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Jane Anne Leopold, M.D.

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Research
The research activities and funding listed below are automatically derived from NIH ExPORTER and other sources, which might result in incorrect or missing items. Faculty can login to make corrections and additions.
  1. U01HL125215 (LEOPOLD, JANE A) Sep 17, 2014 - Jul 31, 2019
    NIH/NHLBI
    Intergrated Endothelial Phenotyping to Redefine Pulmonary Hypertension
    Role: Principal Investigator
  2. R01HL105301 (LEOPOLD, JANE A) Sep 20, 2010 - Jun 30, 2014
    NIH/NHLBI
    Aldosterone, Autophagy, and Arterial Stiffness
    Role: Principal Investigator
  3. K02HL081110 (LEOPOLD, JANE A) Sep 15, 2005 - Aug 31, 2010
    NIH/NHLBI
    Aldosterone, G6PD, and Vascular Endothelial Function
    Role: Principal Investigator
  4. U54HL070819 (STEINBERG, MARTIN H.) Jul 1, 2003 - Mar 31, 2012
    NIH/NHLBI
    Boston Comprehensive Sickle Cell Center
    Role: Co-Principal Investigator
  5. K08HL004399 (LEOPOLD, JANE A) Sep 1, 2000 - Jul 31, 2005
    NIH/NHLBI
    G6PD AND OXIDANT STRESS IN VASCULAR SMOOTH MUSCLE CELLS
    Role: Principal Investigator

Bibliographic
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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  1. Leopold JA, Maron BA. Precision Medicine in Pulmonary Arterial Hypertension. Circ Res. 2019 Mar 15; 124(6):832-833. PMID: 30870130.
    Citations:    
  2. Gounley J, Draeger EW, Oppelstrup T, Krauss WD, Gunnels JA, Chaudhury R, Nair P, Frakes D, Leopold JA, Randles A. Computing the ankle-brachial index with parallel computational fluid dynamics. J Biomech. 2019 01 03; 82:28-37. PMID: 30385003.
    Citations:    Fields:    
  3. Watanabe S, Ishikawa K, Plataki M, Bikou O, Kohlbrenner E, Aguero J, Hadri L, Zarragoikoetxea I, Fish K, Leopold JA, Hajjar RJ. Safety and long-term efficacy of AAV1.SERCA2a using nebulizer delivery in a pig model of pulmonary hypertension. Pulm Circ. 2018 Oct-Dec; 8(4):2045894018799738. PMID: 30129881.
    Citations: 1     
  4. Elinoff JM, Agarwal R, Barnett CF, Benza RL, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Rosenzweig EB, Shlobin OA, Steen VD, Zamanian RT, Solomon MA. Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg. A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report. Am J Respir Crit Care Med. 2018 Jul 15; 198(2):166-174. PMID: 29425462.
    Citations: 1     Fields:    
  5. Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA. NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension. Sci Transl Med. 2018 Jun 13; 10(445). PMID: 29899023.
    Citations:    
  6. Velagapudi P, Turagam M, Kolte D, Khera S, Hyder O, Gordon P, Aronow HD, Leopold J, Abbott JD. Intramyocardial autologous CD34+ cell therapy for refractory angina: A meta-analysis of randomized controlled trials. Cardiovasc Revasc Med. 2019 Mar; 20(3):215-219. PMID: 29908826.
    Citations:    Fields:    
  7. Faxon DP, Leopold JA, Abbott JD, McElhinney DB, Williams DO. Circulation: Cardiovascular Interventions: The First 10 Years. Circ Cardiovasc Interv. 2018 Jun; 11(6):e006901. PMID: 29895606.
    Citations:    Fields:    
  8. Leopold JA, Loscalzo J. Emerging Role of Precision Medicine in Cardiovascular Disease. Circ Res. 2018 Apr 27; 122(9):1302-1315. PMID: 29700074.
    Citations:    Fields:    
  9. Leopold JA. Pulmonary Venous Remodeling in Pulmonary Hypertension: The Veins Take Center Stage. Circulation. 2018 04 24; 137(17):1811-1813. PMID: 29685930.
    Citations:    Fields:    
  10. Leopold JA. Editorial commentary: Diagnosing spontaneous coronary artery dissection in women: A call for early coronary angiography. Trends Cardiovasc Med. 2018 07; 28(5):346-347. PMID: 29661711.
    Citations:    Fields:    Translation:Humans
  11. Oldham WM, Oliveira RKF, Wang RS, Opotowsky AR, Rubins DM, Hainer J, Wertheim BM, Alba GA, Choudhary G, Tornyos A, MacRae CA, Loscalzo J, Leopold JA, Waxman AB, Olschewski H, Kovacs G, Systrom DM, Maron BA. Network Analysis to Risk Stratify Patients With Exercise Intolerance. Circ Res. 2018 Mar 16; 122(6):864-876. PMID: 29437835.
    Citations:    Fields:    
  12. Oh YS, Berkowitz DE, Cohen RA, Figueroa CA, Harrison DG, Humphrey JD, Larson DF, Leopold JA, Mecham RP, Ruiz-Opazo N, Santhanam L, Seta F, Shyy JYJ, Sun Z, Tsao PS, Wagenseil JE, Galis ZS. A Special Report on the NHLBI Initiative to Study Cellular and Molecular Mechanisms of Arterial Stiffness and Its Association With Hypertension. Circ Res. 2017 11 10; 121(11):1216-1218. PMID: 29122942.
    Citations:    Fields:    
  13. Hemnes AR, Beck GJ, Newman JH, Abidov A, Aldred MA, Barnard J, Berman Rosenzweig E, Borlaug BA, Chung WK, Comhair SAA, Erzurum SC, Frantz RP, Gray MP, Grunig G, Hassoun PM, Hill NS, Horn EM, Hu B, Lempel JK, Maron BA, Mathai SC, Olman MA, Rischard FP, Systrom DM, Tang WHW, Waxman AB, Xiao L, Yuan JX, Leopold JA. PVDOMICS: A Multi-Center Study to Improve Understanding of Pulmonary Vascular Disease Through Phenomics. Circ Res. 2017 10 27; 121(10):1136-1139. PMID: 29074534.
