID: 8022784; PMCID: PMC44198.
    Citations: 61     Fields:    Translation:HumansAnimalsCells
  139. Williams NG, Roberts TM. Signal transduction pathways involving the Raf proto-oncogene. Cancer Metastasis Rev. 1994 Mar; 13(1):105-16. PMID: 8143342.
    Citations: 16     Fields:    Translation:HumansAnimalsCells
  140. Wood KW, Roberts TM. Oncogenes and protein kinases in neuronal growth-factor action. Biochim Biophys Acta. 1993 Aug 23; 1155(2):133-50. PMID: 8357824.
    Citations: 5     Fields:    Translation:AnimalsCells
  141. Williams NG, Paradis H, Agarwal S, Charest DL, Pelech SL, Roberts TM. Raf-1 and p21v-ras cooperate in the activation of mitogen-activated protein kinase. Proc Natl Acad Sci U S A. 1993 Jun 15; 90(12):5772-6. PMID: 8390681; PMCID: PMC46804.
    Citations: 33     Fields:    Translation:AnimalsCells
  142. Wood KW, Qi H, D'Arcangelo G, Armstrong RC, Roberts TM, Halegoua S. The cytoplasmic raf oncogene induces a neuronal phenotype in PC12 cells: a potential role for cellular raf kinases in neuronal growth factor signal transduction. Proc Natl Acad Sci U S A. 1993 Jun 01; 90(11):5016-20. PMID: 8389463; PMCID: PMC46644.
    Citations: 52     Fields:    Translation:AnimalsCells
  143. Carrera AC, Alexandrov K, Roberts TM. The conserved lysine of the catalytic domain of protein kinases is actively involved in the phosphotransfer reaction and not required for anchoring ATP. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):442-6. PMID: 8421674; PMCID: PMC45679.
    Citations: 70     Fields:    Translation:Cells
  144. Carrera AC, Wee SB, Roberts TM, Pardoll DM. Selective association between MHC class I-restricted T cell receptors, CDS, and activated tyrosine kinases on thymocytes undergoing positive selection. J Immunol. 1992 Nov 15; 149(10):3142-9. PMID: 1431093.
    Citations: 2     Fields:    Translation:AnimalsCells
  145. Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Synthetic phosphopeptide immunogens yield activation-specific antibodies to the c-erbB-2 receptor. Proc Natl Acad Sci U S A. 1992 Nov 01; 89(21):10435-9. PMID: 1359539; PMCID: PMC50353.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  146. West AB, Roberts TM, Kolodner RD. Regulation of the reverse transcriptase of human immunodeficiency virus type 1 by dNTPs. Proc Natl Acad Sci U S A. 1992 Oct 15; 89(20):9720-4. PMID: 1384060; PMCID: PMC50204.
    Citations: 4     Fields:    Translation:Cells
  147. Druker BJ, Sibert L, Roberts TM. Polyomavirus middle T-antigen NPTY mutants. J Virol. 1992 Oct; 66(10):5770-6. PMID: 1326642; PMCID: PMC241452.
    Citations: 13     Fields:    Translation:AnimalsCells
  148. Carrera AC, Baker C, Roberts TM, Pardoll DM. Tyrosine kinase triggering in thymocytes undergoing positive selection. Eur J Immunol. 1992 Sep; 22(9):2289-94. PMID: 1516620.
    Citations:    Fields:    Translation:AnimalsCells
  149. Williams NG, Roberts TM, Li P. Both p21ras and pp60v-src are required, but neither alone is sufficient, to activate the Raf-1 kinase. Proc Natl Acad Sci U S A. 1992 Apr 01; 89(7):2922-6. PMID: 1372995; PMCID: PMC48775.
    Citations: 50     Fields:    Translation:AnimalsCells
  150. Wood KW, Sarnecki C, Roberts TM, Blenis J. ras mediates nerve growth factor receptor modulation of three signal-transducing protein kinases: MAP kinase, Raf-1, and RSK. Cell. 1992 Mar 20; 68(6):1041-50. PMID: 1312393.