    Citations: 6     Fields:    
  14. Randles A, Frakes DH, Leopold JA. Computational Fluid Dynamics and Additive Manufacturing to Diagnose and Treat Cardiovascular Disease. Trends Biotechnol. 2017 11; 35(11):1049-1061. PMID: 28942268.
    Citations:    Fields:    Translation:HumansAnimals
  15. Prosnitz AR, Leopold J, Irons M, Jenkins K, Roberts AE. Pulmonary vein stenosis in patients with Smith-Lemli-Opitz syndrome. Congenit Heart Dis. 2017 Jul; 12(4):475-483. PMID: 28719049.
    Citations:    Fields:    Translation:Humans
  16. Newman JH, Rich S, Abman SH, Alexander JH, Barnard J, Beck GJ, Benza RL, Bull TM, Chan SY, Chun HJ, Doogan D, Dupuis J, Erzurum SC, Frantz RP, Geraci M, Gillies H, Gladwin M, Gray MP, Hemnes AR, Herbst RS, Hernandez AF, Hill NS, Horn EM, Hunter K, Jing ZC, Johns R, Kaul S, Kawut SM, Lahm T, Leopold JA, Lewis GD, Mathai SC, McLaughlin VV, Michelakis ED, Nathan SD, Nichols W, Page G, Rabinovitch M, Rich J, Rischard F, Rounds S, Shah SJ, Tapson VF, Lowy N, Stockbridge N, Weinmann G, Xiao L. Enhancing Insights into Pulmonary Vascular Disease through a Precision Medicine Approach. A Joint NHLBI-Cardiovascular Medical Research and Education Fund Workshop Report. Am J Respir Crit Care Med. 2017 06 15; 195(12):1661-1670. PMID: 28430547.
    Citations: 9     Fields:    Translation:Humans
  17. Mangione FM, Jatene T, Badr Eslam R, Bergmark BA, Gallagher JR, Shah PB, Mauri L, Leopold JA, Sobieszczyk PS, Faxon DP, Croce KJ, Bhatt DL, Devlin PM. Usefulness of Intracoronary Brachytherapy for Patients With Resistant Drug-Eluting Stent Restenosis. Am J Cardiol. 2017 Aug 01; 120(3):369-373. PMID: 28583681.
    Citations:    Fields:    Translation:Humans
  18. Badr Eslam R, Croce K, Mangione FM, Musmann R, Leopold JA, Mitchell RN, Waxman AB. Persistence and proliferation of human mesenchymal stromal cells in the right ventricular myocardium after intracoronary injection in a large animal model of pulmonary hypertension. Cytotherapy. 2017 06; 19(6):668-679. PMID: 28392314.
    Citations:    Fields:    Translation:HumansAnimalsCells
  19. Leopold JA. Biological Phenotyping of Combined Post-Capillary and Pre-Capillary Pulmonary Hypertension: Focus on Pulmonary Vascular Remodeling. J Am Coll Cardiol. 2016 12 13; 68(23):2537-2539. PMID: 27931610.
    Citations: 2     Fields:    Translation:Humans
  20. Vaduganathan M, Qamar A, Singh A, Venkateswaran RV, Szumita PM, Croce KJ, Mauri L, Leopold JA, Shah PB, Sobieszczyk P, Faxon DP, Bhatt DL. Cangrelor Use Since FDA Approval: A Single-Center, Real-World Experience at a Tertiary Care Hospital. J Am Coll Cardiol. 2017 01 31; 69(4):463-464. PMID: 27914699.
    Citations:    Fields:    
  21. Beckman JA, Goldfine AB, Leopold JA, Creager MA. Ebselen does not improve oxidative stress and vascular function in patients with diabetes: a randomized, crossover trial. Am J Physiol Heart Circ Physiol. 2016 12 01; 311(6):H1431-H1436. PMID: 27765750.
    Citations:    Fields:    Translation:Humans
  22. Leopold JA. Catheter-Based Therapy for Inoperable Chronic Thromboembolic Pulmonary Hypertension. Circ Cardiovasc Interv. 2016 10; 9(10). PMID: 27765803.
    Citations:    Fields:    
  23. Maron BA, Leopold JA. Systems biology: An emerging strategy for discovering novel pathogenetic mechanisms that promote cardiovascular disease. Glob Cardiol Sci Pract. 2016 Sep 30; 2016(3):e201627. PMID: 29043273.
    Citations: 1     
  24. Baudrand R, Gupta N, Garza AE, Vaidya A, Leopold JA, Hopkins PN, Jeunemaitre X, Ferri C, Romero JR, Williams J, Loscalzo J, Adler GK, Williams GH, Pojoga LH. Caveolin 1 Modulates Aldosterone-Mediated Pathways of Glucose and Lipid Homeostasis. J Am Heart Assoc. 2016 09 28; 5(10). PMID: 27680666.
    Citations: 6     Fields:    Translation:HumansAnimalsCells
  25. Kinlay S, Michel T, Leopold JA. The Future of Vascular Biology and Medicine. Circulation. 2016 Jun 21; 133(25):2603-9. PMID: 27324355.
    Citations: 6     Fields:    Translation:HumansAnimals
  26. Leopold JA. Reply: Understanding vascular calcification from an evolutionary approach. Trends Cardiovasc Med. 2017 01; 27(1):70-71. PMID: 27396551.
    Citations:    Fields:    Translation:Humans
  27. Leopold JA. Whole-exome sequencing for the discovery of rare genetic variants that protect from coronary artery disease. Coron Artery Dis. 2016 06; 27(4):253-4. PMID: 27104937.
    Citations:    Fields:    Translation:Humans
  28. Leopold JA, Maron BA. Molecular Mechanisms of Pulmonary Vascular Remodeling in Pulmonary Arterial Hypertension. Int J Mol Sci. 2016 May 18; 17(5). PMID: 27213345.
    Citations: 8     Fields:    Translation:HumansCells
  29. Aguero J, Ishikawa K, Hadri L, Santos-Gallego CG, Fish KM, Kohlbrenner E, Hammoudi N, Kho C, Lee A, Ibáñez B, García-Alvarez A, Zsebo K, Maron BA, Plataki M, Fuster V, Leopold JA, Hajjar RJ. Intratracheal Gene Delivery of SERCA2a Ameliorates Chronic Post-Capillary Pulmonary Hypertension: A Large Animal Model. J Am Coll Cardiol. 2016 05 03; 67(17):2032-46. PMID: 27126531.
    Citations: 8     Fields:    Translation:AnimalsCells
  30. Aghamohammadzadeh R, Zhang YY, Stephens TE, Arons E, Zaman P, Polach KJ, Matar M, Yung LM, Yu PB, Bowman FP, Opotowsky AR, Waxman AB, Loscalzo J, Leopold JA, Maron BA. Up-regulation of the mammalian target of rapamycin complex 1 subunit Raptor by aldosterone induces abnormal pulmonary artery smooth muscle cell survival patterns to promote pulmonary arterial hypertension. FASEB J. 2016 07; 30(7):2511-27. PMID: 27006450.
    Citations: 5     Fields:    Translation:HumansAnimalsCells
  31. Maron BA, Hess E, Maddox TM, Opotowsky AR, Tedford RJ, Lahm T, Joynt KE, Kass DJ, Stephens T, Stanislawski MA, Swenson ER, Goldstein RH, Leopold JA, Zamanian RT, Elwing JM, Plomondon ME, Grunwald GK, Barón AE, Rumsfeld JS, Choudhary G. Association of Borderline Pulmonary Hypertension With Mortality and Hospitalization in a Large Patient Cohort: Insights From the Veterans Affairs Clinical Assessment, Reporting, and Tracking Program. Circulation. 2016 Mar 29; 133(13):1240-8. PMID: 26873944.
    Citations: 29     Fields:    Translation:Humans
  32. Berry NC, Manyoo A, Oldham WM, Stephens TE, Goldstein RH, Waxman AB, Tracy JA, Leary PJ, Leopold JA, Kinlay S, Opotowsky AR, Systrom DM, Maron BA. Protocol for exercise hemodynamic assessment: performing an invasive cardiopulmonary exercise test in clinical practice. Pulm Circ. 2015 Dec; 5(4):610-8. PMID: 26697168.
    Citations: 6     
  33. Leopold JA. Catheter-based therapies for patients with medication-refractory pulmonary arterial hypertension. Circ Cardiovasc Interv. 2015 Nov; 8(11):e003332. PMID: 26553702.
    Citations: 2     Fields:    Translation:HumansAnimals
  34. Maron BA, Stephens TE, Farrell LA, Oldham WM, Loscalzo J, Leopold JA, Lewis GD. Elevated pulmonary arterial and systemic plasma aldosterone levels associate with impaired cardiac reserve capacity during exercise in left ventricular systolic heart failure patients: A pilot study. J Heart Lung Transplant. 2016 Mar; 35(3):342-351. PMID: 26586488.
    Citations: 4     Fields:    Translation:Humans
  35. Maron BA, Leopold JA. Emerging Concepts in the Molecular Basis of Pulmonary Arterial Hypertension: Part II: Neurohormonal Signaling Contributes to the Pulmonary Vascular and Right Ventricular Pathophenotype of Pulmonary Arterial Hypertension. Circulation. 2015 Jun 09; 131(23):2079-91. PMID: 26056345.
    Citations: 14     Fields:    Translation:HumansCells
  36. Leopold JA. The Central Role of Neutrophil Gelatinase-Associated Lipocalin in Cardiovascular Fibrosis. Hypertension. 2015 Jul; 66(1):20-2. PMID: 25987663.
    Citations: 1     Fields:    Translation:HumansAnimals
  37. Aguero J, Ishikawa K, Fish KM, Hammoudi N, Hadri L, Garcia-Alvarez A, Ibanez B, Fuster V, Hajjar RJ, Leopold JA. Combination proximal pulmonary artery coiling and distal embolization induces chronic elevations in pulmonary artery pressure in Swine. PLoS One. 2015; 10(4):e0124526. PMID: 25923775.
    Citations: 2     Fields:    Translation:HumansAnimalsCells
  38. Leopold JA. Antioxidants and coronary artery disease: from pathophysiology to preventive therapy. Coron Artery Dis. 2015 Mar; 26(2):176-83. PMID: 25369999.
    Citations: 7     Fields:    Translation:Humans
  39. Leopold JA, Maron BA. New thematic series: recent advances in pulmonary hypertension. Circulation. 2014 Nov 11; 130(20):1771. PMID: 25385935.
    Citations:    
  40. Leopold JA. Vascular calcification: Mechanisms of vascular smooth muscle cell calcification. Trends Cardiovasc Med. 2015 May; 25(4):267-74. PMID: 25435520.
    Citations: 28     Fields:    Translation:HumansCells
  41. Leopold JA. MicroRNAs Regulate Vascular Medial Calcification. Cells. 2014 Oct 14; 3(4):963-80. PMID: 25317928.
    Citations: 9     
  42. Leopold JA. Obesity-related cardiomyopathy is an adipocyte-mediated paracrine disease. Trends Cardiovasc Med. 2015 Feb; 25(2):127-8. PMID: 25454380.
    Citations: 2     Fields:    Translation:Humans
  43. Leopold JA. Neoatherosclerosis: another consequence of endothelial dysfunction? Circ Cardiovasc Interv. 2014 Oct; 7(5):635-7. PMID: 25336601.