    Citations: 244     Fields:    Translation:AnimalsCells
  151. Epstein RJ, Druker BJ, Irminger JC, Jones SD, Roberts TM, Stiles CD. Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts. Cell Growth Differ. 1992 Mar; 3(3):157-64. PMID: 1352989.
    Citations:    Fields:    Translation:AnimalsCells
  152. Ling LE, Druker BJ, Cantley LC, Roberts TM. Transformation-defective mutants of polyomavirus middle T antigen associate with phosphatidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells. J Virol. 1992 Mar; 66(3):1702-8. PMID: 1371171; PMCID: PMC240916.
    Citations: 26     Fields:    Translation:Cells
  153. Pallas DC, Weller W, Jaspers S, Miller TB, Lane WS, Roberts TM. The third subunit of protein phosphatase 2A (PP2A), a 55-kilodalton protein which is apparently substituted for by T antigens in complexes with the 36- and 63-kilodalton PP2A subunits, bears little resemblance to T antigens. J Virol. 1992 Feb; 66(2):886-93. PMID: 1370560; PMCID: PMC240789.
    Citations: 35     Fields:    Translation:AnimalsCells
  154. Ramer SE, Winkler DG, Carrera A, Roberts TM, Walsh CT. Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proc Natl Acad Sci U S A. 1991 Jul 15; 88(14):6254-8. PMID: 2068105; PMCID: PMC52061.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  155. Longnecker R, Druker B, Roberts TM, Kieff E. An Epstein-Barr virus protein associated with cell growth transformation interacts with a tyrosine kinase. J Virol. 1991 Jul; 65(7):3681-92. PMID: 1710288; PMCID: PMC241385.
    Citations: 54     Fields:    Translation:HumansCells
  156. Carrera AC, Li P, Roberts TM. Characterization of an active, non-myristylated, cytoplasmic form of the lymphoid protein tyrosine kinase pp56lck. Int Immunol. 1991 Jul; 3(7):673-82. PMID: 1911540.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  157. Davis S, Lu ML, Lo SH, Lin S, Butler JA, Druker BJ, Roberts TM, An Q, Chen LB. Presence of an SH2 domain in the actin-binding protein tensin. Science. 1991 May 03; 252(5006):712-5. PMID: 1708917.
    Citations: 78     Fields:    Translation:AnimalsCells
  158. Kanakura Y, Druker B, Wood KW, Mamon HJ, Okuda K, Roberts TM, Griffin JD. Granulocyte-macrophage colony-stimulating factor and interleukin-3 induce rapid phosphorylation and activation of the proto-oncogene Raf-1 in a human factor-dependent myeloid cell line. Blood. 1991 Jan 15; 77(2):243-8. PMID: 1845931.
    Citations: 20     Fields:    Translation:HumansCells
  159. Herrera R, Agarwal S, Walton K, Satterberg B, Distel RJ, Goodman R, Spiegelman BM, Roberts TM. A direct role for c-fos in AP-1-dependent gene transcription. Cell Growth Differ. 1990 Oct; 1(10):483-90. PMID: 2126190.
    Citations: 9     Fields:    Translation:AnimalsCells
  160. Druker BJ, Ling LE, Cohen B, Roberts TM, Schaffhausen BS. A completely transformation-defective point mutant of polyomavirus middle T antigen which retains full associated phosphatidylinositol kinase activity. J Virol. 1990 Sep; 64(9):4454-61. PMID: 2166824; PMCID: PMC247915.
    Citations: 25     Fields:    Translation:AnimalsCells
  161. Epstein RJ, Druker BJ, Roberts TM, Stiles CD. Modulation of a Mr 175,000 c-neu receptor isoform in G8/DHFR cells by serum starvation. J Biol Chem. 1990 Jun 25; 265(18):10746-51. PMID: 1972380.
    Citations: 8     Fields:    Translation:AnimalsCells
  162. Jin YJ, Kaplan DR, White M, Spagnoli GC, Roberts TM, Reinherz EL. Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line. J Immunol. 1990 Jan 15; 144(2):647-52. PMID: 1688582.
    Citations: 6     Fields:    Translation:HumansCells
  163. Pallas DC, Shahr