    Citations: 2     Fields:    Translation:HumansAnimals
  44. Kaneko T, Newburger JW, Leopold JA. Multivessel giant coronary artery aneurysms in an adult with an acute coronary syndrome: latent finding of Kawasaki disease. J Invasive Cardiol. 2014 Sep; 26(9):E127-9. PMID: 25198497.
    Citations:    Fields:    Translation:Humans
  45. Aguero J, Ishikawa K, Hadri L, Santos-Gallego C, Fish K, Hammoudi N, Chaanine A, Torquato S, Naim C, Ibanez B, Pereda D, García-Alvarez A, Fuster V, Sengupta PP, Leopold JA, Hajjar RJ. Characterization of right ventricular remodeling and failure in a chronic pulmonary hypertension model. Am J Physiol Heart Circ Physiol. 2014 Oct 15; 307(8):H1204-15. PMID: 25158063.
    Citations: 16     Fields:    Translation:Animals
  46. Leopold JA. Microvascular dysfunction: genetic polymorphisms suggest sex-specific differences in disease phenotype. Coron Artery Dis. 2014 Jun; 25(4):275-6. PMID: 24762819.
    Citations:    Fields:    Translation:Humans
  47. Maron BA, Leopold JA. The role of the renin-angiotensin-aldosterone system in the pathobiology of pulmonary arterial hypertension (2013 Grover Conference series). Pulm Circ. 2014 Jun; 4(2):200-10. PMID: 25006439.
    Citations: 12     
  48. Maron BA, Oldham WM, Chan SY, Vargas SO, Arons E, Zhang YY, Loscalzo J, Leopold JA. Upregulation of steroidogenic acute regulatory protein by hypoxia stimulates aldosterone synthesis in pulmonary artery endothelial cells to promote pulmonary vascular fibrosis. Circulation. 2014 Jul 08; 130(2):168-79. PMID: 25001622.
    Citations: 14     Fields:    Translation:HumansAnimalsCells
  49. Handy DE, Loscalzo J, Leopold JA. Systems analysis of oxidant stress in the vasculature. IUBMB Life. 2013 Nov; 65(11):911-20. PMID: 24265198.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  50. Leopold JA. Prohealing endothelial progenitor cell capture stents: do the cells captured explain the clinical outcomes? Circ Cardiovasc Interv. 2013 Oct 01; 6(5):494-5. PMID: 24129931.
    Citations: 1     Fields:    Translation:HumansCells
  51. Leopold JA. Cellular and molecular mechanisms of arterial stiffness associated with obesity. Hypertension. 2013 Dec; 62(6):1003-4. PMID: 24060893.
    Citations: 7     Fields:    Translation:Animals
  52. Kao DD, Oldebeken SR, Rai A, Lubos E, Leopold JA, Loscalzo J, Handy DE. Tumor necrosis factor-a-mediated suppression of dual-specificity phosphatase 4: crosstalk between NF?B and MAPK regulates endothelial cell survival. Mol Cell Biochem. 2013 Oct; 382(1-2):153-62. PMID: 23812841.
    Citations: 6     Fields:    Translation:HumansCells
  53. Hadri L, Kratlian RG, Benard L, Maron BA, Dorfmüller P, Ladage D, Guignabert C, Ishikawa K, Aguero J, Ibanez B, Turnbull IC, Kohlbrenner E, Liang L, Zsebo K, Humbert M, Hulot JS, Kawase Y, Hajjar RJ, Leopold JA. Therapeutic efficacy of AAV1.SERCA2a in monocrotaline-induced pulmonary arterial hypertension. Circulation. 2013 Jul 30; 128(5):512-23. PMID: 23804254.
    Citations: 24     Fields:    Translation:HumansAnimalsCells
  54. Maron BA, Waxman AB, Opotowsky AR, Gillies H, Blair C, Aghamohammadzadeh R, Loscalzo J, Leopold JA. Effectiveness of spironolactone plus ambrisentan for treatment of pulmonary arterial hypertension (from the [ARIES] study 1 and 2 trials). Am J Cardiol. 2013 Sep 01; 112(5):720-5. PMID: 23751938.
    Citations: 15     Fields:    Translation:HumansCTClinical Trials
  55. Leopold JA. Vascular calcification: an age-old problem of old age. Circulation. 2013 Jun 18; 127(24):2380-2. PMID: 23690467.
    Citations:    
  56. Balderman JA, Lee HY, Mahoney CE, Handy DE, White K, Annis S, Lebeche D, Hajjar RJ, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 decreases microRNA-30b and microRNA-30c to promote vascular smooth muscle cell calcification. J Am Heart Assoc. 2012 Dec; 1(6):e003905. PMID: 23316327.
    Citations: 35     Fields:    Translation:HumansCells
  57. Hecker PA, Leopold JA, Gupte SA, Recchia FA, Stanley WC. Impact of glucose-6-phosphate dehydrogenase deficiency on the pathophysiology of cardiovascular disease. Am J Physiol Heart Circ Physiol. 2013 Feb 15; 304(4):H491-500. PMID: 23241320.
    Citations: 20     Fields:    Translation:HumansAnimals
  58. Hecker PA, Lionetti V, Ribeiro RF, Rastogi S, Brown BH, O'Connell KA, Cox JW, Shekar KC, Gamble DM, Sabbah HN, Leopold JA, Gupte SA, Recchia FA, Stanley WC. Glucose 6-phosphate dehydrogenase deficiency increases redox stress and moderately accelerates the development of heart failure. Circ Heart Fail. 2013 Jan; 6(1):118-26. PMID: 23170010.
    Citations: 20     Fields:    Translation:AnimalsCells
  59. Zhang Z, Yang Z, Zhu B, Hu J, Liew CW, Zhang Y, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Increasing glucose 6-phosphate dehydrogenase activity restores redox balance in vascular endothelial cells exposed to high glucose. PLoS One. 2012; 7(11):e49128. PMID: 23185302.
    Citations: 11     Fields:    Translation:HumansAnimalsCells
  60. Maron BA, Opotowsky AR, Landzberg MJ, Loscalzo J, Waxman AB, Leopold JA. Plasma aldosterone levels are elevated in patients with pulmonary arterial hypertension in the absence of left ventricular heart failure: a pilot study. Eur J Heart Fail. 2013 Mar; 15(3):277-83. PMID: 23111998.
    Citations: 20     Fields:    Translation:Humans
  61. Leopold JA. Cellular mechanisms of aortic valve calcification. Circ Cardiovasc Interv. 2012 Aug 01; 5(4):605-14. PMID: 22896576.
    Citations: 32     Fields:    Translation:HumansCells
  62. Maron BA, Zhang YY, White K, Chan SY, Handy DE, Mahoney CE, Loscalzo J, Leopold JA. Aldosterone inactivates the endothelin-B receptor via a cysteinyl thiol redox switch to decrease pulmonary endothelial nitric oxide levels and modulate pulmonary arterial hypertension. Circulation. 2012 Aug 21; 126(8):963-74. PMID: 22787113.
    Citations: 41     Fields:    Translation:HumansAnimalsCells
  63. Leopold JA. Aldosterone, mineralocorticoid receptor activation, and cardiovascular remodeling. Circulation. 2011 Nov 01; 124(18):e466-8. PMID: 22042931.
    Citations: 6     Fields:    Translation:Humans
  64. Liberman M, Johnson RC, Handy DE, Loscalzo J, Leopold JA. Bone morphogenetic protein-2 activates NADPH oxidase to increase endoplasmic reticulum stress and human coronary artery smooth muscle cell calcification. Biochem Biophys Res Commun. 2011 Sep 30; 413(3):436-41. PMID: 21907184.
    Citations: 25     Fields:    Translation:HumansCells
  65. Lubos E, Kelly NJ, Oldebeken SR, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 deficiency augments proinflammatory cytokine-induced redox signaling and human endothelial cell activation. J Biol Chem. 2011 Oct 14; 286(41):35407-17. PMID: 21852236.
    Citations: 14     Fields:    Translation:HumansCells
  66. Dentin R, Tomas-Cobos L, Foufelle F, Leopold J, Girard J, Postic C, Ferré P. Glucose 6-phosphate, rather than xylulose 5-phosphate, is required for the activation of ChREBP in response to glucose in the liver. J Hepatol. 2012 Jan; 56(1):199-209. PMID: 21835137.
    Citations: 27     Fields:    Translation:HumansCells
  67. Campbell P, Leopold JA, Selwyn AP, Sisto D. Equalization of right- and left-sided intracardiac pressures: is it constriction? Circ Heart Fail. 2011 May; 4(3):369-73; discussion 374-7. PMID: 21586737.
    Citations:    Fields:    Translation:Humans
  68. Jin RC, Mahoney CE, Coleman Anderson L, Ottaviano F, Croce K, Leopold JA, Zhang YY, Tang SS, Handy DE, Loscalzo J. Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. Circulation. 2011 May 10; 123(18):1963-73. PMID: 21518981.
    Citations: 24     Fields:    Translation:AnimalsCells
  69. Leopold JA. Viral-derived Serp-1 as an adjunctive therapy for percutaneous coronary intervention: another not ready for prime time player? Circ Cardiovasc Interv. 2010 Dec; 3(6):528-30. PMID: 21156927.
    Citations:    Fields:    Translation:Humans
  70. Michas G, Liberman M, Becker KC, Handy DE, Loscalzo J, Leopold JA. Reciprocal regulation of 11ß-hydroxysteroid dehydrogenase 1 and glucocorticoid receptor expression by dexamethasone inhibits human coronary artery smooth muscle cell proliferation in vitro. Mol Cell Biochem. 2011 Jan; 346(1-2):69-79. PMID: 20922465.
    Citations:    Fields:    Translation:HumansAnimalsCells
  71. Leopold JA. Redox Pioneer: Professor Joseph Loscalzo. Antioxid Redox Signal. 2010 Oct 01; 13(7):1125-32. PMID: 20443733.
    Citations: 1     Fields:    Translation:HumansCells
  72. Hadri L, Bobe R, Kawase Y, Ladage D, Ishikawa K, Atassi F, Lebeche D, Kranias EG, Leopold JA, Lompré AM, Lipskaia L, Hajjar RJ. SERCA2a gene transfer enhances eNOS expression and activity in endothelial cells. Mol Ther. 2010 Jul; 18(7):1284-92. PMID: 20461063.
    Citations: 33     Fields:    Translation:HumansAnimalsCells
  73. Lubos E, Mahoney CE, Leopold JA, Zhang YY, Loscalzo J, Handy DE. Glutathione peroxidase-1 modulates lipopolysaccharide-induced adhesion molecule expression in endothelial cells by altering CD14 expression. FASEB J. 2010 Jul; 24(7):2525-32. PMID: 20219985.
    Citations: 10     Fields:    Translation:HumansCells
  74. Maron BA, Leopold JA. Aldosterone receptor antagonists: effective but often forgotten. Circulation. 2010 Feb 23; 121(7):934-9. PMID: 20177008.
    Citations: 17     Fields:    Translation:Humans
  75. Zhang Z, Liew CW, Handy DE, Zhang Y, Leopold JA, Hu J, Guo L, Kulkarni RN, Loscalzo J, Stanton RC. High glucose inhibits glucose-6-phosphate dehydrogenase, leading to increased oxidative stress and beta-cell apoptosis. FASEB J. 2010 May; 24(5):1497-505. PMID: 20032314.
    Citations: 36     Fields:    Translation:HumansAnimalsCells
  76. Leopold JA. Rapid aldosterone signaling and vascular reactivity: relax or don't do it. J Cardiovasc Pharmacol. 2009 Dec; 54(6):465-7. PMID: 19858736.
    Citations: 4     Fields:    Translation:HumansAnimalsCells
  77. Xu Y, Zhang Z, Hu J, Stillman IE, Leopold JA, Handy DE, Loscalzo J, Stanton RC. Glucose-6-phosphate dehydrogenase-deficient mice have increased renal oxidative stress and increased albuminuria. FASEB J. 2010 Feb; 24(2):609-16. PMID: 19805580.
    Citations: 20     Fields:    Translation:AnimalsCells
  78. Leopold JA, Loscalzo J. Oxidative risk for atherothrombotic cardiovascular disease. Free Radic Biol Med. 2009 Dec 15; 47(12):1673-706. PMID: 19751821.
    Citations: 48     Fields:    Translation:HumansCells
  79. Qin X, Hu W, Song W, Blair P, Wu G, Hu X, Song Y, Bauer S, Feelisch M, Leopold JA, Loscalzo J, Halperin JA. Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol. 2009 Apr; 84(4):221-7. PMID: 19229985.
    Citations: 9     Fields:    Translation:AnimalsCells
  80. Handy DE, Lubos E, Yang Y, Galbraith JD, Kelly N, Zhang YY, Leopold JA, Loscalzo J. Glutathione peroxidase-1 regulates mitochondrial function to modulate redox-dependent cellular responses. J Biol Chem. 2009 May 01; 284(18):11913-21. PMID: 19254950.
    Citations: 41     Fields:    Translation:HumansCells
  81. Maron BA, Zhang YY, Handy DE, Beuve A, Tang SS, Loscalzo J, Leopold JA. Aldosterone increases oxidant stress to impair guanylyl cyclase activity by cysteinyl thiol oxidation in vascular smooth muscle cells. J Biol Chem. 2009 Mar 20; 284(12):7665-72. PMID: 19141618.
    Citations: 34     Fields:    Translation:AnimalsCells
  82. Maron BA, Leopold JA. Mineralocorticoid receptor antagonists and endothelial function. Curr Opin Investig Drugs. 2008 Sep; 9(9):963-9. PMID: 18729003.
    Citations: 4     Fields:    Translation:HumansAnimals
  83. Leopold JA. Does thrombolytic therapy facilitate or foil primary PCI? N Engl J Med. 2008 May 22; 358(21):2277-9. PMID: 18499572.
    Citations: 2     Fields:    Translation:Humans
  84. Leopold JA, Loscalzo J. Oxidative mechanisms and atherothrombotic cardiovascular disease. Drug Discov Today Ther Strateg. 2008 Mar; 5(1):5-13. PMID: 21048889.
    Citations: 6     
  85. Munir K, Coulter S, Growdon JH, MacDonald A, Skerrett PJ, Leopold JA. How to solve three puzzles. Newsweek. 2008 Jan 21; 151(3):64, 66. PMID: 18314825.
    Citations:    Fields:    Translation:Humans
  86. Rajasekaran NS, Connell P, Christians ES, Yan LJ, Taylor RP, Orosz A, Zhang XQ, Stevenson TJ, Peshock RM, Leopold JA, Barry WH, Loscalzo J, Odelberg SJ, Benjamin IJ. Human alpha B-crystallin mutation causes oxido-reductive stress and protein aggregation cardiomyopathy in mice. Cell. 2007 Aug 10; 130(3):427-39. PMID: 17693254.
    Citations: 139     Fields:    Translation:HumansAnimalsCells
  87. Leopold JA, Dam A, Maron BA, Scribner AW, Liao R, Handy DE, Stanton RC, Pitt B, Loscalzo J. Aldosterone impairs vascular reactivity by decreasing glucose-6-phosphate dehydrogenase activity. Nat Med. 2007 Feb; 13(2):189-97. PMID: 17273168.
    Citations: 100     Fields:    Translation:HumansCells
  88. Seaver MR, Leopold JA, Gabeau GV, David M, Freund K, Clark W, Bord CL, Duvernoy CS, Galorowicz L, Willis MJ. The Heart Truth Professional Education Program Interactive Case Based Modules. 2007.
  89. Leopold, J.A. Cellules progenitrices endotheliales: implications cliniques et therapeutiques. Actualites Nephrologiques Jean Hamburger Eds. P. Lesavre, T. Drueke, C. Legendre, P. Niadet. 2007; 1-16.
  90. Leopold, JA. Glucose-6-phosphate dehydrogenase. 2007.
  91. Johnson RC, Leopold JA, Loscalzo J. Vascular calcification: pathobiological mechanisms and clinical implications. Circ Res. 2006 Nov 10; 99(10):1044-59. PMID: 17095733.
    Citations: 175     Fields:    Translation:HumansAnimals
  92. Leopold JA. Small-molecule glycoprotein IIb/IIIa antagonists and bleeding risk in women: too much of a good thing? Circulation. 2006 Sep 26; 114(13):1344-6. PMID: 17000918.
    Citations:    Fields:    Translation:Humans
  93. Hajjar RJ, Leopold JA. Xanthine oxidase inhibition and heart failure: novel therapeutic strategy for ventricular dysfunction? Circ Res. 2006 Feb 03; 98(2):169-71. PMID: 16456108.
    Citations: 7     Fields:    Translation:Animals
  94. Matsui R, Xu S, Maitland KA, Mastroianni R, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6-phosphate dehydrogenase deficiency decreases vascular superoxide and atherosclerotic lesions in apolipoprotein E(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Apr; 26(4):910-6. PMID: 16439706.
    Citations: 16     Fields:    Translation:AnimalsCells
  95. Galasso G, Schiekofer S, Sato K, Shibata R, Handy DE, Ouchi N, Leopold JA, Loscalzo J, Walsh K. Impaired angiogenesis in glutathione peroxidase-1-deficient mice is associated with endothelial progenitor cell dysfunction. Circ Res. 2006 Feb 03; 98(2):254-61. PMID: 16373599.
    Citations: 46     Fields:    Translation:AnimalsCells
  96. Pitt B, Leopold JA. A role for mineralocorticoid receptor blockade in the prevention of apoptosis. J Mol Cell Cardiol. 2005 Sep; 39(3):415-7. PMID: 15978610.
    Citations: 2     Fields:    Translation:Animals
  97. Matsui R, Xu S, Maitland KA, Hayes A, Leopold JA, Handy DE, Loscalzo J, Cohen RA. Glucose-6 phosphate dehydrogenase deficiency decreases the vascular response to angiotensin II. Circulation. 2005 Jul 12; 112(2):257-63. PMID: 15998684.
    Citations: 21     Fields:    Translation:AnimalsCells
  98. Leopold JA, Loscalzo J. Oxidative enzymopathies and vascular disease. Arterioscler Thromb Vasc Biol. 2005 Jul; 25(7):1332-40. PMID: 15790928.
    Citations: 36     Fields:    Translation:HumansAnimals
  99. Leopold JA, Antman EM. Dual antiplatelet therapy for coronary stenting: a clear path for a research agenda. Circulation. 2005 Mar 08; 111(9):1097-9. PMID: 15753225.
    Citations: 3     Fields:    
  100. Loscalzo J, Voetsch B, Liao R, Leopold J. Genetic determinants of vascular oxidant stress and endothelial dysfunction. Congest Heart Fail. 2005 Mar-Apr; 11(2):73-9. PMID: 15860972.
    Citations:    Fields:    Translation:Humans
  101. Loscalzo J, Leopold JA. Method and Composition for the Modulation of Angiogenesis. 2005.
  102. Leopold, JA and Loscalzo, J. . Rational contemporary molecular and cell-based therapies. In Loscalzo J, editor. Molecular Mechanisms of Atherosclerosis. 2005; 261-82.
  103. Jain M, Cui L, Brenner DA, Wang B, Handy DE, Leopold JA, Loscalzo J, Apstein CS, Liao R. Increased myocardial dysfunction after ischemia-reperfusion in mice lacking glucose-6-phosphate dehydrogenase. Circulation. 2004 Feb 24; 109(7):898-903. PMID: 14757696.
    Citations: 30     Fields:    Translation:AnimalsCells
  104. Walford GA, Moussignac RL, Scribner AW, Loscalzo J, Leopold JA. Hypoxia potentiates nitric oxide-mediated apoptosis in endothelial cells via peroxynitrite-induced activation of mitochondria-dependent and -independent pathways. J Biol Chem. 2004 Feb 06; 279(6):4425-32. PMID: 14597620.
    Citations: 25     Fields:    Translation:AnimalsCells
  105. Leopold JA, Loscalzo J. Organic nitrate tolerance and endothelial dysfunction: role of folate therapy. Minerva Cardioangiol. 2003 Aug; 51(4):349-59. PMID: 12900717.
    Citations: 1     Fields:    Translation:HumansAnimals
  106. Jain M, Brenner DA, Cui L, Lim CC, Wang B, Pimentel DR, Koh S, Sawyer DB, Leopold JA, Handy DE, Loscalzo J, Apstein CS, Liao R. Glucose-6-phosphate dehydrogenase modulates cytosolic redox status and contractile phenotype in adult cardiomyocytes. Circ Res. 2003 Jul 25; 93(2):e9-16. PMID: 12829617.
    Citations: 37     Fields:    Translation:AnimalsCells
  107. Leopold JA, Walker J, Scribner AW, Voetsch B, Zhang YY, Loscalzo AJ, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase modulates vascular endothelial growth factor-mediated angiogenesis. J Biol Chem. 2003 Aug 22; 278(34):32100-6. PMID: 12777375.
    Citations: 31     Fields:    Translation:AnimalsCells
  108. Jacobs AK, Leopold JA, Bates E, Mendes LA, Sleeper LA, White H, Davidoff R, Boland J, Modur S, Forman R, Hochman JS. Cardiogenic shock caused by right ventricular infarction: a report from the SHOCK registry. J Am Coll Cardiol. 2003 Apr 16; 41(8):1273-9. PMID: 12706920.
    Citations: 23     Fields:    Translation:Humans
  109. Leopold JA, Zhang YY, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase overexpression decreases endothelial cell oxidant stress and increases bioavailable nitric oxide. Arterioscler Thromb Vasc Biol. 2003 Mar 01; 23(3):411-7. PMID: 12615686.
    Citations: 41     Fields:    Translation:AnimalsCells
  110. Russo G, Leopold JA, Loscalzo J. Vasoactive substances: nitric oxide and endothelial dysfunction in atherosclerosis. Vascul Pharmacol. 2002 May; 38(5):259-69. PMID: 12487030.
    Citations: 17     Fields:    Translation:HumansAnimals
  111. Ruberg FL, Leopold JA, Loscalzo J. Atherothrombosis: plaque instability and thrombogenesis. Prog Cardiovasc Dis. 2002 Mar-Apr; 44(5):381-94. PMID: 12024336.
    Citations: 7     Fields:    Translation:Humans
  112. Leopold JA, Jacobs AK. Angiography and Angioplasty. In Douglas PS, editor. Cardiovascular Health and Disease in Women. 2002; 357-71.
  113. Leopold JA, Jacobs AK. Women and acute coronary syndromes. In Cannon CP, editor. Management of Acute Coronary Syndromes. 2002; 224-246.
  114. Leopold JA, Cap A, Scribner AW, Stanton RC, Loscalzo J. Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability. FASEB J. 2001 Aug; 15(10):1771-3. PMID: 11481225.
    Citations: 26     Fields:    Translation:Animals
  115. Leopold JA, Jacobs AK. Catheter-based revascularization strategies for acute coronary syndromes in women. Rev Cardiovasc Med. 2001; 2(4):181-9. PMID: 12439367.
    Citations:    Fields:    Translation:Humans
  116. Forgione MA, Leopold JA, Loscalzo J. Roles of endothelial dysfunction in coronary artery disease. Curr Opin Cardiol. 2000 Nov; 15(6):409-15. PMID: 11198623.
    Citations: 6     Fields:    Translation:HumansCells
  117. Leopold JA, Loscalzo J. Cyclic strain modulates resistance to oxidant stress by increasing G6PDH expression in smooth muscle cells. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2477-85. PMID: 11045985.
    Citations: 8     Fields:    Translation:AnimalsCells
  118. Eberhardt RT, Forgione MA, Cap A, Leopold JA, Rudd MA, Trolliet M, Heydrick S, Stark R, Klings ES, Moldovan NI, Yaghoubi M, Goldschmidt-Clermont PJ, Farber HW, Cohen R, Loscalzo J. Endothelial dysfunction in a murine model of mild hyperhomocyst(e)inemia. J Clin Invest. 2000 Aug; 106(4):483-91. PMID: 10953023.
    Citations: 78     Fields:    Translation:HumansAnimals
  119. Leopold JA, Loscalzo J. Clinical importance of understanding vascular biology. Cardiol Rev. 2000 Mar-Apr; 8(2):115-23. PMID: 11174883.
    Citations: 2     Fields:    Translation:Humans
  120. Leopold JA. Loscalzo J. S-nitrosothiols. In Loscalzo J, Vita J, editors. Nitric Oxide in the Cardiovascular System. 2000; 15:411-30..
  121. leopold JA, Loscalzo J. Platelets and fibrinolysis. In Berndt, M, editor. Platelets, Thrombosis and the Vessel Wall. 2000; 21-40.
  122. Leopold JA, Loscalzo J. Clinical importance of understanding vascular biology. Card. in Rev. 2000; 8:115-23..
  123. Leopold JA, Jacobs A. Treatment of closure and threatened closure. In Ellis SG, Holmes Jr, DR, editors. Strategic Approaches in Coronary Intervention. 2000; 489-500..
  124. Maytin M, Leopold J, Loscalzo J. Oxidant stress in the vasculature. Curr Atheroscler Rep. 1999 Sep; 1(2):156-64. PMID: 11122705.
    Citations: 20     Fields:    Translation:HumansAnimals
  125. Leopold JA, Loscalzo J. Vascular Smooth Muscle Cell Biology. In Rabbani LE, editor. Applications of Antisense Therapies to Restenosis. 1999; 45-70.
  126. Upchurch GR, Leopold JA, Welch GN, Loscalzo J. Nitric Oxide Alters Human Microvascular Endothelial Cell Response to Cyclic Strain. J Cardiovasc Pharmacol Ther. 1998 Apr; 3(2):135-142. PMID: 10684491.
    Citations: 4     Fields:    
  127. Leopold JA, Keaney JF, Jr, Loscalzo J. . Pharmacology of Thrombolytic Agents. In Loscalzo J, Schafer AI, editors. Thrombosis and Hemorrhage. 1998; 1215-58..
  128. Leopold JA, Loscalzo J. New developments in nitrosovasodilator therapy. Vasc Med. 1997; 2(3):190-202. PMID: 9546968.
    Citations: 1     Fields:    Translation:Humans
  129. Leopold JA, Loscalzo J. . Platelet Activation By Fibrinolytic Agents: A Potential Mechanism For Resistance to Thrombolysis and Reocclusion After Successful Thrombolysis. Cor Art Dis. 1996; 6:923-9..
  130. Leopold JA, Loscalzo J. Platelet activation by fibrinolytic agents: a potential mechanism for resistance to thrombolysis and reocclusion after successful thrombolysis. Coron Artery Dis. 1995 Dec; 6(12):923-9. PMID: 8723013.
    Citations:    Fields:    Translation:HumansAnimals
  131. Ganz P, Ludmer P, Leopold J, Hollenberg N, Shook TL, Wayne RL, Mudge GL, Alexander RW, Selwyn A. . Endothelial Dysfunction in vivo. Studies in Animals and in Patients with Coronary Atherosclerosis. In: Vanhoutte PM, editor. Vasodilation: Vascular Smooth Muscle, Peptides, Autonomic Nerves, and Endothelium. 1988; 543-549.
  132. Ganz P, Davies PF, Leopold JA, Gimbrone MA, Alexander RW. Short- and long-term interactions of endothelium and vascular smooth muscle in coculture: effects on cyclic GMP production. Proc Natl Acad Sci U S A. 1986 May; 83(10):3552-6. PMID: 3010304.
    Citations: 12     Fields:    Translation:AnimalsCells
  133. Ganz P, Sandrock AW, Landis SC, Leopold J, Gimbrone MA, Alexander RW. Vasoactive intestinal peptide: vasodilatation and cyclic AMP generation. Am J Physiol. 1986 May; 250(5 Pt 2):H755-60. PMID: 3010741.
    Citations: 5     Fields:    Translation:AnimalsCells
  134. Ganz P, Sandrock AW, Landis SC, Leopold J, Gimbrone M, Alexander RW. Vasoactive Intestinal Peptide; Vasodilation and Cyclic AMP Generation. Am J of Physiol. 1986; 250:H755-60.
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Funded by the NIH/NCATS Clinical and Translational Science Award (CTSA) program, grant number UL1TR001102, and through institutional support from Harvard University, Harvard Medical School, Harvard T.H. Chan School of Public Health, Beth Israel Deaconess Medical Center, Boston Children's Hospital, Brigham and Women's Hospital, Massachusetts General Hospital and the Dana Farber Cancer Institute.